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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MST1 Gene

protein-coding   GIFtS: 61
GCID: GC03M049696

macrophage stimulating 1 (hepatocyte growth factor-like)


(Previous symbols: D3F15S2, HGFL, DNF15S2)
 Explore 27 diseases affiliated with
MST1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MST1    

Aliases
for MST1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)1 2     Macrophage-Stimulating Protein2 3
HGFL1 2 3 5     Hepatocyte Growth Factor-Like Protein2
D3F15S21 2 3     Hepatocyte Growth Factor-Like Protein Homolog2
DNF15S21 2 3     Macrophage Stimulatory Protein3
MSP1 2 3     EC 3.4.218
NF15S21 2     

External Ids:    HGNC: 73801   Entrez Gene: 44852   Ensembl: ENSG000001735317   OMIM: 1424085   UniProtKB: P269273   

Export aliases for MST1 gene to outside databases

Previous GC identifers: GC03P046385 GC03P048678 GC03M049575 GC03M049681 GC03M049683


Summaries
for MST1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MST1:
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in
hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any
proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary
motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta
chain bridged by disulfide bonds. (provided by RefSeq, Jan 2010)

Gene Wiki entry for MST1


Genomic Views
for MST1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MST1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   E2F-2   E2F   E2F-1   SEF-1 (1)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MST1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MST1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

MST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049696:  view genomic region     (about GC identifiers)

Start:
 49,721,380 bp from pter      End:
 49,726,934 bp from pter
Size:
 5,555 bases      Orientation:
 minus strand

Proteins
for MST1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HGFL_HUMAN, P26927 (See protein sequence)
Recommended Name: Hepatocyte growth factor-like protein precursor  
Size: 711 amino acids; 80320 Da
Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond
Subcellular location: Secreted
Caution: Although related to peptidase S1 family, the active site residues characteristic of serine proteases appear to
be absent from this protein, which may therefore lack protease activity
1 PDB 3D structure from and Proteopedia for MST1:
2ASU (3D)    
Secondary accessions: A6NLA3 A8MSX3 Q13350 Q14870 Q6GTN4

Explore the universe of human proteins at neXtProt for MST1: NX_P26927

Post-translational modifications:

  • Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P26927

    • 4 DME Specific Peptides for MST1 (P26927)
     NYCRNPD  CRNPDGD  HFCGGSL  PWCYTTDP 

    MST1 Protein expression data from MOPED and PaxDb:    About this image 
    MST1 Protein Expression
    REFSEQ proteins: NP_066278.3  
    ENSEMBL proteins: 
     ENSP00000394756   ENSP00000414287   ENSP00000387988   ENSP00000411117   ENSP00000373234  
     ENSP00000437535  

    Human Recombinant Protein Products for MST1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MST1 (MSP/MST1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MST1
    OriGene Custom Protein Services for MST1 
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    Novus Biologicals MST1 Proteins
    Novus Biologicals MST1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MST1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    MST1 for ontologies           About GeneDecksing



    MST1 Antibody Products: 
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    ThermoFisher Antibodies for MST1

    Assay Products for MST1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript MST1-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MST1

    Protein Domains /
    Families
    for MST1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MST1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR001314 Peptidase_S1A
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR024174 HGF_MST1
     IPR003609 Pan_app

    Graphical View of Domain Structure for InterPro Entry P26927

    ProtoNet protein and cluster: P26927

    5 Blocks protein families:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB003014 N/apple PAN
    IPB003609 Apple-like


    UniProtKB/Swiss-Prot: HGFL_HUMAN, P26927
    Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily
    Similarity: Contains 4 kringle domains
    Similarity: Contains 1 PAN domain
    Similarity: Contains 1 peptidase S1 domain


    Function
    for MST1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:
         Genatlas biochemistry entry for MST1:
    macrophage stimulating,protein 1,paralog to HGF

