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MST1 Gene

protein-coding   GIFtS: 62
GCID: GC03M049730

Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)


(Previous symbols: D3F15S2, HGFL, DNF15S2)
  See MST1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)1 2     MSP2 3
HGFL1 2 3 5     NF15S22
D3F15S21 2 3     Hepatocyte Growth Factor-Like Protein2
DNF15S21 2 3     Macrophage Stimulatory Protein3
Hepatocyte Growth Factor-Like Protein Homolog1 2     EC 3.4.218
Macrophage-Stimulating Protein2 3     

External Ids:    HGNC: 73801   Entrez Gene: 44852   Ensembl: ENSG000001735317   OMIM: 1424085   UniProtKB: P269273   
ORGUL members:         

Export aliases for MST1 gene to outside databases

Previous GC identifers: GC03P046385 GC03P048678 GC03M049575 GC03M049681 GC03M049683 GC03M049696


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MST1 Gene:
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found
in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have
any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates
ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain
and a beta chain bridged by disulfide bonds. (provided by RefSeq, Jan 2010)

GeneCards Summary for MST1 Gene:
MST1 (macrophage stimulating 1 (hepatocyte growth factor-like)) is a protein-coding gene. Diseases associated with MST1 include primary sclerosing cholangitis, and t-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PLG.

Gene Wiki entry for MST1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MST1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   E2F-2   E2F   E2F-1   SEF-1 (1)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMST1 promoter sequence
   Search Chromatin IP Primers for MST1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

MST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MST1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049730:  view genomic region     (about GC identifiers)

Start:
49,721,380 bp from pter      End:
49,726,934 bp from pter
Size:
5,555 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HGFL_HUMAN, P26927 (See protein sequence)
Recommended Name: Hepatocyte growth factor-like protein precursor  
Size: 711 amino acids; 80320 Da
Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with
MST1R (via SEMA domain)
Caution: Although related to peptidase S1 family, the active site residues characteristic of serine proteases
appear to be absent from this protein, which may therefore lack protease activity
1 PDB 3D structure from and Proteopedia for MST1:
2ASU (3D)    
Secondary accessions: A6NLA3 A8MSX3 Q13350 Q14870 Q6GTN4

Explore the universe of human proteins at neXtProt for MST1: NX_P26927

Explore proteomics data for MST1 at MOPED

Post-translational modifications: 

  • Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains1
  • Glycosylation2 at Asn72, Asn296, Asn615
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for MST1 (P26927)
     NYCRNPD  CRNPDGD  HFCGGSL  PWCYTTDP 


    See MST1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066278.3  
    ENSEMBL proteins: 
     ENSP00000394756   ENSP00000414287   ENSP00000373234   ENSP00000437535  

    MST1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MST1 (MSP/MST1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MST1
    OriGene Custom MassSpec
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    GenScript Custom Purified and Recombinant Proteins Services for MST1
    Novus Biologicals MST1 Proteins
    Novus Biologicals MST1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MST1 

     
    antibodies-online proteins for MST1 (6 products) 

     
    antibodies-online peptides for MST1

    MST1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MST1 Antibodies
    Abcam antibodies for MST1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MST1
    antibodies-online antibodies for MST1 (55 products) 

    MST1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MST1
    R&D Systems ELISAs for MST1 (MSP/MST1)
    GenScript MST1-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MST1 
    antibodies-online kits for MST1 (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR001314 Peptidase_S1A
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR024174 HGF_MST1
     IPR003609 Pan_app

    Graphical View of Domain Structure for InterPro Entry P26927

    ProtoNet protein and cluster: P26927

    5 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB003014 N/apple PAN
    IPB003609 Apple-like


    UniProtKB/Swiss-Prot: HGFL_HUMAN, P26927
    Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily
    Similarity: Contains 4 kringle domains
    Similarity: Contains 1 PAN domain
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with MST1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for MST1:
    macrophage stimulating,protein 1,paralog to HGF

         Enzyme Number (IUBMB): EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    Find genes that share ontologies with MST1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MST1:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mst1):
     digestive/alimentary  growth/size/body  hematopoietic system  immune system  liver/biliary system 

