Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MSTN Gene

protein-coding   GIFtS: 61
GCID: GC02M190920

Myostatin

(Previous name: growth differentiation factor 8)
(Previous symbol: GDF8)
  See MSTN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Myostatin3     GDF-82 3
myostatin1 2     MSLHP2 5
GDF81 2 3 5     Growth/Differentiation Factor 82
Growth Differentiation Factor 81 2     

External Ids:    HGNC: 42231   Entrez Gene: 26602   Ensembl: ENSG000001383797   OMIM: 6017885   UniProtKB: O147933   

Export aliases for MSTN gene to outside databases

Previous GC identifers: GC02M190629 GC02M182780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MSTN Gene:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta
superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved
to produce a mature protein containing seven conserved cysteine residues. The members of this family are
regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode
a secreted protein which negatively regulates skeletal muscle growth. (provided by RefSeq, Jul 2008)

GeneCards Summary for MSTN Gene:
MSTN (myostatin) is a protein-coding gene. Diseases associated with MSTN include myostatin-related muscle hypertrophy, and alcoholic cardiomyopathy. GO annotations related to this gene include cytokine activity and identical protein binding. An important paralog of this gene is GDF11.

UniProtKB/Swiss-Prot: GDF8_HUMAN, O14793
Function: Acts specifically as a negative regulator of skeletal muscle growth

Gene Wiki entry for MSTN (Myostatin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSTN gene promoter:
         LHX3b/Lhx3b   AP-4   Ik-3   Nkx6-1   FOXO1a   LHX3a/Lhx3a   TGIF   NF-kappaB1   MRF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSTN promoter sequence
   Search Chromatin IP Primers for MSTN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.2   Ensembl cytogenetic band:  2q32.2   HGNC cytogenetic band: 2q32.1

MSTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSTN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M190920:  view genomic region     (about GC identifiers)

Start:
190,920,423 bp from pter      End:
190,927,455 bp from pter
Size:
7,033 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GDF8_HUMAN, O14793 (See protein sequence)
Recommended Name: Growth/differentiation factor 8 precursor  
Size: 375 amino acids; 42750 Da
Subunit: Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.
Interacts with FST3
Secondary accessions: A1C2J7 A1C2K0 Q6B0H2

Explore the universe of human proteins at neXtProt for MSTN: NX_O14793

Explore proteomics data for MSTN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71

  • See MSTN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005250.1  
    ENSEMBL proteins: 
     ENSP00000260950  

    MSTN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MSTN (GDF-8/Myostatin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MSTN
    OriGene Protein Over-expression Lysate for MSTN
    OriGene MassSpec for MSTN
    OriGene Custom Protein Services for MSTN
    GenScript Custom Purified and Recombinant Proteins Services for MSTN
    Novus Biologicals MSTN Proteins
    Novus Biologicals MSTN Lysate
    Sino Biological Recombinant Protein for MSTN
    Sino Biological Cell Lysate for MSTN
    ProSpec Recombinant Protein for MSTN
    Cloud-Clone Corp. Proteins for MSTN

     
    Search eBioscience for Proteins for MSTN 

    MSTN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MSTN
    R&D Systems Antibodies for MSTN (GDF-8/Myostatin)
    OriGene Antibodies for MSTN
    OriGene Custom Antibody Services for MSTN
    Novus Biologicals MSTN Antibodies
    Abcam antibodies for MSTN
    Cloud-Clone Corp. Antibodies for MSTN
    ThermoFisher Antibodies for MSTN
    LSBio Antibodies in human, mouse, rat for MSTN

    MSTN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MSTN
    R&D Systems ELISAs for MSTN (GDF-8/Myostatin)
    GenScript Custom Assay Services for MSTN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MSTN
    Cloud-Clone Corp. CLIAs for MSTN
    Search eBioscience for ELISAs for MSTN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR015616 GDF_8
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry O14793

    ProtoNet protein and cluster: O14793

    2 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)


    UniProtKB/Swiss-Prot: GDF8_HUMAN, O14793
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with MSTN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDF8_HUMAN, O14793
    Function: Acts specifically as a negative regulator of skeletal muscle growth

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102contributes to receptor binding IPI14517293
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding IPI--
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with MSTN           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 9 alleles(MGI details for Mstn) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  growth/size/body  homeostasis/metabolism  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  no phenotypic analysis  renal/urinary system 

    Find genes that share phenotypes with MSTN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MSTN: Mstntm1.1Swel Mstntm1.1Mgs Mstntm1Sjl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSTN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSTN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSTN

