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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MST4 Gene

protein-coding GIFtS: 53
GCID: GC0XP131158

MST4

Explore 7 diseases affiliated with
MST4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mammalian STE20-Like Protein Kinase 4² ³		Mammalian Sterile 20-Like 4²
Serine/Threonine-Protein Kinase MASK² ³		Serine/Threonine Protein Kinase MST4²
MASK² ³		Serine/Threonine-Protein Kinase MST4²
Mst3 And SOK1-Related Kinase² ³		MST-4³
STE20-Like Kinase MST4² ³		EC 2.7.11⁸
EC 2.7.11.1³ ⁸

External Ids:	Entrez Gene: 51765²	Ensembl: ENSG00000134602⁷	OMIM: 300547⁵	UniProtKB: Q9P289³

Export aliases for MST4 gene to outside databases

Previous GC identifers: GC0XP125803 GC0XP128003 GC0XP129102 GC0XP129862 GC0XP130882 GC0XP120561

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MST4:

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like

kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that

mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by

binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic

pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length

nature of some of these variants has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289

Function: Mediator of cell growth. Modulates apoptosis

Gene Wiki entry for MST4 (RP6-213H19.1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MST4 gene promoter:
POU2F1 POU2F1a FOXJ2 (long isoform) FOXJ2 Ik-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MST4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.2 Ensembl cytogenetic band: Xq26.2

MST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST4 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP131158: view genomic region (about GC identifiers)

Start:	131,157,245 bp from pter	End:	131,209,971 bp from pter
Size:	52,727 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase MST4

Size: 416 amino acids; 46529 Da

Cofactor: Magnesium (By similarity)

Subunit: Homodimer. Interacts with PDCD10 and GOLGA2

Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Note=Localizes to the Golgi apparatus

1 PDB 3D structure from and Proteopedia for MST4:

3GGF (3D)

Secondary accessions: B2RAU2 Q3ZB77 Q8NC04 Q9BXC3 Q9BXC4

Alternative splicing: 3 isoforms: Q9P289-1 Q9P289-2 Q9P289-3

Explore the universe of human proteins at neXtProt for MST4: NX_Q9P289

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P289

4/14 DME Specific Peptides for MST4 (Q9P289) (see all 14)

LLKHKFI

GITAIEL

LDYLHSE

WMAPEVI

MST4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001035917.1 NP_001035918.1 NP_057626.2

ENSEMBL proteins:

ENSP00000377867 ENSP00000418753 ENSP00000346755 ENSP00000377868 ENSP00000419702

Reactome Protein details: Q9P289
Human Recombinant Protein Products for MST4:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for MST4
	Novus Biologicals MST4 Proteins Novus Biologicals MST4 Lysates
	Sino Biological Recombinant Protein for MST4
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005829	cytosol	TAS	--

MST4 for ontologies About GeneDecksing

MST4 Antibody Products:

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Assay Products for MST4:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MST4 for domains About GeneDecksing

4 InterPro domains/families:

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q9P289

ProtoNet protein and cluster: Q9P289

UniProtKB/Swiss-Prot: MST4_HUMAN, Q9P289

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MST4_HUMAN, Q9P289

Function: Mediator of cell growth. Modulates apoptosis

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a

consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage

Enzyme Numbers (IUBMB): EC 2.7.11.1¹ ² EC 2.7.11²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	11641781
GO:0004672	protein kinase activity	IDA	11641781
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005515	protein binding	IPI	18782753
GO:0005524	ATP binding	IDA	11641781

MST4 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for MST4:

Decreased focal adhesion (FA)

Decreased nuclei size in G2M

Decreased telomerase activity

1 MGI phenotypic allele

for 2610018G03Rik (no phenotypes)

MST4 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MST4

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MST4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MST4
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MST4 (see all 10):
		hsa-miR-520d-5p hsa-miR-124 hsa-miR-19b hsa-miR-593* hsa-miR-518a-5p hsa-miR-506 hsa-miR-524-5p hsa-miR-19a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MST4 (see all 4) OriGene shRNA RFP: MST4 OriGene siRNA: MST4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MST4
		Sirion Biotech Custom design and validation of potent shRNA sequences against MST4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MST4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 3): MST4 (NM_016542)
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		Sirion Biotech Customized stable knockdown cell line services for MST4 Sirion Biotech Customized inducible knockdown cell line services for MST4 Sirion Biotech Customized stable overexpressing cell line services for MST4 Sirion Biotech Customized inducible overexpressing cell line services for MST4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic cleavage of cellular proteins

