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MT-ATP8 Gene

protein-coding   GIFtS: 38
GCID: GCMTP008368

Mitochondrially Encoded ATP Synthase 8

(Previous name: ATP synthase 8)
(Previous symbol: MTATP8)
  See MT-ATP8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrially Encoded ATP Synthase 81     ATP Synthase F0 Subunit 82
MTATP81 2 3     A6L3
ATP82 3     ATPASE83
ATP Synthase 81     F-ATPase Subunit 83
ATPase82     

External Ids:    HGNC: 74151   Entrez Gene: 45092   Ensembl: ENSG000002282537   OMIM: 5160705   UniProtKB: P039283   

Export aliases for MT-ATP8 gene to outside databases

Previous GC identifer: GC00U921583


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT-ATP8 Gene:
MT-ATP8 (mitochondrially encoded ATP synthase 8) is a protein-coding gene. Diseases associated with MT-ATP8 include periodic paralysis with later-onset distal motor neuropathy, and mitochondrial complex v deficiency, mitochondrial 2.

UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
presence of a proton gradient across the membrane which is generated by electron transport complexes of the
respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a
peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit
located with subunit a in the membrane (By similarity)

Gene Wiki entry for MT-ATP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MT-ATP8
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT-ATP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-ATP8


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP008368:       (about GC identifiers)

Start:
8,366 bp from pter      End:
8,572 bp from pter
Size:
207 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928 (See protein sequence)
Recommended Name: ATP synthase protein 8  
Size: 68 amino acids; 7992 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6,
MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity)
Secondary accessions: Q34771

Explore the universe of human proteins at neXtProt for MT-ATP8: NX_P03928

Explore proteomics data for MT-ATP8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys40
  • Modification sites at PhosphoSitePlus

  • See MT-ATP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000355265  
    Reactome Protein details: P03928

    MT-ATP8 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for MT-ATP8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FATP: Mitochondrial respiratory chain complex / Complex V
    F1ATP: ATPases / F-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: 8
    F-type ATPase

    1 InterPro protein domain:
     IPR001421 ATPase_F0-cplx_su8_mt_metazoan

    Graphical View of Domain Structure for InterPro Entry P03928

    ProtoNet protein and cluster: P03928

    1 Blocks protein domain: IPB001421 Mitochondrial ATPase

    UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928
    Similarity: Belongs to the ATPase protein 8 family


    Find genes that share domains with MT-ATP8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATP8_HUMAN, P03928
    Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the
    presence of a proton gradient across the membrane which is generated by electron transport complexes of the
    respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous
    catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a
    peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary
    mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit
    located with subunit a in the membrane (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015078hydrogen ion transmembrane transporter activity ----
    GO:0016887ATPase activity ----
    GO:0022857transmembrane transporter activity ----
         
    Find genes that share ontologies with MT-ATP8           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for mt-Atp8):
     behavior/neurological 

    Find genes that share phenotypes with MT-ATP8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT-ATP8
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATP8_HUMAN, P03928: Mitochondrion membrane; Single-pass membrane protein

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000276mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ----
    GO:0005743mitochondrial inner membrane ----
    GO:0005753mitochondrial proton-transporting ATP synthase complex ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with MT-ATP8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MT-ATP8 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Formation of ATP by chemiosmotic coupling0.00
    Oxidative phosphorylation0.64
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3purine nucleotide salvage
    purine nucleotide salvage0.78
    adenosine ribonucleotides de novo biosynthesis0.51
    purine nucleotides de novo biosynthesis0.78
    4Alzheimer's disease
    Alzheimer's disease0.44


    Find genes that share SuperPaths with MT-ATP8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for MT-ATP8
        purine nucleotides de novo biosynthesis
    Electron Transport Chain
    purine nucleotide salvage
    adenosine ribonucleotides de novo biosynthesis

    1 Reactome Pathway for MT-ATP8
        Formation of ATP by chemiosmotic coupling


    5 Kegg Pathways  (Kegg details for MT-ATP8):
        Oxidative phosphorylation
    Metabolic pathways
    Alzheimer's disease
    Parkinson's disease
    Huntington's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-ATP8
    Interactions:

        Search GeneGlobe Interaction Network for MT-ATP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MT-ATP8 (P039283 ENSP000003552654) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAPGEF2Q9Y4G83, ENSP000002644314I2D: score=2 STRING: ENSP00000264431
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    PACSIN1Q9BY113, ENSP000002444584I2D: score=3 STRING: ENSP00000244458
    GRB2P629933, ENSP000003390074I2D: score=3 STRING: ENSP00000339007
    WNK1Q9H4A33, ENSP000003130594I2D: score=3 STRING: ENSP00000313059
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process ----
    GO:0015986ATP synthesis coupled proton transport ----
    GO:0022904respiratory electron transport chain ----
    GO:0042776mitochondrial ATP synthesis coupled proton transport ----
    GO:0044237cellular metabolic process ----

