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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSMO1 Gene

protein-coding   GIFtS: 54
GCID: GC04P166249

Methylsterol Monooxygenase 1

(Previous name: sterol-C4-methyl oxidase-like)
(Previous symbol: SC4MOL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methylsterol Monooxygenase 11 2     C-4 Methylsterol Oxidase2 3
SC4MOL1 2 3 5     Sterol-C4-Methyl Oxidase-Like1
ERG252 3 5     C-4 Methyl Sterol2
DESP42 3     EC 1.14.13.723

External Ids:    HGNC: 105451   Entrez Gene: 63072   Ensembl: ENSG000000528027   OMIM: 6075455   UniProtKB: Q158003   

Export aliases for MSMO1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MSMO1 Gene:
Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains
a set of putative metal binding motifs with similarity to that seen in a family of membrane
desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to
function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have
been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MSMO1 Gene: 
MSMO1 (methylsterol monooxygenase 1) is a protein-coding gene. Diseases associated with MSMO1 include microcephaly, and dermatitis, and among its related super-pathways are Cholesterol biosynthesis and Metabolic pathways. GO annotations related to this gene include C-4 methylsterol oxidase activity and iron ion binding. An important paralog of this gene is CH25H.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MSMO1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSMO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSMO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32-q34   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32-q34

MSMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSMO1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P166249:  view genomic region     (about GC identifiers)

Start:
166,248,775 bp from pter      End:
166,264,312 bp from pter
Size:
15,538 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MSMO1_HUMAN, Q15800 (See protein sequence)
Recommended Name: Methylsterol monooxygenase 1  
Size: 293 amino acids; 35216 Da
Cofactor: Iron (Probable)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A8K8Q3 A8MYF6 D3DP32 Q32Q24
Alternative splicing: 2 isoforms:  Q15800-1   Q15800-2   

Explore the universe of human proteins at neXtProt for MSMO1: NX_Q15800

Explore proteomics data for MSMO1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15800

  • MSMO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MSMO1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001017369.1  NP_006736.1  

    ENSEMBL proteins: 
     ENSP00000261507   ENSP00000425241   ENSP00000377361   ENSP00000423633   ENSP00000425112  
    Reactome Protein details: Q15800
    Human Recombinant Protein Products for MSMO1: 
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    Novus Biologicals MSMO1 Protein
    Novus Biologicals MSMO1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS8663358
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane TAS8663358
    GO:0016021integral to membrane IEA--

    MSMO1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FATHD: Fatty acid hydroxylase domain containing

    1 InterPro protein domain:
     IPR006694 Fatty_acid_hydroxylase

    Graphical View of Domain Structure for InterPro Entry Q15800

    ProtoNet protein and cluster: Q15800

    1 Blocks protein domain: IPB006088 Sterol desaturase

    UniProtKB/Swiss-Prot: MSMO1_HUMAN, Q15800
    Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding
    Similarity: Belongs to the sterol desaturase family


    MSMO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSMO1_HUMAN, Q15800
    Catalytic activity: 4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) =
    4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O
    Catalytic activity: 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) =
    3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + 2 H(2)O
    Catalytic activity: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + O(2) =
    3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + H(2)O

         Enzyme Number (IUBMB): EC 1.14.13.721

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000254C-4 methylsterol oxidase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0016491oxidoreductase activity ----
         
    MSMO1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MSMO1:
     Increased S DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sc4mol):
     mortality/aging 

    MSMO1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MSMO1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MSMO1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1cholesterol biosynthesis III (via desmosterol)
    Cholesterol biosynthesis0.85
    cholesterol biosynthesis II (via 24,25-dihydrolanosterol)0.59
    superpathway of cholesterol biosynthesis0.85
    cholesterol biosynthesis I0.59
    Cholesterol biosynthesis0.62
    Steroid biosynthesis0.48
    cholesterol biosynthesis III (via desmosterol)0.59
    zymosterol biosynthesis0.46
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6 BioSystems Pathways for MSMO1 (see all 6)
        Cholesterol biosynthesis
    zymosterol biosynthesis
    cholesterol biosynthesis I
    superpathway of cholesterol biosynthesis
    cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

    3        Reactome Pathways for MSMO1
        Metabolism
    Cholesterol biosynthesis
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for MSMO1):
        Steroid biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MSMO1_HUMAN, Q15800
    Pathway: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6


    MSMO1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSMO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/93 Interacting proteins for MSMO1 (Q158002, 3 ENSP000002615074) via UniProtKB, MINT, STRING, and/or I2D (see all 93)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2862770 I2D: score=3 STRING: ENSP00000244769
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    ENSG00000228425Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process TAS8663358
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006695cholesterol biosynthetic process TAS--
    GO:0008202steroid metabolic process TAS8663358
    GO:0044281small molecule metabolic process TAS--

    MSMO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MSMO1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSMO1

    3 Novoseek inferred chemical compound relationships for MSMO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ergosterol 77.8 2 11353609 (1), 19234875 (1)
    sterol 54.5 2 12667960 (1)
    iron 24.8 2 8663358 (1)

    Search CenterWatch for drugs/clinical trials and news about MSMO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSMO1 gene (2 alternative transcripts): 
    NM_001017369.2  NM_006745.4  

    Unigene Cluster for MSMO1:

    Methylsterol monooxygenase 1
    Hs.105269  [show with all ESTs]
    Unigene Representative Sequence: NM_006745
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261507(uc003ire.3 uc003irf.3) ENST00000507013 ENST00000393766
    ENST00000504317(uc010irb.3) ENST00000505270
    miRNA
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    Additional mRNA sequence: 

