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Aliases for MSLNL Gene

Aliases for MSLNL Gene

  • Mesothelin-Like 2 3
  • Pre-Pro-Megakaryocyte-Potentiating-Factor-Like 3 4
  • C16orf37 3 4
  • MPFL 3 4
  • Chromosome 16 Open Reading Frame 37 2
  • Megakarycyte Potentiating Factor 3
  • MPF-Like 3

External Ids for MSLNL Gene

Previous HGNC Symbols for MSLNL Gene

  • C16orf37

Previous GeneCards Identifiers for MSLNL Gene

  • GC16M000766
  • GC16M000819
  • GC16M000741

Summaries for MSLNL Gene

GeneCards Summary for MSLNL Gene

MSLNL (Mesothelin-Like) is a Pseudogene. Diseases associated with MSLNL include patellofemoral pain syndrome and hemarthrosis. An important paralog of this gene is MSLN.

UniProtKB/Swiss-Prot for MSLNL Gene

  • May play a role in cellular adhesion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSLNL Gene

Genomics for MSLNL Gene

Regulatory Elements for MSLNL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MSLNL Gene

Start:
769,428 bp from pter
End:
783,370 bp from pter
Size:
13,943 bases
Orientation:
Minus strand

Genomic View for MSLNL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSLNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSLNL Gene

Proteins for MSLNL Gene

  • Protein details for MSLNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KJ4-MSLNL_HUMAN
    Recommended name:
    Mesothelin-like protein
    Protein Accession:
    Q96KJ4
    Secondary Accessions:

    Protein attributes for MSLNL Gene

    Size:
    702 amino acids
    Molecular mass:
    74540 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61254.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on gene prediction by similarity with the mouse ortholog.; Evidence={ECO:0000305}; Sequence=EAW85717.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on gene prediction by similarity with the mouse ortholog.; Evidence={ECO:0000305};

neXtProt entry for MSLNL Gene

Proteomics data for MSLNL Gene at MOPED

Post-translational modifications for MSLNL Gene

  • Glycosylation at Asn122, Asn307, and Asn424
  • Modification sites at PhosphoSitePlus

Other Protein References for MSLNL Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MSLNL Gene

Domains for MSLNL Gene

Protein Domains for MSLNL Gene

Suggested Antigen Peptide Sequences for MSLNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KJ4

UniProtKB/Swiss-Prot:

MSLNL_HUMAN :
  • Q96KJ4
Family:
  • Belongs to the mesothelin family.
genes like me logo Genes that share domains with MSLNL: view

No data available for Gene Families for MSLNL Gene

Function for MSLNL Gene

Molecular function for MSLNL Gene

UniProtKB/Swiss-Prot Function: May play a role in cellular adhesion.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MSLNL Gene

Localization for MSLNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSLNL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSLNL Gene COMPARTMENTS Subcellular localization image for MSLNL gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MSLNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MSLNL: view

Pathways for MSLNL Gene

SuperPathways for MSLNL Gene

No Data Available

Interacting Proteins for MSLNL Gene

Gene Ontology (GO) - Biological Process for MSLNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with MSLNL: view

No data available for Pathways by source for MSLNL Gene

Transcripts for MSLNL Gene

mRNA/cDNA for MSLNL Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSLNL

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MSLNL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSLNL Gene

No ASD Table

Relevant External Links for MSLNL Gene

GeneLoc Exon Structure for
MSLNL
ECgene alternative splicing isoforms for
MSLNL

Expression for MSLNL Gene

mRNA expression in normal human tissues for MSLNL Gene

mRNA differential expression in normal tissues according to GTEx for MSLNL Gene

This gene is overexpressed in Brain - Cortex (7.1), Lung (5.0), Fallopian Tube (4.8), Brain - Frontal Cortex (BA9) (4.7), and Brain - Putamen (basal ganglia) (4.0).
genes like me logo Genes that share expressions with MSLNL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MSLNL Gene

Orthologs for MSLNL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSLNL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSLNL 36
  • 59 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSLNL 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSLNL 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mslnl 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSLNL 36
  • 20 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSLNL 36
  • 38 (a)
OneToOne
Species with no ortholog for MSLNL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MSLNL Gene

ENSEMBL:
Gene Tree for MSLNL (if available)
TreeFam:
Gene Tree for MSLNL (if available)

Paralogs for MSLNL Gene

Paralogs for MSLNL Gene

genes like me logo Genes that share paralogs with MSLNL: view

Variants for MSLNL Gene

Sequence variations from dbSNP and Humsavar for MSLNL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_039256 -, -
VAR_039258 -

Structural Variations from Database of Genomic Variants (DGV) for MSLNL Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
nsv1702 CNV Insertion 18451855
dgv2498n71 CNV Loss 21882294
dgv2499n71 CNV Loss 21882294
dgv2500n71 CNV Loss 21882294
nsv457312 CNV Loss 19166990
nsv517488 CNV Loss 19592680
esv2750233 CNV Deletion 23290073
nsv817712 CNV Loss 17921354
esv2659324 CNV Deletion 23128226
nsv904841 CNV Loss 21882294

Relevant External Links for MSLNL Gene

HapMap Linkage Disequilibrium report
MSLNL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSLNL Gene

Disorders for MSLNL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MSLNL Gene including...

Search for MSLNL Gene in MalaCards »

(2) University of Copenhagen DISEASES for MSLNL Gene

genes like me logo Genes that share disorders with MSLNL: view

No data available for UniProtKB/Swiss-Prot for MSLNL Gene

Publications for MSLNL Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  2. Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma. (PMID: 21841505) Hollevoet K. … van Meerbeeck J.P. (J Thorac Oncol 2011) 3
  3. Inactivation of the MSLNL gene encoding mesothelin-like protein during African great ape evolution. (PMID: 22265842) Kim D.W. … Hahn Y. (Gene 2012) 3
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4
  5. Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats. (PMID: 19128473) Sathyanarayana B.K. … Lee B. (BMC Struct. Biol. 2009) 23

Products for MSLNL Gene

Sources for MSLNL Gene

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