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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MST4 Gene

protein-coding   GIFtS: 55
GCID: GC0XP131158

Serine/Threonine Protein Kinase MST4


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mammalian STE20-Like Protein Kinase 42 3     Mammalian Sterile 20-Like 42
Serine/Threonine-Protein Kinase MASK2 3     Serine/Threonine Protein Kinase MST42
MASK2 3     Serine/Threonine-Protein Kinase MST42
Mst3 And SOK1-Related Kinase2 3     MST-43
STE20-Like Kinase MST42 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    Entrez Gene: 517652   Ensembl: ENSG000001346027   OMIM: 3005475   UniProtKB: Q9P2893   

Export aliases for MST4 gene to outside databases

Previous GC identifers: GC0XP125803 GC0XP128003 GC0XP129102 GC0XP129862 GC0XP130882 GC0XP120561


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MST4 Gene:
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like
kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain
that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated
by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the
apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the
full-length nature of some of these variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for MST4 Gene: 
MST4 is a protein-coding gene. Diseases associated with MST4 include cerebral cavernous malformations 3, and cavernous malformation, and among its related super-pathways are Apoptotic execution phase and Regulation of Apoptosis. GO annotations related to this gene include protein kinase activity and identical protein binding. An important paralog of this gene is STK24.

UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289
Function: Mediator of cell growth. Modulates apoptosis

Gene Wiki entry for MST4 (RP6-213H19.1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MST4 gene promoter:
         POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MST4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.2   Ensembl cytogenetic band:  Xq26.2   

MST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP131158:  view genomic region     (about GC identifiers)

Start:
131,157,245 bp from pter      End:
131,209,971 bp from pter
Size:
52,727 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase MST4  
Size: 416 amino acids; 46529 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer. Interacts with PDCD10 and GOLGA2. Interacts with CTTNBP2NL
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Note=Localizes to the Golgi apparatus
5 PDB 3D structures from and Proteopedia for MST4:
3GGF (3D)        4FZA (3D)        4FZD (3D)        4FZF (3D)        4GEH (3D)    
Secondary accessions: B2RAU2 Q3ZB77 Q8NC04 Q9BXC3 Q9BXC4
Alternative splicing: 3 isoforms:  Q9P289-1   Q9P289-2   Q9P289-3   

Explore the universe of human proteins at neXtProt for MST4: NX_Q9P289

Explore proteomics data for MST4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P289

  • 4/14 DME Specific Peptides for MST4 (Q9P289) (see all 14)
     LLKHKFI  GITAIEL  LDYLHSE  WMAPEVI 

    MST4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MST4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035917.1  NP_001035918.1  NP_057626.2  

    ENSEMBL proteins: 
     ENSP00000377867   ENSP00000418753   ENSP00000346755   ENSP00000377868   ENSP00000419702  
    Reactome Protein details: Q9P289
    Human Recombinant Protein Products for MST4: 
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    Novus Biologicals MST4 Lysates
    Sino Biological Recombinant Protein for MST4
    Sino Biological Cell Lysate for MST4 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005829cytosol TAS--

    MST4 for ontologies           About GeneDecksing



    MST4 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine-protein kinase MST4 
    YSK subfamily

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9P289

    ProtoNet protein and cluster: Q9P289

    UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    MST4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MST4_HUMAN, Q9P289
    Function: Mediator of cell growth. Modulates apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly
    as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA11641781
    GO:0004672protein kinase activity IDA11641781
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI17360971
         
    MST4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MST4:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Decreased telomerase activity 

         1 MGI phenotypic allele for 2610018G03Rik (no phenotypes)

    MST4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MST4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MST4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MST4 
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MST4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.73
    Apoptotic execution phase0.73
    2CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.39
    3LKB1 signaling events
    LKB1 signaling events
    4Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MST4
        Cytoskeletal Signaling

