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MSRB2 Gene

protein-coding   GIFtS: 58
GCID: GC10P023384

Methionine Sulfoxide Reductase B2

(Previous name: methionine sulfoxide reductase B)
(Previous symbol: MSRB)
  Search for MSRB2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methionine Sulfoxide Reductase B21 2     Methionine-R-Sulfoxide Reductase B2, Mitochondrial2
MSRB1 2 3     Pilin-Like Transcription Factor2
CBS-12 3     EC 1.8.4.-3
CBS12 5     MsrB23
Methionine Sulfoxide Reductase B1     EC 1.8.48
PILB2     EC 1.8.4.128

External Ids:    HGNC: 170611   Entrez Gene: 229212   Ensembl: ENSG000001484507   OMIM: 6137825   UniProtKB: Q9Y3D23   

Export aliases for MSRB2 gene to outside databases

Previous GC identifers: GC10P023425 GC10P023053


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MSRB2 Gene:
MSRB2 (methionine sulfoxide reductase B2) is a protein-coding gene. GO annotations related to this gene include peptide-methionine (R)-S-oxide reductase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MSRB3.

UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine.
While in many cases, methionine oxidation is the result of random oxidation following oxidative stress,
methionine oxidation is also a post-translational modification that takes place on specific residue. Upon
oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular
reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein
maintenance

Gene Wiki entry for MSRB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSRB2 gene promoter:
         LHX3b/Lhx3b   E47   HNF-1A   POU2F1   HNF-1   POU2F1a   LHX3a/Lhx3a   Hand1   Ik-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSRB2 promoter sequence
   Search Chromatin IP Primers for MSRB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p12

MSRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSRB2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P023384:  view genomic region     (about GC identifiers)

Start:
23,384,427 bp from pter      End:
23,410,942 bp from pter
Size:
26,516 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2 (See protein sequence)
Recommended Name: Methionine-R-sulfoxide reductase B2, mitochondrial precursor  
Size: 182 amino acids; 19536 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Sequence caution: Sequence=AAD34126.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q17R44 Q4G1C7 Q9Y5W6

Explore the universe of human proteins at neXtProt for MSRB2: NX_Q9Y3D2

Explore proteomics data for MSRB2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for MSRB2 (Q9Y3D2)
     GHVFPDGP  GMYHCVCCDSPLFSSE 


    See MSRB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036360.3  
    ENSEMBL proteins: 
     ENSP00000365693   ENSP00000434990  

    MSRB2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002579 Met_Sox_Rdtase_MsrB
     IPR028427 Met_Sox_Rdtase
     IPR011057 Mss4-like

    Graphical View of Domain Structure for InterPro Entry Q9Y3D2

    ProtoNet protein and cluster: Q9Y3D2

    1 Blocks protein domain: IPB002579 Protein of unknown function DUF25

    UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
    Similarity: Belongs to the MsrB Met sulfoxide reductase family


    Find genes that share domains with MSRB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSRB2_HUMAN, Q9Y3D2
    Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine.
    While in many cases, methionine oxidation is the result of random oxidation following oxidative stress,
    methionine oxidation is also a post-translational modification that takes place on specific residue. Upon
    oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular
    reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein
    maintenance
    Catalytic activity: L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin

         Enzyme Numbers (IUBMB): EC 1.8.42 EC 1.8.4.122 EC 1.8.4.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10375640
    GO:0003779actin binding ISS--
    GO:0008270zinc ion binding ISS14699060
    GO:0033743peptide-methionine (R)-S-oxide reductase activity ISS--
         
    Find genes that share ontologies with MSRB2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MSRB2:
     Increased circadian period len  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSRB2
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    2 qRT-PCR Assays for microRNAs that regulate MSRB2:
    hsa-miR-561 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidMSRB2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MSRB2_HUMAN, Q9Y3D2: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS14699060

    Find genes that share ontologies with MSRB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSRB2
    Interactions:

        Search GeneGlobe Interaction Network for MSRB2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MSRB2 (Q9Y3D23 ENSP000003656934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523I2D: score=1 
    MSRAENSP000003139214STRING: ENSP00000313921
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS10375640
    GO:0006979response to oxidative stress IEA--
    GO:0030041actin filament polymerization ISS--
    GO:0030091protein repair ISS14699060
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with MSRB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSRB2

    1 HMDB Compound for MSRB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Methionine sulfoxideDL-Methionine sulfoxide (see all 7)62697-73-8--

    1 DrugBank Compound for MSRB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate16530221 16480945

    8 Novoseek inferred chemical compound relationships for MSRB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methionine sulfoxide 97.5 44 18424444 (5), 19373970 (3), 15853675 (3), 20026324 (2) (see all 21)
    methionine 81.6 25 18505275 (2), 15820754 (1), 17673175 (1), 17180746 (1) (see all 14)
    sulfoxide 79 6 15820754 (1), 18302927 (1), 15680233 (1), 18505275 (1) (see all 6)
    cysteine 42.2 1 17761174 (1)
    oxygen 36.7 4 18424444 (2), 17180746 (1), 14699060 (1)
    h2o2 32.9 1 19373970 (1)
    zinc 16 1 15680231 (1)
    hydrogen 4.92 1 18424444 (1)



    Find genes that share compounds with MSRB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MSRB2 gene: 
    NM_012228.3  

