MSTN Gene

Aliases
for MSTN gene

Previous GC identifers: GC02M190629 GC02M182780

Summaries
for MSTN gene

Genomic Views
for MSTN gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_005403.17  

SwitchGear Promoter luciferase reporter plasmid: MSTN promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSTN

MSTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M190920:  view genomic region     (about GC identifiers)

Proteins
for MSTN gene

Explore the universe of human proteins at neXtProt for MSTN: NX_O14793

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for MSTN (GDF-8/Myostatin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MSTN OriGene Protein Over-expression Lysate: MSTN OriGene Custom Protein Services for MSTN
	GenScript Custom Purified and Recombinant Proteins Services for MSTN
	Novus Biologicals MSTN Proteins Novus Biologicals MSTN Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MSTN
	Uscn Proteins for MSTN

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MSTN
	R&D Systems Antibodies for MSTN (GDF-8/Myostatin)
	Browse OriGene Antibodies OriGene Custom Antibody Services for MSTN
	GenScript Custom Superior Antibodies Services for MSTN
	Novus Biologicals MSTN Antibodies
	Abcam antibodies for MSTN
	Uscn Antibodies for MSTN
	ThermoFisher Antibodies for MSTN

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MSTN (GDF-8/Myostatin)
	GenScript Custom Assay Services for MSTN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MSTN

Protein Domains /
Families
for MSTN gene

ProtoNet protein and cluster: O14793

Function
for MSTN gene

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 7 alleles) (MGI details for Mstn)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MSTN

miRNA Products:		OriGene 3'-UTR Clone: MSTN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSTN
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MSTN (see all 11):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-29a hsa-miR-29c hsa-miR-508-3p hsa-miR-518a-5p hsa-miR-3662
		SwitchGear 3'UTR luciferase reporter plasmid: MSTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSTN (see all 7) OriGene shRNA RFP: MSTN OriGene siRNA: MSTN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSTN
		Sirion Biotech Custom design and validation of potent shRNA sequences against MSTN

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MSTN
			Sirion Biotech Customized adenovirus for overexpression of MSTN  Sirion Biotech Customized adenovirus for potent knockdown of MSTN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSTN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSTN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MSTN (NM_005259)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSTN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MSTN
		Search LifeMap BioReagents cell lines for MSTN
		Sirion Biotech Customized stable knockdown cell line services for MSTN  Sirion Biotech Customized inducible knockdown cell line services for MSTN Sirion Biotech Customized stable overexpressing cell line services for MSTN Sirion Biotech Customized inducible overexpressing cell line services for MSTN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSTN

Pathways & Interactions
for MSTN gene

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

Drugs & Compounds
for MSTN gene

Transcripts
for MSTN gene

Expression
for MSTN gene

MSTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGCTGTAT

About this image

MSTN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

10/60 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 60)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LimbForelimb Dorsal MusclesMononuclear Myocytes			Skeletal Muscle
	LimbForelimb Ventral MusclesMononuclear Myocytes			Skeletal Muscle
	LimbHindlimb Dorsal MuscleMononuclear Myocytes			Skeletal Muscle
	LimbHindlimb Ventral MuscleMononuclear Myocytes			Skeletal Muscle
	Skeletal MuscleThoracic Epaxial MyotomeMononuclear Myocytes			Skeletal Muscle
	SomiteCervical Epaxial MyotomeMononuclear Myocytes			Skeletal Muscle
	SomiteCervical Hypaxial MyotomeMononuclear Myocytes			Skeletal Muscle
	SomiteCervical Primary Epaxial MyotomeMononuclear Myocytes			Skeletal Muscle
	SomiteCervical Primary Hypaxial MyotomeMononuclear Myocytes			Skeletal Muscle
	SomiteLumbar Epaxial MyotomeMononuclear Myocytes			Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSTN

