MST1R Gene

Aliases
for MST1R gene

Previous GC identifers: GC03P050091 GC03P050215 GC03M049778 GC03M049884 GC03M049885 GC03M049899

Summaries
for MST1R gene

Genomic Views
for MST1R gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: MST1R promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST1R

MST1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049924:  view genomic region     (about GC identifiers)

Proteins
for MST1R gene

2 PDB 3D structures from and Proteopedia for MST1R:

3PLS (3D)        4FWW (3D)    

Explore the universe of human proteins at neXtProt for MST1R: NX_Q04912

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant MST1R Protein
	R&D Systems Recombinant & Natural Proteins for MST1R (MSP R/Ron)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MST1R OriGene Custom Protein Services for MST1R
	GenScript Custom Purified and Recombinant Proteins Services for MST1R
	Novus Biologicals MST1R Protein Novus Biologicals MST1R Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MST1R

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for MST1R (MSP R/Ron)
	Cell Signaling Technology (CST) Antibodies for MST1R  (Ron)
	OriGene Antibodies: MST1R OriGene Custom Antibody Services for MST1R
	GenScript Custom Superior Antibodies Services for MST1R
	Novus Biologicals MST1R Antibodies
	Abcam antibodies for MST1R
	Uscn Antibodies for MST1R
	ThermoFisher Antibodies for MST1R

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MST1R (MSP R/Ron)         (see all)
	GenScript Custom Assay Services for MST1R
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MST1R

Protein Domains /
Families
for MST1R gene

ProtoNet protein and cluster: Q04912

Function
for MST1R gene

miRNA Products:		OriGene 3'-UTR Clone: MST1R Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MST1R
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MST1R
		SwitchGear 3'UTR luciferase reporter plasmid: MST1R 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MST1R (see all 7) OriGene shRNA RFP: MST1R OriGene siRNA: MST1R
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MST1R

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MST1R

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MST1R (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MST1R (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MST1R (NM_002447)
		Sino Biological Human cDNA Clone for MST1R
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1R
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MST1R
		Search LifeMap BioReagents cell lines for MST1R

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 5 alleles) (MGI details for Mst1r)

Pathways & Interactions
for MST1R gene

	Super-pathway	contained gene-specific pathways
1	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58 P2Y Receptor Signaling 0.38
2	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
3	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48
4	Actin Nucleation by ARP-WASP Complex	Actin Nucleation by ARP-WASP Complex 1.00 CDC42 Pathway 0.34 Actin Nucleation and Branching 0.66
5	Akt Signaling	Akt Signaling 1.00 p38 Signaling 0.60

5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MST1R

	MAPK Signaling
	MSP-RON Signaling
	Paxillin Interactions
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for MST1R

	Angiogenesis
	Tyrosine Kinases / Adaptors

3 BioSystems Pathways for MST1R

	Alpha6-Beta4 Integrin Signaling Pathway
	a6b1 and a6b4 Integrin signaling
	amb2 Integrin signaling

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

Drugs & Compounds
for MST1R gene

Transcripts
for MST1R gene

Expression
for MST1R gene

MST1R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTATGGA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MST1R Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MST1R
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MST1R
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1R

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R

Orthologs
for MST1R gene

Paralogs
for MST1R gene

Paralogs for MST1R gene

AXL²  TIE1²  MET²  RYK²  TEK²  TYRO3²  MERTK²  

18/47 SIMAP similar genes for MST1R using alignment to 5 protein entries:     RON_HUMAN (see all proteins) (see all similar genes):

