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Aliases for MST1R Gene

Aliases for MST1R Gene

  • Macrophage Stimulating 1 Receptor 2 3
  • RON 3 4 6
  • PTK8 Protein Tyrosine Kinase 8 2 3
  • C-Met-Related Tyrosine Kinase 2 3
  • MSP Receptor 3 4
  • EC 2.7.10.1 4 63
  • P185-Ron 3 4
  • CDw136 3 4
  • PTK8 3 4
  • Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine Kinase) 3
  • Macrophage-Stimulating Protein Receptor 3
  • Protein-Tyrosine Kinase 8 4
  • Soluble RON Variant 1 3
  • Soluble RON Variant 2 3
  • Soluble RON Variant 3 3
  • Soluble RON Variant 4 3
  • MST1R Variant RON30 3
  • MST1R Variant RON62 3
  • RON Variant E2E3 3
  • RON Variant 21 3
  • CD136 Antigen 4
  • EC 2.7.10 63
  • CD136 3

External Ids for MST1R Gene

Previous Symbols for MST1R Gene

  • RON
  • PTK8

Summaries for MST1R Gene

Entrez Gene Summary for MST1R Gene

  • This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]

GeneCards Summary for MST1R Gene

MST1R (Macrophage Stimulating 1 Receptor) is a Protein Coding gene. Diseases associated with MST1R include renal oncocytoma and pancreatic cancer. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include enzyme binding and macrophage colony-stimulating factor receptor activity. An important paralog of this gene is MET.

UniProtKB/Swiss-Prot for MST1R Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Gene Wiki entry for MST1R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MST1R Gene

Genomics for MST1R Gene

Genomic Location for MST1R Gene

Start:
49,887,002 bp from pter
End:
49,903,873 bp from pter
Size:
16,872 bases
Orientation:
Minus strand

Genomic View for MST1R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MST1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MST1R Gene

Regulatory Elements for MST1R Gene

Proteins for MST1R Gene

  • Protein details for MST1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04912-RON_HUMAN
    Recommended name:
    Macrophage-stimulating protein receptor
    Protein Accession:
    Q04912
    Secondary Accessions:
    • B5A944
    • B5A945
    • B5A946
    • B5A947

    Protein attributes for MST1R Gene

    Size:
    1400 amino acids
    Molecular mass:
    152271 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion.

    Three dimensional structures from OCA and Proteopedia for MST1R Gene

    Alternative splice isoforms for MST1R Gene

neXtProt entry for MST1R Gene

Proteomics data for MST1R Gene at MOPED

Selected DME Specific Peptides for MST1R Gene

Post-translational modifications for MST1R Gene

  • Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site.
  • Proteolytic processing yields the two subunits
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn66, Asn419, Asn458, Asn488, Asn654, Asn720, Asn841, and Asn897

Domains for MST1R Gene

Suggested Antigen Peptide Sequences for MST1R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04912

UniProtKB/Swiss-Prot:

RON_HUMAN
Domain:
  • Contains 3 IPT/TIG domains.:
    • Q04912
  • Contains 1 protein kinase domain.:
    • Q04912
  • Contains 1 Sema domain.:
    • Q04912
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.:
    • Q04912
genes like me logo Genes that share domains with MST1R: view

Function for MST1R Gene

Molecular function for MST1R Gene

GENATLAS Biochemistry: macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development of epithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk) homolog,conferring susceptibility to friend virus induced erythroleukemia in mice
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Enzyme Numbers (IUBMB) for MST1R Gene

Gene Ontology (GO) - Molecular Function for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity --
GO:0004872 receptor activity --
GO:0005011 macrophage colony-stimulating factor receptor activity TAS 9045873
genes like me logo Genes that share ontologies with MST1R: view
genes like me logo Genes that share phenotypes with MST1R: view

Animal Models for MST1R Gene

MGI Knock Outs for MST1R:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MST1R Gene

Localization for MST1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for MST1R Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MST1R Gene COMPARTMENTS Subcellular localization image for MST1R gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane TAS 7939629
GO:0009986 cell surface IDA 19581412
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MST1R: view

Pathways for MST1R Gene

genes like me logo Genes that share pathways with MST1R: view

Pathways by source for MST1R Gene

Gene Ontology (GO) - Biological Process for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006928 movement of cell or subcellular component TAS 9045873
GO:0006952 defense response TAS 9045873
GO:0007165 signal transduction TAS 7939629
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
genes like me logo Genes that share ontologies with MST1R: view

Compounds for MST1R Gene

(2) HMDB Compounds for MST1R Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) IUPHAR Ligand for MST1R Gene

Ligand Type Action Affinity Pubmed IDs
macrophage stimulating protein 1 None None

(5) Novoseek inferred chemical compound relationships for MST1R Gene

Compound -log(P) Hits PubMed IDs
tyrosine 76.6 61
wortmannin 48.9 2
pd 98,059 17.1 1
phosphatidylinositol 11.8 1
serine 11.3 1
genes like me logo Genes that share compounds with MST1R: view

