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Aliases for MSN Gene

Aliases for MSN Gene

  • Moesin 2 3 5
  • Membrane-Organizing Extension Spike Protein 3 4
  • Epididymis Luminal Protein 70 3
  • HEL70 3

External Ids for MSN Gene

Previous GeneCards Identifiers for MSN Gene

  • GC0XP061107
  • GC0XP062352
  • GC0XP063120
  • GC0XP063754
  • GC0XP064670
  • GC0XP064804
  • GC0XP064887
  • GC0XP058715

Summaries for MSN Gene

Entrez Gene Summary for MSN Gene

  • Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSN Gene

MSN (Moesin) is a Protein Coding gene. Diseases associated with MSN include verrucous carcinoma and measles. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Influenza A. GO annotations related to this gene include protein kinase binding and actin binding. An important paralog of this gene is C1orf106.

UniProtKB/Swiss-Prot for MSN Gene

  • Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.

Gene Wiki entry for MSN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSN Gene

Genomics for MSN Gene

Regulatory Elements for MSN Gene

Enhancers for MSN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MSN on UCSC Golden Path with GeneCards custom track

Genomic Location for MSN Gene

Chromosome:
X
Start:
65,588,377 bp from pter
End:
65,741,931 bp from pter
Size:
153,555 bases
Orientation:
Plus strand

Genomic View for MSN Gene

Genes around MSN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSN Gene

Proteins for MSN Gene

  • Protein details for MSN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26038-MOES_HUMAN
    Recommended name:
    Moesin
    Protein Accession:
    P26038

    Protein attributes for MSN Gene

    Size:
    577 amino acids
    Molecular mass:
    67820 Da
    Quaternary structure:
    • In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1. Interacts with PPP1R16B. Interacts with PDZD8. Interacts with SELPLG and SYK; mediates the activation of SYK by SELPLG.

    Three dimensional structures from OCA and Proteopedia for MSN Gene

neXtProt entry for MSN Gene

Proteomics data for MSN Gene at MOPED

Post-translational modifications for MSN Gene

  • Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization.
  • S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Ubiquitination at Lys 79, Lys 139, Lys 209, Lys 352, Lys 448, and Lys 523
  • Modification sites at PhosphoSitePlus

Other Protein References for MSN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSN Gene

Domains & Families for MSN Gene

Suggested Antigen Peptide Sequences for MSN Gene

Graphical View of Domain Structure for InterPro Entry

P26038

UniProtKB/Swiss-Prot:

MOES_HUMAN :
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
Domain:
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with MSN: view

No data available for Gene Families for MSN Gene

Function for MSN Gene

Molecular function for MSN Gene

GENATLAS Biochemistry:
moesin,filopodial protein involved in cell recognition,cell movement and morphological changes,membrane-organizing extension spike protein,ezrin/moesin/radixin-like moesin (ERM) family member responding and participating in reorganization of membrane-cytoplasmic interactions,and in regulation of linkage of the cytoskeleton to the plasma membrane,interacting with the cytoplasmic region of ICAM3 and redistributed to the uropod of T lymphocytes during cell polarization
UniProtKB/Swiss-Prot EnzymeRegulation:
A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
UniProtKB/Swiss-Prot Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.

Gene Ontology (GO) - Molecular Function for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 15819698
genes like me logo Genes that share ontologies with MSN: view
genes like me logo Genes that share phenotypes with MSN: view

Animal Models for MSN Gene

MGI Knock Outs for MSN:

Animal Model Products

miRNA for MSN Gene

miRTarBase miRNAs that target MSN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSN Gene

Localization for MSN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSN Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment. {ECO:0000250, ECO:0000269 PubMed:18586956}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSN Gene COMPARTMENTS Subcellular localization image for MSN gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IEA --
GO:0005737 cytoplasm IEA,IDA 16791210
GO:0005902 microvillus IDA 12082081
GO:0005925 colocalizes_with focal adhesion IDA 21282464
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with MSN: view

Pathways & Interactions for MSN Gene

genes like me logo Genes that share pathways with MSN: view

SIGNOR curated interactions for MSN Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008361 NOT regulation of cell size IMP 22467863
GO:0022614 membrane to membrane docking IEP 12082081
GO:0045198 establishment of epithelial cell apical/basal polarity IMP 24862762
GO:0071394 cellular response to testosterone stimulus IDA 24065547
GO:2000643 positive regulation of early endosome to late endosome transport IGI 21148287
genes like me logo Genes that share ontologies with MSN: view

Drugs & Compounds for MSN Gene

(11) Drugs for MSN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for MSN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSN: view

