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MST1R Gene(Protein Coding)

Macrophage Stimulating 1 Receptor

GCID:
GC03M049924
GIFtS:
71
Genes Participants
UDN Logo

Aliases for MST1R Gene

Aliases for MST1R Gene

  • Macrophage Stimulating 1 Receptor 2 3 5
  • PTK8 Protein Tyrosine Kinase 8 2 3
  • C-Met-Related Tyrosine Kinase 2 3
  • MSP Receptor 3 4
  • EC 2.7.10.1 4 63
  • P185-Ron 3 4
  • CDw136 3 4
  • PTK8 3 4
  • RON 3 4
  • Protein-Tyrosine Kinase 8 4
  • CD136 Antigen 4
  • EC 2.7.10 63
  • CD136 3

External Ids for MST1R Gene

Previous HGNC Symbols for MST1R Gene

  • RON
  • PTK8

Previous GeneCards Identifiers for MST1R Gene

  • GC03P050091
  • GC03P050215
  • GC03M049778
  • GC03M049884
  • GC03M049885
  • GC03M049899

Summaries for MST1R Gene

Entrez Gene Summary for MST1R Gene

  • This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

GeneCards Summary for MST1R Gene

MST1R (Macrophage Stimulating 1 Receptor) is a Protein Coding gene. Diseases associated with MST1R include Renal Oncocytoma and Breast Cancer. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RYK.

UniProtKB/Swiss-Prot for MST1R Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Gene Wiki entry for MST1R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MST1R Gene

Genomics for MST1R Gene

Products:

  1. Regulatory Element

Regulatory Elements for MST1R Gene

Enhancers for MST1R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MST1R on UCSC Golden Path with GeneCards custom track

Promoters for MST1R Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MST1R on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MST1R gene promoter:

Genomic Location for MST1R Gene

Chromosome:
3
Start:
49,886,981 bp from pter
End:
49,903,873 bp from pter
Size:
16,893 bases
Orientation:
Minus strand

Genomic View for MST1R Gene

Genes around MST1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MST1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MST1R Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MST1R Gene

Proteins for MST1R Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MST1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04912-RON_HUMAN
    Recommended name:
    Macrophage-stimulating protein receptor
    Protein Accession:
    Q04912
    Secondary Accessions:
    • B5A944
    • B5A945
    • B5A946
    • B5A947

    Protein attributes for MST1R Gene

    Size:
    1400 amino acids
    Molecular mass:
    152271 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion.

    Three dimensional structures from OCA and Proteopedia for MST1R Gene

    Alternative splice isoforms for MST1R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MST1R Gene

Proteomics data for MST1R Gene at MOPED

Protein Expression for MST1R Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MST1R Gene

Q04912:

Post-translational modifications for MST1R Gene

  • Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site.
  • Proteolytic processing yields the two subunits.
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
  • Glycosylation at Asn 66, Asn 419, Asn 458, Asn 488, Asn 654, Asn 720, Asn 841, and Asn 897
  • Modification sites at PhosphoSitePlus

Other Protein References for MST1R Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MST1R Gene

Gene Families for MST1R Gene

HGNC:
IUPHAR :

Protein Domains for MST1R Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MST1R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q04912

UniProtKB/Swiss-Prot:

RON_HUMAN :
  • Contains 3 IPT/TIG domains.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • Contains 3 IPT/TIG domains.
  • Contains 1 protein kinase domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with MST1R: view

Function for MST1R Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MST1R Gene

GENATLAS Biochemistry:
macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development of epithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk) homolog,conferring susceptibility to friend virus induced erythroleukemia in mice
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Enzyme Numbers (IUBMB) for MST1R Gene

Gene Ontology (GO) - Molecular Function for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MST1R: view

Phenotypes for MST1R Gene

MGI mutant phenotypes for MST1R:
inferred from 6 alleles
GenomeRNAi human phenotypes for MST1R:
genes like me logo Genes that share phenotypes with MST1R: view

Animal Models for MST1R Gene

MGI Knock Outs for MST1R:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MST1R Gene

Localization for MST1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for MST1R Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MST1R Gene COMPARTMENTS Subcellular localization image for MST1R gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
vacuole 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
genes like me logo Genes that share ontologies with MST1R: view

Pathways & Interactions for MST1R Gene

genes like me logo Genes that share pathways with MST1R: view

SIGNOR curated interactions for MST1R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MST1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006928 movement of cell or subcellular component TAS 9045873
GO:0006952 defense response TAS 9045873
GO:0007165 signal transduction TAS 7939629
GO:0038145 macrophage colony-stimulating factor signaling pathway TAS 9045873
genes like me logo Genes that share ontologies with MST1R: view

Drugs & Compounds for MST1R Gene

Products:

  1. Drug

(8) Drugs for MST1R Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
macrophage stimulating protein 1 Pharma 0
Foretinib (GSK1363089) Pharma VEGF and HGF receptor inhibitor 0
foretinib Pharma inhibitor Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
MGCD265 Pharma Inhibition, inhibitor Kinase Inhibitors, c-MET/hepatocyte growth factor receptor (HGFR) pathway inhibitors 0

(3) Additional Compounds for MST1R Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for MST1R Gene

Compound Action Cas Number
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor 849217-64-7
genes like me logo Genes that share compounds with MST1R: view

Transcripts for MST1R Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MST1R Gene

(11) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MST1R Gene

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MST1R Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MST1R Gene

GeneLoc Exon Structure for
MST1R
ECgene alternative splicing isoforms for
MST1R

Expression for MST1R Gene

Products:

  1. Primer

mRNA expression in normal human tissues for MST1R Gene

mRNA expression in normal human tissues for MST1R Gene
mRNA expression by BioGPS for MST1R GenemRNA expression by GTEx for MST1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MST1R Gene

This gene is overexpressed in Colon - Transverse (x7.7), Stomach (x6.1), Skin - Sun Exposed (Lower leg) (x5.4), and Skin - Not Sun Exposed (Suprapubic) (x5.3).