    1 BioSystems Pathway for MST4
        LKB1 signaling events


    3        Reactome Pathways for MST4
        Apoptotic execution phase
    Apoptotic cleavage of cellular proteins
    Apoptosis



    MST4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MST4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for MST4 (Q9P2891, 2, 3 ENSP000003778674) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39Q9Y3762, 3, ENSP000002584184MINT-8186588 MINT-8186788 MINT-8186577 MINT-8186607 MINT-8186820 MINT-8186804 I2D: score=1 STRING: ENSP00000258418
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-618239,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    ENSG00000215641P143733I2D: score=1 
    ENSG00000229006P143733I2D: score=1 
    ENSG00000234495P143733I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11641781
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0042981regulation of apoptotic process IDA11741893

    MST4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MST4

    3 HMDB Compounds for MST4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for MST4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about MST4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MST4 gene (3 alternative transcripts): 
    NM_001042452.1  NM_001042453.1  NM_016542.3  

    Unigene Cluster for MST4:

    Serine/threonine protein kinase MST4
    Hs.444247  [show with all ESTs]
    Unigene Representative Sequence: NM_016542
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394334(uc004ewk.1 uc004ewl.1 uc011mux.1 uc010nrj.1 uc004ewm.1)
    ENST00000481105 ENST00000354719 ENST00000394335 ENST00000496850
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MST4 (see all 10):
    hsa-miR-520d-5p hsa-miR-124 hsa-miR-19b hsa-miR-593* hsa-miR-518a-5p hsa-miR-506 hsa-miR-524-5p hsa-miR-19a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AB040057.2 AF231012.1 AF344882.1 AF344883.1 AK000556.1 AK027589.1 AK074837.1 AK075107.1 
    AK075150.1 AK303583.1 AK314356.1 AK316137.1 BC013856.2 BC017213.2 BC070056.1 BC098315.1 
    BC099737.1 BC099843.1 BC103503.1 BT020099.1 

    14 DOTS entries:

    DT.213153  DT.100704260  DT.92429277  DT.95374184  DT.121300074  DT.100708487  DT.121300089  DT.121300099 
    DT.121300076  DT.100641091  DT.102844002  DT.75109401  DT.95300794  DT.95374183 

    24/147 AceView cDNA sequences (see all 147):

    BP343845 CB528760 AA953567 BU753378 CB528737 BQ421016 AI299952 T39634 
    AF231012 AA371522 AI480355 AW297542 AW675066 BQ021967 AK075150 AK074837 
    BM801199 CN478958 BU678816 BP354207 AA992652 BP870472 BG110555 AW612302 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for MST4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                          -                 -                 -           -                                                                                 
    SP2:                          -                 -                 -           -                                                                       -     -   
    SP3:                          -                 -     -     -     -           -                                                                                 
    SP4:                                            -                 -           -                                         -     -                                 
    SP5:                          -                 -                 -           -     -     -     -     -     -     -     -     -     -     -                     

    ExUns: 14b ^ 15a · 15b · 15c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MST4 expression in normal human tissues (normalized intensities)      MST4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGGGTTA
    MST4 Expression
    About this image


    MST4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Membranous Facial Bones
             HyStem+BMP4-induced 4D20.8 cells
             sensory organ/ear/inner ear   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+BMP4-induced 4D20.8 cells
             skeleton/cranium   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             limb/hindlimb   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             ESI-017   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    See MST4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MST4