    Find genes that share phenotypes with MST1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mst1tm1Jab for MST1

       genOway: Develop your customized and physiologically relevant rodent model for MST1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MST1:
    hsa-mir-34a-5p (MIRT025230)

    Block miRNA regulation of human, mouse, rat MST1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MST1:
    hsa-miR-654-3p hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MST1
    Predesigned siRNA for gene silencing in human, mouse, rat MST1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MST1

    Clone
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    OriGene clones in human, mouse for MST1 (see all 10)
    OriGene ORF clones in mouse, rat for MST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MST1 (NM_020998)
    Sino Biological Human cDNA Clone for MST1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MST1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MST1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MST1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HGFL_HUMAN, P26927: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with MST1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MST1 About    
    See pathways by source

    SuperPathContained pathways About
    1MSP-RON Signaling
    MSP-RON Signaling
    2Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    3FoxO family signaling
    FoxO family signaling
    4amb2 Integrin signaling
    amb2 Integrin signaling
    5a6b1 and a6b4 Integrin signaling
    a6b1 and a6b4 Integrin signaling

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MST1
        MSP-RON Signaling

    4 BioSystems Pathways for MST1
        Integrated Pancreatic Cancer Pathway
    a6b1 and a6b4 Integrin signaling
    amb2 Integrin signaling
    FoxO family signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including MST1: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MST1

    Selected Interacting proteins for MST1 (P269272, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOB1BQ7L9L42, 3MINT-4787512 I2D: score=1 
    KLKB1P039523I2D: score=1 
    MOB1AQ9H8S93I2D: score=1 
    MST1RQ049123I2D: score=1 
    SERPINA3P010113I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007283spermatogenesis ----
    GO:0007566embryo implantation ----
    GO:0008150biological_process ND--
    GO:0030317sperm motility ----

    Find genes that share ontologies with MST1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MST1 (HGFL)

    10 Novoseek inferred chemical compound relationships for MST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 70.8 89 7732008 (4), 10336478 (4), 9533936 (3), 12270548 (2) (see all 40)
    serine 42.1 15 11170010 (3), 14505491 (2), 8188657 (1), 9334391 (1) (see all 9)
    wortmannin 41.3 2 14505491 (2)
    n-formylmethionyl-leucylphenylalanine 32.9 1 16633352 (1)
    chloramphenicol 3.27 1 8621550 (1)
    fibrinogen 0 2 15845495 (1)
    nitric oxide 0 6 7514598 (4)
    threonine 0 2 17046291 (1), 14505491 (1)
    superoxide 0 6 11704649 (2), 16633352 (1)
    vegf 0 4 8695717 (2), 10211995 (1)



    Find genes that share compounds with MST1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MST1 gene: 
    NM_020998.3  

    Unigene Clusters for MST1:

    Macrophage stimulating 1 (hepatocyte growth factor-like)
    Hs.349110  [show with all ESTs], Hs.512587  [show with all ESTs]
    Unigene Representative Sequences: BC044862, NM_020998
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000448220 ENST00000449682(uc003cxg.3 uc011bcu.1) ENST00000479115
    ENST00000492329 ENST00000488350(uc011bcs.1 uc010hkx.2 uc011bct.1)
    ENST00000493836 ENST00000484144 ENST00000481930 ENST00000484269 ENST00000498021
    ENST00000497359 ENST00000480268 ENST00000494809 ENST00000468847 ENST00000489007
    ENST00000484673 ENST00000492370 ENST00000494828
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MST1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MST1:
    hsa-miR-654-3p hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MST1
    Predesigned siRNA for gene silencing in human, mouse, rat MST1
    Clone
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    OriGene clones in human, mouse for MST1 (see all 10)
    OriGene ORF clones in mouse, rat for MST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MST1 (NM_020998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MST1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MST1
    OriGene qSTAR qPCR primer pairs in human, mouse for MST1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MST1
      QuantiTect SYBR Green Assays in human, mouse, rat MST1
      QuantiFast Probe-based Assays in human, mouse, rat MST1

    Additional mRNA sequence: 

