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MSRB3 Gene

protein-coding   GIFtS: 58
GCID: GC12P065672

Methionine Sulfoxide Reductase B3

(Previous names: deafness, autosomal recessive 74)
(Previous symbol: DFNB74)
  See MSRB3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methionine Sulfoxide Reductase B31 2     Methionine-R-Sulfoxide Reductase B3, Mitochondrial2
DFNB741 2 5     EC 1.8.4.-3
Deafness, Autosomal Recessive 741     MsrB33
Methionine-R-Sulfoxide Reductase B32     EC 1.8.4.128

External Ids:    HGNC: 273751   Entrez Gene: 2538272   Ensembl: ENSG000001740997   OMIM: 6137195   UniProtKB: Q8IXL73   

Export aliases for MSRB3 gene to outside databases

Previous GC identifers: GC12P063961 GC12P062724


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSRB3 Gene:
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts
as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have
been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic
reticula. (provided by RefSeq, Jul 2010)

GeneCards Summary for MSRB3 Gene:
MSRB3 (methionine sulfoxide reductase B3) is a protein-coding gene. Diseases associated with MSRB3 include deafness, autosomal recessive 74, and lipoma of colon. GO annotations related to this gene include peptide-methionine (R)-S-oxide reductase activity. An important paralog of this gene is MSRB2.

UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is
essential for hearing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSRB3 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   RORalpha2   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSRB3 promoter sequence
   Search Chromatin IP Primers for MSRB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3   Ensembl cytogenetic band:  12q14.3   HGNC cytogenetic band: 12q14.3

MSRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSRB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P065672:  view genomic region     (about GC identifiers)

Start:
65,672,423 bp from pter      End:
65,882,024 bp from pter
Size:
209,602 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7 (See protein sequence)
Recommended Name: Methionine-R-sulfoxide reductase B3 precursor  
Size: 192 amino acids; 20702 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer
Secondary accessions: B4DR19 B7ZAQ0 Q6UXS2
Alternative splicing: 2 isoforms:  Q8IXL7-1   Q8IXL7-2   (Has a transit peptide)

Explore the universe of human proteins at neXtProt for MSRB3: NX_Q8IXL7

Explore proteomics data for MSRB3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for MSRB3 (Q8IXL7)
     RYCINSA  CGAHLGH  GIYKCVVC  FDDGPRPTGKRYC 


    See MSRB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001026849.1  NP_001180389.1  NP_001180390.1  NP_932346.1  

    ENSEMBL proteins: 
     ENSP00000347324   ENSP00000312274   ENSP00000445051   ENSP00000437623   ENSP00000441650  
     ENSP00000440722   ENSP00000442620   ENSP00000445843   ENSP00000404903  

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    antibodies-online proteins for MSRB3 (10 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002579 Met_Sox_Rdtase_MsrB
     IPR028427 Met_Sox_Rdtase
     IPR011057 Mss4-like

    Graphical View of Domain Structure for InterPro Entry Q8IXL7

    ProtoNet protein and cluster: Q8IXL7

    1 Blocks protein domain: IPB002579 Protein of unknown function DUF25

    UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
    Similarity: Belongs to the MsrB Met sulfoxide reductase family


    Find genes that share domains with MSRB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSRB3_HUMAN, Q8IXL7
    Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is
    essential for hearing
    Catalytic activity: L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin

         Enzyme Numbers (IUBMB): EC 1.8.4.122 EC 1.8.4.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IDA14699060
    GO:0033743peptide-methionine (R)-S-oxide reductase activity IDA14699060
         
    Find genes that share ontologies with MSRB3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MSRB3

    miRNA
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    miRTarBase miRNAs that target MSRB3:
    hsa-mir-124-3p (MIRT022224), hsa-mir-192-5p (MIRT026193)

    Block miRNA regulation of human, mouse, rat MSRB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSRB3 (see all 92):
    hsa-miR-607 hsa-miR-300 hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a* hsa-miR-1304 hsa-miR-4325 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidMSRB3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MSRB3_HUMAN, Q8IXL7: Isoform 1: Endoplasmic reticulum
    MSRB3_HUMAN, Q8IXL7: Isoform 2: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    extracellular3
    chloroplast1
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA14699060
    GO:0005783endoplasmic reticulum IDA14699060

