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Aliases for MST1 Gene

Aliases for MST1 Gene

  • Macrophage Stimulating 1 2 3
  • Macrophage-Stimulating Protein 3 4
  • D3F15S2 3 4
  • DNF15S2 3 4
  • HGFL 3 4
  • MSP 3 4
  • Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) 3
  • Hepatocyte Growth Factor-Like Protein Homolog 3
  • Macrophage Stimulatory Protein 4
  • Hepatocyte Growth Factor-Like 2
  • EC 3.4.21 63
  • NF15S2 3

External Ids for MST1 Gene

Previous HGNC Symbols for MST1 Gene

  • D3F15S2
  • HGFL
  • DNF15S2

Previous GeneCards Identifiers for MST1 Gene

  • GC03P046385
  • GC03P048678
  • GC03M049575
  • GC03M049681
  • GC03M049696
  • GC03M049730

Summaries for MST1 Gene

Entrez Gene Summary for MST1 Gene

  • The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]

GeneCards Summary for MST1 Gene

MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include t-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations and cholangitis, primary sclerosing. Among its related pathways are amb2 Integrin signaling and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PLAT.

Gene Wiki entry for MST1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MST1 Gene

Genomics for MST1 Gene

Regulatory Elements for MST1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MST1 Gene

49,683,947 bp from pter
49,689,528 bp from pter
5,582 bases
Minus strand

Genomic View for MST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MST1 Gene

Proteins for MST1 Gene

  • Protein details for MST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatocyte growth factor-like protein
    Protein Accession:
    Secondary Accessions:
    • A6NLA3
    • A8MSX3
    • Q13350
    • Q14870
    • Q6GTN4

    Protein attributes for MST1 Gene

    711 amino acids
    Molecular mass:
    80320 Da
    Quaternary structure:
    • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).

    Three dimensional structures from OCA and Proteopedia for MST1 Gene

neXtProt entry for MST1 Gene

Proteomics data for MST1 Gene at MOPED

Selected DME Specific Peptides for MST1 Gene

Post-translational modifications for MST1 Gene

  • Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains
  • Glycosylation at Asn 72, Asn 296, and Asn 615
  • Modification sites at PhosphoSitePlus

Other Protein References for MST1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MST1 Gene

Suggested Antigen Peptide Sequences for MST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 kringle domains.
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
  • Contains 4 kringle domains.
  • Contains 1 PAN domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
genes like me logo Genes that share domains with MST1: view

No data available for Gene Families for MST1 Gene

Function for MST1 Gene

Molecular function for MST1 Gene

GENATLAS Biochemistry:
macrophage stimulating,protein 1,paralog to HGF

Enzyme Numbers (IUBMB) for MST1 Gene

Gene Ontology (GO) - Molecular Function for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004252 serine-type endopeptidase activity --
GO:0008236 NOT serine-type peptidase activity IBA --
genes like me logo Genes that share ontologies with MST1: view
genes like me logo Genes that share phenotypes with MST1: view

Animal Models for MST1 Gene

MGI Knock Outs for MST1:

miRNA for MST1 Gene

miRTarBase miRNAs that target MST1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MST1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MST1 Gene

Localization for MST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MST1 Gene


Subcellular locations from

Jensen Localization Image for MST1 Gene COMPARTMENTS Subcellular localization image for MST1 gene
Compartment Confidence
extracellular 5
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005773 vacuole --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MST1: view

Pathways & Interactions for MST1 Gene

genes like me logo Genes that share pathways with MST1: view

Pathways by source for MST1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • MAP Kinase (MAPK) Signaling Pathway in human,mouse,rat

SIGNOR curated interactions for MST1 Gene


Gene Ontology (GO) - Biological Process for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007283 spermatogenesis --
GO:0007566 embryo implantation --
GO:0008150 biological_process ND --
GO:0010628 positive regulation of gene expression --
genes like me logo Genes that share ontologies with MST1: view

Drugs & Compounds for MST1 Gene

(6) Drugs for MST1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved Pharma 6
Nitric Oxide Approved Pharma 540
Wortmannin Pharma PI3K inhibitor,selective and irreversible 0
serine Nutra 420
threonine Nutra 16

(4) Additional Compounds for MST1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
genes like me logo Genes that share compounds with MST1: view

Transcripts for MST1 Gene

Unigene Clusters for MST1 Gene

Macrophage stimulating 1 (hepatocyte growth factor-like):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MST1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MST1 Gene

No ASD Table

Relevant External Links for MST1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MST1 Gene

mRNA expression in normal human tissues for MST1 Gene

mRNA differential expression in normal tissues according to GTEx for MST1 Gene

This gene is overexpressed in Liver (x31.7).

