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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MST1R Gene

protein-coding   GIFtS: 68
GCID: GC03M049924

Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine...

(Previous name: PTK8 protein tyrosine kinase 8)
(Previous symbols: RON, PTK8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine Kinase)1 2     MST1R Variant RON302
RON1 2 3 5     MST1R Variant RON622
PTK81 2 3     RON Variant 212
PTK8 Protein Tyrosine Kinase 81 2     RON Variant E2E32
CDw1362 3     Soluble RON Variant 12
MSP Receptor2 3     Soluble RON Variant 22
p185-Ron2 3     Soluble RON Variant 32
EC 2.7.10.13 8     Soluble RON Variant 42
CD1362     CD136 Antigen3
C-Met-Related Tyrosine Kinase2     Protein-Tyrosine Kinase 83
Macrophage-Stimulating Protein Receptor2     EC 2.7.108

External Ids:    HGNC: 73811   Entrez Gene: 44862   Ensembl: ENSG000001640787   OMIM: 6001685   UniProtKB: Q049123   

Export aliases for MST1R gene to outside databases

Previous GC identifers: GC03P050091 GC03P050215 GC03M049778 GC03M049884 GC03M049885 GC03M049899


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MST1R Gene:
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity.
The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by
proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon
stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of
the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript
variants encoding different isoforms with different structural and biochemical properties have been described
(PMID:8816464). (provided by RefSeq, Oct 2011)

GeneCards Summary for MST1R Gene: 
MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)) is a protein-coding gene. Diseases associated with MST1R include renal oncocytoma, and benign tumors, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include macrophage colony-stimulating factor receptor activity and enzyme binding. An important paralog of this gene is AXL.

UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and
differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular
domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts
with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON
leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON
signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as
survival at the wound site. Plays also a role in the innate immune response by regulating the migration and
phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and
proliferation in response to growth factors other than MST1 ligand

Gene Wiki entry for MST1R Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MST1R gene promoter:
         E2F   E2F-1   STAT3   E2F-2   STAT5A   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMST1R promoter sequence
   Search SABiosciences Chromatin IP Primers for MST1R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST1R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

MST1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1R gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049924:  view genomic region     (about GC identifiers)

Start:
49,924,435 bp from pter      End:
49,941,306 bp from pter
Size:
16,872 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 (See protein sequence)
Recommended Name: Macrophage-stimulating protein receptor precursor  
Size: 1400 amino acids; 152271 Da
Subunit: Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with
and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1,
PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for MST1R:
3PLS (3D)        4FWW (3D)    
Secondary accessions: B5A944 B5A945 B5A946 B5A947
Alternative splicing: 6 isoforms:  Q04912-1   Q04912-2   Q04912-3   Q04912-4   Q04912-5   Q04912-6   (Lacks part of the extracellular domain, oligomerizes and is constitutively activated)

Explore the universe of human proteins at neXtProt for MST1R: NX_Q04912

Explore proteomics data for MST1R at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytic processing yields the two subunits
  • UniProtKB: Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further
    phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site
  • UniProtKB: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04912

  • 4/9 DME Specific Peptides for MST1R (Q04912) (see all 9)
     FVHRDLA  QVARGME  QPEYCPD  RDLAARN 

    MST1R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MST1R Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231866.1  NP_002438.2  

    ENSEMBL proteins: 
     ENSP00000296474   ENSP00000407926   ENSP00000341325   ENSP00000393294   ENSP00000414792  

    Human Recombinant Protein Products for MST1R: 
    EMD Millipore Purified and/or Recombinant MST1R Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MST1R
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MST1R
    GenScript Custom Purified and Recombinant Proteins Services for MST1R
    Novus Biologicals MST1R Protein
    Novus Biologicals MST1R Lysate
    Sino Biological Recombinant Protein for MST1R
    Sino Biological Cell Lysate for MST1R 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MST1R 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS7939629
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    MST1R for ontologies           About GeneDecksing



    MST1R Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MST1R (MSP R/Ron)
    Cell Signaling Technology (CST) Antibodies for MST1R  (Ron)
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    GenScript Custom Superior Antibodies Services for MST1R
    Novus Biologicals MST1R Antibodies
    Abcam antibodies for MST1R
    Cloud-Clone Corp. Antibodies for MST1R 
    ThermoFisher Antibodies for MST1R
    LSBio Antibodies in human, mouse, rat for MST1R 

    Assay Products for MST1R: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for MST1R (MSP R/Ron)         (see all)
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for MST1R (Ron)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MST1R 
    Cloud-Clone Corp. CLIAs for MST1R


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: macrophage stimulating 1 receptor (c-met-related tyrosine kinase) 
    Met family
    HGF (hepatocyte growth factor) receptor family