FLT4    EPHA2    BTK kinase deficient isoform 6    ABL1    tec    SRC

FLT1    CSK    EZR-ROS1    FES    BLK    HCK

FGR    RYK    BTK kinase deficient isoform 2    DKFZp434L0319    EPHA3    EPHA6

MST1R for paralogs           About GeneDecksing

Genomic Variants
for MST1R gene

10/380 NCBI SNPs in MST1R are shown (see all 380)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1816546901,2		--	49923985(+)	TATGCC/TCCAGA	2	--	ds5001		0	--	--	--	--
rs738341181,2	C,	--	49924078(+)	GGGAAA/CGGGGA	2	--	ds5001		2		WA	120
rs1434942441,2		--	49924309(+)	CACTGG/TTTCTG	2	--	ds5001		0	--	--	--	--
rs1462590721,2		--	49924327(+)	TTCCCC/TGGTTG	2	--	ds5001		0	--	--	--	--
rs76152401,2	C,F,H,	--	49924328(+)	TCCCCG/AGTTGA	2	--	ds5001		5		NS EA	540
rs1393280941,2		--	49924422(+)	TCACAC/TTGTTT	2	--	ds5001		0	--	--	--	--
rs117131931,2	C,F,A,H,	--	49924424(+)	ACACTG/ATTTGC	2	--	ds5001		28		NS EA NA WA CSA	2627
rs1440796611,2		--	49924450(+)	AATAGG/TCATTT	2	--	ut31		0	--	--	--	--
rs793280511,2	C,F,	--	49924485(+)	GTGTTG/TGTGTG	2	--	ut31		1		EA	120
rs1413389641,2	C,F	--	49924763(+)	CTCTGA/TGAGTG	4	T S	mis1		1		NA	4552

HapMap Linkage Disequilibrium report for MST1R (49924435 - 49941306 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MST1R: --
Human Gene Mutation Database (HGMD): MST1R

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MST1R

DNA2.0 Custom Variant and Variant Library Synthesis for MST1R

Disorders / Diseases
for MST1R gene

20/32 diseases for MST1R

10/18 Novoseek disease relationships for MST1R gene (see all 18)    About this table

Publications
for MST1R gene

PubMed articles for MST1R gene, integrated from 9 sources (see all 169) (see top 10): (articles sorted by number of sources associating them with MST1R)

