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MSN Gene

protein-coding   GIFtS: 67
GCID: GC0XP064887

Moesin

  See MSN-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
moesin1 2
Membrane-Organizing Extension Spike Protein2 3
HEL702
Epididymis Luminal Protein 702

External Ids:    HGNC: 73731   Entrez Gene: 44782   Ensembl: ENSG000001470657   OMIM: 3098455   UniProtKB: P260383   

Export aliases for MSN gene to outside databases

Previous GC identifers: GC0XP061107 GC0XP062352 GC0XP063120 GC0XP063754 GC0XP064670 GC0XP064804 GC0XP058715


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSN Gene:
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and
radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons.
Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition
and signaling and for cell movement. (provided by RefSeq, Jul 2008)

GeneCards Summary for MSN Gene:
MSN (moesin) is a protein-coding gene. Diseases associated with MSN include measles. GO annotations related to this gene include protein kinase binding and structural constituent of cytoskeleton. An important paralog of this gene is MYLIP.

UniProtKB/Swiss-Prot: MOES_HUMAN, P26038
Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit
herpes simplex virus 1 infection at an early stage

Gene Wiki entry for MSN (Moesin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSN gene promoter:
         NF-1   NF-1/L   AML1a   p53   Ik-3   c-Ets-1   GATA-2   CREB   FOXC1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSN promoter sequence
   Search Chromatin IP Primers for MSN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq11.1   Ensembl cytogenetic band:  Xq12   HGNC cytogenetic band: Xq11.1

MSN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSN gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP064887:  view genomic region     (about GC identifiers)

Start:
64,808,257 bp from pter      End:
64,961,793 bp from pter
Size:
153,537 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MOES_HUMAN, P26038 (See protein sequence)
Recommended Name: Moesin  
Size: 577 amino acids; 67820 Da
Subunit: In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By
similarity). Binds SLC9A3R1. Interacts with PPP1R16B. Interacts with PDZD8. Interacts with SELPLG and SYK;
mediates the activation of SYK by SELPLG
3 PDB 3D structures from and Proteopedia for MSN:
1E5W (3D)        1EF1 (3D)        1SGH (3D)    

Explore the universe of human proteins at neXtProt for MSN: NX_P26038

Explore proteomics data for MSN at MOPED

Post-translational modifications: 

  • Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2
    suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened
    conformation which is capable of actin and membrane-binding (By similarity). Phosphorylation on Thr-558 by STK10
    negatively regulates lymphocyte migration and polarization1
  • Ubiquitination2 at Lys35, Lys79, Lys83, Lys139, Lys209, Lys237, Lys296, Lys352, Lys448, Lys523
  • Modification sites at PhosphoSitePlus

  • See MSN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002435.1  
    ENSEMBL proteins: 
     ENSP00000477441   ENSP00000353408  
    Reactome Protein details: P26038

    MSN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MSN Proteins
    Novus Biologicals MSN Lysates
    Sino Biological Recombinant Protein for MSN
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MSN

     
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    MSN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MSN
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MSN  (moesin)
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    LSBio Antibodies in human, mouse, rat for MSN

    MSN Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MSN
    Cloud-Clone Corp. CLIAs for MSN
    Search eBioscience for ELISAs for MSN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR000798 Ez/rad/moesin_like
     IPR008954 Moesin_tail
     IPR019747 FERM_CS

    Graphical View of Domain Structure for InterPro Entry P26038

    ProtoNet protein and cluster: P26038

    2 Blocks protein domains:
    IPB000299 Band 4.1 domain
    IPB000798 ERM family signature


    UniProtKB/Swiss-Prot: MOES_HUMAN, P26038
    Similarity: Contains 1 FERM domain


    Find genes that share domains with MSN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOES_HUMAN, P26038
    Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit
    herpes simplex virus 1 infection at an early stage
    Enzyme regulation: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed
    conformation (inactive form) which is incapable of actin or membrane-binding (By similarity)

         Genatlas biochemistry entry for MSN:
    moesin,filopodial protein involved in cell recognition,cell movement and morphological changes,membrane-organizing
    extension spike protein,ezrin/moesin/radixin-like moesin (ERM) family member responding and participating in
    reorganization of membrane-cytoplasmic interactions,and in regulation of linkage of the cytoskeleton to the
    plasma membrane,interacting with the cytoplasmic region of ICAM3 and redistributed to the uropod of T lymphocytes
    during cell polarization