    5/14 InterPro protein domains (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR014756 Ig_E-set
     IPR002909 IPT_TIG_rcpt
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q04912

    ProtoNet protein and cluster: Q04912

    2 Blocks protein domains:
    IPB002909 Cell surface receptor IPT/TIG
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 3 IPT/TIG domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Sema domain


    MST1R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RON_HUMAN, Q04912
    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
    binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and
    differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular
    domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts
    with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON
    leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON
    signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as
    survival at the wound site. Plays also a role in the innate immune response by regulating the migration and
    phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and
    proliferation in response to growth factors other than MST1 ligand
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the
    kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus
    increasing the kinase activity

         Genatlas biochemistry entry for MST1R:
    macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development of
    epithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk)
    homolog,conferring susceptibility to friend virus induced erythroleukemia in mice

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0004872receptor activity ----
    GO:0005011macrophage colony-stimulating factor receptor activity TAS9045873
         
    MST1R for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MST1R:
     Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mst1r):
     endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging  reproductive system 

    MST1R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MST1R: Mst1rtm1Sjd Mst1rtm1.1Sew

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MST1R 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MST1R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MST1R 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MST1R 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MST1R
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MST1R
    SwitchGear 3'UTR luciferase reporter plasmidMST1R 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MST1R (NM_002447)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1R
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                         Customized lentivirus expression plasmids for stable overexpression of MST1R 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MST1R About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MST1R (see all 30)
        MAPK Signaling
    MSP-RON Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for MST1R
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 BioSystems Pathways for MST1R
        Alpha6-Beta4 Integrin Signaling Pathway
    a6b1 and a6b4 Integrin signaling
    amb2 Integrin signaling




    MST1R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MST1R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for MST1R (Q049121, 2, 3 ENSP000002964744) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNB1O431571, 3, ENSP000002964404EBI-2637518,EBI-1111488 I2D: score=1 STRING: ENSP00000296440
    PLXNB3Q9ULL41, 3, ENSP000003553784EBI-2637518,EBI-311073 I2D: score=1 STRING: ENSP00000355378
    CBLP226812, 3, ENSP000002640334MINT-6539679 I2D: score=2 STRING: ENSP00000264033
    YWHAZP631042, 3, ENSP000003095034MINT-8006508 I2D: score=2 STRING: ENSP00000309503
    YWHAQP273482, 3, ENSP000002380814MINT-8006465 I2D: score=2 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006928cellular component movement TAS9045873
    GO:0006952defense response TAS9045873
    GO:0007165signal transduction TAS7939629
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--

    MST1R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MST1R for compounds           About GeneDecksing

    EMD Millipore small molecules for MST1R:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MST1R (RON)

    2 HMDB Compounds for MST1R    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 IUPHAR Ligand for MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase))    About this table 
    LigandTypeActionAffinityPubmed IDs
    macrophage stimulating protein 1
    NoneNone--

    5 Novoseek inferred chemical compound relationships for MST1R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 76.6 79 18593918 (4), 19307182 (3), 15827676 (2), 11332718 (2) (see all 47)
    wortmannin 48.9 2 9794431 (1), 14505491 (1)
    pd 98,059 17.1 1 15001985 (1)
    phosphatidylinositol 11.8 3 19224914 (1)
    serine 11.3 1 14505491 (1)

    Search CenterWatch for drugs/clinical trials and news about MST1R / RON

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MST1R gene (2 alternative transcripts): 
    NM_001244937.1  NM_002447.2  

    Unigene Cluster for MST1R:

    Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
    Hs.517973  [show with all ESTs]
    Unigene Representative Sequence: NM_002447
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296474 ENST00000411578(uc003cxy.4 uc011bdc.2 uc011bde.1 uc011bdf.1 uc011bdg.2)
    ENST00000344206 ENST00000434765 ENST00000440292 ENST00000463789 ENST00000490053
    ENST00000467110 ENST00000468525 ENST00000493535 ENST00000485044 ENST00000497001

    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1R
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R
    Sirion Biotech Customized lentivirus for stable overexpression of MST1R 
                         Customized lentivirus expression plasmids for stable overexpression of MST1R 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1R

    Additional mRNA sequence: 

    AK303234.1 EU826582.1 EU826583.1 EU826584.1 EU826585.1 HQ908652.1 JN983806.1 X70040.1 

    7 DOTS entries:

    DT.211894  DT.120879705  DT.91904328  DT.100754685  DT.92417911  DT.96086513  DT.97837134 

    24/72 AceView cDNA sequences (see all 72):

