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Aliases for MSMP Gene

Aliases for MSMP Gene

  • Microseminoprotein, Prostate Associated 2 3 5
  • PSMP 3 4
  • PC3 Prostate Cancer Cell-Secreted Microprotein 3
  • Prostate-Associated Microseminoprotein 3
  • PC3-Secreted Microprotein 4

External Ids for MSMP Gene

Summaries for MSMP Gene

Entrez Gene Summary for MSMP Gene

  • This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in prostate cancer tumorigenesis. [provided by RefSeq, Jan 2011]

GeneCards Summary for MSMP Gene

MSMP (Microseminoprotein, Prostate Associated) is a Protein Coding gene. Diseases associated with MSMP include Prostate Cancer and Colonic Benign Neoplasm.

Additional gene information for MSMP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSMP Gene

Genomics for MSMP Gene

GeneHancer (GH) Regulatory Elements for MSMP Gene

Promoters and enhancers for MSMP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I035755 Promoter/Enhancer 1.5 Ensembl ENCODE 550.8 -0.8 -807 3.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 IRF4 ZNF48 ENSG00000228843 MSMP TMEM8B NPR2 HRCT1 PHF24 RGP1
GH09I035754 Promoter 0.7 EPDnew 550.8 +2.3 2318 0.1 GLIS1 ZIC2 GC09P035757 MSMP PIR50666 NPR2 RGP1
GH09I035726 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 +26.2 26198 8.6 YBX1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D TLN1 CREB3 TMEM8B GBA2 ARHGEF39 TPM2 HMGB3P24 PIGO RN7SL22P ENSG00000228843
GH09I035679 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 +70.5 70496 12.8 PKNOX1 ARID4B SIN3A POLR2B GLIS2 FOS SP3 REST SMARCB1 MIER3 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 RGP1 MSMP
GH09I035616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 10.4 +137.4 137359 6.4 HDGF PKNOX1 ATF1 SMAD1 RB1 SIN3A BATF RFX5 ETS1 SCRT2 CD72 CCDC107 RN7SL22P ARHGEF39 SIT1 CA9 FAM166B TLN1 CREB3 GBA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MSMP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MSMP gene promoter:

Genomic Locations for MSMP Gene

Genomic Locations for MSMP Gene
chr9:35,752,990-35,756,613
(GRCh38/hg38)
Size:
3,624 bases
Orientation:
Minus strand
chr9:35,752,987-35,756,610
(GRCh37/hg19)

Genomic View for MSMP Gene

Genes around MSMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSMP Gene

Proteins for MSMP Gene

  • Protein details for MSMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1L6U9-MSMP_HUMAN
    Recommended name:
    Prostate-associated microseminoprotein
    Protein Accession:
    Q1L6U9

    Protein attributes for MSMP Gene

    Size:
    139 amino acids
    Molecular mass:
    14993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MSMP Gene

Post-translational modifications for MSMP Gene

No Post-translational modifications

Other Protein References for MSMP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSMP Gene

Domains & Families for MSMP Gene

Gene Families for MSMP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MSMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1L6U9

UniProtKB/Swiss-Prot:

MSMP_HUMAN :
  • Belongs to the beta-microseminoprotein family.
Family:
  • Belongs to the beta-microseminoprotein family.
genes like me logo Genes that share domains with MSMP: view

Function for MSMP Gene

Phenotypes From GWAS Catalog for MSMP Gene

Gene Ontology (GO) - Molecular Function for MSMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MSMP: view

Phenotypes for MSMP Gene

GenomeRNAi human phenotypes for MSMP:
genes like me logo Genes that share phenotypes with MSMP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MSMP Gene

Localization for MSMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSMP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSMP gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MSMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 17338636
GO:0005737 cytoplasm IDA 17338636
genes like me logo Genes that share ontologies with MSMP: view

Pathways & Interactions for MSMP Gene

No Data Available

Interacting Proteins for MSMP Gene

Gene Ontology (GO) - Biological Process for MSMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MSMP: view

No data available for Pathways by source and SIGNOR curated interactions for MSMP Gene

Drugs & Compounds for MSMP Gene

No Compound Related Data Available

Transcripts for MSMP Gene

mRNA/cDNA for MSMP Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MSMP Gene

Microseminoprotein, prostate associated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSMP Gene

No ASD Table

Relevant External Links for MSMP Gene

GeneLoc Exon Structure for
MSMP
ECgene alternative splicing isoforms for
MSMP

Expression for MSMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSMP Gene

mRNA expression in normal human tissues for MSMP Gene

Protein differential expression in normal tissues from HIPED for MSMP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MSMP Gene



Protein tissue co-expression partners for MSMP Gene

NURSA nuclear receptor signaling pathways regulating expression of MSMP Gene:

MSMP

SOURCE GeneReport for Unigene cluster for MSMP Gene:

Hs.571601

mRNA Expression by UniProt/SwissProt for MSMP Gene:

Q1L6U9-MSMP_HUMAN
Tissue specificity: Detected in prostate epithelium (at protein level). Detected in trachea and testis. Highly expressed in the human prostate cancer cell line PC-3.
genes like me logo Genes that share expression patterns with MSMP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSMP Gene

Orthologs for MSMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSMP 33 34
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia MSMP 33 34
  • 93.29 (n)
rat
(Rattus norvegicus)
Mammalia LOC100365008 33
  • 89.69 (n)
cow
(Bos Taurus)
Mammalia MSMP 33 34
  • 89.45 (n)
mouse
(Mus musculus)
Mammalia Msmp 33 16 34
  • 88.49 (n)
oppossum
(Monodelphis domestica)
Mammalia MSMP 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSMP 33 34
  • 66.14 (n)
lizard
(Anolis carolinensis)
Reptilia MSMP 34
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101884672 33
  • 62.27 (n)
MSMP 34
  • 28 (a)
OneToOne
Species where no ortholog for MSMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSMP Gene

ENSEMBL:
Gene Tree for MSMP (if available)
TreeFam:
Gene Tree for MSMP (if available)

Paralogs for MSMP Gene

No data available for Paralogs for MSMP Gene

Variants for MSMP Gene

Sequence variations from dbSNP and Humsavar for MSMP Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000699518 -- 35,753,765(-) G/A coding_sequence_variant, missense_variant
rs1000751991 -- 35,753,433(-) G/A intron_variant
rs1001878224 -- 35,754,461(-) G/A upstream_transcript_variant
rs1002022904 -- 35,752,965(-) A/C downstream_transcript_variant
rs1002918738 -- 35,752,970(-) G/A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MSMP Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259

Variation tolerance for MSMP Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MSMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSMP Gene

Disorders for MSMP Gene

MalaCards: The human disease database

(2) MalaCards diseases for MSMP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search MSMP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MSMP

genes like me logo Genes that share disorders with MSMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSMP Gene

Publications for MSMP Gene

  1. A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue. (PMID: 17338636) Valtonen-André C … Lundwall A (Biological chemistry 2007) 2 3 4 58
  2. PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2. (PMID: 24442440) Pei X … Wang Y (Journal of immunology (Baltimore, Md. : 1950) 2014) 3 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. (PMID: 11053263) Gonzalez P … Borrás T (Investigative ophthalmology & visual science 2000) 3 58

Products for MSMP Gene

Sources for MSMP Gene

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