         Enzyme Number (IUBMB): EC 3.4.212

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004252serine-type endopeptidase activity IEA--
         
    MST1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MST1:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mst1):
     digestive/alimentary  growth/size  hematopoietic system  immune system  liver/biliary system 

    MST1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Mst1tm1Jab for MST1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MST1 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MST1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MST1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MST1:
    hsa-miR-654-3p hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MST1 (see all 7)
    OriGene shRNA RFP: MST1
    OriGene siRNA: MST1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MST1
    Sirion Biotech Custom design and validation of potent shRNA sequences against MST1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MST1
    Sirion Biotech Customized adenovirus for overexpression of MST1 
    Sirion Biotech Customized adenovirus for potent knockdown of MST1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MST1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MST1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MST1 (NM_020998)
    Sino Biological Human cDNA Clone for MST1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MST1 

    Cell Line
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    Search LifeMap BioReagents cell lines for MST1
    Sirion Biotech Customized stable knockdown cell line services for MST1 
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    Sirion Biotech Customized stable overexpressing cell line services for MST1
    Sirion Biotech Customized inducible overexpressing cell line services for MST1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1


    Pathways & Interactions
    for MST1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    2MSP-RON Signaling
    		MSP-RON Signaling1.00
    3FoxO family signaling
    		FoxO family signaling1.00
    4a6b1 and a6b4 Integrin signaling
    		a6b1 and a6b4 Integrin signaling1.00
    5amb2 Integrin signaling
    		amb2 Integrin signaling1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MST1
        MSP-RON Signaling

    5 BioSystems Pathways for MST1 
        Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    amb2 Integrin signaling
    FoxO family signaling
    a6b1 and a6b4 Integrin signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MST1

    5/6 Interacting proteins for MST1 (P269272, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOB1BQ7L9L42, 3MINT-4787512 I2D: score=1 
    KLKB1P039523I2D: score=1 
    MOB1AQ9H8S93I2D: score=1 
    MST1RQ049123I2D: score=1 
    SERPINA3P010113I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0008150biological_process ND--

    MST1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MST1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MST1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MST1
    10 Novoseek chemical compound relationships for MST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 70.8 89 7732008 (4), 10336478 (4), 9533936 (3), 12270548 (2) (see all 40)
    serine 42.1 15 11170010 (3), 14505491 (2), 8188657 (1), 9334391 (1) (see all 9)
    wortmannin 41.3 2 14505491 (2)
    n-formylmethionyl-leucylphenylalanine 32.9 1 16633352 (1)
    chloramphenicol 3.27 1 8621550 (1)
    fibrinogen 0 2 15845495 (1)
    nitric oxide 0 6 7514598 (4)
    threonine 0 2 17046291 (1), 14505491 (1)
    superoxide 0 6 11704649 (2), 16633352 (1)
    vegf 0 4 8695717 (2), 10211995 (1)

    Search CenterWatch for drugs/clinical trials and news about MST1 / HGFL 

    Transcripts
    for MST1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MST1 gene: 
    NM_020998.3  

    Unigene Clusters for MST1:

    Macrophage stimulating 1 (hepatocyte growth factor-like)
    Hs.349110  [show with all ESTs], Hs.512587  [show with all ESTs]
    Unigene Representative Sequences: BC044862, NM_020998
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000448220 ENST00000449682(uc003cxg.3 uc011bcu.1) ENST00000479115
    ENST00000492329 ENST00000428801 ENST00000488350(uc011bcs.1 uc010hkx.2 uc011bct.1)
    ENST00000493836 ENST00000484144 ENST00000481930 ENST00000484269 ENST00000498021
    ENST00000497359 ENST00000480268 ENST00000494809 ENST00000468847 ENST00000489007
    ENST00000484673 ENST00000432076

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MST1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MST1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MST1:
    hsa-miR-654-3p hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MST1 (see all 7)
    OriGene shRNA RFP: MST1
    OriGene siRNA: MST1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MST1
    Sirion Biotech Custom design and validation of potent shRNA sequences against MST1 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MST1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MST1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MST1 (NM_020998)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MST1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MST1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1

