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Aliases for MSS51 Gene

Aliases for MSS51 Gene

  • MSS51 Mitochondrial Translational Activator 2 3 5
  • Zinc Finger MYND Domain-Containing Protein 17 3 4
  • Zinc Finger, MYND-Type Containing 17 2 3
  • ZMYND17 3 4
  • MSS51 Mitochondrial Translational Activator Homolog (S. Cerevisiae) 2
  • MSS51 Mitochondrial Translational Activator Homolog 3
  • Putative Protein MSS51 Homolog, Mitochondrial 3
  • Zinc Finger, MYND Domain Containing 17 3

External Ids for MSS51 Gene

Previous HGNC Symbols for MSS51 Gene

  • ZMYND17

Previous GeneCards Identifiers for MSS51 Gene

  • GC10M075184

Summaries for MSS51 Gene

GeneCards Summary for MSS51 Gene

MSS51 (MSS51 Mitochondrial Translational Activator) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSS51 Gene

Genomics for MSS51 Gene

Regulatory Elements for MSS51 Gene

Enhancers for MSS51 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G073419 1 FANTOM5 ENCODE 2.1 +13.8 13793 0.4 JUN ZNF384 FOSL1 ZNF316 FOS NFE2 MAFK ZNF652 SMARCE1 MTA2 CFAP70 ENSG00000233144 RNU6-883P USP54 MSS51 RPL26P6 GC10P073416
GH10G073451 0.8 FANTOM5 0.4 -18.1 -18109 0.1 HDGF HDAC1 SAP130 TAF1 GTF2E2 SIN3A RBBP5 HBP1 POLR2A ZSCAN29 ENSG00000233144 MSS51 PPP3CB-AS1
GH10G073456 1 ENCODE 0.3 -22.8 -22817 0.1 PKNOX1 ATF1 ARNT E2F7 TCF12 ZNF766 CBX5 ELK1 GATA2 NCOA1 SYNPO2L USP54 RNU6-883P MSS51 PPP3CB-AS1
GH10G073433 0.4 ENCODE 0.7 0.0 -7 1.0 ATF1 GATA2 MSS51 PPP3CB-AS1
GH10G073493 1.1 ENCODE 0.2 -61.7 -61742 3.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A ZNF2 YY1 ZNF143 CFAP70 ECD AP3M1 ZSWIM8 RNU6-883P USP54 NUDT13 PPP3CB-AS1 MSS51
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MSS51 on UCSC Golden Path with GeneCards custom track

Genomic Location for MSS51 Gene

Chromosome:
10
Start:
73,423,579 bp from pter
End:
73,433,561 bp from pter
Size:
9,983 bases
Orientation:
Minus strand

Genomic View for MSS51 Gene

Genes around MSS51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSS51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSS51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSS51 Gene

Proteins for MSS51 Gene

  • Protein details for MSS51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VC12-MSS51_HUMAN
    Recommended name:
    Putative protein MSS51 homolog, mitochondrial
    Protein Accession:
    Q4VC12
    Secondary Accessions:
    • A6NGH6
    • Q2VP95
    • Q5F2H5
    • Q7Z3M9
    • Q8N8G0

    Protein attributes for MSS51 Gene

    Size:
    460 amino acids
    Molecular mass:
    51289 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSS51 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSS51 Gene

Post-translational modifications for MSS51 Gene

No Post-translational modifications

Other Protein References for MSS51 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSS51 Gene

Domains & Families for MSS51 Gene

Gene Families for MSS51 Gene

Protein Domains for MSS51 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MSS51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MSS51: view

No data available for UniProtKB/Swiss-Prot for MSS51 Gene

Function for MSS51 Gene

Gene Ontology (GO) - Molecular Function for MSS51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MSS51: view

Phenotypes for MSS51 Gene

genes like me logo Genes that share phenotypes with MSS51: view

Animal Model Products

miRNA for MSS51 Gene

miRTarBase miRNAs that target MSS51

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSS51 Gene

Localization for MSS51 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSS51 gene
Compartment Confidence
mitochondrion 3
nucleus 3
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MSS51 Gene

Pathways & Interactions for MSS51 Gene

SuperPathways for MSS51 Gene

No Data Available

Interacting Proteins for MSS51 Gene

Gene Ontology (GO) - Biological Process for MSS51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035176 social behavior IEP 21531385
genes like me logo Genes that share ontologies with MSS51: view

No data available for Pathways by source and SIGNOR curated interactions for MSS51 Gene

Drugs & Compounds for MSS51 Gene

No Compound Related Data Available

Transcripts for MSS51 Gene

mRNA/cDNA for MSS51 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MSS51 Gene

MSS51 mitochondrial translational activator:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSS51 Gene

No ASD Table

Relevant External Links for MSS51 Gene

GeneLoc Exon Structure for
MSS51
ECgene alternative splicing isoforms for
MSS51

Expression for MSS51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSS51 Gene

mRNA differential expression in normal tissues according to GTEx for MSS51 Gene

This gene is overexpressed in Muscle - Skeletal (x18.4).

NURSA nuclear receptor signaling pathways regulating expression of MSS51 Gene:

MSS51

SOURCE GeneReport for Unigene cluster for MSS51 Gene:

Hs.631823

Evidence on tissue expression from TISSUES for MSS51 Gene

  • Muscle(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MSS51: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSS51 Gene

Orthologs for MSS51 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSS51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYND17 34
  • 99.2 (n)
MSS51 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSS51 34 35
  • 88.26 (n)
cow
(Bos Taurus)
Mammalia ZMYND17 34
  • 87.67 (n)
MSS51 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mss51 34 16 35
  • 84.35 (n)
rat
(Rattus norvegicus)
Mammalia Mss51 34
  • 81.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MSS51 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSS51 34 35
  • 61.37 (n)
lizard
(Anolis carolinensis)
Reptilia MSS51 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496751 34
  • 57.39 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330275 34
  • 55.26 (n)
mss51 35
  • 48 (a)
OneToOne
Species where no ortholog for MSS51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSS51 Gene

ENSEMBL:
Gene Tree for MSS51 (if available)
TreeFam:
Gene Tree for MSS51 (if available)

Paralogs for MSS51 Gene

(1) SIMAP similar genes for MSS51 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MSS51: view

No data available for Paralogs for MSS51 Gene

Variants for MSS51 Gene

Sequence variations from dbSNP and Humsavar for MSS51 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000924322 -- 73,432,896(+) TGAGA(A/G)AAACA intron-variant
rs1000935773 -- 73,429,230(+) GTAAC(A/G)GTGAT intron-variant
rs1001323310 -- 73,428,232(+) TGGGA(A/G)CCACT reference, missense
rs1001679809 -- 73,434,802(+) AAAAA(C/T)CCTAA upstream-variant-2KB
rs1001832791 -- 73,432,089(+) GCTGG(A/G)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSS51 Gene

Variant ID Type Subtype PubMed ID
nsv831911 CNV loss 17160897

Variation tolerance for MSS51 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSS51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSS51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSS51 Gene

Disorders for MSS51 Gene

Relevant External Links for MSS51

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSS51

No disorders were found for MSS51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSS51 Gene

Publications for MSS51 Gene

  1. Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria. (PMID: 19710419) Perez-Martinez X. … Fox T.D. (Mol. Biol. Cell 2009) 2 3 64
  2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  3. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function. (PMID: 21531385) Liu C.M. … Hwu H.G. (Biol. Psychiatry 2011) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 64

Products for MSS51 Gene

Sources for MSS51 Gene

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