Aliases for MSRB1 Gene
External Ids for MSRB1 Gene
Previous HGNC Symbols for MSRB1 Gene
Previous GeneCards Identifiers for MSRB1 Gene
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes to the cell nucleus and cytosol. [provided by RefSeq, Mar 2012]
GeneCards Summary for MSRB1 Gene
MSRB1 (Methionine Sulfoxide Reductase B1) is a Protein Coding gene. Diseases associated with MSRB1 include alzheimer disease mitochondrial. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway. GO annotations related to this gene include actin binding and methionine-R-sulfoxide reductase activity.
UniProtKB/Swiss-Prot for MSRB1 Gene
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity).