Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MSRA Gene

Aliases for MSRA Gene

  • Methionine Sulfoxide Reductase A 2 3 5
  • Peptide-Methionine (S)-S-Oxide Reductase 3 4
  • Peptide Met(O) Reductase 3 4
  • EC 4 56
  • PMSR 3 4
  • Mitochondrial Peptide Methionine Sulfoxide Reductase 3
  • Cytosolic Methionine-S-Sulfoxide Reductase 3
  • Protein-Methionine-S-Oxide Reductase 4
  • Peptide Met (O) Reductase 3

External Ids for MSRA Gene

Previous GeneCards Identifiers for MSRA Gene

  • GC08P009828
  • GC08P009949
  • GC08P008840

Summaries for MSRA Gene

Entrez Gene Summary for MSRA Gene

  • This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for MSRA Gene

MSRA (Methionine Sulfoxide Reductase A) is a Protein Coding gene. Diseases associated with MSRA include Mycobacterium Abscessus and Occult Macular Dystrophy. Among its related pathways are Protein repair and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include peptide-methionine (S)-S-oxide reductase activity.

UniProtKB/Swiss-Prot for MSRA Gene

  • Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Gene Wiki entry for MSRA Gene

Additional gene information for MSRA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSRA Gene

Genomics for MSRA Gene

GeneHancer (GH) Regulatory Elements for MSRA Gene

Promoters and enhancers for MSRA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I010053 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.4 412 2.3 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 POLR2B GLIS2 ELK1 ENSG00000260093 MSRA LOC105379234 LOC105379235
GH08I010095 Promoter 0.5 EPDnew 550.3 +41.5 41467 0.1 MSRA GC08M010081 LOC100420053
GH08I010096 Promoter 0.5 EPDnew 550.3 +41.2 41230 0.1 MSRA GC08M010081 LOC100420053
GH08I010332 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 31.5 +280.9 280897 5.3 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF48 GLIS2 ZNF143 RUNX3 YY2 MSRA ENSG00000255310 ENSG00000269918 ENSG00000272505 PRSS51 LOC100420053 GC08M010081
GH08I009933 Enhancer 1.1 FANTOM5 ENCODE 18.3 -120.5 -120529 0.8 PKNOX1 KLF17 ZNF76 SIN3A ZBTB40 ZNF143 KLF7 KLF13 EGR2 SP3 MSRA LINC00599 LOC105379234
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MSRA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MSRA gene promoter:

Genomic Locations for MSRA Gene

Genomic Locations for MSRA Gene
374,668 bases
Plus strand

Genomic View for MSRA Gene

Genes around MSRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSRA Gene

Proteins for MSRA Gene

  • Protein details for MSRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial peptide methionine sulfoxide reductase
    Protein Accession:
    Secondary Accessions:
    • E9PAS8
    • Q52TC4
    • Q549N4
    • Q66MI7

    Protein attributes for MSRA Gene

    235 amino acids
    Molecular mass:
    26132 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSRA Gene


neXtProt entry for MSRA Gene

Selected DME Specific Peptides for MSRA Gene


Post-translational modifications for MSRA Gene

  • Ubiquitination at isoforms=2, 3, 4, 5181

Domains & Families for MSRA Gene

Gene Families for MSRA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MSRA Gene

Suggested Antigen Peptide Sequences for MSRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MsrA Met sulfoxide reductase family.
  • Belongs to the MsrA Met sulfoxide reductase family.
genes like me logo Genes that share domains with MSRA: view

Function for MSRA Gene

Molecular function for MSRA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
UniProtKB/Swiss-Prot CatalyticActivity:
L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
UniProtKB/Swiss-Prot Function:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Enzyme Numbers (IUBMB) for MSRA Gene

Phenotypes From GWAS Catalog for MSRA Gene

Gene Ontology (GO) - Molecular Function for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008113 peptide-methionine (S)-S-oxide reductase activity IEA,TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MSRA: view
genes like me logo Genes that share phenotypes with MSRA: view

Animal Models for MSRA Gene

MGI Knock Outs for MSRA:

Animal Model Products

miRNA for MSRA Gene

miRTarBase miRNAs that target MSRA

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSRA Gene

Localization for MSRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSRA Gene

Isoform 1: Mitochondrion.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.
Isoform 5: Cytoplasm. Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSRA gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with MSRA: view

Pathways & Interactions for MSRA Gene

genes like me logo Genes that share pathways with MSRA: view

Pathways by source for MSRA Gene

1 BioSystems pathway for MSRA Gene
2 Reactome pathways for MSRA Gene

Gene Ontology (GO) - Biological Process for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10452521
GO:0006555 methionine metabolic process TAS 10452521
GO:0006979 response to oxidative stress TAS 10452521
GO:0030091 protein repair TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MSRA: view

No data available for SIGNOR curated interactions for MSRA Gene

Drugs & Compounds for MSRA Gene

(11) Drugs for MSRA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
methionine sulfoxide Experimental Pharma 0
1,4-Dithiothreitol Experimental Pharma Target 0

(7) Additional Compounds for MSRA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2S)-2-amino-4-(methylsulfanyl)butanoate
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
  • (L)-methionine
  • (S)-(+)-methionine
  • (S)-2-amino-4-(methylthio)-Butanoate
genes like me logo Genes that share compounds with MSRA: view

Transcripts for MSRA Gene

Unigene Clusters for MSRA Gene

Methionine sulfoxide reductase A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSRA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -

Relevant External Links for MSRA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MSRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSRA Gene

This gene is overexpressed in Kidney - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for MSRA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3), Liver, secretome (8.5), and Kidney (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSRA Gene

Protein tissue co-expression partners for MSRA Gene

NURSA nuclear receptor signaling pathways regulating expression of MSRA Gene:


SOURCE GeneReport for Unigene cluster for MSRA Gene:


mRNA Expression by UniProt/SwissProt for MSRA Gene:

Tissue specificity: Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus.

