MST1R Gene protein-coding GIFtS : 68 GCID: GC03 M049924
Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine... PTK8 protein tyrosine kinase 8 )RON, PTK8 )
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Aliasesfor MST1R gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine Kinase) 1 2 MST1R Variant RON302 RON1 2 3 5 MST1R Variant RON622 PTK81 2 3 RON Variant 212 PTK8 Protein Tyrosine Kinase 81 2 RON Variant E2E32 CDw1362 3 Soluble RON Variant 12 MSP Receptor2 3 Soluble RON Variant 22 p185-Ron2 3 Soluble RON Variant 32 EC 2.7.10.13 8 Soluble RON Variant 42 CD1362 CD136 Antigen3 C-Met-Related Tyrosine Kinase2 Protein-Tyrosine Kinase 83 Macrophage-Stimulating Protein Receptor2 EC 2.7.108
Export aliases for MST1R gene to outside databases Previous GC identifers: GC03P050091 GC03P050215 GC03M049778 GC03M049884 GC03M049885 GC03M049899
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Summariesfor MST1R gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MST1R Gene: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity.The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated byproteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation uponstimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus ofthe lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcriptvariants encoding different isoforms with different structural and biochemical properties have been described(PMID:8816464). (provided by RefSeq, Oct 2011) GeneCards Summary for MST1R Gene: MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)) is a protein-coding gene. Diseases associated with MST1R include renal oncocytoma benign tumors related super-pathways are Ras Pathway and MAPK Signaling . GO annotations related to this gene include macrophage colony-stimulating factor receptor activity and enzyme binding . An important paralog of this gene is AXL . UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 Function : Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm bybinding to MST1 ligand. Regulates many physiological processes including cell survival, migration anddifferentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellulardomain that provides docking sites for downstream signaling molecules. Following activation by ligand, interactswith the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RONleads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RONsignaling activates the wound healing response by promoting epithelial cell migration, proliferation as well assurvival at the wound site. Plays also a role in the innate immune response by regulating the migration andphagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration andproliferation in response to growth factors other than MST1 ligand Gene Wiki entry for MST1R Gene
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Genomic Viewsfor MST1R gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NT_022517.18 NC_018914.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MST1R gene promoter:E2F E2F-1 STAT3 E2F-2 STAT5A NF-kappaB NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for MST1R Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21 MST1R Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M049924: view genomic region
(about GC identifiers )
Start: 49,924,435 bp from pter End:
49,941,306 bp from pter
Size: 16,872 bases Orientation:
minus strand
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Proteinsfor MST1R gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 See
protein sequence )Recommended Name: Size : 1400 amino acids; 152271 DaSubunit : Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates withand is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1,PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion
Subcellular location : Membrane; Single-pass type I membrane protein2 PDB 3D structures from :3PLS (3D) 4FWW (3D) Secondary accessions : B5A944 B5A945 B5A946 B5A947Alternative splicing : 6 isoforms : Q04912-1 Q04912-2 Q04912-3 Q04912-4 Q04912-5 Q04912-6 (Lacks part of the extracellular domain, oligomerizes and is constitutively activated)Explore the universe of human proteins at neXtProt for MST1R: NX_Q04912 Explore proteomics data for MST1R at MOPED Post-translational modifications:
UniProtKB: Proteolytic processing yields the two subunits UniProtKB: Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to furtherphosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site UniProtKB: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q04912 4/9 DME Specific Peptides for MST1R (Q04912 ) (see all 9 )MST1R Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (2 alternative transcripts): NP_001231866.1 NP_002438.2 ENSEMBL proteins: ENSP00000296474 ENSP00000407926 ENSP00000341325 ENSP00000393294 ENSP00000414792 Human Recombinant Protein Products for MST1R: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing MST1R Antibody Products: Assay Products for MST1R:
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Protein
Domains /for MST1R gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: CD: CD molecules IUPHAR Guide to PHARMACOLOGY protein family classification: macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Met family HGF (hepatocyte growth factor) receptor family 5/14 InterPro protein domains (see all 14 ):
Graphical View of Domain Structure for InterPro Entry Q04912 ProtoNet protein and cluster: Q04912
2 Blocks protein domains : IPB002909 IPB008266 UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase familySimilarity : Contains 3 IPT/TIG domainsSimilarity : Contains 1 protein kinase domainSimilarity : Contains 1 Sema domainAbout GeneDecksing