Utopia: connect your pdf to the dynamic world of online information

1. A novel putative receptor protein tyrosine kinase of the met family. (PubMed id 8386824)^{1, 2, 3, 9} Ronsin C.... Breathnach R. (1993)
2. c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. (PubMed id 12802274)^{1, 2, 9} Penengo L....Gaudino G. (2003)
3. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. (PubMed id 8062829)^{1, 2, 9} Gaudino G....Comoglio P.M. (1994)
4. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. (PubMed id 7939629)^{1, 2, 9} Wang M.-H.... Breatnach R. (1994)
5. Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)^{1, 2, 9} Conrotto P.... Giordano S. (2004)
6. Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. (PubMed id 22848655)^{1, 2} Chao K.L.... Herzberg O. (2012)
7. The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells. (PubMed id 18836480)^{1, 2} Feres K.J....Hayman M.J. (2009)
8. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)^{1, 2} Jin P.... Paleolog E.M. (2008)
9. Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. (PubMed id 12676986)^{1, 2} Danilkovitch-Miagkova A.... Lerman M.I. (2003)
10. A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. (PubMed id 8816464)^{1, 2} Collesi C.... Comoglio P.M. (1996)
11. Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells. (PubMed id 18593918)^{1, 9} Narasimhan M. and Ammanamanchi S. (2008)
12. Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target. (PubMed id 17311308)^{1, 9} Camp E.R....Ellis L.M. (2007)
13. Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells. (PubMed id 18310076)^{1, 9} Zhao S....Freeman J.W. (2008)
14. Met-related receptor tyrosine kinase Ron in tumor growth and metastasis. (PubMed id 18620091)^{1, 9} Wagh P.K....Waltz S.E. (2008)
15. Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. (PubMed id 16740632)^{1, 9} Germano S....Gaudino G. (2006)
16. Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients. (PubMed id 15788670)^{1, 9} Lee W.Y....Guo H.R. (2005)
17. Recepteur d'Origine Nantais Tyrosine Kinase Is a Direct Target of Hypoxia-inducible Factor-1{alpha}-mediated Invasion of Breast Carcinoma Cells. (PubMed id 19307182)^{1, 9} Thangasamy A....Ammanamanchi S. (2009)
18. Regulation of RON tyrosine kinase-mediated invasion of breast cancer cells. (PubMed id 18165235)^{1, 9} Thangasamy A....Ammanamanchi S. (2008)
19. Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence. (PubMed id 17588532)^{1, 9} Cote M....Liu S.L. (2007)
20. The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells. (PubMed id 19838218)^{1, 9} Thobe M.N....Waltz S.E. (2010)
21. The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness. (PubMed id 12915129)^{1, 9} Maggiora P....Flavia Di Renzo M. (2003)
22. Knockdown of ron kinase inhibits mutant phosphatidylinositol 3-kinase and reduces metastasis in human colon carcinoma. (PubMed id 19224914)^{1, 9} Wang J....Brattain M.G. (2009)
23. Prognostic value of MET, RON and histoprognostic factors for urothelial carcinoma in the upper urinary tract. (PubMed id 18221954)^{1, 9} Comperat E....Cussenot O. (2008)
24. Collaborative activities of macrophage-stimulating protein and transforming growth factor-beta1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase. (PubMed id 15001985)^{1, 9} Wang D....Wang M.H. (2004)
25. The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma. (PubMed id 12766581)^{1, 9} Rampino T....Dal Canton A. (2003)
26. Cross-talk between the proto-oncogenes Met and Ron. (PubMed id 10871856)^{1, 9} Follenzi A....Comoglio P.M. (2000)
27. RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells. (PubMed id 15378025)^{1, 9} Xu X.M....Wang M.H. (2004)
28. Proteolytic cleavage and activation of pro-macrophage-stimulating protein and upregulation of its receptor in tissue injury. (PubMed id 9764835)^{2, 9} Nanney L.B....Leonard E.J. (1998)
29. The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression. (PubMed id 17616662)^{1, 9} Thomas R.M....Lowy A.M. (2007)
30. RON-regulated innate immunity is protective in an animal model of multiple sclerosis. (PubMed id 15929040)^{1, 9} Tsutsui S....Power C. (2005)
31. Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. (PubMed id 9045873)^{1, 9} Sakamoto O....Suda T. (1997)
32. The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. (PubMed id 12919677)^{1, 9} Santoro M.M....Marchisio P.C. (2003)
33. The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. (PubMed id 17456594)^{1, 9} Welm A.L....Bishop J.M. (2007)