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MSTN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSTN (see all 11):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-29a hsa-miR-29c hsa-miR-508-3p hsa-miR-518a-5p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidMSTN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MSTN
    Predesigned siRNA for gene silencing in human, mouse, rat MSTN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MSTN

    Clone
    Products:
         
    OriGene clones in human, mouse for MSTN (see all 6)
    OriGene ORF clones in mouse, rat for MSTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSTN (NM_005259)
    Sino Biological Human cDNA Clone for MSTN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSTN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MSTN
    Browse ESI BIO Cell Lines and PureStem Progenitors for MSTN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSTN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GDF8_HUMAN, O14793: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with MSTN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MSTN About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway
    2Hypertrophy Model
    Hypertrophy Model


    1 BioSystems Pathway for MSTN
        Hypertrophy Model

    1 Sino Biological Pathway for MSTN
        TGF-beta Signaling Pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including MSTN: 
              Growth Factors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MSTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for MSTN (O147931, 2, 3 ENSP000002609504) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR2BQ137051, 2, 3, ENSP000003403614EBI-8542977,EBI-1383577 MINT-8432603 MINT-8432640 MINT-8432783 MINT-8432617 I2D: score=2 STRING: ENSP00000340361
    WFIKKN1Q96NZ81, 2EBI-8542977,EBI-2363713 MINT-8432687 MINT-8432804 MINT-8432657 MINT-8432707
    MSTNO147931, 2EBI-8542977,EBI-8542977 MINT-8432817
    FSTL3O956333, ENSP000001661394I2D: score=2 STRING: ENSP00000166139
    SGTAO437653, ENSP000002215664I2D: score=2 STRING: ENSP00000221566
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007179transforming growth factor beta receptor signaling pathway IEA--
    GO:0007517muscle organ development TAS9843994
    GO:0009408response to heat IEA--
    GO:0009629response to gravity IEA--
    GO:0014732skeletal muscle atrophy IEA--

    Find genes that share ontologies with MSTN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSTN (GDF8)

    8 Novoseek inferred chemical compound relationships for MSTN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 24.5 28 18841527 (5), 11701429 (3), 17095559 (3), 19356623 (3) (see all 11)
    rapamycin 16.4 3 19533653 (1), 19071005 (1), 19357233 (1)
    glycerol 3-phosphate 13.2 5 11237745 (1), 16849634 (1)
    oxygen 2.06 2 18500383 (1), 15355854 (1)
    ribonucleic acid 0 1 16638502 (1)
    glucose 0 18 17711997 (5), 19295913 (2), 16464946 (2), 20103742 (1) (see all 6)
    glyceraldehyde 3-phosphate 0 1 12676749 (1)
    dexamethasone 0 1 11701425 (1)



    Find genes that share compounds with MSTN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MSTN gene: 
    NM_005259.2  

    Unigene Cluster for MSTN:

    Myostatin
    Hs.41565  [show with all ESTs]
    Unigene Representative Sequence: AF104922
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260950(uc002urp.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MSTN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSTN (see all 11):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-29a hsa-miR-29c hsa-miR-508-3p hsa-miR-518a-5p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidMSTN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MSTN
    Predesigned siRNA for gene silencing in human, mouse, rat MSTN
    Clone
    Products:
         
    OriGene clones in human, mouse for MSTN (see all 6)
    OriGene ORF clones in mouse, rat for MSTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSTN (NM_005259)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSTN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MSTN
    OriGene qSTAR qPCR primer pairs in human, mouse for MSTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSTN
      QuantiTect SYBR Green Assays in human, mouse, rat MSTN
      QuantiFast Probe-based Assays in human, mouse, rat MSTN

    Additional mRNA sequence: 

    AF019627.1 AF104922.1 AK291524.1 BC074757.2 

    1 DOTS entry:

    DT.211022 

    13 AceView cDNA sequences:

    AA476520 BC074757 BX093210 AF019627 N80248 AA476419 AA446796 AA432111 
    BE296886 NM_005259 AF104922 W07375 W24782 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MSTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCTGTAT
    MSTN Expression
    About this image


    MSTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 38 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Sacral Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hippocampus
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
    MSTN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSTN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.41565
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MSTN: 
              Growth Factors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MSTN
    OriGene qSTAR qPCR primer pairs in human, mouse for MSTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSTN
    QuantiTect SYBR Green Assays in human, mouse, rat MSTN
    QuantiFast Probe-based Assays in human, mouse, rat MSTN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MSTN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mstn1 , 5 myostatin1, 5 91.82(n)1
    96.27(a)1
      1 (26.99 cM)5
    177001  NM_010834.21  NP_034964.11 
     530616635 
    chicken
    (Gallus gallus)
    Aves MSTN1 myostatin 84.98(n)
    92(a)
      373964  NM_001001461.1  NP_001001461.1 
    lizard
    (Anolis carolinensis)
    Reptilia MSTN6
    myostatin
    89(a)
    1 ↔ 1
    2(134860432-134873766)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004964081 growth/differentiation factor 8-like 74.53(n)
    77.24(a)
      100496408  XM_002931522.2  XP_002931568.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mstnb1 myostatin b 65.94(n)
    69.67(a)
      798441  NM_131019.4  NP_571094.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta myo1 myoglianin 45.3(n)
    36.22(a)
      43811  NM_166786.2  NP_726604.1 