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA--
    GO:0003779actin binding IEA--
    GO:0005102receptor binding IPI15819698
    GO:0005200structural constituent of cytoskeleton TAS1924289
    GO:0005515protein binding IPI10806479
         
    Find genes that share ontologies with MSN           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MSN:
     Decreased focal adhesion (FA)   Increased S DNA content  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Msn):
     normal 

    Find genes that share phenotypes with MSN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Msntm1Sts for MSN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSN

    miRNA
    Products:
        
    miRTarBase miRNAs that target MSN:
    hsa-mir-215-5p (MIRT024781), hsa-mir-133a-3p (MIRT006680), hsa-mir-192-5p (MIRT004153), hsa-mir-200c-3p (MIRT006433), hsa-mir-615-3p (MIRT040059), hsa-let-7b-5p (MIRT052198), hsa-mir-124-3p (MIRT022862)

    Block miRNA regulation of human, mouse, rat MSN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSN (see all 32):
    hsa-miR-217 hsa-miR-3149 hsa-miR-429 hsa-miR-1914* hsa-miR-513a-5p hsa-miR-1271 hsa-miR-765 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidMSN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MSN

    Gene Editing
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    Addgene plasmids for MSN 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOES_HUMAN, P26038: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm,
    cytoskeleton (By similarity). Apical cell membrane; Peripheral membrane protein; Cytoplasmic side (By
    similarity). Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side (By
    similarity). Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By
    similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after
    thrombin treatment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    plasma membrane5
    nucleus4
    cytosol3
    endosome1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001931uropod IEA--
    GO:0005634nucleus ----
    GO:0005730nucleolus ----
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton TAS16130169

    Find genes that share ontologies with MSN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MSN About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    3ERK Signaling
    Rho Family GTPases0.61
    4Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    5Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35


    Find genes that share SuperPaths with MSN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MSN
        RhoA Pathway
    Rho Family GTPases
    Transendothelial Migration of Leukocytes

    1 Cell Signaling Technology (CST) Pathway for MSN
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for MSN
        Cell adhesion ECM remodeling

    5 BioSystems Pathways for MSN
        AGE/RAGE pathway
    Regulation of Actin Cytoskeleton
    Glial Cell Differentiation
    Plasma membrane estrogen receptor signaling
    RhoA signaling pathway


    1 Reactome Pathway for MSN
        Recycling pathway of L1


    4 Kegg Pathways  (Kegg details for MSN):
        Leukocyte transendothelial migration
    Regulation of actin cytoskeleton
    Measles
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MSN: 
              Cytoskeleton Regulators in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MSN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MSN (P260381, 2, 3 ENSP000003534084) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434052, 3, ENSP000003648984MINT-8027874 MINT-8028505 I2D: score=3 STRING: ENSP00000364898
    SLC9A3R1O147451, 3, ENSP000002626134EBI-528768,EBI-349787 I2D: score=5 STRING: ENSP00000262613
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    HLA-CP305043I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0007159leukocyte cell-cell adhesion IEP12082081
    GO:0010628positive regulation of gene expression IGI--
    GO:0022614membrane to membrane docking IEP12082081
    GO:0050900leukocyte migration IEP12082081

    Find genes that share ontologies with MSN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSN (MOES)

    Selected Novoseek inferred chemical compound relationships for MSN gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 40.9 7 17428844 (2), 11387207 (1), 10947843 (1), 10085250 (1) (see all 6)
    tyrosine 40.4 15 11587846 (1), 10820377 (1), 15277531 (1), 17024180 (1) (see all 13)
    pip2 39.4 2 19204146 (1)
    phosphatidylinositol 28.6 7 9516463 (2), 16054017 (1), 17827228 (1), 19047065 (1)
    phosphotyrosine 26.8 3 1382070 (1), 12535520 (1), 7588875 (1)
    phosphoinositide 26.2 3 15047866 (1), 19204146 (1)
    gdp 23.8 2 18084788 (1), 9287351 (1)
    calyculin a 18.1 2 10436021 (1), 10480873 (1)
    orthophosphate 12.2 1 7588875 (1)
    hyaluronic acid 2.85 1 15326184 (1)