Protein differential expression in normal tissues from HIPED for MST1 Gene

This gene is overexpressed in Serum (36.4), Plasma (19.4), and Synovial fluid (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MST1 Gene

SOURCE GeneReport for Unigene cluster for MST1 Gene Hs.349110

genes like me logo Genes that share expression patterns with MST1: view

Protein tissue co-expression partners for MST1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MST1 Gene

Orthologs for MST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MST1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MST1 35
  • 81.97 (n)
  • 82.68 (a)
MST1 36
  • 83 (a)
(Canis familiaris)
Mammalia MST1 35
  • 86.53 (n)
  • 88.69 (a)
MST1 36
  • 89 (a)
(Mus musculus)
Mammalia Mst1 35
  • 81.4 (n)
  • 81.02 (a)
Mst1 16
Mst1 36
  • 80 (a)
(Pan troglodytes)
Mammalia MST1 35
  • 99.4 (n)
  • 99.31 (a)
MST1 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Mst1 35
  • 80.83 (n)
  • 81.02 (a)
(Monodelphis domestica)
Mammalia MST1 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia MST1 36
  • 61 (a)
(Gallus gallus)
Aves MST1 35
  • 67.44 (n)
  • 63.85 (a)
MST1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia MST1 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mst1 35
  • 61.72 (n)
  • 60.99 (a)
Str.2230 35
African clawed frog
(Xenopus laevis)
Amphibia MGC54016 35
(Danio rerio)
Actinopterygii mst1 35
  • 59.82 (n)
  • 57.89 (a)
mst1 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10681 35
fruit fly
(Drosophila melanogaster)
Insecta Tequila 36
  • 5 (a)
(Caenorhabditis elegans)
Secernentea svh-1 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for MST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MST1 Gene

Gene Tree for MST1 (if available)
Gene Tree for MST1 (if available)

Paralogs for MST1 Gene

Paralogs for MST1 Gene Pseudogenes for MST1 Gene

genes like me logo Genes that share paralogs with MST1: view

Variants for MST1 Gene

Sequence variations from dbSNP and Humsavar for MST1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs750686671 -- 49,684,761(+) ACAAG(A/C)TGGGA reference, missense, downstream-variant-500B, utr-variant-3-prime, nc-transcript-variant
rs750648061 -- 49,686,643(+) CCCAA(A/G)GTTCC intron-variant
rs750641553 -- 49,686,768(+) ATTCC(A/G)GCAAT reference, missense, synonymous-codon, nc-transcript-variant
rs750568083 -- 49,685,700(+) CCTCC(A/C)GTTGT missense, reference, nc-transcript-variant
rs750408728 -- 49,684,637(+) CACAC(A/G)CTGGT reference, missense, downstream-variant-500B, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MST1 Gene

Variant ID Type Subtype PubMed ID
nsv508217 CNV Loss 20534489
nsv820990 CNV Duplication 20802225
esv28815 CNV Gain+Loss 19812545
nsv471425 CNV Duplication 19718026
nsv482080 CNV Gain 20164927
nsv822077 CNV Gain 20364138

Variation tolerance for MST1 Gene

Residual Variation Intolerance Score: 78.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MST1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MST1 Gene

Disorders for MST1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MST1 Gene - From: OMIM, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
t-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations
  • stk4 deficiency
cholangitis, primary sclerosing
  • sclerosing cholangitis
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
  • kartagener syndrome
- elite association
Search MST1 in MalaCards View complete list of genes associated with diseases


  • Note=MST1 variant Cys-689 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD. {ECO:0000269 PubMed:19079170, ECO:0000269 PubMed:20228799}.

Relevant External Links for MST1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MST1: view

No data available for Genatlas for MST1 Gene

Publications for MST1 Gene

  1. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. (PMID: 8393443) Yoshimura T. … Leonard E.J. (J. Biol. Chem. 1993) 2 23 67
  2. Inhibition of MSP-RON signaling pathway in cancer cells by a novel soluble form of RON comprising the entire sema sequence. (PMID: 20428780) Ma Q. … Wang M.H. (Int. J. Oncol. 2010) 23 67
  3. Recepteur d'origine nantais tyrosine kinase is a direct target of hypoxia-inducible factor-1alpha-mediated invasion of breast carcinoma cells. (PMID: 19307182) Thangasamy A. … Ammanamanchi S. (J. Biol. Chem. 2009) 23 67
  4. Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein. (PMID: 19456860) Kawaguchi M. … Kataoka H. (FEBS J. 2009) 23 67
  5. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. (PMID: 19720831) Chanda D. … Choi H.S. (J. Biol. Chem. 2009) 23 67

Products for MST1 Gene

Sources for MST1 Gene

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