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Aliases for MSRA Gene

Aliases for MSRA Gene

  • Methionine Sulfoxide Reductase A 2 3 5
  • Peptide-Methionine (S)-S-Oxide Reductase 3 4
  • Peptide Met(O) Reductase 3 4
  • EC 1.8.4.11 4 61
  • PMSR 3 4
  • Mitochondrial Peptide Methionine Sulfoxide Reductase 3
  • Cytosolic Methionine-S-Sulfoxide Reductase 3
  • Protein-Methionine-S-Oxide Reductase 4
  • Peptide Met (O) Reductase 3

External Ids for MSRA Gene

Previous GeneCards Identifiers for MSRA Gene

  • GC08P009828
  • GC08P009949
  • GC08P008840

Summaries for MSRA Gene

Entrez Gene Summary for MSRA Gene

  • This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for MSRA Gene

MSRA (Methionine Sulfoxide Reductase A) is a Protein Coding gene. Diseases associated with MSRA include Mycobacterium Abscessus and Occult Macular Dystrophy. Among its related pathways are Protein repair and Metabolism of proteins. GO annotations related to this gene include peptide-methionine (S)-S-oxide reductase activity.

UniProtKB/Swiss-Prot for MSRA Gene

  • Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Gene Wiki entry for MSRA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSRA Gene

Genomics for MSRA Gene

Regulatory Elements for MSRA Gene

Enhancers for MSRA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F010332 1.6 FANTOM5 Ensembl ENCODE 31.5 +280.9 280897 5.3 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 GLIS2 CBX5 ZNF143 ZNF263 MSRA ENSG00000255310 ENSG00000269918 ENSG00000272505 PRSS51 LOC100420053 GC08M010081
GH08F009933 1.4 FANTOM5 Ensembl ENCODE 18.3 -120.5 -120489 0.9 PKNOX1 ZNF76 KLF17 ZBTB40 KLF7 EGR2 SP3 ZBTB11 NFYC ZNF518A MSRA LINC00599 MIR124-1 LOC105379234
GH08F010364 1.1 FANTOM5 Ensembl ENCODE 16.7 +311.3 311277 1.8 SMARCA4 POLR2A ZNF133 TEAD4 FOXP2 MSRA ENSG00000255310 ENSG00000269918 PIR43128 PIR53849
GH08F010151 1.1 Ensembl ENCODE 11.3 +98.0 97950 3.1 TBP RFX5 ZNF366 RCOR1 FOS CEBPB JUNB ZEB2 ZNF843 MYNN PINX1 MSRA ENSG00000269918 GC08M010081 LOC100420053
GH08F009945 0.5 FANTOM5 23.1 -108.9 -108850 0.2 ATF1 POLR2A MSRA MIR124-1 LINC00599 LOC105379234
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MSRA on UCSC Golden Path with GeneCards custom track

Promoters for MSRA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001385641 476 2201 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ELK1 ZNF143 MXD4

Genomic Location for MSRA Gene

Chromosome:
8
Start:
10,054,224 bp from pter
End:
10,428,891 bp from pter
Size:
374,668 bases
Orientation:
Plus strand

Genomic View for MSRA Gene

Genes around MSRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSRA Gene

Proteins for MSRA Gene

  • Protein details for MSRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ68-MSRA_HUMAN
    Recommended name:
    Mitochondrial peptide methionine sulfoxide reductase
    Protein Accession:
    Q9UJ68
    Secondary Accessions:
    • E9PAS8
    • Q52TC4
    • Q549N4
    • Q66MI7

    Protein attributes for MSRA Gene

    Size:
    235 amino acids
    Molecular mass:
    26132 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSRA Gene

Selected DME Specific Peptides for MSRA Gene

Q9UJ68:
  • PTYKEVC
  • FGMGCFW
  • GYCGLGG
  • QYRSAIY
  • LLKVFWE
  • FWENHDPTQGM
  • GCFWGAER
  • HDPTQGMRQG
  • KNPNGYC
  • AEDYHQQY
  • QGMRQGND
  • GTQYRSA

Post-translational modifications for MSRA Gene

  • Ubiquitination at Lys 181
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for MSRA Gene