    ENSEMBL Gene Tree for MSTN (if available)
    TreeFam Gene Tree for MSTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MSTN gene
    GDF112  INHBE2  TGFB22  INHBB2  TGFB32  INHBC2  INHBA2  TGFB12  
    2 SIMAP similar genes for MSTN using alignment to 1 protein entry:     GDF8_HUMAN:
    GDF8    GDF11

    Find genes that share paralogs with MSTN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MSTN (see all 214)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820233271,2
    --190306345(+) AAAAAC/TCAAAC 1 -- ds50010--------
    rs1850475671,2
    --190306596(+) AAAATA/TAAAAA 1 -- ds50010--------
    rs1402304171,2
    --190306639(+) CTTTCA/GTATGT 1 -- ds50010--------
    rs1899395361,2
    --190306708(+) GCAGAA/CCTAAA 1 -- ds50010--------
    rs1813964711,2
    --190306761(+) AATAAA/TGTGAA 1 -- ds50010--------
    rs37917811,2
    C,F,H--190306768(+) TGAAAA/GTCAGA 1 -- ds500111Minor allele frequency- G:0.11EA NS NA 1522
    rs121051651,2
    F,H--190306852(+) ATACTG/CTTTCT 1 -- ut316Minor allele frequency- C:0.07NS EA WA NA 644
    rs1441677261,2
    C--190306916(+) TAACAA/GAATCC 1 -- ut310--------
    rs37917821,2
    C--190307034(+) GATAAT/CAGAGT 1 -- ut314Minor allele frequency- C:0.21EA NA WA 1548
    rs1864812381,2
    --190307148(+) TTATAC/TAGCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MSTN (190920423 - 190927455 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MSTN: --
    Human Gene Mutation Database (HGMD): MSTN
    Locus Specific Mutation Databases (LSDB): MSTN

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSTN
    DNA2.0 Custom Variant and Variant Library Synthesis for MSTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601788   
    OMIM disorders: 614160  
    UniProtKB/Swiss-Prot: GDF8_HUMAN, O14793
  • Muscle hypertrophy (MSLHP) [MIM:614160]: A condition characterized by increased muscle bulk and strength.
    Affected individuals are exceptionally strong. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 7 diseases for MSTN:    
    About MalaCards
    myostatin-related muscle hypertrophy    alcoholic cardiomyopathy    peyronie's disease    inclusion body myositis
    myotonia    myositis    duchenne muscular dystrophy

    2 diseases from the University of Copenhagen DISEASES database for MSTN:
    Myopathy     Neuropathy

    Find genes that share disorders with MSTN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MSTN gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lgmd1c 78.3 7 19108573 (3), 17039257 (2), 17432227 (1)
    muscular dystrophies 74.4 21 19108572 (3), 16231730 (2), 16638502 (2), 17432227 (2) (see all 15)
    hypertrophy 73.6 47 19383783 (4), 16883577 (2), 12717734 (1), 15215484 (1) (see all 35)
    atrophy disuse 67.1 2 19656243 (1), 17376604 (1)
    atrophy 66.3 50 18335407 (4), 16533345 (3), 17039257 (3), 15726494 (2) (see all 26)
    myopathy 60.7 9 19383783 (2), 16436040 (2), 18248537 (1), 16793037 (1) (see all 7)
    muscular dystrophy duchenne 60.6 5 17432227 (1), 20161803 (1), 18288893 (1), 15221330 (1) (see all 5)
    wasting syndrome 49.6 2 17432227 (1), 16246158 (1)
    neuromuscular diseases 46.6 2 19783146 (1), 17261282 (1)
    mitochondrial encephalomyopathies 28.5 3 16638502 (2), 16996410 (1)

    GeneTests: MSTN
    GeneReviews: MSTN
    Genetic Association Database (GAD): MSTN
    Human Genome Epidemiology (HuGE) Navigator: MSTN (17 documents)