    AK222893.1 AK294324.1 AK296192.1 AK309567.1 BC048330.1 DQ786296.1 L11924.1 M74178.1 

    Selected DOTS entries (see all 32):

    DT.95124346  DT.92441951  DT.121346651  DT.97841671  DT.100835425  DT.95171773  DT.121346669  DT.86842858 
    DT.100788840  DT.120904067  DT.121346647  DT.92460581  DT.120904373  DT.100775661  DT.450910  DT.121346632 
    DT.121461952  DT.92460594  DT.95365621  DT.100772881  DT.100804395  DT.121461903  DT.92460586  DT.95171772 

    Selected AceView cDNA sequences (see all 107):

    CK429469 CB164037 BE552280 BE504691 AV682730 BX106683 CB161840 BU631709 
    BU687849 BI764696 AV685020 AL705354 BE221954 AI888066 AA927675 BV206261 
    H57153 BX439651 BU631061 BX494581 BM686514 BI913479 BC048330 BI826807 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTGGGTT
    MST1 Expression
    About this image


    MST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Thyroid (Endocrine System)
     
     Liver (Hepatobiliary System)
    MST1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MST1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.349110 Hs.512587
        Pathway & Disease-focused RT2 Profiler PCR Array including MST1: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MST1
    OriGene qSTAR qPCR primer pairs in human, mouse for MST1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MST1
    QuantiTect SYBR Green Assays in human, mouse, rat MST1
    QuantiFast Probe-based Assays in human, mouse, rat MST1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MST1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mst11 , 5 macrophage stimulating 1 (hepatocyte growth factor-like)1, 5 81.4(n)1
    81.02(a)1
      9 (59.07 cM)5
    152351  NM_008243.31  NP_032269.31 
     1080804365 
    chicken
    (Gallus gallus)
    Aves MST11 macrophage stimulating 1 (hepatocyte growth factor-like) 67.44(n)
    63.85(a)
      396135  NM_205213.1  NP_990544.1 
    lizard
    (Anolis carolinensis)
    Reptilia MST16
    macrophage stimulating 1 (hepatocyte growth factor...
    64(a)
    1 ↔ 1
    2(149767493-149806532)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC540162 similar to macrophage stimulating 1 (hepatocyte growth more 74.88(n)    BC044008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mst12 macrophage stimulating 1 (hepatocyte growth factor-like) 75.08(n)   259260  AF370035.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tequila6
    Tequila
    5(a)
    1 → many
    3L(9067745-9085231)
    worm
    (Caenorhabditis elegans)
    Secernentea svh-16
    Protein SVH-1 (svh-1) mRNA, complete cds
    14(a)
    1 → many
    IV(8206614-8213723) WBGene00006620


    ENSEMBL Gene Tree for MST1 (if available)
    TreeFam Gene Tree for MST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MST1 gene
    PLG2  PLAT2  HGFAC2  HABP22  LPA2  PLAU2  F122  HGF2  
    Selected SIMAP similar genes for MST1 using alignment to 5 protein entries:     HGFL_HUMAN (see all proteins) (see all similar genes):
    MST1L    LPAL2    APOA    DKFZp779M0222    HGF    PRSS1
    KLKB1    PLG    CELA3A    CMA1    PRSS3    CELA1
    CELA3B    PRSS2    TMPRSS4    TMPRSS5    TRY8    CTRB1

    Find genes that share paralogs with MST1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MST1
    PGOHUM00000244621