    BG823879 BX505902 AW179110 BU542597 AI659677 BX280864 BM044732 BM790561 
    BM048043 BM795098 BX479000 AA173453 BM796337 BG289902 BM047000 BQ919273 
    BQ900191 BU541700 BM044054 CA503122 AI651503 BF094070 AI675684 BU500594 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MST1R    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                    -                       -     -           -                                             
    SP2:                                                                    -     -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                             
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MST1R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MST1R expression in normal human tissues (normalized intensities)      MST1R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATGGA
    MST1R Expression
    About this image


    MST1R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colonic mucosal (ibs)   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Bone (Muscoskeletal System)
             Endochondral Facial Bones
     
     Stomach (Gastrointestinal Tract)

    See MST1R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MST1R

    SOURCE GeneReport for Unigene cluster: Hs.517973

    UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
    Tissue specificity: Expressed in colon, skin, lung and bone marrow

        SABiosciences Expression via Pathway-Focused PCR Array including MST1R: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MST1R
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MST1R
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MST1R
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1R
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MST1R gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mst1r1 , 5 macrophage stimulating 1 receptor (c-met-related tyrosine more1, 5 78.34(n)1
    76.1(a)1
      9 (59.07 cM)5
    198821  NM_009074.21  NP_033100.21 
     1079068895 
    chicken
    (Gallus gallus)
    Aves MST1R1 macrophage stimulating 1 receptor (c-met-related tyrosine more 59.24(n)
    49.47(a)
      427573  NM_001031463.1  NP_001026634.1 
    lizard
    (Anolis carolinensis)
    Reptilia MST1R6
    Uncharacterized protein
    38(a)
    1 ↔ 1
    2(147875611-147953639)
    African clawed frog
    (Xenopus laevis)
    Amphibia D87758.12   -- 75.07(n)    D87758.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mst1rb1 macrophage stimulating 1 receptor (c-met-related tyrosine more 49.87(n)
    43.38(a)
      100134855  XM_002663812.1  XP_002663858.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F11E6.83 Eukaryotic protein kinase domain 49(a)
    (best of 9)
      IV(17444692-17450635)   --


    ENSEMBL Gene Tree for MST1R (if available)
    TreeFam Gene Tree for MST1R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MST1R gene
    AXL2  MET2  RYK2  TYRO32  MERTK2  
    18/71 SIMAP similar genes for MST1R using alignment to 4 protein entries:     RON_HUMAN (see all proteins) (see all similar genes):
    RON    FLT4    EPHA2    BTK kinase deficient isoform 6    ABL1    tec
    SRC    AXL    FLT1    CSK    EZR-ROS1    LRIG3(NM_001136051)-ROS1
    LRIG3(NM_153377)-ROS1    R32    R34    SLC34A2-ROS1    TPM3-ROS1    FES

    MST1R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/571 SNPs in MST1R are shown (see all 571)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0617494
    ----see VAR_0617492 S G mis40--------
    VAR_0417774
    ----see VAR_0417772 R G mis40--------
    rs1816546901,2
    --49855997(+) TATGCC/TCCAGA 2 -- ds50010--------
    rs738341181,2
    C,F--49856090(+) GGGAAA/CGGGGA 2 -- ds50012Minor allele frequency- C:0.13WA 120
    rs1434942441,2
    --49856321(+) CACTGG/TTTCTG 2 -- ds50010--------
    rs1462590721,2
    --49856339(+) TTCCCC/TGGTTG 2 -- ds50010--------
    rs76152401,2
    C,F,H--49856340(+) tccccG/Agttga 2 -- ds50015Minor allele frequency- A:0.02NS EA 540
    rs1393280941,2
    --49856434(+) TCACAC/TTGTTT 2 -- ds50010--------
    rs117131931,2
    C,F,A,H--49856436(+) ACACTG/ATTTGC 2 -- ds500128Minor allele frequency- A:0.38NS EA NA WA CSA 2627
    rs1440796611,2
    C--49856462(+) AATAGG/TCATTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MST1R (49924435 - 49941306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MST1R:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876767CNV Loss21882294
    nsv876766CNV Loss21882294
    nsv834688CNV Loss17160897


    Human Gene Mutation Database (HGMD): MST1R
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MST1R
    DNA2.0 Custom Variant and Variant Library Synthesis for MST1R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600168    OMIM disorders: --

    20/35 diseases for MST1R (see all 35):    About MalaCards
    renal oncocytoma    benign tumors    renal dysplasia    gallbladder cancer
    bronchiectasis    endometriosis    pancreatic cancer    diffuse large b-cell lymphoma
    ductal carcinoma in situ    b-cell lymphomas    thyroid cancer    ulcerative colitis
    peritonitis    crohn's disease    multiple sclerosis    osteosarcoma
    pancreatitis    gastric cancer    inflammatory bowel disease    hypoxia


