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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSMB Gene

protein-coding   GIFtS: 55
GCID: GC10P051549

microseminoprotein, beta-
 Explore 21 diseases affiliated with
MSMB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MSMB    

Aliases
for MSMB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microseminoprotein, Beta-1 2     PSP571 2
IGBF1 2 3     Prostate Secreted Seminal Plasma Protein2 3
PN441 2 3     Prostate Secretory Protein Of 94 Amino Acids2 3
PSP-941 2 3     Seminal Plasma Beta-Inhibin2 3
PSP941 2 3     HPC132 5
MSP1 2     Beta-Microseminoprotein1
MSPB1 2     Immunoglobulin Binding Factor2
PRPS1 2     PRSP3
PSP1 2     Immunoglobulin-Binding Factor3

External Ids:    HGNC: 73721   Entrez Gene: 44772   Ensembl: ENSG000001382947   OMIM: 1571455   UniProtKB: P081183   

Export aliases for MSMB gene to outside databases

Previous GC identifers: GC10P050393 GC10P051441 GC10P050894 GC10P051219 GC10P045657


Summaries
for MSMB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MSMB:
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the
epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity.
It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The
expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript
variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been
found for this gene. (provided by RefSeq, Jul 2008)

Gene Wiki entry for MSMB


Genomic Views
for MSMB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSMB gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   AP-1   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MSMB promoter sequence
   Search SABiosciences Chromatin IP Primers for MSMB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.23   HGNC cytogenetic band: 10q11.2

MSMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSMB gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P051549:  view genomic region     (about GC identifiers)

Start:
 51,549,498 bp from pter      End:
 51,562,595 bp from pter
Size:
 13,098 bases      Orientation:
 plus strand

Proteins
for MSMB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MSMB_HUMAN, P08118 (See protein sequence)
Recommended Name: Beta-microseminoprotein precursor  
Size: 114 amino acids; 12865 Da
Subunit: Homodimer; Interacts with PI16
Subcellular location: Secreted. Note=Sperm surface
Miscellaneous: Specific receptors for this protein are found on spermatozoa and in the prostate
Caution: Was originally thought to inhibit the secretion of FSH by pituitary cells
2 PDB 3D structures from and Proteopedia for MSMB:
2IZ3 (3D)        3IX0 (3D)    
Secondary accessions: B1API6 P11999 Q13125 Q6IAY9 Q9UC59
Alternative splicing: 2 isoforms:  P08118-1   P08118-2   

Explore the universe of human proteins at neXtProt for MSMB: NX_P08118

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08118

    • MSMB Protein expression data from MOPED and PaxDb:    About this image 
    MSMB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002434.1  NP_619540.1  

    ENSEMBL proteins: 
     ENSP00000351363   ENSP00000298239  

    Human Recombinant Protein Products for MSMB: 
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    R&D Systems Recombinant & Natural Proteins for MSMB (PSP94/MSMB)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MSMB
    OriGene Protein Over-expression Lysate: MSMB
    OriGene Custom Protein Services for MSMB 
    GenScript Custom Purified and Recombinant Proteins Services for MSMB
    Novus Biologicals MSMB Protein
    Novus Biologicals MSMB Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MSMB
    Uscn Proteins for MSMB

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7566962
    GO:0005634nucleus TAS7566962

    MSMB for ontologies           About GeneDecksing



    MSMB Antibody Products: 
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    Abcam antibodies for MSMB 
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    Assay Products for MSMB: 
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    Uscn ELISAs and CLIAs for MSMB

    Protein Domains /
    Families
    for MSMB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MSMB for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008735 PSP94

    Graphical View of Domain Structure for InterPro Entry P08118

    ProtoNet protein and cluster: P08118

    1 Blocks protein family: IPB008735 Beta-microseminoprotein

    UniProtKB/Swiss-Prot: MSMB_HUMAN, P08118
    Similarity: Belongs to the beta-microseminoprotein family


    Function
    for MSMB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:
         Genatlas biochemistry entry for MSMB:
    microseminoprotein beta,14kDa,synthesized by prostate epithelial cells,secreted in to the seminal fluid

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    MSMB for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Msmb):
     endocrine/exocrine gland  immune system  reproductive system  tumorigenesis 

    MSMB for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MSMB 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): MSMB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSMB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MSMB
    SwitchGear 3'UTR luciferase reporter plasmid: MSMB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSMB (see all 7)
    OriGene shRNA RFP: MSMB
    OriGene siRNA: MSMB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSMB
    Sirion Biotech Custom design and validation of potent shRNA sequences against MSMB 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MSMB
    Sirion Biotech Customized adenovirus for overexpression of MSMB 
    Sirion Biotech Customized adenovirus for potent knockdown of MSMB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSMB (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSMB (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MSMB (NM_002443)
    Sino Biological Human cDNA Clone for MSMB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSMB 

