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MST1R Gene

protein-coding   GIFtS: 68
GCID: GC03M049924

Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine...

(Previous name: PTK8 protein tyrosine kinase 8)
(Previous symbols: RON, PTK8)
  See MST1R-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine Kinase)1 2     MST1R Variant RON302
RON1 2 3 5     MST1R Variant RON622
PTK81 2 3     RON Variant 212
PTK8 Protein Tyrosine Kinase 81 2     RON Variant E2E32
CDw1362 3     Soluble RON Variant 12
MSP Receptor2 3     Soluble RON Variant 22
p185-Ron2 3     Soluble RON Variant 32
EC 2.7.10.13 8     Soluble RON Variant 42
CD1362     CD136 Antigen3
C-Met-Related Tyrosine Kinase2     Protein-Tyrosine Kinase 83
Macrophage-Stimulating Protein Receptor2     EC 2.7.108

External Ids:    HGNC: 73811   Entrez Gene: 44862   Ensembl: ENSG000001640787   OMIM: 6001685   UniProtKB: Q049123   

Export aliases for MST1R gene to outside databases

Previous GC identifers: GC03P050091 GC03P050215 GC03M049778 GC03M049884 GC03M049885 GC03M049899


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MST1R Gene:
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity.
The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by
proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon
stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of
the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript
variants encoding different isoforms with different structural and biochemical properties have been described
(PMID:8816464). (provided by RefSeq, Oct 2011)

GeneCards Summary for MST1R Gene:
MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)) is a protein-coding gene. Diseases associated with MST1R include renal oncocytoma, and pancreatic cancer. GO annotations related to this gene include macrophage colony-stimulating factor receptor activity and enzyme binding. An important paralog of this gene is AXL.

UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and
differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular
domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts
with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON
leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON
signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as
survival at the wound site. Plays also a role in the innate immune response by regulating the migration and
phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and
proliferation in response to growth factors other than MST1 ligand

Gene Wiki entry for MST1R Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MST1R gene promoter:
         E2F   E2F-1   STAT3   E2F-2   STAT5A   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMST1R promoter sequence
   Search Chromatin IP Primers for MST1R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MST1R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

MST1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1R gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049924:  view genomic region     (about GC identifiers)

Start:
49,924,435 bp from pter      End:
49,941,306 bp from pter
Size:
16,872 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 (See protein sequence)
Recommended Name: Macrophage-stimulating protein receptor precursor  
Size: 1400 amino acids; 152271 Da
Subunit: Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with
and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1,
PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion
2 PDB 3D structures from and Proteopedia for MST1R:
3PLS (3D)        4FWW (3D)    
Secondary accessions: B5A944 B5A945 B5A946 B5A947
Alternative splicing: 6 isoforms:  Q04912-1   Q04912-2   Q04912-3   Q04912-4   Q04912-5   Q04912-6   (Lacks part of the extracellular domain, oligomerizes and is constitutively activated)

Explore the universe of human proteins at neXtProt for MST1R: NX_Q04912

Explore proteomics data for MST1R at MOPED

Post-translational modifications: 

  • Proteolytic processing yields the two subunits1
  • Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further
    phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site1
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation1
  • Glycosylation2 at Asn66, Asn419, Asn458, Asn488, Asn654, Asn720, Asn841, Asn897
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MST1R (Q04912) (see all 9)
     FVHRDLA  QVARGME  QPEYCPD  RDLAARN 


    See MST1R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231866.1  NP_002438.2  

    ENSEMBL proteins: 
     ENSP00000296474   ENSP00000407926   ENSP00000341325   ENSP00000393294   ENSP00000414792  

    MST1R Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for MST1R 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
    Met family
    HGF (hepatocyte growth factor) receptor family

    Selected InterPro protein domains (see all 13):
     IPR017441 Protein_kinase_ATP_BS
     IPR014756 Ig_E-set
     IPR002909 IPT
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q04912

    ProtoNet protein and cluster: Q04912

    2 Blocks protein domains:
    IPB002909 Cell surface receptor IPT/TIG
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 3 IPT/TIG domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Sema domain


    Find genes that share domains with MST1R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RON_HUMAN, Q04912
    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
    binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and
    differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular
    domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts
    with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON
    leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON
    signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as
    survival at the wound site. Plays also a role in the innate immune response by regulating the migration and
    phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and
    proliferation in response to growth factors other than MST1 ligand
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the
    kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus
    increasing the kinase activity

         Genatlas biochemistry entry for MST1R:
    macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development of
    epithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk)
    homolog,conferring susceptibility to friend virus induced erythroleukemia in mice

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0004872receptor activity ----
    GO:0005011macrophage colony-stimulating factor receptor activity TAS9045873
         
    Find genes that share ontologies with MST1R           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for MST1R:
     Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mst1r):
     endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with MST1R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MST1R: Mst1rtm1Sjd Mst1rtm1.1Sew

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MST1R
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MST1R

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RON_HUMAN, Q04912: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS7939629
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with MST1R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MST1R About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71


    Find genes that share SuperPaths with MST1R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MST1R (see all 30)
        MAPK Signaling
    MSP-RON Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for MST1R
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 BioSystems Pathways for MST1R
        Alpha6-Beta4 Integrin Signaling Pathway
    a6b1 and a6b4 Integrin signaling
    amb2 Integrin signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including MST1R: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MST1R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MST1R (Q049121, 2, 3 ENSP000002964744) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNB1O431571, 3, ENSP000002964404EBI-2637518,EBI-1111488 I2D: score=1 STRING: ENSP00000296440
    PLXNB3Q9ULL41, 3, ENSP000003553784EBI-2637518,EBI-311073 I2D: score=1 STRING: ENSP00000355378
    CBLP226812, 3, ENSP000002640334MINT-6539679 I2D: score=2 STRING: ENSP00000264033
    YWHAZP631042, 3, ENSP000003095034MINT-8006508 I2D: score=2 STRING: ENSP00000309503
    YWHAQP273482, 3, ENSP000002380814MINT-8006465 I2D: score=2 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006928cellular component movement TAS9045873
    GO:0006952defense response TAS9045873
    GO:0007165signal transduction TAS7939629
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--