    MST1R for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for MST1R gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 44.6 22 15735014 (3), 15827676 (2), 17178895 (2), 18620091 (2) (see all 12)
    breast carcinoma 41.6 5 9671413 (2), 11896610 (1), 18593918 (1), 15788670 (1)
    tumors 38.6 40 15827676 (4), 19452510 (3), 17661719 (2), 11593422 (2) (see all 22)
    cancer 35.9 39 16982759 (5), 17955509 (4), 17889431 (4), 18620091 (3) (see all 13)
    pancreatic cancer 31 9 17311308 (6), 17616662 (2)
    lung tumor 28.2 2 15827676 (1), 9533936 (1)
    breast cancer 27.5 21 19307182 (4), 15788670 (4), 18593918 (3), 17178895 (2) (see all 9)
    carcinoma 24.9 13 12766581 (2), 9533936 (2), 18593918 (1), 11082293 (1) (see all 6)
    colon cancer 16.9 1 15378025 (1), 19224914 (1)
    mammary tumor 16.8 3 15735014 (3)

    Genetic Association Database (GAD): MST1R
    Human Genome Epidemiology (HuGE) Navigator: MST1R (8 documents)

    Export disorders for MST1R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MST1R gene, integrated from 9 sources (see all 177) (see top 10):
    (articles sorted by number of sources associating them with MST1R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel putative receptor protein tyrosine kinase of the met family. (PubMed id 8386824)1, 2, 3, 9 Ronsin C.... Breathnach R. (1993)
    2. c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. (PubMed id 12802274)1, 2, 9 Penengo L....Gaudino G. (2003)
    3. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. (PubMed id 8062829)1, 2, 9 Gaudino G....Comoglio P.M. (1994)
    4. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. (PubMed id 7939629)1, 2, 9 Wang M.-H.... Breatnach R. (1994)
    5. Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)1, 2, 9 Conrotto P.... Giordano S. (2004)
    6. Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. (PubMed id 22848655)1, 2 Chao K.L.... Herzberg O. (2012)
    7. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    10. Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility. (PubMed id 19657358)1, 4 MA!rquez A....Urcelay E. (2009)
    11. The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells. (PubMed id 18836480)1, 2 Feres K.J....Hayman M.J. (2009)
    12. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)1, 2 Jin P.... Paleolog E.M. (2008)
    13. Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. (PubMed id 12676986)1, 2 Danilkovitch-Miagkova A.... Lerman M.I. (2003)
    14. A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. (PubMed id 8816464)1, 2 Collesi C.... Comoglio P.M. (1996)
    15. Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells. (PubMed id 18593918)1, 9 Narasimhan M. and Ammanamanchi S. (2008)
    16. Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target. (PubMed id 17311308)1, 9 Camp E.R....Ellis L.M. (2007)
    17. Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells. (PubMed id 18310076)1, 9 Zhao S....Freeman J.W. (2008)
    18. Met-related receptor tyrosine kinase Ron in tumor growth and metastasis. (PubMed id 18620091)1, 9 Wagh P.K....Waltz S.E. (2008)
    19. Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. (PubMed id 16740632)1, 9 Germano S....Gaudino G. (2006)
    20. Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients. (PubMed id 15788670)1, 9 Lee W.Y....Guo H.R. (2005)
    21. Recepteur d'Origine Nantais Tyrosine Kinase Is a Direct Target of Hypoxia-inducible Factor-1{alpha}-mediated Invasion of Breast Carcinoma Cells. (PubMed id 19307182)1, 9 Thangasamy A....Ammanamanchi S. (2009)
    22. Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor. (PubMed id 14505491)1, 9 Santoro M.M....Villa-Moruzzi E. (2003)
    23. Regulation of RON tyrosine kinase-mediated invasion of breast cancer cells. (PubMed id 18165235)1, 9 Thangasamy A....Ammanamanchi S. (2008)
    24. Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence. (PubMed id 17588532)1, 9 Cote M....Liu S.L. (2007)
    25. The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells. (PubMed id 19838218)1, 9 Thobe M.N....Waltz S.E. (2010)
    26. The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness. (PubMed id 12915129)1, 9 Maggiora P....Flavia Di Renzo M. (2003)
    27. Knockdown of ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma. (PubMed id 19224914)1, 9 Wang J....Brattain M.G. (2009)
    28. Prognostic value of MET, RON and histoprognostic factors for urothelial carcinoma in the upper urinary tract. (PubMed id 18221954)1, 9 Comperat E....Cussenot O. (2008)
    29. Collaborative activities of macrophage-stimulating protein and transforming growth factor-beta1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase. (PubMed id 15001985)1, 9 Wang D....Wang M.H. (2004)