    Find genes that share ontologies with MSRB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSRB3
    Interactions:

        Search GeneGlobe Interaction Network for MSRB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MSRB3 (Q8IXL73 ENSP000003473244) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MSRAQ9UJ683, ENSP000003139214I2D: score=2 STRING: ENSP00000313921
    PSAT1Q9Y6173I2D: score=3 
    CNBPP626333I2D: score=1 
    DIAPH1O606103I2D: score=1 
    IDI1Q139073I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress IEA--
    GO:0030091protein repair IDA14699060
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with MSRB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSRB3

    1 HMDB Compound for MSRB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Methionine sulfoxideDL-Methionine sulfoxide (see all 7)62697-73-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MSRB3 gene (4 alternative transcripts): 
    NM_001031679.2  NM_001193460.1  NM_001193461.1  NM_198080.3  

    Unigene Cluster for MSRB3:

    Methionine sulfoxide reductase B3
    Hs.339024  [show with all ESTs]
    Unigene Representative Sequence: NM_001193460
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355192 ENST00000308259(uc009zqp.3 uc001ssm.3 uc001ssn.3 uc021qzy.1)
    ENST00000541897 ENST00000538725 ENST00000540804 ENST00000535664 ENST00000541189
    ENST00000538045 ENST00000535239 ENST00000446731 ENST00000535143
    miRNA
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    Block miRNA regulation of human, mouse, rat MSRB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSRB3 (see all 92):
    hsa-miR-607 hsa-miR-300 hsa-miR-3653 hsa-miR-371-5p hsa-miR-550a* hsa-miR-1304 hsa-miR-4325 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidMSRB3 3' UTR sequence
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    Additional mRNA sequence: 

    AK094185.1 AK122602.1 AK126406.1 AK293084.1 AK299065.1 AK316365.1 AL833622.1 AY358229.1 
    BC040053.1 BX640871.1 BX648776.1 DQ786269.1 

    7 DOTS entries:

    DT.100660441  DT.95161747  DT.100754508  DT.91878202  DT.121123622  DT.121123677  DT.75115428 

    Selected AceView cDNA sequences (see all 187):

    AA446357 N34511 BF939165 BU624540 AA232570 BC040053 AK094185 BE645860 
    AA122080 AL049150 T60112 AY358229 BM914782 BM706446 AA179402 BM661792 
    BF939162 BU630249 AW027211 AI288929 BX648776 AW027333 CB111777 AI085125 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSRB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTCATT
    MSRB3 Expression
    About this image


    MSRB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Vertebrae
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Epidermis (Integumentary System)
             Detroit 551
    MSRB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSRB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.339024

    UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MSRB3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msrb31 , 5 methionine sulfoxide reductase B31, 5 87.61(n)1
    94.54(a)1
      10 (68.75 cM)5
    3201831  NM_177092.41  NP_796066.11 
     1207810965 
    chicken
    (Gallus gallus)
    Aves MSRB31 methionine sulfoxide reductase B3 84.06(n)
    85.87(a)
      417833  NM_001199578.1  NP_001186507.1 
    lizard
    (Anolis carolinensis)
    Reptilia MSRB36
    methionine sulfoxide reductase B3
    72(a)
    1 ↔ 1
    5(50022759-50097445)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc07g042 Transcribed sequence with weak similarity to protein more 78.24(n)    CF998052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SelR1 SelR 53.07(n)
    51.97(a)
      41309  NM_169368.3  NP_731522.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MXR2(YCL033C)4 Methionine-R-sulfoxide reductase, involved in the response more   --   3(63282-62776) 850324  NP_009897.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MSRB11 MSRB1 55.3(n)
    57.36(a)
      841804  NM_104245.3  NP_564640.2 


    ENSEMBL Gene Tree for MSRB3 (if available)
    TreeFam Gene Tree for MSRB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSRB3 gene
    MSRB22  
    4 SIMAP similar genes for MSRB3 using alignment to 7 protein entries:     MSRB3_HUMAN (see all proteins):
    DKFZp686C1178    MSRB2    SEPX1    MSRB1

    Find genes that share paralogs with MSRB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSRB3 (see all 3186)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0649044
    Deafness, autosomal recessive, 74 (DFNB74)4--see VAR_0649042 C G mis40--------
    rs2014216801,2
    --62756058(+) GATGT-/TTTC  
            
