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Aliases for MSN Gene

Aliases for MSN Gene

  • Moesin 2 3 3 5
  • Membrane-Organizing Extension Spike Protein 3 4
  • Epididymis Luminal Protein 70 3
  • HEL70 3
  • IMD50 3

External Ids for MSN Gene

Previous GeneCards Identifiers for MSN Gene

  • GC0XP061107
  • GC0XP062352
  • GC0XP063120
  • GC0XP063754
  • GC0XP064670
  • GC0XP064804
  • GC0XP064887
  • GC0XP058715

Summaries for MSN Gene

Entrez Gene Summary for MSN Gene

  • Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSN Gene

MSN (Moesin) is a Protein Coding gene. Diseases associated with MSN include Immunodeficiency 50 and Neurofibromatosis, Type Ii. Among its related pathways are RhoA signaling pathway and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include protein kinase binding and actin binding. An important paralog of this gene is RDX.

UniProtKB/Swiss-Prot for MSN Gene

  • Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666).

Gene Wiki entry for MSN Gene

Additional gene information for MSN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSN Gene

Genomics for MSN Gene

GeneHancer (GH) Regulatory Elements for MSN Gene

Promoters and enhancers for MSN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI065666 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.5 +81.1 81112 5.4 HDGF SIN3A POLR2B ZNF592 GMEB1 SMARCA4 NBN CTCF KLF1 BACH1 MSN GC0XM065725 GC0XM065726 GC0XM065596 GC0XM065545
GH0XI065587 Enhancer 0.7 Ensembl ENCODE 550.8 +0.1 66 2.4 CTBP1 NFIC POLR2A VEZF1 CBFA2T3 GABPA ZNF592 MSN LAS1L GC0XM065596 GC0XM065545
GH0XI065693 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +109.6 109592 8 HDGF HDAC1 PKNOX1 BMI1 IRF4 ZBTB40 TCF12 ATF7 ETV6 BCLAF1 MSN MIR223 GC0XM065725 GC0XM065726 GC0XM065596 GC0XM065545
GH0XI066006 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 9.3 +426.8 426777 16.4 PKNOX1 SMAD1 ARNT POLR2B ZNF766 CBX5 E2F8 JUNB REST ZNF592 ENSG00000274536 GC0XP066014 VSIG4 MSN HEPH MIR223 GC0XM065963 GC0XM065545
GH0XI065996 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +411.7 411661 8.1 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 POLR2B ZNF766 GATA2 ATF7 ENSG00000237311 MSN HEPH GC0XP066014 GC0XM065963 GC0XM065545
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MSN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MSN gene promoter:

Genomic Locations for MSN Gene

Genomic Locations for MSN Gene
153,555 bases
Plus strand

Genomic View for MSN Gene

Genes around MSN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSN Gene

Proteins for MSN Gene

  • Protein details for MSN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for MSN Gene

    577 amino acids
    Molecular mass:
    67820 Da
    Quaternary structure:
    • In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1. Interacts with PPP1R16B. Interacts with PDZD8. Interacts with SELPLG and SYK; mediates the activation of SYK by SELPLG. Interacts with PDPN (via cytoplasmic domain); activates RHOA and promotes epithelial-mesenchymal transition (PubMed:17046996).

    Three dimensional structures from OCA and Proteopedia for MSN Gene

neXtProt entry for MSN Gene

Post-translational modifications for MSN Gene

  • Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization.
  • S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Ubiquitination at isoforms=79, isoforms=139, Lys209, isoforms=352, isoforms=448, and isoforms=523

Other Protein References for MSN Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MSN (Moesin)
  • Abcam antibodies for MSN

No data available for DME Specific Peptides for MSN Gene

Domains & Families for MSN Gene

Gene Families for MSN Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MSN Gene

Graphical View of Domain Structure for InterPro Entry



  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
genes like me logo Genes that share domains with MSN: view

Function for MSN Gene

Molecular function for MSN Gene

GENATLAS Biochemistry:
moesin,filopodial protein involved in cell recognition,cell movement and morphological changes,membrane-organizing extension spike protein,ezrin/moesin/radixin-like moesin (ERM) family member responding and participating in reorganization of membrane-cytoplasmic interactions,and in regulation of linkage of the cytoskeleton to the plasma membrane,interacting with the cytoplasmic region of ICAM3 and redistributed to the uropod of T lymphocytes during cell polarization
UniProtKB/Swiss-Prot EnzymeRegulation:
A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
UniProtKB/Swiss-Prot Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666).

Gene Ontology (GO) - Molecular Function for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003779 actin binding IEA --
GO:0005102 receptor binding IPI 15819698
GO:0005200 structural constituent of cytoskeleton TAS 1924289
GO:0005515 protein binding IPI 7844168
genes like me logo Genes that share ontologies with MSN: view
genes like me logo Genes that share phenotypes with MSN: view

Human Phenotype Ontology for MSN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MSN Gene

MGI Knock Outs for MSN:

miRNA for MSN Gene

miRTarBase miRNAs that target MSN

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for MSN Gene

Localization for MSN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSN Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment. {ECO:0000250, ECO:0000269 PubMed:18586956}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSN gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
endosome 2
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IEA --
GO:0005615 extracellular space IDA,HDA 16502470
GO:0005634 nucleus IDA,HDA 16791210
GO:0005737 cytoplasm IEA,HDA 16791210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MSN: view

