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MST1R Gene

protein-coding   GIFtS: 68
GCID: GC03M049924

Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine...

(Previous name: PTK8 protein tyrosine kinase 8)
(Previous symbols: RON, PTK8)
  See related diseases
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Aliases
for MST1R gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine Kinase)1 2     MST1R Variant RON302
RON1 2 3 5     MST1R Variant RON622
PTK81 2 3     RON Variant 212
PTK8 Protein Tyrosine Kinase 81 2     RON Variant E2E32
CDw1362 3     Soluble RON Variant 12
MSP Receptor2 3     Soluble RON Variant 22
p185-Ron2 3     Soluble RON Variant 32
EC 2.7.10.13 8     Soluble RON Variant 42
CD1362     CD136 Antigen3
C-Met-Related Tyrosine Kinase2     Protein-Tyrosine Kinase 83
Macrophage-Stimulating Protein Receptor2     EC 2.7.108

External Ids:    HGNC: 73811   Entrez Gene: 44862   Ensembl: ENSG000001640787   OMIM: 6001685   UniProtKB: Q049123   

Export aliases for MST1R gene to outside databases

Previous GC identifers: GC03P050091 GC03P050215 GC03M049778 GC03M049884 GC03M049885 GC03M049899


Summaries
for MST1R gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MST1R Gene:
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity.
The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by
proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon
stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of
the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript
variants encoding different isoforms with different structural and biochemical properties have been described
(PMID:8816464). (provided by RefSeq, Oct 2011)

GeneCards Summary for MST1R Gene:
MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)) is a protein-coding gene. Diseases associated with MST1R include renal oncocytoma, and ductal carcinoma in situ. GO annotations related to this gene include macrophage colony-stimulating factor receptor activity and enzyme binding. An important paralog of this gene is AXL.

UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and
differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular
domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts
with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON
leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON
signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as
survival at the wound site. Plays also a role in the innate immune response by regulating the migration and
phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and
proliferation in response to growth factors other than MST1 ligand

Gene Wiki entry for MST1R Gene


Genomic Views
for MST1R gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MST1R gene promoter:
         E2F   E2F-1   STAT3   E2F-2   STAT5A   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MST1R promoter sequence
   Search Chromatin IP Primers for MST1R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MST1R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

MST1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1R gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049924:  view genomic region     (about GC identifiers)

Start:
 49,924,435 bp from pter      End:
 49,941,306 bp from pter
Size:
 16,872 bases      Orientation:
 minus strand

Proteins
for MST1R gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 (See protein sequence)
Recommended Name: Macrophage-stimulating protein receptor precursor  
Size: 1400 amino acids; 152271 Da
Subunit: Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with
and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1,
PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion
2 PDB 3D structures from and Proteopedia for MST1R:
3PLS (3D)        4FWW (3D)    
Secondary accessions: B5A944 B5A945 B5A946 B5A947
Alternative splicing: 6 isoforms:  Q04912-1   Q04912-2   Q04912-3   Q04912-4   Q04912-5   Q04912-6   (Lacks part of the extracellular domain, oligomerizes and is constitutively activated)

Explore the universe of human proteins at neXtProt for MST1R: NX_Q04912

Explore proteomics data for MST1R at MOPED

Post-translational modifications: 

  • Proteolytic processing yields the two subunits1
  • Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further
    phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site1
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation1
  • Glycosylation2 at Asn66, Asn419, Asn458, Asn488, Asn654, Asn720, Asn841, Asn897
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for MST1R (Q04912) (see all 9)
     FVHRDLA  QVARGME  QPEYCPD  RDLAARN 


    See MST1R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231866.1  NP_002438.2  

    ENSEMBL proteins: 
     ENSP00000296474   ENSP00000407926   ENSP00000341325   ENSP00000393294   ENSP00000414792  

    MST1R Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MST1R Protein
    R&D Systems Recombinant & Natural Proteins for MST1R (MSP R/Ron)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MST1R
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MST1R
    GenScript Custom Purified and Recombinant Proteins Services for MST1R
    Novus Biologicals MST1R Protein
    Novus Biologicals MST1R Lysate
    Sino Biological Recombinant Protein for MST1R
    Sino Biological Cell Lysate for MST1R
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MST1R

    MST1R Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MST1R (MSP R/Ron)
    Cell Signaling Technology (CST) Antibodies for MST1R  (Ron)
    OriGene Antibodies for MST1R
    OriGene Custom Antibody Services for MST1R
    Novus Biologicals MST1R Antibodies
    Abcam antibodies for MST1R
    Cloud-Clone Corp. Antibodies for MST1R
    ThermoFisher Antibodies for MST1R
    LSBio Antibodies in human, mouse, rat for MST1R

