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MSRB1 Gene

protein-coding   GIFtS: 47
GCID: GC16M002001

Methionine Sulfoxide Reductase B1

(Previous names: selenoprotein X, 1)
(Previous symbol: SEPX1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Methionine Sulfoxide Reductase B11 2     Methionine-R-Sulfoxide Reductase B12
SEPX11 2 3 5     Selenoprotein R2
Selenoprotein X, 11 2     EC 1.8.4.-3
SELX2 5     MsrB13
SELR2     SelX3
SepR2     Selenoprotein X3

External Ids:    HGNC: 141331   Entrez Gene: 517342   Ensembl: ENSG000001987367   OMIM: 6062165   UniProtKB: Q9NZV63   

Export aliases for MSRB1 gene to outside databases

Previous GC identifers: GC16M001995 GC16M001997 GC16M001999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSRB1 Gene:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The
selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of
selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for
the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine
sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues
in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes
to the cell nucleus and cytosol. (provided by RefSeq, Mar 2012)

GeneCards Summary for MSRB1 Gene:
MSRB1 (methionine sulfoxide reductase B1) is a protein-coding gene. Diseases associated with MSRB1 include cataract, and ischemia. GO annotations related to this gene include methionine-R-sulfoxide reductase activity and actin binding.

UniProtKB/Swiss-Prot: MSRB1_HUMAN, Q9NZV6
Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine.
While in many cases, methionine oxidation is the result of random oxidation following oxidative stress,
methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a
regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on
actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin,
leading to actin repolymerization in macrophages (By similarity)

Gene Wiki entry for MSRB1 (SEPX1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MSRB1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSRB1 promoter sequence
   Search Chromatin IP Primers for MSRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MSRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSRB1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002001:  view genomic region     (about GC identifiers)

Start:
1,988,211 bp from pter      End:
1,993,327 bp from pter
Size:
5,117 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MSRB1_HUMAN, Q9NZV6 (See protein sequence)
Recommended Name: Methionine-R-sulfoxide reductase B1  
Size: 116 amino acids; 12760 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Sequence caution: Sequence=AAF28948.1; Type=Erroneous termination; Positions=95; Note=Translated as Sec;
1 PDB 3D structure from and Proteopedia for MSRB1:
3MAO (3D)    
Secondary accessions: Q96RX6 Q9BTV2 Q9P0B1

Explore the universe of human proteins at neXtProt for MSRB1: NX_Q9NZV6

Explore proteomics data for MSRB1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MSRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057416.1  
    ENSEMBL proteins: 
     ENSP00000355084   ENSP00000457320   ENSP00000382657   ENSP00000456557  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002579 Met_Sox_Rdtase_MsrB
     IPR028427 Met_Sox_Rdtase
     IPR011057 Mss4-like

    Graphical View of Domain Structure for InterPro Entry Q9NZV6

    ProtoNet protein and cluster: Q9NZV6

    1 Blocks protein domain: IPB002579 Protein of unknown function DUF25

    UniProtKB/Swiss-Prot: MSRB1_HUMAN, Q9NZV6
    Similarity: Belongs to the MsrB Met sulfoxide reductase family


    MSRB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSRB1_HUMAN, Q9NZV6
    Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine.
    While in many cases, methionine oxidation is the result of random oxidation following oxidative stress,
    methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a
    regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on
    actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin,
    leading to actin repolymerization in macrophages (By similarity)
    Catalytic activity: L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin

         Enzyme Number (IUBMB): EC 1.8.4.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0008270zinc ion binding ISS14699060
    GO:0033743peptide-methionine (R)-S-oxide reductase activity ISS--
    GO:0070191methionine-R-sulfoxide reductase activity IEA--
         
    MSRB1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Msrb1):
     cellular  growth/size/body  mortality/aging 

    MSRB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Msrb1tm1.1Rlev for MSRB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSRB1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSRB1

    miRNA
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    miRTarBase miRNAs that target MSRB1:
    hsa-mir-149-5p (MIRT045669)

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    SwitchGear 3'UTR luciferase reporter plasmidMSRB1 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat MSRB1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MSRB1_HUMAN, Q9NZV6: Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm, cytoskeleton (By similarity)

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0015629colocalizes with actin cytoskeleton ISS--

    MSRB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MSRB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selenium Pathway
    Selenium Pathway
    2Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    2 BioSystems Pathways for MSRB1
        Selenium Metabolism and Selenoproteins
    Selenium Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSRB1
    Interactions:

        Search GeneGlobe Interaction Network for MSRB1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MSRB1 (ENSP000003550844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MSRAENSP000003139214STRING: ENSP00000313921
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress IEA--
    GO:0030041actin filament polymerization ISS--
    GO:0030091protein repair ISS14699060
    GO:0045087innate immune response ISS--
    GO:0055114oxidation-reduction process ----

    MSRB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSRB1

    Selected Novoseek inferred chemical compound relationships for MSRB1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methionine sulfoxide 98.6 125 19373970 (3), 17418992 (3), 16735467 (2), 18302927 (2) (see all 78)
    methionine 82.6 28 17180746 (1), 18302927 (1), 19406207 (1), 16542431 (1) (see all 22)
    sulfoxide 78.2 5 18302927 (1), 17938273 (1), 15680231 (1), 15280355 (1)
    selenocysteine 69.4 6 16262444 (1), 14699060 (1)
    cysteine 48.4 2 16262444 (1), 14580313 (1)
    oxygen 44 5 15680219 (1), 14699060 (1), 16684363 (1), 11084287 (1) (see all 5)
    h2o2 36.3 1 18206120 (1)
    selenium 36.1 1 15210302 (1)
    cholesterol 0 1 16497665 (1)
    calcium 0 2 11010965 (1), 19902913 (1)



