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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MST1R Gene

protein-coding   GIFtS: 68
GCID: GC03M049924

Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine...

(Previous name: PTK8 protein tyrosine kinase 8)
(Previous symbols: RON, PTK8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Macrophage Stimulating 1 Receptor (C-Met-Related Tyrosine Kinase)1 2     MST1R Variant RON302
RON1 2 3 5     MST1R Variant RON622
PTK81 2 3     RON Variant 212
PTK8 Protein Tyrosine Kinase 81 2     RON Variant E2E32
CDw1362 3     Soluble RON Variant 12
MSP Receptor2 3     Soluble RON Variant 22
p185-Ron2 3     Soluble RON Variant 32
EC 2.7.10.13 8     Soluble RON Variant 42
CD1362     CD136 Antigen3
C-Met-Related Tyrosine Kinase2     Protein-Tyrosine Kinase 83
Macrophage-Stimulating Protein Receptor2     EC 2.7.108

External Ids:    HGNC: 73811   Entrez Gene: 44862   Ensembl: ENSG000001640787   OMIM: 6001685   UniProtKB: Q049123   

Export aliases for MST1R gene to outside databases

Previous GC identifers: GC03P050091 GC03P050215 GC03M049778 GC03M049884 GC03M049885 GC03M049899


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MST1R Gene:
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity.
The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by
proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon
stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of
the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript
variants encoding different isoforms with different structural and biochemical properties have been described
(PMID:8816464). (provided by RefSeq, Oct 2011)

GeneCards Summary for MST1R Gene: 
MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase)) is a protein-coding gene. Diseases associated with MST1R include renal oncocytoma, and benign tumors, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include macrophage colony-stimulating factor receptor activity and enzyme binding. An important paralog of this gene is AXL.

UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and
differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular
domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts
with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON
leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON
signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as
survival at the wound site. Plays also a role in the innate immune response by regulating the migration and
phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and
proliferation in response to growth factors other than MST1 ligand

Gene Wiki entry for MST1R Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MST1R gene promoter:
         E2F   E2F-1   STAT3   E2F-2   STAT5A   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMST1R promoter sequence
   Search SABiosciences Chromatin IP Primers for MST1R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST1R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

MST1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1R gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049924:  view genomic region     (about GC identifiers)

Start:
49,924,435 bp from pter      End:
49,941,306 bp from pter
Size:
16,872 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RON_HUMAN, Q04912 (See protein sequence)
Recommended Name: Macrophage-stimulating protein receptor precursor  
Size: 1400 amino acids; 152271 Da
Subunit: Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with
and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1,
PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for MST1R:
3PLS (3D)        4FWW (3D)    
Secondary accessions: B5A944 B5A945 B5A946 B5A947
Alternative splicing: 6 isoforms:  Q04912-1   Q04912-2   Q04912-3   Q04912-4   Q04912-5   Q04912-6   (Lacks part of the extracellular domain, oligomerizes and is constitutively activated)

Explore the universe of human proteins at neXtProt for MST1R: NX_Q04912

Explore proteomics data for MST1R at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytic processing yields the two subunits
  • UniProtKB: Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further
    phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site
  • UniProtKB: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04912

  • 4/9 DME Specific Peptides for MST1R (Q04912) (see all 9)
     FVHRDLA  QVARGME  QPEYCPD  RDLAARN 

    MST1R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MST1R Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231866.1  NP_002438.2  

    ENSEMBL proteins: 
     ENSP00000296474   ENSP00000407926   ENSP00000341325   ENSP00000393294   ENSP00000414792  

    Human Recombinant Protein Products for MST1R: 
    EMD Millipore Purified and/or Recombinant MST1R Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MST1R
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MST1R
    GenScript Custom Purified and Recombinant Proteins Services for MST1R
    Novus Biologicals MST1R Protein
    Novus Biologicals MST1R Lysate
    Sino Biological Recombinant Protein for MST1R
    Sino Biological Cell Lysate for MST1R 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MST1R 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS7939629
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    MST1R for ontologies           About GeneDecksing