    30. The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma. (PubMed id 12766581)1, 9 Rampino T....Dal Canton A. (2003)
    31. Cross-talk between the proto-oncogenes Met and Ron. (PubMed id 10871856)1, 9 Follenzi A....Comoglio P.M. (2000)
    32. RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells. (PubMed id 15378025)1, 9 Xu X.M....Wang M.H. (2004)
    33. Proteolytic cleavage and activation of pro-macrophage-stimulating protein and upregulation of its receptor in tissue injury. (PubMed id 9764835)2, 9 Nanney L.B....Leonard E.J. (1998)
    34. The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression. (PubMed id 17616662)1, 9 Thomas R.M....Lowy A.M. (2007)
    35. RON-regulated innate immunity is protective in an animal model of multiple sclerosis. (PubMed id 15929040)1, 9 Tsutsui S....Power C. (2005)
    36. Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. (PubMed id 9045873)1, 9 Sakamoto O....Suda T. (1997)
    37. The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. (PubMed id 12919677)1, 9 Santoro M.M....Marchisio P.C. (2003)
    38. The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. (PubMed id 17456594)1, 9 Welm A.L....Bishop J.M. (2007)
    39. The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis. (PubMed id 15764806)1, 9 Matsuzaki S....Mage G. (2005)
    40. The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation. (PubMed id 14597639)1, 9 Angeloni D....Lerman M.I. (2004)
    41. Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding. (PubMed id 10514476)2, 9 Danilkovitch A....Leonard E.J. (1999)
    42. Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism. (PubMed id 10222149)2, 9 Danilkovitch A....Leonard E.J. (1999)
    43. Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor. (PubMed id 7488076)1, 9 Li B.Q....Kamata T. (1995)
    44. The short form of RON is expressed in acute myeloid le ukemia and sensitizes leukemic cells to cMET inhibitors. (PubMed id 22902361)1 Fialin C....Recher C. (2013)
    45. Expression of the recepteur d'originenantais receptor tyrosine kinase in non-small cell lung cancer and its clinical significance. (PubMed id 22613539)1 Han W.L....Zheng S.S. (2012)
    46. Upregulation of recepteur d'origine nantais tyrosine k inase and cell invasiveness via early growth response-1 in gastric cancer cells. (PubMed id 22095683)1 Lee K.E....Jung Y.D. (2012)
    47. A novel variant of the RON receptor tyrosine kinase de rived from colorectal carcinoma cells which lacks tyrosine phosphorylation but i nduces cell migration. (PubMed id 22975341)1 Wang D....He C. (2012)
    48. Expression and mutational status of RON in neoplastic lesions of the breast: analysis of MSP/RON signaling in ductal carcinoma in situ and invasive ductal carcinoma. (PubMed id 22515290)1 Ren X....Yokoyama S. (2012)
    49. Identification of novel splicing variants from RON pro to-oncogene pre-mRNA. (PubMed id 22993024)1 Moon H....Shen H. (2012)
    50. Differential expression of RON in small and non-small cell lung cancers. (PubMed id 22585712)1 Kanteti R....Salgia R. (2012)
    51. Prognostic significance of phosphorylated RON in esoph ageal squamous cell carcinoma. (PubMed id 22086736)1 Hui M.K....Law S. (2012)
    52. RON is not a prognostic marker for resectable pancreat ic cancer. (PubMed id 22958871)1 Tactacan C.M....Daly R.J. (2012)
    53. Knockdown of RON inhibits AP-1 activity and induces ap optosis and cell cycle arrest through the modulation of Akt/FoxO signaling in hu man colorectal cancer cells. (PubMed id 21901254)1 Chung C.Y....Joo Y.E. (2012)
    54. Expression of RON in colorectal cancer and its relatio nships with tumor cell behavior and prognosis. (PubMed id 23235762)1 Park Y.L....Joo Y.E. (2012)
    55. Involvement of recepteur d'origine nantais receptor ty rosine kinase in Epstein-Barr virus-associated nasopharyngeal carcinoma and its metastasis. (PubMed id 22974584)1 Chou Y.C....Tsai C.H. (2012)
    56. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    57. Novel function of transcription factor Nrf2 as an inh ibitor of RON tyrosine kinase receptor-mediated cancer cell invasion. (PubMed id 21799005)1 Thangasamy A....Ammanamanchi S. (2011)
    58. MSP-induced RON activation upregulates uPAR expressio n and cell invasiveness via MAPK, AP-1 and NF-I_B signals in gastric cancer cell s. (PubMed id 21081472)1 Park J.S....Jung Y.D. (2011)
    59. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    60. Small interfering RNA-directed targeting of RON alter s invasive and oncogenic phenotypes of human hepatocellular carcinoma cells. (PubMed id 21874262)1 Cho S.B....Joo Y.E. (2011)
