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Aliases for MSMB Gene

Aliases for MSMB Gene

  • Microseminoprotein, Beta- 2 3
  • Prostate Secretory Protein Of 94 Amino Acids 3 4
  • Prostate Secreted Seminal Plasma Protein 3 4
  • Seminal Plasma Beta-Inhibin 3 4
  • PSP-94 3 4
  • PSP94 3 4
  • IGBF 3 4
  • PN44 3 4
  • Immunoglobulin Binding Factor 3
  • Immunoglobulin-Binding Factor 4
  • HPC13 3
  • PSP57 3
  • Prsp 4
  • MSPB 3
  • PRPS 3
  • PSP 3
  • MSP 3

External Ids for MSMB Gene

Previous GeneCards Identifiers for MSMB Gene

  • GC10P050393
  • GC10P051441
  • GC10P050894
  • GC10P051219
  • GC10P051549
  • GC10P045657

Summaries for MSMB Gene

Entrez Gene Summary for MSMB Gene

  • The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSMB Gene

MSMB (Microseminoprotein, Beta-) is a Protein Coding gene. Diseases associated with MSMB include prostate cancer, hereditary, 13 and familial creutzfeldt-jakob disease.

Gene Wiki entry for MSMB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSMB Gene

Genomics for MSMB Gene

Regulatory Elements for MSMB Gene

Genomic Location for MSMB Gene

Chromosome:
10
Start:
46,033,305 bp from pter
End:
46,046,269 bp from pter
Size:
12,965 bases
Orientation:
Minus strand

Genomic View for MSMB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSMB Gene

Proteins for MSMB Gene

  • Protein details for MSMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08118-MSMB_HUMAN
    Recommended name:
    Beta-microseminoprotein
    Protein Accession:
    P08118
    Secondary Accessions:
    • B1API6
    • P11999
    • Q13125
    • Q6IAY9
    • Q9UC59

    Protein attributes for MSMB Gene

    Size:
    114 amino acids
    Molecular mass:
    12865 Da
    Quaternary structure:
    • Homodimer; Interacts with PI16.
    Miscellaneous:
    • Specific receptors for this protein are found on spermatozoa and in the prostate

    Three dimensional structures from OCA and Proteopedia for MSMB Gene

    Alternative splice isoforms for MSMB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSMB Gene

Proteomics data for MSMB Gene at MOPED

Post-translational modifications for MSMB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSMB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MSMB Gene

Domains & Families for MSMB Gene

Protein Domains for MSMB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MSMB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08118

UniProtKB/Swiss-Prot:

MSMB_HUMAN :
  • Belongs to the beta-microseminoprotein family.
Family:
  • Belongs to the beta-microseminoprotein family.
genes like me logo Genes that share domains with MSMB: view

No data available for Gene Families for MSMB Gene

Function for MSMB Gene

Molecular function for MSMB Gene

GENATLAS Biochemistry:
microseminoprotein beta,14kDa,synthesized by prostate epithelial cells,secreted in to the seminal fluid

Gene Ontology (GO) - Molecular Function for MSMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MSMB: view
genes like me logo Genes that share phenotypes with MSMB: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSMB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MSMB Gene

Localization for MSMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSMB Gene

Secreted. Note=Sperm surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSMB Gene COMPARTMENTS Subcellular localization image for MSMB gene
Compartment Confidence
chloroplast 1

Gene Ontology (GO) - Cellular Components for MSMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 7566962
GO:0005634 nucleus TAS 7566962
genes like me logo Genes that share ontologies with MSMB: view

Pathways & Interactions for MSMB Gene

SuperPathways for MSMB Gene

No Data Available

Interacting Proteins for MSMB Gene

Selected Interacting proteins: P08118-MSMB_HUMAN for MSMB Gene via UniProtKB

Symbol External ID(s) Details
SGTA

Gene Ontology (GO) - Biological Process for MSMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MSMB: view

No data available for Pathways by source and SIGNOR curated interactions for MSMB Gene

Drugs & Compounds for MSMB Gene

(5) Drugs for MSMB Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
fructose Experimental Pharma 0
Calcium Nutra 0
cysteine Nutra 143
tyrosine Nutra 547

(4) Additional Compounds for MSMB Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Guanidine hydrochloride
hydroxyapatite
pck-3145
Steroid
genes like me logo Genes that share compounds with MSMB: view

Transcripts for MSMB Gene

mRNA/cDNA for MSMB Gene

Unigene Clusters for MSMB Gene

Microseminoprotein, beta-:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSMB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSMB Gene

No ASD Table

Relevant External Links for MSMB Gene

GeneLoc Exon Structure for
MSMB
ECgene alternative splicing isoforms for
MSMB

Expression for MSMB Gene

mRNA expression in normal human tissues for MSMB Gene

mRNA differential expression in normal tissues according to GTEx for MSMB Gene

This gene is overexpressed in Prostate (x50.7).