    MST1R Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MST1R (MSP R/Ron)
    Cell Signaling Technology (CST) Antibodies for MST1R  (Ron)
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    GenScript Custom Superior Antibodies Services for MST1R
    Novus Biologicals MST1R Antibodies
    Abcam antibodies for MST1R
    Cloud-Clone Corp. Antibodies for MST1R 
    ThermoFisher Antibodies for MST1R
    LSBio Antibodies in human, mouse, rat for MST1R 

    Assay Products for MST1R: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for MST1R (MSP R/Ron)         (see all)
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for MST1R (Ron)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MST1R 
    Cloud-Clone Corp. CLIAs for MST1R


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: macrophage stimulating 1 receptor (c-met-related tyrosine kinase) 
    Met family
    HGF (hepatocyte growth factor) receptor family

    5/14 InterPro protein domains (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR014756 Ig_E-set
     IPR002909 IPT_TIG_rcpt
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q04912

    ProtoNet protein and cluster: Q04912

    2 Blocks protein domains:
    IPB002909 Cell surface receptor IPT/TIG
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 3 IPT/TIG domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Sema domain


    MST1R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RON_HUMAN, Q04912
    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by
    binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and
    differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular
    domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts
    with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON
    leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON
    signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as
    survival at the wound site. Plays also a role in the innate immune response by regulating the migration and
    phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and
    proliferation in response to growth factors other than MST1 ligand
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the
    kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus
    increasing the kinase activity

         Genatlas biochemistry entry for MST1R:
    macrophage stimulating protein 1 receptor,hepacyte growth factor receptor (MET) related,involved in development of
    epithelial tissue,bone,neuroendocrine derivatives,paralog to MET,stem cell tyrosine kinase receptor (Stk)
    homolog,conferring susceptibility to friend virus induced erythroleukemia in mice

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0004872receptor activity ----
    GO:0005011macrophage colony-stimulating factor receptor activity TAS9045873
         
    MST1R for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MST1R:
     Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mst1r):
     endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging  reproductive system 

    MST1R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MST1R: Mst1rtm1Sjd Mst1rtm1.1Sew

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MST1R 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MST1R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MST1R 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MST1R 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MST1R
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MST1R
    SwitchGear 3'UTR luciferase reporter plasmidMST1R 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MST1R (NM_002447)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1R
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                         Customized lentivirus expression plasmids for stable overexpression of MST1R 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1R


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MST1R About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MST1R (see all 30)
        MAPK Signaling
    MSP-RON Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for MST1R
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 BioSystems Pathways for MST1R
        Alpha6-Beta4 Integrin Signaling Pathway
    a6b1 and a6b4 Integrin signaling
    amb2 Integrin signaling




    MST1R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MST1R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for MST1R (Q049121, 2, 3 ENSP000002964744) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNB1O431571, 3, ENSP000002964404EBI-2637518,EBI-1111488 I2D: score=1 STRING: ENSP00000296440
    PLXNB3Q9ULL41, 3, ENSP000003553784EBI-2637518,EBI-311073 I2D: score=1 STRING: ENSP00000355378
    CBLP226812, 3, ENSP000002640334MINT-6539679 I2D: score=2 STRING: ENSP00000264033
    YWHAZP631042, 3, ENSP000003095034MINT-8006508 I2D: score=2 STRING: ENSP00000309503
    YWHAQP273482, 3, ENSP000002380814MINT-8006465 I2D: score=2 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006928cellular component movement TAS9045873
    GO:0006952defense response TAS9045873
    GO:0007165signal transduction TAS7939629
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--

    MST1R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MST1R for compounds           About GeneDecksing

    EMD Millipore small molecules for MST1R:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MST1R (RON)

    2 HMDB Compounds for MST1R    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 IUPHAR Ligand for MST1R (macrophage stimulating 1 receptor (c-met-related tyrosine kinase))    About this table 
    LigandTypeActionAffinityPubmed IDs
    macrophage stimulating protein 1
    NoneNone--

    5 Novoseek inferred chemical compound relationships for MST1R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 76.6 79 18593918 (4), 19307182 (3), 15827676 (2), 11332718 (2) (see all 47)
    wortmannin 48.9 2 9794431 (1), 14505491 (1)
    pd 98,059 17.1 1 15001985 (1)
    phosphatidylinositol 11.8 3 19224914 (1)
    serine 11.3 1 14505491 (1)

