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Aliases for MSLN Gene

Aliases for MSLN Gene

  • Mesothelin 2 3 3 5
  • Pre-Pro-Megakaryocyte-Potentiating Factor 3 4
  • CAK1 Antigen 3 4
  • MPF 3 4
  • Soluble MPF Mesothelin Related Protein 3
  • Megakaryocyte Potentiating Factor 3
  • SMRP 3

External Ids for MSLN Gene

Previous GeneCards Identifiers for MSLN Gene

  • GC16P000829
  • GC16P000750
  • GC16P000751
  • GC16P000811
  • GC16P000732
  • GC16P000810
  • GC16P000697
  • GC16P000702
  • GC16P000724
  • GC16P000774
  • GC16P000791
  • GC16P000839
  • GC16P000869
  • GC16P000899

Summaries for MSLN Gene

Entrez Gene Summary for MSLN Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for MSLN Gene

MSLN (Mesothelin) is a Protein Coding gene. Diseases associated with MSLN include Ovarian Cancer and Malignant Pleural Mesothelioma. Among its related pathways are Adhesion and Metabolism of proteins. An important paralog of this gene is MSLNL.

UniProtKB/Swiss-Prot for MSLN Gene

  • Membrane-anchored forms may play a role in cellular adhesion.

  • Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

Gene Wiki entry for MSLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSLN Gene

Genomics for MSLN Gene

Regulatory Elements for MSLN Gene

Enhancers for MSLN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000759 1.2 FANTOM5 Ensembl ENCODE 38.5 +0.4 388 3.7 KLF1 MXI1 ZFP64 ZNF266 KLF17 MAX HIC1 ZFHX2 GLIS2 POLR2A MSLN GC16P000926 GC16P000927 ENSG00000279136
GH16F000757 0.6 Ensembl 23.3 -3.0 -3032 1.0 HDGF ATF1 PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF766 MSLN JMJD8 TMEM204 MPG TPSG1 ENSG00000260954 WASH4P LOC102724992 NARFL
GH16F000754 1.2 Ensembl ENCODE 17.5 -5.7 -5732 0.8 KLF1 PKNOX1 ZNF335 ZNF316 FOXK2 IKZF1 ZNF341 PBX2 ZBTB33 EMSY MSLN LOC102724992 NARFL
GH16F000794 1.1 Ensembl ENCODE 10.1 +38.5 38533 9.5 ZFP64 ZNF76 GLIS2 SCRT2 RCOR1 EGR2 USF2 REST RAD51 MTA1 MSLN CHTF18 RPUSD1 MSLNL NARFL GNG13
GH16F000787 0.2 ENCODE 9.5 +27.9 27888 2.8 PKNOX1 CREB3L1 ARID4B SIN3A GLI4 ZNF2 GLIS2 ELK1 ZNF143 ZNF207 ENSG00000261505 ENSG00000260954 JMJD8 ENSG00000260051 ENSG00000261207 IFT140 CHTF18 HN1L LOC105371038 MSLN
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MSLN on UCSC Golden Path with GeneCards custom track

Genomic Location for MSLN Gene

Chromosome:
16
Start:
760,732 bp from pter
End:
768,865 bp from pter
Size:
8,134 bases
Orientation:
Plus strand

Genomic View for MSLN Gene

Genes around MSLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSLN Gene

Proteins for MSLN Gene

  • Protein details for MSLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13421-MSLN_HUMAN
    Recommended name:
    Mesothelin
    Protein Accession:
    Q13421
    Secondary Accessions:
    • D3DU65
    • Q14859
    • Q4VQD5
    • Q96GR6
    • Q96KJ5
    • Q9BR17
    • Q9BTR2
    • Q9UCB2
    • Q9UK57

    Protein attributes for MSLN Gene

    Size:
    630 amino acids
    Molecular mass:
    68986 Da
    Quaternary structure:
    • Interacts with MUC16.