    Additional cDNA sequence: 

    AK222893.1 AK294324.1 AK296192.1 AK309567.1 BC048330.1 DQ786296.1 L11924.1 M74178.1 

    24/32 DOTS entries (see all 32):

    DT.95124346  DT.92441951  DT.121346651  DT.97841671  DT.100835425  DT.95171773  DT.121346669  DT.86842858 
    DT.100788840  DT.120904067  DT.121346647  DT.92460581  DT.120904373  DT.100775661  DT.450910  DT.121346632 
    DT.121461952  DT.92460594  DT.95365621  DT.100772881  DT.100804395  DT.121461903  DT.92460586  DT.95171772 

    24/107 AceView cDNA sequences (see all 107):

    CB164037 BE504691 BU631709 CB161840 BX106683 BE552280 BU687849 CK429469 
    AV682730 CD512889 AW024182 AL705354 AV689796 BE393397 H57229 CB146573 
    BX440374 AV685020 BM672747 CD171687 BX494581 BI764696 NM_020998 H57153 

    GeneLoc Exon Structure


    Expression
    for MST1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACTGGGTT
    MST1 Expression
    About this image

    MST1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverHepatic MesenchymeMesothelial CellsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MST1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MST1

    SOURCE GeneReport for Unigene clusters: Hs.349110 Hs.512587
        SABiosciences Expression via Pathway-Focused PCR Array including MST1: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1

    Orthologs
    for MST1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MST1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MST11 macrophage stimulating 1 (hepatocyte growth factor-like) 66.95(n)
    63.53(a)    		   396135  NM_205213.1  NP_990544.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 62(a)
    		 1 → many
    		 2(149768915-149804621)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC540162 similar to macrophage stimulating 1 (hepatocyte growth more 74.88(n)    BC044008.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mst12 macrophage stimulating 1 (hepatocyte growth factor-like) 75.08(n)   259260  AF370035.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 10(a)
    		 possible ortholog
    		 GroupUn.841(30640-42833)


    ENSEMBL Gene Tree for MST1 (if available)
    TreeFam Gene Tree for MST1 (if available) 

    Paralogs
    for MST1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MST1 gene
    KREMEN12  KREMEN22  PLAT2  PLG2  HGFAC2  LPA2  PLAU2  HABP22  
    F122  MST1L2  HGF2  
    18/41 SIMAP similar genes for MST1 using alignment to 7 protein entries:     HGFL_HUMAN (see all proteins) (see all similar genes):
    MST1L    HGF    LPAL2    APOA    DKFZp779M0222    PLG
    PRSS1    KLKB1    CELA3A    TRY6    CMA1    CELA1
    CELA3B    PRSS2    PRSS3    TMPRSS4    TMPRSS5    TRY8

    MST1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MST1
    PGOHUM00000244621


    Genomic Variants
    for MST1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/254 NCBI SNPs in MST1 are shown (see all 254)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2011392861,2
    		C,Fother49723916(+) GACCCT/GTAGAT 1 -- spa11Minor allele frequency- G:0.01EU 723
    rs10573631,2
    		--49721448(-) CTTGAT/CGCCAT 1 -- ut312Minor allele frequency- C:0.00NA 4
    rs31979991,2
    		C,F,H--49721532(-) GGTCCC/TGCTGG 2 R C mis1 ese324Minor allele frequency- T:0.25MN NS EA NA WA EU 8447
    rs10573191,2
    		C,F--49721561(-) AATTAT/GAATCC 2 /R /I mis11Minor allele frequency- G:0.00EU 1047
    rs1382381011,2
    		C--49721606(+) CAAGTG/AGGCCC 2 /P /L mis11Minor allele frequency- A:0.00NA 4476
    rs2014281131,2
    		F--49721653(+) GCCCCG/AGGCCA 1 -- int11Minor allele frequency- A:0.01EU 737
    rs1931648661,2
    		C--49721773(+) CAACAA/GTCCCT 2 L syn10--------
    rs130857911,2
    		C,F,H--49721798(+) CTCTCC/ACGCAC 2 /R syn1 ese314Minor allele frequency- A:0.28NS EA NA WA EU 6583
    rs1112608251,2
    		C,F--49721805(+) GCACAC/TGTCCT 2 H R mis12Minor allele frequency- T:0.00NA EU 1325
    rs1426900321,2
    		C,F--49721812(+) TCCTCG/AGTGCT 2 /R /* stg12Minor allele frequency- A:0.01NA EU 5859