Apoptotic cleavage of cellular proteins

1.00

Apoptotic execution phase

0.73

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

LKB1 signaling events

LKB1 signaling events

1.00

Ubiquitinated Orc1 is degraded by the proteasome

Apoptosis

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for MST4

Cytoskeletal Signaling

1 BioSystems Pathway for MST4

LKB1 signaling events

3 Reactome Pathways for MST4

	Apoptotic execution phase
	Apoptotic cleavage of cellular proteins
	Apoptosis

MST4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MST4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for MST4 (Q9P289^{1, 2, 3} ENSP00000377867⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAB39	Q9Y376²^,³, ENSP00000258418⁴	MINT-8186588 MINT-8186788 MINT-8186577 MINT-8186607 MINT-8186820 MINT-8186804 I2D: score=1 STRING: ENSP00000258418
CTTNBP2NL	Q9P2B4¹^,³, ENSP00000271277⁴	EBI-1774248,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
FAM40A	Q5VSL9¹^,³	EBI-1774248,EBI-1773588 I2D: score=2
STRIP1	Q5VSL9¹^,³, ENSP00000358810⁴	EBI-1774248,EBI-1773588 I2D: score=2 STRING: ENSP00000358810
MOB4	Q9Y3A3³, ENSP00000315702⁴	I2D: score=3 STRING: ENSP00000315702

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IDA	11641781
GO:0006915	apoptotic process	TAS	--
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	TAS	--
GO:0042981	regulation of apoptotic process	IDA	11741893

MST4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MST4

3 HMDB Compounds for MST4 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 DrugBank Compound for MST4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about MST4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MST4 gene (3 alternative transcripts):

NM_001042452.1 NM_001042453.1 NM_016542.3

Unigene Cluster for MST4:

Serine/threonine protein kinase MST4

Hs.444247 [show with all ESTs]

Unigene Representative Sequence: NM_016542

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394334(uc004ewk.1 uc004ewl.1 uc011mux.1 uc010nrj.1 uc004ewm.1)

ENST00000481105 ENST00000354719 ENST00000394335 ENST00000496850

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MST4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MST4
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MST4 (see all 10):
		hsa-miR-520d-5p hsa-miR-124 hsa-miR-19b hsa-miR-593* hsa-miR-518a-5p hsa-miR-506 hsa-miR-524-5p hsa-miR-19a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MST4 (see all 4) OriGene shRNA RFP: MST4 OriGene siRNA: MST4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MST4
		Sirion Biotech Custom design and validation of potent shRNA sequences against MST4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MST4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MST4 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MST4 (NM_016542)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MST4

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MST4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST4

Additional cDNA sequence:

AB040057.2 AF231012.1 AF344882.1 AF344883.1 AK000556.1 AK027589.1 AK074837.1 AK075107.1

AK075150.1 AK303583.1 AK314356.1 AK316137.1 BC013856.2 BC017213.2 BC070056.1 BC098315.1

BC099737.1 BC099843.1 BC103503.1 BT020099.1

14 DOTS entries:

DT.213153 DT.100704260 DT.92429277 DT.95374184 DT.121300074 DT.100708487 DT.121300089 DT.121300099

DT.121300076 DT.100641091 DT.102844002 DT.75109401 DT.95300794 DT.95374183

24/147 AceView cDNA sequences (see all 147):

BG110555 AI822088 AW675066 CN478958 BQ021967 AW297484 BU678816 AW297542

AF231012 AA814816 AA992652 AW612302 T39634 CB528760 BQ023784 AA953567

BP354207 BU753378 BQ421016 AF344882 AA371522 AU279851 AI299952 AK075150

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for MST4 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·
SP1:									-						-						-				-
SP2:									-						-						-				-																								-		-
SP3:									-						-		-		-		-				-
SP4:															-						-				-														-		-
SP5:									-						-						-				-		-		-		-		-		-		-		-		-		-		-

ExUns:	14b	^	15a	·	15b	·	15c
SP1:
SP2:
SP3:
SP4:
SP5:

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MST4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATGGGTTA

About this image

MST4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Myotome

Limb Muscle Progenitor Cells

Skeletal Muscle

Hyoid Arch Muscles

Muscle Progenitor Cells

Skeletal Muscle

Mandibular Arch Muscles

Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See MST4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MST4

