MSRB2 Gene
protein-coding GIFtS: 54
GCID: GC10P023425
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methionine sulfoxide reductase B2(Previous name: methionine sulfoxide reductase B ) (Previous symbol: MSRB)
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Aliases for MSRB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Methionine Sulfoxide Reductase B21 2 | | Methionine-R-Sulfoxide Reductase B2, Mitochondrial2 | | CBS-11 2 3 | | Pilin-Like Transcription Factor2 | | MSRB1 2 3 | | EC 1.8.4.-3 | | CBS11 2 | | MsrB23 | | PILB1 2 | | EC 1.8.48 | | CGI-1311 | | EC 1.8.4.128 | | Methionine Sulfoxide Reductase B1 | | |
Export aliases for MSRB2 gene to outside databasesPrevious GC identifer: GC10P023053 |
Summaries for MSRB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine (By similarity). Uponoxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellularreactive oxygen species build-up through its scavenging role, hence contributing to cell survival and proteinmaintenance Gene Wiki entry for MSRB2
|
Genomic Views for MSRB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MSRB2 gene promoter: LHX3b/Lhx3b E47 HNF-1A POU2F1 HNF-1 POU2F1a LHX3a/Lhx3a Hand1 Ik-1 RSRFC4 Other transcription factors
Search SABiosciences Chromatin IP Primers for MSRB2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSRB2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p12 Ensembl cytogenetic band: 10p12.2 HGNC cytogenetic band: 10p12MSRB2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P023425: view genomic region
(about GC identifiers)
Start:
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23,384,427 bp from pter |
End:
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23,410,942 bp from pter |
Size:
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26,516 bases |
Orientation:
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plus strand |
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Proteins for MSRB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2 (See
protein sequence)Recommended Name: Methionine-R-sulfoxide reductase B2, mitochondrial precursor Size: 182 amino acids; 19536 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAD34126.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q17R44 Q4G1C7 Q9Y5W6Explore the universe of human proteins at neXtProt for MSRB2: NX_Q9Y3D2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3D2 2 DME Specific Peptides for MSRB2 (Q9Y3D2)
MSRB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036360.3 ENSEMBL proteins: ENSP00000365693 ENSP00000434990 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
MSRB2 for ontologies About GeneDecksing
MSRB2 Antibody Products: Assay Products for MSRB2: |
Protein
Domains / Families for MSRB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MSRB2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y3D2ProtoNet protein and cluster: Q9Y3D2 1 Blocks protein family: IPB002579 Protein of unknown function DUF25
UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2Similarity: Belongs to the MsrB Met sulfoxide reductase family |
Function for MSRB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2Function: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine (By similarity). Uponoxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellularreactive oxygen species build-up through its scavenging role, hence contributing to cell survival and proteinmaintenanceCatalytic activity: L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxinEnzyme Numbers (IUBMB): EC 1.8.42 EC 1.8.4.122 EC 1.8.4.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSRB2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSRB2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MSRB2 (NM_012228) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MSRB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSRB2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MSRB2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MSRB2:
|
Pathways & Interactions for MSRB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSRB2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 3 Interacting proteins for MSRB2 (Q9Y3D23 ENSP000003656934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MSRB2 for ontologies About GeneDecksing
|
Drugs & Compounds for MSRB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MSRB2 for compounds About GeneDecksing
Browse Tocris compounds for MSRB2
1 HMDB Compound for MSRB2 About this table
1 DrugBank Compound for MSRB2 About this table
8 Novoseek chemical compound relationships for MSRB2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| methionine sulfoxide |
97.5 |
44 |
18424444 (5), 19373970 (3), 15853675 (3), 20026324 (2) (see all 21) |
| methionine |
81.6 |
25 |
18505275 (2), 15820754 (1), 17673175 (1), 17180746 (1) (see all 14) |
| sulfoxide |
79 |
6 |
15820754 (1), 18302927 (1), 15680233 (1), 18505275 (1) (see all 6) |
| cysteine |
42.2 |
1 |
17761174 (1) |
| oxygen |
36.7 |
4 |
18424444 (2), 17180746 (1), 14699060 (1) |
| h2o2 |
32.9 |
1 |
19373970 (1) |
| zinc |
16 |
1 |
15680231 (1) |
| hydrogen |
4.92 |
1 |
18424444 (1) |
Search CenterWatch for drugs/clinical trials and news about MSRB2 
|