    Find genes that share ontologies with MST1R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MST1R (RON)

    2 HMDB Compounds for MST1R    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 IUPHAR Ligand for MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase))    About this table
    LigandTypeActionAffinityPubmed IDs
    macrophage stimulating protein 1
    NoneNone--

    5 Novoseek inferred chemical compound relationships for MST1R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 76.6 79 18593918 (4), 19307182 (3), 15827676 (2), 11332718 (2) (see all 47)
    wortmannin 48.9 2 9794431 (1), 14505491 (1)
    pd 98,059 17.1 1 15001985 (1)
    phosphatidylinositol 11.8 3 19224914 (1)
    serine 11.3 1 14505491 (1)



    Find genes that share compounds with MST1R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MST1R gene (2 alternative transcripts): 
    NM_001244937.1  NM_002447.2  

    Unigene Cluster for MST1R:

    Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
    Hs.517973  [show with all ESTs]
    Unigene Representative Sequence: NM_002447
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296474 ENST00000411578(uc003cxy.4 uc011bdc.2 uc011bde.1 uc011bdf.1 uc011bdg.2)
    ENST00000344206 ENST00000434765 ENST00000440292 ENST00000463789 ENST00000490053
    ENST00000467110 ENST00000468525 ENST00000493535 ENST00000485044 ENST00000497001

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    Additional mRNA sequence: 

    AK303234.1 EU826582.1 EU826583.1 EU826584.1 EU826585.1 HQ908652.1 JN983806.1 X70040.1 

    7 DOTS entries:

    DT.211894  DT.120879705  DT.91904328  DT.100754685  DT.92417911  DT.96086513  DT.97837134 

    Selected AceView cDNA sequences (see all 72):

    AW179110 BX505902 AI659677 BG823879 BU542597 BX280864 AI679494 BG289902 
    BU541700 AW604980 BM048043 BM790561 BU500594 BQ919273 AI651503 BX479000 
    BM044732 BM047000 BQ900191 NM_002447 BF094070 BM795098 BM044054 X70040 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MST1R    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                    -                       -     -           -                                             
    SP2:                                                                    -     -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                             
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MST1R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MST1R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATGGA
    MST1R Expression
    About this image


    MST1R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Bone (Muscoskeletal System)
             Endochondral Facial Bones
     
     Colon (Gastrointestinal Tract)
     
     Stomach (Gastrointestinal Tract)
     
     Prostate (Endocrine System)
    MST1R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MST1R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517973

    UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
    Tissue specificity: Expressed in colon, skin, lung and bone marrow

        Pathway & Disease-focused RT2 Profiler PCR Array including MST1R: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MST1R
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MST1R
    QuantiTect SYBR Green Assays in human, mouse, rat MST1R
    QuantiFast Probe-based Assays in human, mouse, rat MST1R
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for MST1R gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mst1r1 , 5 macrophage stimulating 1 receptor (c-met-related tyrosine more1, 5 78.74(n)1
    76.39(a)1
      9 (59.07 cM)5
    198821  NM_009074.21  NP_033100.21 
     1079068895 
    chicken
    (Gallus gallus)
    Aves MST1R1 macrophage stimulating 1 receptor (c-met-related tyrosine more 58.92(n)
    49.28(a)
      427573  NM_001031463.1  NP_001026634.1 
    lizard
    (Anolis carolinensis)
    Reptilia MST1R6
    macrophage stimulating 1 receptor (c-met-related t...
    39(a)
    1 ↔ 1
    2(147875611-147953639)
    African clawed frog
    (Xenopus laevis)
    Amphibia D87758.12   -- 75.07(n)    D87758.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mst1rb1 macrophage stimulating 1 receptor (c-met-related tyrosine more 49.59(n)
    43.24(a)
      100134855  XM_002663812.2  XP_002663858.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F11E6.83 Eukaryotic protein kinase domain 49(a)
    (best of 9)
      IV(17444692-17450635)   --


    ENSEMBL Gene Tree for MST1R (if available)
    TreeFam Gene Tree for MST1R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MST1R gene
    AXL2  MET2  RYK2  TYRO32  MERTK2  
    Selected SIMAP similar genes for MST1R using alignment to 4 protein entries:     RON_HUMAN (see all proteins) (see all similar genes):
    RON    FLT4    EPHA2    FLT1    BTK kinase deficient isoform 6    ABL1
    tec    SRC    AXL    CSK    EZR-ROS1    LRIG3(NM_001136051)-ROS1
    LRIG3(NM_153377)-ROS1    R32    R34    SLC34A2-ROS1    TPM3-ROS1    FES