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT-ATP8 (ATP8)

    4 HMDB Compounds for MT-ATP8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for MT-ATP8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadh 53.9 5 19066432 (1), 16861209 (1), 15855057 (1), 17619138 (1) (see all 5)
    rrna 46.5 3 17464880 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361851
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MT-ATP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MT-ATP8 Expression
    About this image

    MT-ATP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT-ATP8 Protein Expression
        Custom PCR Arrays for MT-ATP8
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MT-ATP8 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia mt-Atp85 mitochondrially encoded ATP synthase 8   --   MT 7766 


    ENSEMBL Gene Tree for MT-ATP8 (if available)
    TreeFam Gene Tree for MT-ATP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MT-ATP8 gene
    3 SIMAP similar genes for MT-ATP8 using alignment to 1 protein entry:     ATP8_HUMAN:
    ATPase 8    atp8    ATP8

    Find genes that share paralogs with MT-ATP8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for MT-ATP8    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr MT posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0695274
    Mitochondrial complex V deficiency, mitochondrial 2 (MC5DM2)4--see VAR_0695272 W R mis40--------
    VAR_0085654
    ----see VAR_0085652 M T mis40--------
    VAR_0085644
    ----see VAR_0085642 F S mis40--------
    VAR_0085634
    ----see VAR_0085632 L P mis40--------

    HapMap Linkage Disequilibrium report for MT-ATP8 (8366 - 8572 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MT-ATP8: --
    Human Gene Mutation Database (HGMD): MT-ATP8
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MT-ATP8
    DNA2.0 Custom Variant and Variant Library Synthesis for MT-ATP8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 516070    OMIM disorders: --

    UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928
  • Mitochondrial complex V deficiency, mitochondrial 2 (MC5DM2) [MIM:516070]: A mitochondrial disorder with
    heterogeneous clinical manifestations including neuropathy, ataxia, hypertrophic cardiomyopathy. Hypertrophic
    cardiomyopathy can present with negligible to extreme hypertrophy, minimal to extensive fibrosis and myocyte
    disarray, absent to severe left ventricular outflow tract obstruction, and distinct septal contours/morphologies
    with extremely varying clinical course. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 4 diseases for MT-ATP8:    
    About MalaCards
    periodic paralysis with later-onset distal motor neuropathy    mitochondrial complex v deficiency, mitochondrial 2    kearns-sayre syndrome    mitochondrial complex v deficiency


    Find genes that share disorders with MT-ATP8           About GenesLikeMe

    Genetic Association Database (GAD): MT-ATP8

    Export disorders for MT-ATP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT-ATP8 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with MT-ATP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PubMed id 17619138)1, 4, 9 Ahari S.E....Bahar M.A. (Cell. Mol. Neurobiol. 2007)
    2. Polymorphisms in the coding region of mtDNA and effects on clinical outcome of unrelated bone marrow transplantation. (PubMed id 11607774)1, 4 Ishikawa Y....Juji T. (Bone Marrow Transplant. 2001)
    3. Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (Nature 1981)
    4. Infantile cardiomyopathy caused by a mutation in the overlapping region of mitochondrial ATPase 6 and 8 genes. (PubMed id 19188198)2, 9 Ware S.M....Wong L.J. (J. Med. Genet. 2009)
    5. Mitochondrial tRNALeu/Lys and ATPase 6/8 gene variations in spinocerebellar ataxias. (PubMed id 19066432)1, 9 Safaei S....Shariati P. (Neurodegener Dis 2009)
    6. Mitochondrial ATP 6 and 8 polymorphisms in irritable bowel syndrome with diarrhea. (PubMed id 23840124)1 Wang W.F....Li H.H. (World J. Gastroenterol. 2013)
    7. Episodic weakness due to mitochondrial DNA MT-ATP6/8 mutations. (PubMed id 24153443)1 Aure K.... Lombes A. (Neurology 2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4509 HGNC: 7415 Ensembl:ENSG00000228253 euGenes: HUgn4509 ECgene: MT-ATP8 Kegg: 4509
    H-InvDB: MT-ATP8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MT-ATP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT-ATP8 gene:
    Search GeneIP for patents involving MT-ATP8

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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