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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MSR1 Gene

protein-coding GIFtS: 64
GCID: GC08M016009

macrophage scavenger receptor 1

Explore 34 diseases affiliated with
MSR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Macrophage Scavenger Receptor 1¹ ²		Macrophage Scavenger Receptor Type III²
SCARA1¹ ² ³		Macrophage Scavenger Receptor Types I And II²
CD204¹ ²		PhSR1¹
Macrophage Acetylated LDL Receptor I And II² ³		PhSR2¹
Scavenger Receptor Class A Member 1² ³		Scavenger Receptor Class A, Member 1²
SR-A²		CD204 Antigen³
SRA²

External Ids:	HGNC: 7376¹	Entrez Gene: 4481²	Ensembl: ENSG00000038945⁷	OMIM: 153622⁵	UniProtKB: P21757³

Export aliases for MSR1 gene to outside databases

Previous GC identifers: GC08M015739 GC08M015926 GC08M015975 GC08M014509

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MSR1:

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated

by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane

glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes

including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional

receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does

not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and

2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it

unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when

co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor

activity in macrophages. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MSRE_HUMAN, P21757

Function: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during

atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of

macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL

Gene Wiki entry for MSR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MSR1 gene promoter:
AP-1 ATF-2 c-Jun GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MSR1 promoter sequence

Search SABiosciences Chromatin IP Primers for MSR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22

MSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSR1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M016009: view genomic region (about GC identifiers)

Start:	15,965,387 bp from pter	End:	16,424,999 bp from pter
Size:	459,613 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MSRE_HUMAN, P21757 (See protein sequence)

Recommended Name: Macrophage scavenger receptor types I and II

Size: 451 amino acids; 49762 Da

Subunit: Homotrimer

Subcellular location: Membrane; Single-pass type II membrane protein

Secondary accessions: D3DSP3 O60505 P21759 Q45F10

Alternative splicing: 3 isoforms: P21757-1 P21757-2 P21757-3 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MSR1: NX_P21757

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21757

MSR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_002436.1 NP_619729.1 NP_619730.1

ENSEMBL proteins:

ENSP00000262101 ENSP00000405453 ENSP00000347430 ENSP00000430536 ENSP00000371428

ENSP00000428865 ENSP00000427905 ENSP00000429498 ENSP00000262100 ENSP00000444414

Human Recombinant Protein Products for MSR1:

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	Novus Biologicals MSR1 Proteins Novus Biologicals MSR1 Lysates
	Sino Biological Recombinant Protein for MSR1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MSR1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005581	collagen	IEA	--
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	--	--
GO:0005887	integral to plasma membrane	TAS	8093617
GO:0016020	membrane	--	--

MSR1 for ontologies About GeneDecksing

MSR1 Antibody Products:

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	ThermoFisher Antibodies for MSR1

Assay Products for MSR1:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MSR1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MSR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MSR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001190 Srcr_rcpt

IPR003543 Macro_scav_rcpt

IPR017448 Srcr_rcpt-rel

IPR008160 Collagen

Graphical View of Domain Structure for InterPro Entry P21757

ProtoNet protein and cluster: P21757

4 Blocks protein families:

IPB001190 Speract/scavenger receptor

IPB003543 Macrophage scavenger receptor signature

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: MSRE_HUMAN, P21757

Similarity: Contains 1 collagen-like domain

Similarity: Contains 1 SRCR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MSRE_HUMAN, P21757

Function: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during

atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of

macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL

Genatlas biochemistry entry for MSR1:

macrophage scavenger receptor 1 (oxidized low density lipoprotein receptor)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005044	scavenger receptor activity	IEA	--
GO:0005515	protein binding	IPI	17237231
GO:0030169	low-density lipoprotein particle binding	ISS	12376530

MSR1 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Msr1):

cardiovascular system	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
nervous system	other

MSR1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Msr1^tm1Csk for MSR1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MSR1

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MSR1 Browse MicroRNA Expression Plasmids
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		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate MSR1 (see all 34):
		hsa-miR-579 hsa-let-7d hsa-miR-765 hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-433 hsa-miR-203