    Find genes that share paralogs with MST1R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MST1R (see all 571)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816546901,2
    --49855997(+) TATGCC/TCCAGA 2 -- ds50010--------
    rs738341181,2
    C,F--49856090(+) GGGAAA/CGGGGA 2 -- ds50012Minor allele frequency- C:0.13WA 120
    rs1434942441,2
    --49856321(+) CACTGG/TTTCTG 2 -- ds50010--------
    rs1462590721,2
    --49856339(+) TTCCCC/TGGTTG 2 -- ds50010--------
    rs76152401,2
    C,F,H--49856340(+) tccccG/Agttga 2 -- ds50015Minor allele frequency- A:0.02NS EA 540
    rs1393280941,2
    --49856434(+) TCACAC/TTGTTT 2 -- ds50010--------
    rs117131931,2
    C,F,A,H--49856436(+) ACACTG/ATTTGC 2 -- ds500128Minor allele frequency- A:0.38NS EA NA WA CSA 2627
    rs1440796611,2
    C--49856462(+) AATAGG/TCATTT 2 -- ut310--------
    rs793280511,2
    C,F--49856497(+) GTGTTG/TGTGTG 2 -- ut311Minor allele frequency- T:0.04EA 120
    rs1482584531,2
    C--49856763(+) GGGCCG/AAGGAG 4 /R /W mis11Minor allele frequency- A:0.00NA 4548
    rs1413389641,2
    C,F--49856775(+) CTCTGA/TGAGTG 4 T S mis11Minor allele frequency- T:0.00NA 4552
    rs2022198891,2
    C--49856789(+) GGGGCC/TGGCGT 4 Q R mis10--------
    rs1378827711,2
    C,F--49856801(+) CATTCC/ACTGGC 4 /G /V mis12Minor allele frequency- A:0.00NA EU 5841
    rs126341021,2
    C,H--49856824(+) TGCGGC/TTGTTC 4 Q syn1 ese37Minor allele frequency- T:0.00NS EA NA 522
    rs563302231,2,,4
    C--49856876(+) TCATGC/TAGGTT 4 Y C mis10--------
    rs1127487211,2
    C--49856909(+) CCCCAC/AGCAGT 4 /R /L mis11Minor allele frequency- A:0.50CSA 2
    rs1457802321,2
    C--49856911(+) CCAAGC/TAGTGC 4 L syn10--------
    rs1489498811,2
    C--49856932(+) TGCTCC/TACCTC 4 V syn10--------
    rs2014813911,2
    --49856934(+) CTCCAC/TCTCCC 4 M V mis10--------
    rs10626331,2,,4
    C,F,O,A,H--49856952(-) CCTTCA/GGAGTA 4 R G mis1 ese336Minor allele frequency- N:0.00MN EA NA NS WA CSA EU 9021
    rs2003413951,2
    --49856958(+) GAAGGC/TGGGTC 4 T A mis10--------
    rs50309751,2
    C,F--49856959(-) CGACCC/TACCTT 4 P syn12Minor allele frequency- T:0.01NA EU 5873
    rs1888309281,2
    --49857066(+) GCCACC/TCACTT 2 -- int10--------
    rs1510348701,2
    --49857209(+) GAGGTC/TGAACT 2 -- int10--------
    rs1812207031,2
    --49857262(+) GGGCTA/GTGTGA 2 -- int10--------
    rs1423160581,2
    C--49857297(+) CTGTGC/TCTCTG 2 -- int10--------
    rs1863529341,2
    --49857377(+) GCTCAC/TGAGGT 2 -- int10--------
    rs1469096181,2
    --49857434(+) GCAAAA/GCAGGA 2 -- int10--------
    rs126376811,2
    C,F,H--49857476(+) GCTCAT/CGCCTG 2 -- int13Minor allele frequency- C:0.38NA 8
    rs1417866131,2
    --49857499(+) TTTGGA/GAGGCT 2 -- int10--------
    rs1909465711,2
    --49857737(+) TTAGCC/TGGGCG 2 -- int10--------
    rs117143241,2
    C,A,H--49857753(+) gcaggC/Tgcctg 2 -- int10--------
    rs1828486331,2
    --49857852(+) CTCCAA/GCCTGG 2 -- int10--------
    rs350178501,2
    C--49857881(+) AAAAAA/-TTACT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1873159321,2
    --49857920(+) CACACA/GCCTGT 2 -- int10--------
    rs1380062441,2
    --49858227(+) AATTCC/TCAGAC 2 -- int10--------
    rs1157839711,2
    F--49858236(+) ACTCTC/TGGAAG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1909623011,2
    --49858253(+) CTGTTG/TTCTCC 2 -- int10--------
    rs76278641,2
    C,F,H--49858625(+) tgcccC/GCAACC 2 -- int111Minor allele frequency- G:0.26NS EA WA NA 756
    rs560570351,2
    C,F--49858769(+) CTACTC/TGCATC 2 -- int12Minor allele frequency- T:0.13WA 120
    rs1832575091,2
    C--49858820(+) TTTACC/TTATGT 2 -- int10--------
    rs1875907781,2
    --49858889(+) GTATGA/GAGCTG 2 -- int10--------
    rs1494813991,2
    C--49858906(+) AGCACC/TGAACC 2 -- int10--------
    rs1481945611,2