    Cell Line
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    Search LifeMap BioReagents cell lines for MSMB
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    Sirion Biotech Customized stable overexpressing cell line services for MSMB
    Sirion Biotech Customized inducible overexpressing cell line services for MSMB

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MSMB


    Pathways & Interactions
    for MSMB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MSMB

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    MSMB for ontologies           About GeneDecksing



    Drugs & Compounds
    for MSMB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MSMB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSMB
    9 Novoseek chemical compound relationships for MSMB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pck-3145 87.3 2 16331603 (1), 16197609 (1)
    guanidine hydrochloride 17.3 2 9109822 (2)
    fructose 6.96 1 9629442 (1)
    hydroxyapatite 6.41 2 7983258 (1), 1347286 (1)
    cysteine 0.751 5 20184897 (2), 17493883 (1), 10639193 (1)
    steroid 0 1 10412042 (1)
    calcium 0 3 11312269 (2), 16495573 (1)
    tyrosine 0 1 10049818 (1)
    testosterone 0 17 11025776 (5), 11316782 (5), 1544701 (2)

    Search CenterWatch for drugs/clinical trials and news about MSMB 

    Transcripts
    for MSMB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MSMB gene (2 alternative transcripts): 
    NM_002443.3  NM_138634.2  

    Unigene Cluster for MSMB:

    Microseminoprotein, beta-
    Hs.255462  [show with all ESTs]
    Unigene Representative Sequence: BF965172
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358559(uc001jiq.3 uc001jir.3) ENST00000298239 ENST00000487536
    ENST00000478719 ENST00000466268 ENST00000474170

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MSMB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSMB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MSMB
    SwitchGear 3'UTR luciferase reporter plasmid: MSMB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSMB (see all 7)
    OriGene shRNA RFP: MSMB
    OriGene siRNA: MSMB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSMB
    Sirion Biotech Custom design and validation of potent shRNA sequences against MSMB 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSMB (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSMB (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MSMB (NM_002443)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSMB 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSMB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSMB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSMB

    Additional cDNA sequence: 

    AK312108.1 BC005257.1 BT006816.1 CR457015.1 M15885.1 S67815.1 U22178.1 U78976.1 

    19 DOTS entries:

    DT.95376322  DT.91768534  DT.100037349  DT.95376324  DT.91768532  DT.121281503  DT.121281879  DT.121281564 
    DT.95376325  DT.121281781  DT.95376316  DT.87001710  DT.75118122  DT.121281877  DT.432060  DT.95376321 
    DT.121281754  DT.92395591  DT.96086444 

    24/562 AceView cDNA sequences (see all 562):

    AA807843 AA662301 BF445307 BM855253 AI682557 AA548400 CB850938 NM_138634 
    CB049601 AI420347 CA313444 AA661727 AI298524 AA662090 BM768858 AA687632 
    AI299122 M15885 AA588630 NM_002443 AI829244 BM768648 BM768852 BE672898 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MSMB (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:              -                 -     -                     
    SP2:                                                            
    SP3:                                -     -                     
    SP4:              -                                             
    SP5:              -           -     -     -                     


    ECgene alternative splicing isoforms for MSMB

    Expression
    for MSMB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSMB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTATCAGTA
    MSMB Expression
    About this image

    MSMB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MSMB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSMB

    SOURCE GeneReport for Unigene cluster: Hs.255462

    UniProtKB/Swiss-Prot: MSMB_HUMAN, P08118
    Tissue specificity: Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas,
    esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and
    breast, whereas PSP57 is found in kidney and bladder

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    In Situ
    Assay Products:     
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    Orthologs
    for MSMB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MSMB gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Msmb1 , 5 beta-microseminoprotein1, 5 58.26(n)1
    44.14(a)1    		   14 (19.40 cM)5
    176951  NM_020597.31  NP_065622.11 
     321420265 
    chicken
    (Gallus gallus)    		 Aves MSMB6
    		 Uncharacterized protein
    		 42(a)
    		 1 ↔ 1
    		 6(18914141-18918102)


    ENSEMBL Gene Tree for MSMB (if available)
    TreeFam Gene Tree for MSMB (if available) 

    Paralogs
    for MSMB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MSMB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/323 NCBI SNPs in MSMB are shown (see all 323)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1457181751,2
    		--51547599(+) AAACAA/GTAGAA 2 -- us2k10--------
    rs1404841971,2
    		--51547858(+) ATTCTA/GCATGA 2 -- us2k10--------
    rs1459124041,2
    		--51548083(+) TGCCCC/TGATTT 2 -- us2k10--------
    rs1466311951,2
    		--51548329(+) ATGAAC/TTCTCA 2 -- us2k10--------
    rs794191261,2
    		F--51548377(+) CTGTAG/CCAAGC 2 -- us2k12Minor allele frequency- C:0.33NA 6
    rs618470701,2
    		C,F--51548455(+) ATTCAT/CTGGTT 2 -- us2k14Minor allele frequency- C:0.05NA MN EA 382
    rs775503481,2
    		C,F--51548609(+) AGAGAG/CAGATG 2 -- us2k12Minor allele frequency- C:0.01MN NA 260
    rs1824209651,2
    		--51548696(+) CAAGCC/TTTCCC 2 -- us2k10--------
    rs733181771,2
    		C--51548768(+) AAGCCT/ACCCAG 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs114108451,2
    		C--51548795(+) GGTGG-/CCAGAG 2 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for MSMB (51549498 - 51562595 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MSMB
         1 CNV: 3800
    Human Gene Mutation Database (HGMD): MSMB