    Search CenterWatch for drugs/clinical trials and news about MST1R / RON

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MST1R gene (2 alternative transcripts): 
    NM_001244937.1  NM_002447.2  

    Unigene Cluster for MST1R:

    Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
    Hs.517973  [show with all ESTs]
    Unigene Representative Sequence: NM_002447
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296474 ENST00000411578(uc003cxy.4 uc011bdc.2 uc011bde.1 uc011bdf.1 uc011bdg.2)
    ENST00000344206 ENST00000434765 ENST00000440292 ENST00000463789 ENST00000490053
    ENST00000467110 ENST00000468525 ENST00000493535 ENST00000485044 ENST00000497001

    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1R
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1R
    Sirion Biotech Customized lentivirus for stable overexpression of MST1R 
                         Customized lentivirus expression plasmids for stable overexpression of MST1R 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1R

    Additional mRNA sequence: 

    AK303234.1 EU826582.1 EU826583.1 EU826584.1 EU826585.1 HQ908652.1 JN983806.1 X70040.1 

    7 DOTS entries:

    DT.211894  DT.120879705  DT.91904328  DT.100754685  DT.92417911  DT.96086513  DT.97837134 

    24/72 AceView cDNA sequences (see all 72):

    BG823879 BX505902 AW179110 BU542597 AI659677 BX280864 BM044732 BM790561 
    BM048043 BM795098 BX479000 AA173453 BM796337 BG289902 BM047000 BQ919273 
    BQ900191 BU541700 BM044054 CA503122 AI651503 BF094070 AI675684 BU500594 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MST1R    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                    -                       -     -           -                                             
    SP2:                                                                    -     -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                             
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MST1R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MST1R expression in normal human tissues (normalized intensities)      MST1R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATGGA
    MST1R Expression
    About this image


    MST1R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colonic mucosal (ibs)   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Bone (Muscoskeletal System)
             Endochondral Facial Bones
     
     Stomach (Gastrointestinal Tract)

    See MST1R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MST1R

    SOURCE GeneReport for Unigene cluster: Hs.517973

    UniProtKB/Swiss-Prot: RON_HUMAN, Q04912
    Tissue specificity: Expressed in colon, skin, lung and bone marrow

        SABiosciences Expression via Pathway-Focused PCR Array including MST1R: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MST1R gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mst1r1 , 5 macrophage stimulating 1 receptor (c-met-related tyrosine more1, 5 78.34(n)1
    76.1(a)1
      9 (59.07 cM)5
    198821  NM_009074.21  NP_033100.21 
     1079068895 
    chicken
    (Gallus gallus)
    Aves MST1R1 macrophage stimulating 1 receptor (c-met-related tyrosine more 59.24(n)
    49.47(a)
      427573  NM_001031463.1  NP_001026634.1 
    lizard
    (Anolis carolinensis)
    Reptilia MST1R6
    Uncharacterized protein
    38(a)
    1 ↔ 1
    2(147875611-147953639)
    African clawed frog
    (Xenopus laevis)
    Amphibia D87758.12   -- 75.07(n)    D87758.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mst1rb1 macrophage stimulating 1 receptor (c-met-related tyrosine more 49.87(n)
    43.38(a)
      100134855  XM_002663812.1  XP_002663858.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F11E6.83 Eukaryotic protein kinase domain 49(a)
    (best of 9)
      IV(17444692-17450635)   --


    ENSEMBL Gene Tree for MST1R (if available)
    TreeFam Gene Tree for MST1R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MST1R gene
    AXL2  MET2  RYK2  TYRO32  MERTK2  
    18/71 SIMAP similar genes for MST1R using alignment to 4 protein entries:     RON_HUMAN (see all proteins) (see all similar genes):
    RON    FLT4    EPHA2    BTK kinase deficient isoform 6    ABL1    tec
    SRC    AXL    FLT1    CSK    EZR-ROS1    LRIG3(NM_001136051)-ROS1
    LRIG3(NM_153377)-ROS1    R32    R34    SLC34A2-ROS1    TPM3-ROS1    FES

