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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSRA Gene

protein-coding   GIFtS: 59
GCID: GC08P009949

methionine sulfoxide reductase A
 Explore 25 diseases affiliated with
MSRA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MSRA    

Aliases
for MSRA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Methionine Sulfoxide Reductase A1 2     EC 1.8.4.113 8
Peptide Met(O) Reductase2 3     Cytosolic Methionine-S-Sulfoxide Reductase2
Peptide-Methionine (S)-S-Oxide Reductase2 3     Mitochondrial Peptide Methionine Sulfoxide Reductase2
Protein-Methionine-S-Oxide Reductase2 3     Peptide Met (O) Reductase2
PMSR2 3     Peptide Methionine Sulfoxide Reductase2

External Ids:    HGNC: 73771   Entrez Gene: 44822   Ensembl: ENSG000001758067   OMIM: 6012505   UniProtKB: Q9UJ683   

Export aliases for MSRA gene to outside databases

Previous GC identifers: GC08P009828 GC08P008840


Summaries
for MSRA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MSRA:
This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to
methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its
proposed function is the repair of oxidative damage to proteins to restore biological activity. Three transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: MSRA_HUMAN, Q9UJ68
Function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes
the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

Gene Wiki entry for MSRA


Genomic Views
for MSRA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_077531.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSRA gene promoter:
         Sox5   p53   AML1a   FOXF2   Pbx1a   RREB-1   LCR-F1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MSRA promoter sequence
   Search SABiosciences Chromatin IP Primers for MSRA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSRA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

MSRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSRA gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P009949:  view genomic region     (about GC identifiers)

Start:
 9,911,778 bp from pter      End:
 10,286,401 bp from pter
Size:
 374,624 bases      Orientation:
 plus strand

Proteins
for MSRA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MSRA_HUMAN, Q9UJ68 (See protein sequence)
Recommended Name: Mitochondrial peptide methionine sulfoxide reductase precursor  
Size: 235 amino acids; 26132 Da
Subcellular location: Isoform 1: Mitochondrion
Subcellular location: Isoform 2: Cytoplasm
Subcellular location: Isoform 3: Cytoplasm. Nucleus
Subcellular location: Isoform 5: Cytoplasm. Membrane; Lipid-anchor
Secondary accessions: E9PAS8 Q52TC4 Q549N4 Q66MI7
Alternative promoter usage, Alternative splicing, Alternative initiation: 5 isoforms:  Q9UJ68-1   Q9UJ68-2   Q9UJ68-3   Q9UJ68-4   Q9UJ68-5   (Cytoplasmic. Myristoylated at Gly-2. Produced by alternative initiation)

Explore the universe of human proteins at neXtProt for MSRA: NX_Q9UJ68

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UJ68

    • 4/12 DME Specific Peptides for MSRA (Q9UJ68) (see all 12)
     GYCGLGG  PTYKEVC  FGMGCFW  QYRSAIY 

    MSRA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129142.1  NP_001129143.1  NP_001186658.1  NP_036463.1  

    ENSEMBL proteins: 
     ENSP00000313921   ENSP00000410912   ENSP00000429461   ENSP00000435644   ENSP00000428214  
     ENSP00000436839   ENSP00000371930   ENSP00000427725  

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    Novus Biologicals MSRA Proteins
    Novus Biologicals MSRA Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MSRA
    Uscn Proteins for MSRA

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0016020membrane IEA--


    MSRA for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MSRA

    Protein Domains /
    Families
    for MSRA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MSRA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002569 Met_Sox_Rdtase_MsrA

    Graphical View of Domain Structure for InterPro Entry Q9UJ68

    ProtoNet protein and cluster: Q9UJ68

    1 Blocks protein family: IPB002569 Peptide methionine sulfoxide reductase

    UniProtKB/Swiss-Prot: MSRA_HUMAN, Q9UJ68
    Similarity: Belongs to the MsrA Met sulfoxide reductase family


    Function
    for MSRA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MSRA_HUMAN, Q9UJ68
    Function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes
    the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
    Catalytic activity: Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide +
    thioredoxin
    Catalytic activity: L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin

    Enzyme Number (IUBMB): EC 1.8.4.111 2

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MSRA

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008113peptide-methionine (S)-S-oxide reductase activity IEA--
    GO:0016671oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ----


    MSRA for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MSRA:
     Decreased influenza A/WSN/33 r  Decreased melanin production 

    Animal Models:
         Mouse knock-out Msratm1Jmo for MSRA
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Msra):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging 

    MSRA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MSRA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSRA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/15 Interacting proteins for MSRA (Q9UJ683 ENSP000003139214) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MSRB3Q8IXL73, ENSP000003473244I2D: score=2 STRING: ENSP00000347324
    TXNP105993, ENSP000003636414I2D: score=2 STRING: ENSP00000363641
    KIF3BO150663I2D: score=4 
    MAF1Q9H0633I2D: score=1 
    PPIBP232843I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10452521
    GO:0006555methionine metabolic process TAS10452521
    GO:0006979response to oxidative stress TAS10452521
    GO:0007568aging ----
    GO:0019538protein metabolic process ----