SOURCE GeneReport for Unigene cluster: Hs.444247

SABiosciences Custom PCR Arrays for MST4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MST4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MST4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MST4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MST4 gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MST4¹	serine/threonine protein kinase MST4	83.05(n) 91.57(a)		422231 NM_001031117.1 NP_001026288.1
lizard (Anolis carolinensis)	Reptilia	--	--	88(a)	1 ↔ 1	GL343780.1(35527-57140)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.19684²	Transcribed sequence with strong similarity to protein more	81.92(n)		BX782246.1
zebrafish (Danio rerio)	Actinopterygii	mst4¹	serine/threonine protein kinase MST4	69.67(n) 78.78(a)		100151762 NM_001127477.1 NP_001120949.1
fruit fly (Drosophila melanogaster)	Insecta	CG5169³ GckIII¹	protein amino acid phosphorylation receptor signaling more³ Germinal centre kinase III¹	82(a)³ 66.99(n)¹ 77.27(a)¹		89E12³ 42064¹ NM_142339.2¹ NP_650596.1¹
worm (Caenorhabditis elegans)	Secernentea	gck-1^{1 , 3}	serine/threonine kinase³ Protein GCK-1¹	75(a)³ 64.84(n)¹ 71.29(a)¹		V(8950405-8958008)³ 179274¹ NM_072909.1¹ NP_505310.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G15220⁶ ATMAP4K ALPHA1⁶	map 4 kinase alpha1	28(a) 28(a)	many ↔ many many ↔ many	3(5126597-5132306) 1(19813804-19819564)
rice (Oryza sativa)	Liliopsida	--	STE_PAK_Ste20_MST_like.1 - STE kinases include hom...	28(a)	1 → many	7(19257731-19267291)

ENSEMBL Gene Tree for MST4 (if available)
TreeFam Gene Tree for MST4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MST4 gene

STK24² STK4² STK3² STK25²

18/53 SIMAP similar genes for MST4 using alignment to 4 protein entries: MST4_HUMAN (see all proteins) (see all similar genes):

STK25 STK24 DKFZp686J1430 TAOK3 MAP4K5 STK3

TAOK1 MAP4K1 PAK3 PAK2 MYO3A STK10

STK4/SLC36AL fusion PAK1 STK4 MAP4K2 MINK1 PAK4

MST4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MST4
PGOHUM00000245864

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190388462^1,2		--	131155266(+)	`TGGAGA/TATTCA`	2	--	us2k¹		0	--	--	--	--
rs150875313^1,2		--	131155401(+)	`CCTACC/GTGAAT`	2	--	us2k¹		0	--	--	--	--
rs12556217^1,2	C,F,A,H	--	131155437(+)	`CTCTGC/GCCTCA`	2	--	us2k¹		4		NS EA	418
rs144078274^1,2		--	131155445(+)	`TCAAGA/GACCTA`	2	--	us2k¹		0	--	--	--	--
rs147356656^1,2		--	131155586(+)	`AGACAA/GGTCTT`	2	--	us2k¹		0	--	--	--	--
rs182630096^1,2		--	131155636(+)	`TGTGAC/TCTAAA`	3	--	us2k¹		0	--	--	--	--
rs187913493^1,2		--	131155871(+)	`TGAAGG/TGCTGG`	3	--	us2k¹		0	--	--	--	--
rs55958822^1,2	C	--	131155878(+)	`CTGGAC/TTTGGG`	3	--	us2k¹		0	--	--	--	--
rs191183559^1,2		--	131156187(+)	`CCATTA/TATAAT`	3	--	us2k¹		0	--	--	--	--
rs149906051^1,2		--	131156276(+)	`AGGCCC/TCCCAC`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MST4 (131157245 - 131209971 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MST4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MST4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MST4 for disorders           About GeneDecksing

OMIM gene information: 300547    OMIM disorders: --

7 diseases for MST4:    About MalaCards

cerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3 prostate cancer, progression of

cerebritis prostate cancer prostatitis

Export disorders for MST4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MST4 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with MST4)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. (PubMed id 11741893)^{1, 2, 9} Dan I.... Pandey A. (2002)
PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. (PubMed id 17360971)^{1, 2} Ma X....Ma D. (2007)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. (PubMed id 11641781)^{1, 2} Lin J.-L....Shih H.-M. (2001)
Cloning and characterization of MST4, a novel Ste20-like kinase. (PubMed id 11306563)^{1, 2} Qian Z.... Rosner M.R. (2001)
Functional analyses of human and zebrafish 18-amino a cid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein. (PubMed id 19370760)^{2, 9} Voss K....Felbor U. (2009)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51765

AceView: MST4

Ensembl:ENSG00000134602

euGenes: HUgn51765

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MST4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MST4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MST4 gene:
Search GeneIP for patents involving MST4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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