    CTCTG
    4 -- int10--------
    rs342843281,2
    C--62756059(+) ATGTT-/TTCC  
            
    TCTGG
    4 -- int10--------
    rs723902221,2
    C--62756060(+) TGTTT-/TCCT  
            
    CTGGA
    4 -- int10--------
    rs1426457061,2
    C--62770547(+) ATGTT-/AAGTTTG 4 -- int10--------
    rs712782371,2
    C--62775001(-) CATGTT/-TGGCC 4 -- int11Minor allele frequency- -:0.50NA 2
    rs354508681,2
    C--62787081(+) ACATT-/AAAAAA 4 -- int11Minor allele frequency- A:0.00CSA 2
    rs675482661,2
    C--62814463(+) CCACA-/CCCCCC 4 -- int10--------
    rs347326041,2
    C--62827954(+) TTATT-/CTAA  
            
    CTTAG
    4 -- int10--------
    rs782994311,2
    C--62865874(+) TAAGA-/TTTTTT 4 -- int10--------

    HapMap Linkage Disequilibrium report for MSRB3 (65672423 - 65882024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MSRB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv751CNV Insertion18451855
    esv1479608CNV Insertion17803354
    nsv749CNV Insertion18451855
    nsv513363CNV Insertion21212237
    nsv750CNV Loss18451855
    nsv899211CNV Gain21882294
    nsv832445CNV Gain17160897

    Human Gene Mutation Database (HGMD): MSRB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSRB3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613719   
    OMIM disorders: 613718  
    UniProtKB/Swiss-Prot: MSRB3_HUMAN, Q8IXL7
  • Deafness, autosomal recessive, 74 (DFNB74) [MIM:613718]: A form of non-syndromic sensorineural deafness
    characterized by prelingual, bilateral, profound hearing loss. Sensorineural deafness results from damage to the
    neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound
    information. Note=The disease is caused by mutations affecting the gene represented in this entry. A nonsense
    mutation affecting exclusively mitochondrial isoform 2 is sufficient to produce hearing loss

  • 4 diseases for MSRB3:    
    About MalaCards
    deafness, autosomal recessive 74    lipoma of colon    coach syndrome    deafness, autosomal recessive 76

    1 disease from the University of Copenhagen DISEASES database for MSRB3:
    Lipoma of colon

    Find genes that share disorders with MSRB3           About GenesLikeMe

    Genetic Association Database (GAD): MSRB3
    Human Genome Epidemiology (HuGE) Navigator: MSRB3 (1 document)

    Export disorders for MSRB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSRB3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with MSRB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. (PubMed id 21185009)1, 2, 3 Ahmed Z.M.... Riazuddin S. (Am. J. Hum. Genet. 2011)
    2. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. (PubMed id 14699060)1, 2, 9 Kim H.-Y. and Gladyshev V.N. (Mol. Biol. Cell 2004)
    3. Common variants at 12q14 and 12q24 are associated with hippocampal volume. (PubMed id 22504421)1, 4 Bis J.C....Seshadri S. (Nat. Genet. 2012)
    4. A genome-wide association study for diabetic nephropathy genes in African Americans. (PubMed id 21150874)1, 4 McDonough C.W....Bowden D.W. (Kidney Int. 2011)
    5. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PubMed id 20195514)1, 4 Pillas D....Jarvelin M.R. (PLoS Genet. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Differential expression of the antioxidant repair enzyme methionine sulfoxide reductase (MSRA and MSRB) in human skin. (PubMed id 19542914)1, 9 Taungjaruwinai W.M....Thiele J.J. (Am J Dermatopathol 2009)
    9. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. (PubMed id 23704328)1 Fatemifar G....Evans D.M. (Hum. Mol. Genet. 2013)
    10. Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila. (PubMed id 22310715)1 Lim D.H....Kim H.Y. (Biochem. Biophys. Res. Commun. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 253827 HGNC: 27375 AceView: LOC253827 Ensembl:ENSG00000174099 euGenes: HUgn253827
    ECgene: MSRB3 H-InvDB: MSRB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSRB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSRB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSRB3 gene:
    Search GeneIP for patents involving MSRB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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