    MSRA for ontologies           About GeneDecksing



    Drugs & Compounds
    for MSRA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MSRA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSRA

    1 HMDB Compound for MSRA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Methionine sulfoxideDL-Methionine sulfoxide (see all 7)62697-73-8--

    2 DrugBank Compounds for MSRA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Methionine(S)-2-amino-4-(methylthio)butanoic acid (see all 6)63-68-3enzymesubstrate17126812 17624316 17031545 17500063 16480945
    1,4-Dithiothreitol-- --target--10592235

    10/15 Novoseek chemical compound relationships for MSRA gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methionine sulfoxide 98.6 175 15680234 (4), 19373970 (3), 18456002 (3), 17624653 (3) (see all 68)
    methionine 83.6 68 12837786 (3), 19646993 (2), 18456002 (2), 9275229 (2) (see all 35)
    sulfoxide 76.3 9 15820754 (1), 18302927 (1), 15516509 (1), 15680233 (1) (see all 8)
    dihydrolipoic acid 67.1 4 12215223 (2), 9541724 (1)
    oxygen 47.2 14 18456002 (2), 14980072 (1), 17180746 (1), 14699060 (1) (see all 9)
    fucoidan 46.8 2 9422792 (1), 9858512 (1)
    h2o2 45.6 13 9826655 (3), 19646993 (2), 19373970 (1), 9858512 (1) (see all 6)
    erythromycin 39.8 3 8463168 (1), 11020248 (1), 18769853 (1)
    cysteine 35.8 5 19646993 (1), 12837786 (1)
    alpha lipoic acid 31.5 2 12215223 (1)

    Search CenterWatch for drugs/clinical trials and news about MSRA 

    Transcripts
    for MSRA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MSRA gene (4 alternative transcripts): 
    NM_001135670.1  NM_001135671.1  NM_001199729.1  NM_012331.3  

    Unigene Cluster for MSRA:

    Methionine sulfoxide reductase A
    Hs.490981  [show with all ESTs]
    Unigene Representative Sequence: AK123132
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317173(uc003wsx.3 uc011kwx.2) ENST00000441698 ENST00000518255
    ENST00000521209 ENST00000522907 ENST00000528246(uc003wsy.3 uc003wsz.3)
    ENST00000523637(uc011kwy.1) ENST00000382490 ENST00000521686 ENST00000517594


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    hsa-miR-124 hsa-miR-506 hsa-miR-3175
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF086925.1 AF183420.1 AJ242973.1 AK123132.1 AK293488.1 AK299948.1 AY690665.1 AY958429.1 
    AY958430.1 AY958431.1 BC047552.1 BC054033.1 

    9 DOTS entries:

    DT.446987  DT.92037573  DT.100811779  DT.92003209  DT.95263940  DT.107462  DT.100688582  DT.40255207 
    DT.91993126 

    24/113 AceView cDNA sequences (see all 113):

    BX279881 AI521750 BX461653 CD516689 AI498302 CA389274 Z39699 CD365491 
    AL536061 AI133156 CK819754 BM141905 F06683 AI253074 BM720295 AF086925 
    BE552279 BU617637 BU853471 BC047552 CK300292 AI640600 CK430418 AI927862 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MSRA (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                      -                       -               
    SP2:        -     -     -                 -                       -               
    SP3:                    -                 -                       -               
    SP4:        -     -     -           -     -                                       
    SP5:              -     -                                                         


    ECgene alternative splicing isoforms for MSRA

    Expression
    for MSRA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSRA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGGCCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MSRA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSRA

    SOURCE GeneReport for Unigene cluster: Hs.490981

    UniProtKB/Swiss-Prot: MSRA_HUMAN, Q9UJ68
    Tissue specificity: Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles,
    bone marrow and hippocampus

        SABiosciences Expression via Pathway-Focused PCR Arrays including MSRA: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MSRA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MSRA gene from 11/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Msra1 , 5 methionine sulfoxide reductase A1, 5 82.55(n)1
    86.27(a)1    		   14 (33.36 cM)5
    1102651  NM_026322.41  NP_080598.21 
     641226235 
    chicken
    (Gallus gallus)    		 Aves MSRA1 methionine sulfoxide reductase A 74.93(n)
    79.13(a)    		   422027  XM_420035.3  XP_420035.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MSRA6
    		 --
    		 73(a)
    		 1 ↔ 1
    		 4(40666369-40928209)
    African clawed frog
    (Xenopus laevis)    		 Amphibia msra-prov2 methionine sulfoxide reductase A 78.08(n)    BC053804.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BQ449757.12   -- 77.94(n)    BQ449757.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eip71CD6
    		 Ecdysone-induced protein 28/29kD
    		 25(a)
    		 1 ↔ 1
    		 3L(15504152-15506302)
    worm
    (Caenorhabditis elegans)    		 Secernentea msra-16
    		 Protein MSRA-1
    		 25(a)
    		 1 ↔ 1
    		 II(7363173-7364064)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes MXR1(YER042W)4
    MXR11    		 Methionine-S-sulfoxide reductase, involved in the response more4
    Mxr1p1    		 44.51(n)1
    37.89(a)1    		   5(234937-235491)4
    8567651, 4  NP_010960.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PMSR11 peptide methionine sulfoxide reductase A1 53.29(n)
    48.3(a)    		   836286  NM_125558.2  NP_568937.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 peptide methionine sulfoxide reductase, putative, ...
    peptide methionine sulfoxide reductase, putative, ...
    (see all 4)    		 41(a)
    40(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 4(23917731-23919786)
    4(23923787-23924619)