    Three dimensional structures from OCA and Proteopedia for MSLN Gene

    Alternative splice isoforms for MSLN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSLN Gene

Post-translational modifications for MSLN Gene

  • Both MPF and the cleaved form of mesothelin are N-glycosylated.
  • Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • Glycosylation at Asn 57, Asn 388, Asn 496, and Asn 523
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MSLN Gene

Domains & Families for MSLN Gene

Protein Domains for MSLN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13421

UniProtKB/Swiss-Prot:

MSLN_HUMAN :
  • Belongs to the mesothelin family.
Family:
  • Belongs to the mesothelin family.
genes like me logo Genes that share domains with MSLN: view

No data available for Gene Families for MSLN Gene

Function for MSLN Gene

Molecular function for MSLN Gene

GENATLAS Biochemistry:
Mesothelin,megakaryocyte potentiating factor. Expressed by mesothelial,detectable in sera from patients with ovarian carcinoma. Putatively involved in cell adhesion
UniProtKB/Swiss-Prot Function:
Membrane-anchored forms may play a role in cellular adhesion.
UniProtKB/Swiss-Prot Function:
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

Gene Ontology (GO) - Molecular Function for MSLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14676194
genes like me logo Genes that share ontologies with MSLN: view
genes like me logo Genes that share phenotypes with MSLN: view

Animal Models for MSLN Gene

MGI Knock Outs for MSLN:

Animal Model Products

miRNA for MSLN Gene

miRTarBase miRNAs that target MSLN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSLN Gene

Localization for MSLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSLN Gene

Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.
Megakaryocyte-potentiating factor: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSLN Gene COMPARTMENTS Subcellular localization image for MSLN gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MSLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA,IBA --
genes like me logo Genes that share ontologies with MSLN: view

Pathways & Interactions for MSLN Gene

genes like me logo Genes that share pathways with MSLN: view

Pathways by source for MSLN Gene

Gene Ontology (GO) - Biological Process for MSLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS 8552591
GO:0007160 cell-matrix adhesion IBA --
GO:0031016 pancreas development IEA --
genes like me logo Genes that share ontologies with MSLN: view

No data available for SIGNOR curated interactions for MSLN Gene

Drugs & Compounds for MSLN Gene

(4) Drugs for MSLN Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AMATUXIMAB Pharma 0
SS1(DSFV)-PE38 Pharma 0

(4) Additional Compounds for MSLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MSLN: view

Transcripts for MSLN Gene

Unigene Clusters for MSLN Gene

Mesothelin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSLN Gene

No ASD Table

Relevant External Links for MSLN Gene

GeneLoc Exon Structure for
MSLN
ECgene alternative splicing isoforms for
MSLN

Expression for MSLN Gene

mRNA expression in normal human tissues for MSLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSLN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x16.4), Lung (x12.1), and Fallopian Tube (x5.2).

Protein differential expression in normal tissues from HIPED for MSLN Gene

This gene is overexpressed in Amniocyte (20.6), Cervix (15.8), Testis (15.1), and Ovary (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MSLN Gene



NURSA nuclear receptor signaling pathways regulating expression of MSLN Gene:

MSLN

SOURCE GeneReport for Unigene cluster for MSLN Gene:

Hs.408488

mRNA Expression by UniProt/SwissProt for MSLN Gene:

Q13421-MSLN_HUMAN
Tissue specificity: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
genes like me logo Genes that share expression patterns with MSLN: view

