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MSTO1 Gene

protein-coding   GIFtS: 51
GCID: GC01P155580

Misato 1, Mitochondrial Distribution And Morphology Regulator

(Previous name: misato homolog 1 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Misato 1, Mitochondrial Distribution And Morphology Regulator1 2
Misato Homolog 1 (Drosophila)1
MST2
Misato Homolog 12
Protein Misato Homolog 12

External Ids:    HGNC: 296781   Entrez Gene: 551542   Ensembl: ENSG000001254597   UniProtKB: Q9BUK63   

Export aliases for MSTO1 gene to outside databases

Previous GC identifers: GC01P152396 GC01P153846 GC01P126941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MSTO1 Gene:
MSTO1 (misato 1, mitochondrial distribution and morphology regulator) is a protein-coding gene. Diseases associated with MSTO1 include macular retinal edema, and sick sinus syndrome.

UniProtKB/Swiss-Prot: MSTO1_HUMAN, Q9BUK6
Function: Involved in the regulation of mitochondrial distribution and morphology

Gene Wiki entry for MSTO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSTO1 gene promoter:
         HOXA9B   HOXA9   E2F-3a   E2F-4   E2F-5   E2F-2   E2F-1   E2F   Meis-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSTO1 promoter sequence
   Search Chromatin IP Primers for MSTO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSTO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

MSTO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSTO1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155580:  view genomic region     (about GC identifiers)

Start:
155,579,979 bp from pter      End:
155,718,153 bp from pter
Size:
138,175 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MSTO1_HUMAN, Q9BUK6 (See protein sequence)
Recommended Name: Protein misato homolog 1  
Size: 570 amino acids; 61835 Da
Sequence caution: Sequence=AAM12424.1; Type=Frameshift; Positions=419;
Secondary accessions: Q53GR8 Q5CZ69 Q5T717 Q68CT6 Q7LBZ8 Q7Z3M7 Q7Z558 Q8TE05 Q9NQX2 Q9NVU4
Alternative splicing: 7 isoforms:  Q9BUK6-1   Q9BUK6-2   Q9BUK6-3   Q9BUK6-4   Q9BUK6-5   Q9BUK6-6   Q9BUK6-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MSTO1: NX_Q9BUK6

Explore proteomics data for MSTO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys529
  • Modification sites at PhosphoSitePlus

  • See MSTO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243461.1  NP_001243462.1  NP_060586.2  

    ENSEMBL proteins: 
     ENSP00000476353   ENSP00000245564   ENSP00000357325   ENSP00000476693   ENSP00000440200  
     ENSP00000444133  

    MSTO1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MSTO1
    OriGene Custom MassSpec
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    Novus Biologicals MSTO1 Protein
    Novus Biologicals MSTO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MSTO1

    MSTO1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MSTO1
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    ThermoFisher Antibodies for MSTO1
    LSBio Antibodies in human, mouse, rat for MSTO1

    MSTO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MSTO1
    Cloud-Clone Corp. CLIAs for MSTO1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003008 Tubulin_FtsZ_GTPase
     IPR019605 Misato_II_tubulin-like

    Graphical View of Domain Structure for InterPro Entry Q9BUK6

    ProtoNet protein and cluster: Q9BUK6

    UniProtKB/Swiss-Prot: MSTO1_HUMAN, Q9BUK6
    Similarity: Belongs to the misato family


    MSTO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSTO1_HUMAN, Q9BUK6
    Function: Involved in the regulation of mitochondrial distribution and morphology

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    MSTO1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MSTO1:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSTO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSTO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSTO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSTO1

    miRNA
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    miRTarBase miRNAs that target MSTO1:
    hsa-mir-10b-5p (MIRT047477), hsa-mir-615-3p (MIRT039736), hsa-mir-484 (MIRT042347)

    Block miRNA regulation of human, mouse, rat MSTO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSTO1 (see all 18):
    hsa-miR-1287 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-3921 hsa-miR-3692 hsa-miR-4267 hsa-miR-3605-5p hsa-miR-3908
    SwitchGear 3'UTR luciferase reporter plasmidMSTO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MSTO1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MSTO1 (NM_018116)
    Sino Biological Human cDNA Clone for MSTO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSTO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSTO1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MSTO1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MSTO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSTO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MSTO1_HUMAN, Q9BUK6: Mitochondrion outer membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus2
    peroxisome2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005741mitochondrial outer membrane IDA17349998

