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Aliases for MSRB2 Gene

Aliases for MSRB2 Gene

  • Methionine Sulfoxide Reductase B2 2 3 5
  • CBS-1 3 4
  • MSRB 3 4
  • Methionine Sulfoxide Reductase B 2
  • Pilin-Like Transcription Factor 3
  • EC 1.8.4.12 63
  • EC 1.8.4.- 4
  • EC 1.8.4 63
  • CGI-131 3
  • MsrB2 4
  • CBS1 3
  • PILB 3

External Ids for MSRB2 Gene

Previous HGNC Symbols for MSRB2 Gene

  • MSRB

Previous GeneCards Identifiers for MSRB2 Gene

  • GC10P023425
  • GC10P023384

Summaries for MSRB2 Gene

GeneCards Summary for MSRB2 Gene

MSRB2 (Methionine Sulfoxide Reductase B2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Protein repair. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and peptide-methionine (R)-S-oxide reductase activity. An important paralog of this gene is MSRB3.

UniProtKB/Swiss-Prot for MSRB2 Gene

  • Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.

Gene Wiki entry for MSRB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSRB2 Gene

Genomics for MSRB2 Gene

Regulatory Elements for MSRB2 Gene

Enhancers for MSRB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MSRB2 on UCSC Golden Path with GeneCards custom track

Promoters for MSRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MSRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MSRB2 Gene

Chromosome:
10
Start:
23,095,498 bp from pter
End:
23,122,013 bp from pter
Size:
26,516 bases
Orientation:
Plus strand

Genomic View for MSRB2 Gene

Genes around MSRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSRB2 Gene

Proteins for MSRB2 Gene

  • Protein details for MSRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D2-MSRB2_HUMAN
    Recommended name:
    Methionine-R-sulfoxide reductase B2, mitochondrial
    Protein Accession:
    Q9Y3D2
    Secondary Accessions:
    • Q17R44
    • Q4G1C7
    • Q9Y5W6

    Protein attributes for MSRB2 Gene

    Size:
    182 amino acids
    Molecular mass:
    19536 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34126.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MSRB2 Gene

Proteomics data for MSRB2 Gene at MOPED

Selected DME Specific Peptides for MSRB2 Gene

Post-translational modifications for MSRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MSRB2 Gene

Protein Domains for MSRB2 Gene

Suggested Antigen Peptide Sequences for MSRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D2

UniProtKB/Swiss-Prot:

MSRB2_HUMAN :
  • Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.
  • Belongs to the MsrB Met sulfoxide reductase family.
Domain:
  • Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.
Family:
  • Belongs to the MsrB Met sulfoxide reductase family.
genes like me logo Genes that share domains with MSRB2: view

No data available for Gene Families for MSRB2 Gene

Function for MSRB2 Gene

Molecular function for MSRB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.
UniProtKB/Swiss-Prot Function:
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.

Enzyme Numbers (IUBMB) for MSRB2 Gene

Gene Ontology (GO) - Molecular Function for MSRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10375640
GO:0003779 actin binding IEA,ISS --
genes like me logo Genes that share ontologies with MSRB2: view
genes like me logo Genes that share phenotypes with MSRB2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSRB2 Gene

Localization for MSRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSRB2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSRB2 Gene COMPARTMENTS Subcellular localization image for MSRB2 gene
Compartment Confidence
cytosol 5
mitochondrion 4
chloroplast 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MSRB2 Gene

Pathways & Interactions for MSRB2 Gene

genes like me logo Genes that share pathways with MSRB2: view

Pathways by source for MSRB2 Gene

2 Reactome pathways for MSRB2 Gene

Interacting Proteins for MSRB2 Gene

Gene Ontology (GO) - Biological Process for MSRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with MSRB2: view

No data available for SIGNOR curated interactions for MSRB2 Gene

Drugs & Compounds for MSRB2 Gene

(5) Drugs for MSRB2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Methionine Approved Nutra Enzyme, substrate 0
methionine sulfoxide Experimental Pharma 0

(4) Additional Compounds for MSRB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSRB2: view

Transcripts for MSRB2 Gene

Unigene Clusters for MSRB2 Gene

Methionine sulfoxide reductase B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSRB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3:

Relevant External Links for MSRB2 Gene

GeneLoc Exon Structure for
MSRB2
ECgene alternative splicing isoforms for
MSRB2

Expression for MSRB2 Gene

mRNA expression in normal human tissues for MSRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSRB2 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for MSRB2 Gene

This gene is overexpressed in Gallbladder (8.9), Heart (8.3), and Rectum (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MSRB2 Gene



SOURCE GeneReport for Unigene cluster for MSRB2 Gene Hs.461420

mRNA Expression by UniProt/SwissProt for MSRB2 Gene

Q9Y3D2-MSRB2_HUMAN
Tissue specificity: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate.
genes like me logo Genes that share expression patterns with MSRB2: view

Protein tissue co-expression partners for MSRB2 Gene

Primer Products

In Situ Assay Products

Orthologs for MSRB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MSRB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSRB2 35
  • 80.77 (n)
  • 82.42 (a)
MSRB2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSRB2 35
  • 84.26 (n)
  • 85 (a)
MSRB2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msrb2 35
  • 81.02 (n)
  • 83.33 (a)
Msrb2 16
Msrb2 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MSRB2 35
  • 99.31 (n)
  • 99.31 (a)
MSRB2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msrb2 35
  • 81.71 (n)
  • 85.42 (a)
oppossum
(Monodelphis domestica)
Mammalia MSRB2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSRB2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSRB2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msrb2 35
  • 69.48 (n)
  • 73.24 (a)
Str.15443 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22830 35
zebrafish
(Danio rerio)
Actinopterygii msrb2 35
  • 66.92 (n)
  • 74.62 (a)
msrb2 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5765 35
worm
(Caenorhabditis elegans)
Secernentea F44E2.6 35
  • 52.12 (n)
  • 48.41 (a)
F44E2.6 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MXR2 36
  • 33 (a)
OneToMany
Species with no ortholog for MSRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSRB2 Gene

ENSEMBL:
Gene Tree for MSRB2 (if available)
TreeFam:
Gene Tree for MSRB2 (if available)

Paralogs for MSRB2 Gene

Paralogs for MSRB2 Gene

(1) SIMAP similar genes for MSRB2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MSRB2: view

Variants for MSRB2 Gene

Sequence variations from dbSNP and Humsavar for MSRB2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2296466 - 23,104,162(+) GTGTG(A/G)GCTGC reference, missense
rs1555800 -- 23,096,721(+) CCAAC(A/T)TGACT intron-variant
rs1555801 -- 23,096,781(+) ATTTG(C/T)TGTGA intron-variant
rs1555803 -- 23,101,995(+) ctggt(C/T)aggtt intron-variant
rs1555804 -- 23,104,137(+) TTAAC(A/G)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSRB2 Gene

Variant ID Type Subtype PubMed ID
esv2734017 CNV Deletion 23290073
nsv25129 CNV Loss 16902084
esv987760 CNV Deletion 20482838
esv1381341 CNV Deletion 17803354

Variation tolerance for MSRB2 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSRB2 Gene

HapMap Linkage Disequilibrium report
MSRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSRB2 Gene

Disorders for MSRB2 Gene

Relevant External Links for MSRB2

Genetic Association Database (GAD)
MSRB2
Human Genome Epidemiology (HuGE) Navigator
MSRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSRB2

No disorders were found for MSRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSRB2 Gene

Publications for MSRB2 Gene

  1. Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases. (PMID: 10375640) Huang W. … Coca-Prados M. (Gene 1999) 2 3 4 23 67
  2. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PMID: 16480945) Schallreuter K.U. … Wood J.M. (Biochem. Biophys. Res. Commun. 2006) 3 25 26
  3. Differential expression of the antioxidant repair enzyme methionine sulfoxide reductase (MSRA and MSRB) in human skin. (PMID: 19542914) Taungjaruwinai W.M. … Thiele J.J. (Am J Dermatopathol 2009) 3 23
  4. Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. (PMID: 18424444) Cabreiro F. … Petropoulos I. (J. Biol. Chem. 2008) 3 23
  5. The X-ray structure of the N-terminal domain of PILB from Neisseria meningitidis reveals a thioredoxin-fold. (PMID: 16530221) Ranaivoson F.M. … Favier F. (J. Mol. Biol. 2006) 25 26

Products for MSRB2 Gene

Sources for MSRB2 Gene

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