    MST1R Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MST1R
    R&D Systems ELISAs for MST1R (MSP R/Ron)         (see all)
    GenScript Custom Assay Services for MST1R
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MST1R (Ron)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MST1R
    Cloud-Clone Corp. CLIAs for MST1R

    Domains /
    Families
    for MST1R gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
    Met family
    HGF (hepatocyte growth factor) receptor family

    Selected InterPro protein domains (see all 13):
     IPR017441 Protein_kinase_ATP_BS
     IPR014756 Ig_E-set
     IPR002909 IPT
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q04912

    ProtoNet protein and cluster: Q04912

    2 Blocks protein domains:
    IPB002909 Cell surface receptor IPT/TIG
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 3 IPT/TIG domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Sema domain


    MST1R for domains           About GeneDecksing


    Function
    for MST1R gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RON_HUMAN, Q04912
    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
    binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and
    differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular
    domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts
    with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON
    leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON
    signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as
    survival at the wound site. Plays also a role in the innate immune response by regulating the migration and
    phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and
    proliferation in response to growth factors other than MST1 ligand
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the
    kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus
    increasing the kinase activity

         Genatlas biochemistry entry for MST1R:
    macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development of
    epithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk)
    homolog,conferring susceptibility to friend virus induced erythroleukemia in mice

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0004872receptor activity ----
    GO:0005011macrophage colony-stimulating factor receptor activity TAS9045873
         
    MST1R for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MST1R:
     Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mst1r):
     endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging  reproductive system 

    MST1R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MST1R: Mst1rtm1Sjd Mst1rtm1.1Sew

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MST1R
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MST1R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MST1R
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MST1R

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat MST1R using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MST1R
    SwitchGear 3'UTR luciferase reporter plasmid: MST1R 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for MST1R
    Predesigned siRNA for gene silencing in human, mouse, rat MST1R

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MST1R

    Clone
    Products:             		 OriGene clones in human, mouse for MST1R (see all 8)
    OriGene ORF clones in mouse, rat for MST1R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MST1R (NM_002447)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1R
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MST1R 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R


    Localization
    for MST1R gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RON_HUMAN, Q04912: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS7939629
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    MST1R for ontologies           About GeneDecksing


    Pathways & Interactions
    for MST1R gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MST1R About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    		Ras Pathway0.73
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.73
    		NFAT in Immune Response0.58
    		GPCR Pathway0.62
    		Estrogen Pathway0.55
    		Pancreatic Adenocarcinoma0.59
    		P2Y Receptor Signaling0.38
    2ERK Signaling
    		Rho Family GTPases0.61
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    		ILK Signaling0.49
    		MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency0.61
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation and Branching0.66
    		CDC42 Pathway0.41
    		Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA0.77
    		Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MST1R (see all 30)
        MAPK Signaling
    MSP-RON Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for MST1R
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 BioSystems Pathways for MST1R
        Alpha6-Beta4 Integrin Signaling Pathway
    a6b1 and a6b4 Integrin signaling
    amb2 Integrin signaling




    MST1R for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MST1R: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MST1R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MST1R (Q049121, 2, 3 ENSP000002964744) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNB1O431571, 3, ENSP000002964404EBI-2637518,EBI-1111488 I2D: score=1 STRING: ENSP00000296440
    PLXNB3Q9ULL41, 3, ENSP000003553784EBI-2637518,EBI-311073 I2D: score=1 STRING: ENSP00000355378
    CBLP226812, 3, ENSP000002640334MINT-6539679 I2D: score=2 STRING: ENSP00000264033
    YWHAZP631042, 3, ENSP000003095034MINT-8006508 I2D: score=2 STRING: ENSP00000309503
    YWHAQP273482, 3, ENSP000002380814MINT-8006465 I2D: score=2 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006928cellular component movement TAS9045873
    GO:0006952defense response TAS9045873
    GO:0007165signal transduction TAS7939629
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--

    MST1R for ontologies           About GeneDecksing



    Drugs & Compounds
    for MST1R gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MST1R (RON)

    2 HMDB Compounds for MST1R    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 IUPHAR Ligand for MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase))    About this table
    LigandTypeActionAffinityPubmed IDs
    macrophage stimulating protein 1
    		NoneNone--

    5 Novoseek inferred chemical compound relationships for MST1R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 76.6 79 18593918 (4), 19307182 (3), 15827676 (2), 11332718 (2) (see all 47)
    wortmannin 48.9 2 9794431 (1), 14505491 (1)
    pd 98,059 17.1 1 15001985 (1)
    phosphatidylinositol 11.8 3 19224914 (1)
    serine 11.3 1 14505491 (1)