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSMB
    DNA2.0 Custom Variant and Variant Library Synthesis for MSMB

    Disorders / Diseases
    for MSMB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MSMB for disorders           About GeneDecksing

    OMIM gene information: 157145   
    OMIM disorders: 611928  
    UniProtKB/Swiss-Prot: MSMB_HUMAN, P08118
  • Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:611928]. It
    • is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are
    adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer
    that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal
    carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma
    (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma

    20/21 diseases for MSMB (see all 21):    About MalaCards
    prostatitis    familial creutzfeldt-jakob disease    prostate cancer    bovine spongiform encephalopathy
    prostate cancer, hereditary, 13    arts syndrome    prion disease    transitional cell carcinoma
    basal cell carcinoma    neurodegenerative disease    scrapie    prostate adenocarcinoma
    neuroendocrine carcinoma    rheumatoid arthritis    prostate cancer, progression of    carcinoma
    adenocarcinoma    endometrial cancer    arthritis    gastric cancer

    4 diseases from the University of Copenhagen DISEASES database for MSMB:
    Scrapie     Prostate cancer     Bovine spongiform encephalopathy     Arts syndrome

    10/20 Novoseek disease relationships for MSMB gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prion diseases 66.7 3 10953401 (1), 8643624 (1)
    familial creutzfeldt-jakob disease 64.5 2 8643624 (1)
    prostate cancer 62.7 53 10581002 (4), 9973097 (4), 17237810 (4), 7509484 (3) (see all 28)
    prostatic adenocarcinoma 58.8 4 15674347 (1), 16809150 (1), 9817377 (1), 9537594 (1)
    prostatic intraepithelial neoplasia 56.9 1 16278416 (1)
    prostate carcinoma 33.9 5 7688168 (3), 10477906 (1), 9136076 (1)
    creutzfeldt-jakob disease 30.4 1 18160847 (1)
    benign prostatic hyperplasia 24 4 7688168 (2), 7509484 (1), 8939292 (1)
    premalignant 9.66 1 10477906 (1)
    tumors 7.79 34 7509484 (3), 11025776 (3), 17237810 (3), 15727931 (2) (see all 16)

    Human Genome Epidemiology (HuGE) Navigator: MSMB (29 documents)

    Export disorders for MSMB gene to outside databases

    Publications
    for MSMB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSMB gene, integrated from 9 sources (see all 172):
    (articles sorted by number of sources associating them with MSMB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing of PSP94 (prostatic secretory protein of 94 amino acids) mRNA in prostate tissue. (PubMed id 7566962)1, 2, 9 Xuan J.W....Clarke M.W. (1995)
    2. Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer. (PubMed id 20184897)1, 2, 9 Kumar A....Kumar M. (2010)
    3. Solution structures of human and porcine beta-microseminoprotein. (PubMed id 16930619)1, 2, 9 Ghasriani H.... Drakenberg T. (2006)
    4. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PubMed id 15344909)1, 2, 9 Reeves J.R.... Tanner J.E. (2005)
    5. Structural identity of immunoglobulin binding factor and prostatic secretory protein of human seminal plasma. (PubMed id 1930232)1, 2, 9 Liang Z.G.... Koide S.S. (1991)
    6. Cloning and nucleotide sequence analysis of the human beta- microseminoprotein gene. (PubMed id 2322265)1, 2, 9 Green C.B.... Kwok S.C.M. (1990)
    7. Decreased expression of prostatic secretory protein PSP94 in prostate cancer. (PubMed id 7506990)1, 2, 9 Liu A.Y.... Vessella R.L. (1993)
    8. Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates. (PubMed id 1783399)1, 3, 9 Ulvsback M....Lundwall A. (1991)
    9. Multiple loci identified in a genome-wide association study of prostate cancer. (PubMed id 18264096)1, 2 Thomas G....Chanock S.J. (2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for MSMB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MSMB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4477 HGNC: 7372 AceView: MSMB Ensembl:ENSG00000138294 euGenes: HUgn4477
    ECgene: MSMB H-InvDB: MSMB

    Other Databases showing MSMB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MSMB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSMB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSMB Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MSMB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MSMB gene:
    Search GeneIP for patents involving MSMB

    GeneCards and IP:
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