    MSTO1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MSTO1: 
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MSTO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for MSTO1 (Q9BUK63 ENSP000002455644) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2DNLQ8IWF73I2D: score=1 
    DLDENSP000002054024STRING: ENSP00000205402
    GSRENSP000002211304STRING: ENSP00000221130
    TXNRD1ENSP000004120454STRING: ENSP00000412045
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007005mitochondrion organization IMP17349998
    GO:0048311mitochondrion distribution IMP17349998

    MSTO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSTO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MSTO1 gene (3 alternative transcripts): 
    NM_001256532.1  NM_001256533.1  NM_018116.3  

    Unigene Cluster for MSTO1:

    Misato homolog 1 (Drosophila)
    Hs.656547  [show with all ESTs]
    Unigene Representative Sequence: BC070067
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000488901 ENST00000460199 ENST00000490743 ENST00000471209 ENST00000245564(uc001fkw.3 uc001fkx.3 uc001fky.3 uc001fld.4 uc009wqs.3 uc010pgf.2)
    ENST00000368341 ENST00000494995(uc001flb.3) ENST00000482284 ENST00000490642
    ENST00000491308 ENST00000483832 ENST00000465137 ENST00000473327 ENST00000483734(uc001flc.3 uc001fla.3)
    ENST00000478756 ENST00000475253 ENST00000466815 ENST00000462250
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MSTO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSTO1 (see all 18):
    hsa-miR-1287 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-3921 hsa-miR-3692 hsa-miR-4267 hsa-miR-3605-5p hsa-miR-3908
    SwitchGear 3'UTR luciferase reporter plasmidMSTO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MSTO1
    Predesigned siRNA for gene silencing in human, mouse, rat MSTO1
    Clone
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    OriGene clones in human, mouse for MSTO1 (see all 7)
    OriGene ORF clones in mouse, rat for MSTO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSTO1 (NM_018116)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSTO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSTO1
    Primer
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    OriGene qPCR primer pairs and template standards for MSTO1
    OriGene qSTAR qPCR primer pairs in human, mouse for MSTO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSTO1
      QuantiTect SYBR Green Assays in human, mouse, rat MSTO1
      QuantiFast Probe-based Assays in human, mouse, rat MSTO1

    Additional mRNA sequence: 

    AF272833.1 AK001366.1 AK056128.1 AK092950.1 AK222863.1 AK290610.1 AK295146.1 AK297140.1 
    AK309573.1 AY334564.1 BC002535.2 BC070067.1 BX537684.1 CR749791.1 CR936872.1 NR_046292.1 
    NR_046293.1 NR_046294.1 NR_046295.1 

    Selected DOTS entries (see all 32):

    DT.91775886  DT.100809869  DT.97766349  DT.100810628  DT.97862556  DT.113587  DT.121381154  DT.100785758 
    DT.95311424  DT.101984997  DT.95323269  DT.121381418  DT.95148787  DT.91775862  DT.121381218  DT.121381362 
    DT.113586  DT.91775859  DT.100810629  DT.121381452  DT.100785763  DT.100810632  DT.121381249  DT.121381251 

    Selected AceView cDNA sequences (see all 142):

    BC070067 BI831680 BF591219 NM_018116 AI682642 BQ227621 BI831165 BF508805 
    AW512427 BM787147 BM808779 AX747823 AL578904 CK430827 AK001366 BQ675405 
    AI422143 BX492616 CR749791 CA487495 AK056128 AI434718 AA337242 BQ880348 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MSTO1 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ·
    SP1:                                            -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP2:                                                                                -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP3:                                            -     -     -           -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP4:                                            -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                            -     -     -                             -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 14c ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23
    SP1:  -     -     -     -     -           -                                                                                 
    SP2:  -     -     -     -     -           -                                                                                 
    SP3:  -     -           -     -                                                                                             
    SP4:  -                 -     -                                                                                             
    SP5:  -     -     -     -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for MSTO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSTO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACATTTA
    MSTO1 Expression
    About this image