Primer Products

No data available for Protein tissue co-expression partners for MSLN Gene

Orthologs for MSLN Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSLN 34 35
  • 97.26 (n)
dog
(Canis familiaris)
Mammalia MSLN 34 35
  • 76.78 (n)
cow
(Bos Taurus)
Mammalia MSLN 34 35
  • 74.46 (n)
rat
(Rattus norvegicus)
Mammalia Msln 34
  • 71.23 (n)
mouse
(Mus musculus)
Mammalia Msln 34 16 35
  • 70.96 (n)
oppossum
(Monodelphis domestica)
Mammalia MSLN 35
  • 21 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSLN 34 35
  • 48.6 (n)
lizard
(Anolis carolinensis)
Reptilia MSLN 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733400 34
  • 40.69 (n)
zebrafish
(Danio rerio)
Actinopterygii MSLN (2 of 2) 35
  • 22 (a)
OneToMany
MSLN (1 of 2) 35
  • 6 (a)
OneToMany
Species where no ortholog for MSLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSLN Gene

ENSEMBL:
Gene Tree for MSLN (if available)
TreeFam:
Gene Tree for MSLN (if available)

Paralogs for MSLN Gene

Paralogs for MSLN Gene

genes like me logo Genes that share paralogs with MSLN: view

Variants for MSLN Gene

Sequence variations from dbSNP and Humsavar for MSLN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1057147 -- 768,802(+) GGGTG(A/G)TCCCC upstream-variant-2KB, utr-variant-3-prime
rs1076675 -- 762,539(+) GGGTG(C/T)GGACA intron-variant, utr-variant-5-prime
rs111316370 -- 758,855(+) GTGAG(C/T)CACTG upstream-variant-2KB
rs111354731 -- 761,110(+) ACTCC(C/T)GTCTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111498420 -- 768,928(+) CTTGC(A/G)CCCCC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MSLN Gene

Variant ID Type Subtype PubMed ID
dgv4825n54 CNV loss 21841781
dgv4827n54 CNV loss 21841781
dgv4828n54 CNV gain 21841781
dgv4829n54 CNV loss 21841781
dgv4830n54 CNV gain+loss 21841781
dgv4831n54 CNV gain 21841781
dgv772e212 CNV loss 25503493
esv2422427 CNV duplication 17116639
esv27245 CNV gain+loss 19812545
esv3637582 CNV gain 21293372
nsv1070732 CNV deletion 25765185
nsv1143797 CNV deletion 24896259
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv1702 CNV insertion 18451855
nsv457311 CNV loss 19166990
nsv457312 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv517488 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571023 CNV loss 21841781
nsv571025 CNV gain 21841781
nsv571030 CNV gain 21841781
nsv571032 CNV loss 21841781
nsv571033 CNV gain 21841781
nsv571034 CNV gain 21841781
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for MSLN Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSLN Gene

Disorders for MSLN Gene

MalaCards: The human disease database

(20) MalaCards diseases for MSLN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
pancreatic cancer
  • pancreatic carcinoma, somatic
mesothelioma, somatic
  • mesothelioma, malignant
malignant biphasic mesothelioma
  • mesothelioma, biphasic, malignant
- elite association - COSMIC cancer census association via MalaCards
Search MSLN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MSLN_HUMAN
  • Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. {ECO:0000269 PubMed:15897581}.

Relevant External Links for MSLN

Genetic Association Database (GAD)
MSLN
Human Genome Epidemiology (HuGE) Navigator
MSLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSLN
genes like me logo Genes that share disorders with MSLN: view

No data available for Genatlas for MSLN Gene

Publications for MSLN Gene

  1. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. (PMID: 8552591) Chang K. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
  2. Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma. (PMID: 16857795) Onda M. … Pastan I. (Clin. Cancer Res. 2006) 3 4 22 64
  3. Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. (PMID: 15897581) Ho M. … Pastan I. (Clin. Cancer Res. 2005) 3 4 22 64
  4. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. (PMID: 14676194) Rump A. … Miyajima A. (J. Biol. Chem. 2004) 3 4 22 64
  5. Characterization of human mesothelin transcripts in ovarian and pancreatic cancer. (PMID: 15140265) Muminova Z.E. … Shaw D.R. (BMC Cancer 2004) 3 4 22 64

Products for MSLN Gene

Sources for MSLN Gene

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