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSTN

Orthologs
for MSTN gene

Paralogs
for MSTN gene

Paralogs for MSTN gene

TGFB3²  INHBC²  GDF11²  INHBE²  INHBA²  TGFB1²  INHBB²  TGFB2²  

2 SIMAP similar genes for MSTN using alignment to 1 protein entry:     GDF8_HUMAN:

GDF8    GDF11

MSTN for paralogs           About GeneDecksing

Genomic Variants
for MSTN gene

10/172 NCBI SNPs in MSTN are shown (see all 172)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs121051651,2	F,H	--	182780477(+)	ATACTG/CTTTCT	1	--	ut31		6		NS EA WA NA	644
rs31874151,2	C,F,H	--	182780788(-)	CTTATG/CGATTC	1	--	ut31 ese3		13		MN NS EA NA WA	1894
rs729093361,2	C	--	182781249(+)	AGTATG/ACTACA	1	--	ut31		2		NA	122
rs1145976061,2	C,F	--	182781417(+)	CCTATC/TGTATT	1	--	ut31		1		WA	118
rs38282681,2	H	--	182781463(+)	AATTAT/CAATAG	1	--	ut31		4		NS EA	418
rs168322851,2	C,F,H	--	182781498(+)	CATCCC/TTATTT	1	--	ut31		14		NA NS EA WA	1974
rs168239861,2	C,F,H	--	182781596(+)	CTGCAT/GTTTAC	1	--	ut31		14		NA NS EA WA CSA	1454
rs561248071,2	C	--	182781764(+)	TTCTAG/TCTCAA	1	--	ut31		1		WA	2
rs604908641,2	C,F	--	182781856(+)	GTTTAC/TATACT	1	--	ut31		3		WA CSA	122
rs168239881,2	H	--	182782008(+)	ACAGCG/CGTCTA	2	/R /G	mis1 ese3		7		NA NS EA	548

HapMap Linkage Disequilibrium report for MSTN (190920426 - 190927455 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MSTN: --
Human Gene Mutation Database (HGMD): MSTN

Locus Specific Mutation Databases (LSDB): MSTN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSTN

DNA2.0 Custom Variant and Variant Library Synthesis for MSTN

Disorders / Diseases
for MSTN gene

20/30 diseases for MSTN

10/23 Novoseek disease relationships for MSTN gene (see all 23)    About this table

Publications
for MSTN gene

PubMed articles for MSTN gene, integrated from 9 sources (see all 325): (articles sorted by number of sources associating them with MSTN)

Utopia: connect your pdf to the dynamic world of online information

1. Human adaptive evolution at myostatin (GDF8), a regulator of muscle growth. (PubMed id 17186467)^{1, 2, 9} Saunders M.A....Nachman M.W. (2006)
2. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. (PubMed id 9843994)^{1, 2, 9} Gonzalez-Cadavid N.F.... Bhasin S. (1998)
3. Regulation of myostatin in vivo by growth and differentiation factor- associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. (PubMed id 12595574)^{1, 2, 9} Hill J.J.... Wolfman N.M. (2003)
4. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. (PubMed id 10610713)^{1, 3, 9} Ferrell R.E....Hurley B.F. (1999)
5. Myostatin mutation associated with gross muscle hypertrophy in a child. (PubMed id 15215484)^{1, 2, 9} Schuelke M....Lee S.J. (2004)
6. A proposed nomenclature consensus for the myostatin g ene family. (PubMed id 17003236)^{1, 3} Rodgers B.D....Goetz F.W. (2007)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. (PubMed id 9288100)^{1, 3} Grobet L....Georges M. (1997)
9. Double muscling in cattle due to mutations in the myostatin gene. (PubMed id 9356471)^{1, 2} McPherron A.C. and Lee S.-J. (1997)
10. The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum. (PubMed id 12194980)^{1, 9} Hill J.J....Qiu Y. (2002)

External Searches for MSTN gene

Genome Databases showing MSTN gene

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Specialized Databases showing MSTN gene

Products
for MSTN gene