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Functionfor MST1R gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: RON_HUMAN, Q04912 Function : Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm bybinding to MST1 ligand. Regulates many physiological processes including cell survival, migration anddifferentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellulardomain that provides docking sites for downstream signaling molecules. Following activation by ligand, interactswith the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RONleads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RONsignaling activates the wound healing response by promoting epithelial cell migration, proliferation as well assurvival at the wound site. Plays also a role in the innate immune response by regulating the migration andphagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration andproliferation in response to growth factors other than MST1 ligand Catalytic activity : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation : In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits thekinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thusincreasing the kinase activity
Genatlas biochemistry entry for MST1R macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development ofepithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk)homolog,conferring susceptibility to friend virus induced erythroleukemia in mice Enzyme Numbers (IUBMB): EC 2.7.10.1 1 2 EC 2.7.10 2 Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004672 protein kinase activity
-- -- GO:0004713 protein tyrosine kinase activity
-- -- GO:0004714 transmembrane receptor protein tyrosine kinase activity
-- -- GO:0004872 receptor activity
-- -- GO:0005011 macrophage colony-stimulating factor receptor activity
TAS 9045873
About GeneDecksing Phenotypes: 4 GenomeRNAi human phenotypes for MST1R :5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mst1r) :About GeneDecksing Animal Models: MGI mouse knock-outs for MST1R: Mst1r tm1Sjd Mst1r tm1.1Sew Cell Line GenScript Custom overexpressing Cell Line Services for MST1R Search LifeMap BioReagents cell lines for MST1R In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R
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Pathways & Interactionsfor MST1R gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for MST1R About (see all 16 ) See pathways by source SuperPath Contained pathways About 1 GPCR Pathway 2 Rho Family GTPases 3 Nanog in Mammalian ESC Pluripotency 4 Actin Nucleation by ARP-WASP Complex 5 Activation of cAMP-Dependent PKA
Pathways by source See SuperPaths Show all pathways 5/30 (see all 30 )2 3 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MST1R STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/39 Interacting proteins for MST1R (Q04912 1 , 2 , 3 ENSP00000296474 4 via UniProtKB, MINT, STRING , and/or I2D (see all 39 )Interactant Interaction Details GeneCard External ID(s) PLXNB1 O43157 1 , 3 ENSP00000296440 4 EBI-2637518,EBI-1111488 I2D:
score=1 STRING: ENSP00000296440 PLXNB3 Q9ULL4 1 , 3 ENSP00000355378 4 EBI-2637518,EBI-311073 I2D:
score=1 STRING: ENSP00000355378 CBL P22681 2 , 3 ENSP00000264033 4 MINT-6539679 I2D:
score=2 STRING: ENSP00000264033 YWHAZ P63104 2 , 3 ENSP00000309503 4 MINT-8006508 I2D:
score=2 STRING: ENSP00000309503 YWHAQ P27348 2 , 3 ENSP00000238081 4 MINT-8006465 I2D:
score=2 STRING: ENSP00000238081
About this table Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13 ): About this table
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Drugs & Compoundsfor MST1R gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for MST1R (RON) 2 HMDB Compounds for MST1R About this table 1 IUPHAR Ligand for MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)) About this table 5 Novoseek inferred chemical compound relationships for MST1R gene About this table MST1R / RON
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Transcriptsfor MST1R gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MST1R gene (2 alternative transcripts): NM_001244937.1 NM_002447.2 Unigene Cluster for MST1R:
Macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Hs.517973 [show with all ESTs ] Unigene Representative Sequence: NM_002447 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000296474 ENST00000411578 (uc003cxy.4 uc011bdc.2 uc011bde.1 uc011bdf.1 uc011bdg.2 )ENST00000344206 ENST00000434765 ENST00000440292 ENST00000463789 ENST00000490053 ENST00000467110 ENST00000468525 ENST00000493535 ENST00000485044 ENST00000497001 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AK303234.1 EU826582.1 EU826583.1 EU826584.1 EU826585.1 HQ908652.1 JN983806.1 X70040.1
7 DOTS entries : DT.211894 DT.120879705
DT.91904328 DT.100754685 DT.92417911 DT.96086513 DT.97837134 24/72 AceView cDNA sequences (see all 72 ):
BG823879 BX505902 AW179110 BU542597 AI659677 BX280864 BM044732 BM790561 BM048043 BM795098 BX479000 AA173453 BM796337 BG289902 BM047000 BQ919273 BQ900191 BU541700 BM044054 CA503122 AI651503 BF094070 AI675684 BU500594 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for MST1R About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ SP1 : - - - - SP2 : - - SP3 : SP4 : - SP5 :
ExUns: 20 SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for MST1R
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Expression for MST1R gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MST1R expression in normal human tissues
(normalized intensities) MST1R embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: TATTTATGGAAbout this image