Transcripts for MSN Gene

Unigene Clusters for MSN Gene

Moesin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for MSN Gene

GeneLoc Exon Structure for
MSN
ECgene alternative splicing isoforms for
MSN

Expression for MSN Gene

mRNA expression in normal human tissues for MSN Gene

mRNA differential expression in normal tissues according to GTEx for MSN Gene

This gene is overexpressed in Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for MSN Gene

This gene is overexpressed in Lymph node (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSN Gene



SOURCE GeneReport for Unigene cluster for MSN Gene Hs.87752

mRNA Expression by UniProt/SwissProt for MSN Gene

P26038-MOES_HUMAN
Tissue specificity: In all tissues and cultured cells studied.
genes like me logo Genes that share expression patterns with MSN: view

Protein tissue co-expression partners for MSN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MSN Gene

Orthologs for MSN Gene

This gene was present in the common ancestor of animals.

Orthologs for MSN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSN 35
  • 93.01 (n)
  • 98.61 (a)
MSN 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSN 35
  • 92.37 (n)
  • 98.79 (a)
MSN 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msn 35
  • 92.09 (n)
  • 98.61 (a)
Msn 16
Msn 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msn 35
  • 91.68 (n)
  • 97.75 (a)
oppossum
(Monodelphis domestica)
Mammalia MSN 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSN 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSN 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSN 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msn 35
  • 79.26 (n)
  • 88.56 (a)
zebrafish
(Danio rerio)
Actinopterygii msna 36
  • 84 (a)
OneToMany
msnb 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mer 37
  • 40 (a)
Moe 37
  • 59 (a)
Moe 35
  • 65 (n)
  • 63.57 (a)
Moe 36
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta MOEH_ANOGA 35
  • 65.18 (n)
  • 63.39 (a)
worm
(Caenorhabditis elegans)
Secernentea erm-1 37
  • 54 (a)
nfm-1 37
  • 39 (a)
erm-1 35
  • 59.14 (n)
  • 59.74 (a)
erm-1 36
  • 56 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6897 36
  • 55 (a)
OneToMany
Species with no ortholog for MSN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSN Gene

ENSEMBL:
Gene Tree for MSN (if available)
TreeFam:
Gene Tree for MSN (if available)

Paralogs for MSN Gene

Paralogs for MSN Gene

(15) SIMAP similar genes for MSN Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MSN Gene

genes like me logo Genes that share paralogs with MSN: view

Variants for MSN Gene

Sequence variations from dbSNP and Humsavar for MSN Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747684733 -- 65,623,915(+) TGTTA(C/T)AGGTA intron-variant
rs747717262 -- 65,735,307(+) CAAGC(A/G)GATCT reference, missense
rs747759325 -- 65,636,926(+) AATAC(-/A)AAAAA intron-variant
rs747761307 -- 65,646,581(+) AACAA(A/G)AACCT intron-variant
rs747764156 -- 65,650,722(+) TGTCC(C/T)GTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSN Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354

Variation tolerance for MSN Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSN Gene

HapMap Linkage Disequilibrium report
MSN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSN Gene

Disorders for MSN Gene

MalaCards: The human disease database

(5) MalaCards diseases for MSN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
verrucous carcinoma
  • verrucous carcinoma nos
measles
  • morbilli
meningioma, familial
  • meningioma
aplastic anemia
  • pulmonary fibrosis, idiopathic
progesterone-receptor positive breast cancer
- elite association - COSMIC cancer census association via MalaCards
Search MSN in MalaCards View complete list of genes associated with diseases

Relevant External Links for MSN

Genetic Association Database (GAD)
MSN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSN
genes like me logo Genes that share disorders with MSN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSN Gene

Publications for MSN Gene

  1. Moesin: a member of the protein 4.1-talin-ezrin family of proteins. (PMID: 1924289) Lankes W.T. … Furthmayr H. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23 67
  2. Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts. (PMID: 7628534) Amieva M.R. … Furthmayr H. (Exp. Cell Res. 1995) 2 3 23
  3. Knockdown of moesin expression accelerates cellular senescence of human dermal microvascular endothelial cells. (PMID: 20376899) Lee J.H. … Lee K.H. (Yonsei Med. J. 2010) 3 23
  4. Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade. (PMID: 20429915) He M. … Fu X. (BMC Cancer 2010) 3 23
  5. Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes. (PMID: 19066282) Barrero-Villar M. … Valenzuela-FernA!ndez A. (J. Cell. Sci. 2009) 3 23

Products for MSN Gene

Sources for MSN Gene

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