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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSRB2 Gene

protein-coding   GIFtS: 59
GCID: GC10P023425

Methionine Sulfoxide Reductase B2

(Previous name: methionine sulfoxide reductase B)
(Previous symbol: MSRB)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methionine Sulfoxide Reductase B21 2     Methionine-R-Sulfoxide Reductase B2, Mitochondrial2
MSRB1 2 3     Pilin-Like Transcription Factor2
CBS-12 3     EC 1.8.4.-3
Methionine Sulfoxide Reductase B1     MsrB23
CBS12     EC 1.8.48
PILB2     EC 1.8.4.128

External Ids:    HGNC: 170611   Entrez Gene: 229212   Ensembl: ENSG000001484507   OMIM: 6137825   UniProtKB: Q9Y3D23   

Export aliases for MSRB2 gene to outside databases

Previous GC identifer: GC10P023053


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MSRB2 Gene: 
MSRB2 (methionine sulfoxide reductase B2) is a protein-coding gene. Diseases associated with MSRB2 include mastitis, and vitiligo. GO annotations related to this gene include peptide-methionine (R)-S-oxide reductase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MSRB3.

UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine (By similarity).
Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the
intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival
and protein maintenance

Gene Wiki entry for MSRB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSRB2 gene promoter:
         LHX3b/Lhx3b   E47   HNF-1A   POU2F1   HNF-1   POU2F1a   LHX3a/Lhx3a   Hand1   Ik-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSRB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSRB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p12

MSRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSRB2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P023425:  view genomic region     (about GC identifiers)

Start:
23,384,427 bp from pter      End:
23,410,942 bp from pter
Size:
26,516 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2 (See protein sequence)
Recommended Name: Methionine-R-sulfoxide reductase B2, mitochondrial precursor  
Size: 182 amino acids; 19536 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAD34126.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q17R44 Q4G1C7 Q9Y5W6

Explore the universe of human proteins at neXtProt for MSRB2: NX_Q9Y3D2

Explore proteomics data for MSRB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3D2

  • 2 DME Specific Peptides for MSRB2 (Q9Y3D2)
     GHVFPDGP  GMYHCVCCDSPLFSSE 

    MSRB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MSRB2 Protein Expression
    REFSEQ proteins: NP_036360.3  
    ENSEMBL proteins: 
     ENSP00000365693   ENSP00000434990  

    Human Recombinant Protein Products for MSRB2: 
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    Novus Biologicals MSRB2 Proteins
    Novus Biologicals MSRB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MSRB2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS14699060

    MSRB2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002579 Met_Sox_Rdtase_MsrB
     IPR011057 Mss4-like

    Graphical View of Domain Structure for InterPro Entry Q9Y3D2

    ProtoNet protein and cluster: Q9Y3D2

    1 Blocks protein domain: IPB002579 Protein of unknown function DUF25

    UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
    Similarity: Belongs to the MsrB Met sulfoxide reductase family


    MSRB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSRB2_HUMAN, Q9Y3D2
    Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine (By similarity).
    Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the
    intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival
    and protein maintenance
    Catalytic activity: L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin

         Enzyme Numbers (IUBMB): EC 1.8.42 EC 1.8.4.122 EC 1.8.4.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10375640
    GO:0003779actin binding ISS--
    GO:0008270zinc ion binding ISS14699060
    GO:0033743peptide-methionine (R)-S-oxide reductase activity ISS--
         
    MSRB2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MSRB2:
     Increased circadian period len  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MSRB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MSRB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSRB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSRB2 

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MSRB2:
    hsa-miR-561 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidMSRB2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSRB2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MSRB2 (Q9Y3D23 ENSP000003656934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    MSRAENSP000003139214STRING: ENSP00000313921
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS10375640
    GO:0030041actin filament polymerization ISS--
    GO:0030091protein repair ISS14699060
    GO:0055114oxidation-reduction process ----

    MSRB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MSRB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSRB2

    1 HMDB Compound for MSRB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Methionine sulfoxideDL-Methionine sulfoxide (see all 7)62697-73-8--

    1 DrugBank Compound for MSRB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate16530221 16480945

    8 Novoseek inferred chemical compound relationships for MSRB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methionine sulfoxide 97.5 44 18424444 (5), 19373970 (3), 15853675 (3), 20026324 (2) (see all 21)
    methionine 81.6 25 18505275 (2), 15820754 (1), 17673175 (1), 17180746 (1) (see all 14)
    sulfoxide 79 6 15820754 (1), 18302927 (1), 15680233 (1), 18505275 (1) (see all 6)
    cysteine 42.2 1 17761174 (1)
    oxygen 36.7 4 18424444 (2), 17180746 (1), 14699060 (1)
    h2o2 32.9 1 19373970 (1)
    zinc 16 1 15680231 (1)
    hydrogen 4.92 1 18424444 (1)

    Search CenterWatch for drugs/clinical trials and news about MSRB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSRB2 gene: 
    NM_012228.3  

    Unigene Cluster for MSRB2:

    Methionine sulfoxide reductase B2
    Hs.461420  [show with all ESTs]
    Unigene Representative Sequence: NM_012228
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376510(uc001iro.3) ENST00000472663 ENST00000468633
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MSRB2:
    hsa-miR-561 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidMSRB2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MSRB2 (NM_012228)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSRB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSRB2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSRB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSRB2