34. The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis. (PubMed id 15764806)^{1, 9} Matsuzaki S....Mage G. (2005)
35. The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation. (PubMed id 14597639)^{1, 9} Angeloni D....Lerman M.I. (2004)
36. Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding. (PubMed id 10514476)^{2, 9} Danilkovitch A....Leonard E.J. (1999)
37. Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism. (PubMed id 10222149)^{2, 9} Danilkovitch A....Leonard E.J. (1999)
38. Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor. (PubMed id 7488076)^{1, 9} Li B.Q....Kamata T. (1995)
39. Expression of the recepteur d'originenantais receptor tyrosine kinase in non-small cell lung cancer and its clinical significance. (PubMed id 22613539)¹ Han W.L....Zheng S.S. (2012)
40. Upregulation of recepteur d'origine nantais tyrosine k inase and cell invasiveness via early growth response-1 in gastric cancer cells. (PubMed id 22095683)¹ Lee K.E....Jung Y.D. (2012)
41. A novel variant of the RON receptor tyrosine kinase de rived from colorectal carcinoma cells which lacks tyrosine phosphorylation but i nduces cell migration. (PubMed id 22975341)¹ Wang D....He C. (2012)
42. Expression and mutational status of RON in neoplastic lesions of the breast: analysis of MSP/RON signaling in ductal carcinoma in situ and invasive ductal carcinoma. (PubMed id 22515290)¹ Ren X....Yokoyama S. (2012)
43. Differential expression of RON in small and non-small cell lung cancers. (PubMed id 22585712)¹ Kanteti R....Salgia R. (2012)
44. Knockdown of RON inhibits AP-1 activity and induces ap optosis and cell cycle arrest through the modulation of Akt/FoxO signaling in hu man colorectal cancer cells. (PubMed id 21901254)¹ Chung C.Y....Joo Y.E. (2012)
45. Expression of RON in colorectal cancer and its relatio nships with tumor cell behavior and prognosis. (PubMed id 23235762)¹ Park Y.L....Joo Y.E. (2012)
46. Novel function of transcription factor Nrf2 as an inh ibitor of RON tyrosine kinase receptor-mediated cancer cell invasion. (PubMed id 21799005)¹ Thangasamy A....Ammanamanchi S. (2011)
47. MSP-induced RON activation upregulates uPAR expressio n and cell invasiveness via MAPK, AP-1 and NF-I_B signals in gastric cancer cell s. (PubMed id 21081472)¹ Park J.S....Jung Y.D. (2011)
48. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
49. Small interfering RNA-directed targeting of RON alter s invasive and oncogenic phenotypes of human hepatocellular carcinoma cells. (PubMed id 21874262)¹ Cho S.B....Joo Y.E. (2011)
50. Requirement for LMP1-induced RON receptor tyrosine ki nase in Epstein-Barr virus-mediated B-cell proliferation. (PubMed id 21659546)¹ Chou Y.C....Tsai C.H. (2011)
51. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. (PubMed id 21875933)¹ Ganesan R....Kirchhofer D. (2011)
52. Ron kinase transphosphorylation sustains MET oncogene addiction. (PubMed id 21212418)¹ Benvenuti S....Comoglio P.M. (2011)
53. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
54. Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET. (PubMed id 21784853)² Chaudhuri A.... Ashkenazi A. (2011)
55. RON (MST1R) is a novel prognostic marker and therapeu tic target for gastroesophageal adenocarcinoma. (PubMed id 21543897)¹ Catenacci D.V....Salgia R. (2011)
56. Tyrosine kinase receptor RON and its ligand MSP in Me rkel cell carcinoma. (PubMed id 21723047)¹ Nagahama J....Yokoyama S. (2011)
57. Deletion or insertion in the first immunoglobulin-ple xin-transcription (IPT) domain differentially regulates expression and tumorige nic activities of RON receptor Tyrosine Kinase. (PubMed id 21114864)¹ Ma Q....Wang M.H. (2010)
58. Alterations in a defined extracellular region of the RON receptor tyrosine kinase promote RON-mediated motile and invasive phenotype s in epithelial cells. (PubMed id 19956854)¹ Zhang K....Wang M.H. (2010)
59. An unusual function of RON receptor tyrosine kinase a s a transcriptional regulator in cooperation with EGFR in human cancer cells. (PubMed id 20498137)¹ Liu H.S....Chow N.H. (2010)
60. Ron receptor tyrosine kinase activation confers resis tance to tamoxifen in breast cancer cell lines. (PubMed id 20689759)¹ McClaine R.J....Waltz S.E. (2010)
61. The RON tyrosine kinase receptor regulates vascular e ndothelial growth factor production in pancreatic cancer cells. (PubMed id 20358644)¹ Thomas R.M....Lowy A.M. (2010)
