Aliases for MSRB3 Gene
External Ids for MSRB3 Gene
Previous HGNC Symbols for MSRB3 Gene
Previous GeneCards Identifiers for MSRB3 Gene
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
GeneCards Summary for MSRB3 Gene
MSRB3 (Methionine Sulfoxide Reductase B3) is a Protein Coding gene. Diseases associated with MSRB3 include deafness, autosomal recessive 74 and autosomal recessive non-syndromic sensorineural deafness type dfnb. Among its related pathways are Transport to the Golgi and subsequent modification and Protein repair. GO annotations related to this gene include peptide-methionine (R)-S-oxide reductase activity. An important paralog of this gene is MSRB2.
UniProtKB/Swiss-Prot for MSRB3 Gene
Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.