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Aliases for MSRA Gene

Aliases for MSRA Gene

  • Methionine Sulfoxide Reductase A 2 3 5
  • Peptide-Methionine (S)-S-Oxide Reductase 3 4
  • Peptide Met(O) Reductase 3 4
  • EC 1.8.4.11 4 63
  • PMSR 3 4
  • Cytosolic Methionine-S-Sulfoxide Reductase 3
  • Protein-Methionine-S-Oxide Reductase 4
  • Peptide Met (O) Reductase 3

External Ids for MSRA Gene

Previous GeneCards Identifiers for MSRA Gene

  • GC08P009828
  • GC08P009949
  • GC08P008840

Summaries for MSRA Gene

Entrez Gene Summary for MSRA Gene

  • This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for MSRA Gene

MSRA (Methionine Sulfoxide Reductase A) is a Protein Coding gene. Diseases associated with MSRA include mycobacterium abscessus and occult macular dystrophy. Among its related pathways are Transport to the Golgi and subsequent modification and Protein repair. GO annotations related to this gene include peptide-methionine (S)-S-oxide reductase activity.

UniProtKB/Swiss-Prot for MSRA Gene

  • Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Gene Wiki entry for MSRA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSRA Gene

Genomics for MSRA Gene

Regulatory Elements for MSRA Gene

Promoters for MSRA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MSRA on UCSC Golden Path with GeneCards custom track

Genomic Location for MSRA Gene

Chromosome:
8
Start:
10,054,224 bp from pter
End:
10,428,891 bp from pter
Size:
374,668 bases
Orientation:
Plus strand

Genomic View for MSRA Gene

Genes around MSRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSRA Gene

Proteins for MSRA Gene

  • Protein details for MSRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ68-MSRA_HUMAN
    Recommended name:
    Mitochondrial peptide methionine sulfoxide reductase
    Protein Accession:
    Q9UJ68
    Secondary Accessions:
    • E9PAS8
    • Q52TC4
    • Q549N4
    • Q66MI7

    Protein attributes for MSRA Gene

    Size:
    235 amino acids
    Molecular mass:
    26132 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSRA Gene

Proteomics data for MSRA Gene at MOPED

Post-translational modifications for MSRA Gene

  • Ubiquitination at Lys 181
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for MSRA Gene

Protein Domains for MSRA Gene

Suggested Antigen Peptide Sequences for MSRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJ68

UniProtKB/Swiss-Prot:

MSRA_HUMAN :
  • Belongs to the MsrA Met sulfoxide reductase family.
Family:
  • Belongs to the MsrA Met sulfoxide reductase family.
genes like me logo Genes that share domains with MSRA: view

No data available for Gene Families for MSRA Gene

Function for MSRA Gene

Molecular function for MSRA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
UniProtKB/Swiss-Prot CatalyticActivity:
L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
UniProtKB/Swiss-Prot Function:
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Enzyme Numbers (IUBMB) for MSRA Gene

genes like me logo Genes that share phenotypes with MSRA: view

Animal Models for MSRA Gene

MGI Knock Outs for MSRA:

Animal Model Products

  • Taconic Biosciences Mouse Models for MSRA

miRNA for MSRA Gene

miRTarBase miRNAs that target MSRA

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSRA Gene

Localization for MSRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSRA Gene

Isoform 1: Mitochondrion.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.
Isoform 5: Cytoplasm. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSRA Gene COMPARTMENTS Subcellular localization image for MSRA gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
chloroplast 1

Gene Ontology (GO) - Cellular Components for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MSRA: view

Pathways & Interactions for MSRA Gene

genes like me logo Genes that share pathways with MSRA: view

Pathways by source for MSRA Gene

2 Reactome pathways for MSRA Gene

Gene Ontology (GO) - Biological Process for MSRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10452521
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with MSRA: view

No data available for SIGNOR curated interactions for MSRA Gene

Drugs & Compounds for MSRA Gene

(10) Drugs for MSRA Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Methionine Approved Nutra Enzyme, substrate 0
methionine sulfoxide Experimental Pharma 0
1,4-Dithiothreitol Experimental Pharma Target 0

(8) Additional Compounds for MSRA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MSRA: view

Transcripts for MSRA Gene

Unigene Clusters for MSRA Gene

Methionine sulfoxide reductase A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSRA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6:

Relevant External Links for MSRA Gene

GeneLoc Exon Structure for
MSRA
ECgene alternative splicing isoforms for
MSRA

Expression for MSRA Gene

mRNA expression in normal human tissues for MSRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSRA Gene

This gene is overexpressed in Kidney - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for MSRA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3), Liver, secretome (8.5), and Kidney (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSRA Gene