    C--49859327(+) GTCTCC/TGGGGC 2 -- int10--------
    rs1995401421,2
    --49859351(+) CACTAC/TCACCT 2 -- int10--------
    rs1480515121,2
    C,F--49859408(+) GCCGAC/TCCTGG 4 D G mis11Minor allele frequency- T:0.00NA 4542
    rs1452381521,2
    C--49859458(+) ATGGT-/GGGGGGC 4 P H fra10--------
    rs124893861,2
    C,F,H--49859515(+) GGAAAG/TGGGGA 2 -- int1 trp319Minor allele frequency- T:0.06NS EA NA WA EU 3663
    rs1415013121,2
    --49859647(+) TACATC/TACCTG 2 -- int10--------
    rs1919664501,2
    --49859663(+) TTCCTC/TTGTCT 2 -- int10--------
    rs782670641,2
    C,F--49859709(+) GGGCAG/AGCCCT 2 -- int11Minor allele frequency- A:0.02WA 118
    rs124958311,2
    C,F,H--49859734(+) GAGCCA/CGTGAG 2 -- int110Minor allele frequency- C:0.08NS EA NA WA 788
    rs1462783601,2
    C--49859993(+) ACAGGC/TAGGCG 4 L syn10--------
    rs2017181821,2
    --49860009(+) GGCGAC/TGCTGT 4 H R mis10--------
    rs2008177331,2
    --49860024(+) CACTAC/TAGTAC 4 Y C mis10--------
    rs1398617761,2
    F--49860033(+) ACTCCC/GTGTCC 4 T R mis11Minor allele frequency- G:0.00NA 4550
    rs559683121,2
    C,F--49860047(+) ATGTCG/ACGGGC 4 /R syn12Minor allele frequency- A:0.01WA NA 4668
    rs1407474281,2
    C--49860089(+) GACTCG/ATCCAG 4 /D syn11Minor allele frequency- A:0.00NA 4548
    rs1393962521,2
    C--49860357(+) TAGTAC/GAGACG 2 -- int10--------
    rs1827063751,2
    C--49860555(+) GCTGGA/GGTGGG 2 -- int10--------
    rs43953931,2
    C,F,A,H--49860626(-) AGAGTA/TGCTGG 2 -- int110Minor allele frequency- T:0.02NS EA NA EU 1259
    rs2015418431,2
    --49860829(+) AGAGCC/GAGATG 2 -- int10--------
    rs2011235551,2
    --49860863(+) GGATGA/GACTGG 4 S F mis10--------
    rs2004543531,2
    --49860990(+) CTCTCA/GCAGGA 4 R * stg10--------
    rs556430421,2
    C,F--49861037(+) AGCAGC/AGCAAG 2 -- int15Minor allele frequency- A:0.07NA WA EA EU 1595
    rs2006214781,2
    F--49861038(+) GCAGCG/ACAAGT 2 -- int11Minor allele frequency- A:0.00EU 1251
    rs2019592021,2
    --49861046(+) AGTCAC/GGCACA 2 -- int10--------
    rs1505621301,2
    C--49861059(+) GCAGGG/TCGTCC 2 -- int10--------
    rs738341191,2
    C--49861060(+) CAGGGC/TGTCCC 2 -- int12Minor allele frequency- T:0.13WA 120
    rs2013612061,2
    C--49861068(+) CCCTTC/TATAAG 2 -- int10--------
    rs558565441,2
    C--49861202(+) ACTTAC/TGACTT 2 -- spd10--------
    rs2005717611,2
    --49861225(+) GCACAC/TTGGAT 4 Q syn10--------
    rs1508765581,2
    C,F--49861233(+) GATTCG/AATTCT 4 /R /* stg12Minor allele frequency- A:0.00NA EU 5875
    rs1924368831,2
    C--49861318(+) AGAGGA/C/GGATCC 2 -- int10--------
    rs1995878301,2
    --49861325(+) ATCCAC/GGGCCC 2 -- int10--------
    rs2015967481,2
    --49861328(+) CAGGGC/TCCAAG 2 -- int10--------
    rs1844158291,2
    --49861622(+) GGCCAA/GGCTGG 2 -- int10--------
    rs1393293341,2
    --49861685(+) GATTAC/TAGGTG 2 -- int10--------
    rs1874857311,2
    --49861898(+) AACCCA/GGGAGG 2 -- int10--------
    rs1131639831,2
    C,F--49861973(+) ATCCCC/TCTCAA 2 -- int12Minor allele frequency- T:0.03CSA WA 119
    rs748107851,2
    C--49862098(+) GATGCA/TGTCTT 2 -- int10--------
    rs796656941,2
    C--49862100(+) TGCTGG/TCTTTT 2 -- int10--------
    rs1428424721,2
    --49862113(+) TTAAA-/TTAAAA 2 -- int10--------
    rs358719511,2
    C,F--49862189(+) GAGGTC/TAGGGG 2 -- int13Minor allele frequency- T:0.09WA CSA 122
    rs67957031,2
    C,F,A,H--49862228(+) aacccT/Cgtctc 2 -- int15Minor allele frequency- C:0.36NA CSA 14
    rs1925949111,2
    --49862256(+) TTAGAC/TAGGTG 2 -- int10--------
    rs111302231,2
    C,F,A,H--49862283(+) cccctC/Gtaatc 2 -- int13Minor allele frequency- G:0.50NA 10
    rs1845394411,2
    --49862527(+) TGAGAC/TCAGCC 2 -- int10--------
    rs1459518271,2
    C--49862727(+) CTCAA-/AAAT  
            