Evidence on tissue expression from TISSUES for MSRA Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Lung(4.2)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with MSRA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MSRA Gene

Orthologs for MSRA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSRA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MSRA 33 34
  • 99.43 (n)
(Canis familiaris)
Mammalia LOC608103 33
  • 88.41 (n)
  • 87 (a)
(Bos Taurus)
Mammalia MSRA 33 34
  • 87.84 (n)
(Mus musculus)
Mammalia Msra 33 16 34
  • 82.55 (n)
(Monodelphis domestica)
Mammalia MSRA 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Msra 33
  • 81.97 (n)
(Ornithorhynchus anatinus)
Mammalia MSRA 34
  • 79 (a)
(Gallus gallus)
Aves MSRA 33 34
  • 74.78 (n)
(Anolis carolinensis)
Reptilia MSRA 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia msra.1 33
  • 65.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia msra-prov 33
(Danio rerio)
Actinopterygii si:dkey-221h15.1 33
  • 65.77 (n)
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eip71CD 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea msra-1 34
  • 27 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR239W 33
  • 48.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MXR1 34 36
  • 30 (a)
(Oryza sativa)
Liliopsida Os04g0482000 33
  • 54.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6485 34
  • 58 (a)
Species where no ortholog for MSRA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSRA Gene

Gene Tree for MSRA (if available)
Gene Tree for MSRA (if available)

Paralogs for MSRA Gene

No data available for Paralogs for MSRA Gene

Variants for MSRA Gene

Sequence variations from dbSNP and Humsavar for MSRA Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000012237 -- 10,406,047(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000013843 -- 10,210,656(+) A/T intron_variant
rs1000014945 -- 10,329,484(+) C/T intron_variant
rs1000020221 -- 10,281,505(+) C/G/T intron_variant
rs1000026644 -- 10,142,729(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MSRA Gene

Variant ID Type Subtype PubMed ID
dgv11952n54 CNV loss 21841781
dgv1373e214 CNV loss 21293372
esv1116859 CNV insertion 17803354
esv2016675 CNV deletion 18987734
esv2524854 CNV insertion 19546169
esv2659013 CNV deletion 23128226
esv2666839 CNV deletion 23128226
esv2670330 CNV deletion 23128226
esv3304250 CNV mobile element insertion 20981092
esv3341433 CNV duplication 20981092
esv3410212 CNV insertion 20981092
esv3444107 CNV insertion 20981092
esv3572507 CNV loss 25503493
esv3616212 CNV loss 21293372
esv3616213 CNV loss 21293372
esv3616215 CNV loss 21293372
esv3616216 CNV loss 21293372
esv3616220 CNV loss 21293372
esv3616221 CNV gain 21293372
esv3616222 CNV loss 21293372
esv3616223 CNV loss 21293372
esv3616224 CNV loss 21293372
esv3616225 CNV loss 21293372
esv3616226 CNV loss 21293372
esv3698 CNV loss 18987735
nsv1018236 CNV loss 25217958
nsv1018940 CNV loss 25217958
nsv1025557 CNV gain 25217958
nsv1028650 CNV loss 25217958
nsv1030934 CNV gain 25217958
nsv1034343 CNV loss 25217958
nsv1077014 CNV deletion 25765185
nsv1137341 CNV deletion 24896259
nsv1151928 CNV deletion 26484159
nsv473889 CNV novel sequence insertion 20440878
nsv473916 CNV novel sequence insertion 20440878
nsv510128 OTHER sequence alteration 20534489
nsv516061 CNV loss 19592680
nsv518309 CNV loss 19592680
nsv527326 CNV gain 19592680
nsv6078 CNV insertion 18451855
nsv610263 CNV loss 21841781
nsv610264 CNV loss 21841781
nsv610267 CNV gain 21841781
nsv831230 CNV gain+loss 17160897
nsv831231 CNV gain 17160897
nsv972229 CNV deletion 23825009

Variation tolerance for MSRA Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSRA Gene

Disorders for MSRA Gene

MalaCards: The human disease database

(2) MalaCards diseases for MSRA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mycobacterium abscessus
  • m. abscessus
occult macular dystrophy
  • ocmd
- elite association - COSMIC cancer census association via MalaCards
Search MSRA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MSRA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MSRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSRA Gene

Publications for MSRA Gene

  1. Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA). (PMID: 10452521) Kuschel L … Heinemann SH (FEBS letters 1999) 2 3 4 22 58
  2. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. (PMID: 20421936) Scherag A … Meyre D (PLoS genetics 2010) 3 22 44 58
  3. Methionine sulfoxide reductase: a novel schizophrenia candidate gene. (PMID: 18506707) Walss-Bass C … Raventos H (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 44 58
  4. Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina. (PMID: 16364291) Lee JW … Rodriguez IR (Experimental eye research 2006) 3 4 22 58
  5. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PMID: 16480945) Schallreuter KU … Wood JM (Biochemical and biophysical research communications 2006) 3 22 25 58

Products for MSRA Gene

Sources for MSRA Gene

Loading form....