    MST1R for compounds           About GeneDecksing



    Transcripts
    for MST1R gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for MST1R gene (2 alternative transcripts): 
    NM_001244937.1  NM_002447.2  

    Unigene Cluster for MST1R:

    Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
    Hs.517973  [show with all ESTs]
    Unigene Representative Sequence: NM_002447
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296474 ENST00000411578(uc003cxy.4 uc011bdc.2 uc011bde.1 uc011bdf.1 uc011bdg.2)
    ENST00000344206 ENST00000434765 ENST00000440292 ENST00000463789 ENST00000490053
    ENST00000467110 ENST00000468525 ENST00000493535 ENST00000485044 ENST00000497001

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate MST1R
    SwitchGear 3'UTR luciferase reporter plasmid: MST1R 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MST1R
    Clone
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    OriGene ORF clones in mouse, rat for MST1R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MST1R (NM_002447)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1R
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MST1R
      QuantiTect SYBR Green Assays in human, mouse, rat MST1R
      QuantiFast Probe-based Assays in human, mouse, rat MST1R

    Additional mRNA sequence: 

    AK303234.1 EU826582.1 EU826583.1 EU826584.1 EU826585.1 HQ908652.1 JN983806.1 X70040.1 

    7 DOTS entries:

    DT.211894  DT.120879705  DT.91904328  DT.100754685  DT.92417911  DT.96086513  DT.97837134 

    Selected AceView cDNA sequences (see all 72):

    AW179110 BX505902 AI659677 BG823879 BU542597 BX280864 AI679494 BG289902 
    BU541700 AW604980 BM048043 BM790561 BU500594 BQ919273 AI651503 BX479000 
    BM044732 BM047000 BQ900191 NM_002447 BF094070 BM795098 BM044054 X70040 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MST1R    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                    -                       -     -           -                                             
    SP2:                                                                    -     -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                             
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MST1R

    Expression
    for MST1R gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MST1R expression in normal human tissues (normalized intensities)      MST1R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATGGA
    MST1R Expression
    About this image


    MST1R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Bone (Muscoskeletal System)
             Endochondral Facial Bones
     
     Colon (Gastrointestinal Tract)
     
     Stomach (Gastrointestinal Tract)
     
     Prostate (Endocrine System)
    MST1R Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    MST1R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517973

    UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
    Tissue specificity: Expressed in colon, skin, lung and bone marrow

        Pathway & Disease-focused RT2 Profiler PCR Array including MST1R: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    Orthologs
    for MST1R gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for MST1R gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mst1r1 , 5 macrophage stimulating 1 receptor (c-met-related tyrosine more1, 5 78.74(n)1
    76.39(a)1    		   9 (59.07 cM)5
    198821  NM_009074.21  NP_033100.21 
     1079068895 
    chicken
    (Gallus gallus)    		 Aves MST1R1 macrophage stimulating 1 receptor (c-met-related tyrosine more 58.92(n)
    49.28(a)    		   427573  NM_001031463.1  NP_001026634.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MST1R6
    		 macrophage stimulating 1 receptor (c-met-related t...
    		 39(a)
    		 1 ↔ 1
    		 2(147875611-147953639)
    African clawed frog
    (Xenopus laevis)    		 Amphibia D87758.12   -- 75.07(n)    D87758.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mst1rb1 macrophage stimulating 1 receptor (c-met-related tyrosine more 49.59(n)
    43.24(a)    		   100134855  XM_002663812.2  XP_002663858.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F11E6.83 Eukaryotic protein kinase domain 49(a)
    (best of 9)    		   IV(17444692-17450635)   --


    ENSEMBL Gene Tree for MST1R (if available)
    TreeFam Gene Tree for MST1R (if available)

    Paralogs
    for MST1R gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MST1R gene
    AXL2  MET2  RYK2  TYRO32  MERTK2  
    Selected SIMAP similar genes for MST1R using alignment to 4 protein entries:     RON_HUMAN     J3KQS7_HUMAN     H7C3Z8_HUMAN (see all proteins) (see all similar genes)(see first protein):
    RON    FLT4    EPHA2    FLT1    BTK kinase deficient isoform 6    ABL1
    tec    SRC    AXL    CSK    EZR-ROS1    LRIG3(NM_001136051)-ROS1
    LRIG3(NM_153377)-ROS1    R32    R34    SLC34A2-ROS1    TPM3-ROS1    FES