    AAATA
    2 -- int10--------
    rs3746038281,2
    C--49862727(+) CTCAA-/AAA   
       TAAAT
    AAATA
    2 -- int10--------
    rs1889865061,2
    --49862784(+) CTCACG/TCCTGT 2 -- int10--------
    rs1815376651,2
    --49862981(+) GGGGAA/GGTTGC 2 -- int10--------
    rs1849705761,2
    --49863064(+) AGGCCA/GGGCGC 2 -- int10--------
    rs1897508791,2
    --49863204(+) GGCACA/GGTGGC 2 -- int10--------
    rs1446012731,2
    --49863289(+) TGAGTC/TGAGAT 2 -- int10--------
    rs98159301,2
    C,H--49863352(+) aaaaaT/Aaaaat 2 -- int1 trp34Minor allele frequency- A:0.00NA CSA 7
    rs1810062851,2
    --49863589(+) GAGGAA/GGAGGT 2 -- int10--------
    rs1861372701,2
    --49863611(+) GAGATC/TGCGCC 2 -- int10--------
    rs1897279851,2
    --49863666(+) AAAAAA/TAATAA 2 -- int10--------
    rs1112261811,2
    C,F--49863769(+) GGAAGG/TTTAGG 2 -- int11Minor allele frequency- T:0.11NA 120
    rs1819302591,2
    --49863799(+) CAGGAA/GTTCGA 2 -- int10--------
    rs1863021701,2
    --49863802(+) GAGTTC/TGAGGC 2 -- int10--------
    rs1118167211,2
    C,F--49864011(+) TCACAA/GAAACA 2 -- int13Minor allele frequency- G:0.05CSA WA EA 240
    rs1418533381,2
    --49864212(+) AGAAGA/GTTAGA 2 -- int10--------
    rs2004991401,2
    --49864650(+) GCTCAG/TGGGGA 4 H P mis10--------
    rs2001232361,2
    --49864829(+) AGAGGA/GAATGA 2 -- int10--------
    rs1437861611,2
    C--49864837(+) TGAGGA/TGCTTG 2 -- int10--------
    rs1907911721,2
    --49865096(+) GTAGGG/TACTTG 2 -- int10--------
    rs1510922591,2
    --49865104(+) TTGAAG/TATGCC 2 -- int10--------
    rs2018185221,2
    --49865109(+) GATGCC/TATTGG 2 -- int10--------
    rs2015670761,2
    C--49865184(+) GTAGCC/TGAAGA 4 S G mis10--------
    rs1996185691,2
    C--49865237(+) GCAGGA/GTACCA 4 T I mis10--------
    rs1430965141,2
    C,F--49865249(+) GGAGCG/ATGCTC 4 /T /M mis12Minor allele frequency- A:0.00NA EU 5867
    rs2018363991,2
    C--49865270(+) CATCTG/AGCCCT 4 /P /L mis11Minor allele frequency- A:0.00EU 1321
    rs1999702561,2
    C--49865280(+) TGGCCG/ACACCA 4 /R /W mis11Minor allele frequency- A:0.00EU 1315
    rs130787351,2
    C,F,H--49865283(+) CCGCAC/TCACTC 4 M V mis110Minor allele frequency- T:0.01NS EA NA 848
    rs2012632421,2
    C--49865366(+) CTCTGC/TCCGTG 2 -- int10--------
    rs1495849081,2
    F--49865429(+) GCCAAG/ACTGCA 3 /L /F mis1 int11Minor allele frequency- A:0.00NA 4464
    rs560919181,2,,4
    C--49865501(+) ACCCAC/TGGTCA 3 M V mis1 int11Minor allele frequency- T:0.00NA 4550
    rs738341201,2
    C--49865625(+) CTATCC/TCTTAC 2 -- int12Minor allele frequency- T:0.13WA 120
    rs1407360521,2
    C--49865713(+) GGAAGC/TGAAAG 4 H R mis11Minor allele frequency- T:0.00NA 4552
    rs412917141,2
    C,F--49865733(+) GTAAAG/CCCAGC 4 /G syn13Minor allele frequency- C:0.00NA EU 5877
    rs1881205031,2
    --49865918(+) AGCACA/GAGGTT 2 -- int10--------
    rs2020085571,2
    --49865932(+) CTGCAA/GCTCAG 2 -- int10--------
    rs2015557331,2
    --49865975(+) GCACTC/TACTCA 2 -- int10--------
    rs1998945261,2
    C--49866068(+) GATGTA/GGGAGT 4 H Y mis10--------
    rs1114587371,2
    C,F--49866139(+) CCCCAG/AAGGCC 2 -- int12Minor allele frequency- A:0.00NA EU 709
    rs1494286331,2
    C,F--49866183(+) CACAGT/GTGGGG 4 /N /T mis11Minor allele frequency- G:0.00NA 4310
    rs1480816121,2
    C--49866202(+) TAGCAC/TGACAG 4 M V mis11Minor allele frequency- T:0.00NA 4100
    rs2002422751,2
    --49866222(+) TGTACC/TGGAAG 4 Q R mis10--------
    rs1410188371,2
    --49866556(+) GATGGA/GCTCTC 2 -- int10--------
    rs2003009381,2
    F--49866648(+) TTCCCT/GCCATC 2 -- int11Minor allele frequency- G:0.00EU 593
    rs2015647321,2
    C--49866704(+) CATGCC/ATGCCT 2 -- int11Minor allele frequency- A:0.00EU 1323
    rs2010085811,2
    C--49866723(+) TTACCA/GTGCTA 4 R W mis10--------
    rs1450622081,2
    C,F--49866781(+) GACAGA/CCTCTG 4 R S mis11Minor allele frequency- C:0.00NA 4552
    rs617343811,2
    C,F--49866837(+) GGGTTG/ACACTG 4 /Q /* stg13Minor allele frequency- A:0.00NS WA NA 4738
    rs1501200921,2
    C--49866919(+) CCGTAA/CCATGC 2 -- int10--------
    rs1997748401,2
    C--49866955(+) AGGTAC/GCCTCA 2 -- int10--------
    rs2010249561,2
    C--49866999(+) CGTCTA/CCCCGG 4 G V mis10--------
    rs3707745561,2
    C--49867116(+) CTTTCC/TGGGGC 4 Q R mis10--------
    rs98750381,2
    C,F,H--49867203(+) CACAGG/AGCTCC 2 -- int16Minor allele frequency- A:0.01NS NA 628
    rs788295821,2
    C--49867473(+) AGGGAC/GGGGAG 2 -- int10--------
    rs1479262231,2
    C,F--49867504(+) TTTGAG/CCTGTC 4 /S /R mis11Minor allele frequency- C:0.00NA 4552
    rs98198881,2
    C,F--49867512(+) GTCCTT/AGGGCA 4 /K /* stg12Minor allele frequency- A:0.01WA NA 4670
    rs359866851,2,,4
    C,F--49867535(+) GACTTT/GGGCCC 4 /Q /P mis14Minor allele frequency- G:0.01NA EU 5877
    rs562739481,2
    C--49867546(+) ACAGTA/GACCTG 4 V syn10--------
    rs2002922661,2
    C--49867559(+) GGGTTC/TCCTCA 4 E G mis11Minor allele frequency- T:0.00EU 1323