Protein differential expression in normal tissues from HIPED for MSMB Gene

This gene is overexpressed in Urine (54.8) and Prostate (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MSMB Gene



SOURCE GeneReport for Unigene cluster for MSMB Gene Hs.255462

mRNA Expression by UniProt/SwissProt for MSMB Gene

P08118-MSMB_HUMAN
Tissue specificity: Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.
genes like me logo Genes that share expression patterns with MSMB: view

Protein tissue co-expression partners for MSMB Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MSMB Gene

Orthologs for MSMB Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MSMB Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Msmb 35
  • 58.11 (n)
  • 43.36 (a)
Msmb 16
chimpanzee
(Pan troglodytes)
Mammalia MSMB 35
  • 99.12 (n)
  • 98.25 (a)
rat
(Rattus norvegicus)
Mammalia Msmb 35
  • 62.24 (n)
  • 46.02 (a)
Species with no ortholog for MSMB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MSMB Gene

ENSEMBL:
Gene Tree for MSMB (if available)
TreeFam:
Gene Tree for MSMB (if available)

Paralogs for MSMB Gene

No data available for Paralogs for MSMB Gene

Variants for MSMB Gene

Sequence variations from dbSNP and Humsavar for MSMB Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2072701 -- 46,039,373(-) TACCC(A/G)CAGGC intron-variant
rs2075894 -- 46,039,711(-) AAAGA(C/T)GGGGC intron-variant
rs2075895 -- 46,039,372(-) ACCCA(C/T)AGGCT intron-variant
rs4134357 -- 46,041,498(+) ATATA(A/T)GAATA intron-variant
rs4351762 -- 46,045,645(-) CAGGT(C/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSMB Gene

Variant ID Type Subtype PubMed ID
dgv273e1 CNV Complex 17122850
nsv428232 CNV Gain+Loss 18775914
dgv274e1 CNV Complex 17122850
nsv895383 CNV Loss 21882294
nsv508583 CNV Loss 20534489
dgv275e1 CNV Complex 17122850
nsv510992 CNV Complex 20534489
dgv702n71 CNV Gain 21882294
nsv895385 CNV Gain 21882294
nsv895386 CNV Gain 21882294
nsv467192 CNV Gain 19166990
nsv470936 CNV Gain 18288195
nsv521269 CNV Gain 19592680
nsv6643 CNV Insertion 18451855
nsv895388 CNV Gain 21882294

Variation tolerance for MSMB Gene

Residual Variation Intolerance Score: 56.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSMB Gene

HapMap Linkage Disequilibrium report
MSMB
Human Gene Mutation Database (HGMD)
MSMB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSMB Gene

Disorders for MSMB Gene

MalaCards: The human disease database

(6) MalaCards diseases for MSMB Gene - From: OMIM, ClinVar, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer, hereditary, 13
  • familial prostate cancer 13
familial creutzfeldt-jakob disease
  • fcjd
prostate cancer
  • prostate cancer, hereditary, 5
male reproductive organ cancer
  • malignant neoplasm of male genital organ, unspecified
prostate adenocarcinoma
  • adenocarcinoma of prostate
- elite association
Search MSMB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MSMB_HUMAN
  • Prostate cancer, hereditary, 13 (HPC13) [MIM:611928]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for MSMB

Genetic Association Database (GAD)
MSMB
Human Genome Epidemiology (HuGE) Navigator
MSMB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSMB
genes like me logo Genes that share disorders with MSMB: view

No data available for Genatlas for MSMB Gene

Publications for MSMB Gene

  1. Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. (PMID: 1783399) UlvsbAock M. … Lundwall A. (Genomics 1991) 2 23 67
  2. Mutation analysis of the MSMB gene in familial prostate cancer. (PMID: 19997100) Kote-Jarai Z. … Eeles R. (Br. J. Cancer 2010) 23 67
  3. Crystal structure of prostate secretory protein PSP94 shows an edge- to-edge association of two monomers to form a homodimer. (PMID: 20184897) Kumar A. … Kumar M. (J. Mol. Biol. 2010) 23 67
  4. Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. (PMID: 19927125) Lee S. … Yee V.C. (EMBO J. 2010) 23 67
  5. Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. (PMID: 19383797) Lou H. … Chanock S.J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67

Products for MSMB Gene

Sources for MSMB Gene

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