SOURCE GeneReport for Unigene cluster for MSRA Gene Hs.490981

mRNA Expression by UniProt/SwissProt for MSRA Gene

Q9UJ68-MSRA_HUMAN
Tissue specificity: Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus.
genes like me logo Genes that share expression patterns with MSRA: view

Protein tissue co-expression partners for MSRA Gene

Primer Products

In Situ Assay Products

Orthologs for MSRA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSRA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSRA 35
  • 87.84 (n)
  • 88.84 (a)
MSRA 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC608103 35
  • 88.41 (n)
  • 87.55 (a)
MSRA 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msra 35
  • 82.55 (n)
  • 86.27 (a)
Msra 16
Msra 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MSRA 35
  • 99.43 (n)
  • 98.72 (a)
MSRA 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msra 35
  • 81.97 (n)
  • 85.84 (a)
oppossum
(Monodelphis domestica)
Mammalia MSRA 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSRA 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSRA 35
  • 74.78 (n)
  • 79.13 (a)
MSRA 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSRA 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msra.1 35
  • 65.52 (n)
  • 61.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia msra-prov 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-221h15.1 35
  • 65.77 (n)
  • 69.37 (a)
MSRA 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip71CD 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea msra-1 36
  • 27 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR239W 35
  • 48.48 (n)
  • 38.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MXR1 36
  • 30 (a)
OneToOne
MXR1 38
rice
(Oryza sativa)
Liliopsida Os04g0482000 35
  • 54.5 (n)
  • 50.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6485 36
  • 58 (a)
OneToOne
Species with no ortholog for MSRA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSRA Gene

ENSEMBL:
Gene Tree for MSRA (if available)
TreeFam:
Gene Tree for MSRA (if available)

Paralogs for MSRA Gene

No data available for Paralogs for MSRA Gene

Variants for MSRA Gene

Sequence variations from dbSNP and Humsavar for MSRA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs14879 -- 10,428,763(+) AAGGG(A/G)CTTTC utr-variant-3-prime
rs728039 -- 10,113,765(+) TGCAT(G/T)TTTTT intron-variant
rs728877 -- 10,066,392(-) GGTTT(C/T)GGAGA intron-variant
rs728878 -- 10,066,357(-) GTTAG(C/T)TGGGA intron-variant
rs610947 -- 10,061,501(-) TAATT(A/G)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSRA Gene

Variant ID Type Subtype PubMed ID
nsv890343 CNV Gain 21882294
nsv831230 CNV Gain+Loss 17160897
nsv510128 CNV Loss 20534489
nsv890344 CNV Loss 21882294
nsv831231 CNV Gain 17160897
esv2524854 CNV Insertion 19546169
esv1116859 CNV Insertion 17803354
esv2016675 CNV Deletion 18987734
esv3698 CNV Deletion 18987735
esv2736590 CNV Deletion 23290073
nsv516061 CNV Loss 19592680
nsv890345 CNV Loss 21882294
nsv890346 CNV Loss 21882294
esv2659013 CNV Deletion 23128226
esv2666839 CNV Deletion 23128226
esv268529 CNV Insertion 20981092
nsv6078 CNV Insertion 18451855
nsv890347 CNV Loss 21882294
nsv518309 CNV Loss 19592680
esv2670330 CNV Deletion 23128226
nsv527326 CNV Gain 19592680
nsv890348 CNV Loss 21882294

Variation tolerance for MSRA Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSRA Gene

HapMap Linkage Disequilibrium report
MSRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSRA Gene

Disorders for MSRA Gene

MalaCards: The human disease database

(2) MalaCards diseases for MSRA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mycobacterium abscessus
  • m. abscessus
occult macular dystrophy
  • ocmd
- elite association - COSMIC cancer census association via MalaCards
Search MSRA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MSRA

Genetic Association Database (GAD)
MSRA
Human Genome Epidemiology (HuGE) Navigator
MSRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSRA
genes like me logo Genes that share disorders with MSRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSRA Gene

Publications for MSRA Gene

  1. Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA). (PMID: 10452521) Kuschel L. … Heinemann S.H. (FEBS Lett. 1999) 2 3 4 23 67
  2. Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. (PMID: 16480945) Schallreuter K.U. … Wood J.M. (Biochem. Biophys. Res. Commun. 2006) 3 23 25 26
  3. Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage. (PMID: 19844733) Ogawa F. … Sato S. (Arch. Dermatol. Res. 2010) 3 23
  4. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. (PMID: 20421936) Scherag A. … Meyre D. (PLoS Genet. 2010) 3 23
  5. Methionine sulfoxide reductase: a novel schizophrenia candidate gene. (PMID: 18506707) Walss-Bass C. … Raventos H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23

Products for MSRA Gene

Sources for MSRA Gene

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