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Aliases for MSTO1 Gene

Aliases for MSTO1 Gene

  • Misato 1, Mitochondrial Distribution And Morphology Regulator 2 3 5
  • Misato Homolog 1 (Drosophila) 2
  • Protein Misato Homolog 1 3
  • Misato Homolog 1 3
  • LST005 3
  • MST 3

External Ids for MSTO1 Gene

Previous GeneCards Identifiers for MSTO1 Gene

  • GC01P152396
  • GC01P153846
  • GC01P155580
  • GC01P126941

Summaries for MSTO1 Gene

GeneCards Summary for MSTO1 Gene

MSTO1 (Misato 1, Mitochondrial Distribution And Morphology Regulator) is a Protein Coding gene. GO annotations related to this gene include GTPase activity.

UniProtKB/Swiss-Prot for MSTO1 Gene

  • Involved in the regulation of mitochondrial distribution and morphology.

Gene Wiki entry for MSTO1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSTO1 Gene

Genomics for MSTO1 Gene

Regulatory Elements for MSTO1 Gene

Enhancers for MSTO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156095 1.6 VISTA FANTOM5 Ensembl ENCODE 1.6 +487.3 487262 3.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 ELK1 ZNF207 MEF2D RIT1 GON4L YY1AP1 MSTO1 LMNA GC01M156123
GH01F155608 1.1 ENCODE 0.8 -0.4 -413 1.9 HDGF ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GBA MSTO1 LOC284620
GH01F155598 1.2 FANTOM5 Ensembl ENCODE 0.4 -10.7 -10677 1.8 ATF1 PTRF RAD21 ZNF263 CEBPB MEF2D CREB3 ZNF585B IKZF1 ZBTB33 PYGO2 ASH1L LOC101928120 MIR555 ASH1L-AS1 RUSC1 RUSC1-AS1 RNU6-1297P FDPS MSTO2P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MSTO1 on UCSC Golden Path with GeneCards custom track

Promoters for MSTO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000545584 31 1600 HDGF ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2

Genomic Location for MSTO1 Gene

Chromosome:
1
Start:
155,610,170 bp from pter
End:
155,614,967 bp from pter
Size:
4,798 bases
Orientation:
Plus strand

Genomic View for MSTO1 Gene

Genes around MSTO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSTO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSTO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSTO1 Gene

Proteins for MSTO1 Gene

  • Protein details for MSTO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUK6-MSTO1_HUMAN
    Recommended name:
    Protein misato homolog 1
    Protein Accession:
    Q9BUK6
    Secondary Accessions:
    • Q53GR8
    • Q5CZ69
    • Q5T717
    • Q68CT6
    • Q7LBZ8
    • Q7Z3M7
    • Q7Z558
    • Q8TE05
    • Q9NQX2
    • Q9NVU4

    Protein attributes for MSTO1 Gene

    Size:
    570 amino acids
    Molecular mass:
    61835 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM12424.1; Type=Frameshift; Positions=419; Evidence={ECO:0000305};

    Alternative splice isoforms for MSTO1 Gene

neXtProt entry for MSTO1 Gene

Post-translational modifications for MSTO1 Gene

  • Ubiquitination at Lys 529
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MSTO1 Gene

Domains & Families for MSTO1 Gene

Protein Domains for MSTO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUK6

UniProtKB/Swiss-Prot:

MSTO1_HUMAN :
  • Belongs to the misato family.
Family:
  • Belongs to the misato family.
genes like me logo Genes that share domains with MSTO1: view

No data available for Gene Families for MSTO1 Gene

Function for MSTO1 Gene

Molecular function for MSTO1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of mitochondrial distribution and morphology.

Gene Ontology (GO) - Molecular Function for MSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
genes like me logo Genes that share ontologies with MSTO1: view
genes like me logo Genes that share phenotypes with MSTO1: view

Animal Model Products

miRNA for MSTO1 Gene

miRTarBase miRNAs that target MSTO1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSTO1 Gene

Localization for MSTO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSTO1 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSTO1 Gene COMPARTMENTS Subcellular localization image for MSTO1 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for MSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA,IDA 17349998
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MSTO1: view

Pathways & Interactions for MSTO1 Gene

SuperPathways for MSTO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IMP 17349998
GO:0048311 mitochondrion distribution IMP 17349998
genes like me logo Genes that share ontologies with MSTO1: view