    61. Requirement for LMP1-induced RON receptor tyrosine ki nase in Epstein-Barr virus-mediated B-cell proliferation. (PubMed id 21659546)1 Chou Y.C....Tsai C.H. (2011)
    62. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. (PubMed id 21875933)1 Ganesan R....Kirchhofer D. (2011)
    63. Ron kinase transphosphorylation sustains MET oncogene addiction. (PubMed id 21212418)1 Benvenuti S....Comoglio P.M. (2011)
    64. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    65. Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET. (PubMed id 21784853)2 Chaudhuri A.... Ashkenazi A. (2011)
    66. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    67. RON (MST1R) is a novel prognostic marker and therapeu tic target for gastroesophageal adenocarcinoma. (PubMed id 21543897)1 Catenacci D.V....Salgia R. (2011)
    68. Tyrosine kinase receptor RON and its ligand MSP in Me rkel cell carcinoma. (PubMed id 21723047)1 Nagahama J....Yokoyama S. (2011)
    69. Deletion or insertion in the first immunoglobulin-ple xin-transcription (IPT) domain differentially regulates expression and tumorige nic activities of RON receptor Tyrosine Kinase. (PubMed id 21114864)1 Ma Q....Wang M.H. (2010)
    70. Alterations in a defined extracellular region of the RON receptor tyrosine kinase promote RON-mediated motile and invasive phenotype s in epithelial cells. (PubMed id 19956854)1 Zhang K....Wang M.H. (2010)
    71. An unusual function of RON receptor tyrosine kinase a s a transcriptional regulator in cooperation with EGFR in human cancer cells. (PubMed id 20498137)1 Liu H.S....Chow N.H. (2010)
    72. Ron receptor tyrosine kinase activation confers resis tance to tamoxifen in breast cancer cell lines. (PubMed id 20689759)1 McClaine R.J....Waltz S.E. (2010)
    73. The RON tyrosine kinase receptor regulates vascular e ndothelial growth factor production in pancreatic cancer cells. (PubMed id 20358644)1 Thomas R.M....Lowy A.M. (2010)
    74. Silencing of RON receptor signaling promotes apoptosi s and gemcitabine sensitivity in pancreatic cancers. (PubMed id 20103639)1 Logan-Collins J....Lowy A.M. (2010)
    75. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    76. Small interfering RNA targeting of Recepteur d'Origin e Nantais induces apoptosis via modulation of nuclear factor-kappaB and Bcl-2 f amily in gastric cancer cells. (PubMed id 20664977)1 Park J.S....Jung Y.D. (2010)
    77. The prostate transglutaminase, TGase-4, coordinates w ith the HGFL/MSP-RON system in stimulating the migration of prostate cancer cel ls. (PubMed id 20596668)1 Jiang W.G....Mason M.D. (2010)
    78. The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis. (PubMed id 20726546)2 Wang J.... Crew A.P. (2010)
    79. RON-expressing MCF-10A breast epithelial cells exhibi t alterations of hyaluronan expression, promoting RON-mediated early adhesion e vents. (PubMed id 20026054)1 Feres K.J. and Hayman M.J. (2010)
    80. Chk2*1100delC Acts in synergy with the Ron receptor t yrosine kinase to accelerate mammary tumorigenesis in mice. (PubMed id 20434834)1 Meyer S.E....Waltz S.E. (2010)
    81. Inhibition of MSP-RON signaling pathway in cancer cel ls by a novel soluble form of RON comprising the entire sema sequence. (PubMed id 20428780)1 Ma Q....Wang M.H. (2010)
    82. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    83. Transactivation of RON receptor tyrosine kinase by in teraction with PDGF receptor beta during steady-state growth of human mesangial cells. (PubMed id 19242504)1 Kobayashi T....Kusano E. (2009)
    84. RON receptor tyrosine kinase in human gliomas: expres sion, function, and identification of a novel soluble splice variant. (PubMed id 19519771)1 Eckerich C....Lamszus K. (2009)
    85. The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity. (PubMed id 18209063)1 Klatt A....Henderson A.J. (2008)
    86. Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease. (PubMed id 18200509)1 Beckly J.B....Jewell D.P. (2008)
    87. c-Met must translocate to the nucleus to initiate calcium signals. (PubMed id 18073207)1 Gomes D.A....Nathanson M.H. (2008)
    88. HIV-1 Tat mediates degradation of RON receptor tyrosine kinase, a regulator of inflammation. (PubMed id 18606710)1 Kalantari P....Henderson A.J. (2008)
    89. Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility. (PubMed id 18204077)1 Zhang K....Wang M.H. (2008)
    90. Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160. (PubMed id 18950514)1 Lu Y....Wang M.H. (2008)
    91. Expression of the RON receptor tyrosine kinase and its association with gastric carcinoma versus normal gastric tissues. (PubMed id 19040718)1 Zhou D....Teng X. (2008)
