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Aliases for MSRB2 Gene

Aliases for MSRB2 Gene

  • Methionine Sulfoxide Reductase B2 2 3
  • CBS-1 3 4
  • MSRB 3 4
  • CBS1 3 6
  • Methionine-R-Sulfoxide Reductase B2, Mitochondrial 3
  • Methionine Sulfoxide Reductase B 2
  • Pilin-Like Transcription Factor 3
  • EC 1.8.4.12 63
  • EC 1.8.4.- 4
  • EC 1.8.4 63
  • CGI-131 3
  • MsrB2 4
  • PILB 3

External Ids for MSRB2 Gene

Previous HGNC Symbols for MSRB2 Gene

  • MSRB

Previous GeneCards Identifiers for MSRB2 Gene

  • GC10P023425
  • GC10P023384

Summaries for MSRB2 Gene

GeneCards Summary for MSRB2 Gene

MSRB2 (Methionine Sulfoxide Reductase B2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and peptide-methionine (R)-S-oxide reductase activity. An important paralog of this gene is MSRB3.

UniProtKB/Swiss-Prot for MSRB2 Gene

  • Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.

Gene Wiki entry for MSRB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSRB2 Gene

Genomics for MSRB2 Gene

Regulatory Elements for MSRB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MSRB2 Gene

Start:
23,095,498 bp from pter
End:
23,122,013 bp from pter
Size:
26,516 bases
Orientation:
Plus strand

Genomic View for MSRB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSRB2 Gene

Proteins for MSRB2 Gene

  • Protein details for MSRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D2-MSRB2_HUMAN
    Recommended name:
    Methionine-R-sulfoxide reductase B2, mitochondrial
    Protein Accession:
    Q9Y3D2
    Secondary Accessions:
    • Q17R44
    • Q4G1C7
    • Q9Y5W6

    Protein attributes for MSRB2 Gene

    Size:
    182 amino acids
    Molecular mass:
    19536 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34126.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MSRB2 Gene

Proteomics data for MSRB2 Gene at MOPED

Selected DME Specific Peptides for MSRB2 Gene

Post-translational modifications for MSRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MSRB2 Gene

Protein Domains for MSRB2 Gene

Suggested Antigen Peptide Sequences for MSRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D2

UniProtKB/Swiss-Prot:

MSRB2_HUMAN :
  • Q9Y3D2
Family:
  • Belongs to the MsrB Met sulfoxide reductase family.
genes like me logo Genes that share domains with MSRB2: view

No data available for Gene Families for MSRB2 Gene

Function for MSRB2 Gene

Molecular function for MSRB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin
UniProtKB/Swiss-Prot Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.

Enzyme Numbers (IUBMB) for MSRB2 Gene

Gene Ontology (GO) - Molecular Function for MSRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10375640
GO:0003779 actin binding ISS --
GO:0008270 zinc ion binding ISS 14699060
GO:0033743 peptide-methionine (R)-S-oxide reductase activity ISS --
genes like me logo Genes that share ontologies with MSRB2: view

Phenotypes for MSRB2 Gene

GenomeRNAi human phenotypes for MSRB2:
genes like me logo Genes that share phenotypes with MSRB2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSRB2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MSRB2 Gene

Localization for MSRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSRB2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSRB2 Gene COMPARTMENTS Subcellular localization image for MSRB2 gene
Compartment Confidence
mitochondrion 5
chloroplast 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MSRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS 14699060
genes like me logo Genes that share ontologies with MSRB2: view

Pathways for MSRB2 Gene

SuperPathways for MSRB2 Gene

No Data Available

Interacting Proteins for MSRB2 Gene

Gene Ontology (GO) - Biological Process for MSRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 10375640
GO:0006979 response to oxidative stress IEA --
GO:0030041 actin filament polymerization ISS --
GO:0030091 protein repair ISS 14699060
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MSRB2: view

No data available for Pathways by source for MSRB2 Gene

Compounds for MSRB2 Gene

(1) HMDB Compounds for MSRB2 Gene

Compound Synonyms Cas Number PubMed IDs
Methionine sulfoxide
  • DL-Methionine sulfoxide
62697-73-8

(1) Drugbank Compounds for MSRB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Methionine
  • (S)-2-amino-4-(methylthio)butanoic acid
63-68-3 enzyme substrate

