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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MST1 Gene

protein-coding   GIFtS: 60
GCID: GC03M049696

Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)


(Previous symbols: D3F15S2, HGFL, DNF15S2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)1 2     MSP2 3
HGFL1 2 3 5     NF15S22
D3F15S21 2 3     Hepatocyte Growth Factor-Like Protein2
DNF15S21 2 3     Macrophage Stimulatory Protein3
Hepatocyte Growth Factor-Like Protein Homolog1 2     EC 3.4.218
Macrophage-Stimulating Protein2 3     

External Ids:    HGNC: 73801   Entrez Gene: 44852   Ensembl: ENSG000001735317   OMIM: 1424085   UniProtKB: P269273   

Export aliases for MST1 gene to outside databases

Previous GC identifers: GC03P046385 GC03P048678 GC03M049575 GC03M049681 GC03M049683


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MST1 Gene:
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found
in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have
any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates
ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain
and a beta chain bridged by disulfide bonds. (provided by RefSeq, Jan 2010)

GeneCards Summary for MST1 Gene: 
MST1 (macrophage stimulating 1 (hepatocyte growth factor-like)) is a protein-coding gene. Diseases associated with MST1 include hereditary pancreatitis, and bronchiectasis. GO annotations related to this gene include molecular_function and serine-type endopeptidase activity. An important paralog of this gene is PLG.

Gene Wiki entry for MST1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MST1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   E2F-2   E2F   E2F-1   SEF-1 (1)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMST1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MST1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

MST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049696:  view genomic region     (about GC identifiers)

Start:
49,721,380 bp from pter      End:
49,726,934 bp from pter
Size:
5,555 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HGFL_HUMAN, P26927 (See protein sequence)
Recommended Name: Hepatocyte growth factor-like protein precursor  
Size: 711 amino acids; 80320 Da
Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond
Subcellular location: Secreted
Caution: Although related to peptidase S1 family, the active site residues characteristic of serine proteases
appear to be absent from this protein, which may therefore lack protease activity
1 PDB 3D structure from and Proteopedia for MST1:
2ASU (3D)    
Secondary accessions: A6NLA3 A8MSX3 Q13350 Q14870 Q6GTN4

Explore the universe of human proteins at neXtProt for MST1: NX_P26927

Explore proteomics data for MST1 at MOPED 

Post-translational modifications:

  • UniProtKB: Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26927

  • 4 DME Specific Peptides for MST1 (P26927)
     NYCRNPD  CRNPDGD  HFCGGSL  PWCYTTDP 

    MST1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MST1 Protein Expression
    REFSEQ proteins: NP_066278.3  
    ENSEMBL proteins: 
     ENSP00000394756   ENSP00000414287   ENSP00000373234   ENSP00000437535  

    Human Recombinant Protein Products for MST1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MST1
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    Novus Biologicals MST1 Proteins
    Novus Biologicals MST1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    MST1 for ontologies           About GeneDecksing



    MST1 Antibody Products: 
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    GenScript MST1-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR001314 Peptidase_S1A
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR024174 HGF_MST1
     IPR003609 Pan_app

    Graphical View of Domain Structure for InterPro Entry P26927

    ProtoNet protein and cluster: P26927

    5 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB003014 N/apple PAN
    IPB003609 Apple-like


    UniProtKB/Swiss-Prot: HGFL_HUMAN, P26927
    Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily
    Similarity: Contains 4 kringle domains
    Similarity: Contains 1 PAN domain
    Similarity: Contains 1 peptidase S1 domain


    MST1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for MST1:
    macrophage stimulating,protein 1,paralog to HGF

         Enzyme Number (IUBMB): EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    MST1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MST1:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mst1):
     digestive/alimentary  growth/size  hematopoietic system  immune system  liver/biliary system 

    MST1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mst1tm1Jab for MST1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MST1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MST1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MST1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MST1 

    miRNA
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    hsa-miR-654-3p hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MST1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1amb2 Integrin signaling
    amb2 Integrin signaling
    2a6b1 and a6b4 Integrin signaling
    a6b1 and a6b4 Integrin signaling
    3MSP-RON Signaling
    MSP-RON Signaling
    4FoxO family signaling
    FoxO family signaling
    5Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MST1
        MSP-RON Signaling

    4 BioSystems Pathways for MST1
        Integrated Pancreatic Cancer Pathway
    a6b1 and a6b4 Integrin signaling
    FoxO family signaling
    amb2 Integrin signaling



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MST1

    5/6 Interacting proteins for MST1 (P269272, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOB1BQ7L9L42, 3MINT-4787512 I2D: score=1 
    KLKB1P039523I2D: score=1 
    MOB1AQ9H8S93I2D: score=1 
    MST1RQ049123I2D: score=1 
    SERPINA3P010113I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007283spermatogenesis ----
    GO:0007566embryo implantation ----
    GO:0008150biological_process ND--
    GO:0030317sperm motility ----

    MST1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MST1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MST1 (HGFL)