    MST1R for paralogs           About GeneDecksing



    Genomic Variants
    for MST1R gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MST1R (see all 571)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1816546901,2
    		--49855997(+) TATGCC/TCCAGA 2 -- ds50010--------
    rs738341181,2
    		C,F--49856090(+) GGGAAA/CGGGGA 2 -- ds50012Minor allele frequency- C:0.13WA 120
    rs1434942441,2
    		--49856321(+) CACTGG/TTTCTG 2 -- ds50010--------
    rs1462590721,2
    		--49856339(+) TTCCCC/TGGTTG 2 -- ds50010--------
    rs76152401,2
    		C,F,H--49856340(+) tccccG/Agttga 2 -- ds50015Minor allele frequency- A:0.02NS EA 540
    rs1393280941,2
    		--49856434(+) TCACAC/TTGTTT 2 -- ds50010--------
    rs117131931,2
    		C,F,A,H--49856436(+) ACACTG/ATTTGC 2 -- ds500128Minor allele frequency- A:0.38NS EA NA WA CSA 2627
    rs1440796611,2
    		C--49856462(+) AATAGG/TCATTT 2 -- ut310--------
    rs793280511,2
    		C,F--49856497(+) GTGTTG/TGTGTG 2 -- ut311Minor allele frequency- T:0.04EA 120
    rs1482584531,2
    		C--49856763(+) GGGCCG/AAGGAG 4 /R /W mis11Minor allele frequency- A:0.00NA 4548

    HapMap Linkage Disequilibrium report for MST1R (49924435 - 49941306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MST1R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876767CNV Loss21882294
    nsv876766CNV Loss21882294
    nsv834688CNV Loss17160897

    Human Gene Mutation Database (HGMD): MST1R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MST1R
    DNA2.0 Custom Variant and Variant Library Synthesis for MST1R

    Disorders / Diseases
    for MST1R gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 600168    OMIM disorders: --

    Selected diseases for MST1R (see all 42):    About MalaCards
    renal oncocytoma    ductal carcinoma in situ    renal dysplasia    gallbladder cancer
    bronchiectasis    pancreatic cancer    endometriosis    diffuse large b-cell lymphoma
    merkel cell carcinoma    b-cell lymphomas    thyroid cancer    lung cancer
    ulcerative colitis    peritonitis    crohn's disease    inflammatory bowel disease
    ovarian cancer    osteosarcoma    multiple sclerosis    pancreatitis


    MST1R for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MST1R gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 44.6 22 15735014 (3), 15827676 (2), 17178895 (2), 18620091 (2) (see all 12)
    breast carcinoma 41.6 5 9671413 (2), 11896610 (1), 18593918 (1), 15788670 (1)
    tumors 38.6 40 15827676 (4), 19452510 (3), 17661719 (2), 11593422 (2) (see all 22)
    cancer 35.9 39 16982759 (5), 17955509 (4), 17889431 (4), 18620091 (3) (see all 13)
    pancreatic cancer 31 9 17311308 (6), 17616662 (2)
    lung tumor 28.2 2 15827676 (1), 9533936 (1)
    breast cancer 27.5 21 19307182 (4), 15788670 (4), 18593918 (3), 17178895 (2) (see all 9)
    carcinoma 24.9 13 12766581 (2), 9533936 (2), 18593918 (1), 11082293 (1) (see all 6)
    colon cancer 16.9 1 15378025 (1), 19224914 (1)
    mammary tumor 16.8 3 15735014 (3)

    Genetic Association Database (GAD): MST1R
    Human Genome Epidemiology (HuGE) Navigator: MST1R (8 documents)

    Export disorders for MST1R gene to outside databases

    Publications
    for MST1R gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MST1R gene, integrated from 10 sources (see all 183):
    (articles sorted by number of sources associating them with MST1R)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel putative receptor protein tyrosine kinase of the met family. (PubMed id 8386824)1, 2, 3, 9 Ronsin C.... Breathnach R. (Oncogene 1993)
    2. c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. (PubMed id 12802274)1, 2, 9 Penengo L.... Gaudino G. (Oncogene 2003)
    3. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. (PubMed id 8062829)1, 2, 9 Gaudino G.... Comoglio P.M. (EMBO J. 1994)
    4. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. (PubMed id 7939629)1, 2, 9 Wang M.-H.... Breatnach R. (Science 1994)
    5. Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)1, 2, 9 Conrotto P.... Giordano S. (Oncogene 2004)
    6. Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. (PubMed id 22848655)1, 2 Chao K.L.... Herzberg O. (PLoS ONE 2012)
    7. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility. (PubMed id 19657358)1, 4 MA!rquez A....Urcelay E. (Genes Immun. 2009)

    External Searches for MST1R gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MST1R gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4486 HGNC: 7381 AceView: MST1R Ensembl:ENSG00000164078 euGenes: HUgn4486
    ECgene: MST1R H-InvDB: MST1R

    Other Databases showing MST1R gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing MST1R gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MST1R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MST1R Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MST1R gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for MST1R gene:
    Search GeneIP for patents involving MST1R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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