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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSRB3 Gene

protein-coding   GIFtS: 55
GCID: GC12P065672

methionine sulfoxide reductase B3

(Previous names: deafness, autosomal recessive 74 )
(Previous symbol: DFNB74)
 Explore 8 diseases affiliated with
MSRB3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MSRB3    

Aliases
for MSRB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Methionine Sulfoxide Reductase B31 2     Methionine-R-Sulfoxide Reductase B32
DFNB741 2 5     Methionine-R-Sulfoxide Reductase B3, Mitochondrial2
DKFZp686C11781     EC 1.8.4.-3
FLJ368661     MsrB33
Deafness, Autosomal Recessive 741     EC 1.8.4.128

External Ids:    HGNC: 273751   Entrez Gene: 2538272   Ensembl: ENSG000001740997   OMIM: 6137195   UniProtKB: Q8IXL73   

Export aliases for MSRB3 gene to outside databases

Previous GC identifers: GC12P063961 GC12P062724


Summaries
for MSRB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MSRB3:
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a
monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found
for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula.
(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential
for hearing




Genomic Views
for MSRB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSRB3 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   RORalpha2   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MSRB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSRB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3   Ensembl cytogenetic band:  12q14.3   HGNC cytogenetic band: 12q14.3

MSRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSRB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P065672:  view genomic region     (about GC identifiers)

Start:
 65,672,423 bp from pter      End:
 65,882,024 bp from pter
Size:
 209,602 bases      Orientation:
 plus strand

Proteins
for MSRB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7 (See protein sequence)
Recommended Name: Methionine-R-sulfoxide reductase B3 precursor  
Size: 192 amino acids; 20702 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer
Subcellular location: Isoform 1: Endoplasmic reticulum
Subcellular location: Isoform 2: Mitochondrion
Secondary accessions: B4DR19 B7ZAQ0 Q6UXS2
Alternative splicing: 2 isoforms:  Q8IXL7-1   Q8IXL7-2   (Has a transit peptide)

Explore the universe of human proteins at neXtProt for MSRB3: NX_Q8IXL7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IXL7

    • 4 DME Specific Peptides for MSRB3 (Q8IXL7)
     RYCINSA  CGAHLGH  GIYKCVVC  FDDGPRPTGKRYC 

    MSRB3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001026849.1  NP_001180389.1  NP_001180390.1  NP_932346.1  

    ENSEMBL proteins: 
     ENSP00000347324   ENSP00000312274   ENSP00000445051   ENSP00000437623   ENSP00000441650  
     ENSP00000440722   ENSP00000442620   ENSP00000445843   ENSP00000404903  

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    Uscn Proteins for MSRB3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA14699060
    GO:0005783endoplasmic reticulum IDA14699060


    MSRB3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MSRB3

    Protein Domains /
    Families
    for MSRB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MSRB3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002579 Met_Sox_Rdtase_MsrB
     IPR011057 Mss4-like

    Graphical View of Domain Structure for InterPro Entry Q8IXL7

    ProtoNet protein and cluster: Q8IXL7

    1 Blocks protein family: IPB002579 Protein of unknown function DUF25

    UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
    Similarity: Belongs to the MsrB Met sulfoxide reductase family


    Function
    for MSRB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
    Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential
    for hearing
    Catalytic activity: L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin

    Enzyme Numbers (IUBMB): EC 1.8.4.122 EC 1.8.4.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSRB3
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    hsa-miR-607 hsa-miR-300 hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a* hsa-miR-1304 hsa-miR-4325 hsa-miR-149
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for MSRB3

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008113peptide-methionine (S)-S-oxide reductase activity ----
    GO:0008270zinc ion binding IDA14699060
    GO:0033743peptide-methionine (R)-S-oxide reductase activity IDA14699060


    MSRB3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for MSRB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSRB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/12 Interacting proteins for MSRB3 (Q8IXL73 ENSP000003473244) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MSRAQ9UJ683, ENSP000003139214I2D: score=2 STRING: ENSP00000313921
    PSAT1Q9Y6173I2D: score=3 
    CNBPP626333I2D: score=1 
    DIAPH1O606103I2D: score=1 
    IDI1Q139073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030091protein repair IDA14699060


    MSRB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MSRB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSRB3