    Unigene Cluster for MSRB2:

    Methionine sulfoxide reductase B2
    Hs.461420  [show with all ESTs]
    Unigene Representative Sequence: NM_012228
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376510(uc001iro.3) ENST00000472663 ENST00000468633
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate MSRB2:
    hsa-miR-561 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidMSRB2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MSRB2
      QuantiFast Probe-based Assays in human, mouse, rat MSRB2

    Additional mRNA sequence: 

    AF122004.1 AF151889.1 BC018030.1 BC066305.1 BC117471.1 BC130380.1 

    4 DOTS entries:

    DT.100762522  DT.446679  DT.92425934  DT.95069706 

    Selected AceView cDNA sequences (see all 171):

    BQ955757 AI674575 AW300575 BU180447 AI393995 R16571 BU739503 AI884901 
    AI417366 BE858431 AW028507 AI301168 CA771410 BF197163 N46210 AI613101 
    CD368684 AA040126 AA149824 BM711634 CK906139 BQ447603 AA295924 AA496070 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MSRB2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                          -                     
    SP2:                          -                     
    SP3:                                                


    ECgene alternative splicing isoforms for MSRB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACGTCTGG
    MSRB2 Expression
    About this image


    MSRB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
    MSRB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSRB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461420

    UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
    Tissue specificity: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone
    marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MSRB2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msrb21 , 5 methionine sulfoxide reductase B21, 5 81.02(n)1
    83.33(a)1
      2 (13.26 cM)5
    764671  NM_029619.21  NP_083895.11 
     193714405 
    lizard
    (Anolis carolinensis)
    Reptilia MSRB26
    methionine sulfoxide reductase B2
    54(a)
    1 ↔ 1
    6(15989875-16004378)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.228302 Xenopus laevis transcribed sequence with moderate similarity more 73.84(n)    BJ069449.1 
    zebrafish
    (Danio rerio)
    Actinopterygii msrb21 methionine sulfoxide reductase B2 66.92(n)
    74.62(a)
      405857  NM_212921.1  NP_998086.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F44E2.61 F44E2.6 52.12(n)
    48.41(a)
      176244  NM_001268037.1  NP_001254966.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MXR26
    Methionine-R-sulfoxide reductase, involved in the ...
    33(a)
    1 → many
    III(62776-63282) YCL033C


    ENSEMBL Gene Tree for MSRB2 (if available)
    TreeFam Gene Tree for MSRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSRB2 gene
    MSRB32  
    1 SIMAP similar gene for MSRB2 using alignment to 3 protein entries:     MSRB2_HUMAN (see all proteins):
    MSRB3

    Find genes that share paralogs with MSRB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSRB2 (see all 641)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889283471,2
    --23382514(+) AAATAC/GAAAAG 1 -- us2k10--------
    rs1389493061,2
    C--23382619(+) ATGTAA/GAAATA 1 -- us2k10--------
    rs744495531,2
    C--23382849(+) CTGGCC/TAACAT 1 -- us2k10--------
    rs1504111351,2
    C--23382902(+) CGTGGA/TGGCAC 1 -- us2k10--------
    rs1381393511,2
    --23382941(+) CTGAGA/GCAGAA 1 -- us2k10--------
    rs1496007261,2
    --23383044(+) TCAATA/CAATCA 1 -- us2k10--------
    rs1932362911,2
    --23383110(+) ATAAAC/TAAAAC 1 -- us2k10--------
    rs287874411,2
    C--23383136(+) GCCATA/GTATAA 1 -- us2k12Minor allele frequency- G:0.31CSA WA 119
    rs1838878461,2
    --23383192(+) AAAAAG/TTTTAG 1 -- us2k10--------
    rs618498891,2
    C--23383295(+) ATAAAT/CTGGGC 1 -- us2k14Minor allele frequency- C:0.16NA WA EA 360

    HapMap Linkage Disequilibrium report for MSRB2 (23384427 - 23410942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MSRB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734017CNV Deletion23290073
    esv1381341CNV Deletion17803354
    esv987760CNV Deletion20482838
    nsv25129CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSRB2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613782    OMIM disorders: --


    Find genes that share disorders with MSRB2           About GenesLikeMe

    Genetic Association Database (GAD): MSRB2
    Human Genome Epidemiology (HuGE) Navigator: MSRB2 (4 documents)

    Export disorders for MSRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSRB2 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with MSRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases. (PubMed id 10375640)1, 2, 3, 9 Huang W.... Coca-Prados M. (Gene 1999)
    2. Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. (PubMed id 18424444)1, 2, 9 Cabreiro F....Petropoulos I. (J. Biol. Chem. 2008)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PubMed id 16480945)1, 7 Schallreuter K.U....Wood J.M. (Biochem. Biophys. Res. Commun. 2006)
    8. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    9. Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins. (PubMed id 8749308)1, 3 Escribano J....Coca-Prados M. (J. Biochem. 1995)
    10. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. (PubMed id 14699060)1, 9 Kim H.-Y. and Gladyshev V.N. (Mol. Biol. Cell 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22921 HGNC: 17061 AceView: MSRB Ensembl:ENSG00000148450 euGenes: HUgn22921
    ECgene: MSRB2 H-InvDB: MSRB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSRB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSRB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSRB2 gene:
    Search GeneIP for patents involving MSRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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