Aliases for MST1 Gene
External Ids for MST1 Gene
Previous HGNC Symbols for MST1 Gene
Previous GeneCards Identifiers for MST1 Gene
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
GeneCards Summary for MST1 Gene
MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include cholangitis, primary sclerosing and t-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations. Among its related pathways are amb2 Integrin signaling and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PLAT.