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Aliases for MSRA Gene

Aliases for MSRA Gene

  • Methionine Sulfoxide Reductase A 2 3
  • Peptide-Methionine (S)-S-Oxide Reductase 3 4
  • Peptide Met(O) Reductase 3 4
  • EC 1.8.4.11 4 64
  • PMSR 3 4
  • Mitochondrial Peptide Methionine Sulfoxide Reductase 3
  • Cytosolic Methionine-S-Sulfoxide Reductase 3
  • Protein-Methionine-S-Oxide Reductase 4
  • Peptide Met (O) Reductase 3

External Ids for MSRA Gene

Summaries for MSRA Gene

Entrez Gene Summary for MSRA Gene

  • This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for MSRA Gene

MSRA (Methionine Sulfoxide Reductase A) is a Protein Coding gene. Diseases associated with MSRA include occult macular dystrophy and mycobacterium abscessus. GO annotations related to this gene include peptide-methionine (S)-S-oxide reductase activity.

UniProtKB/Swiss-Prot for MSRA Gene

  • Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

Gene Wiki entry for MSRA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSRA Gene

Genomics for MSRA Gene

Genomic Location for MSRA Gene

Start:
10,054,268 bp from pter
End:
10,428,891 bp from pter
Size:
374,624 bases
Orientation:
Plus strand

Genomic View for MSRA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSRA Gene

Regulatory Elements for MSRA Gene

Proteins for MSRA Gene

  • Protein details for MSRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ68-MSRA_HUMAN
    Recommended name:
    Mitochondrial peptide methionine sulfoxide reductase
    Protein Accession:
    Q9UJ68
    Secondary Accessions:
    • E9PAS8
    • Q52TC4
    • Q549N4
    • Q66MI7

    Protein attributes for MSRA Gene

    Size:
    235 amino acids
    Molecular mass:
    26132 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSRA Gene

Proteomics data for MSRA Gene at MOPED

Post-translational modifications for MSRA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys181

Domains for MSRA Gene

Protein Domains for MSRA Gene

UniProtKB/Swiss-Prot:

MSRA_HUMAN
Family:
  • Belongs to the MsrA Met sulfoxide reductase family.:
    • Q9UJ68
genes like me logo Genes that share domains with MSRA: view

No data available for Gene Families for MSRA Gene

Function for MSRA Gene

Molecular function for MSRA Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin
UniProtKB/Swiss-Prot CatalyticActivity: L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin
UniProtKB/Swiss-Prot Function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

Enzyme Numbers (IUBMB) for MSRA Gene

Gene Ontology (GO) - Molecular Function for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008113 peptide-methionine (S)-S-oxide reductase activity IEA --
genes like me logo Genes that share ontologies with MSRA: view
genes like me logo Genes that share phenotypes with MSRA: view

Animal Models for MSRA Gene

MGI Knock Outs for MSRA:

miRNA for MSRA Gene

miRTarBase miRNAs that target MSRA

No data available for Transcription Factor Targeting and HOMER Transcription for MSRA Gene

Localization for MSRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSRA Gene

Isoform 1: Mitochondrion.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.
Isoform 5: Cytoplasm. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSRA Gene COMPARTMENTS Subcellular localization image for MSRA gene
Compartment Confidence
mitochondrion 5
nucleus 5
chloroplast 2
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with MSRA: view

Pathways for MSRA Gene

SuperPathways for MSRA Gene

No Data Available

Gene Ontology (GO) - Biological Process for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10452521
GO:0006555 methionine metabolic process TAS 10452521
GO:0006979 response to oxidative stress IEA --
GO:0030091 protein repair IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MSRA: view

No data available for Pathways by source for MSRA Gene

Compounds for MSRA Gene

(1) HMDB Compounds for MSRA Gene

Compound Synonyms Cas Number PubMed IDs
Methionine sulfoxide
  • DL-Methionine sulfoxide
62697-73-8

(2) Drugbank Compounds for MSRA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1,4-Dithiothreitol
target
L-Methionine
  • (S)-2-amino-4-(methylthio)butanoic acid
63-68-3 enzyme substrate

(15) Novoseek inferred chemical compound relationships for MSRA Gene

Compound -log(P) Hits PubMed IDs
methionine sulfoxide 98.6 105
methionine 83.6 42
sulfoxide 76.3 8
dihydrolipoic acid 67.1 3
oxygen 47.2 10
genes like me logo Genes that share compounds with MSRA: view

Transcripts for MSRA Gene

Unigene Clusters for MSRA Gene

Methionine sulfoxide reductase A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSRA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6:

Relevant External Links for MSRA Gene

GeneLoc Exon Structure for
MSRA
ECgene alternative splicing isoforms for
MSRA

Expression for MSRA Gene

mRNA expression in normal human tissues for MSRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSRA Gene

This gene is overexpressed in Kidney - Cortex (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSRA Gene

SOURCE GeneReport for Unigene cluster for MSRA Gene Hs.490981

mRNA Expression by UniProt/SwissProt for MSRA Gene

Q9UJ68-MSRA_HUMAN
Tissue specificity: Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus
genes like me logo Genes that share expressions with MSRA: view

Orthologs for MSRA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSRA 36
  • 99.43 (n)
  • 98.72 (a)
MSRA 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSRA 36
  • 87.84 (n)
  • 88.84 (a)
MSRA 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC608103 36
  • 88.41 (n)
  • 87.55 (a)
MSRA 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msra 36
  • 82.55 (n)
  • 86.27 (a)
Msra 16
Msra 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSRA 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSRA 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msra 36
  • 81.97 (n)
  • 85.84 (a)
chicken
(Gallus gallus)
Aves MSRA 36
  • 74.78 (n)
  • 79.13 (a)
MSRA 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSRA 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia msra-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia msra.1 36
  • 65.52 (n)
  • 61.21 (a)
zebrafish
(Danio rerio)
Actinopterygii MSRA 37
  • 64 (a)
OneToOne
si:dkey-221h15.1 36
  • 65.77 (n)
  • 69.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eip71CD 37
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea msra-1 37
  • 27 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR239W 36
  • 48.48 (n)
  • 38.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MXR1 37
  • 30 (a)
OneToOne
MXR1 39
rice
(Oryza sativa)
Liliopsida Os04g0482000 36
  • 54.5 (n)
  • 50.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6485 37
  • 58 (a)
OneToOne
Species with no ortholog for MSRA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSRA Gene

ENSEMBL:
Gene Tree for MSRA (if available)
TreeFam:
Gene Tree for MSRA (if available)

Paralogs for MSRA Gene

No data available for Paralogs for MSRA Gene

Variants for MSRA Gene

Sequence variations from dbSNP and Humsavar for MSRA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs14879 -- 10,428,763(+) AAGGG(A/G)CTTTC utr-variant-3-prime
rs472514 -- 10,059,382(+) ggccc(A/G)tagat intron-variant
rs476725 -- 10,062,665(-) GCACT(A/G)TGCTC intron-variant
rs497643 -- 10,059,812(+) gcaag(A/G)tagac intron-variant
rs530512 -- 10,061,106(+) CTGGG(A/T)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSRA Gene

Variant ID Type Subtype PubMed ID
nsv890343 CNV Gain 21882294
nsv831230 CNV Gain+Loss 17160897
nsv510128 CNV Loss 20534489
nsv890344 CNV Loss 21882294
nsv831231 CNV Gain 17160897
esv2524854 CNV Insertion 19546169
esv1116859 CNV Insertion 17803354
esv2016675 CNV Deletion 18987734
esv3698 CNV Deletion 18987735
esv2736590 CNV Deletion 23290073
nsv516061 CNV Loss 19592680
nsv890345 CNV Loss 21882294
nsv890346 CNV Loss 21882294
esv2659013 CNV Deletion 23128226
esv2666839 CNV Deletion 23128226
esv268529 CNV Insertion 20981092
nsv6078 CNV Insertion 18451855
nsv890347 CNV Loss 21882294
nsv518309 CNV Loss 19592680
esv2670330 CNV Deletion 23128226
nsv527326 CNV Gain 19592680
nsv890348 CNV Loss 21882294

Relevant External Links for MSRA Gene

HapMap Linkage Disequilibrium report
MSRA

Disorders for MSRA Gene

(1) University of Copenhagen DISEASES for MSRA Gene

(3) Novoseek inferred disease relationships for MSRA Gene

Disease -log(P) Hits PubMed IDs
cataract 22.1 7
atherosclerosis 0 1
alzheimers disease 0 3

Relevant External Links for MSRA

Genetic Association Database (GAD)
MSRA
Human Genome Epidemiology (HuGE) Navigator
MSRA
genes like me logo Genes that share disorders with MSRA: view

No data available for UniProtKB/Swiss-Prot for MSRA Gene

Publications for MSRA Gene

  1. Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA). (PMID: 10452521) Kuschel L. … Heinemann S.H. (FEBS Lett. 1999) 2 3 4 23
  2. Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina. (PMID: 16364291) Lee J.W. … Rodriguez I.R. (Exp. Eye Res. 2006) 3 4 23
  3. Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. (PMID: 15680232) Hansel A. … Hoshi T. (Biochim. Biophys. Acta 2005) 3 4 23
  4. Methionine sulfoxide reductase: a novel schizophrenia candidate gene. (PMID: 18506707) Walss-Bass C. … Raventos H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 49
  5. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. (PMID: 20421936) Scherag A. … Meyre D. (PLoS Genet. 2010) 3 23 49

Products for MSRA Gene

Sources for MSRA Gene

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