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Aliases for MSR1 Gene

Aliases for MSR1 Gene

  • Macrophage Scavenger Receptor 1 2 3 5
  • Macrophage Acetylated LDL Receptor I And II 3 4
  • Scavenger Receptor Class A Member 1 3 4
  • SCARA1 3 4
  • Macrophage Scavenger Receptor Type III 3
  • Scavenger Receptor Class A, Member 1 3
  • CD204 Antigen 4
  • CD204 3
  • PhSR1 3
  • PhSR2 3
  • SR-A 3
  • SRA 3

External Ids for MSR1 Gene

Previous GeneCards Identifiers for MSR1 Gene

  • GC08M015739
  • GC08M015926
  • GC08M015975
  • GC08M014509

Summaries for MSR1 Gene

Entrez Gene Summary for MSR1 Gene

  • This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSR1 Gene

MSR1 (Macrophage Scavenger Receptor 1) is a Protein Coding gene. Diseases associated with MSR1 include Prostate Cancer and Barrett Esophagus/Esophageal Adenocarcinoma. Among its related pathways are A-beta Pathways: Uptake and Degradation and Phagosome. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and scavenger receptor activity. An important paralog of this gene is LOXL1.

UniProtKB/Swiss-Prot for MSR1 Gene

  • Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.

Gene Wiki entry for MSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSR1 Gene

Genomics for MSR1 Gene

Regulatory Elements for MSR1 Gene

Enhancers for MSR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MSR1 on UCSC Golden Path with GeneCards custom track

Promoters for MSR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MSR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MSR1 Gene

Chromosome:
8
Start:
16,107,878 bp from pter
End:
16,567,490 bp from pter
Size:
459,613 bases
Orientation:
Minus strand

Genomic View for MSR1 Gene

Genes around MSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSR1 Gene

Proteins for MSR1 Gene

  • Protein details for MSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21757-MSRE_HUMAN
    Recommended name:
    Macrophage scavenger receptor types I and II
    Protein Accession:
    P21757
    Secondary Accessions:
    • D3DSP3
    • O60505
    • P21759
    • Q45F10

    Protein attributes for MSR1 Gene

    Size:
    451 amino acids
    Molecular mass:
    49762 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for MSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSR1 Gene

Proteomics data for MSR1 Gene at MOPED

Post-translational modifications for MSR1 Gene

  • Glycosylation at Asn 82, Asn 102, Asn 143, Asn 184, Asn 221, Asn 249, and Asn 267
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MSR1 Gene

Domains & Families for MSR1 Gene

Gene Families for MSR1 Gene

Suggested Antigen Peptide Sequences for MSR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21757

UniProtKB/Swiss-Prot:

MSRE_HUMAN :
  • Contains 1 collagen-like domain.
Domain:
  • Contains 1 collagen-like domain.
  • Contains 1 SRCR domain.
genes like me logo Genes that share domains with MSR1: view

Function for MSR1 Gene

Molecular function for MSR1 Gene

GENATLAS Biochemistry:
macrophage scavenger receptor 1 (oxidized low density lipoprotein receptor)
UniProtKB/Swiss-Prot Function:
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
genes like me logo Genes that share phenotypes with MSR1: view

Human Phenotype Ontology for MSR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MSR1 Gene

MGI Knock Outs for MSR1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for MSR1 Gene

Localization for MSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSR1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSR1 Gene COMPARTMENTS Subcellular localization image for MSR1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005829 cytosol IEA --
GO:0005887 integral component of plasma membrane TAS 8093617
GO:0016021 integral component of membrane IEA --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with MSR1: view

Pathways & Interactions for MSR1 Gene

genes like me logo Genes that share pathways with MSR1: view

Pathways by source for MSR1 Gene

1 BioSystems pathway for MSR1 Gene
1 KEGG pathway for MSR1 Gene
1 R&D Systems pathway for MSR1 Gene

SIGNOR curated interactions for MSR1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA,TAS --
GO:0010744 positive regulation of macrophage derived foam cell differentiation ISS 12376530
GO:0071407 cellular response to organic cyclic compound IEA --
genes like me logo Genes that share ontologies with MSR1: view

Drugs & Compounds for MSR1 Gene

(7) Drugs for MSR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for MSR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSR1: view

Transcripts for MSR1 Gene

Unigene Clusters for MSR1 Gene

Macrophage scavenger receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for MSR1 Gene

GeneLoc Exon Structure for
MSR1
ECgene alternative splicing isoforms for
MSR1

Expression for MSR1 Gene

mRNA expression in normal human tissues for MSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSR1 Gene

This gene is overexpressed in Lung (x7.1).