    AK292418.1 AK295432.1 AK309206.1 BC010653.1 BC107879.1 U60205.1 U93162.1 

    17 DOTS entries:

    DT.92448810  DT.101959545  DT.100821460  DT.92448812  DT.95092853  DT.40108055  DT.92448815  DT.100024145 
    DT.100663455  DT.100821470  DT.121217562  DT.95207883  DT.97840208  DT.99954614  DT.100821461  DT.121217561 
    DT.92448811 

    24/293 AceView cDNA sequences (see all 293):

    AA460322 BP362198 CB068570 CA444099 BX398595 BX338516 AA912355 AA658031 
    CA390422 H81691 AA314583 AL601281 AW514688 BQ024923 AA460384 CB051149 
    CN478723 AA992847 BG695880 BM888342 BG167714 R01879 AV703534 AI918416 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MSMO1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                    -     -     -                       -     -                                 
    SP2:                    -     -     -     -                 -     -                                 
    SP3:                                -                       -     -                                 
    SP4:                    -     -     -                                                               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MSMO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSMO1 expression in normal human tissues (normalized intensities)      MSMO1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTGAACCT
    MSMO1 Expression
    About this image


    MSMO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Retina

    See MSMO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSMO1

    SOURCE GeneReport for Unigene cluster: Hs.105269
        SABiosciences Custom PCR Arrays for MSMO1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MSMO1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sc4mol1 , 5 sterol-C4-methyl oxidase-like1, 5 82.94(n)1
    89.08(a)1
      8 (32.30 cM)5
    662341  NM_025436.21  NP_079712.11 
     647181395 
    chicken
    (Gallus gallus)
    Aves SC4MOL1 sterol-C4-methyl oxidase-like 76.89(n)
    83.97(a)
      422423  NM_001006438.1  NP_001006438.1 
    lizard
    (Anolis carolinensis)
    Reptilia MSMO16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343317.1(77360-92970)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb59g062 Danio rerio mRNA similar to sterol-C4-methyl oxidase-like more 75.27(n)    BC050163.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERG25(YGR060W)4
    ERG251
    C-4 methyl sterol oxidase, catalyzes the first of three more4
    Erg25p1
    49.58(n)1
    39.35(a)1
      7(610564-611493)4
    8529511, 4  NP_011574.31  NP_011574.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SMO2-21 sterol 4-alpha-methyl-oxidase 2-2 51.03(n)
    40.74(a)
      817488  NM_179802.2  NP_850133.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g07076001 hypothetical protein 48.76(n)
    40.91(a)
      4351226  NM_001075089.1  NP_001068557.1 


    ENSEMBL Gene Tree for MSMO1 (if available)
    TreeFam Gene Tree for MSMO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSMO1 gene
    CH25H2  FAXDC22  

    MSMO1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MSMO1
    PGOHUM00000246039 PGOHUM00000250068


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/436 SNPs in MSMO1 are shown (see all 436)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151588221,2
    C,F--166246866(+) GGTGGT/CGTGCC 2 -- us2k11Minor allele frequency- C:0.06NA 120
    rs15502681,2
    H--166246890(+) caggaC/Acaaca 2 -- us2k1 tfbs34Minor allele frequency- A:0.00NS EA 400
    rs1431721411,2
    --166246926(+) ACACTA/GAGACA 2 -- us2k10--------
    rs1925494021,2
    --166246936(+) AGCAGC/GGTTTG 2 -- us2k10--------
    rs1466657131,2
    --166246988(+) GATGGA/GAGGAA 2 -- us2k10--------
    rs1856038501,2
    --166247016(+) TCTGAA/GGAGTT 2 -- us2k10--------
    rs729977311,2
    C,F--166247023(+) AGTTCT/CGTGCT 2 -- us2k13Minor allele frequency- C:0.08WA 122
    rs76980561,2
    C,F,A,H--166247185(+) cagtaC/Tgaagg 2 -- us2k127Minor allele frequency- T:0.35NS EA NA WA CSA 2762
    rs1392451221,2
    --166247281(+) CTTGTA/TACAGA 2 -- us2k10--------
    rs76981101,2
    C,F,H--166247317(+) caaacA/Tattat 2 -- us2k16Minor allele frequency- T:0.00NS EA CSA WA 506

    HapMap Linkage Disequilibrium report for MSMO1 (166248775 - 166264312 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MSMO1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv289926CNV Loss16902084


    Human Gene Mutation Database (HGMD): MSMO1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MSMO1
    DNA2.0 Custom Variant and Variant Library Synthesis for MSMO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607545    OMIM disorders: --

    3 diseases for MSMO1:    About MalaCards
    microcephaly    dermatitis    insulin resistance


    MSMO1 for disorders           About GeneDecksing


    Export disorders for MSMO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSMO1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with MSMO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. (PubMed id 8663358)1, 2, 3, 9 Li L. and Kaplan J. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Genome-wide association study identifies novel loci as sociation with fasting insulin and insulin resistance in African Americans. (PubMed id 22791750)1 Chen G....Rotimi C. (2012)
    7. Identification of VKORC1 interaction partners by spli t-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental d elay. (PubMed id 21285510)1 He M....Vockley J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6307 HGNC: 10545 AceView: SC4MOL Ensembl:ENSG00000052802 euGenes: HUgn6307
    ECgene: MSMO1 Kegg: 6307 H-InvDB: MSMO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSMO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSMO1 gene:
    Search GeneIP for patents involving MSMO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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