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Aliases for MSRB1 Gene

Aliases for MSRB1 Gene

  • Methionine Sulfoxide Reductase B1 2 3 5
  • Selenoprotein X, 1 2 3
  • SEPX1 3 4
  • SELX 3 4
  • Selenoprotein R 3
  • Selenoprotein X 4
  • EC 1.8.4.- 4
  • HSPC270 3
  • MsrB1 4
  • SELR 3
  • SepR 3

External Ids for MSRB1 Gene

Previous HGNC Symbols for MSRB1 Gene

  • SEPX1

Previous GeneCards Identifiers for MSRB1 Gene

  • GC16M001995
  • GC16M001997
  • GC16M001999
  • GC16M002001

Summaries for MSRB1 Gene

Entrez Gene Summary for MSRB1 Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes to the cell nucleus and cytosol. [provided by RefSeq, Mar 2012]

GeneCards Summary for MSRB1 Gene

MSRB1 (Methionine Sulfoxide Reductase B1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Selenium Pathway. GO annotations related to this gene include actin binding and methionine-R-sulfoxide reductase activity.

UniProtKB/Swiss-Prot for MSRB1 Gene

  • Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity).

Gene Wiki entry for MSRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSRB1 Gene

Genomics for MSRB1 Gene

Regulatory Elements for MSRB1 Gene

Promoters for MSRB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MSRB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MSRB1 Gene

Chromosome:
16
Start:
1,938,210 bp from pter
End:
1,943,326 bp from pter
Size:
5,117 bases
Orientation:
Minus strand

Genomic View for MSRB1 Gene

Genes around MSRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSRB1 Gene

Proteins for MSRB1 Gene

  • Protein details for MSRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZV6-MSRB1_HUMAN
    Recommended name:
    Methionine-R-sulfoxide reductase B1
    Protein Accession:
    Q9NZV6
    Secondary Accessions:
    • Q96RX6
    • Q9BTV2
    • Q9P0B1

    Protein attributes for MSRB1 Gene

    Size:
    116 amino acids
    Molecular mass:
    12760 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28948.1; Type=Erroneous termination; Positions=95; Note=Translated as Sec.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MSRB1 Gene

neXtProt entry for MSRB1 Gene

Proteomics data for MSRB1 Gene at MOPED

Post-translational modifications for MSRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSRB1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for MSRB1

No data available for DME Specific Peptides for MSRB1 Gene

Domains & Families for MSRB1 Gene

Protein Domains for MSRB1 Gene

Suggested Antigen Peptide Sequences for MSRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZV6

UniProtKB/Swiss-Prot:

MSRB1_HUMAN :
  • Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.
  • Belongs to the MsrB Met sulfoxide reductase family.
Domain:
  • Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.
Family:
  • Belongs to the MsrB Met sulfoxide reductase family.
genes like me logo Genes that share domains with MSRB1: view

No data available for Gene Families for MSRB1 Gene

Function for MSRB1 Gene

Molecular function for MSRB1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.
UniProtKB/Swiss-Prot Function:
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity).

Enzyme Numbers (IUBMB) for MSRB1 Gene

genes like me logo Genes that share phenotypes with MSRB1: view

Animal Models for MSRB1 Gene

MGI Knock Outs for MSRB1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MSRB1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSRB1 Gene

Localization for MSRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSRB1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSRB1 Gene COMPARTMENTS Subcellular localization image for MSRB1 gene
Compartment Confidence
cytosol 5
nucleus 4
chloroplast 2
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MSRB1 Gene

Pathways & Interactions for MSRB1 Gene

genes like me logo Genes that share pathways with MSRB1: view

Pathways by source for MSRB1 Gene

2 BioSystems pathways for MSRB1 Gene
2 Reactome pathways for MSRB1 Gene

Interacting Proteins for MSRB1 Gene

Gene Ontology (GO) - Biological Process for MSRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with MSRB1: view

No data available for SIGNOR curated interactions for MSRB1 Gene

Drugs & Compounds for MSRB1 Gene

(10) Drugs for MSRB1 Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Methionine Approved Nutra Enzyme, substrate 0
Selenocysteine Experimental Pharma 0
Selenium Pharma 166

(3) Additional Compounds for MSRB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSRB1: view

Transcripts for MSRB1 Gene

Unigene Clusters for MSRB1 Gene

Methionine sulfoxide reductase B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSRB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for MSRB1 Gene

GeneLoc Exon Structure for
MSRB1
ECgene alternative splicing isoforms for
MSRB1

Expression for MSRB1 Gene

mRNA expression in normal human tissues for MSRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSRB1 Gene

This gene is overexpressed in Whole Blood (x24.9).

