MT-ATP8 Gene
protein-coding GIFtS: 35
GCID: GCMTP008368
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mitochondrially encoded ATP synthase 8(Previous name: ATP synthase 8 )
(Previous symbol: MTATP8)
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Aliases
for MT-ATP8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrially Encoded ATP Synthase 81 | | ATPase82 | | ATP81 2 3 | | ATP Synthase F0 Subunit 82 | | MTATP81 2 3 | | ATPASE83 | | A6L1 3 | | F-ATPase Subunit 83 | | ATP Synthase 81 | | |
Export aliases for MT-ATP8 gene to outside databasesPrevious GC identifer: GC00U921583 |
Summaries
for MT-ATP8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in thepresence of a proton gradient across the membrane which is generated by electron transport complexes of therespiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalyticcore and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalksubunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in themembrane (By similarity)
Gene Wiki entry for MT-ATP8
|
Genomic Views
for MT-ATP8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MT-ATP8
Other transcription factors
Search SABiosciences Chromatin IP Primers for MT-ATP8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-ATP8 |
Genomic Location:
Chromosome:MT
Ensembl cytogenetic band: MT HGNC chromosome: mitochondriaGeneLoc information about chromosome MT GeneLoc Exon Structure GeneLoc location for GCMTP008368: view genomic region
(about GC identifiers)
Start:
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8,366 bp from pter |
End:
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8,572 bp from pter |
Size:
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207 bases |
Orientation:
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plus strand |
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Proteins
for MT-ATP8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928 (See
protein sequence)Recommended Name: ATP synthase protein 8 Size: 68 amino acids; 7992 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8,ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity)
Subcellular location: Mitochondrion membrane; Single-pass membrane protein
Secondary accessions: Q34771Explore the universe of human proteins at neXtProt for MT-ATP8: NX_P03928
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P03928
MT-ATP8 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000355265 Reactome Protein details: P03928
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) |
NAS | -- | | GO:0005739 | mitochondrion |
-- | -- | | GO:0005743 | mitochondrial inner membrane |
TAS | -- | | GO:0005753 | mitochondrial proton-transporting ATP synthase complex |
IDA | 12110673 | | GO:0016021 | integral to membrane |
IEA | -- |
MT-ATP8 for ontologies About GeneDecksing
MT-ATP8 Antibody Products:
Assay Products for MT-ATP8: |
Protein
Domains /
Families
for MT-ATP8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MT-ATP8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P03928ProtoNet protein and cluster: P03928 1 Blocks protein family: IPB001421 Mitochondrial ATPase
UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928Similarity: Belongs to the ATPase protein 8 family |
Function
for MT-ATP8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in thepresence of a proton gradient across the membrane which is generated by electron transport complexes of therespiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalyticcore and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalksubunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in themembrane (By similarity)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MT-ATP8 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for mt-Atp8):
MT-ATP8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MT-ATP8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | | | 3 | Formation of ATP by chemiosmotic coupling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for MT-ATP8
4 
Reactome Pathways for MT-ATP8
5 
Kegg Pathways (Kegg details for MT-ATP8):
MT-ATP8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT-ATP8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/58 Interacting proteins for MT-ATP8 (P039283 ENSP000003552654) via UniProtKB, MINT, STRING, and/or I2D (see all 58)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006200 | ATP catabolic process |
IDA | 12110673 | | GO:0015986 | ATP synthesis coupled proton transport |
NAS | -- | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0042776 | mitochondrial ATP synthesis coupled proton transport |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
MT-ATP8 for ontologies About GeneDecksing
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Drugs & Compounds
for MT-ATP8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MT-ATP8 for compounds About GeneDecksing
 Browse Tocris compounds for MT-ATP8
4 HMDB Compounds for MT-ATP8 About this table
2 Novoseek chemical compound relationships for MT-ATP8 gene About this table
Search CenterWatch for drugs/clinical trials and news about MT-ATP8 / ATP8
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Transcripts
for MT-ATP8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000361851
GeneLoc Exon Structure
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Expression
for MT-ATP8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MT-ATP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MT-ATP8 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for MT-ATP8
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MT-ATP8 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-ATP8 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-ATP8 |
Orthologs
for MT-ATP8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for MT-ATP8 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
mt-Atp85 |
mitochondrially encoded ATP synthase 8 |
-- |
|
MT 7766 |
ENSEMBL Gene Tree for MT-ATP8 (if available)
TreeFam Gene Tree for MT-ATP8 (if available) |
Paralogs
for MT-ATP8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MT-ATP8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): MT-ATP8
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MT-ATP8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MT-ATP8 for disorders About GeneDecksing
OMIM gene information: 516070
OMIM disorders: --
10  diseases for MT-ATP8: About MalaCardscomplex v spinocerebellar ataxia epithelial ovarian cancer multiple sclerosis
ovarian cancer huntington's disease parkinson's disease ataxia
cardiomyopathy acne
Genetic Association Database (GAD): MT-ATP8
Export disorders for MT-ATP8 gene to outside databases
|
Publications
for MT-ATP8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MT-ATP8 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with MT-ATP8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Polymorphisms in the coding region of mtDNA and effects on clinical outcome of unrelated bone marrow transplantation. (PubMed id 11607774)1, 4 Ishikawa Y....Juji T. (2001)
- Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (1981)
- Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PubMed id 17619138)1, 9 Ahari S.E....Bahar M.A. (2007)
- Mitochondrial tRNALeu/Lys and ATPase 6/8 gene variations in spinocerebellar ataxias. (PubMed id 19066432)1, 9 Safaei S....Shariati P. (2009)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- MtSNPscore: a combined evidence approach for assessin g cumulative impact of mitochondrial variations in disease. (PubMed id 19758471)1 Bhardwaj A....Tiwari S. (2009)
- Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians. (PubMed id 14760490)2 Coble M.D.... Parsons T.J. (2004)
- Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines. (PubMed id 12840039)2 Ingman M. and Gyllensten U. (2003)
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External Searches for MT-ATP8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MT-ATP8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MT-ATP8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MT-ATP8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MT-ATP8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MT-ATP8 gene:
Search GeneIP for patents involving MT-ATP8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MT-ATP8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT-ATP8 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT-ATP8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-ATP8 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT-ATP8 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-ATP8 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-ATP8 |
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 |  |  |  | |
| | | | Search Tocris compounds for MT-ATP8 |
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 | | | MT-ATP8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MT-ATP8 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-ATP8 |
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