    Find genes that share compounds with MSN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MSN gene: 
    NM_002444.2  

    Unigene Cluster for MSN:

    Moesin
    Hs.87752  [show with all ESTs]
    Unigene Representative Sequence: NM_002444
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000609672 ENST00000439474(uc004dwe.3) ENST00000609205 ENST00000429601
    ENST00000447323 ENST00000360270(uc010nkp.1 uc004dwf.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MSN (see all 32):
    hsa-miR-217 hsa-miR-3149 hsa-miR-429 hsa-miR-1914* hsa-miR-513a-5p hsa-miR-1271 hsa-miR-765 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidMSN 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for MSN 
    Primer
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    OriGene qPCR primer pairs and template standards for MSN
    OriGene qSTAR qPCR primer pairs in human, mouse for MSN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSN
      QuantiTect SYBR Green Assays in human, mouse, rat MSN
      QuantiFast Probe-based Assays in human, mouse, rat MSN

    Additional mRNA sequence: 

    AK297165.1 AK308486.1 AK309986.1 BC001112.2 BC011827.2 BC017293.2 M69066.1 

    Selected DOTS entries (see all 26):

    DT.454352  DT.97856806  DT.100652334  DT.91691374  DT.92454839  DT.121279510  DT.95237879  DT.309113 
    DT.91749996  DT.92454840  DT.95237870  DT.100824187  DT.121279517  DT.121279518  DT.121279521  DT.121279584 
    DT.121279595  DT.91653693  DT.91734180  DT.95088616  DT.95237878  DT.95257852  DT.120883326  DT.75123048 

    Selected AceView cDNA sequences (see all 658):

    BU681543 BX424827 BC001112 BM806196 AA805129 BQ027086 BM557860 AI796599 
    BU687620 BU529113 BQ931613 BE409045 BM466233 CD614824 BP368350 CN479345 
    BQ575073 BQ722227 BM551834 AA587286 CA388863 BQ301617 BQ233448 AA355109 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MSN    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:              -     -     -     -                                                                                             
    SP2:              -     -                                                                                                         
    SP3:                          -     -                                                                                             
    SP4:                    -     -     -                                                                                             


    ECgene alternative splicing isoforms for MSN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MSN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTATTTCA
    MSN Expression
    About this image


    MSN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Ectoderm (Nervous System)    fully expand to see all 2 entries
             Spinal Neural Plate Cells Neural Plate
             Neural Plate
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MSN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.87752

    UniProtKB/Swiss-Prot: MOES_HUMAN, P26038
    Tissue specificity: In all tissues and cultured cells studied

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MSN: 
              Cytoskeleton Regulators in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MSN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msn1 , 5 moesin1, 5 92.09(n)1
    98.61(a)1
      X (42.65 cM)5
    176981  NM_010833.21  NP_034963.21 
     960960425 
    chicken
    (Gallus gallus)
    Aves MSN6
    moesin
    94(a)
    1 ↔ 1
    4(126218-163200)
    lizard
    (Anolis carolinensis)
    Reptilia MSN6
    moesin
    93(a)
    1 ↔ 1
    GL343465.1(513064-532246)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ724042.12   -- 82.51(n)    BQ724042.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049479.12   -- 81.09(n)    BC049479.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Moe1 , 3 establishment and/or maintenance of
    epithelial more3
    Moesin1
    59(a)
    (best of 2)3
    65(n)1
    63.57(a)1
      318161  NM_001272432.11  NP_001259361.11 
    worm
    (Caenorhabditis elegans)
    Secernentea erm-11 , 3 membrane protein3
    erm-11
    54(a)
    (best of 2)3
    59.14(n)1
    59.74(a)1
      I(5284602-5291512)3
    1721741  NM_059158.61  NP_491559.11 


    ENSEMBL Gene Tree for MSN (if available)
    TreeFam Gene Tree for MSN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSN gene
    MYLIP2  FRMD4A2  FRMD4B2  NF22  RDX2  EZR2  C1orf1062  
    15 SIMAP similar genes for MSN using alignment to 3 protein entries:     MOES_HUMAN (see all proteins):
    EZR-ROS1    RDX    VIL2    EZR    NF2    FARP2
    FRMD4B    FRMD4A    EPB41L3    PTPN3    PTPN4    EPB41L4A
    EPB41    EPB41L2    FARP1