    SOURCE GeneReport for Unigene cluster: Hs.444247
        SABiosciences Custom PCR Arrays for MST4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MST4 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2610018G03Rik1 , 5 RIKEN cDNA 2610018G03 gene1, 5 91.11(n)1
    98.08(a)1
      X (27.50 cM)5
    704151  NM_133729.11  NP_598490.11 
     508410475 
    chicken
    (Gallus gallus)
    Aves MST41 serine/threonine protein kinase MST4 83.05(n)
    91.57(a)
      422231  NM_001031117.1  NP_001026288.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343780.1(23000-57140)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.196842 Transcribed sequence with strong similarity to protein more 81.92(n)    BX782246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mst41 serine/threonine protein kinase MST4 69.67(n)
    78.78(a)
      100151762  NM_001127477.1  NP_001120949.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51693
    GckIII1
    protein amino acid phosphorylation
    receptor signaling more3
    Germinal centre kinase III1
    82(a)3
    66.99(n)1
    77.27(a)1
      89E123
    420641  NM_142339.21  NP_650596.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gck-11 , 3 serine/threonine kinase3
    Protein GCK-11
    75(a)3
    64.84(n)1
    71.29(a)1
      V(8950405-8958008)3
    1792741  NM_072909.11  NP_505310.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIC16
    Protein kinase of the PAK/Ste20 family, required f...
    15(a)
    1 → many
    VIII(316572-319814)
    barley
    (Hordeum vulgare)
    Liliopsida Hv.101702 Transcribed sequence with moderate similarity to protein more 77.3(n)    BU969847.1 


    ENSEMBL Gene Tree for MST4 (if available)
    TreeFam Gene Tree for MST4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MST4 gene
    STK242  STK42  STK252  STK32  
    18/53 SIMAP similar genes for MST4 using alignment to 4 protein entries:     MST4_HUMAN (see all proteins) (see all similar genes):
    STK25    STK24    DKFZp686J1430    TAOK3    MAP4K5    STK3
    TAOK1    MAP4K1    PAK3    PAK2    MYO3A    STK10
    STK4/SLC36AL fusion    PAK1    STK4    MAP4K2    MINK1    PAK4

    MST4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MST4
    PGOHUM00000245864


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/676 SNPs in MST4 are shown (see all 676)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408454
    A gastric adenocarcinoma sample4--see VAR_0408452 G W mis40--------
    rs1432742111,2
    C--120559964(+) AAAGAC/TGTAAC 2 -- us2k10--------
    rs1483513521,2
    --120559968(+) ATGTAA/GCACAC 2 -- us2k10--------
    rs1414995451,2
    C--120560036(+) ATCAAC/TAAAAT 2 -- us2k10--------
    rs1903884621,2
    --131112207(+) TGGAGA/TATTCA 2 -- us2k10--------
    rs1508753131,2
    C--131112342(+) CCTACC/GTGAAT 2 -- us2k10--------
    rs125562171,2
    C,F,A,H--131112378(+) CTCTGC/GCCTCA 2 -- us2k14Minor allele frequency- G:0.09NS EA 418
    rs1440782741,2
    C--131112386(+) TCAAGA/GACCTA 2 -- us2k10--------
    rs1473566561,2
    --131112527(+) AGACAA/GGTCTT 2 -- us2k10--------
    rs1826300961,2
    --131112577(+) TGTGAC/TCTAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MST4 (131157245 - 131209971 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MST4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv425419CNV Loss16902084
    nsv515171CNV Gain21397061

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300547    OMIM disorders: --

    7 diseases for MST4:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    prostate cancer, progression of
    cerebritis    prostate cancer    prostatitis


    MST4 for disorders           About GeneDecksing


    Export disorders for MST4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MST4 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MST4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. (PubMed id 11741893)1, 2, 9 Dan I.... Pandey A. (2002)
    2. A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1, 2 Goudreault M....Gingras A.C. (2009)
    3. PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. (PubMed id 17360971)1, 2 Ma X....Ma D. (2007)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. (PubMed id 11641781)1, 2 Lin J.-L....Shih H.-M. (2001)
    8. Cloning and characterization of MST4, a novel Ste20-like kinase. (PubMed id 11306563)1, 2 Qian Z.... Rosner M.R. (2001)
    9. Functional analyses of human and zebrafish 18-amino a cid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein. (PubMed id 19370760)2, 9 Voss K....Felbor U. (2009)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51765 AceView: MST4 Ensembl:ENSG00000134602 euGenes: HUgn51765

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MST4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MST4 gene:
    Search GeneIP for patents involving MST4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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