Transcripts for MSRB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MSRB2 gene: NM_012228.3 Unigene Cluster for MSRB2: Methionine sulfoxide reductase B2 Hs.461420 [show with all ESTs]Unigene Representative Sequence: NM_0122283 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376510(uc001iro.3) ENST00000472663 ENST00000468633
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSRB2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSRB2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MSRB2 (NM_012228) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MSRB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSRB2  |
Additional cDNA sequence: AF122004.1 AF151889.1 BC018030.1 BC066305.1 BC117471.1 BC130380.1 4 DOTS entries: DT.100762522 DT.446679 DT.92425934 DT.95069706 24/171 AceView cDNA sequences (see all 171): BU180447 AI393995 AA496070 AI417366 R16571 AA040126 AA149824 AI613101 AI674575 BE858431 CA771410 BF197163 AW028507 CD368684 AI245642 BQ955757 BU739503 AI884901 BQ447603 BM711634 N46210 AW300575 AI301168 CK906139 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MSRB2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MSRB2
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Expression for MSRB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MSRB2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GTACGTCTGG
About this image See MSRB2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MSRB2
SOURCE GeneReport for Unigene cluster: Hs.461420 UniProtKB/Swiss-Prot: MSRB2_HUMAN, Q9Y3D2Tissue specificity: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow,cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate SABiosciences Custom PCR Arrays for MSRB2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSRB2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSRB2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSRB2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSRB2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB2 |
Orthologs for MSRB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MSRB2 gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for MSRB2 (if available) TreeFam Gene Tree for MSRB2 (if available)  |
Paralogs for MSRB2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MSRB2 gene
- MSRB32
1 SIMAP similar gene for MSRB2 using alignment to 3 protein entries: MSRB2_HUMAN (see all proteins):MSRB3
MSRB2 for paralogs About GeneDecksing
|
Genomic Variants for MSRB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 10 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for MSRB2 (23384427 - 23410942 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MSRB2: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSRB2 |
|
Disorders
/ Diseases for MSRB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MSRB2 for disorders About GeneDecksing
OMIM gene information: 613782
OMIM disorders: --
9 diseases for MSRB2: About MalaCardsmastitis vitiligo alzheimer's disease pneumonia retinitis tuberculosis leukemia prostatitis mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: MSRB2 (4 documents) Export disorders for MSRB2 gene to outside databases
|
Publications for MSRB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MSRB2 gene, integrated from 9 sources (see all 54): (articles sorted by number of sources associating them with MSRB2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases. (PubMed id 10375640)1, 2, 3, 9 Huang W.... Coca-Prados M. (1999)
- Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. (PubMed id 18424444)1, 2, 9 Cabreiro F....Petropoulos I. (2008)
- Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PubMed id 16480945)1, 7 Schallreuter K.U....Wood J.M. (2006)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins. (PubMed id 8749308)1, 3 Escribano J....Coca-Prados M. (1995)
- Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. (PubMed id 14699060)1, 9 Kim H.-Y. and Gladyshev V.N. (2004)
- Differential expression of the antioxidant repair enz yme methionine sulfoxide reductase (MSRA and MSRB) in human skin. (PubMed id 19542914)1, 9 Taungjaruwinai W.M....Thiele J.J. (2009)
- The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts. (PubMed id 14759519)1, 9 Picot C.R....Petropoulos I. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
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External Searches for MSRB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MSRB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MSRB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MSRB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for MSRB2 gene: Search GeneIP for patents involving MSRB2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MSRB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MSRB2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSRB2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSRB2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSRB2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSRB2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSRB2 |
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| | | Search Tocris compounds for MSRB2 |
| |  |  |  |  | | | | | Recombinant Protein for MSRB2 |
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 | | MSRB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB2 |
|  |  |  | | | Search ThermoFisher Antibodies for MSRB2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSRB2 |
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