    Additional mRNA sequence: 

    AF122004.1 AF151889.1 BC018030.1 BC066305.1 BC117471.1 BC130380.1 

    4 DOTS entries:

    DT.100762522  DT.446679  DT.92425934  DT.95069706 

    24/171 AceView cDNA sequences (see all 171):

    CK906139 AA496070 AA295924 AI245642 AI674575 AW300575 BU180447 AI393995 
    R16571 BU739503 BQ447603 AI884901 AI417366 BE858431 AW028507 AI301168 
    CA771410 BF197163 N46210 AI613101 CD368684 AA040126 AA149824 BM711634 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MSRB2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                          -                     
    SP2:                          -                     
    SP3:                                                


    ECgene alternative splicing isoforms for MSRB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSRB2 expression in normal human tissues (normalized intensities)      MSRB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACGTCTGG
    MSRB2 Expression
    About this image


    MSRB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
             lung ; macrophages   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, post-menopause ; glandular cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   

    See MSRB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSRB2

    SOURCE GeneReport for Unigene cluster: Hs.461420

    UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
    Tissue specificity: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone
    marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate

        SABiosciences Custom PCR Arrays for MSRB2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MSRB2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msrb21 , 5 methionine sulfoxide reductase B21, 5 76.82(n)1
    79.89(a)1
      2 (13.26 cM)5
    764671  NM_029619.21  NP_083895.11 
     193714405 
    lizard
    (Anolis carolinensis)
    Reptilia MSRB26
    methionine sulfoxide reductase B2
    57(a)
    1 ↔ 1
    6(15989875-16004378)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.228302 Xenopus laevis transcribed sequence with moderate similarity more 73.84(n)    BJ069449.1 
    zebrafish
    (Danio rerio)
    Actinopterygii msrb21 methionine sulfoxide reductase B2 66.92(n)
    74.62(a)
      405857  NM_212921.1  NP_998086.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F44E2.61 Protein F44E2.6 52.96(n)
    49.19(a)
      176244  NM_066553.3  NP_498954.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MXR26
    Methionine-R-sulfoxide reductase, involved in the ...
    33(a)
    1 → many
    III(62776-63282)


    ENSEMBL Gene Tree for MSRB2 (if available)
    TreeFam Gene Tree for MSRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSRB2 gene
    MSRB32  
    1 SIMAP similar gene for MSRB2 using alignment to 3 protein entries:     MSRB2_HUMAN (see all proteins):
    MSRB3

    MSRB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/641 SNPs in MSRB2 are shown (see all 641)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889283471,2
    --23382514(+) AAATAC/GAAAAG 1 -- us2k10--------
    rs1389493061,2
    C--23382619(+) ATGTAA/GAAATA 1 -- us2k10--------
    rs744495531,2
    C--23382849(+) CTGGCC/TAACAT 1 -- us2k10--------
    rs1504111351,2
    C--23382902(+) CGTGGA/TGGCAC 1 -- us2k10--------
    rs1381393511,2
    --23382941(+) CTGAGA/GCAGAA 1 -- us2k10--------
    rs1496007261,2
    --23383044(+) TCAATA/CAATCA 1 -- us2k10--------
    rs1932362911,2
    --23383110(+) ATAAAC/TAAAAC 1 -- us2k10--------
    rs287874411,2
    C--23383136(+) GCCATA/GTATAA 1 -- us2k12Minor allele frequency- G:0.31CSA WA 119
    rs1838878461,2
    --23383192(+) AAAAAG/TTTTAG 1 -- us2k10--------
    rs618498891,2
    C--23383295(+) ATAAAT/CTGGGC 1 -- us2k14Minor allele frequency- C:0.16NA WA EA 360

    HapMap Linkage Disequilibrium report for MSRB2 (23384427 - 23410942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MSRB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734017CNV Deletion23290073
    esv1381341CNV Deletion17803354
    esv987760CNV Deletion20482838
    nsv25129CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613782    OMIM disorders: --

    8 diseases for MSRB2:    About MalaCards
    mastitis    vitiligo    pneumonia    tuberculosis
    retinitis    alzheimer's disease    leukemia    prostatitis


    MSRB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): MSRB2
    Human Genome Epidemiology (HuGE) Navigator: MSRB2 (4 documents)

    Export disorders for MSRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSRB2 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with MSRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases. (PubMed id 10375640)1, 2, 3, 9 Huang W.... Coca-Prados M. (1999)
    2. Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. (PubMed id 18424444)1, 2, 9 Cabreiro F....Petropoulos I. (2008)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PubMed id 16480945)1, 7 Schallreuter K.U....Wood J.M. (2006)
    8. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    9. Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins. (PubMed id 8749308)1, 3 Escribano J....Coca-Prados M. (1995)
    10. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. (PubMed id 14699060)1, 9 Kim H.-Y. and Gladyshev V.N. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22921 HGNC: 17061 AceView: MSRB Ensembl:ENSG00000148450 euGenes: HUgn22921
    ECgene: MSRB2 H-InvDB: MSRB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSRB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSRB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSRB2 gene:
    Search GeneIP for patents involving MSRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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