    Export disorders for MSTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MSTN gene, integrated from 10 sources (see all 336):
    (articles sorted by number of sources associating them with MSTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human adaptive evolution at myostatin (GDF8), a regulator of muscle growth. (PubMed id 17186467)1, 2, 9 Saunders M.A....Nachman M.W. (Am. J. Hum. Genet. 2006)
    2. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. (PubMed id 9843994)1, 2, 9 Gonzalez-Cadavid N.F.... Bhasin S. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. Regulation of myostatin in vivo by growth and differentiation factor- associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. (PubMed id 12595574)1, 2, 9 Hill J.J.... Wolfman N.M. (Mol. Endocrinol. 2003)
    4. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. (PubMed id 10610713)1, 3, 9 Ferrell R.E....Hurley B.F. (Genomics 1999)
    5. Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity. (PubMed id 19346981)1, 4, 9 Kostek M.A....Pescatello L.S. (Med Sci Sports Exerc 2009)
    6. Does the polygenic profile determine the potential for becoming a world-class athlete? Insights from the sport of rowing. (PubMed id 19422651)1, 4, 9 Santiago C....Lucia A. (amp 2010)
    7. Myostatin mutation associated with gross muscle hypertrophy in a child. (PubMed id 15215484)1, 2, 9 Schuelke M.... Lee S.J. (N. Engl. J. Med. 2004)
    8. Polymorphisms in the IGF1 signalling pathway including the myostatin gene are associated with left ventricular mass in male athletes. (PubMed id 19136503)1, 4 Karlowatz R.J....Zang K.D. (Br J Sports Med 2011)
    9. World-class performance in lightweight rowing: is it genetically influenced? A comparison with cyclists, runners and non-athletes. (PubMed id 18801770)1, 4 Muniesa C.A....Lucia A. (Br J Sports Med 2010)
    10. Can we identify a power-oriented polygenic profile? (PubMed id 20044471)1, 4 Ruiz J.R....Lucia A. (J. Appl. Physiol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2660 HGNC: 4223 AceView: GDF8 Ensembl:ENSG00000138379 euGenes: HUgn2660
    ECgene: MSTN H-InvDB: MSTN

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MSTN Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/322347/
    Wikipedia http://en.wikipedia.org/wiki/Myostatin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MSTN gene:
    Search GeneIP for patents involving MSTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of MSTN
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for MSTN (GDF-8/Myostatin)   Browse Cell Culture Products  
     ELISAs for MSTN (GDF-8/Myostatin)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for MSTN (GDF-8/Myostatin)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MSTN   OriGene RNAi products in human, mouse, rat for MSTN  
     OriGene qPCR primer pairs and template standards for MSTN   OriGene Protein Over-expression Lysate for MSTN  
     OriGene MassSpec something-or-other for MSTN   OriGene clones in human, mouse for MSTN  
     OriGene qSTAR qPCR primer pairs in human, mouse for MSTN   OriGene Purified Protein for MSTN  
     OriGene ORF clones in mouse, rat for MSTN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MSTN   OriGene Custom Protein Services for MSTN  

     
     
     Block miRNA regulation of human, mouse, rat MSTN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MSTN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSTN Predesigned siRNA for gene silencing in human, mouse, rat MSTN
     QuantiFast Probe-based Assays in human, mouse, rat MSTN QuantiTect SYBR Green Assays in human, mouse, rat MSTN
     PCR Arrays including human, mouse, rat MSTN Search Chromatin IP Primers for MSTN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSTN  GeneGlobe Interaction Network for MSTN
     Regulatory tfbs in MSTN promoter
     GenScript Custom Purified and Recombinant Proteins Services for MSTN GenScript cDNA clones with any tag delivered in your preferred vector for MSTN
     GenScript Custom Assay Services for MSTN GenScript Custom overexpressing Cell Line Services for MSTN
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MSTN (GDF8)
     Proteins for MSTN
     Cell Lysates for MSTN
     cDNA Clones for MSTN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MSTN antibodies
     MSTN proteins
     MSTN lysates
     Antibodies for MSTN
     See all of Abcam's Antibodies, Kits and Proteins for MSTN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MSTN
     Proteins for MSTN
     Antibodies for MSTN
     ELISAs for MSTN
     CLIAs for MSTN



     Browse ESI BIO Cell Lines and PureStem Progenitors for MSTN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSTN
     SwitchGear 3'UTR luciferase reporter plasmids for MSTN
     SwitchGear Promoter luciferase reporter plasmids for MSTN
     ThermoFisher Antibodies for MSTN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSTN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSTN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSTN
     LSBio Antibodies in human, mouse, rat for MSTN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MSTN
      Search eBioscience for proteins for MSTN
      Search eBioscience for elisas for MSTN
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MSTN gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4