    ENSEMBL Gene Tree for MSRA (if available)
    TreeFam Gene Tree for MSRA (if available) 

    Paralogs
    for MSRA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MSRA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9493 NCBI SNPs in MSRA are shown (see all 9493)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1453995291,2
    		--9909850(+) ATCTGA/CGGTGG 2 -- us2k10--------
    rs1492226641,2
    		--9909994(+) AAGTCC/TTAGTG 2 -- us2k10--------
    rs1912242021,2
    		--9910020(+) CTGAAA/GGCAAA 2 -- us2k10--------
    rs1833812141,2
    		--9910065(+) CTAATA/GTAACT 2 -- us2k10--------
    rs1884931341,2
    		--9910106(+) CCCTTC/GTTTTT 2 -- us2k10--------
    rs1434212941,2
    		--9910121(+) TAAGAC/TATATC 2 -- us2k10--------
    rs1479837391,2
    		--9910201(+) TAACAA/GTACAG 2 -- us2k10--------
    rs1453114081,2
    		C,--9910230(+) AAGAC-/AATG  
                AAAAG     		2 -- us2k10--------
    rs1915800791,2
    		--9910264(+) GAACAA/CAAAAA 2 -- us2k10--------
    rs1423939071,2
    		--9910346(+) ATACAC/TGCACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MSRA (9911778 - 10161778 bp, first 250kb of MSRA)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 21 variations for MSRA
         1 CNV: 23857
         4 Indels: 47418 41439 100268 52321
         15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MSRA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MSRA for disorders           About GeneDecksing

    OMIM gene information: 601250    OMIM disorders: --

    20/25 diseases for MSRA (see all 25):    About MalaCards
    mycobacterium abscessus    occult macular dystrophy    rheumatoid arthritis    macular dystrophy
    cataract    pulmonary fibrosis    alzheimer's disease    vitiligo
    hepatitis b    parkinson's disease    arthritis    atherosclerosis
    fibrosis    hepatocellular carcinoma    lung cancer    breast cancer
    ischemia    obesity    hepatitis    hypertension

    3 Novoseek disease relationships for MSRA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cataract 22.1 10 19461988 (4), 16934804 (1), 18588875 (1), 15199188 (1)
    atherosclerosis 0 1 10938019 (1)
    alzheimers disease 0 4 14663189 (2), 10501213 (1)

    Human Genome Epidemiology (HuGE) Navigator: MSRA (15 documents)

    Export disorders for MSRA gene to outside databases

    Publications
    for MSRA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSRA gene, integrated from 9 sources (see all 142):
    (articles sorted by number of sources associating them with MSRA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA). (PubMed id 10452521)1, 2, 3, 9 Kuschel L....Heinemann S.H. (1999)
    2. Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina. (PubMed id 16364291)1, 2, 9 Lee J.W.... Rodriguez I.R. (2006)
    3. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PubMed id 16480945)1, 7, 9 Schallreuter K.U....Wood J.M. (2006)
    4. Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. (PubMed id 15680232)1, 2, 9 Hansel A.... Hoshi T. (2005)
    5. Dual sites of protein initiation control the localiza tion and myristoylation of methionine sulfoxide reductase A. (PubMed id 20368336)1, 2 Kim G....Levine R.L. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins. (PubMed id 12039877)1, 2 Hansel A....Heinemann S.H. (2002)
    8. Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress. (PubMed id 15199188)1, 9 Kantorow M....Hejtmancik J.F. (2004)
    9. Methionine sulfoxide reductase: A novel schizophrenia candidate gene. (PubMed id 18506707)1, 9 Walss-Bass C....Raventos H. (2008)
    10. Autoantibody against one of the antioxidant repair en zymes, methionine sulfoxide reductase A, in systemic sclerosis: association wit h pulmonary fibrosis and vascular damage. (PubMed id 19844733)1, 9 Ogawa F....Sato S. (2010)

    External Searches for MSRA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MSRA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4482 HGNC: 7377 AceView: MSRA Ensembl:ENSG00000175806 euGenes: HUgn4482
    ECgene: MSRA H-InvDB: MSRA

    Other Databases showing MSRA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MSRA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSRA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSRA Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MSRA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MSRA gene:
    Search GeneIP for patents involving MSRA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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