    rs1911316371,2
    C--49867650(+) GGGGTA/GGAACT 4 H Y mis10--------
    rs1463431521,2
    F--49867654(+) TGGAAC/GTGAAA 2 -- spa11Minor allele frequency- G:0.00NA 4552
    rs1505633881,2
    C,F--49867655(+) GGAACT/CGAAAT 2 -- spa11Minor allele frequency- C:0.00NA 4550
    rs1848539501,2
    --49867753(+) CCCCAC/TGCTCC 2 -- int10--------
    rs1877530801,2
    --49867754(+) CCCACA/GCTCCA 2 -- int10--------
    rs1445586041,2
    C,F--49867985(+) AGTGGT/GCCTGT 4 /D /A mis11Minor allele frequency- G:0.00NA 4550
    rs787977391,2
    C,F--49867987(+) TGGTCC/TTGTTG 4 Q syn12Minor allele frequency- T:0.00WA NA 4552
    rs1490645211,2
    C,F--49868023(+) TGGCCG/ACACAT 4 /C syn11Minor allele frequency- A:0.00NA 4550
    rs2012525841,2
    F--49868037(+) CCCACA/CCCAGC 4 G C mis11Minor allele frequency- C:0.00EU 973
    rs22305901,2,,4
    C,F,A,H--49868111(-) TATCCG/AAGGCC 4 /Q /R mis131Minor allele frequency- A:0.47MN NS EA NA WA CSA EU 8284
    rs1410979701,2
    C--49868112(+) GCCTTG/CGATAG 4 /Q /E mis11Minor allele frequency- C:0.00NA 4506
    rs2017485211,2
    --49868281(+) CCTGGC/TCCCAG 2 -- int10--------
    rs2011434361,2
    C,F--49868287(+) CCCAGG/ACCCTG 2 -- int11Minor allele frequency- A:0.02EU 1319
    rs1381836861,2
    C--49868346(+) CAAGAC/TGACTG 4 H R mis11Minor allele frequency- A:0.00NA 4552
    rs343504701,2,,4
    C--49868347(+) AAGACG/AACTGA 4 /R /C mis12Minor allele frequency- A:0.00NA 4
    rs558988101,2
    C,F--49868369(+) ACGGGC/TTGCCC 4 Q syn12Minor allele frequency- T:0.00NA EU 5875
    rs1999376701,2
    C--49868378(+) CCACTA/GTCACC 4 D syn10--------
    rs2020965971,2
    --49868410(+) CAGCAA/GGTAGT 4 L syn10--------
    rs345648981,2,,4
    C--49868542(+) TTGTGC/TCCATG 4 D G mis12Minor allele frequency- T:0.00NA 4
    rs1438168511,2
    C,F--49868571(+) TCAAGG/TCGTGT 4 R syn12Minor allele frequency- T:0.00NA EU 5875
    rs22305921,2,,4
    C,F,H--49868617(-) ATTCAA/GTGGGC 4 N S mis1 ese314Minor allele frequency- G:0.04MN NS EA NA WA 5886
    rs2007244731,2
    C--49868632(+) CCACAC/TGTGAG 4 H R mis11Minor allele frequency- T:0.00EU 1285
    rs22305911,2,,4
    C,F,H--49868635(-) CTTCTC/TACGTG 4 S L mis1 ese314Minor allele frequency- T:0.00MN NS EA NA EU 7195
    rs2010636971,2
    --49868712(+) TGGGAA/CAGGTC 2 -- int10--------
    rs412917161,2
    C,F--49868724(+) GGGAAG/AGGAAG 2 -- int15Minor allele frequency- A:0.08NA WA EA EU 909
    rs1149243541,2
    C,F--49868729(+) GGGAAG/AGAGTC 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1127548431,2
    F--49868821(+) TGACTA/GGAGAA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs111302241,2
    C,F,A,H--49868919(+) TCCACT/ACCTCA 2 -- int111Minor allele frequency- A:0.42NA WA CSA EA 376
    rs780164851,2
    F--49868997(+) CCCCGG/TACATC 2 -- int11Minor allele frequency- T:0.50NA 4
    rs1426574761,2
    --49869139(+) CTCCCA/GAGTAG 2 -- int10--------
    rs124935651,2
    C,H--49869214(+) TTTCAC/TGATGT 2 -- int10--------
    rs760976821,2
    C,F--49869482(+) GCAAAC/ACCTGT 2 -- int11Minor allele frequency- A:0.02WA 118
    rs76152061,2
    C,F,A,H--49869514(+) CCACTT/CGCATA 2 -- int121Minor allele frequency- C:0.26NS EA WA NA 2348
    rs1898455781,2
    C--49869556(+) ACAAGA/GTTGGG 2 -- int10--------
    rs746731851,2
    C,F--49869625(+) ACCCCC/GCTTCA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1486692581,2
    --49869654(+) CCAAAC/TCCCTA 2 -- int10--------
    rs1412441461,2
    --49869730(+) AGGGGG/TTGTTT 2 -- int10--------
    rs1162534111,2
    F--49869759(+) CTCCAG/AGGGAG 2 -- int11Minor allele frequency- A:0.03WA 118
    rs765025021,2
    C,F--49869921(+) CTGAAG/AGCTCC 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1814675081,2
    --49869974(+) TGATTA/TGTAGC 2 -- int10--------
    rs1169964411,2
    C,F--49870090(+) GAAATC/AGGCTT 2 -- int11Minor allele frequency- A:0.03EA 120
    rs37747581,2
    C,F,A,H--49870236(+) CTCTAC/GGTTCC 2 -- int115Minor allele frequency- G:0.47NA WA CSA EA 380
    rs1845525051,2
    --49870297(+) TCCCAC/TGGAGG 2 -- int10--------
    rs76486321,2
    C,F,A--49870401(+) CACTGC/GACGGG 2 -- int15Minor allele frequency- G:0.06NA WA CSA 126
    rs1506489791,2
    --49870403(+) CTGCAC/TGGGGT 2 -- int10--------
    rs753068521,2
    F--49870640(+) CTCAGC/AAGAGG 2 -- int11Minor allele frequency- A:0.02WA 118
    rs102224111,2
    C,H--49870643(+) AGCAGA/GGGGAG 2 -- int1 trp33Minor allele frequency- G:0.00NS NA 230
    rs1883211111,2
    --49870716(+) GGAGCA/GGAAAG 2 -- int10--------
    rs76161711,2
    C,F,A,H--49870767(+) ATGATA/TGCTAG 2 -- int116Minor allele frequency- T:0.08NS EA NA CSA WA 1642
    rs1408016521,2
    --49870860(+) AGATAC/GAGTCT 2 -- int10--------
    rs1165517281,2
    F--49870964(+) AATTCC/TAACCA 2 -- int11Minor allele frequency- T:0.01NA 120
    rs1808401001,2
    C--49871011(+) TAGTTA/GCTTGC 2 -- int10--------
    rs355357541,2
    C--49871018(+) TTGCAC/TAAGAC 2 -- int10--------