    MST1R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/571 SNPs in MST1R are shown (see all 571)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0617494
    ----see VAR_0617492 S G mis40--------
    VAR_0417774
    ----see VAR_0417772 R G mis40--------
    rs1816546901,2
    --49855997(+) TATGCC/TCCAGA 2 -- ds50010--------
    rs738341181,2
    C,F--49856090(+) GGGAAA/CGGGGA 2 -- ds50012Minor allele frequency- C:0.13WA 120
    rs1434942441,2
    --49856321(+) CACTGG/TTTCTG 2 -- ds50010--------
    rs1462590721,2
    --49856339(+) TTCCCC/TGGTTG 2 -- ds50010--------
    rs76152401,2
    C,F,H--49856340(+) tccccG/Agttga 2 -- ds50015Minor allele frequency- A:0.02NS EA 540
    rs1393280941,2
    --49856434(+) TCACAC/TTGTTT 2 -- ds50010--------
    rs117131931,2
    C,F,A,H--49856436(+) ACACTG/ATTTGC 2 -- ds500128Minor allele frequency- A:0.38NS EA NA WA CSA 2627
    rs1440796611,2
    C--49856462(+) AATAGG/TCATTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MST1R (49924435 - 49941306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MST1R:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876767CNV Loss21882294
    nsv876766CNV Loss21882294
    nsv834688CNV Loss17160897


    Human Gene Mutation Database (HGMD): MST1R
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600168    OMIM disorders: --

    20/35 diseases for MST1R (see all 35):    About MalaCards
    renal oncocytoma    benign tumors    renal dysplasia    gallbladder cancer
    bronchiectasis    endometriosis    pancreatic cancer    diffuse large b-cell lymphoma
    ductal carcinoma in situ    b-cell lymphomas    thyroid cancer    ulcerative colitis
    peritonitis    crohn's disease    multiple sclerosis    osteosarcoma
    pancreatitis    gastric cancer    inflammatory bowel disease    hypoxia


    MST1R for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for MST1R gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 44.6 22 15735014 (3), 15827676 (2), 17178895 (2), 18620091 (2) (see all 12)
    breast carcinoma 41.6 5 9671413 (2), 11896610 (1), 18593918 (1), 15788670 (1)
    tumors 38.6 40 15827676 (4), 19452510 (3), 17661719 (2), 11593422 (2) (see all 22)
    cancer 35.9 39 16982759 (5), 17955509 (4), 17889431 (4), 18620091 (3) (see all 13)
    pancreatic cancer 31 9 17311308 (6), 17616662 (2)
    lung tumor 28.2 2 15827676 (1), 9533936 (1)
    breast cancer 27.5 21 19307182 (4), 15788670 (4), 18593918 (3), 17178895 (2) (see all 9)
    carcinoma 24.9 13 12766581 (2), 9533936 (2), 18593918 (1), 11082293 (1) (see all 6)
    colon cancer 16.9 1 15378025 (1), 19224914 (1)
    mammary tumor 16.8 3 15735014 (3)

    Genetic Association Database (GAD): MST1R
    Human Genome Epidemiology (HuGE) Navigator: MST1R (8 documents)

    Export disorders for MST1R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MST1R gene, integrated from 9 sources (see all 177):
    (articles sorted by number of sources associating them with MST1R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel putative receptor protein tyrosine kinase of the met family. (PubMed id 8386824)1, 2, 3, 9 Ronsin C.... Breathnach R. (1993)
    2. c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. (PubMed id 12802274)1, 2, 9 Penengo L....Gaudino G. (2003)
    3. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. (PubMed id 8062829)1, 2, 9 Gaudino G....Comoglio P.M. (1994)
    4. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. (PubMed id 7939629)1, 2, 9 Wang M.-H.... Breatnach R. (1994)
    5. Interplay between scatter factor receptors and B plexins controls invasive growth. (PubMed id 15184888)1, 2, 9 Conrotto P.... Giordano S. (2004)
    6. Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. (PubMed id 22848655)1, 2 Chao K.L.... Herzberg O. (2012)
    7. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    10. Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility. (PubMed id 19657358)1, 4 MA!rquez A....Urcelay E. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4486 HGNC: 7381 AceView: MST1R Ensembl:ENSG00000164078 euGenes: HUgn4486
    ECgene: MST1R H-InvDB: MST1R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MST1R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MST1R Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MST1R gene:
    Search GeneIP for patents involving MST1R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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