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MSMB Gene

protein-coding   GIFtS: 54
GCID: GC10P051549

Microseminoprotein, Beta-

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microseminoprotein, Beta-1 2     MSP2
Prostate Secreted Seminal Plasma Protein2 3     MSPB2
Prostate Secretory Protein Of 94 Amino Acids2 3     PRPS2
Seminal Plasma Beta-Inhibin2 3     PSP2
IGBF2 3     PSP572
PN442 3     beta-microseminoprotein2
PSP-942 3     Immunoglobulin Binding Factor2
PSP942 3     PRSP3
HPC132 5     Immunoglobulin-Binding Factor3

External Ids:    HGNC: 73721   Entrez Gene: 44772   Ensembl: ENSG000001382947   OMIM: 1571455   UniProtKB: P081183   

Export aliases for MSMB gene to outside databases

Previous GC identifers: GC10P050393 GC10P051441 GC10P050894 GC10P051219 GC10P045657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSMB Gene:
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the
epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like
activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive
tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively
spliced transcript variants encoding different isoforms are described for this gene. The use of alternate
polyadenylation sites has been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MSMB Gene:
MSMB (microseminoprotein, beta-) is a protein-coding gene. Diseases associated with MSMB include prostate cancer, hereditary, 13, and familial creutzfeldt-jakob disease.

Gene Wiki entry for MSMB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSMB gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   AP-1   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSMB promoter sequence
   Search Chromatin IP Primers for MSMB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.2

MSMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSMB gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P051549:  view genomic region     (about GC identifiers)

Start:
51,549,498 bp from pter      End:
51,562,517 bp from pter
Size:
13,020 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MSMB_HUMAN, P08118 (See protein sequence)
Recommended Name: Beta-microseminoprotein precursor  
Size: 114 amino acids; 12865 Da
Subunit: Homodimer; Interacts with PI16
Miscellaneous: Specific receptors for this protein are found on spermatozoa and in the prostate
Caution: Was originally thought to inhibit the secretion of FSH by pituitary cells
2 PDB 3D structures from and Proteopedia for MSMB:
2IZ3 (3D)        3IX0 (3D)    
Secondary accessions: B1API6 P11999 Q13125 Q6IAY9 Q9UC59
Alternative splicing: 2 isoforms:  P08118-1   P08118-2   

Explore the universe of human proteins at neXtProt for MSMB: NX_P08118

Explore proteomics data for MSMB at MOPED


See MSMB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_002434.1  NP_619540.1  

ENSEMBL proteins: 
 ENSP00000351363   ENSP00000298239  

MSMB Human Recombinant Protein Products:

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R&D Systems Recombinant & Natural Proteins for MSMB (PSP94/MSMB)
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OriGene Purified Protein for MSMB
OriGene Protein Over-expression Lysate for MSMB
OriGene MassSpec for MSMB
OriGene Custom Protein Services for MSMB
GenScript Custom Purified and Recombinant Proteins Services for MSMB
Novus Biologicals MSMB Protein
Novus Biologicals MSMB Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for MSMB
Browse Proteins at Cloud-Clone Corp.

MSMB Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of MSMB
R&D Systems Antibodies for MSMB (PSP94/MSMB)
OriGene Antibodies for MSMB
OriGene Custom Antibody Services for MSMB
Novus Biologicals MSMB Antibodies
Abcam antibodies for MSMB
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for MSMB
LSBio Antibodies in human, mouse, rat for MSMB

MSMB Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for MSMB
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for MSMB
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008735 PSP94

Graphical View of Domain Structure for InterPro Entry P08118

ProtoNet protein and cluster: P08118

1 Blocks protein domain: IPB008735 Beta-microseminoprotein

UniProtKB/Swiss-Prot: MSMB_HUMAN, P08118
Similarity: Belongs to the beta-microseminoprotein family