Protein Domains for MSRA Gene

Suggested Antigen Peptide Sequences for MSRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJ68

UniProtKB/Swiss-Prot:

MSRA_HUMAN :
  • Belongs to the MsrA Met sulfoxide reductase family.
Family:
  • Belongs to the MsrA Met sulfoxide reductase family.
genes like me logo Genes that share domains with MSRA: view

No data available for Gene Families for MSRA Gene

Function for MSRA Gene

Molecular function for MSRA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
UniProtKB/Swiss-Prot CatalyticActivity:
L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
UniProtKB/Swiss-Prot Function:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Enzyme Numbers (IUBMB) for MSRA Gene

Gene Ontology (GO) - Molecular Function for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008113 peptide-methionine (S)-S-oxide reductase activity IEA,TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA --
genes like me logo Genes that share ontologies with MSRA: view
genes like me logo Genes that share phenotypes with MSRA: view

Animal Models for MSRA Gene

MGI Knock Outs for MSRA:

Animal Model Products

  • Taconic Biosciences Mouse Models for MSRA

miRNA for MSRA Gene

miRTarBase miRNAs that target MSRA

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSRA Gene

Localization for MSRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSRA Gene

Isoform 1: Mitochondrion.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.
Isoform 5: Cytoplasm. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSRA gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with MSRA: view

Pathways & Interactions for MSRA Gene

genes like me logo Genes that share pathways with MSRA: view

Pathways by source for MSRA Gene

1 BioSystems pathway for MSRA Gene
2 Reactome pathways for MSRA Gene

Gene Ontology (GO) - Biological Process for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10452521
GO:0006555 methionine metabolic process TAS 10452521
GO:0006979 response to oxidative stress IEA --
GO:0030091 protein repair IEA,TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MSRA: view

No data available for SIGNOR curated interactions for MSRA Gene

Drugs & Compounds for MSRA Gene

(12) Drugs for MSRA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Methionine Approved Nutra Enzyme, substrate 0
Water Approved Pharma 0
methionine sulfoxide Experimental Pharma 0
1,4-Dithiothreitol Experimental Pharma Target 0

(6) Additional Compounds for MSRA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSRA: view

Transcripts for MSRA Gene

Unigene Clusters for MSRA Gene

Methionine sulfoxide reductase A:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSRA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6:

Relevant External Links for MSRA Gene

GeneLoc Exon Structure for
MSRA
ECgene alternative splicing isoforms for
MSRA

Expression for MSRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MSRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSRA Gene

This gene is overexpressed in Kidney - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for MSRA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3), Liver, secretome (8.5), and Kidney (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSRA Gene



Protein tissue co-expression partners for MSRA Gene

NURSA nuclear receptor signaling pathways regulating expression of MSRA Gene:

MSRA

SOURCE GeneReport for Unigene cluster for MSRA Gene:

Hs.490981

mRNA Expression by UniProt/SwissProt for MSRA Gene:

Q9UJ68-MSRA_HUMAN
Tissue specificity: Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus.
genes like me logo Genes that share expression patterns with MSRA: view

Primer Products

Orthologs for MSRA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSRA 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia LOC608103 34
  • 88.41 (n)
MSRA 35
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSRA 34 35
  • 87.84 (n)
mouse
(Mus musculus)
Mammalia Msra 34 16 35
  • 82.55 (n)
oppossum
(Monodelphis domestica)
Mammalia MSRA 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msra 34
  • 81.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MSRA 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSRA 34 35
  • 74.78 (n)
lizard
(Anolis carolinensis)
Reptilia MSRA 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msra.1 34
  • 65.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia msra-prov 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-221h15.1 34
  • 65.77 (n)
MSRA 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip71CD 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea msra-1 35
  • 27 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR239W 34
  • 48.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MXR1 35 37
  • 30 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os04g0482000 34
  • 54.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6485 35
  • 58 (a)
OneToOne
Species where no ortholog for MSRA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSRA Gene

ENSEMBL:
Gene Tree for MSRA (if available)
TreeFam:
Gene Tree for MSRA (if available)