    92. Receptor protein tyrosine kinase Ron is highly expressed in colorectal mucosa of ulcerative colitis patients. (PubMed id 18019691)1 Hirayama I....Kuwano H. (2007)
    93. Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON. (PubMed id 17395888)1 Manzanares D....Salathe M. (2007)
    94. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    95. Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain. (PubMed id 17611409)1 Wang M.H....Yao H.P. (2007)
    96. Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. (PubMed id 16166746)1 Mallakin A....Waltz S.E. (2006)
    97. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    98. Uncoupling ligand-dependent and -independent mechanis ms for mitogen-activated protein kinase activation by the murine Ron receptor t yrosine kinase. (PubMed id 16103119)1 Wei X....Correll P.H. (2005)
    99. The C terminus of RON tyrosine kinase plays an autoinhibitory role. (PubMed id 15632155)2 Yokoyama N.... Miller W.T. (2005)
    100. Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity. (PubMed id 16166096)1 Wei X....Correll P.H. (2005)
    101. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    102. Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors. (PubMed id 14982882)1 van den Akker E....von Lindern M. (2004)
    103. RON receptor tyrosine kinase, a negative regulator of inflammation, inhibits HIV-1 transcription in monocytes/macrophages and is decreased in brain tissue from patients with AIDS. (PubMed id 15557181)1 Lee E.S....Henderson A.J. (2004)
    104. Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential. (PubMed id 12527888)1 Zhou Y.Q....Wang M.H. (2003)
    105. Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais. (PubMed id 12419829)1 Chen Y.Q....Wang M.H. (2002)
    106. Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo. (PubMed id 12214279)1 Chen Y.Q....Wang M.H. (2002)
    107. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. (PubMed id 8918464)1 Iwama A....Suda T. (1996)
    108. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    109. A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. (PubMed id 8247543)1 Lee S.-T.... Spritz R.A. (1993)
    110. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. (PubMed id 7687741)2 Ponzetto C....Comoglio P.M. (1993)
    111. (PubMed id 12472665)2 
    112. Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase. (PubMed id 12807733)9 Wang M.H....Chen Y.Q. (2003)
    113. Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member. (PubMed id 16982759)9 O'Toole J.M....Pereira D.S. (2006)
    114. Activation of the RON receptor tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression. (PubMed id 9794431)9 Chen Y.Q....Wang M.H. (1998)
    115. Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells. (PubMed id 17955509)9 Wang M.H....Yao H.P. (2007)
    116. Collaboration of RON and epidermal growth factor receptor in human bladder carcinogenesis. (PubMed id 17070309)9 Hsu P.Y....Chow N.H. (2006)
    117. Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis. (PubMed id 11593422)9 Peace B.E....Waltz S.E. (2001)
    118. Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src. (PubMed id 10747844)9 Danilkovitch-Miagkova A....Leonard E.J. (2000)
    119. Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines. (PubMed id 11082293)9 Chen Y.Q....Wang M.H. (2000)
    120. Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor. (PubMed id 14499632)9 Peace B.E....Waltz S.E. (2003)
    121. The Ron receptor tyrosine kinase is not required for adenoma formation in Apc(Min/+) mice. (PubMed id 19452510)9 Meyer S.E....Goss K.H. (2009)
    122. RON, a tyrosine kinase receptor involved in tumor progression and metastasis. (PubMed id 15827676)9 Camp E.R....Ellis L.M. (2005)
    123. Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells. (PubMed id 11856768)9 Rampino T....Dal Canton A. (2002)
    124. Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration. (PubMed id 9533936)9 Willett C.G....Sunday M.E. (1998)
    125. Constitutive activation of the RON gene promotes inva sive growth but not transformation. (PubMed id 8943362)9 Santoro M.M....Comoglio P.M. (1996)
    126. Hypermethylation of Ron proximal promoter associates with lack of full-length Ron and transcription of oncogenic short-Ron from an internal promoter. (PubMed id 17297469)9 Angeloni D....Lerman M.I. (2007)
    127. Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation. (PubMed id 17178895)9 Zinser G.M....Waltz S.E. (2006)
    128. Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2. (PubMed id 15363108)9 Miller A.D....Liu S.L. (2004)
    129. Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors. (PubMed id 11332718)9 Danilkovitch-Miagkova A. and Leonard E.J. (2001)
