MST1R Gene
protein-coding GIFtS: 64
GCID: GC03M049924
|
|
macrophage stimulating 1 receptor (c-met-related tyrosine...(Previous name: PTK8 protein tyrosine kinase 8 )
(Previous symbols: RON, PTK8)
| |
Aliases
for MST1R gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine Kinase)1 2 | | MST1R Variant RON302 | | RON1 2 3 5 | | MST1R Variant RON622 | | CDw1361 2 3 | | RON Variant 212 | | PTK81 2 3 | | RON Variant E2E32 | | CD1361 2 | | Soluble RON Variant 12 | | PTK8 Protein Tyrosine Kinase 81 2 | | Soluble RON Variant 22 | | MSP Receptor2 3 | | Soluble RON Variant 32 | | P185-Ron1 | | Soluble RON Variant 42 | | EC 2.7.10.13 8 | | CD136 Antigen3 | | C-Met-Related Tyrosine Kinase2 | | Protein-Tyrosine Kinase 83 | | Macrophage-Stimulating Protein Receptor2 | | EC 2.7.108 |
Export aliases for MST1R gene to outside databasesPrevious GC identifers: GC03P050091 GC03P050215 GC03M049778 GC03M049884 GC03M049885 GC03M049899 |
Summaries
for MST1R gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MST1R:
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. Themature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolyticcleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP.This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and togetherwith MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding differentisoforms with different structural and biochemical properties have been described (PMID:8816464). (provided by RefSeq,Oct 2011)
UniProtKB/Swiss-Prot: RON_HUMAN, Q04912Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by bindingto MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligandbinding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sitesfor downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1,PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of severalsignaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healingresponse by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also arole in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively,RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1ligand
Gene Wiki entry for MST1R
|
Genomic Views
for MST1R gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MST1R gene promoter:
E2F E2F-1 STAT3 E2F-2 STAT5A NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MST1R
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST1R |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21MST1R Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M049924: view genomic region
(about GC identifiers)
Start:
|
49,924,435 bp from pter |
End:
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49,941,306 bp from pter |
Size:
|
16,872 bases |
Orientation:
|
minus strand |
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Proteins
for MST1R gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 (See
protein sequence)Recommended Name: Macrophage-stimulating protein receptor precursor Size: 1400 amino acids; 152271 Da
Subunit: Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with andis negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1,GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from  and Proteopedia  for MST1R:3PLS (3D)
4FWW (3D)
Secondary accessions: B5A944 B5A945 B5A946 B5A947Alternative splicing: 6 isoforms: Q04912-1 Q04912-2 Q04912-3 Q04912-4 Q04912-5 Q04912-6 (Lacks part of the extracellular domain, oligomerizes and is constitutively activated)Explore the universe of human proteins at neXtProt for MST1R: NX_Q04912
Post-translational modifications:
Proteolytic processing yields the two subunits1
Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to furtherphosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site1
Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q04912
4/9 DME Specific Peptides for MST1R (Q04912) (see all 9)
MST1R Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001231866.1 NP_002438.2
ENSEMBL proteins: ENSP00000296474 ENSP00000408047 ENSP00000407926 ENSP00000341325 ENSP00000393294 ENSP00000414792
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MST1R for ontologies About GeneDecksing
MST1R Antibody Products:
Assay Products for MST1R: |
Protein
Domains /
Families
for MST1R gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MST1R for domains About GeneDecksing
5/14 InterPro domains/families (see all 14):Graphical View of Domain Structure for InterPro Entry Q04912ProtoNet protein and cluster: Q04912 2 Blocks protein families: IPB002909 Cell surface receptor IPT/TIG IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: RON_HUMAN, Q04912Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase familySimilarity: Contains 3 IPT/TIG domainsSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 Sema domain |
Function
for MST1R gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RON_HUMAN, Q04912Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by bindingto MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligandbinding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sitesfor downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1,PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of severalsignaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healingresponse by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also arole in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively,RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1ligandCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits thekinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing thekinase activity Genatlas biochemistry entry for MST1R:macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development ofepithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk)homolog,conferring susceptibility to friend virus induced erythroleukemia in mice
Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MST1R (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MST1R (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MST1R (NM_002447) | |  | Sino Biological Human cDNA Clone for MST1R | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MST1R | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MST1R for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for MST1R:
Animal Models:
Mouse knock-outs for MST1R: Mst1rtm1Sjd Mst1rtm1.1Sew
5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Mst1r):
MST1R for phenotypes About GeneDecksing
|
Pathways & Interactions
for MST1R gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | GPCR Pathway | | | 2 | Rho Family GTPases | | | 3 | Nanog in Mammalian ESC Pluripotency | | | 4 | Actin Nucleation by ARP-WASP Complex | | | 5 | Akt Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MST1R (see all 30)
2 
Cell Signaling Technology (CST) Pathways for MST1R
3  BioSystems Pathways for MST1R
MST1R for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MST1R
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/39 Interacting proteins for MST1R (Q049121, 2, 3 ENSP000002964744) via UniProtKB, MINT, STRING, and/or I2D (see all 39)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PLXNB1 | O431571, 3, ENSP000002964404 | EBI-2637518,EBI-1111488 I2D:
score=1 STRING: ENSP00000296440 | | PLXNB3 | Q9ULL41, 3, ENSP000003553784 | EBI-2637518,EBI-311073 I2D:
score=1 STRING: ENSP00000355378 | | CBL | P226812, 3, ENSP000002640334 | MINT-6539679 I2D:
score=2 STRING: ENSP00000264033 | | YWHAZ | P631042, 3, ENSP000003095034 | MINT-8006508 I2D:
score=2 STRING: ENSP00000309503 | | YWHAQ | P273482, 3, ENSP000002380814 | MINT-8006465 I2D:
score=2 STRING: ENSP00000238081 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
MST1R for ontologies About GeneDecksing
|
Drugs & Compounds
for MST1R gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MST1R for compounds About GeneDecksing
 Browse Tocris compounds for MST1R
2 HMDB Compounds for MST1R About this table
5 Novoseek chemical compound relationships for MST1R gene About this table
Search CenterWatch for drugs/clinical trials and news about MST1R / RON
|
Transcripts
for MST1R gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MST1R gene (2 alternative transcripts): NM_001244937.1 NM_002447.2 Unigene Cluster for MST1R: Macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Hs.517973 [show with all ESTs]Unigene Representative Sequence: NM_00244713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296474 ENST00000424150(uc011bdd.2) ENST00000411578(uc003cxy.4 uc011bdc.2 uc011bde.1 uc011bdf.1 uc011bdg.2)
ENST00000344206 ENST00000434765 ENST00000440292 ENST00000463789 ENST00000490053
ENST00000467110 ENST00000468525 ENST00000493535 ENST00000485044 ENST00000497001
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MST1R (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MST1R (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MST1R (NM_002447) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MST1R | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R |
Additional cDNA sequence: AK303234.1 EU826582.1 EU826583.1 EU826584.1 EU826585.1 HQ908652.1 JN983806.1 X70040.1 7 DOTS entries: DT.211894 DT.120879705 DT.91904328 DT.100754685 DT.92417911 DT.96086513 DT.97837134 24/72 AceView cDNA sequences (see all 72): BU542597 BG823879 BX505902 BX280864 AI659677 AW179110 AI679494 BM047000 BQ936677 BG289902 BF094070 AI651503 AA173453 BM790561 AI813693 CA503122 BM795098 BQ919273 AW604980 BM044054 AI554236 BM045664 AI675684 BM048043
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MST1R About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for MST1R
|
Expression
for MST1R gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MST1R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTATGGA
About this image
See MST1R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MST1R
SOURCE GeneReport for Unigene cluster: Hs.517973
UniProtKB/Swiss-Prot: RON_HUMAN, Q04912Tissue specificity: Expressed in colon, skin, lung and bone marrow
SABiosciences Expression via Pathway-Focused PCR Array including MST1R: | Epithelial to Mesenchymal Transition (EMT) in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MST1R
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MST1R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MST1R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1R | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R |
Orthologs
for MST1R gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MST1R gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MST1R1 |
macrophage stimulating 1 receptor (c-met-related tyrosine more |
59.24(n)
49.47(a) |
|
427573 NM_001031463.1 NP_001026634.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MST1R6 |
-- |
38(a) |
1 ↔ 1 |
2(147878310-147953639) |
African clawed frog
(Xenopus laevis) |
Amphibia |
D87758.12 |
-- |
75.07(n) |
|
