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Aliases for MSMO1 Gene

Aliases for MSMO1 Gene

  • Methylsterol Monooxygenase 1 2 3
  • SC4MOL 3 4 6
  • ERG25 3 4 6
  • C-4 Methylsterol Oxidase 3 4
  • DESP4 3 4
  • Sterol-C4-Methyl Oxidase-Like 2
  • C-4 Methyl Sterol 3
  • EC 1.14.13.72 4

External Ids for MSMO1 Gene

Previous Symbols for MSMO1 Gene

  • SC4MOL

Summaries for MSMO1 Gene

Entrez Gene Summary for MSMO1 Gene

  • Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSMO1 Gene

MSMO1 (Methylsterol Monooxygenase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include iron ion binding and C-4 methylsterol oxidase activity. An important paralog of this gene is FAXDC2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSMO1 Gene

Genomics for MSMO1 Gene

Genomic Location for MSMO1 Gene

Start:
165,327,623 bp from pter
End:
165,343,164 bp from pter
Size:
15,542 bases
Orientation:
Plus strand

Genomic View for MSMO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSMO1 Gene

No data available for Regulatory Elements for MSMO1 Gene

Proteins for MSMO1 Gene

  • Protein details for MSMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15800-MSMO1_HUMAN
    Recommended name:
    Methylsterol monooxygenase 1
    Protein Accession:
    Q15800
    Secondary Accessions:
    • A8K8Q3
    • A8MYF6
    • D3DP32
    • Q32Q24

    Protein attributes for MSMO1 Gene

    Size:
    293 amino acids
    Molecular mass:
    35216 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSMO1 Gene

Proteomics data for MSMO1 Gene at MOPED

Post-translational modifications for MSMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys87 and Lys284

Other Protein References for MSMO1 Gene

No data available for DME Specific Peptides for MSMO1 Gene

Domains for MSMO1 Gene

Gene Families for MSMO1 Gene

HGNC:
  • FATHD :Fatty acid hydroxylase domain containing

Protein Domains for MSMO1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MSMO1_HUMAN
Domain:
  • The histidine box domains may contain the active site and/or be involved in metal ion binding:
    • Q15800
Family:
  • Belongs to the sterol desaturase family.:
    • Q15800
genes like me logo Genes that share domains with MSMO1: view

Function for MSMO1 Gene

Molecular function for MSMO1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity: 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + 2 H(2)O
UniProtKB/Swiss-Prot CatalyticActivity: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + O(2) = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + H(2)O

Enzyme Numbers (IUBMB) for MSMO1 Gene

Gene Ontology (GO) - Molecular Function for MSMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000254 C-4 methylsterol oxidase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with MSMO1: view

Phenotypes for MSMO1 Gene

MGI mutant phenotypes for MSMO1:
inferred from 1 alleles
GenomeRNAi human phenotypes for MSMO1:
genes like me logo Genes that share phenotypes with MSMO1: view

miRNA for MSMO1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MSMO1 Gene

Localization for MSMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSMO1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MSMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 8663358
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS 8663358
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MSMO1: view

Pathways for MSMO1 Gene

genes like me logo Genes that share pathways with MSMO1: view

UniProtKB/Swiss-Prot Q15800-MSMO1_HUMAN

  • Pathway: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6

Gene Ontology (GO) - Biological Process for MSMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process TAS 8663358
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006695 cholesterol biosynthetic process TAS --
GO:0008202 steroid metabolic process TAS 8663358
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with MSMO1: view

Compounds for MSMO1 Gene

(3) Novoseek inferred chemical compound relationships for MSMO1 Gene

Compound -log(P) Hits PubMed IDs
ergosterol 77.8 2
sterol 54.5 1
iron 24.8 1
genes like me logo Genes that share compounds with MSMO1: view

Transcripts for MSMO1 Gene

Unigene Clusters for MSMO1 Gene

Methylsterol monooxygenase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSMO1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for MSMO1 Gene

GeneLoc Exon Structure for
MSMO1
ECgene alternative splicing isoforms for
MSMO1

Expression for MSMO1 Gene

mRNA expression in normal human tissues for MSMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSMO1 Gene

This gene is overexpressed in Liver (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSMO1 Gene

SOURCE GeneReport for Unigene cluster for MSMO1 Gene Hs.105269

genes like me logo Genes that share expressions with MSMO1: view

Orthologs for MSMO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MSMO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSMO1 36
  • 99.66 (n)
  • 100 (a)
MSMO1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSMO1 36
  • 92.38 (n)
  • 95.22 (a)
SC4MOL 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SC4MOL 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sc4mol 36
  • 82.94 (n)
  • 89.08 (a)
Sc4mol 16
Sc4mol 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSMO1 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSMO1 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msmo1 36
  • 83.28 (n)
  • 88.74 (a)
chicken
(Gallus gallus)
Aves MSMO1 36
  • 76.89 (n)
  • 83.97 (a)
MSMO1 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSMO1 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msmo1 36
  • 73.95 (n)
  • 78.5 (a)
zebrafish
(Danio rerio)
Actinopterygii msmo1 36
  • 72.03 (n)
  • 80.07 (a)
msmo1 37
  • 79 (a)
OneToOne
wufb59g06 36
worm
(Caenorhabditis elegans)
Secernentea F49E12.10 37
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG25 37
  • 35 (a)
OneToMany
ERG25 39
Species with no ortholog for MSMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSMO1 Gene

ENSEMBL:
Gene Tree for MSMO1 (if available)
TreeFam:
Gene Tree for MSMO1 (if available)

Paralogs for MSMO1 Gene

Paralogs for MSMO1 Gene

Pseudogenes.org Pseudogenes for MSMO1 Gene

genes like me logo Genes that share paralogs with MSMO1: view

Variants for MSMO1 Gene

Sequence variations from dbSNP and Humsavar for MSMO1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs8733 -- 165,342,967(+) TTTGT(A/G/T)TATCA utr-variant-3-prime
rs13918 -- 165,342,767(+) AAGCC(A/G)GCACC utr-variant-3-prime
rs756090 -- 165,337,089(+) TTTGT(A/T)AAGCC intron-variant
rs934815 -- 165,330,728(+) GAGAC(C/G)GAGTT intron-variant
rs934816 -- 165,336,454(+) ATACT(C/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSMO1 Gene

Variant ID Type Subtype PubMed ID
nsv289926 CNV Loss 16902084

Relevant External Links for MSMO1 Gene

HapMap Linkage Disequilibrium report
MSMO1
Human Gene Mutation Database (HGMD)
MSMO1

Disorders for MSMO1 Gene

No disorders were found for MSMO1 Gene.

No data available for UniProtKB/Swiss-Prot for MSMO1 Gene

Publications for MSMO1 Gene

  1. Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. (PMID: 8663358) Li L. … Kaplan J. (J. Biol. Chem. 1996) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3
  5. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PMID: 18781797) Meierhofer D. … Kaiser P. (J. Proteome Res. 2008) 3

Products for MSMO1 Gene

Sources for MSMO1 Gene

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