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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSRB2 Gene

protein-coding   GIFtS: 54
GCID: GC10P023425

methionine sulfoxide reductase B2

(Previous name: methionine sulfoxide reductase B )
(Previous symbol: MSRB)
 Explore 9 diseases affiliated with
MSRB2 via our new
 Human Malady Compendium 
Biological research products
for MSRB2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Methionine Sulfoxide Reductase B21 2     Methionine-R-Sulfoxide Reductase B2, Mitochondrial2
CBS-11 2 3     Pilin-Like Transcription Factor2
MSRB1 2 3     EC 1.8.4.-3
CBS11 2     MsrB23
PILB1 2     EC 1.8.48
CGI-1311     EC 1.8.4.128
Methionine Sulfoxide Reductase B1     

External Ids:    HGNC: 170611   Entrez Gene: 229212   Ensembl: ENSG000001484507   OMIM: 6137825   UniProtKB: Q9Y3D23   

Export aliases for MSRB2 gene to outside databases

Previous GC identifer: GC10P023053


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine (By similarity). Upon
oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular
reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein
maintenance

Gene Wiki entry for MSRB2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSRB2 gene promoter:
         LHX3b/Lhx3b   E47   HNF-1A   POU2F1   HNF-1   POU2F1a   LHX3a/Lhx3a   Hand1   Ik-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSRB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSRB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p12

MSRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSRB2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P023425:  view genomic region     (about GC identifiers)

Start:
23,384,427 bp from pter      End:
23,410,942 bp from pter
Size:
26,516 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2 (See protein sequence)
Recommended Name: Methionine-R-sulfoxide reductase B2, mitochondrial precursor  
Size: 182 amino acids; 19536 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAD34126.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q17R44 Q4G1C7 Q9Y5W6

Explore the universe of human proteins at neXtProt for MSRB2: NX_Q9Y3D2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y3D2

  • 2 DME Specific Peptides for MSRB2 (Q9Y3D2)
     GHVFPDGP  GMYHCVCCDSPLFSSE 

    MSRB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036360.3  
    ENSEMBL proteins: 
     ENSP00000365693   ENSP00000434990  

    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for MSRB2
    Uscn Proteins for MSRB2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS14699060


    MSRB2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MSRB2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MSRB2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002579 Met_Sox_Rdtase_MsrB
     IPR011057 Mss4-like

    Graphical View of Domain Structure for InterPro Entry Q9Y3D2

    ProtoNet protein and cluster: Q9Y3D2

    1 Blocks protein family: IPB002579 Protein of unknown function DUF25

    UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
    Similarity: Belongs to the MsrB Met sulfoxide reductase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
    Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine (By similarity). Upon
    oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular
    reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein
    maintenance
    Catalytic activity: L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin

    Enzyme Numbers (IUBMB): EC 1.8.42 EC 1.8.4.122 EC 1.8.4.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSRB2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MSRB2:
    hsa-miR-561 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidMSRB2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSRB2 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSRB2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10375640
    GO:0008113peptide-methionine (S)-S-oxide reductase activity ----
    GO:0008270zinc ion binding ISS14699060
    GO:0033743peptide-methionine (R)-S-oxide reductase activity ISS14699060


    MSRB2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MSRB2:
     Increased circadian period len  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSRB2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MSRB2 (Q9Y3D23 ENSP000003656934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    MSRAENSP000003139214STRING: ENSP00000313921
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS10375640
    GO:0030091protein repair ISS14699060


    MSRB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MSRB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSRB2

    1 HMDB Compound for MSRB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Methionine sulfoxideDL-Methionine sulfoxide (see all 7)62697-73-8--

    1 DrugBank Compound for MSRB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate16530221 16480945

    8 Novoseek chemical compound relationships for MSRB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methionine sulfoxide 97.5 44 18424444 (5), 19373970 (3), 15853675 (3), 20026324 (2) (see all 21)
    methionine 81.6 25 18505275 (2), 15820754 (1), 17673175 (1), 17180746 (1) (see all 14)
    sulfoxide 79 6 15820754 (1), 18302927 (1), 15680233 (1), 18505275 (1) (see all 6)
    cysteine 42.2 1 17761174 (1)
    oxygen 36.7 4 18424444 (2), 17180746 (1), 14699060 (1)
    h2o2 32.9 1 19373970 (1)
    zinc 16 1 15680231 (1)
    hydrogen 4.92 1 18424444 (1)

    Search CenterWatch for drugs/clinical trials and news about MSRB2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSRB2 gene: 
    NM_012228.3  

    Unigene Cluster for MSRB2:

    Methionine sulfoxide reductase B2
    Hs.461420  [show with all ESTs]
    Unigene Representative Sequence: NM_012228
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376510(uc001iro.3) ENST00000472663 ENST00000468633

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MSRB2:
    hsa-miR-561 hsa-miR-4282
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSRB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSRB2

    Additional cDNA sequence: 

    AF122004.1 AF151889.1 BC018030.1 BC066305.1 BC117471.1 BC130380.1 

    4 DOTS entries:

    DT.100762522  DT.446679  DT.92425934  DT.95069706 

    24/171 AceView cDNA sequences (see all 171):

    BU180447 AI393995 AA496070 AI417366 R16571 AA040126 AA149824 AI613101 
    AI674575 BE858431 CA771410 BF197163 AW028507 CD368684 AI245642 BQ955757 
    BU739503 AI884901 BQ447603 BM711634 N46210 AW300575 AI301168 CK906139 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MSRB2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                          -                     
    SP2:                          -                     
    SP3:                                                