Paralogs for MSRA Gene

No data available for Paralogs for MSRA Gene

Variants for MSRA Gene

Sequence variations from dbSNP and Humsavar for MSRA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10081447 -- 10,057,770(+) TTCCT(C/T)TTCTG intron-variant, upstream-variant-2KB
rs10085917 -- 10,181,153(+) TAACC(A/T)GTAAG intron-variant
rs10086110 -- 10,163,366(+) TAAAC(A/G)GCACC intron-variant
rs10086721 -- 10,339,581(+) ctgtc(C/G)cccag intron-variant
rs10086826 -- 10,163,334(+) GTGGC(C/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSRA Gene

Variant ID Type Subtype PubMed ID
nsv972229 CNV deletion 23825009
nsv831231 CNV gain 17160897
nsv831230 CNV gain+loss 17160897
nsv610267 CNV gain 21841781
nsv610264 CNV loss 21841781
nsv610263 CNV loss 21841781
nsv6078 CNV insertion 18451855
nsv527326 CNV gain 19592680
nsv518309 CNV loss 19592680
nsv516061 CNV loss 19592680
nsv510128 OTHER sequence alteration 20534489
nsv473916 CNV novel sequence insertion 20440878
nsv473889 CNV novel sequence insertion 20440878
nsv1151928 CNV deletion 26484159
nsv1137341 CNV deletion 24896259
nsv1077014 CNV deletion 25765185
nsv1034343 CNV loss 25217958
nsv1030934 CNV gain 25217958
nsv1028650 CNV loss 25217958
nsv1025557 CNV gain 25217958
nsv1018940 CNV loss 25217958
nsv1018236 CNV loss 25217958
esv3698 CNV loss 18987735
esv3616226 CNV loss 21293372
esv3616225 CNV loss 21293372
esv3616224 CNV loss 21293372
esv3616223 CNV loss 21293372
esv3616222 CNV loss 21293372
esv3616221 CNV gain 21293372
esv3616220 CNV loss 21293372
esv3616216 CNV loss 21293372
esv3616215 CNV loss 21293372
esv3616213 CNV loss 21293372
esv3616212 CNV loss 21293372
esv3572507 CNV loss 25503493
esv3444107 CNV insertion 20981092
esv3410212 CNV insertion 20981092
esv3341433 CNV duplication 20981092
esv3304250 CNV mobile element insertion 20981092
esv2670330 CNV deletion 23128226
esv2666839 CNV deletion 23128226
esv2659013 CNV deletion 23128226
esv2524854 CNV insertion 19546169
esv2016675 CNV deletion 18987734
esv1116859 CNV insertion 17803354
dgv1373e214 CNV loss 21293372
dgv11952n54 CNV loss 21841781

Variation tolerance for MSRA Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSRA Gene

Disorders for MSRA Gene

MalaCards: The human disease database

(2) MalaCards diseases for MSRA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mycobacterium abscessus
  • m. abscessus
occult macular dystrophy
  • ocmd
- elite association - COSMIC cancer census association via MalaCards
Search MSRA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MSRA

Genetic Association Database (GAD)
MSRA
Human Genome Epidemiology (HuGE) Navigator
MSRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSRA
genes like me logo Genes that share disorders with MSRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSRA Gene

Publications for MSRA Gene

  1. Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA). (PMID: 10452521) Kuschel L. … Heinemann S.H. (FEBS Lett. 1999) 2 3 4 22 64
  2. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. (PMID: 20421936) Scherag A. … Meyre D. (PLoS Genet. 2010) 3 22 46 64
  3. Methionine sulfoxide reductase: a novel schizophrenia candidate gene. (PMID: 18506707) Walss-Bass C. … Raventos H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 22 46 64
  4. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PMID: 16480945) Schallreuter K.U. … Wood J.M. (Biochem. Biophys. Res. Commun. 2006) 3 22 25 64
  5. Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina. (PMID: 16364291) Lee J.W. … Rodriguez I.R. (Exp. Eye Res. 2006) 3 4 22 64

Products for MSRA Gene

  • Cloud-Clone Corp. Antibodies for MSRA
  • Cloud-Clone Corp. Proteins for MSRA
  • Cloud-Clone Corp Assay Kits for MSRA

Sources for MSRA Gene

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