Pathways & Interactions for MSN Gene

genes like me logo Genes that share pathways with MSN: view

SIGNOR curated interactions for MSN Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001771 immunological synapse formation IDA 27405666
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0007010 cytoskeleton organization IEA --
GO:0007159 leukocyte cell-cell adhesion IEP 12082081
GO:0008360 regulation of cell shape IMP 24862762
genes like me logo Genes that share ontologies with MSN: view

Drugs & Compounds for MSN Gene

(11) Drugs for MSN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for MSN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSN: view

Transcripts for MSN Gene

Unigene Clusters for MSN Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for MSN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MSN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSN Gene

mRNA differential expression in normal tissues according to GTEx for MSN Gene

This gene is overexpressed in Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for MSN Gene

This gene is overexpressed in Lymph node (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSN Gene

Protein tissue co-expression partners for MSN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MSN Gene:


SOURCE GeneReport for Unigene cluster for MSN Gene:


mRNA Expression by UniProt/SwissProt for MSN Gene:

Tissue specificity: In all tissues and cultured cells studied.

Evidence on tissue expression from TISSUES for MSN Gene

  • Blood(4.8)
  • Liver(4.6)
  • Pancreas(4.4)
  • Nervous system(4.3)
  • Skin(4.2)
  • Lung(3.7)
  • Heart(3.3)
  • Kidney(3.2)
  • Intestine(3)
  • Eye(2.7)
  • Lymph node(2.7)
  • Adrenal gland(2.5)
  • Muscle(2.5)
  • Spleen(2.5)
  • Thyroid gland(2.4)
  • Bone marrow(2)
  • Gall bladder(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with MSN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSN Gene

Orthologs for MSN Gene

This gene was present in the common ancestor of animals.

Orthologs for MSN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MSN 33 34
  • 93.01 (n)
(Canis familiaris)
Mammalia MSN 33 34
  • 92.37 (n)
(Mus musculus)
Mammalia Msn 33 16 34
  • 92.09 (n)
(Rattus norvegicus)
Mammalia Msn 33
  • 91.68 (n)
(Ornithorhynchus anatinus)
Mammalia MSN 34
  • 83 (a)
(Monodelphis domestica)
Mammalia MSN 34
  • 76 (a)
(Gallus gallus)
Aves MSN 34
  • 94 (a)
(Anolis carolinensis)
Reptilia MSN 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia msn 33
  • 79.26 (n)
(Danio rerio)
Actinopterygii msna 34
  • 84 (a)
msnb 34
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta MOEH_ANOGA 33
  • 65.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta Moe 35 33 34
  • 65 (n)
Mer 35
  • 40 (a)
(Caenorhabditis elegans)
Secernentea erm-1 35 33 34
  • 59.14 (n)
nfm-1 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6897 34
  • 55 (a)
Species where no ortholog for MSN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSN Gene

Gene Tree for MSN (if available)
Gene Tree for MSN (if available)

Paralogs for MSN Gene

Paralogs for MSN Gene

(15) SIMAP similar genes for MSN Gene using alignment to 3 proteins: Pseudogenes for MSN Gene

genes like me logo Genes that share paralogs with MSN: view

Variants for MSN Gene

Sequence variations from dbSNP and Humsavar for MSN Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1057519074 pathogenic, Immunodeficiency 50, 50 (IMD50) [MIM:300988] 65,731,150(+) C/T coding_sequence_variant, missense_variant
rs1057519075 pathogenic, Immunodeficiency 50 65,739,816(+) C/T coding_sequence_variant, stop_gained
rs1000017058 -- 65,654,420(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000018452 -- 65,590,074(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000026245 -- 65,648,638(+) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MSN Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv3558926 CNV deletion 23714750
esv3574012 CNV loss 25503493

Variation tolerance for MSN Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSN Gene

Disorders for MSN Gene

MalaCards: The human disease database

(8) MalaCards diseases for MSN Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MSN in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency 50 (IMD50) [MIM:300988]: A primary immunodeficiency disorder characterized by onset of recurrent bacterial or varicella zoster virus infections in early childhood, profound lymphopenia, hypogammaglobulinemia, fluctuating monocytopenia and neutropenia, and a poor immune response to vaccine antigens. {ECO:0000269 PubMed:27405666}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MSN

genes like me logo Genes that share disorders with MSN: view

No data available for Genatlas for MSN Gene

Publications for MSN Gene

  1. Moesin: a member of the protein 4.1-talin-ezrin family of proteins. (PMID: 1924289) Lankes WT … Furthmayr H (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22 58
  2. TIMAP is a positive regulator of pulmonary endothelial barrier function. (PMID: 18586956) Csortos C … Verin AD (American journal of physiology. Lung cellular and molecular physiology 2008) 3 4 22 58
  3. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PMID: 12387735) Urzainqui A … Sánchez-Madrid F (Immunity 2002) 3 4 22 58
  4. Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts. (PMID: 7628534) Amieva MR … Furthmayr H (Experimental cell research 1995) 2 3 22 58
  5. X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene. (PMID: 27405666) Lagresle-Peyrou C … André-Schmutz I (The Journal of allergy and clinical immunology 2016) 3 4 58

Products for MSN Gene

  • Addgene plasmids for MSN

Sources for MSN Gene

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