MST1R expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/6 selected tissues (see all 6 ) fully expand See MST1R Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MST1R SOURCE GeneReport for Unigene cluster: Hs.517973 UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 Tissue specificity : Expressed in colon, skin, lung and bone marrowSABiosciences Expression via Pathway-Focused PCR Array including MST1R : Epithelial to Mesenchymal Transition (EMT) in human mouse rat
Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R
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Orthologsfor MST1R gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for MST1R gene from 6/15 species (see all 15 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Mst1r1 5
macrophage stimulating 1 receptor (c-met-related tyrosine more 1, 5
78.34(n) 1 76.1(a) 1
9 (59.07 cM) 5 19882 1 NM_009074.2 1 NP_033100.2 1 107906889 5
chicken Aves MST1R1
macrophage stimulating 1 receptor (c-met-related tyrosine more
59.24(n) 49.47(a)
427573 NM_001031463.1 NP_001026634.1
lizard Reptilia MST1R6
Uncharacterized protein
38(a)
1 ↔ 1
2(147875611-147953639)
African clawed frog Amphibia D87758.12
--
75.07(n)
D87758.1
zebrafish Actinopterygii mst1rb1
macrophage stimulating 1 receptor (c-met-related tyrosine more
49.87(n) 43.38(a)
100134855 XM_002663812.1 XP_002663858.1
worm Secernentea F11E6.83
Eukaryotic protein kinase domain
49(a)
IV(17444692-17450635) --
ENSEMBL Gene Tree for MST1R (if available)TreeFam Gene Tree for MST1R (if available)
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Paralogsfor MST1R gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MST1R gene AXL 2 MET 2 RYK 2 TYRO3 2 MERTK 2 18/71 SIMAP similar genes for MST1R using alignment to 4 protein entries: RON_HUMAN J3KQS7_HUMAN H7C3Z8_HUMAN (see all proteins )
(see all similar genes )(see
first protein RON FLT4 EPHA2 BTK kinase deficient isoform 6 ABL1 tec SRC AXL FLT1 CSK EZR-ROS1 LRIG3(NM_001136051)-ROS1 LRIG3(NM_153377)-ROS1 R32 R34 SLC34A2-ROS1 TPM3-ROS1 FES About GeneDecksing
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Genomic Variantsfor MST1R gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 3 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for MST1R (49924435 - 49941306 bp)
Structural Variations Database of Genomic Variants (DGV) 3 variations for MST1R : About this table Human Gene Mutation Database (HGMD) : MST1R SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing MST1R
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Disorders
/ Diseasesfor MST1R gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 600168
OMIM disorders : --20/35 (see all 35 ): About MalaCards renal oncocytoma benign tumors renal dysplasia gallbladder cancer bronchiectasis endometriosis pancreatic cancer diffuse large b-cell lymphoma ductal carcinoma in situ b-cell lymphomas thyroid cancer ulcerative colitis peritonitis crohn's disease multiple sclerosis osteosarcoma pancreatitis gastric cancer inflammatory bowel disease hypoxia About GeneDecksing 10/18 Novoseek inferred disease relationships for MST1R gene (see all 18 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis
44.6
22
15735014 (3), 15827676 (2), 17178895 (2), 18620091 (2) (see
all 12 )
breast carcinoma
41.6
5
9671413 (2), 11896610 (1), 18593918 (1), 15788670 (1)
tumors
38.6
40
15827676 (4), 19452510 (3), 17661719 (2), 11593422 (2) (see
all 22 )
cancer
35.9
39
16982759 (5), 17955509 (4), 17889431 (4), 18620091 (3) (see
all 13 )
pancreatic cancer
31
9
17311308 (6), 17616662 (2)
lung tumor
28.2
2
15827676 (1), 9533936 (1)
breast cancer
27.5
21
19307182 (4), 15788670 (4), 18593918 (3), 17178895 (2) (see
all 9 )
carcinoma
24.9
13
12766581 (2), 9533936 (2), 18593918 (1), 11082293 (1) (see
all 6 )
colon cancer
16.9
1
15378025 (1), 19224914 (1)
mammary tumor
16.8
3
15735014 (3)
Genetic Association Database (GAD): MST1R Human Genome Epidemiology (HuGE) Navigator: MST1R (8 documents) Export disorders for MST1R gene to outside databases
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Publicationsfor MST1R gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MST1R gene, integrated from 9 sources (see all 177 ):(articles sorted by number of sources associating them with MST1R) Utopia : connect your pdf to the dynamic
A novel putative receptor protein tyrosine kinase of the met family. (PubMed id 8386824) 1 , 2 , 3, 9(1993) c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. (PubMed id 12802274) 1 , 2 , 9(2003) RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. (PubMed id 8062829) 1 , 2 , 9(1994) Identification of the ron gene product as the receptor for the human macrophage stimulating protein. (PubMed id 7939629) 1 , 2 , 9(1994) Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888) 1 , 2 , 9(2004) Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. (PubMed id 22848655) 1 , 2 (2012) Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603) 1 , 4(2010) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 , 4(2010) Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581) 1 , 4(2009) Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility. (PubMed id 19657358) 1 , 4(2009)
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ECgene ,
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ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MST1R gene: MST1R GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MST1R gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MST1R QIAGEN SeqTarget long-range PCR primers for resequencing MST1R QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for MST1R (Ron)
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R
ThermoFisher Antibodies for MST1R
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R
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