MSLNL Gene
protein-coding GIFtS: 31
GCID: GC16M000819
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mesothelin-like(Previous name: chromosome 16 open reading frame 37 )
(Previous symbol: C16orf37)
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Aliases
for MSLNL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mesothelin-Like1 | | C16orf371 2 3 | | MPFL1 2 3 | | Chromosome 16 Open Reading Frame 371 | | Pre-Pro-Megakaryocyte-Potentiating-Factor-Like1 |
Export aliases for MSLNL gene to outside databasesPrevious GC identifers: GC16M000766 GC16M000741 |
Summaries
for MSLNL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MSLNL_HUMAN, Q96KJ4Function: May play a role in cellular adhesion (By similarity)
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Genomic Views
for MSLNL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MSLNL gene promoter:
Elk-1 Spz1 POU2F1 POU2F1a MyoD Nkx2-5 NF-Y E47 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MSLNL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSLNL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3MSLNL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M000819: view genomic region
(about GC identifiers)
Start:
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819,428 bp from pter |
End:
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833,370 bp from pter |
Size:
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13,943 bases |
Orientation:
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minus strand |
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Proteins
for MSLNL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MSLNL_HUMAN, Q96KJ4 (See
protein sequence)Recommended Name: Mesothelin-like protein precursor Size: 702 amino acids; 74540 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAK61254.1; Type=Erroneous gene model prediction; Note=The sequence shown is based on geneprediction by similarity with the mouse ortholog; Sequence=EAW85717.1; Type=Erroneous gene model prediction; Note=Thesequence shown is based on gene prediction by similarity with the mouse ortholog;Explore the universe of human proteins at neXtProt for MSLNL: NX_Q96KJ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96KJ4
MSLNL Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000441381 ENSP00000415767 ENSP00000293892
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
MSLNL for ontologies About GeneDecksing
MSLNL Antibody Products:
Assay Products for MSLNL: |
Protein
Domains /
Families
for MSLNL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MSLNL for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96KJ4ProtoNet protein and cluster: Q96KJ4 UniProtKB/Swiss-Prot: MSLNL_HUMAN, Q96KJ4Similarity: Belongs to the mesothelin family |
Function
for MSLNL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MSLNL_HUMAN, Q96KJ4Function: May play a role in cellular adhesion (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSLNL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSLNL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MSLNL (NM_001025190) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MSLNL | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MSLNL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSLNL |
|
Pathways & Interactions
for MSLNL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSLNL
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- |
MSLNL for ontologies About GeneDecksing
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Drugs & Compounds
for MSLNL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MSLNL
Search CenterWatch for drugs/clinical trials and news about MSLNL
|
Transcripts
for MSLNL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for MSLNL gene: NM_001025190.1 4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000543963 ENST00000537221 ENST00000442466 ENST00000293892(uc002cjz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSLNL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSLNL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MSLNL (NM_001025190) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MSLNL | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MSLNL |
GeneLoc Exon Structure
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Expression
for MSLNL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MSLNL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MSLNL Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for MSLNL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSLNL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSLNL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSLNL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSLNL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSLNL |
Orthologs
for MSLNL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for MSLNL gene from 2/5 species (see all 5) About this table
Species with no ortholog for MSLNL
ENSEMBL Gene Tree for MSLNL (if available)
TreeFam Gene Tree for MSLNL (if available) |
Paralogs
for MSLNL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MSLNL gene
- MSLN2
MSLNL for paralogs About GeneDecksing
|
Genomic Variants
for MSLNL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MSLNL (819428 - 833370 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for MSLNL
7 CNVs: 10493 29986 3987 49763 5329 30732 29983 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MSLNL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MSLNL for disorders About GeneDecksing
3  diseases for MSLNL: About MalaCardspatellofemoral pain syndrome hemarthrosis paine syndrome
2 diseases from the University of Copenhagen DISEASES database for MSLNL:Patellofemoral pain syndrome Hemarthrosis Export disorders for MSLNL gene to outside databases
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Publications
for MSLNL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MSLNL gene integrated from 9 sources:
(articles sorted by number of sources associating them with MSLNL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
- Inactivation of the MSLNL gene encoding mesothelin-lik e protein during African great ape evolution. (PubMed id 22265842)1 Kim D.W....Hahn Y. (2012)
- Soluble mesothelin, megakaryocyte potentiating factor , and osteopontin as markers of patient response and outcome in mesothelioma. (PubMed id 21841505)1 Hollevoet K....van Meerbeeck J.P. (2011)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats. (PubMed id 19128473)9 Sathyanarayana B.K....Lee B. (2009)
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External Searches for MSLNL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MSLNL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MSLNL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MSLNL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MSLNL | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MSLNL gene:
Search GeneIP for patents involving MSLNL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MSLNL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MSLNL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSLNL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSLNL | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MSLNL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSLNL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSLNL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MSLNL | | OriGene Custom Protein Services for MSLNL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MSLNL | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSLNL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSLNL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSLNL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSLNL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSLNL |
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 | | | MSLNL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSLNL |
|  |  |  | | | | Search ThermoFisher Antibodies for MSLNL |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MSLNL |
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