MSMB for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for MSMB:
microseminoprotein beta,14kDa,synthesized by prostate epithelial cells,secreted in to the seminal fluid

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
MSMB for ontologies           About GeneDecksing


Phenotypes:
     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Msmb):
 endocrine/exocrine gland  immune system  reproductive system  tumorigenesis 

MSMB for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSMB
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSMB

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSMB
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSMB

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat MSMB using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate MSMB
SwitchGear 3'UTR luciferase reporter plasmidMSMB 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MSMB
Predesigned siRNA for gene silencing in human, mouse, rat MSMB

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MSMB

Clone
Products:
     
OriGene clones in human, mouse for MSMB (see all 11)
OriGene ORF clones in mouse, rat for MSMB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): MSMB (NM_002443)
Sino Biological Human cDNA Clone for MSMB
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSMB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSMB

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for MSMB
Browse ESI BIO Cell Lines and PureStem Progenitors for MSMB 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSMB


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MSMB_HUMAN, P08118: Secreted. Note=Sperm surface
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus4
cytoskeleton1
endoplasmic reticulum1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space TAS7566962
GO:0005634nucleus TAS7566962

MSMB for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSMB
Interactions:

    GeneGlobe Interaction Network for MSMB

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

MSMB for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MSMB

9 Novoseek inferred chemical compound relationships for MSMB gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pck-3145 87.3 2 16331603 (1), 16197609 (1)
guanidine hydrochloride 17.3 2 9109822 (2)
fructose 6.96 1 9629442 (1)
hydroxyapatite 6.41 2 7983258 (1), 1347286 (1)
cysteine 0.751 5 20184897 (2), 17493883 (1), 10639193 (1)
steroid 0 1 10412042 (1)
calcium 0 3 11312269 (2), 16495573 (1)
tyrosine 0 1 10049818 (1)
testosterone 0 17 11025776 (5), 11316782 (5), 1544701 (2)



MSMB for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MSMB gene (2 alternative transcripts): 
NM_002443.3  NM_138634.2  

Unigene Cluster for MSMB:

Microseminoprotein, beta-
Hs.255462  [show with all ESTs]
Unigene Representative Sequence: BF965172
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000358559(uc001jiq.3 uc001jir.3) ENST00000487536 ENST00000474170
ENST00000478719 ENST00000466268 ENST00000298239
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MSMB using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate MSMB
SwitchGear 3'UTR luciferase reporter plasmidMSMB 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MSMB
Predesigned siRNA for gene silencing in human, mouse, rat MSMB
Clone
Products:
     
OriGene clones in human, mouse for MSMB (see all 11)
OriGene ORF clones in mouse, rat for MSMB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): MSMB (NM_002443)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSMB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSMB
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MSMB
OriGene qSTAR qPCR primer pairs in human, mouse for MSMB
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSMB
  QuantiTect SYBR Green Assays in human, mouse, rat MSMB
  QuantiFast Probe-based Assays in human, mouse, rat MSMB

Additional mRNA sequence: 

AK312108.1 BC005257.1 BT006816.1 CR457015.1 M15885.1 S67815.1 U22178.1 U78976.1 

19 DOTS entries:

DT.95376322  DT.91768534  DT.100037349  DT.95376324  DT.91768532  DT.121281503  DT.121281879  DT.121281564 
DT.95376325  DT.121281781  DT.95376316  DT.87001710  DT.75118122  DT.121281877  DT.432060  DT.95376321 
DT.121281754  DT.92395591  DT.96086444 

Selected AceView cDNA sequences (see all 562):

AA369901 AA588630 BF445307 AA588853 BM768859 M15885 AI814096 CB049601 
AI817297 BE672898 AA507128 BM855253 CA313444 BF965280 AA570614 AA541642 
BX109629 BX641403 BM854039 AA635542 AA603052 AI682557 AI658868 AA662301 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MSMB (see all 7)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1:              -                 -     -                     
SP2:                                                            
SP3:                                -     -                     
SP4:              -                                             
SP5:              -           -     -     -                     