Protein differential expression in normal tissues from HIPED for MSRB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (62.0) and Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MSRB1 Gene



SOURCE GeneReport for Unigene cluster for MSRB1 Gene Hs.655346

genes like me logo Genes that share expression patterns with MSRB1: view

Protein tissue co-expression partners for MSRB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MSRB1 Gene

Orthologs for MSRB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPX1 36
  • 98 (a)
OneToOne
SEPX1 35
  • 99.42 (n)
  • 98.25 (a)
cow
(Bos Taurus)
Mammalia SEPX1 35
  • 86.78 (n)
  • 90.52 (a)
dog
(Canis familiaris)
Mammalia SEPX1 35
  • 87.43 (n)
  • 92.98 (a)
mouse
(Mus musculus)
Mammalia Msrb1 36
  • 91 (a)
OneToOne
Msrb1 16
Msrb1 35
  • 86.78 (n)
  • 91.38 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MSRB1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msrb1 35
  • 86.67 (n)
  • 93.04 (a)
chicken
(Gallus gallus)
Aves MSRB1 35
  • 83.33 (n)
  • 89.62 (a)
MSRB1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSRB1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msrb1 35
  • 69.35 (n)
  • 75 (a)
Str.3291 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.650 35
zebrafish
(Danio rerio)
Actinopterygii msrb1a 36
  • 57 (a)
OneToMany
msrb1b 36
  • 69 (a)
OneToMany
msrb1a 35
  • 72.33 (n)
  • 79.25 (a)
sepx1 35
Species with no ortholog for MSRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSRB1 Gene

ENSEMBL:
Gene Tree for MSRB1 (if available)
TreeFam:
Gene Tree for MSRB1 (if available)

Paralogs for MSRB1 Gene

(2) SIMAP similar genes for MSRB1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MSRB1 Gene

genes like me logo Genes that share paralogs with MSRB1: view

No data available for Paralogs for MSRB1 Gene

Variants for MSRB1 Gene

Sequence variations from dbSNP and Humsavar for MSRB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs732510 -- 1,943,476(+) CCCCT(A/G)GGCCG upstream-variant-2KB
rs2531329 -- 1,943,828(+) TCTTT(C/T)GAGAC upstream-variant-2KB
rs2999971 -- 1,939,107(+) GGCTG(A/C)CCGCC utr-variant-3-prime
rs2999972 -- 1,939,172(+) AAAGT(A/C)TGCGG intron-variant
rs2999973 -- 1,942,906(+) CTCCT(A/C)GGGTA intron-variant

Variation tolerance for MSRB1 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSRB1 Gene

HapMap Linkage Disequilibrium report
MSRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MSRB1 Gene

Disorders for MSRB1 Gene

Relevant External Links for MSRB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSRB1

No disorders were found for MSRB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSRB1 Gene

Publications for MSRB1 Gene

  1. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. (PMID: 10608886) Lescure A. … Krol A. (J. Biol. Chem. 1999) 2 3 4 67
  2. Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases. (PMID: 16542431) Kim H.Y. … Gladyshev V.N. (BMC Mol. Biol. 2006) 23 25 26
  3. Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing. (PMID: 20634897) Liang X. … Gladyshev V.N. (PLoS ONE 2010) 2 3
  4. Neutrophil granulocytes uniquely express, among human blood cells, high levels of Methionine-sulfoxide-reductase enzymes. (PMID: 17938273) Achilli C. … Minetti G. (J. Leukoc. Biol. 2008) 3 23
  5. Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia. (PMID: 18081029) Kakiuchi C. … Kato T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23

Products for MSRB1 Gene

Sources for MSRB1 Gene

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