    rs37747591,2
    C,F,H--49871129(+) CCCAGG/TACATG 2 -- int120Minor allele frequency- T:0.21EA NS NA WA 3656
    rs1865855981,2
    --49871586(+) AGCTAC/TGCTAA 2 -- int10--------
    rs37331341,2
    C,F,A--49871600(+) AGACAC/TGGTTA 2 -- int111Minor allele frequency- T:0.18EA NA WA CSA 1852
    rs37331351,2
    C,F,A,H--49871684(+) AGCAAG/AATGAG 2 -- int113Minor allele frequency- A:0.22EA NA WA CSA 1843
    rs130840271,2
    C--49871771(+) ACTTAA/GGAACT 2 -- int10--------
    rs1385794381,2
    C,F--49871911(+) TTACCG/AGGTTG 4 /P /L mis11Minor allele frequency- A:0.00NA 4352
    rs2002864031,2
    C--49871946(+) AAGTCA/GAGGCC 4 L syn10--------
    rs1995310101,2
    C--49872090(+) GTCACA/TAAGAC 4 L F mis10--------
    rs2015460061,2
    --49872122(+) CTCGGC/TGATGC 4 T A mis10--------
    rs2007577761,2
    C--49872161(+) TGGAGC/TGGAGT 4 T A mis10--------
    rs22305931,2,,4
    C,F,H--49872175(-) GCTGCG/AGGTGG 4 /Q /R mis1 ese319Minor allele frequency- A:0.05MN NA EA NS EU 7603
    rs1999363161,2
    --49872178(+) CCCGCA/GGCACA 4 P L mis10--------
    rs2018056381,2
    C--49872209(+) TGGGGC/TCCCCC 4 T A mis10--------
    rs1507365421,2
    C--49872214(+) CCCCCC/TGGCGC 4 Q R mis11Minor allele frequency- G:0.00NA 4448
    rs2000460521,2
    C--49872223(+) GCCTGC/GGTTTT 4 P R mis11Minor allele frequency- G:0.00EU 897
    rs1437528521,2
    C,F--49872253(+) GGACCA/GGCTCC 4 P L mis11Minor allele frequency- G:0.00NA 4514
    rs1397535781,2
    C--49872304(+) CCAGGC/TGTGTG 4 H R mis11Minor allele frequency- T:0.00NA 4530
    rs2000382231,2
    C--49872315(+) TGCAGG/AGCACT 4 /A syn11Minor allele frequency- A:0.00EU 1135
    rs1451738271,2
    C,F--49872335(+) TGTCAC/TGCTGG 4 M V mis11Minor allele frequency- T:0.00NA 4548
    rs2002724781,2
    C--49872348(+) GGCTGT/CACAGT 4 /V syn11Minor allele frequency- C:0.00EU 1263
    rs1478761361,2
    C,F--49872366(+) TATACG/AAAGGC 4 /F syn11Minor allele frequency- A:0.01NA 4546
    rs2019101841,2
    C--49872468(+) GAGGCA/G/TTCAGC 6 E D mis1 syn11EU 1109
    rs1391572661,2
    C--49872522(+) GCCACG/AGCTGC 4 /A syn11Minor allele frequency- A:0.00NA 4402
    rs556333791,2,,4
    C--49872587(+) TACACA/GGGTGC 4 R C mis10--------
    rs133189431,2
    C,F--49872596(+) GCCCAA/GTGGGC 4 L syn1 ese34Minor allele frequency- G:0.01CSA WA NA 4598
    rs1511069601,2
    C,F--49872614(+) ACAGTC/TGGGGC 4 N D mis12Minor allele frequency- T:0.00NA EU 5701
    rs1416365131,2
    F--49872627(+) TCATCG/AGGCCG 4 /P syn11Minor allele frequency- A:0.00NA 4468
    rs2011861571,2
    --49872663(+) GCTGGC/TGCTGC 4 A syn10--------
    rs2006346481,2
    --49872704(+) GTCATA/GCAGGA 4 H Y mis10--------
    rs1500641621,2
    --49872757(+) GCAGCA/GCGGGA 4 A V mis10--------
    rs2012888661,2
    --49872827(+) GGCTGC/TACACG 4 T A mis10--------
    rs2003434871,2
    --49872831(+) GCACAC/TGTCTG 4 T syn10--------
    rs1403992311,2
    C--49872887(+) CTTCAG/CGTCAG 4 /L /V mis11Minor allele frequency- C:0.00NA 4548
    rs562049491,2
    C,F--49872909(+) TGCAGG/TCGATT 4 R syn13Minor allele frequency- T:0.01NA EU 5729
    rs358875391,2,,4
    C,F--49872917(+) ATTGCG/TTATGG 4 S R mis14Minor allele frequency- T:0.00NA EU 5711
    rs2019650591,2
    --49872955(+) CGCCCC/TCGTAG 4 E G mis10--------
    rs1443389091,2
    C--49872986(+) GCCTCC/TGGCGG 4 R G mis11Minor allele frequency- T:0.00NA 4552
    rs2009359781,2
    --49873114(+) AGGACG/TGAGGC 4 Q P mis10--------
    rs1455913341,2
    C--49873122(+) GGCAGC/TGGCGG 4 P syn11Minor allele frequency- T:0.00NA 2800
    rs352527861,2
    C--49873459(+) CGGGCC/TGTGGG 2 -- us2k10--------
    rs22804061,2
    C,F,A,H--49873533(-) CAGGCC/TTCCAA 2 -- us2k125Minor allele frequency- T:0.30EA NS NA WA CSA 3800
    rs358387361,2
    C,F,H--49873741(+) CAACAC/ACCTCA 2 -- us2k15Minor allele frequency- A:0.01NS NA 696
    rs1433295871,2
    C--49874058(+) ACCCGA/GCTAAT 2 -- us2k10--------
    rs1870528651,2
    --49874136(+) TGATCC/TGCCCG 2 -- us2k10--------
    rs1137262051,2
    C,F--49874140(+) CCGCCC/TGCCTC 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1913956481,2
    --49874305(+) GATCTC/GGCCTT 2 -- us2k10--------
    rs1833136831,2
    --49874504(+) AACATA/GCTCTG 2 -- us2k10--------
    rs1402823951,2
    --49874717(+) GTGACC/TGGGCG 2 -- us2k10--------
    rs1869871431,2
    --49875082(+) GAGTGA/GGGGTG 2 -- us2k10--------
    rs1899059101,2
    --49875138(+) AACTGA/GTCCCC 2 -- us2k10--------
    rs775679851,2
    C,F--49875297(+) GGAGAG/AAGGAG 2 -- us2k13Minor allele frequency- A:0.08WA NA EA 358
    rs1452921361,2
    --49875354(+) TCACTA/CCCCTT 2 -- us2k10--------
    rs1137979851,2
    C,F--49928352(+) GACGGG/CGTTTC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs347137861,2
    C--49930102(+) AAAAA-/AGGCTC 2 -- int10--------
    rs1118737811,2
    C--49930316(+) TGAATC/TCAGGA 2 -- int10--------
    rs1444747601,2
    C--49930714(+) CTCAA-/AAAT  
            
    AAATA
    2 -- int10--------
    rs710805581,2
    C--49930715(-) CAGCC-/TATT  
            
    TATTT
    2 -- int11Minor allele frequency- TATT:0.00NA 2
    rs98159291,2
    C--49931338(+) aaaaaA/Taaaaa 2 -- int1 trp32Minor allele frequency- T:0.25NA CSA 4
    rs96830651,2
    C--49931348(+) aaaaaA/Taaaat 2 -- int10--------
    rs729381901,2
    C,F--49942702(+) AAGACC/TAACAT 2 -- us2k13Minor allele frequency- T:0.04WA CSA 122
    rs74332311,2,4
    ----see VAR_0617492 mis40--------
    VAR_0417774
    ----see VAR_0417772 R G mis40--------
    rs1997878261,2
    ----49875148(+) CCAACA/GCTAGA 2 -- us2k10--------
    rs3690359531,2
    ----49870091(+) AAATCA/GCTTGG 2 -- int10--------
    rs3735677231,2
    ----49872296(+) AAGCCA/GTGCCA 4 R W mis10--------
    rs2015445301,2
    ----49868076(+) GCAACC/GCCCAC 4 R G mis10--------
    rs1391639941,2
    ----49866317(+) AAAAGC/GTGCCC 4 H Q mis10--------
    rs3775991151,2
    ----49867034(+) GTCACA/GGTGAG 4 T syn10--------
    rs3684467811,2
    ----49873146(+) GAGGCA/GAGCTG 2 -- ut510--------
    rs678112431,2
    ----49864787(+) GTGGT-/GGAATC 4 P T fra10--------
    rs3742643061,2
    ----49860055(+) GGCCAA/GACCAA 4 L syn10--------
    rs1402507081,2
    ----49860971(+) GGCCAC/TGCATG 4 H R mis11Minor allele frequency- T:0.00NA 4552
    rs3700344751,2
    ----49870338(+) CCTGAA/GGCCAA 2 -- int10--------
    rs666376921,2
    ----49868235(+) TGTCA-/ATGCCT 2 -- int10--------
    rs724614731,2
    ----49873886(+) GTCCT-/TTTTTT 2 -- us2k10--------
    rs710805591,2
    ----49869035(-) GTCTC-/AAA   
       AAAAA
    AAAAA
    2 -- int11Minor allele frequency- AAAAAAAA:0.00NA 2
    rs3756971461,2
    ----49865171(+) TCCTCC/TGCCAC 4 Q R mis10--------
    rs2007669231,2
    ----49865172(+) CCTCCA/GCCACC 4 R W mis10--------
    rs3729357011,2
    ----49861029(+) GCCTGC/TAGAGC 2 -- int10--------
    rs3751124441,2
    ----49860963(+) GTGGTC/TCAGGC 4 N D mis10--------
    rs3692322031,2
    ----49866786(+) ACTCTA/GGCCTT 4 Q * stg10--------
    rs3720592991,2
    ----49867523(+) GTGGCC/TGGCAG 4 Q R mis10--------
    rs3748733541,2
    ----49865670(+) TTCAGC/TGGAAC 4 P syn10--------
    rs3763170411,2
    ----49858725(+) AATAGG/TAGAGC 2 -- int10--------
    rs3693741471,2
    ----49861661(+) CACCTA/CGGCCT 2 -- int10--------
    rs3757080721,2
    ----49872344(+) GGCCGC/GCTGTA 4 P A mis10--------
    rs3719369671,2
    ----49864704(+) CCCTTA/GGCTGG 4 P L mis10--------
    rs3678619171,2
    ----49864564(+) ATGTCA/GTCTTG 2 -- int10--------
    rs356012391,2
    ----49859549(+) AAATT-/TGGGGG 2 -- int10--------
    rs3765516161,2
    ----49864728(+) GCAGCA/TGTGGC 4 Q L mis10--------
    rs561312271,2
    ----49868565(+) ACGTTA/GTCAAG 4 D syn10--------
    rs3763459791,2
    ----49864298(+) CAGGCG/TGAGTG 2 -- int10--------
    rs37331361,2
    ----49872803(+) AGGGCC/TGTGGG 4 S G mis1 ese30--------
    rs775568181,2
    ----49939385(+) GTGGGT/GGAGGG 2 -- int11Minor allele frequency- G:0.00NA 2