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Aliases for MSN Gene

Aliases for MSN Gene

  • Moesin 2 3
  • Membrane-Organizing Extension Spike Protein 3 4
  • Epididymis Luminal Protein 70 3
  • HEL70 3

External Ids for MSN Gene

Summaries for MSN Gene

Entrez Gene Summary for MSN Gene

  • Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSN Gene

MSN (Moesin) is a Protein Coding gene. Diseases associated with MSN include measles. Among its related pathways are Proteoglycans in cancer and Regulation of actin cytoskeleton. GO annotations related to this gene include protein kinase binding and structural constituent of cytoskeleton. An important paralog of this gene is C1orf106.

UniProtKB/Swiss-Prot for MSN Gene

  • Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.

Gene Wiki entry for MSN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSN Gene

Genomics for MSN Gene

Genomic Location for MSN Gene

Start:
65,588,377 bp from pter
End:
65,741,931 bp from pter
Size:
153,555 bases
Orientation:
Plus strand

Genomic View for MSN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSN Gene

Regulatory Elements for MSN Gene

Proteins for MSN Gene

  • Protein details for MSN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26038-MOES_HUMAN
    Recommended name:
    Moesin
    Protein Accession:
    P26038
    Secondary Accessions:

    Protein attributes for MSN Gene

    Size:
    577 amino acids
    Molecular mass:
    67820 Da
    Quaternary structure:
    • In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1. Interacts with PPP1R16B. Interacts with PDZD8. Interacts with SELPLG and SYK; mediates the activation of SYK by SELPLG.

    Three dimensional structures from OCA and Proteopedia for MSN Gene

neXtProt entry for MSN Gene

Proteomics data for MSN Gene at MOPED

Post-translational modifications for MSN Gene

  • Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization.
  • S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys35, Lys79, Lys83, Lys139, Lys209, Lys237, Lys296, Lys352, Lys448, and Lys523

Other Protein References for MSN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MSN Gene

Domains for MSN Gene

UniProtKB/Swiss-Prot:

MOES_HUMAN
Domain:
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.:
    • P26038
  • Contains 1 FERM domain.:
    • P26038
genes like me logo Genes that share domains with MSN: view

No data available for Gene Families for MSN Gene

Function for MSN Gene

Molecular function for MSN Gene

GENATLAS Biochemistry: moesin,filopodial protein involved in cell recognition,cell movement and morphological changes,membrane-organizing extension spike protein,ezrin/moesin/radixin-like moesin (ERM) family member responding and participating in reorganization of membrane-cytoplasmic interactions,and in regulation of linkage of the cytoskeleton to the plasma membrane,interacting with the cytoplasmic region of ICAM3 and redistributed to the uropod of T lymphocytes during cell polarization
UniProtKB/Swiss-Prot EnzymeRegulation: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.
UniProtKB/Swiss-Prot Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.

Gene Ontology (GO) - Molecular Function for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003779 actin binding IEA --
GO:0005102 receptor binding IPI 15819698
GO:0005200 structural constituent of cytoskeleton TAS 1924289
GO:0005515 protein binding IPI 10806479
genes like me logo Genes that share ontologies with MSN: view
genes like me logo Genes that share phenotypes with MSN: view

Animal Models for MSN Gene

MGI Knock Outs for MSN:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MSN Gene

Localization for MSN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSN Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment. {ECO:0000250, ECO:0000269 PubMed:18586956}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSN Gene COMPARTMENTS Subcellular localization image for MSN gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
nucleus 4
cytosol 3
endosome 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 16791210
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton TAS 16130169
genes like me logo Genes that share ontologies with MSN: view

Pathways for MSN Gene

genes like me logo Genes that share pathways with MSN: view

Pathways by source for MSN Gene

Gene Ontology (GO) - Biological Process for MSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0007159 leukocyte cell-cell adhesion IEP 12082081
GO:0010628 positive regulation of gene expression IGI 23264465
GO:0022614 membrane to membrane docking IEP 12082081
GO:0050900 leukocyte migration IEP 12082081
genes like me logo Genes that share ontologies with MSN: view

Compounds for MSN Gene

(23) Novoseek inferred chemical compound relationships for MSN Gene

Compound -log(P) Hits PubMed IDs
threonine 40.9 7
tyrosine 40.4 13
pip2 39.4 1
phosphatidylinositol 28.6 5
phosphotyrosine 26.8 3
genes like me logo Genes that share compounds with MSN: view