    1 HMDB Compound for MSRB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Methionine sulfoxideDL-Methionine sulfoxide (see all 7)62697-73-8--
    Search CenterWatch for drugs/clinical trials and news about MSRB3 

    Transcripts
    for MSRB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MSRB3 gene (4 alternative transcripts): 
    NM_001031679.2  NM_001193460.1  NM_001193461.1  NM_198080.3  

    Unigene Cluster for MSRB3:

    Methionine sulfoxide reductase B3
    Hs.339024  [show with all ESTs]
    Unigene Representative Sequence: NM_001193460
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355192 ENST00000308259(uc009zqp.3 uc001ssm.3 uc001ssn.3 uc021qzy.1)
    ENST00000541897 ENST00000538725 ENST00000540804 ENST00000535664 ENST00000541189
    ENST00000538045 ENST00000535239 ENST00000446731 ENST00000535143

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSRB3
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate MSRB3 (see all 92):
    hsa-miR-607 hsa-miR-300 hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a* hsa-miR-1304 hsa-miR-4325 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: MSRB3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSRB3 (see all 4)
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSRB3
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    Additional cDNA sequence: 

    AK094185.1 AK122602.1 AK126406.1 AK293084.1 AK299065.1 AK316365.1 AL833622.1 AY358229.1 
    BC040053.1 BX640871.1 BX648776.1 DQ786269.1 

    7 DOTS entries:

    DT.100660441  DT.95161747  DT.100754508  DT.91878202  DT.121123622  DT.121123677  DT.75115428 

    24/187 AceView cDNA sequences (see all 187):

    T60112 BQ233536 AI127981 AI381727 D62827 AA688008 CA392724 AA446357 
    CR600087 AI580978 BG939817 CF552834 AI095892 N34511 AI367033 BG939656 
    BQ941753 BQ009327 AA232570 BX503947 AA195322 BM696298 BQ017894 AL602613 

    GeneLoc Exon Structure


    Expression
    for MSRB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSRB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTTTCATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MSRB3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    BoneMembranous Facial BonesBone
    BoneThoracic RibBone
    BoneThoracic VertebraeBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium
    CD31, CD144 positive cells (Two-step protocol fo...)

    See MSRB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSRB3

    SOURCE GeneReport for Unigene cluster: Hs.339024

    UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:     
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    Orthologs
    for MSRB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MSRB3 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MSRB31 methionine sulfoxide reductase B3 84.06(n)
    85.87(a)    		   417833  NM_001199578.1  NP_001186507.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MSRB36
    SEPX16
    		 --
    		 73(a)
    38(a)
    		 1 ↔ 1
    possible ortholog
    		 5(50022857-50249880)
    GL343263.1(2010380-2010505)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc07g042 Transcribed sequence with weak similarity to protein more 78.24(n)    CF998052.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SelR1 CG6584-PA 53.29(n)
    51.97(a)    		   41309  NM_169369.2  NP_731523.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F44E2.66
    		 Uncharacterized protein F44E2.6
    		 38(a)
    		 possible ortholog
    		 III(8844412-8845135)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MSRB96
    MSRB56
    (see all 9)    		 peptide methionine sulfoxide reductase B5
    (see all 9)    		 43(a)
    42(a)
    (see all 9)    		 possible ortholog
    possible ortholog
    (see all 9)    		 4(11591116-11592238)
    4(2445794-2447086)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 peptide methionine sulfoxide reductase msrB, putat...
    peptide methionine sulfoxide reductase msrB, putat...
    (see all 3)    		 44(a)
    36(a)
    (see all 3)    		 possible ortholog
    1 ↔ 1
    (see all 3)    		 3(14008882-14012549)
    6(15717518-15720375)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria msrB6
    		 methionine sulfoxide reductase B
    		 45(a)
    		 1 ↔ 1
    		 Chromosome(1860040-1860453)


    ENSEMBL Gene Tree for MSRB3 (if available)
    TreeFam Gene Tree for MSRB3 (if available) 

    Paralogs
    for MSRB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSRB3 gene
    MSRB22  
    4 SIMAP similar genes for MSRB3 using alignment to 7 protein entries:     MSRB3_HUMAN (see all proteins):
    DKFZp686C1178    MSRB2    SEPX1    MSRB1