		SwitchGear 3'UTR luciferase reporter plasmid: MSR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSR1 (see all 4) OriGene shRNA RFP: MSR1 OriGene siRNA: MSR1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MSR1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MSR1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSR1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSR1 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MSR1 (NM_002445)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MSR1
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		Sirion Biotech Customized stable knockdown cell line services for MSR1 Sirion Biotech Customized inducible knockdown cell line services for MSR1 Sirion Biotech Customized stable overexpressing cell line services for MSR1 Sirion Biotech Customized inducible overexpressing cell line services for MSR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSR1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Selected targets of C/EBPbeta

Selected targets of C/EBPbeta

1.00

Selected targets of CREB1

Selected targets of CREB1

1.00

AGE/RAGE pathway

AGE/RAGE pathway

1.00

Phagocytosis of Microbes

Phagocytosis of Microbes

1.00

LDL Oxidation in Atherogenesis

LDL Oxidation in Atherogenesis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MSR1

	Selected targets of C/EBPbeta
	Selected targets of CREB1

1 R&D Systems Pathway for MSR1

A-beta Uptake & Degradation

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MSR1

	LDL Oxidation in Atherogenesis
	Phagocytosis of Microbes

1 BioSystems Pathway for MSR1

AGE/RAGE pathway

1 Kegg Pathway (Kegg details for MSR1):

Phagosome

MSR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MSR1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/8 Interacting proteins for MSR1 (P21757^{1, 3} ENSP00000262101⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HOOK3	Q86VS8¹^,³, ENSP00000305699⁴	EBI-1776976,EBI-1777078 I2D: score=2 STRING: ENSP00000305699
HSPA1A	P08107³, ENSP00000364802⁴	I2D: score=2 STRING: ENSP00000364802
HSPA1B	P08107³	I2D: score=2
TRAF6	Q9Y4K3³	I2D: score=3
MERTK	Q12866³	I2D: score=1

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006898	receptor-mediated endocytosis	TAS	2251254
GO:0010744	positive regulation of macrophage derived foam cell differentiation	ISS	12376530
GO:0010886	positive regulation of cholesterol storage	ISS	--
GO:0030301	cholesterol transport	ISS	12376530
GO:0034381	plasma lipoprotein particle clearance	ISS	12376530

MSR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MSR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MSR1
10/18 Novoseek chemical compound relationships for MSR1 gene (see all 18) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fucoidan	73	12	19351958 (2), 15330174 (2), 12488451 (2), 20067767 (1) (see all 7)
cholesterol ester	65	6	19644050 (2), 19699207 (1), 16172428 (1), 12488451 (1)
inosine monophosphate	54.9	3	10998066 (1), 12473645 (1)
cholesterol	44.1	26	15951431 (2), 11116059 (2), 10706585 (2), 14661091 (1) (see all 11)
alpha tocopherol	34.3	5	10381284 (2), 11290823 (1), 12559471 (1), 12023009 (1)
lipid	27.5	14	11116059 (2), 19049904 (2), 12379907 (1), 16186421 (1) (see all 7)
12-o-tetradecanoylphorbol 13-acetate	22.1	1	18806314 (1)
vitamin-e	5.22	1	12559471 (1)
mannose	4.13	1	15330174 (1)
oxygen	0	7	9743233 (2), 11238031 (1), 12379907 (1), 15556945 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about MSR1 / MSRE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MSR1 gene (3 alternative transcripts):

NM_002445.3 NM_138715.2 NM_138716.2

Unigene Cluster for MSR1:

Macrophage scavenger receptor 1

Hs.147635 [show with all ESTs]

Unigene Representative Sequence: NM_138715

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262101 ENST00000445506 ENST00000355282 ENST00000522672 ENST00000381998(uc003wxb.3 uc011kxz.2)

ENST00000519060 ENST00000518960 ENST00000518026 ENST00000521876 ENST00000518343

ENST00000517522 ENST00000520846 ENST00000522130 ENST00000350896(uc010lsu.3 uc003wwz.3 uc003wxa.3)

