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MST4 Gene

protein-coding   GIFtS: 57
GCID: GC0XP131158

Serine/Threonine Protein Kinase MST4


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MASK2 3 5     Mammalian Sterile 20-Like 42
Mammalian STE20-Like Protein Kinase 42 3     Serine/Threonine Protein Kinase MST42
Serine/Threonine-Protein Kinase MASK2 3     Serine/Threonine-Protein Kinase MST42
Mst3 And SOK1-Related Kinase2 3     MST-43
STE20-Like Kinase MST42 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    Entrez Gene: 517652   Ensembl: ENSG000001346027   OMIM: 3005475   UniProtKB: Q9P2893   

Export aliases for MST4 gene to outside databases

Previous GC identifers: GC0XP125803 GC0XP128003 GC0XP129102 GC0XP129862 GC0XP130882 GC0XP120561


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MST4 Gene:
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like
kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain
that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated
by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the
apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the
full-length nature of some of these variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for MST4 Gene:
MST4 is a protein-coding gene. Diseases associated with MST4 include cerebral cavernous malformations 3, and cavernous malformation. GO annotations related to this gene include magnesium ion binding and identical protein binding. An important paralog of this gene is STK24.

UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289
Function: Mediator of cell growth. Modulates apoptosis

Gene Wiki entry for MST4 (RP6-213H19.1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MST4 gene promoter:
         POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MST4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.2   Ensembl cytogenetic band:  Xq26.2   

MST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP131158:  view genomic region     (about GC identifiers)

Start:
131,157,245 bp from pter      End:
131,209,971 bp from pter
Size:
52,727 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase MST4  
Size: 416 amino acids; 46529 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer. Interacts with PDCD10 and GOLGA2. Interacts with CTTNBP2NL
6 PDB 3D structures from and Proteopedia for MST4:
3GGF (3D)        3W8I (3D)        4FZA (3D)        4FZD (3D)        4FZF (3D)        4GEH (3D)    
Secondary accessions: B2RAU2 Q3ZB77 Q8NC04 Q9BXC3 Q9BXC4
Alternative splicing: 3 isoforms:  Q9P289-1   Q9P289-2   Q9P289-3   

Explore the universe of human proteins at neXtProt for MST4: NX_Q9P289

Explore proteomics data for MST4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys159, Lys175, Lys233, Lys280
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MST4 (Q9P289) (see all 14)
     LLKHKFI  GITAIEL  LDYLHSE  WMAPEVI 


    See MST4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035917.1  NP_001035918.1  NP_057626.2  

    ENSEMBL proteins: 
     ENSP00000377867   ENSP00000418753   ENSP00000346755   ENSP00000377868   ENSP00000419702  
    Reactome Protein details: Q9P289

    MST4 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    MST4 Antibody Products:

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    MST4 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: serine/threonine-protein kinase MST4
    YSK subfamily

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9P289

    ProtoNet protein and cluster: Q9P289

    UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    MST4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MST4_HUMAN, Q9P289
    Function: Mediator of cell growth. Modulates apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly
    as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA11641781
    GO:0004672protein kinase activity IDA11641781
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI17360971
         
    MST4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MST4:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Decreased telomerase activity 

         1 MGI phenotypic allele for 2610018G03Rik (no phenotypes)

    MST4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MST4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MST4
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    miRNA
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    miRTarBase miRNAs that target MST4:
    hsa-mir-124-3p (MIRT022711), hsa-mir-26b-5p (MIRT029545)

    Block miRNA regulation of human, mouse, rat MST4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MST4 (see all 10):
    hsa-miR-520d-5p hsa-miR-124 hsa-miR-19b hsa-miR-593* hsa-miR-518a-5p hsa-miR-506 hsa-miR-524-5p hsa-miR-19a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MST4

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    GenScript: all cDNA clones in your preferred vector (see all 3): MST4 (NM_016542)
    Sino Biological Human cDNA Clone for MST4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MST4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MST4_HUMAN, Q9P289: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
    Note=Localizes to the Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol4
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005813centrosome IDA--