    MSRB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MSRB1 gene: 
    NM_016332.2  

    Unigene Cluster for MSRB1:

    Methionine sulfoxide reductase B1
    Hs.655346  [show with all ESTs]
    Unigene Representative Sequence: BM548797
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361871(uc021tam.1) ENST00000473663 ENST00000399753 ENST00000564908
    ENST00000489198
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMSRB1 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for MSRB1
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      QuantiTect SYBR Green Assays in human, mouse, rat MSRB1
      QuantiFast Probe-based Assays in human, mouse, rat MSRB1

    Additional mRNA sequence: 

    AF161388.1 AF166124.1 AF187272.1 AK026128.1 BC003127.1 

    13 DOTS entries:

    DT.455004  DT.100812561  DT.100812559  DT.120704502  DT.95286963  DT.100705114  DT.100812564  DT.40115486 
    DT.86841265  DT.91749933  DT.99928998  DT.92433855  DT.99985022 

    24 AceView cDNA sequences:

    CR598886 CR614779 CR616027 AF166124 CR590497 AK026128 AF187272 BC003127 
    CR609793 NM_016332 BX397284 BX396802 AF161388 AV653651 BX449117 AA829291 
    AI348922 AW900908 CB148054 BF360519 BG315397 BF901731 AW856109 BG166852 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MSRB1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                    -                 -                           
    SP2:                    -           -     -                           
    SP3:                    -                                             
    SP4:                                                                  


    ECgene alternative splicing isoforms for MSRB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSRB1 expression in normal human tissues (normalized intensities)      MSRB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGGAGGCC
    MSRB1 Expression
    About this image


    MSRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    MSRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655346
        Custom PCR Arrays for MSRB1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSRB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MSRB1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msrb11 , 5 selenoprotein X 15
    methionine sulfoxide reductase B11
    86.78(n)1
    91.38(a)1
      17 (12.53 cM)5
    273611  NM_013759.21  NP_038787.11 
     247366425 
    chicken
    (Gallus gallus)
    Aves MSRB11 methionine sulfoxide reductase B1 83.33(n)
    89.62(a)
      416540  NM_001135558.1  NP_001129030.1 
    lizard
    (Anolis carolinensis)
    Reptilia MSRB16
    methionine sulfoxide reductase B1
    79(a)
    1 ↔ 1
    GL343263.1(2010380-2010505)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.32912 Transcribed sequence with moderate similarity to protein more 78.15(n)    142005048 
    zebrafish
    (Danio rerio)
    Actinopterygii sepx12 selenoprotein X, 1 77.22(n)   352916  BC061952.1 


    ENSEMBL Gene Tree for MSRB1 (if available)
    TreeFam Gene Tree for MSRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSRB1 gene
    2 SIMAP similar genes for MSRB1 using alignment to 4 protein entries:     MSRB1_HUMAN (see all proteins):
    SEPX1    MSRB3

    MSRB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MSRB1
    PGOHUM00000259330


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSRB1 (see all 165)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384649941,2
    --1987758(+) CCTCAC/TGTTGG 1 -- ds50010--------
    rs1864496711,2
    --1987854(+) GCCTGC/GCTTTT 1 -- ds50010--------
    rs1908780511,2
    --1987948(+) ACATGG/TGTAAT 1 -- ds50010--------
    rs1179640481,2
    --1987961(+) TAGCAT/CTTTGG 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1809733941,2
    --1988101(+) ACTTGA/GGAGGC 1 -- ds50010--------
    rs1113013111,2
    F--1988104(+) TGGGAA/GGCTGA 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1858517251,2
    --1988112(+) TGAGGC/TGGGAG 1 -- ds50010--------
    rs1909565141,2
    --1988120(+) GAGAAC/TCACTT 1 -- ds50010--------
    rs2013160301,2
    --1988215(+) AAAAC-/AAAAAA 1 -- ds50010--------
    rs761257341,2
    F--1988235(+) TACATC/GTGAAT 1 -- ut311Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for MSRB1 (1988211 - 1993327 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MSRB1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for MSRB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606216    OMIM disorders: --

    9 diseases for MSRB1:    About MalaCards
    cataract    ischemia    pneumonia    chronic lymphocytic leukemia
    parkinson's disease    schizophrenia    tuberculosis    alzheimer's disease
    leukemia


    MSRB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for MSRB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemia 0 2 16677789 (1), 15680220 (1)
    inflammation 0 1 15680220 (1)


    Export disorders for MSRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSRB1 gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with MSRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif. (PubMed id 10608886)1, 2, 3 Lescure A.... Krol A. (J. Biol. Chem. 1999)
    2. Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing. (PubMed id 20634897)1, 3 Liang X....Gladyshev V.N. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. (PubMed id 14699060)1, 9 Kim H.-Y. and Gladyshev V.N. (Mol. Biol. Cell 2004)
    7. Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia. (PubMed id 18081029)1, 9 Kakiuchi C....Kato T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    8. Neutrophil granulocytes uniquely express, among human blood cells, high levels of Methionine-sulfoxide-reductase enzymes. (PubMed id 17938273)1, 9 Achilli C....Minetti G. (J. Leukoc. Biol. 2008)
    9. Effect of methionine sulfoxide reductase B1 (SelR) gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells. (PubMed id 24342607)1 Jia Y....Huang K. (Biochem. Biophys. Res. Commun. 2014)
    10. Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosis of human lens epithelial cells. (PubMed id 23270945)1 Li Y....Huang K. (Life Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51734 HGNC: 14133 AceView: SEPX1 Ensembl:ENSG00000198736 euGenes: HUgn51734
    ECgene: MSRB1 H-InvDB: MSRB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSRB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSRB1 gene:
    Search GeneIP for patents involving MSRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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