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Aliases for MSMP Gene

Aliases for MSMP Gene

  • Microseminoprotein, Prostate Associated 2 3 5
  • PSMP 3 4
  • PC3 Prostate Cancer Cell-Secreted Microprotein 3
  • Prostate-Associated Microseminoprotein 3
  • PC3-Secreted Microprotein 4

External Ids for MSMP Gene

Summaries for MSMP Gene

Entrez Gene Summary for MSMP Gene

  • This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in prostate cancer tumorigenesis. [provided by RefSeq, Jan 2011]

GeneCards Summary for MSMP Gene

MSMP (Microseminoprotein, Prostate Associated) is a Protein Coding gene. Diseases associated with MSMP include Prostate Cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSMP Gene

Genomics for MSMP Gene

Regulatory Elements for MSMP Gene

Enhancers for MSMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F035726 1.5 FANTOM5 ENCODE 11.6 +26.2 26199 8.6 MLX CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TMEM8B GBA2 TPM2 RGP1 TLN1 ARHGEF39 RN7SL22P CCDC107 ENSG00000228843 MSMP
GH09F035904 1.6 FANTOM5 Ensembl ENCODE 9.4 -151.5 -151488 7.8 SIN3A ZNF48 YY1 SLC30A9 ZNF121 GLIS2 FOS ZNF263 SP3 REST HRCT1 LINC00961 TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
GH09F035679 1.2 Ensembl ENCODE 10.9 +70.5 70496 12.8 PKNOX1 ARID4B SIN3A GLIS2 ELK1 FOS ZNF263 SP3 SMARCB1 MBD2 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 MIR6852 RGP1
GH09F035913 1.3 Ensembl ENCODE 9.9 -160.5 -160538 7.9 HDGF PKNOX1 ATF1 ARNT ARID4B YBX1 ZNF48 YY1 ZNF766 ELK1 CREB3 SPAG8 YBX1P10 GBA2 LINC00961 RECK NDUFA5P4 FAM221B OR13J1 TMEM8B
GH09F035825 1 Ensembl ENCODE 10.9 -69.9 -69867 1.0 HDGF CTCF SUZ12 IRF3 RAD21 ZNF143 SMC3 ZBTB20 MIXL1 STAT1 ENSG00000227388 NPR2 ENSG00000228843 MSMP GBA2 RGP1 CREB3 MIR6852 TLN1 OR13J1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MSMP on UCSC Golden Path with GeneCards custom track

Promoters for MSMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001302873 -687 1401 HDGF CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF766

Genomic Location for MSMP Gene

Chromosome:
9
Start:
35,752,990 bp from pter
End:
35,756,613 bp from pter
Size:
3,624 bases
Orientation:
Minus strand

Genomic View for MSMP Gene

Genes around MSMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSMP Gene

Proteins for MSMP Gene

  • Protein details for MSMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1L6U9-MSMP_HUMAN
    Recommended name:
    Prostate-associated microseminoprotein
    Protein Accession:
    Q1L6U9

    Protein attributes for MSMP Gene

    Size:
    139 amino acids
    Molecular mass:
    14993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MSMP Gene

Post-translational modifications for MSMP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSMP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSMP Gene

Domains & Families for MSMP Gene

Protein Domains for MSMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1L6U9

UniProtKB/Swiss-Prot:

MSMP_HUMAN :
  • Belongs to the beta-microseminoprotein family.
Family:
  • Belongs to the beta-microseminoprotein family.
genes like me logo Genes that share domains with MSMP: view

No data available for Gene Families for MSMP Gene

Function for MSMP Gene

Gene Ontology (GO) - Molecular Function for MSMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MSMP: view

Phenotypes for MSMP Gene

GenomeRNAi human phenotypes for MSMP:
genes like me logo Genes that share phenotypes with MSMP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MSMP Gene

Localization for MSMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSMP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSMP gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MSMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 17338636
GO:0005737 cytoplasm IDA 17338636
genes like me logo Genes that share ontologies with MSMP: view