    ECgene alternative splicing isoforms for MSRB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTACGTCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MSRB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSRB2

    SOURCE GeneReport for Unigene cluster: Hs.461420

    UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2
    Tissue specificity: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow,
    cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MSRB2 gene from 10/32 species (see all 32)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msrb21 , 5 methionine sulfoxide reductase B21, 5 76.82(n)1
    79.89(a)1
      2 (13.26 cM)5
    764671  NM_029619.21  NP_083895.11 
     193714405 
    chicken
    (Gallus gallus)
    Aves E1C1X3_CHICK6
    SEPX16
    Uncharacterized protein
    37(a)
    35(a)
    possible ortholog
    possible ortholog
    1(35852412-35930275)
    14(6138333-6151618)
    lizard
    (Anolis carolinensis)
    Reptilia SEPX16
    MSRB36
    --
    40(a)
    37(a)
    possible ortholog
    possible ortholog
    GL343263.1(2010380-2010505)
    5(50022857-50249880)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.228302 Xenopus laevis transcribed sequence with moderate similarity more 73.84(n)    BJ069449.1 
    zebrafish
    (Danio rerio)
    Actinopterygii msrb21 methionine sulfoxide reductase B2 66.92(n)
    74.62(a)
      405857  NM_212921.1  NP_998086.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SelR6
    SelR
    31(a)
    possible ortholog
    3R(6689077-6694379)
    worm
    (Caenorhabditis elegans)
    Secernentea F44E2.61 Protein F44E2.6 52.96(n)
    49.19(a)
      176244  NM_066553.3  NP_498954.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MSRB56
    ATMSRB76
    (see all 9)
    peptide methionine sulfoxide reductase B7
    (see all 9)
    40(a)
    38(a)
    (see all 9)
    possible ortholog
    possible ortholog
    (see all 9)
    4(2445794-2447086)
    4(11584346-11585419)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    peptide methionine sulfoxide reductase msrB, putat...
    peptide methionine sulfoxide reductase msrB, putat...
    (see all 3)
    40(a)
    34(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3(14008882-14012549)
    6(15717518-15720375)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria msrB6
    methionine sulfoxide reductase B
    48(a)
    possible ortholog
    Chromosome(1860040-1860453)


    ENSEMBL Gene Tree for MSRB2 (if available)
    TreeFam Gene Tree for MSRB2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSRB2 gene
    MSRB32  
    1 SIMAP similar gene for MSRB2 using alignment to 3 protein entries:     MSRB2_HUMAN (see all proteins):
    MSRB3

    MSRB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/529 NCBI SNPs in MSRB2 are shown (see all 529    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889283471,2
    --23382514(+) AAATAC/GAAAAG 1 -- us2k10--------
    rs1389493061,2
    --23382619(+) ATGTAA/GAAATA 1 -- us2k10--------
    rs744495531,2
    C,--23382849(+) CTGGCC/TAACAT 1 -- us2k10--------
    rs1504111351,2
    --23382902(+) CGTGGA/TGGCAC 1 -- us2k10--------
    rs1381393511,2
    --23382941(+) CTGAGA/GCAGAA 1 -- us2k10--------
    rs1496007261,2
    --23383044(+) TCAATA/CAATCA 1 -- us2k10--------
    rs1932362911,2
    --23383110(+) ATAAAC/TAAAAC 1 -- us2k10--------
    rs287874411,2
    C,--23383136(+) GCCATA/GTATAA 1 -- us2k12Minor allele frequency- G:0.31CSA WA 119
    rs1838878461,2
    --23383192(+) AAAAAG/TTTTAG 1 -- us2k10--------
    rs618498891,2
    C,--23383295(+) ATAAAT/CTGGGC 1 -- us2k14Minor allele frequency- C:0.16NA WA EA 360

    HapMap Linkage Disequilibrium report for MSRB2 (23384427 - 23410942 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MSRB2: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MSRB2 for disorders           About GeneDecksing

    OMIM gene information: 613782    OMIM disorders: --

    9 diseases for MSRB2:    About MalaCards
    mastitis    vitiligo    alzheimer's disease    pneumonia
    retinitis    tuberculosis    leukemia    prostatitis
    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: MSRB2 (4 documents)

    Export disorders for MSRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSRB2 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with MSRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases. (PubMed id 10375640)1, 2, 3, 9 Huang W.... Coca-Prados M. (1999)
    2. Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. (PubMed id 18424444)1, 2, 9 Cabreiro F....Petropoulos I. (2008)
    3. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PubMed id 16480945)1, 7 Schallreuter K.U....Wood J.M. (2006)
    4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    5. Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins. (PubMed id 8749308)1, 3 Escribano J....Coca-Prados M. (1995)
    6. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. (PubMed id 14699060)1, 9 Kim H.-Y. and Gladyshev V.N. (2004)
    7. Differential expression of the antioxidant repair enz yme methionine sulfoxide reductase (MSRA and MSRB) in human skin. (PubMed id 19542914)1, 9 Taungjaruwinai W.M....Thiele J.J. (2009)
    8. The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts. (PubMed id 14759519)1, 9 Picot C.R....Petropoulos I. (2004)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22921 HGNC: 17061 AceView: MSRB Ensembl:ENSG00000148450 euGenes: HUgn22921
    ECgene: MSRB2 H-InvDB: MSRB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSRB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSRB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSRB2 gene:
    Search GeneIP for patents involving MSRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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