    MSRB3 for paralogs           About GeneDecksing



    Genomic Variants
    for MSRB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2710 NCBI SNPs in MSRB3 are shown (see all 2710)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796235901,2
    		C,--62722230(+) GCACAG/ATGTCT 3 -- us2k12Minor allele frequency- A:0.13NA 122
    rs12588941,2
    		H--62722385(-) TTACAA/CCCCAA 3 -- us2k14Minor allele frequency- C:0.00NS EA 412
    rs111757121,2
    		C,F,H,--62722784(+) TACTTT/CATCTG 4 -- us2k115Minor allele frequency- C:0.06NS EA NA WA 1634
    rs605586041,2
    		C,--62724919(+) CAGGCG/AGCAGG 4 -- int11Minor allele frequency- A:0.50WA 2
    rs1130110721,2
    		--62726539(+) GGGAGG/TATTGC 4 -- int11Minor allele frequency- T:0.50CSA 2
    rs123026521,2
    		C,A,--62727991(+) GCATCG/AAACAA 4 -- int12Minor allele frequency- A:0.14WA 120
    rs123160381,2
    		--62728049(+) GCAGTA/GACAGA 4 -- int10--------
    rs1112701601,2
    		C,--62729688(+) GCTTTC/TAATGC 4 -- int11Minor allele frequency- T:0.50NA 2
    rs1113962851,2
    		--62729875(+) TGAAGA/TCCTAA 4 -- int12Minor allele frequency- T:0.03CSA WA 120
    rs757791861,2
    		F,--62732100(+) TAGCCG/ATGACA 4 -- int11Minor allele frequency- A:0.04NA 120

    HapMap Linkage Disequilibrium report for MSRB3 (65672423 - 65882024 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MSRB3
         1 CNV: 35107
    Human Gene Mutation Database (HGMD): MSRB3

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    Disorders / Diseases
    for MSRB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MSRB3 for disorders           About GeneDecksing

    OMIM gene information: 613719   
    OMIM disorders: 613718  
    UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
  • Defects in MSRB3 are the cause of deafness autosomal recessive type 74 (DFNB74) [MIM:613718]. A form of
    • non-syndromic sensorineural deafness characterized by prelingual, bilateral, profound hearing loss. Sensorineural
    deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of
    the brain that receives sound information. Note=A nonsense mutation affecting exclusively mitochondrial isoform 2 is
    sufficient to produce hearing loss

    8 diseases for MSRB3:    About MalaCards
    deafness, autosomal recessive 74    tooth agenesis    lipoma    newcastle disease
    lipoma of colon    pneumonia    tuberculosis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for MSRB3:
    Lipoma of colon     Newcastle disease
    Human Genome Epidemiology (HuGE) Navigator: MSRB3 (1 document)

    Export disorders for MSRB3 gene to outside databases

    Publications
    for MSRB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSRB3 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with MSRB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. (PubMed id 21185009)1, 2, 3 Ahmed Z.M.... Riazuddin S. (2011)
    2. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. (PubMed id 14699060)1, 2, 9 Kim H.-Y. and Gladyshev V.N. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Differential expression of the antioxidant repair enz yme methionine sulfoxide reductase (MSRA and MSRB) in human skin. (PubMed id 19542914)1, 9 Taungjaruwinai W.M....Thiele J.J. (2009)
    6. Methionine sulfoxide reductase B in the endoplasmic re ticulum is critical for stress resistance and aging in Drosophila. (PubMed id 22310715)1 Lim D.H....Kim H.Y. (2012)
    7. Methionine sulfoxide reductase B3 protects from endopl asmic reticulum stress in Drosophila and in mammalian cells. (PubMed id 22405767)1 Kwak G.H....Kim H.Y. (2012)
    8. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. (PubMed id 22422452)1 Lee H....Fallin M.D. (2012)
    9. A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. (PubMed id 22832960)1 Service S.K....Freimer N.B. (2012)
    10. Common variants at 12q14 and 12q24 are associated with hippocampal volume. (PubMed id 22504421)1 Bis J.C....Seshadri S. (2012)

    External Searches for MSRB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing MSRB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 253827 HGNC: 27375 AceView: LOC253827 Ensembl:ENSG00000174099 euGenes: HUgn253827
    ECgene: MSRB3 H-InvDB: MSRB3

    Other Databases showing MSRB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MSRB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSRB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSRB3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MSRB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MSRB3 gene:
    Search GeneIP for patents involving MSRB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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