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MST1L Gene

pseudogene   GIFtS: 27
GCID: GC01M017083

Macrophage Stimulating 1-Like

(Previous names: macrophage stimulating, pseudogene 7, macrophage stimulating,...)
(Previous symbols: MSTP7, MSTP9, MST1P9)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Macrophage Stimulating 1-Like1 2     BRF-12 3
MST1P91 2 3     D1F15S1A2 3
MSTP91 2 3     MSPL-72
MSTP71 2     MSPL72
Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) Pseudogene 91 2     brain-rescue-factor-12
Macrophage Stimulating, Pseudogene 71 2     Putative Macrophage Stimulating 1-Like Protein2
Macrophage Stimulating, Pseudogene 91 2     Putative Macrophage-Stimulating Protein MSTP92
Brain Rescue Factor 12 3     Hepatocyte Growth Factor-Like Protein Homolog3

External Ids:    HGNC: 73901   Entrez Gene: 112232   Ensembl: ENSG000001867157   UniProtKB: Q2TV783   
ORGUL members:         

Export aliases for MST1L gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MST1L Gene:
MST1L (macrophage stimulating 1-like) is a pseudogene, and is affiliated with the lncRNA class. GO annotations related to this gene include serine-type endopeptidase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MST1L
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MST1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.33

MST1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M017083:  view genomic region     (about GC identifiers)

Start:
17,081,401 bp from pter      End:
17,096,732 bp from pter
Size:
15,332 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MST1L

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MST1L_HUMAN, Q2TV78 (See protein sequence)
Recommended Name: Putative macrophage stimulating 1-like protein precursor  
Size: 715 amino acids; 79694 Da
Caution: Although it belongs to the peptidase S1 family, it lacks essential His, Asp, and Ser residues of the
catalytic triad and is therefore predicted to lack peptidase activity
Sequence caution: Sequence=AAC35412.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites;
Secondary accessions: B7WPB1 Q13209
Alternative splicing: 2 isoforms:  Q2TV78-1   Q2TV78-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MST1L: NX_Q2TV78

Explore proteomics data for MST1L at MOPED


See MST1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001258662.1  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 9):
 IPR001314 Peptidase_S1A
 IPR018056 Kringle_CS
 IPR001254 Peptidase_S1
 IPR024174 HGF_MST1
 IPR003609 Pan_app

Graphical View of Domain Structure for InterPro Entry Q2TV78

ProtoNet protein and cluster: Q2TV78

2 Blocks protein domains:
IPB000001 Kringle
IPB001254 Serine protease


UniProtKB/Swiss-Prot: MST1L_HUMAN, Q2TV78
Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily
Similarity: Contains 4 kringle domains
Similarity: Contains 1 PAN domain
Similarity: Contains 1 peptidase S1 domain


Find genes that share domains with MST1L           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for MST1L:
macrocyte stimulating factor 1,like sequence

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004252serine-type endopeptidase activity IEA--
     
Find genes that share ontologies with MST1L           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MST1L_HUMAN, Q2TV78: Secreted (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with MST1L           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for MST1L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for MST1L



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MST1L gene: 
NM_001271733.1  

Unigene Cluster for MST1L:

Macrophage stimulating 1-like
Hs.655432  [show with all ESTs]
Unigene Representative Sequence: NM_001271733
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000455405 ENST00000442552 ENST00000544155 ENST00000545160 ENST00000389184(uc001azp.4)

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Additional mRNA sequence: 

AF116647.1 AY192149.1 

19 DOTS entries:

DT.92460586  DT.121461903  DT.450910  DT.121461952  DT.95171773  DT.97841671  DT.121346651  DT.75103381 
DT.92441951  DT.95365621  DT.120882109  DT.121346632  DT.92460594  DT.95171769  DT.95171775  DT.100674403 
DT.100772881  DT.121461845  DT.121461960 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MST1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MST1L Expression
About this image

MST1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MST1L Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.655432
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for MST1L (if available)
TreeFam Gene Tree for MST1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MST1L gene
Selected SIMAP similar genes for MST1L using alignment to 1 protein entry:     MST1L_HUMAN(see all similar genes):
MST1    LPAL2    DKFZp779M0222    APOA    PRSS1    TMPRSS5
PLG    CELA3A    CELA3B    CMA1    CTRB2    KLK9
PRSS3    PRSS2    CELA1    CELA2A    CTRB1    ELA3A

Find genes that share paralogs with MST1L           About GenesLikeMe


1 Pseudogenes.org Pseudogene for MST1L
PGOHUM00000259553


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MST1L (see all 301)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs771922791,2
F--17080697(+) TGGATA/GTTTAG 1 -- ds50011Minor allele frequency- G:0.33NA 6
rs770699391,2
C,F--17080727(+) AACACA/GGATGA 1 -- ds50012Minor allele frequency- G:0.37NA 8
rs1158459031,2
C--17081018(+) TATAAC/TCTTAC 1 -- ds50010--------
rs1484286981,2
C--17081047(+) TCTAA-/TATTTT 1 -- ds50010--------
rs2010644741,2
C--17081097(+) AAGCCC/TTCTCA 1 -- ds50010--------
rs1998023121,2
C--17081149(+) AATCAC/GGAGCT 1 -- ut310--------
rs3724343641,2
C--17081171(+) TTCTGC/TTCTCT 1 -- ut310--------
rs712382501,2
C--17081322(+) TCACAC/TCACCA 1 -- ut311Minor allele frequency- T:0.50NA 2
rs712382511,2
--17081394(+) CAAACT/AAGAAA 1 -- ut311Minor allele frequency- A:0.50NA 2
rs26105941,2
C--17081430(-) AACCTG/TGCTAG 1 -- ut31 ese31Minor allele frequency- T:0.50NA 2

HapMap Linkage Disequilibrium report for MST1L (17081401 - 17096732 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MST1L: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MST1L
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MST1L gene integrated from 10 sources:
(articles sorted by number of sources associating them with MST1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure of the human D1F15S1A locus: a chromosome 1 locus with 97 percent identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein. (PubMed id 10728827)1, 2, 3 Degen S.J....Carritt B. (DNA Seq. 1998)
  2. The GENCODE pseudogene resource. (PubMed id 22951037)1 Pei B....Gerstein M.B. (Genome Biol. 2012)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
  4. Multiple MSP pseudogenes in a local repeat cluster on 1p36.2: An expanding genomic graveyard? (PubMed id 10585770)1 van der Drift P....Versteeg R. (Genomics 1999)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11223 HGNC: 7390 Ensembl:ENSG00000186715 euGenes: HUgn11223 ECgene: MST1L
H-InvDB: MST1L

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MST1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MST1L gene:
Search GeneIP for patents involving MST1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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