    10 Novoseek inferred chemical compound relationships for MST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 70.8 89 7732008 (4), 10336478 (4), 9533936 (3), 12270548 (2) (see all 40)
    serine 42.1 15 11170010 (3), 14505491 (2), 8188657 (1), 9334391 (1) (see all 9)
    wortmannin 41.3 2 14505491 (2)
    n-formylmethionyl-leucylphenylalanine 32.9 1 16633352 (1)
    chloramphenicol 3.27 1 8621550 (1)
    fibrinogen 0 2 15845495 (1)
    nitric oxide 0 6 7514598 (4)
    threonine 0 2 17046291 (1), 14505491 (1)
    superoxide 0 6 11704649 (2), 16633352 (1)
    vegf 0 4 8695717 (2), 10211995 (1)

    Search CenterWatch for drugs/clinical trials and news about MST1 / HGFL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MST1 gene: 
    NM_020998.3  

    Unigene Clusters for MST1:

    Macrophage stimulating 1 (hepatocyte growth factor-like)
    Hs.349110  [show with all ESTs], Hs.512587  [show with all ESTs]
    Unigene Representative Sequences: BC044862, NM_020998
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000448220 ENST00000449682(uc003cxg.3 uc011bcu.1) ENST00000479115
    ENST00000492329 ENST00000488350(uc011bcs.1 uc010hkx.2 uc011bct.1)
    ENST00000493836 ENST00000484144 ENST00000481930 ENST00000484269 ENST00000498021
    ENST00000497359 ENST00000480268 ENST00000494809 ENST00000468847 ENST00000489007
    ENST00000484673 ENST00000492370 ENST00000494828
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MST1:
    hsa-miR-654-3p hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Clone
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    OriGene ORF clones in mouse, rat for MST1
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    GenScript: all cDNA clones in your preferred vector: MST1 (NM_020998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MST1
    Sirion Biotech Customized lentivirus for stable overexpression of MST1 
                         Customized lentivirus expression plasmids for stable overexpression of MST1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MST1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1

    Additional mRNA sequence: 

    AK222893.1 AK294324.1 AK296192.1 AK309567.1 BC048330.1 DQ786296.1 L11924.1 M74178.1 

    24/32 DOTS entries (see all 32):

    DT.95124346  DT.92441951  DT.121346651  DT.97841671  DT.100835425  DT.95171773  DT.121346669  DT.86842858 
    DT.100788840  DT.120904067  DT.121346647  DT.92460581  DT.120904373  DT.100775661  DT.450910  DT.121346632 
    DT.121461952  DT.92460594  DT.95365621  DT.100772881  DT.100804395  DT.121461903  DT.92460586  DT.95171772 

    24/107 AceView cDNA sequences (see all 107):

    AV682730 CB164037 CB161840 BE552280 BX106683 CK429469 BE504691 BU631709 
    BU687849 H57153 AW024182 CB141249 BI913479 CB961785 BM686514 AW629930 
    BI764696 CB146573 AV685020 BX426703 BU689368 H67898 BI913184 AI888066 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MST1 expression in normal human tissues (normalized intensities)      MST1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTGGGTT
    MST1 Expression
    About this image


    MST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Uterus (Reproductive System)
             cervix   
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Thyroid (Endocrine System)

    See MST1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MST1

    SOURCE GeneReport for Unigene clusters: Hs.349110 Hs.512587
        SABiosciences Expression via Pathway-Focused PCR Array including MST1: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MST1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MST1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mst11 , 5 macrophage stimulating 1 (hepatocyte growth factor-like)1, 5 81.4(n)1
    81.02(a)1
      9 (59.07 cM)5
    152351  NM_008243.31  NP_032269.31 
     1080804365 
    chicken
    (Gallus gallus)
    Aves MST11 macrophage stimulating 1 (hepatocyte growth factor-like) 66.95(n)
    63.53(a)
      396135  NM_205213.1  NP_990544.1 
    lizard
    (Anolis carolinensis)
    Reptilia MST16
    macrophage stimulating 1 (hepatocyte growth factor...
    63(a)
    1 ↔ 1
    2(149767493-149806532)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC540162 similar to macrophage stimulating 1 (hepatocyte growth more 74.88(n)    BC044008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mst12 macrophage stimulating 1 (hepatocyte growth factor-like) 75.08(n)   259260  AF370035.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mas6
    masquerade
    4(a)
    1 → many
    3L(4161666-4167464)


    ENSEMBL Gene Tree for MST1 (if available)
    TreeFam Gene Tree for MST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MST1 gene
    PLG2  PLAT2  HGFAC2  HABP22  LPA2  PLAU2  F122  HGF2  
    18/34 SIMAP similar genes for MST1 using alignment to 5 protein entries:     HGFL_HUMAN (see all proteins) (see all similar genes):
    MST1L    LPAL2    APOA    DKFZp779M0222    HGF    PRSS1
    KLKB1    PLG    CELA3A    TRY6    CMA1    CELA1
    CELA3B    PRSS2    PRSS3    TMPRSS4    TMPRSS5    TRY8