Transcripts for MSN Gene

Unigene Clusters for MSN Gene

Moesin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for MSN Gene

GeneLoc Exon Structure for
MSN
ECgene alternative splicing isoforms for
MSN

Expression for MSN Gene

mRNA expression in normal human tissues for MSN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSN Gene

This gene is overexpressed in Whole Blood (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSN Gene

SOURCE GeneReport for Unigene cluster for MSN Gene Hs.87752

mRNA Expression by UniProt/SwissProt for MSN Gene

P26038-MOES_HUMAN
Tissue specificity: In all tissues and cultured cells studied
genes like me logo Genes that share expressions with MSN: view

Orthologs for MSN Gene

This gene was present in the common ancestor of animals.

Orthologs for MSN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSN 36
  • 93.01 (n)
  • 98.61 (a)
MSN 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSN 36
  • 92.37 (n)
  • 98.79 (a)
MSN 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msn 36
  • 92.09 (n)
  • 98.61 (a)
Msn 16
Msn 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSN 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSN 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msn 36
  • 91.68 (n)
  • 97.75 (a)
chicken
(Gallus gallus)
Aves MSN 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSN 37
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msn 36
  • 79.26 (n)
  • 88.56 (a)
zebrafish
(Danio rerio)
Actinopterygii msna 37
  • 84 (a)
OneToMany
msnb 37
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta MOEH_ANOGA 36
  • 65.18 (n)
  • 63.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Moe 36
  • 65 (n)
  • 63.57 (a)
Moe 37
  • 54 (a)
OneToMany
Moe 38
  • 59 (a)
Mer 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea erm-1 36
  • 59.14 (n)
  • 59.74 (a)
erm-1 37
  • 56 (a)
OneToMany
nfm-1 38
  • 39 (a)
erm-1 38
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6897 37
  • 55 (a)
OneToMany
Species with no ortholog for MSN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSN Gene

ENSEMBL:
Gene Tree for MSN (if available)
TreeFam:
Gene Tree for MSN (if available)

Paralogs for MSN Gene

Paralogs for MSN Gene

Selected SIMAP similar genes for MSN Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MSN Gene

genes like me logo Genes that share paralogs with MSN: view

Variants for MSN Gene

Sequence variations from dbSNP and Humsavar for MSN Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs13138 -- 65,741,822(-) TGAAT(A/G)CAAAA utr-variant-3-prime
rs13731 -- 65,740,939(+) ATCCC(A/G)GCCTT utr-variant-3-prime
rs728421 -- 65,678,295(+) AATAT(A/G)GGGGA intron-variant
rs959215 -- 65,607,593(-) CTTCC(C/T)GAAGT intron-variant
rs959216 -- 65,607,546(-) CAAGG(A/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSN Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354

Relevant External Links for MSN Gene

HapMap Linkage Disequilibrium report
MSN
Locus Specific Mutation Databases (LSDB)
MSN

Disorders for MSN Gene

(1) MalaCards Diseases for MSN Gene

Search for MSN Gene in MalaCards »

(1) University of Copenhagen DISEASES for MSN Gene

(32) Novoseek inferred disease relationships for MSN Gene

Disease -log(P) Hits PubMed IDs
neurofibromatosis type 2 86.1 6
schwannoma 54 5
meningioma 51.5 3
tumors 38.7 33
measles 32.8 13

Relevant External Links for MSN

Genetic Association Database (GAD)
MSN
genes like me logo Genes that share disorders with MSN: view

No data available for UniProtKB/Swiss-Prot for MSN Gene

Publications for MSN Gene

  1. Moesin: a member of the protein 4.1-talin-ezrin family of proteins. (PMID: 1924289) Lankes W.T. … Furthmayr H. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts. (PMID: 7628534) Amieva M.R. … Furthmayr H. (Exp. Cell Res. 1995) 2 3 23
  3. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PMID: 12387735) Urzainqui A. … Sanchez-Madrid F. (Immunity 2002) 3 4 23
  4. The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin. (PMID: 11706008) Ivetic A. … Ager A. (J. Biol. Chem. 2002) 3 23
  5. The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain. (PMID: 11716484) Wientjes F.B. … Segal A.W. (Biochem. Biophys. Res. Commun. 2001) 3 23

Products for MSN Gene

  • Addgene plasmids for MSN

Sources for MSN Gene

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