    MSTO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSTO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656547

    UniProtKB/Swiss-Prot: MSTO1_HUMAN, Q9BUK6
    Tissue specificity: Present in all cell lines tested (at protein level). Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including MSTO1: 
              Mitochondria in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MSTO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSTO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MSTO1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msto11 , 5 misato homolog 1 (Drosophila)1, 5 83.03(n)1
    79.68(a)1
      3 (39.01 cM)5
    2295241  NM_144898.21  NP_659147.21 
     889051075 
    chicken
    (Gallus gallus)
    Aves MSTO11 misato homolog 1 (Drosophila) 59.22(n)
    56.11(a)
      425066  XM_422860.4  XP_422860.2 
    lizard
    (Anolis carolinensis)
    Reptilia MSTO16
    misato 1, mitochondrial distribution and morpholog...
    52(a)
    1 ↔ 1
    GL343519.1(366887-379711)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA986429.12   -- 75.77(n)    CA986429.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi40a102 wufi40a10 73.46(n)   334306  BC044406.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mst1 misato 42.98(n)
    32.1(a)
      33119  NM_078711.4  NP_523435.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G371901 AT4G37190 40.57(n)
    30.86(a)
      829873  NM_119882.2  NP_195436.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02409001 Os03g0240900 43.51(n)
    31.91(a)
      4332207  NM_001056047.1  NP_001049512.1 


    ENSEMBL Gene Tree for MSTO1 (if available)
    TreeFam Gene Tree for MSTO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSTO1 gene

    MSTO1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MSTO1
    PGOHUM00000251137


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSTO1 (see all 175)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352029811,2
    C--155578042(+) CTCTAA/GTTCCT 7 -- us2k12Minor allele frequency- G:0.09NA 122
    rs341244161,2
    C,F--155578049(+) TCCTGC/GGCTGA 7 -- us2k110Minor allele frequency- G:0.47NA WA CSA EA 370
    rs762682201,2
    F--155578138(+) AGAGAG/AGATAG 7 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1880573711,2
    --155578159(+) AGTCTA/CACTAC 7 -- us2k10--------
    rs1485300021,2
    --155578164(+) CACTAC/TATTGT 7 -- us2k10--------
    rs120775581,2
    C,F--155578262(+) ctctgC/Tgccca 7 -- us2k12Minor allele frequency- T:0.17WA 120
    rs1807590901,2
    --155578331(+) TGTTGC/TCCAAG 7 -- us2k10--------
    rs1874602761,2
    --155578367(+) CTCACC/TGCAAG 7 -- us2k10--------
    rs1918232561,2
    --155578453(+) CACGCC/TCGGCT 7 -- us2k10--------
    rs1454776141,2
    --155578457(+) CCCGGC/TTAATT 7 -- us2k10--------

    HapMap Linkage Disequilibrium report for MSTO1 (155579979 - 155718153 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MSTO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436522CNV Deletion17901297
    esv2718418CNV Deletion23290073
    nsv3043CNV Loss18451855
    esv33869CNV Loss17666407
    nsv428246CNV Gain18775914
    nsv482134CNV Gain20164927

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSTO1
    DNA2.0 Custom Variant and Variant Library Synthesis for MSTO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for MSTO1:    About MalaCards
    macular retinal edema    sick sinus syndrome    sinusitis    retinitis
    inflammatory bowel disease    malaria


    MSTO1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MSTO1

    Export disorders for MSTO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSTO1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with MSTO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Misato regulates mitochondrial distribution and morphology. (PubMed id 17349998)1, 2, 3 Kimura M. and Okano Y. (Exp. Cell Res. 2007)
    2. An anthropoid-specific segmental duplication on human chromosome 1q22. (PubMed id 16545939)1, 3 Kuryshev V.Y....Wiemann S. (Genomics 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55154 HGNC: 29678 AceView: FLJ10504 Ensembl:ENSG00000125459 euGenes: HUgn55154
    ECgene: MSTO1 H-InvDB: MSTO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSTO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSTO1 gene:
    Search GeneIP for patents involving MSTO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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