ENST00000536385

miRNA Products:		OriGene 3'-UTR Clone (see all 3): MSR1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSR1
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate MSR1 (see all 34):
		hsa-miR-579 hsa-let-7d hsa-miR-765 hsa-let-7g hsa-let-7a hsa-miR-98 hsa-miR-433 hsa-miR-203

		SwitchGear 3'UTR luciferase reporter plasmid: MSR1 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSR1 (see all 4) OriGene shRNA RFP: MSR1 OriGene siRNA: MSR1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSR1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MSR1

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		GenScript: all cDNA clones in your preferred vector (see all 3): MSR1 (NM_002445)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSR1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSR1

Additional cDNA sequence:

AF037351.1 AK293217.1 AK293409.1 BC063878.1 D13264.1 D13265.1 D90187.1 D90188.1

8 DOTS entries:

DT.311809 DT.311810 DT.97788471 DT.100813452 DT.95362130 DT.75101110 DT.86846121 DT.95362129

24/49 AceView cDNA sequences (see all 49):

AI342012 AA569336 D90188 AF037351 NM_138716 AA489759 BF850824 AA305746

CD365565 AA933064 NM_138715 D90187 NM_002445 BQ011224 AV733201 T63943

CD367626 CB990950 BG483897 AI734941 AI299239 BG314850 CD369066 CA748515

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MSR1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b
SP1:																							-
SP2:
SP3:																							-		-
SP4:

ECgene alternative splicing isoforms for MSR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MSR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAACACCTA

About this image
See MSR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MSR1

SOURCE GeneReport for Unigene cluster: Hs.147635

UniProtKB/Swiss-Prot: MSRE_HUMAN, P21757

Tissue specificity: Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages

SABiosciences Expression via Pathway-Focused PCR Array including MSR1:

Atherosclerosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSR1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MSR1
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for MSR1 (if available)
TreeFam Gene Tree for MSR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MSR1 gene

MARCO² SCARA5²

13 SIMAP similar genes for MSR1 using alignment to 7 protein entries: MSRE_HUMAN (see all proteins):

COL1A1 COL4A6 SCARA5 COL6A6 COL13A1 COLEC11

COL21A1 COL4A3 COL17A1 COL4A1 COL6A5 COL14A1

COL7A1

MSR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72552387^1,2	C,F	pathogenic	25762996(-)	`CAATAG/TMTGAA`	6	D Y	mis¹		7		MN CSA NA	4954
rs41341748^1,2	C,F	pathogenic	25776474(+)	`TNCTCA/C/GTGGAC`	9	R G *	mis¹ stg¹		5		NA EU	5908
rs75695113^1,2		--	14509591(+)	`CTCCCA/TACCTC`	2	--	ds500¹		1		WA	118
rs34941642^1,2	F	--	14509595(-)	`GCAGA-/CGGTTG`	2	--	ds500¹		5		NS	178
rs77886166^1,2	C	--	14509714(+)	`AGTTT-/GWATTT`	2	--	ds500¹		0	--	--	--	--
rs76214069^1,2	C	--	14509715(+)	`GTTTTA/G/TATTTG`	2	--	ds500¹		1		CSA	1
rs112998571^1,2		--	14509740(+)	`ATTTAG/CGTGGA`	2	--	ds500¹		1		CSA	2
rs55811356^1,2	C	--	14510430(+)	`CCCATG/TCATAC`	2	--	ut3¹		0	--	--	--	--
rs35170613^1,2	C,F	--	14510520(+)	`GACATC/ACCAAA`	2	--	ut3¹		3		NA	6
rs6985143^1,2	C,F,H	--	14510621(+)	`ATTAAC/ATAGCT`	2	--	ut3¹		10		NS EA WA	702

HapMap Linkage Disequilibrium report for MSR1 (15965387 - 16215387 bp, first 250kb of MSR1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for MSR1
8 CNVs: 34595 30276 53815 9087 34640 52453 34641 43301
Human Gene Mutation Database (HGMD): MSR1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MSR1 for disorders           About GeneDecksing

OMIM gene information: 153622
OMIM disorders: 176807
UniProtKB/Swiss-Prot: MSRE_HUMAN, P21757