    MST1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MST1
    PGOHUM00000244621


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/204 SNPs in MST1 are shown (see all 204)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011392861,2
    C,Funtested149723916(+) GACCCT/GTAGAT 1 -- spa11Minor allele frequency- G:0.01EU 723
    VAR_0145694
    ----see VAR_0145692 E K mis40--------
    VAR_0066324
    ----see VAR_0066322 C F mis40--------
    VAR_0066314
    ----see VAR_0066312 C Y mis40--------
    rs10573631,2
    --49721448(-) CTTGAT/CGCCAT 1 -- ut312Minor allele frequency- C:0.00NA 4
    rs31979991,2
    C,F,H--49721532(-) GGTCCC/TGCTGG 2 R C mis1 ese324Minor allele frequency- T:0.25MN NS EA NA WA EU 8447
    rs10573191,2
    C,F--49721561(-) AATTAT/GAATCC 2 /R /I mis11Minor allele frequency- G:0.00EU 1047
    rs2014281131,2
    F--49721653(+) GCCCCG/AGGCCA 1 -- int11Minor allele frequency- A:0.01EU 737
    rs1931648661,2
    C--49721773(+) CAACAA/GTCCCT 2 L syn10--------
    rs130857911,2
    C,F,H--49721798(+) CTCTCC/ACGCAC 2 /R syn1 ese314Minor allele frequency- A:0.28NS EA NA WA EU 6583

    HapMap Linkage Disequilibrium report for MST1 (49721380 - 49726934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MST1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471425CNV Duplication19718026
    nsv820990CNV Duplication20802225
    nsv508217CNV Loss20534489
    nsv482080CNV Gain20164927
    nsv822077CNV Gain20364138
    esv28815CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): MST1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142408    OMIM disorders: --

    20/26 diseases for MST1 (see all 26):    About MalaCards
    hereditary pancreatitis    bronchiectasis    ulcerative colitis    pancreatic cancer
    papillary thyroid carcinoma    ankylosing spondylitis    crohn's disease    spondylitis
    hepatitis    sclerosing cholangitis    cholangitis    sarcoidosis
    peritonitis    endometriosis    inflammatory bowel disease    pancreatitis
    multiple sclerosis    b-cell lymphomas    hypoxia    thyroiditis


    MST1 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for MST1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 33.7 5 17456594 (3), 15827676 (1), 8950984 (1)
    lung tumor 25.1 2 9533936 (2)
    tumors 24.9 16 9533936 (2), 15827676 (1), 17456594 (1), 18726519 (1) (see all 10)
    pancreatic cancer 21.1 5 17616662 (3), 17311308 (1)
    cancer 11.9 3 16279944 (1), 16170349 (1), 19040718 (1)
    primary tumor 3.25 1 9533936 (1)
    inflammation 0.082 1 8157975 (1)
    carcinoma 0.0404 2 9533936 (2)
    necrosis 0 2 16633352 (1), 15929040 (1)
    cancer lung 0 1 9533936 (1)

    Genetic Association Database (GAD): MST1
    Human Genome Epidemiology (HuGE) Navigator: MST1 (14 documents)

    Export disorders for MST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MST1 gene, integrated from 9 sources (see all 168):
    (articles sorted by number of sources associating them with MST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. (PubMed id 8393443)1, 2, 3, 9 Yoshimura T.... Leonard E.J. (1993)
    2. Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. (PubMed id 1827141)1, 2, 9 Skeel A....Leonard E.J. (1991)
    3. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. (PubMed id 21875933)1, 2 Ganesan R....Kirchhofer D. (2011)
    4. Genome-wide association analysis in primary sclerosin g cholangitis identifies two non-HLA susceptibility loci. (PubMed id 21151127)1, 4 Melum E....Karlsen T.H. (2011)
    5. Genetic analysis in a Dutch study sample identifies m ore ulcerative colitis susceptibility loci and shows their additive role in dis ease risk. (PubMed id 19861958)1, 4 Festen E.A....Weersma R.K. (2010)
    6. Genome-wide association analysis in primary sclerosin g cholangitis. (PubMed id 19944697)1, 4 Karlsen T.H....Schreiber S. (2010)
    7. Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Weersma R.K. (2010)
    8. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (2010)
    9. Genome wide association (GWA) predictors of anti-TNFa lpha therapeutic responsiveness in pediatric inflammatory bowel disease. (PubMed id 20014019)1, 4 Dubinsky M.C....Rotter J.I. (2010)
    10. Analysis of 39 Crohn's disease risk loci in Swedish i nflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4485 HGNC: 7380 AceView: MST1 Ensembl:ENSG00000173531 euGenes: HUgn4485
    ECgene: MST1 H-InvDB: MST1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MST1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MST1 gene:
    Search GeneIP for patents involving MST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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