ECgene alternative splicing isoforms for MSMB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MSMB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTATCAGTA
MSMB Expression
About this image

MSMB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MSMB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.255462

UniProtKB/Swiss-Prot: MSMB_HUMAN, P08118
Tissue specificity: Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas,
esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in
lung and breast, whereas PSP57 is found in kidney and bladder

    Custom PCR Arrays for MSMB
Primer
Products:
OriGene qPCR primer pairs and template standards for MSMB
OriGene qSTAR qPCR primer pairs in human, mouse for MSMB
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSMB
QuantiTect SYBR Green Assays in human, mouse, rat MSMB
QuantiFast Probe-based Assays in human, mouse, rat MSMB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSMB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MSMB gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Msmb1 , 5 beta-microseminoprotein1, 5 58.11(n)1
43.36(a)1
  14 (19.40 cM)5
176951  NM_020597.31  NP_065622.11 
 321420265 
chicken
(Gallus gallus)
Aves MSMB6
microseminoprotein, beta-
40(a)
1 ↔ 1
6(17368972-17383658)


ENSEMBL Gene Tree for MSMB (if available)
TreeFam Gene Tree for MSMB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MSMB (see all 382)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1139126901,2
C,F--51551217(+) ATACAC/ACTTTT 2 -- int13Minor allele frequency- A:0.40WA CSA 5
rs560611751,2
C,F--51551246(+) TTTTT-/TCTGAG 4 -- int11Minor allele frequency- T:0.02MN 98
rs575927851,2
C--51551900(+) GCGGGG/-CGGAT 2 -- int11Minor allele frequency- -:0.00CSA 2
rs1131112091,2
C,F--51551900(+) CGAGG-/GGGCGG 2 -- int11Minor allele frequency- G:0.14MN 140
rs757986731,2
C--51560175(+) GTCCCC/TCAAAC 2 -- int10--------
rs122549691,2
H--51560191(+) gtaatC/Ttcaag 2 -- int14Minor allele frequency- T:0.00NS EA 408
rs1883615691,2
C--51560196(+) CTCAAA/GTCTAC 2 -- int10--------
rs70709651,2
C,F,A,H--51560207(+) TTTCTG/ATCTCT 2 -- int110Minor allele frequency- A:0.33NA WA MN CSA EA 500
rs794805761,2
C--51560213(+) TCTCTA/GTGAAT 2 -- int12Minor allele frequency- G:0.02MN WA 258
rs733181971,2
C,F--51560373(+) TGGCAT/CGGTCA 2 -- int16Minor allele frequency- C:0.09WA MN CSA NA 383

HapMap Linkage Disequilibrium report for MSMB (51549498 - 51562517 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MSMB (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
nsv6643CNV Insertion18451855
nsv508583CNV Loss20534489
nsv895383CNV Loss21882294
nsv895386CNV Gain21882294
nsv521269CNV Gain19592680
nsv895385CNV Gain21882294
nsv470936CNV Gain18288195
dgv702n71CNV Gain21882294
nsv895388CNV Gain21882294
nsv467192CNV Gain19166990

Human Gene Mutation Database (HGMD): MSMB
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MSMB
DNA2.0 Custom Variant and Variant Library Synthesis for MSMB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 157145   
OMIM disorders: 611928  
UniProtKB/Swiss-Prot: MSMB_HUMAN, P08118
  • Prostate cancer, hereditary, 13 (HPC13) [MIM:611928]: A condition associated with familial predisposition
    to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic
    ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include
    small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell
    carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and
    neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • Selected diseases for MSMB (see all 27):    
    About MalaCards
    prostate cancer, hereditary, 13    familial creutzfeldt-jakob disease    arts syndrome    prostatitis
    prostate adenocarcinoma    bovine spongiform encephalopathy    prostate cancer, progression and metastasis of    prion disease
    scrapie    spermatogenic failure    prostate cancer    adenoiditis
    neuroendocrine carcinoma    adenoid cystic carcinoma    small cell carcinoma    transitional cell carcinoma
    infertility    basal cell carcinoma    adenocarcinoma    rheumatoid arthritis