Transcripts for MST1R Gene

Unigene Clusters for MST1R Gene

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MST1R Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MST1R Gene

GeneLoc Exon Structure for
MST1R
ECgene alternative splicing isoforms for
MST1R

Expression for MST1R Gene

mRNA expression in normal human tissues for MST1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MST1R Gene

This gene is overexpressed in Colon - Transverse (7.7), Stomach (6.1), Skin - Sun Exposed (Lower leg) (5.4), and Skin - Not Sun Exposed (Suprapubic) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MST1R Gene

SOURCE GeneReport for Unigene cluster for MST1R Gene Hs.517973

mRNA Expression by UniProt/SwissProt for MST1R Gene

Q04912-RON_HUMAN
Tissue specificity: Expressed in colon, skin, lung and bone marrow.
genes like me logo Genes that share expressions with MST1R: view

Orthologs for MST1R Gene

This gene was present in the common ancestor of animals.

Orthologs for MST1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MST1R 35
  • 99.55 (n)
  • 99.5 (a)
MST1R 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MST1R 35
  • 82.68 (n)
  • 81.25 (a)
MST1R 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MST1R 35
  • 82.54 (n)
  • 80.63 (a)
MST1R 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mst1r 35
  • 78.74 (n)
  • 76.39 (a)
Mst1r 16
Mst1r 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MST1R 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MST1R 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mst1r 35
  • 78.29 (n)
  • 76.65 (a)
chicken
(Gallus gallus)
Aves MST1R 35
  • 58.92 (n)
  • 49.28 (a)
MST1R 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MST1R 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496572 35
  • 52.33 (n)
  • 45.94 (a)
zebrafish
(Danio rerio)
Actinopterygii mst1ra 36
  • 39 (a)
OneToMany
mst1rb 35
  • 49.59 (n)
  • 43.24 (a)
mst1rb 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hop 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea svh-2 36
  • 20 (a)
OneToMany
old-2 37
  • 32 (a)
F11E6.8 37
  • 49 (a)
kin-16 37
  • 31 (a)
T14E8.1a 37
  • 36 (a)
F09A5.2 37
  • 33 (a)
old-1 37
  • 30 (a)
T14E8.1b 37
  • 40 (a)
W04G5.10 37
  • 34 (a)
kin-23 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for MST1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MST1R Gene

ENSEMBL:
Gene Tree for MST1R (if available)
TreeFam:
Gene Tree for MST1R (if available)

Paralogs for MST1R Gene

Paralogs for MST1R Gene

genes like me logo Genes that share paralogs with MST1R: view

Variants for MST1R Gene

Sequence variations from dbSNP and Humsavar for MST1R Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1062633 - 49,887,507(-) CCTTC(A/G)GAGTA reference, missense, nc-transcript-variant
rs2280406 -- 49,904,003(-) CAGGC(C/T)TCCAA upstream-variant-2KB
rs4395393 -- 49,891,181(-) AGAGT(A/T)GCTGG intron-variant
rs5030975 -- 49,887,514(-) CGACC(C/T)ACCTT reference, synonymous-codon, nc-transcript-variant
rs6795703 -- 49,892,782(+) aaccc(C/T)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MST1R Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876766 CNV Loss 21882294
nsv876767 CNV Loss 21882294

Relevant External Links for MST1R Gene

HapMap Linkage Disequilibrium report
MST1R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MST1R Gene

Disorders for MST1R Gene

(18) Novoseek inferred disease relationships for MST1R Gene

Disease -log(P) Hits PubMed IDs
metastasis 44.6 18
breast carcinoma 41.6 5
tumors 38.6 32
cancer 35.9 30
pancreatic cancer 31 8

Relevant External Links for MST1R

Genetic Association Database (GAD)
MST1R
Human Genome Epidemiology (HuGE) Navigator
MST1R
genes like me logo Genes that share disorders with MST1R: view

No data available for UniProtKB/Swiss-Prot for MST1R Gene

Publications for MST1R Gene

  1. A novel putative receptor protein tyrosine kinase of the met family. (PMID: 8386824) Ronsin C. … Breathnach R. (Oncogene 1993) 2 3 4 23
  2. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. (PMID: 7939629) Wang M.-H. … Breatnach R. (Science 1994) 3 4 23
  3. c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. (PMID: 12802274) Penengo L. … Gaudino G. (Oncogene 2003) 3 4 23
  4. Interplay between scatter factor receptors and B plexins controls invasive growth. (PMID: 15184888) Conrotto P. … Giordano S. (Oncogene 2004) 3 4 23
  5. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. (PMID: 8062829) Gaudino G. … Comoglio P.M. (EMBO J. 1994) 3 4 23

Products for MST1R Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epithelial to Mesenchymal Transition (EMT) in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MST1R
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MST1R
    • Block miRNA regulation of MST1R using miScript Target Protectors

    Sources for MST1R Gene

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