    130. [Evaluation of Ron and Met proto-oncogene expression in epithelial ovarian tumors] (PubMed id 10638160)9 Fracchioli S....Massobrio M. (1999)
    131. Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targets. (PubMed id 17889431)9 Lu Y....Wang M.H. (2007)
    132. Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein. (PubMed id 8950984)9 Wang M.H....Leonard E.J. (1996)
    133. Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancer. (PubMed id 15735014)9 Peace B.E....Waltz S.E. (2005)
    134. Increased c-Met tyrosine kinase expression in segmental renal dysplasia. (PubMed id 12750986)9 Solari V....Puri P. (2003)
    135. Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines. (PubMed id 9214452)9 Chen Q....Zarnegar R. (1997)
    136. The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis. (PubMed id 19576199)9 Meyer S.E....Waltz S.E. (2009)
    137. Characterization of a single-chain intrabody directed against the human receptor tyrosine kinase Ron. (PubMed id 14871539)9 Secco P....Santoro C. (2004)
    138. Feline STK gene expression in mammary carcinomas. (PubMed id 11896610)9 De Maria R....Di Renzo M.F. (2002)
    139. Elevated levels of macrophage-stimulating protein in induced sputum of patients with bronchiectasis. (PubMed id 10955755)9 Takano Y....Ando M. (2000)
    140. Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration. (PubMed id 10631120)9 Xiao Z.Q....Wang M.H. (2000)
    141. Overexpression of the RON gene in human breast carcinoma. (PubMed id 9671413)9 Maggiora P....Comoglio P.M. (1998)
    142. Macrophage-stimulating protein (MSP) and its receptor, RON, stimulate human osteoclast activity but not proliferation: effect of MSP distinct from that of hepatocyte growth factor. (PubMed id 9766449)9 Kurihara N....Suda T. (1998)
    143. Unbiased Screening for Transcriptional Targets of ZKSCAN3 Identifies Integrin {beta}4 and Vascular Endothelial Growth Factor as Downstream Targets. (PubMed id 18940803)9 Yang L....Boyd D.D. (2008)
    144. Ron-receptor tyrosine kinase in tumorigenesis and metastasis. (PubMed id 17661719)9 Leonis M.A....Waltz S.E. (2007)
    145. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. (PubMed id 16364913)9 Ghigna C....Biamonti G. (2005)
    146. Identification of tyrosine kinases overexpressed in head and neck cancer. (PubMed id 15023838)9 Lin H.S....Sun Z. (2004)
    147. C to A single nucleotide polymorphism in intron 18 of the human MST1R (RON) gene that maps at 3p21.3. (PubMed id 12788025)9 Angeloni D....Lerman M.I. (2003)
    148. Structure of the promoter for the human macrophage stimulating protein receptor gene. (PubMed id 7632741)9 Del Gatto F....Breathnach R. (1995)
    149. Inhibition of fatty acid synthase suppresses c-Met re ceptor kinase and induces apoptosis in diffuse large B-cell lymphoma. (PubMed id 20423996)9 Uddin S....Al-Kuraya K.S. (2010)
    150. Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients: evaluation of respiratory burst, cytokine release and NF-kappaB pathway. (PubMed id 16633352)9 Gunella G....Brunelleschi S. (2006)
    151. Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. (PubMed id 15485908)9 Yuan Z.L....Chin Y.E. (2004)
    152. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. (PubMed id 9789329)9 Birchmeier C. and Gherardi E. (1998)
    153. HGF controls branched morphogenesis in tubular glands. (PubMed id 9825897)9 Maffe A. and Comoglio P.M. (1998)
    154. Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors. (PubMed id 9244408)9 Tamagnone L. and Comoglio P.M. (1997)
    155. Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development. (PubMed id 8601032)9 Quantin B....Breathnach R. (1995)
    156. Cancer cells harboring MET gene amplification activat e alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors. (PubMed id 19502802)9 Wang S....Neckers L. (2009)
    157. HGF and c-Met participate in paracrine tumorigenic pa thways in head and neck squamous cell cancer. (PubMed id 19470725)9 Knowles L.M....Siegfried J.M. (2009)
    158. Macrophage stimulating protein may promote tubular regeneration after acute injury. (PubMed id 18614774)9 Cantaluppi V....Camussi G. (2008)
    159. Chemotherapy for metastatic gastric cancer: past, present, and future. (PubMed id 18458840)9 Ohtsu A. (2008)
    160. Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. (PubMed id 17699771)9 Cantiani L....Scotlandi K. (2007)
    161. Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. (PubMed id 16458870)9 Lee W.J....Tseng T.H. (2006)
    162. DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection. (PubMed id 16210010)9 Matsuzaki S....Mage G. (2005)

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