Pathways & Interactions for MSMP Gene

No Data Available

Interacting Proteins for MSMP Gene

Gene Ontology (GO) - Biological Process for MSMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MSMP: view

No data available for Pathways by source and SIGNOR curated interactions for MSMP Gene

Transcripts for MSMP Gene

mRNA/cDNA for MSMP Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MSMP Gene

Microseminoprotein, prostate associated:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSMP Gene

No ASD Table

Relevant External Links for MSMP Gene

GeneLoc Exon Structure for
MSMP
ECgene alternative splicing isoforms for
MSMP

Expression for MSMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MSMP Gene

mRNA expression in normal human tissues for MSMP Gene

Protein differential expression in normal tissues from HIPED for MSMP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MSMP Gene



Protein tissue co-expression partners for MSMP Gene

NURSA nuclear receptor signaling pathways regulating expression of MSMP Gene:

MSMP

SOURCE GeneReport for Unigene cluster for MSMP Gene:

Hs.571601

mRNA Expression by UniProt/SwissProt for MSMP Gene:

Q1L6U9-MSMP_HUMAN
Tissue specificity: Detected in prostate epithelium (at protein level). Detected in trachea and testis. Highly expressed in the human prostate cancer cell line PC-3.
genes like me logo Genes that share expression patterns with MSMP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MSMP Gene

Orthologs for MSMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSMP 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia MSMP 34 35
  • 93.29 (n)
rat
(Rattus norvegicus)
Mammalia LOC100365008 34
  • 89.69 (n)
cow
(Bos Taurus)
Mammalia MSMP 34 35
  • 89.45 (n)
mouse
(Mus musculus)
Mammalia Msmp 34 16 35
  • 88.49 (n)
oppossum
(Monodelphis domestica)
Mammalia MSMP 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSMP 34 35
  • 66.14 (n)
lizard
(Anolis carolinensis)
Reptilia MSMP 35
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101884672 34
  • 62.27 (n)
MSMP 35
  • 28 (a)
OneToOne
Species where no ortholog for MSMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSMP Gene

ENSEMBL:
Gene Tree for MSMP (if available)
TreeFam:
Gene Tree for MSMP (if available)

Paralogs for MSMP Gene

No data available for Paralogs for MSMP Gene

Variants for MSMP Gene

Sequence variations from dbSNP and Humsavar for MSMP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs112202528 -- 35,753,265(+) AAGTC(A/G)ATGGG reference, synonymous-codon, utr-variant-3-prime, utr-variant-5-prime
rs113248660 -- 35,754,751(+) TTTCC(C/T)TCAGA upstream-variant-2KB, utr-variant-5-prime
rs116619039 -- 35,753,646(+) GCCAT(C/T)TTTGG intron-variant, downstream-variant-500B, utr-variant-5-prime
rs1322045 -- 35,754,503(+) GGGGC(A/G)AGGGC upstream-variant-2KB, utr-variant-5-prime
rs137923089 -- 35,752,593(+) CTGTC(A/G)TTGGC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MSMP Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259

Variation tolerance for MSMP Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSMP Gene

Disorders for MSMP Gene

MalaCards: The human disease database

(1) MalaCards diseases for MSMP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search MSMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for MSMP

Genetic Association Database (GAD)
MSMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSMP
genes like me logo Genes that share disorders with MSMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSMP Gene

Publications for MSMP Gene

  1. A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue. (PMID: 17338636) Valtonen-Andre C. … Lundwall A. (Biol. Chem. 2007) 2 3 4 64
  2. PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2. (PMID: 24442440) Pei X. … Wang Y. (J. Immunol. 2014) 3 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. (PMID: 11053263) Gonzalez P. … BorrA!s T. (Invest. Ophthalmol. Vis. Sci. 2000) 3 64

Products for MSMP Gene

Sources for MSMP Gene

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