    MST4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MST4 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.74
    Apoptotic execution phase0.74
    2CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.38
    3LKB1 signaling events
    LKB1 signaling events
    4Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MST4
        Cytoskeletal Signaling

    1 BioSystems Pathway for MST4
        LKB1 signaling events


    1 Reactome Pathway for MST4
        Apoptotic cleavage of cellular proteins



    MST4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MST4
    Interactions:

        Search GeneGlobe Interaction Network for MST4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MST4 (Q9P2891, 2, 3 ENSP000003778674) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39Q9Y3761, 2, 3, ENSP000002584184EBI-618239,EBI-306905 MINT-8186588 MINT-8186788 MINT-8186577 MINT-8186607 MINT-8186820 MINT-8186804 I2D: score=1 STRING: ENSP00000258418
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-618239,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    ENSG00000215641P143733I2D: score=1 
    ENSG00000229006P143733I2D: score=1 
    ENSG00000234495P143733I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11641781
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0023014signal transduction by phosphorylation IBA--
    GO:0042981regulation of apoptotic process IDA11741893

    MST4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MST4

    3 HMDB Compounds for MST4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for MST4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MST4 gene (3 alternative transcripts): 
    NM_001042452.1  NM_001042453.1  NM_016542.3  

    Unigene Cluster for MST4:

    Serine/threonine protein kinase MST4
    Hs.444247  [show with all ESTs]
    Unigene Representative Sequence: NM_016542
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394334(uc004ewk.1 uc004ewl.1 uc011mux.1 uc010nrj.1 uc004ewm.1)
    ENST00000481105 ENST00000354719 ENST00000394335 ENST00000496850
    miRNA
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    hsa-miR-520d-5p hsa-miR-124 hsa-miR-19b hsa-miR-593* hsa-miR-518a-5p hsa-miR-506 hsa-miR-524-5p hsa-miR-19a
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      QuantiTect SYBR Green Assays in human, mouse, rat MST4
      QuantiFast Probe-based Assays in human, mouse, rat MST4

    Additional mRNA sequence: 

    AB040057.2 AF231012.1 AF344882.1 AF344883.1 AK000556.1 AK027589.1 AK074837.1 AK075107.1 
    AK075150.1 AK303583.1 AK314356.1 AK316137.1 BC013856.2 BC017213.2 BC070056.1 BC098315.1 
    BC099737.1 BC099843.1 BC103503.1 BT020099.1 

    14 DOTS entries:

    DT.213153  DT.100704260  DT.92429277  DT.95374184  DT.121300074  DT.100708487  DT.121300089  DT.121300099 
    DT.121300076  DT.100641091  DT.102844002  DT.75109401  DT.95300794  DT.95374183 

    Selected AceView cDNA sequences (see all 147):

    AI480355 AK074837 CB528737 AI822088 BP354207 BQ421016 AF344882 BP870472 
    AW612302 AA953567 BQ023784 AA992652 CB528760 BP379344 BU753378 T39634 
    AA814816 AI299952 AU279851 AK075150 AW236333 AA371522 AW297542 BM801199 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MST4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                          -                 -                 -           -                                                                                 
    SP2:                          -                 -                 -           -                                                                       -     -   
    SP3:                          -                 -     -     -     -           -                                                                                 
    SP4:                                            -                 -           -                                         -     -                                 
    SP5:                          -                 -                 -           -     -     -     -     -     -     -     -     -     -     -                     

    ExUns: 14b ^ 15a · 15b · 15c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MST4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGGGTTA
    MST4 Expression
    About this image