    Find genes that share paralogs with MSN           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MSN
    PGOHUM00000235534


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSN (see all 919)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70504571,2
    C,F,H--64893378(+) tccagT/Accttt 1 -- us2k16Minor allele frequency- A:0.21NS EA WA CSA 421
    rs1496091051,2
    --64893446(+) CATAGC/TGGTCA 1 -- us2k10--------
    rs70505921,2
    C,F,A,H--64893452(+) ggtcaT/Caggat 1 -- us2k115Minor allele frequency- C:0.46NS EA NA WA CSA 1548
    rs1487954251,2
    --64893478(+) CTATAC/TGTAGA 1 -- us2k10--------
    rs1424833371,2
    --64893538(+) CTTACA/CATCTG 1 -- us2k10--------
    rs1835025121,2
    --64893589(+) ACATGA/GTTGCC 1 -- us2k10--------
    rs1874671941,2
    --64893662(+) TATTTC/TACTTT 1 -- us2k10--------
    rs1477597121,2
    C--64893677(+) GGAGAC/TGGAGT 1 -- us2k10--------
    rs70635451,2
    C,F,A--64893725(+) tctggA/Gctcag 1 -- us2k13Minor allele frequency- G:0.40NA WA CSA 5
    rs1907007091,2
    --64893775(+) CCTCCC/TGAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MSN (64808257 - 64961793 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MSN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1584074OTHER Inversion17803354

    Locus Specific Mutation Databases (LSDB): MSN

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSN
    DNA2.0 Custom Variant and Variant Library Synthesis for MSN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 309845    OMIM disorders: --

    1 disease for MSN:    
    About MalaCards
    measles

    1 disease from the University of Copenhagen DISEASES database for MSN:
    Neurofibromatosis

    Find genes that share disorders with MSN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MSN gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 86.1 6 8666669 (1), 9553042 (1), 11438984 (1), 9647651 (1) (see all 6)
    schwannoma 54 5 9403715 (3), 9811451 (1), 11368764 (1)
    meningioma 51.5 3 8586465 (1), 8808698 (1), 11368764 (1)
    tumors 38.7 43 8666669 (2), 11092524 (2), 9403715 (2), 9553042 (1) (see all 30)
    measles 32.8 14 8259662 (3), 9445061 (2), 8083969 (2), 7884872 (2) (see all 8)
    carcinoma verrucous 29 4 12787041 (2), 9696288 (2)
    breast carcinoma 25.7 3 9706140 (1), 17594689 (1)
    anaplastic large cell lymphoma 25.1 1 11310834 (1)
    neuroma acoustic 21.8 1 8586465 (1)
    wiskott-aldrich syndrome 18.7 1 8125014 (1)

    Genetic Association Database (GAD): MSN

    Export disorders for MSN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSN gene, integrated from 10 sources (see all 401):
    (articles sorted by number of sources associating them with MSN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Moesin: a member of the protein 4.1-talin-ezrin family of proteins. (PubMed id 1924289)1, 2, 3, 9 Lankes W.T. and Furthmayr H. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts. (PubMed id 7628534)1, 3, 9 Amieva M.R. and Furthmayr H. (Exp. Cell Res. 1995)
    3. Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. (PubMed id 9314537)1, 2, 9 Reczek D.... Bretscher A. (J. Cell Biol. 1997)
    4. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PubMed id 12387735)1, 2, 9 Urzainqui A....Sanchez-Madrid F. (Immunity 2002)
    5. PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1. (PubMed id 21549406)1, 2 Henning M.S.... Naghavi M.H. (Virology 2011)
    6. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. (PubMed id 19255442)1, 2 Belkina N.V.... Shaw S. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    8. The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain. (PubMed id 15020681)1, 2 Finnerty C.M....Bretscher A. (J. Cell Sci. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4478 HGNC: 7373 AceView: MSN Ensembl:ENSG00000147065 euGenes: HUgn4478
    ECgene: MSN Kegg: 4478 H-InvDB: MSN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSN gene:
    Search GeneIP for patents involving MSN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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