No data available for Pathways by source and SIGNOR curated interactions for MSTO1 Gene

Transcripts for MSTO1 Gene

Unigene Clusters for MSTO1 Gene

Misato homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSTO1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ·
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - -
SP8:
SP9: - -
SP10: - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12:
SP13: - - - - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18: - - - - - - - - - - - - - - - - -

ExUns: 14c ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - - - - - - - - -
SP8:
SP9: -
SP10: -
SP11: - -
SP12:
SP13: - - - - - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for MSTO1 Gene

GeneLoc Exon Structure for
MSTO1
ECgene alternative splicing isoforms for
MSTO1

Expression for MSTO1 Gene

mRNA expression in normal human tissues for MSTO1 Gene

Protein differential expression in normal tissues from HIPED for MSTO1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.7), Testis (14.5), and Heart (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSTO1 Gene



Protein tissue co-expression partners for MSTO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MSTO1 Gene:

MSTO1

SOURCE GeneReport for Unigene cluster for MSTO1 Gene:

Hs.656547

mRNA Expression by UniProt/SwissProt for MSTO1 Gene:

Q9BUK6-MSTO1_HUMAN
Tissue specificity: Present in all cell lines tested (at protein level). Widely expressed.
genes like me logo Genes that share expression patterns with MSTO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MSTO1 Gene

Orthologs for MSTO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSTO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSTO1 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia MSTO1 34 35
  • 87.66 (n)
dog
(Canis familiaris)
Mammalia MSTO1 34 35
  • 84.62 (n)
mouse
(Mus musculus)
Mammalia Msto1 34 16 35
  • 83.03 (n)
rat
(Rattus norvegicus)
Mammalia Msto1 34
  • 82.52 (n)
oppossum
(Monodelphis domestica)
Mammalia MSTO1 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSTO1 34 35
  • 59.22 (n)
lizard
(Anolis carolinensis)
Reptilia MSTO1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msto1 34
  • 56.42 (n)
zebrafish
(Danio rerio)
Actinopterygii msto1 34 35
  • 53.37 (n)
wufi40a10 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002778 34
  • 44.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta mst 34 35
  • 42.98 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DML1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G37190 34
  • 40.57 (n)
rice
(Oryza sativa)
Liliopsida Os03g0240900 34
  • 43.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for MSTO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSTO1 Gene

ENSEMBL:
Gene Tree for MSTO1 (if available)
TreeFam:
Gene Tree for MSTO1 (if available)

Paralogs for MSTO1 Gene

Pseudogenes.org Pseudogenes for MSTO1 Gene

genes like me logo Genes that share paralogs with MSTO1: view

No data available for Paralogs for MSTO1 Gene

Variants for MSTO1 Gene

Sequence variations from dbSNP and Humsavar for MSTO1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111594745 -- 155,612,689(+) TGTGA(C/T)GTGGC intron-variant, upstream-variant-2KB
rs112258960 -- 155,613,505(+) ATGCA(C/T)GTACC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs112490079 -- 155,608,266(+) TGAAG(C/T)GATCC upstream-variant-2KB
rs112689533 -- 155,610,368(+) GCCCT(A/T)CGGGA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs112742067 -- 155,615,188(+) CTACT(A/G)AAAAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MSTO1 Gene

Variant ID Type Subtype PubMed ID
esv2718418 CNV deletion 23290073
esv33869 CNV loss 17666407
esv3890671 CNV gain 25118596
nsv3043 CNV deletion 18451855
nsv428246 CNV gain 18775914
nsv436522 CNV deletion 17901297
nsv482134 CNV gain 20164927
nsv547965 CNV gain 21841781
nsv946419 CNV duplication 23825009

Variation tolerance for MSTO1 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSTO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSTO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSTO1 Gene

Disorders for MSTO1 Gene

Relevant External Links for MSTO1

Genetic Association Database (GAD)
MSTO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSTO1

No disorders were found for MSTO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSTO1 Gene

Publications for MSTO1 Gene

  1. Human Misato regulates mitochondrial distribution and morphology. (PMID: 17349998) Kimura M. … Okano Y. (Exp. Cell Res. 2007) 2 3 4 64
  2. An anthropoid-specific segmental duplication on human chromosome 1q22. (PMID: 16545939) Kuryshev V.Y. … Wiemann S. (Genomics 2006) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MSTO1 Gene

Sources for MSTO1 Gene

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