    3 diseases from the University of Copenhagen DISEASES database for MSMB:
    Scrapie     Prostate cancer     Bovine spongiform encephalopathy

    MSMB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MSMB gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prion diseases 66.7 3 10953401 (1), 8643624 (1)
    familial creutzfeldt-jakob disease 64.5 2 8643624 (1)
    prostate cancer 62.7 53 10581002 (4), 9973097 (4), 17237810 (4), 7509484 (3) (see all 28)
    prostatic adenocarcinoma 58.8 4 15674347 (1), 16809150 (1), 9817377 (1), 9537594 (1)
    prostatic intraepithelial neoplasia 56.9 1 16278416 (1)
    prostate carcinoma 33.9 5 7688168 (3), 10477906 (1), 9136076 (1)
    creutzfeldt-jakob disease 30.4 1 18160847 (1)
    benign prostatic hyperplasia 24 4 7688168 (2), 7509484 (1), 8939292 (1)
    premalignant 9.66 1 10477906 (1)
    tumors 7.79 34 7509484 (3), 11025776 (3), 17237810 (3), 15727931 (2) (see all 16)

    Genetic Association Database (GAD): MSMB
    Human Genome Epidemiology (HuGE) Navigator: MSMB (29 documents)

    Export disorders for MSMB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSMB gene, integrated from 10 sources (see all 179):
    (articles sorted by number of sources associating them with MSMB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple loci identified in a genome-wide association study of prostate cancer. (PubMed id 18264096)1, 2, 4 Thomas G.... Chanock S.J. (Nat. Genet. 2008)
    2. Alternative splicing of PSP94 (prostatic secretory protein of 94 amino acids) mRNA in prostate tissue. (PubMed id 7566962)1, 2, 9 Xuan J.W....Clarke M.W. (Oncogene 1995)
    3. Crystal structure of prostate secretory protein PSP94 shows an edge- to-edge association of two monomers to form a homodimer. (PubMed id 20184897)1, 2, 9 Kumar A.... Kumar M. (J. Mol. Biol. 2010)
    4. Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. (PubMed id 19383797)1, 4, 9 Lou H....Chanock S.J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Solution structures of human and porcine beta-microseminoprotein. (PubMed id 16930619)1, 2, 9 Ghasriani H.... Drakenberg T. (J. Mol. Biol. 2006)
    6. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PubMed id 15344909)1, 2, 9 Reeves J.R.... Tanner J.E. (Biochem. J. 2005)
    7. Structural identity of immunoglobulin binding factor and prostatic secretory protein of human seminal plasma. (PubMed id 1930232)1, 2, 9 Liang Z.G.... Koide S.S. (Biochem. Biophys. Res. Commun. 1991)
    8. Cloning and nucleotide sequence analysis of the human beta- microseminoprotein gene. (PubMed id 2322265)1, 2, 9 Green C.B.... Kwok S.C.M. (Biochem. Biophys. Res. Commun. 1990)
    9. Decreased expression of prostatic secretory protein PSP94 in prostate cancer. (PubMed id 7506990)1, 2, 9 Liu A.Y.... Vessella R.L. (Cancer Lett. 1993)
    10. Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. (PubMed id 1783399)1, 3, 9 UlvsbAock M....Lundwall A. (Genomics 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4477 HGNC: 7372 AceView: MSMB Ensembl:ENSG00000138294 euGenes: HUgn4477
    ECgene: MSMB H-InvDB: MSMB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSMB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSMB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSMB gene:
    Search GeneIP for patents involving MSMB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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