62. Silencing of RON receptor signaling promotes apoptosi s and gemcitabine sensitivity in pancreatic cancers. (PubMed id 20103639)¹ Logan-Collins J....Lowy A.M. (2010)
63. Small interfering RNA targeting of Recepteur d'Origin e Nantais induces apoptosis via modulation of nuclear factor-kappaB and Bcl-2 f amily in gastric cancer cells. (PubMed id 20664977)¹ Park J.S....Jung Y.D. (2010)
64. The prostate transglutaminase, TGase-4, coordinates w ith the HGFL/MSP-RON system in stimulating the migration of prostate cancer cel ls. (PubMed id 20596668)¹ Jiang W.G....Mason M.D. (2010)
65. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)¹ Flachsbart F....Nebel A. (2010)
66. The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis. (PubMed id 20726546)² Wang J.... Crew A.P. (2010)
67. RON-expressing MCF-10A breast epithelial cells exhibi t alterations of hyaluronan expression, promoting RON-mediated early adhesion e vents. (PubMed id 20026054)¹ Feres K.J. and Hayman M.J. (2010)
68. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
69. Chk2*1100delC Acts in synergy with the Ron receptor t yrosine kinase to accelerate mammary tumorigenesis in mice. (PubMed id 20434834)¹ Meyer S.E....Waltz S.E. (2010)
70. Inhibition of MSP-RON signaling pathway in cancer cel ls by a novel soluble form of RON comprising the entire sema sequence. (PubMed id 20428780)¹ Ma Q....Wang M.H. (2010)
71. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)¹ So H.C....Sham P.C. (2009)
72. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
73. Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility. (PubMed id 19657358)¹ MA!rquez A....Urcelay E. (2009)
74. Transactivation of RON receptor tyrosine kinase by in teraction with PDGF receptor beta during steady-state growth of human mesangial cells. (PubMed id 19242504)¹ Kobayashi T....Kusano E. (2009)
75. RON receptor tyrosine kinase in human gliomas: expres sion, function, and identification of a novel soluble splice variant. (PubMed id 19519771)¹ Eckerich C....Lamszus K. (2009)
76. The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity. (PubMed id 18209063)¹ Klatt A....Henderson A.J. (2008)
77. Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease. (PubMed id 18200509)¹ Beckly J.B....Jewell D.P. (2008)
78. c-Met must translocate to the nucleus to initiate calcium signals. (PubMed id 18073207)¹ Gomes D.A....Nathanson M.H. (2008)
79. HIV-1 Tat mediates degradation of RON receptor tyrosine kinase, a regulator of inflammation. (PubMed id 18606710)¹ Kalantari P....Henderson A.J. (2008)
80. Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility. (PubMed id 18204077)¹ Zhang K....Wang M.H. (2008)
81. Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160. (PubMed id 18950514)¹ Lu Y....Wang M.H. (2008)
82. Expression of the RON receptor tyrosine kinase and its association with gastric carcinoma versus normal gastric tissues. (PubMed id 19040718)¹ Zhou D....Teng X. (2008)
83. Receptor protein tyrosine kinase Ron is highly expressed in colorectal mucosa of ulcerative colitis patients. (PubMed id 18019691)¹ Hirayama I....Kuwano H. (2007)
84. Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON. (PubMed id 17395888)¹ Manzanares D....Salathe M. (2007)
85. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)² Greenman C.... Stratton M.R. (2007)
86. Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain. (PubMed id 17611409)¹ Wang M.H....Yao H.P. (2007)
87. Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. (PubMed id 16166746)¹ Mallakin A....Waltz S.E. (2006)
88. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
89. Uncoupling ligand-dependent and -independent mechanis ms for mitogen-activated protein kinase activation by the murine Ron receptor t yrosine kinase. (PubMed id 16103119)¹ Wei X....Correll P.H. (2005)
90. The C terminus of RON tyrosine kinase plays an autoinhibitory role. (PubMed id 15632155)² Yokoyama N.... Miller W.T. (2005)
91. Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity. (PubMed id 16166096)¹ Wei X....Correll P.H. (2005)
92. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
93. Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors. (PubMed id 14982882)¹ van den Akker E....von Lindern M. (2004)
94. RON receptor tyrosine kinase, a negative regulator of inflammation, inhibits HIV-1 transcription in monocytes/macrophages and is decreased in brain tissue from patients with AIDS. (PubMed id 15557181)¹ Lee E.S....Henderson A.J. (2004)
95. Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential. (PubMed id 12527888)¹ Zhou Y.Q....Wang M.H. (2003)
96. Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais. (PubMed id 12419829)¹ Chen Y.Q....Wang M.H. (2002)
97. Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo. (PubMed id 12214279)¹ Chen Y.Q....Wang M.H. (2002)
98. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. (PubMed id 8918464)¹ Iwama A....Suda T. (1996)
99. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
100. A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. (PubMed id 8247543)¹ Lee S.-T.... Spritz R.A. (1993)
101. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. (PubMed id 7687741)² Ponzetto C....Comoglio P.M. (1993)
102. (PubMed id 12472665)² 
103. Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase. (PubMed id 12807733)⁹ Wang M.H....Chen Y.Q. (2003)
104. Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member. (PubMed id 16982759)⁹ O'Toole J.M....Pereira D.S. (2006)
105. Activation of the RON receptor tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression. (PubMed id 9794431)⁹ Chen Y.Q....Wang M.H. (1998)
106. Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells. (PubMed id 17955509)⁹ Wang M.H....Yao H.P. (2007)
107. Collaboration of RON and epidermal growth factor receptor in human bladder carcinogenesis. (PubMed id 17070309)⁹ Hsu P.Y....Chow N.H. (2006)
108. Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis. (PubMed id 11593422)⁹ Peace B.E....Waltz S.E. (2001)
109. Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src. (PubMed id 10747844)⁹ Danilkovitch-Miagkova A....Leonard E.J. (2000)
110. Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines. (PubMed id 11082293)⁹ Chen Y.Q....Wang M.H. (2000)
111. Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor. (PubMed id 14505491)⁹ Santoro M.M....Villa-Moruzzi E. (2003)
112. Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor. (PubMed id 14499632)⁹ Peace B.E....Waltz S.E. (2003)
113. The Ron receptor tyrosine kinase is not required for adenoma formation in Apc(Min/+) mice. (PubMed id 19452510)⁹ Meyer S.E....Goss K.H. (2009)
114. RON, a tyrosine kinase receptor involved in tumor progression and metastasis. (PubMed id 15827676)⁹ Camp E.R....Ellis L.M. (2005)
115. Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells. (PubMed id 11856768)⁹ Rampino T....Dal Canton A. (2002)
116. Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration. (PubMed id 9533936)⁹ Willett C.G....Sunday M.E. (1998)
117. Constitutive activation of the RON gene promotes inva sive growth but not transformation. (PubMed id 8943362)⁹ Santoro M.M....Comoglio P.M. (1996)
118. Hypermethylation of Ron proximal promoter associates with lack of full-length Ron and transcription of oncogenic short-Ron from an internal promoter. (PubMed id 17297469)⁹ Angeloni D....Lerman M.I. (2007)
119. Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation. (PubMed id 17178895)⁹ Zinser G.M....Waltz S.E. (2006)
120. Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2. (PubMed id 15363108)⁹ Miller A.D....Liu S.L. (2004)
121. Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors. (PubMed id 11332718)⁹ Danilkovitch-Miagkova A. and Leonard E.J. (2001)
122. [Evaluation of Ron and Met proto-oncogene expression in epithelial ovarian tumors] (PubMed id 10638160)⁹ Fracchioli S....Massobrio M. (1999)
123. Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targets. (PubMed id 17889431)⁹ Lu Y....Wang M.H. (2007)
124. Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein. (PubMed id 8950984)⁹ Wang M.H....Leonard E.J. (1996)
125. Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancer. (PubMed id 15735014)⁹ Peace B.E....Waltz S.E. (2005)
126. Increased c-Met tyrosine kinase expression in segmental renal dysplasia. (PubMed id 12750986)⁹ Solari V....Puri P. (2003)
127. Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines. (PubMed id 9214452)⁹ Chen Q....Zarnegar R. (1997)
128. The Ron receptor tyrosine kinase negatively regulates mammary gland branching morphogenesis. (PubMed id 19576199)⁹ Meyer S.E....Waltz S.E. (2009)
129. Characterization of a single-chain intrabody directed against the human receptor tyrosine kinase Ron. (PubMed id 14871539)⁹ Secco P....Santoro C. (2004)
130. Feline STK gene expression in mammary carcinomas. (PubMed id 11896610)⁹ De Maria R....Di Renzo M.F. (2002)
