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Aliases for MSMP Gene

Aliases for MSMP Gene

  • Microseminoprotein, Prostate Associated 2 3 5
  • PSMP 3 4
  • PC3 Prostate Cancer Cell-Secreted Microprotein 3
  • PC3-Secreted Microprotein 4

External Ids for MSMP Gene

Summaries for MSMP Gene

Entrez Gene Summary for MSMP Gene

  • This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in prostate cancer tumorigenesis. [provided by RefSeq, Jan 2011]

GeneCards Summary for MSMP Gene

MSMP (Microseminoprotein, Prostate Associated) is a Protein Coding gene. Diseases associated with MSMP include prostate cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSMP Gene

Genomics for MSMP Gene

Genomic Location for MSMP Gene

Chromosome:
9
Start:
35,752,990 bp from pter
End:
35,756,613 bp from pter
Size:
3,624 bases
Orientation:
Minus strand

Genomic View for MSMP Gene

Genes around MSMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSMP Gene

Proteins for MSMP Gene

  • Protein details for MSMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1L6U9-MSMP_HUMAN
    Recommended name:
    Prostate-associated microseminoprotein
    Protein Accession:
    Q1L6U9

    Protein attributes for MSMP Gene

    Size:
    139 amino acids
    Molecular mass:
    14993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MSMP Gene

Proteomics data for MSMP Gene at MOPED

Post-translational modifications for MSMP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSMP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSMP Gene

Domains & Families for MSMP Gene

Protein Domains for MSMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1L6U9

UniProtKB/Swiss-Prot:

MSMP_HUMAN :
  • Belongs to the beta-microseminoprotein family.
Family:
  • Belongs to the beta-microseminoprotein family.
genes like me logo Genes that share domains with MSMP: view

No data available for Gene Families for MSMP Gene

Function for MSMP Gene

Phenotypes for MSMP Gene

GenomeRNAi human phenotypes for MSMP:
genes like me logo Genes that share phenotypes with MSMP: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MSMP Gene

Localization for MSMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSMP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSMP Gene COMPARTMENTS Subcellular localization image for MSMP gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for MSMP Gene

Pathways & Interactions for MSMP Gene

SuperPathways for MSMP Gene

No Data Available

Interacting Proteins for MSMP Gene

Gene Ontology (GO) - Biological Process for MSMP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MSMP Gene

Drugs & Compounds for MSMP Gene

No Compound Related Data Available

Transcripts for MSMP Gene

mRNA/cDNA for MSMP Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MSMP Gene

Microseminoprotein, prostate associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSMP Gene

No ASD Table

Relevant External Links for MSMP Gene

GeneLoc Exon Structure for
MSMP
ECgene alternative splicing isoforms for
MSMP

Expression for MSMP Gene

mRNA expression in normal human tissues for MSMP Gene

mRNA expression in normal human tissues for MSMP Gene

Protein differential expression in normal tissues from HIPED for MSMP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MSMP Gene



SOURCE GeneReport for Unigene cluster for MSMP Gene Hs.571601

mRNA Expression by UniProt/SwissProt for MSMP Gene

Q1L6U9-MSMP_HUMAN
Tissue specificity: Detected in prostate epithelium (at protein level). Detected in trachea and testis. Highly expressed in the human prostate cancer cell line PC-3.
genes like me logo Genes that share expression patterns with MSMP: view

Protein tissue co-expression partners for MSMP Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MSMP Gene

Orthologs for MSMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSMP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSMP 35
  • 89.45 (n)
  • 91.37 (a)
MSMP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSMP 35
  • 93.29 (n)
  • 93.53 (a)
MSMP 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msmp 35
  • 88.49 (n)
  • 91.37 (a)
Msmp 16
Msmp 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MSMP 35
  • 99.28 (n)
  • 99.28 (a)
MSMP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100365008 35
  • 89.69 (n)
  • 90.65 (a)
oppossum
(Monodelphis domestica)
Mammalia MSMP 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSMP 35
  • 66.14 (n)
  • 58.73 (a)
MSMP 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSMP 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101884672 35
  • 62.27 (n)
  • 56.04 (a)
MSMP 36
  • 28 (a)
OneToOne
Species with no ortholog for MSMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSMP Gene

ENSEMBL:
Gene Tree for MSMP (if available)
TreeFam:
Gene Tree for MSMP (if available)

Paralogs for MSMP Gene

No data available for Paralogs for MSMP Gene

Variants for MSMP Gene

Sequence variations from dbSNP and Humsavar for MSMP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_043818 -

Structural Variations from Database of Genomic Variants (DGV) for MSMP Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294

Variation tolerance for MSMP Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSMP Gene

HapMap Linkage Disequilibrium report
MSMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSMP Gene

Disorders for MSMP Gene

MalaCards: The human disease database

(1) MalaCards diseases for MSMP Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search MSMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for MSMP

Genetic Association Database (GAD)
MSMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSMP
genes like me logo Genes that share disorders with MSMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSMP Gene

Publications for MSMP Gene

  1. A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue. (PMID: 17338636) Valtonen-Andre C. … Lundwall A. (Biol. Chem. 2007) 2 3 4 67
  2. PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2. (PMID: 24442440) Pei X. … Wang Y. (J. Immunol. 2014) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. (PMID: 11053263) Gonzalez P. … BorrA!s T. (Invest. Ophthalmol. Vis. Sci. 2000) 3

Products for MSMP Gene

Sources for MSMP Gene

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