(8) Novoseek inferred chemical compound relationships for MSRB2 Gene

Compound -log(P) Hits PubMed IDs
methionine sulfoxide 97.5 31
methionine 81.6 15
sulfoxide 79 6
cysteine 42.2 1
oxygen 36.7 4
genes like me logo Genes that share compounds with MSRB2: view

Transcripts for MSRB2 Gene

mRNA/cDNA for MSRB2 Gene

Unigene Clusters for MSRB2 Gene

Methionine sulfoxide reductase B2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSRB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSRB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3:

Relevant External Links for MSRB2 Gene

GeneLoc Exon Structure for
MSRB2
ECgene alternative splicing isoforms for
MSRB2

Expression for MSRB2 Gene

mRNA expression in normal human tissues for MSRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSRB2 Gene

This gene is overexpressed in Heart - Left Ventricle (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MSRB2 Gene

SOURCE GeneReport for Unigene cluster for MSRB2 Gene Hs.461420

mRNA Expression by UniProt/SwissProt for MSRB2 Gene

Q9Y3D2-MSRB2_HUMAN
Tissue specificity: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate.
genes like me logo Genes that share expressions with MSRB2: view

In Situ Assay Products

Orthologs for MSRB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MSRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSRB2 35
  • 99.31 (n)
  • 99.31 (a)
MSRB2 36
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSRB2 35
  • 80.77 (n)
  • 82.42 (a)
MSRB2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSRB2 35
  • 84.26 (n)
  • 85 (a)
MSRB2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msrb2 35
  • 81.02 (n)
  • 83.33 (a)
Msrb2 16
Msrb2 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSRB2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSRB2 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msrb2 35
  • 81.71 (n)
  • 85.42 (a)
lizard
(Anolis carolinensis)
Reptilia MSRB2 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22830 35
tropical clawed frog
(Silurana tropicalis)
Amphibia msrb2 35
  • 69.48 (n)
  • 73.24 (a)
Str.15443 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5765 35
zebrafish
(Danio rerio)
Actinopterygii msrb2 35
  • 66.92 (n)
  • 74.62 (a)
msrb2 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F44E2.6 35
  • 52.12 (n)
  • 48.41 (a)
F44E2.6 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MXR2 36
  • 33 (a)
OneToMany
Species with no ortholog for MSRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSRB2 Gene

ENSEMBL:
Gene Tree for MSRB2 (if available)
TreeFam:
Gene Tree for MSRB2 (if available)

Paralogs for MSRB2 Gene

Paralogs for MSRB2 Gene

Selected SIMAP similar genes for MSRB2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MSRB2: view

Variants for MSRB2 Gene

Sequence variations from dbSNP and Humsavar for MSRB2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7427 -- 23,119,349(+) TTTTC(C/T)GAGGC reference, synonymous-codon
rs15404 -- 23,120,880(-) GGGAA(C/T)GGGAC utr-variant-3-prime
rs967483 -- 23,116,979(-) taccc(C/T)ctccc intron-variant
rs1001165 -- 23,099,982(-) CTGTC(C/G)TTAGT intron-variant
rs1555800 -- 23,096,721(+) CCAAC(A/T)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSRB2 Gene

Variant ID Type Subtype PubMed ID
esv2734017 CNV Deletion 23290073
nsv25129 CNV Loss 16902084
esv987760 CNV Deletion 20482838
esv1381341 CNV Deletion 17803354

Relevant External Links for MSRB2 Gene

HapMap Linkage Disequilibrium report
MSRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSRB2 Gene

Disorders for MSRB2 Gene

Relevant External Links for MSRB2

Genetic Association Database (GAD)
MSRB2
Human Genome Epidemiology (HuGE) Navigator
MSRB2
genes like me logo Genes that share disorders with MSRB2: view

No data available for UniProtKB/Swiss-Prot for MSRB2 Gene

Publications for MSRB2 Gene

  1. Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases. (PMID: 10375640) Huang W. … Coca-Prados M. (Gene 1999) 2 3 4 23
  2. Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. (PMID: 18424444) Cabreiro F. … Petropoulos I. (J. Biol. Chem. 2008) 3 4 23
  3. Differential expression of the antioxidant repair enzyme methionine sulfoxide reductase (MSRA and MSRB) in human skin. (PMID: 19542914) Taungjaruwinai W.M. … Thiele J.J. (Am J Dermatopathol 2009) 3 23
  4. Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins. (PMID: 8749308) Escribano J. … Coca-Prados M. (J. Biochem. 1995) 2 3
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4

Products for MSRB2 Gene

Sources for MSRB2 Gene

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