131. Elevated levels of macrophage-stimulating protein in induced sputum of patients with bronchiectasis. (PubMed id 10955755)⁹ Takano Y....Ando M. (2000)
132. Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration. (PubMed id 10631120)⁹ Xiao Z.Q....Wang M.H. (2000)
133. Overexpression of the RON gene in human breast carcinoma. (PubMed id 9671413)⁹ Maggiora P....Comoglio P.M. (1998)
134. Macrophage-stimulating protein (MSP) and its receptor, RON, stimulate human osteoclast activity but not proliferation: effect of MSP distinct from that of hepatocyte growth factor. (PubMed id 9766449)⁹ Kurihara N....Suda T. (1998)
135. Unbiased Screening for Transcriptional Targets of ZKSCAN3 Identifies Integrin {beta}4 and Vascular Endothelial Growth Factor as Downstream Targets. (PubMed id 18940803)⁹ Yang L....Boyd D.D. (2008)
136. Ron-receptor tyrosine kinase in tumorigenesis and metastasis. (PubMed id 17661719)⁹ Leonis M.A....Waltz S.E. (2007)
137. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. (PubMed id 16364913)⁹ Ghigna C....Biamonti G. (2005)
138. Identification of tyrosine kinases overexpressed in head and neck cancer. (PubMed id 15023838)⁹ Lin H.S....Sun Z. (2004)
139. C to A single nucleotide polymorphism in intron 18 of the human MST1R (RON) gene that maps at 3p21.3. (PubMed id 12788025)⁹ Angeloni D....Lerman M.I. (2003)
140. Structure of the promoter for the human macrophage stimulating protein receptor gene. (PubMed id 7632741)⁹ Del Gatto F....Breathnach R. (1995)
141. Inhibition of fatty acid synthase suppresses c-Met re ceptor kinase and induces apoptosis in diffuse large B-cell lymphoma. (PubMed id 20423996)⁹ Uddin S....Al-Kuraya K.S. (2010)
142. Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients: evaluation of respiratory burst, cytokine release and NF-kappaB pathway. (PubMed id 16633352)⁹ Gunella G....Brunelleschi S. (2006)
143. Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. (PubMed id 15485908)⁹ Yuan Z.L....Chin Y.E. (2004)
144. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. (PubMed id 9789329)⁹ Birchmeier C. and Gherardi E. (1998)
145. HGF controls branched morphogenesis in tubular glands. (PubMed id 9825897)⁹ Maffe A. and Comoglio P.M. (1998)
146. Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors. (PubMed id 9244408)⁹ Tamagnone L. and Comoglio P.M. (1997)
147. Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development. (PubMed id 8601032)⁹ Quantin B....Breathnach R. (1995)
148. Cancer cells harboring MET gene amplification activat e alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors. (PubMed id 19502802)⁹ Wang S....Neckers L. (2009)
149. HGF and c-Met participate in paracrine tumorigenic pa thways in head and neck squamous cell cancer. (PubMed id 19470725)⁹ Knowles L.M....Siegfried J.M. (2009)
150. Macrophage stimulating protein may promote tubular regeneration after acute injury. (PubMed id 18614774)⁹ Cantaluppi V....Camussi G. (2008)
151. Chemotherapy for metastatic gastric cancer: past, present, and future. (PubMed id 18458840)⁹ Ohtsu A. (2008)
152. Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. (PubMed id 17699771)⁹ Cantiani L....Scotlandi K. (2007)
153. Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. (PubMed id 16458870)⁹ Lee W.J....Tseng T.H. (2006)
154. DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection. (PubMed id 16210010)⁹ Matsuzaki S....Mage G. (2005)
155. The sema domain. (PubMed id 15582390)⁹ Gherardi E....Jones E.Y. (2004)
156. NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics. (PubMed id 12824898)⁹ Matsumoto K. and Nakamura T. (2003)
157. Evaluation of the c-Met immunostain to detect malignant cells in body cavity effusions. (PubMed id 11605063)⁹ Zimmerman R.L. and Fogt F. (2001)
158. The Ron oncogenic activity induced by the MEN2B-like substitution overcomes the requirement for the multifunctional docking site. (PubMed id 11064459)⁹ Santoro M.M....Gaudino G. (2000)
159. PPARgamma inhibits the expression of c-MET in human gastric cancer cells through the suppression of Ets. (PubMed id 10558888)⁹ Kitamura S....Matsuzawa Y. (1999)
160. Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway. (PubMed id 9182684)⁹ van der Voort R....Pals S.T. (1997)
161. Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival. (PubMed id 9185522)⁹ Willett C.G....Sunday M.E. (1997)
162. Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes. (PubMed id 8660937)⁹ Wang M.H....Leonard E.J. (1996)

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