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MST1 (see all 205)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011392861,2
    C,Funtested149723916(+) GACCCT/GTAGAT 1 -- spa11Minor allele frequency- G:0.01EU 723
    rs10573631,2
    --49721448(-) CTTGAT/CGCCAT 1 -- ut312Minor allele frequency- C:0.00NA 4
    rs31979991,2,,4
    C,F,H--49721532(-) GGTCCC/TGCTGG 2 R C mis1 ese324Minor allele frequency- T:0.25MN NS EA NA WA EU 8447
    rs10573191,2
    C,F--49721561(-) AATTAT/GAATCC 2 /R /I mis11Minor allele frequency- G:0.00EU 1047
    rs2014281131,2
    F--49721653(+) GCCCCG/AGGCCA 1 -- int11Minor allele frequency- A:0.01EU 737
    rs1931648661,2
    C--49721773(+) CAACAA/GTCCCT 2 L syn10--------
    rs130857911,2
    C,F,H--49721798(+) CTCTCC/ACGCAC 2 /R syn1 ese314Minor allele frequency- A:0.28NS EA NA WA EU 6583
    rs1112608251,2
    C,F--49721805(+) GCACAC/TGTCCT 2 H R mis12Minor allele frequency- T:0.00NA EU 1325
    rs1426900321,2
    C,F--49721812(+) TCCTCG/AGTGCT 2 /R /* stg12Minor allele frequency- A:0.01NA EU 5859
    rs67828961,2
    A--49722133(+) AAGGCC/TCAGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MST1 (49721380 - 49726934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MST1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471425CNV Duplication19718026
    nsv820990CNV Duplication20802225
    nsv508217CNV Loss20534489
    nsv482080CNV Gain20164927
    nsv822077CNV Gain20364138
    esv28815CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): MST1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MST1
    DNA2.0 Custom Variant and Variant Library Synthesis for MST1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142408    OMIM disorders: --

    UniProtKB/Swiss-Prot: HGFL_HUMAN, P26927
  • Note=MST1 variant Cys-686 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing
    inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a
    variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD

  • 5 diseases for MST1:    
    About MalaCards
    primary sclerosing cholangitis    t-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations    sclerosing cholangitis    merkel cell carcinoma
    pancreatic cancer


    Find genes that share disorders with MST1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MST1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 33.7 5 17456594 (3), 15827676 (1), 8950984 (1)
    lung tumor 25.1 2 9533936 (2)
    tumors 24.9 16 9533936 (2), 15827676 (1), 17456594 (1), 18726519 (1) (see all 10)
    pancreatic cancer 21.1 5 17616662 (3), 17311308 (1)
    cancer 11.9 3 16279944 (1), 16170349 (1), 19040718 (1)
    primary tumor 3.25 1 9533936 (1)
    inflammation 0.082 1 8157975 (1)
    carcinoma 0.0404 2 9533936 (2)
    necrosis 0 2 16633352 (1), 15929040 (1)
    cancer lung 0 1 9533936 (1)

    Genetic Association Database (GAD): MST1
    Human Genome Epidemiology (HuGE) Navigator: MST1 (14 documents)

    Export disorders for MST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MST1 gene, integrated from 10 sources (see all 173):
    (articles sorted by number of sources associating them with MST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. (PubMed id 8393443)1, 2, 3, 9 Yoshimura T.... Leonard E.J. (J. Biol. Chem. 1993)
    2. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)1, 2, 4 McGovern D.P....Seielstad M. (Nat. Genet. 2010)
    3. Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. (PubMed id 1827141)1, 2, 9 Skeel A....Leonard E.J. (J. Exp. Med. 1991)
    4. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. (PubMed id 19079170)1, 2, 9 Goyette P....Rioux J.D. (Mucosal Immunol 2008)
    5. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. (PubMed id 21875933)1, 2 Ganesan R.... Kirchhofer D. (Mol. Cancer Res. 2011)
    6. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. (PubMed id 21151127)1, 4 Melum E....Karlsen T.H. (Nat. Genet. 2011)
    7. Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution. (PubMed id 22087277)1, 2 Gorlatova N....Herzberg O. (PLoS ONE 2011)
    8. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PubMed id 19861958)1, 4 Festen E.A....Weersma R.K. (Am. J. Gastroenterol. 2010)
    9. Genome-wide association analysis in primary sclerosing cholangitis. (PubMed id 19944697)1, 4 Karlsen T.H....Schreiber S. (Gastroenterology 2010)
    10. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4485 HGNC: 7380 AceView: MST1 Ensembl:ENSG00000173531 euGenes: HUgn4485
    ECgene: MST1 H-InvDB: MST1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MST1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MST1 gene:
    Search GeneIP for patents involving MST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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