    MST4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Membranous Facial Bones
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
             Lens
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    MST4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MST4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444247
        Custom PCR Arrays for MST4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MST4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2610018G03Rik1 , 5 RIKEN cDNA 2610018G03 gene1, 5 91.11(n)1
    98.08(a)1
      X (27.50 cM)5
    704151  NM_133729.11  NP_598490.11 
     508410475 
    chicken
    (Gallus gallus)
    Aves MST41 serine/threonine protein kinase MST4 83.05(n)
    91.57(a)
      422231  NM_001031117.1  NP_001026288.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343780.1(23000-57140)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.196842 Transcribed sequence with strong similarity to protein more 81.92(n)    BX782246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mst41 serine/threonine protein kinase MST4 69.02(n)
    78.05(a)
      100151762  NM_001127477.1  NP_001120949.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51693
    GckIII1
    protein amino acid phosphorylation
    receptor signaling more3
    Germinal centre kinase III1
    82(a)3
    69.08(n)1
    82.97(a)1
      89E123
    420641  NM_142339.21  NP_650596.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gck-13 serine/threonine kinase 75(a)   V(8950405-8958008)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPS16
    Putative protein serine/threonine kinase expressed...
    30(a)
    1 → many
    IV(1485566-1487038) YDR523C
    barley
    (Hordeum vulgare)
    Liliopsida Hv.101702 Transcribed sequence with moderate similarity to protein more 77.3(n)    BU969847.1 


    ENSEMBL Gene Tree for MST4 (if available)
    TreeFam Gene Tree for MST4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MST4 gene
    STK242  STK42  STK252  STK32  
    Selected SIMAP similar genes for MST4 using alignment to 4 protein entries:     MST4_HUMAN (see all proteins) (see all similar genes):
    STK25    STK24    DKFZp686J1430    TAOK3    MAP4K5    STK3
    TAOK1    MAP4K1    PAK3    PAK2    MYO3A    STK10
    STK4/SLC36AL fusion    PAK1    STK4    MAP4K2    MINK1    PAK4

    MST4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MST4
    PGOHUM00000245864


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MST4 (see all 676)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408454
    A gastric adenocarcinoma sample4--see VAR_0408452 G W mis40--------
    rs1432742111,2
    C--120559964(+) AAAGAC/TGTAAC 2 -- us2k10--------
    rs1483513521,2
    --120559968(+) ATGTAA/GCACAC 2 -- us2k10--------
    rs1414995451,2
    C--120560036(+) ATCAAC/TAAAAT 2 -- us2k10--------
    rs1903884621,2
    --131112207(+) TGGAGA/TATTCA 2 -- us2k10--------
    rs1508753131,2
    C--131112342(+) CCTACC/GTGAAT 2 -- us2k10--------
    rs125562171,2
    C,F,A,H--131112378(+) CTCTGC/GCCTCA 2 -- us2k14Minor allele frequency- G:0.09NS EA 418
    rs1440782741,2
    C--131112386(+) TCAAGA/GACCTA 2 -- us2k10--------
    rs1473566561,2
    --131112527(+) AGACAA/GGTCTT 2 -- us2k10--------
    rs1826300961,2
    --131112577(+) TGTGAC/TCTAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MST4 (131157245 - 131209971 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MST4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv425419CNV Loss16902084
    nsv515171CNV Gain21397061

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MST4
    DNA2.0 Custom Variant and Variant Library Synthesis for MST4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300547    OMIM disorders: --

    8 diseases for MST4:    
    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    labyrinthitis
    cerebritis    prostate cancer    prostatitis    malaria


    MST4 for disorders           About GeneDecksing


    Export disorders for MST4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MST4 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with MST4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. (PubMed id 11741893)1, 2, 9 Dan I.... Pandey A. (J. Biol. Chem. 2002)
    2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1, 2 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)
    3. PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. (PubMed id 17360971)1, 2 Ma X....Ma D. (Mol. Biol. Cell 2007)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. (PubMed id 11641781)1, 2 Lin J.-L....Shih H.-M. (Oncogene 2001)
    8. Cloning and characterization of MST4, a novel Ste20-like kinase. (PubMed id 11306563)1, 2 Qian Z.... Rosner M.R. (J. Biol. Chem. 2001)
    9. Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein. (PubMed id 19370760)2, 9 Voss K.... Felbor U. (Hum. Mutat. 2009)
    10. Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. (PubMed id 24374310)1 Chen C....Turk B.E. (Mol. Cell 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51765 AceView: MST4 Ensembl:ENSG00000134602 euGenes: HUgn51765

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MST4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MST4 gene:
    Search GeneIP for patents involving MST4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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