D87758.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mst1rb1 |
macrophage stimulating 1 receptor (c-met-related tyrosine more |
49.87(n)
43.38(a) |
|
100134855 XM_002663812.1 XP_002663858.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F11E6.83 |
Eukaryotic protein kinase domain |
49(a)
(best of 9) |
|
IV(17444692-17450635) -- |
ENSEMBL Gene Tree for MST1R (if available)
TreeFam Gene Tree for MST1R (if available) |
Paralogs
for MST1R gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MST1R gene
- AXL2 TIE12 MET2 RYK2 TEK2 TYRO32 MERTK2
18/47 SIMAP similar genes for MST1R using alignment to 5 protein entries: RON_HUMAN J3KQS8_HUMAN J3KQS7_HUMAN (see all proteins)
(see all similar genes)(see first protein):FLT4 EPHA2 BTK kinase deficient isoform 6 ABL1 tec SRC
FLT1 CSK EZR-ROS1 FES BLK HCK
FGR RYK BTK kinase deficient isoform 2 DKFZp434L0319 EPHA3 EPHA6
MST1R for paralogs About GeneDecksing
|
Genomic Variants
for MST1R gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MST1R (49924435 - 49941306 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MST1R: --
Human Gene Mutation Database (HGMD): MST1R
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MST1R |
|
Disorders
/ Diseases
for MST1R gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MST1R for disorders About GeneDecksing
OMIM gene information: 600168
OMIM disorders: --
20/32  diseases for MST1R (see all 32): About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas renal oncocytoma benign tumors
multiple sclerosis ulcerative colitis bronchiectasis gallbladder cancer
rheumatoid arthritis endometriosis pancreatic cancer breast carcinoma
crohn's disease carcinoma breast cancer colon carcinoma
hepatocellular carcinoma ovarian carcinoma pancreatitis arthritis
10/18 Novoseek disease relationships for MST1R gene (see all 18) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| metastasis |
44.6 |
22 |
15735014 (3), 15827676 (2), 17178895 (2), 18620091 (2) (see all 12) |
| breast carcinoma |
41.6 |
5 |
9671413 (2), 11896610 (1), 18593918 (1), 15788670 (1) |
| tumors |
38.6 |
40 |
15827676 (4), 19452510 (3), 17661719 (2), 11593422 (2) (see all 22) |
| cancer |
35.9 |
39 |
16982759 (5), 17955509 (4), 17889431 (4), 18620091 (3) (see all 13) |
| pancreatic cancer |
31 |
9 |
17311308 (6), 17616662 (2) |
| lung tumor |
28.2 |
2 |
15827676 (1), 9533936 (1) |
| breast cancer |
27.5 |
21 |
19307182 (4), 15788670 (4), 18593918 (3), 17178895 (2) (see all 9) |
| carcinoma |
24.9 |
13 |
12766581 (2), 9533936 (2), 18593918 (1), 11082293 (1) (see all 6) |
| colon cancer |
16.9 |
1 |
15378025 (1), 19224914 (1) |
| mammary tumor |
16.8 |
3 |
15735014 (3) |
Human Genome Epidemiology (HuGE) Navigator: MST1R (8 documents)
Export disorders for MST1R gene to outside databases
|
Publications
for MST1R gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MST1R gene, integrated from 9 sources (see all 169):
(articles sorted by number of sources associating them with MST1R) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel putative receptor protein tyrosine kinase of the met family. (PubMed id 8386824)1, 2, 3, 9 Ronsin C.... Breathnach R. (1993)
- c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. (PubMed id 12802274)1, 2, 9 Penengo L....Gaudino G. (2003)
- RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. (PubMed id 8062829)1, 2, 9 Gaudino G....Comoglio P.M. (1994)
- Identification of the ron gene product as the receptor for the human macrophage stimulating protein. (PubMed id 7939629)1, 2, 9 Wang M.-H.... Breatnach R. (1994)
- Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)1, 2, 9 Conrotto P.... Giordano S. (2004)
- Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. (PubMed id 22848655)1, 2 Chao K.L.... Herzberg O. (2012)
- The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells. (PubMed id 18836480)1, 2 Feres K.J....Hayman M.J. (2009)
- Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)1, 2 Jin P.... Paleolog E.M. (2008)
- Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. (PubMed id 12676986)1, 2 Danilkovitch-Miagkova A.... Lerman M.I. (2003)
- A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. (PubMed id 8816464)1, 2 Collesi C.... Comoglio P.M. (1996)
|
External Searches for MST1R gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MST1R gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing MST1R gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MST1R gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MST1R gene:
Search GeneIP for patents involving MST1R
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MST1R gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | OriGene Antibodies for MST1R | | OriGene shRNA RFP for MST1R | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MST1R | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MST1R | | | OriGene Protein Over-expression Lysate for MST1R | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MST1R | | OriGene 3'-UTR Clone for MST1R | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MST1R | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MST1R | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for MST1R |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R |
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| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R |
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