    HapMap Linkage Disequilibrium report for MST1 (49721380 - 49726934 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for MST1
         6 CNVs: 91301 79762 91302 68370 79761 68371
    Human Gene Mutation Database (HGMD): MST1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MST1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MST1 for disorders           About GeneDecksing

    OMIM gene information: 142408    OMIM disorders: --

    20/27 diseases for MST1 (see all 27):    About MalaCards
    hepatitis    b-cell lymphomas    ankylosing spondylitis    inflammatory bowel disease
    papillary thyroid carcinoma    multiple sclerosis    ulcerative colitis    spondylitis
    bronchiectasis    hereditary pancreatitis    thyroid carcinoma    cholangitis
    pancreatic cancer    crohn's disease    sarcoidosis    breast cancer
    pancreatitis    thyroiditis    endometriosis    colon cancer

    10/12 Novoseek disease relationships for MST1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 33.7 5 17456594 (3), 15827676 (1), 8950984 (1)
    lung tumor 25.1 2 9533936 (2)
    tumors 24.9 16 9533936 (2), 15827676 (1), 17456594 (1), 18726519 (1) (see all 10)
    pancreatic cancer 21.1 5 17616662 (3), 17311308 (1)
    cancer 11.9 3 16279944 (1), 16170349 (1), 19040718 (1)
    primary tumor 3.25 1 9533936 (1)
    inflammation 0.082 1 8157975 (1)
    carcinoma 0.0404 2 9533936 (2)
    necrosis 0 2 16633352 (1), 15929040 (1)
    cancer lung 0 1 9533936 (1)

    Human Genome Epidemiology (HuGE) Navigator: MST1 (14 documents)

    Export disorders for MST1 gene to outside databases

    Publications
    for MST1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MST1 gene, integrated from 9 sources (see all 162):
    (articles sorted by number of sources associating them with MST1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. (PubMed id 8393443)1, 2, 3, 9 Yoshimura T.... Leonard E.J. (1993)
    2. Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. (PubMed id 1827141)1, 2, 9 Skeel A....Leonard E.J. (1991)
    3. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. (PubMed id 21875933)1, 2 Ganesan R....Kirchhofer D. (2011)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. (PubMed id 1655021)1, 2 Han S.... Friezner Degen S.J. (1991)
    6. Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel. (PubMed id 2902784)1, 3 Gerber M.J....Smith D.I. (1988)
    7. Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells. (PubMed id 11856768)1, 9 Rampino T....Dal Canton A. (2002)
    8. Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. (PubMed id 9045873)1, 9 Sakamoto O....Suda T. (1997)
    9. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. (PubMed id 19079170)1, 9 Goyette P....Rioux J.D. (2008)
    10. Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein. (PubMed id 10068459)1, 9 Yoshikawa W....Leonard E.J. (1999)

    External Searches for MST1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing MST1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4485 HGNC: 7380 AceView: MST1 Ensembl:ENSG00000173531 euGenes: HUgn4485
    ECgene: MST1 H-InvDB: MST1

    Other Databases showing MST1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MST1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MST1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MST1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MST1 gene:
    Search GeneIP for patents involving MST1

    GeneCards and IP:
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