Protein differential expression in normal tissues from HIPED for MSR1 Gene

This gene is overexpressed in Pancreas (48.3) and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MSR1 Gene



SOURCE GeneReport for Unigene cluster for MSR1 Gene Hs.147635

mRNA Expression by UniProt/SwissProt for MSR1 Gene

P21757-MSRE_HUMAN
Tissue specificity: Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.
genes like me logo Genes that share expression patterns with MSR1: view

No data available for Protein tissue co-expression partners for MSR1 Gene

Orthologs for MSR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSR1 35
  • 81.07 (n)
  • 74.16 (a)
MSR1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSR1 35
  • 86.33 (n)
  • 81.37 (a)
MSR1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msr1 35
  • 78 (n)
  • 73.02 (a)
Msr1 16
Msr1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MSR1 35
  • 99.31 (n)
  • 99.31 (a)
MSR1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msr1 35
  • 77.58 (n)
  • 70.91 (a)
oppossum
(Monodelphis domestica)
Mammalia MSR1 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSR1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msr1 35
  • 53.95 (n)
  • 42.54 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01112729.1 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for MSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSR1 Gene

ENSEMBL:
Gene Tree for MSR1 (if available)
TreeFam:
Gene Tree for MSR1 (if available)

Paralogs for MSR1 Gene

Paralogs for MSR1 Gene

genes like me logo Genes that share paralogs with MSR1: view

Variants for MSR1 Gene

Sequence variations from dbSNP and Humsavar for MSR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs35175081 - 16,177,921(-) GAAAT(C/G/T)TGATG reference, missense
VAR_025191 -
rs13306543 - 16,164,076(-) TATCA(C/T)TTTAA reference, missense
VAR_066581 -
rs145597376 - 16,175,282(+) GAAGG(G/T)AAGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MSR1 Gene

Variant ID Type Subtype PubMed ID
nsv890530 CNV Gain 21882294
nsv831241 CNV Gain+Loss 17160897
dgv249e55 CNV Loss 17911159
dgv7733n71 CNV Loss 21882294
esv2668117 CNV Deletion 23128226
nsv470195 CNV Loss 18288195
dgv877n27 CNV Loss 19166990
nsv516531 CNV Loss 19592680
nsv465581 CNV Loss 19166990
esv269479 CNV Insertion 20981092
dgv7734n71 CNV Loss 21882294
nsv465582 CNV Loss 19166990
esv3448 CNV Deletion 18987735
esv2736661 CNV Deletion 23290073
esv2736663 CNV Deletion 23290073
nsv824552 CNV Loss 20364138
nsv519153 CNV Loss 19592680
nsv520688 CNV Loss 19592680
nsv512943 CNV Insertion 21212237
esv2736664 CNV Deletion 23290073
nsv890536 CNV Gain 21882294

Variation tolerance for MSR1 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.97; 89.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSR1 Gene

Human Gene Mutation Database (HGMD)
MSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSR1 Gene

Disorders for MSR1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MSR1 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
barrett esophagus/esophageal adenocarcinoma
  • esophageal cancer
necrobiotic xanthogranuloma
  • nxg
atherosclerosis
  • arteriosclerosis
pontocerebellar hypoplasia, type 6
  • pontocerebellar hypoplasia type 6
- elite association - COSMIC cancer census association via MalaCards
Search MSR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MSRE_HUMAN
  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269 PubMed:21791690}. Note=The disease may be caused by mutations affecting the gene represented in this entry. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility.
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:12244320}. Note=The disease may be caused by mutations affecting the gene represented in this entry. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families.

Relevant External Links for MSR1

Genetic Association Database (GAD)
MSR1
Human Genome Epidemiology (HuGE) Navigator
MSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSR1
genes like me logo Genes that share disorders with MSR1: view

No data available for Genatlas for MSR1 Gene

Publications for MSR1 Gene

  1. Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. (PMID: 12244320) Xu J. … Meyers D.A. (Nat. Genet. 2002) 3 4 23 48 67
  2. COPD is associated with a macrophage scavenger receptor-1 gene sequence variation. (PMID: 20081102) Ohar J.A. … Holian A. (Chest 2010) 3 23
  3. Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. (PMID: 20086112) Beuten J. … Leach R.J. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 23
  4. CD36 and macrophage scavenger receptor a modulate foam cell formation via inhibition of lipid-laden platelet phagocytosis. (PMID: 20414830) Seizer P. … May A.E. (Semin. Thromb. Hemost. 2010) 3 23
  5. Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages. (PMID: 18922854) Liao D. … Chen C. (Blood 2009) 3 23

Products for MSR1 Gene

Sources for MSR1 Gene

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