Defects in MSR1 may be a cause of prostate cancer (PC) [MIM:176807]. A malignancy originating in tissues of

the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare

histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma,

mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell

carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=MSR1

variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with

prostate cancer and co-segregate with the disease in some families

Defects in MSR1 may be a cause of Barrett esophagus (BE) [MIM:614266]. A condition characterized by a

metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type

epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of

Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the

esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is

believed to trigger the pathologic changes. Note=Genetic variants in MSR1 have been found in individuals with Barrett

esophagus and are thought to contribute to disease susceptibility

20/34 diseases for MSR1 (see all 34): About MalaCards

alzheimer's disease necrobiotic xanthogranuloma atherosclerosis xanthomatosis

barrett's esophagus coronary heart disease prostate cancer transitional cell carcinoma

basal cell carcinoma chronic myeloid leukemia myeloid leukemia prostatitis

neuroendocrine carcinoma prostate cancer, progression of hepatitis c ovarian cancer

carcinoma prostate carcinoma lung cancer rabies

1 disease from the University of Copenhagen DISEASES database for MSR1:

Prostate cancer

10/17 Novoseek disease relationships for MSR1 gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis	64.8	24	19715475 (5), 10937358 (4), 11677771 (2), 15548472 (1) (see all 13)
prostate cancer	61.4	102	20086112 (8), 15042613 (5), 18398045 (5), 17768178 (5) (see all 32)
xanthomatosis	55.6	2	11348881 (1)
prostatic intraepithelial neoplasia	49.4	1	15026346 (1)
prostate carcinoma	36.8	1	16114055 (1)
germ-line mutation	31.1	4	12839931 (3)
inflammation	26.3	7	18067591 (1), 18566991 (1), 18398045 (1), 19911804 (1) (see all 5)
somatic mutations	21	1	14695991 (1)
necrosis	16.6	7	17167049 (1), 20410100 (1), 17709607 (1), 18067591 (1) (see all 6)
alzheimers disease	9.1	3	9548586 (1), 12379907 (1), 19911804 (1)

Genetic Association Database (GAD): MSR1
Human Genome Epidemiology (HuGE) Navigator: MSR1 (37 documents)

Export disorders for MSR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MSR1 gene, integrated from 9 sources (see all 207):
(articles sorted by number of sources associating them with MSR1)

Utopia: connect your pdf to the dynamic
world of online information

Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. (PubMed id 12244320)^{1, 2, 4, 9} Xu J....Meyers D.A. (2002)
Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. (PubMed id 2251254)^{1, 2, 3} Matsumoto A....Kodama T. (1990)
Germ-line alterations in MSR1 gene and prostate cancer risk. (PubMed id 14614006)^{1, 4, 9} Seppala E.H....Schleutker J. (2003)
Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer. (PubMed id 15042613)^{1, 4, 9} Lindmark F....Gronberg H. (2004)
Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. (PubMed id 12471593)^{1, 4, 9} Xu J....Isaacs W.B. (2003)
Germline mutations of the MSR1 gene in prostate cancer families from Germany. (PubMed id 16287155)^{1, 4, 9} Maier C....Vogel W. (2006)
Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. (PubMed id 12839931)^{1, 4, 9} Miller D.C....Cooney K.A. (2003)
No association of germline alteration of MSR1 with prostate cancer risk. (PubMed id 12958598)^{1, 4, 9} Wang L....Thibodeau S.N. (2003)
Association of susceptibility alleles in ELAC2/HPC2, RNASEL/HPC1, and MSR1 with prostate cancer severity in European American and African American men. (PubMed id 15824169)^{1, 4, 9} Rennert H....Rebbeck T.R. (2005)
A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake. (PubMed id 9548586)^{1, 2, 9} Gough P.J.... Gordon S. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4481	HGNC: 7376	AceView: MSR1	Ensembl:ENSG00000038945	euGenes: HUgn4481
ECgene: MSR1	Kegg: 4481	H-InvDB: MSR1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MSR1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MSR1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/msr1/

Intellectual Property for MSR1 gene
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Patent Information for MSR1 gene:
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GeneCards and IP:
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About This Section

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macrophage scavenger receptor 1

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MSR1 Gene

macrophage scavenger receptor 1

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