Protein differential expression in normal tissues from HIPED for MST1R Gene

This gene is overexpressed in Stomach (40.3) and Heart (24.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MST1R Gene



SOURCE GeneReport for Unigene cluster for MST1R Gene Hs.517973

mRNA Expression by UniProt/SwissProt for MST1R Gene

Q04912-RON_HUMAN
Tissue specificity: Expressed in colon, skin, lung and bone marrow.
genes like me logo Genes that share expression patterns with MST1R: view

Protein tissue co-expression partners for MST1R Gene

- Elite partner

Primer Products

Orthologs for MST1R Gene

This gene was present in the common ancestor of animals.

Orthologs for MST1R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia MST1R 35
  • 82.68 (n)
  • 81.25 (a)
MST1R 36
  • 80 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia MST1R 35
  • 82.54 (n)
  • 80.63 (a)
MST1R 36
  • 80 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mst1r 35
  • 78.74 (n)
  • 76.39 (a)
Mst1r 16
Mst1r 36
  • 75 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia MST1R 35
  • 99.55 (n)
  • 99.5 (a)
MST1R 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Mst1r 35
  • 78.29 (n)
  • 76.65 (a)
oppossum
(Monodelphis domestica)
 Mammalia MST1R 36
  • 53 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MST1R 36
  • 50 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MST1R 35
  • 58.92 (n)
  • 49.28 (a)
MST1R 36
  • 46 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MST1R 36
  • 39 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100496572 35
  • 52.33 (n)
  • 45.94 (a)
zebrafish
(Danio rerio)
 Actinopterygii mst1rb 35
  • 49.59 (n)
  • 43.24 (a)
mst1ra 36
  • 39 (a)
 OneToMany
mst1rb 36
  • 41 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta hop 37
  • 37 (a)
worm
(Caenorhabditis elegans)
 Secernentea F09A5.2 37
  • 33 (a)
F11E6.8 37
  • 49 (a)
kin-16 37
  • 31 (a)
kin-23 37
  • 33 (a)
old-1 37
  • 30 (a)
old-2 37
  • 32 (a)
T14E8.1a 37
  • 36 (a)
T14E8.1b 37
  • 40 (a)
W04G5.10 37
  • 34 (a)
svh-2 36
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 44 (a)
 OneToMany
Species with no ortholog for MST1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MST1R Gene

ENSEMBL:
Gene Tree for MST1R (if available)
TreeFam:
Gene Tree for MST1R (if available)

Paralogs for MST1R Gene

Paralogs for MST1R Gene

(80) SIMAP similar genes for MST1R Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MST1R: view

Variants for MST1R Gene

Sequence variations from dbSNP and Humsavar for MST1R Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_006350 -
rs1062633 - 49,887,507(-) CCTTC(A/G)GAGTA nc-transcript-variant, reference, missense
VAR_029238 -
VAR_029239 -
VAR_041768 -

Structural Variations from Database of Genomic Variants (DGV) for MST1R Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876766 CNV Loss 21882294
nsv876767 CNV Loss 21882294

Variation tolerance for MST1R Gene

Residual Variation Intolerance Score: 4.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MST1R Gene

Human Gene Mutation Database (HGMD)
MST1R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MST1R Gene

Disorders for MST1R Gene

MalaCards: The human disease database

(2) MalaCards diseases for MST1R Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal oncocytoma
  • oncocytoma of kidney
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search MST1R in MalaCards View complete list of genes associated with diseases

Relevant External Links for MST1R

Genetic Association Database (GAD)
MST1R
Human Genome Epidemiology (HuGE) Navigator
MST1R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MST1R
genes like me logo Genes that share disorders with MST1R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MST1R Gene

Publications for MST1R Gene

  1. A novel putative receptor protein tyrosine kinase of the met family. (PMID: 8386824) Ronsin C. … Breathnach R. (Oncogene 1993) 2 3 4 23 67
  2. The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells. (PMID: 19838218) Thobe M.N. … Waltz S.E. (Oncogene 2010) 3 23
  3. Knockdown of Ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma. (PMID: 19224914) Wang J. … Brattain M.G. (J. Biol. Chem. 2009) 3 23
  4. Recepteur d'origine nantais tyrosine kinase is a direct target of hypoxia-inducible factor-1alpha-mediated invasion of breast carcinoma cells. (PMID: 19307182) Thangasamy A. … Ammanamanchi S. (J. Biol. Chem. 2009) 3 23
  5. Regulation of RON tyrosine kinase-mediated invasion of breast cancer cells. (PMID: 18165235) Thangasamy A. … Ammanamanchi S. (J. Biol. Chem. 2008) 3 23

Products for MST1R Gene

  • Addgene plasmids for MST1R

Sources for MST1R Gene

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