MSMP Gene
protein-coding GIFtS: 31
GCID: GC09M035743
|
|
microseminoprotein, prostate associated
| |
Aliases
for MSMP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Microseminoprotein, Prostate Associated1 2 | | PSMP1 2 3 5 | | PC-31 | | PC3 Prostate Cancer Cell-Secreted Microprotein2 | | Prostate-Associated Microseminoprotein2 | | PC3-Secreted Microprotein3 |
Export aliases for MSMP gene to outside databases |
Summaries
for MSMP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MSMP:
This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conservedcysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in prostate cancertumorigenesis. (provided by RefSeq, Jan 2011)
|
Genomic Views
for MSMP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MSMP gene promoter:
AP-2alpha isoform 3 Nkx2-5 AP-2alpha isoform 2 SREBP-1b GATA-1 SREBP-1a AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for MSMP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSMP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3MSMP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M035743: view genomic region
(about GC identifiers)
Start:
|
35,752,987 bp from pter |
End:
|
35,756,610 bp from pter |
Size:
|
3,624 bases |
Orientation:
|
minus strand |
|
Proteins
for MSMP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MSMP_HUMAN, Q1L6U9 (See
protein sequence)Recommended Name: Prostate-associated microseminoprotein precursor Size: 139 amino acids; 14993 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for MSMP: NX_Q1L6U9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q1L6U9
MSMP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001037729.1
ENSEMBL proteins: ENSP00000419194
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
MSMP for ontologies About GeneDecksing
MSMP Antibody Products:
Assay Products for MSMP: |
Protein
Domains /
Families
for MSMP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MSMP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q1L6U9ProtoNet protein and cluster: Q1L6U9 UniProtKB/Swiss-Prot: MSMP_HUMAN, Q1L6U9Similarity: Belongs to the beta-microseminoprotein family |
Function
for MSMP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSMP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSMP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MSMP (NM_001044264) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MSMP | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MSMP |
|
Pathways & Interactions
for MSMP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSMP
|
Drugs & Compounds
for MSMP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MSMP
Search CenterWatch for drugs/clinical trials and news about MSMP
|
Transcripts
for MSMP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MSMP gene: NM_001044264.2 Unigene Cluster for MSMP: Microseminoprotein, prostate associated Hs.571601 [show with all ESTs]Unigene Representative Sequence: BG1781412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000436428(uc003zyb.2) ENST00000414286
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSMP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSMP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MSMP (NM_001044264) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MSMP | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MSMP |
Additional cDNA sequence: BC071800.1 BC105274.1 DQ012170.1 5 DOTS entries: DT.99994007 DT.95259910 DT.92441757 DT.312135 DT.92451593
GeneLoc Exon Structure
|
Expression
for MSMP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MSMP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MSMP Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.571601
UniProtKB/Swiss-Prot: MSMP_HUMAN, Q1L6U9Tissue specificity: Detected in prostate epithelium (at protein level). Detected in trachea and testis. Highlyexpressed in the human prostate cancer cell line PC-3
SABiosciences Custom PCR Arrays for MSMP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSMP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSMP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSMP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSMP |
Orthologs
for MSMP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MSMP gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for MSMP (if available)
TreeFam Gene Tree for MSMP (if available) |
Paralogs
for MSMP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MSMP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MSMP (35752987 - 35756610 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MSMP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSMP |
|
Disorders
/ Diseases
for MSMP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MSMP for disorders About GeneDecksing
OMIM gene information: 612191
OMIM disorders: --
2  diseases for MSMP: About MalaCardsprostate cancer prostatitis
Export disorders for MSMP gene to outside databases
|
Publications
for MSMP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MSMP gene integrated from 9 sources:
(articles sorted by number of sources associating them with MSMP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue. (PubMed id 17338636)1, 2, 3 Valtonen-Andre C....Lundwall A. (2007)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. (PubMed id 11053263)1 Gonzalez P....Borras T. (2000)
|
External Searches for MSMP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MSMP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MSMP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MSMP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MSMP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MSMP gene:
Search GeneIP for patents involving MSMP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MSMP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MSMP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSMP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSMP | | | OriGene Protein Over-expression Lysate for MSMP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MSMP | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSMP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSMP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MSMP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MSMP | | OriGene Custom Protein Services for MSMP | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MSMP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSMP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSMP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSMP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSMP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSMP |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MSMP |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MSMP Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MSMP |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MSMP |
|
|
|
|
