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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MST1L Gene

pseudogene   GIFtS: 28
GCID: GC01M017083

Macrophage Stimulating 1-Like

(Previous names: macrophage stimulating, pseudogene 7, macrophage stimulating,...)
(Previous symbols: MSTP7, MSTP9, MST1P9)
  Search for MST1L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Macrophage Stimulating 1-Like1 2     BRF-12 3
MST1P91 2 3     D1F15S1A2 3
MSTP91 2 3     MSPL-72
MSTP71 2     MSPL72
Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) Pseudogene 91 2     brain-rescue-factor-12
Macrophage Stimulating, Pseudogene 71 2     Putative Macrophage Stimulating 1-Like Protein2
Macrophage Stimulating, Pseudogene 91 2     Putative Macrophage-Stimulating Protein MSTP92
Brain Rescue Factor 12 3     Hepatocyte Growth Factor-Like Protein Homolog3

External Ids:    HGNC: 73901   Entrez Gene: 112232   Ensembl: ENSG000001867157   UniProtKB: Q2TV783   
ORGUL members:         
NONCODE14:n405572 n346006      

Export aliases for MST1L gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MST1L Gene: 
MST1L (macrophage stimulating 1-like) is a pseudogene, and is affiliated with the lncRNA class. GO annotations related to this gene include serine-type endopeptidase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MST1L
         Other transcription factors

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   Search SABiosciences Chromatin IP Primers for MST1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.33

MST1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M017083:  view genomic region     (about GC identifiers)

Start:
17,081,401 bp from pter      End:
17,096,732 bp from pter
Size:
15,332 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MST1L

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: MST1L_HUMAN, Q2TV78 (See protein sequence)
Recommended Name: Putative macrophage stimulating 1-like protein precursor  
Size: 715 amino acids; 79694 Da
Subcellular location: Secreted (Potential)
Caution: Although it belongs to the peptidase S1 family, it lacks essential His, Asp, and Ser residues of the
catalytic triad and is therefore predicted to lack peptidase activity
Sequence caution: Sequence=AAC35412.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites;
Secondary accessions: B7WPB1 Q13209
Alternative splicing: 2 isoforms:  Q2TV78-1   Q2TV78-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MST1L: NX_Q2TV78

MST1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001258662.1  
Human Recombinant Protein Products for MST1L: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

MST1L for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5/9 InterPro protein domains (see all 9):
 IPR001314 Peptidase_S1A
 IPR018056 Kringle_CS
 IPR001254 Peptidase_S1
 IPR024174 HGF_MST1
 IPR003609 Pan_app

Graphical View of Domain Structure for InterPro Entry Q2TV78

ProtoNet protein and cluster: Q2TV78

2 Blocks protein domains:
IPB000001 Kringle
IPB001254 Serine protease


UniProtKB/Swiss-Prot: MST1L_HUMAN, Q2TV78
Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily
Similarity: Contains 4 kringle domains
Similarity: Contains 1 PAN domain
Similarity: Contains 1 peptidase S1 domain


MST1L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for MST1L:
macrocyte stimulating factor 1,like sequence

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004252serine-type endopeptidase activity IEA--
     
MST1L for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MST1L

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--

MST1L for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MST1L

Search CenterWatch for drugs/clinical trials and news about MST1L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MST1L gene: 
NM_001271733.1  

Unigene Cluster for MST1L:

Macrophage stimulating 1-like
Hs.655432  [show with all ESTs]
Unigene Representative Sequence: NM_001271733
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000455405 ENST00000442552 ENST00000544155 ENST00000545160 ENST00000389184(uc001azp.4)

miRNA
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Additional mRNA sequence: 

AF116647.1 AY192149.1 

19 DOTS entries:

DT.92460586  DT.121461903  DT.450910  DT.121461952  DT.95171773  DT.97841671  DT.121346651  DT.75103381 
DT.92441951  DT.95365621  DT.120882109  DT.121346632  DT.92460594  DT.95171769  DT.95171775  DT.100674403 
DT.100772881  DT.121461845  DT.121461960 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MST1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MST1L Expression
About this image


Genevestigator expression for MST1L

SOURCE GeneReport for Unigene cluster: Hs.655432
    SABiosciences Custom PCR Arrays for MST1L
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for MST1L (if available)
TreeFam Gene Tree for MST1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MST1L gene
18/25 SIMAP similar genes for MST1L using alignment to 1 protein entry:     MST1L_HUMAN(see all similar genes):
MST1    LPAL2    DKFZp779M0222    APOA    PRSS1    TMPRSS5
PLG    CELA3A    TRY6    CELA3B    CMA1    CTRB2
KLK9    PRSS3    PRSS2    CELA1    CELA2A    CTRB1

MST1L for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for MST1L
PGOHUM00000259553


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/301 SNPs in MST1L are shown (see all 301)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs771922791,2
F--17080697(+) TGGATA/GTTTAG 1 -- ds50011Minor allele frequency- G:0.33NA 6
rs770699391,2
C,F--17080727(+) AACACA/GGATGA 1 -- ds50012Minor allele frequency- G:0.37NA 8
rs1158459031,2
C--17081018(+) TATAAC/TCTTAC 1 -- ds50010--------
rs1484286981,2
C--17081047(+) TCTAA-/TATTTT 1 -- ds50010--------
rs2010644741,2
C--17081097(+) AAGCCC/TTCTCA 1 -- ds50010--------
rs1998023121,2
C--17081149(+) AATCAC/GGAGCT 1 -- ut310--------
rs3724343641,2
C--17081171(+) TTCTGC/TTCTCT 1 -- ut310--------
rs712382501,2
C--17081322(+) TCACAC/TCACCA 1 -- ut311Minor allele frequency- T:0.50NA 2
rs712382511,2
--17081394(+) CAAACT/AAGAAA 1 -- ut311Minor allele frequency- A:0.50NA 2
rs26105941,2
C--17081430(-) AACCTG/TGCTAG 1 -- ut31 ese31Minor allele frequency- T:0.50NA 2

HapMap Linkage Disequilibrium report for MST1L (17081401 - 17096732 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MST1L: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MST1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with MST1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure of the human D1F15S1A locus: a chromosome 1 locus with 97 percent identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein. (PubMed id 10728827)1, 2, 3 Degen S.J....Carritt B. (1998)
  2. The GENCODE pseudogene resource. (PubMed id 22951037)1 Pei B....Gerstein M.B. (2012)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
  4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  5. Multiple MSP pseudogenes in a local repeat cluster on 1p36.2: An expanding genomic graveyard? (PubMed id 10585770)1 van der Drift P....Versteeg R. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 11223 HGNC: 7390 Ensembl:ENSG00000186715 euGenes: HUgn11223 ECgene: MST1L
H-InvDB: MST1L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MST1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MST1L gene:
Search GeneIP for patents involving MST1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1L
 Browse SwitchGear 3'UTR luciferase reporter plasmids for MST1L
 Browse SwitchGear Promoter luciferase reporter plasmids for MST1L
 Search ThermoFisher Antibodies for MST1L
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MST1L
 inGenious Targeting Laboratory - Custom generated mouse model solutions for MST1L
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MST1L
Customized:
 lentivirus for stable overexpression of MST1L
 lentivirus expression plasmids for stable overexpression of MST1L
 adenovirus for overexpression of MST1L
 Search LSBio for Antibodies for MST1L
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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