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MSLN Gene

protein-coding   GIFtS: 59
GCID: GC16P000810

Mesothelin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
mesothelin1 2     SMRP2
Pre-Pro-Megakaryocyte-Potentiating Factor2 3     Megakaryocyte Potentiating Factor2
MPF2 3     Soluble MPF Mesothelin Related Protein2
CAK1 Antigen2 3     

External Ids:    HGNC: 73711   Entrez Gene: 102322   Ensembl: ENSG000001028547   OMIM: 6010515   UniProtKB: Q134213   

Export aliases for MSLN gene to outside databases

Previous GC identifers: GC16P000829 GC16P000750 GC16P000751 GC16P000811 GC16P000732 GC16P000697 GC16P000702 GC16P000724 GC16P000774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSLN Gene:
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and
mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone
marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may
function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers
and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.(provided
by RefSeq, Apr 2010)

GeneCards Summary for MSLN Gene:
MSLN (mesothelin) is a protein-coding gene. Diseases associated with MSLN include malignant biphasic mesothelioma, and malignant pleural mesothelioma. An important paralog of this gene is MSLNL.

UniProtKB/Swiss-Prot: MSLN_HUMAN, Q13421
Function: Membrane-anchored forms may play a role in cellular adhesion
Function: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro

Gene Wiki entry for MSLN (Mesothelin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSLN gene promoter:
         Max1   p53   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSLN promoter sequence
   Search Chromatin IP Primers for MSLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MSLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSLN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000810:  view genomic region     (about GC identifiers)

Start:
810,762 bp from pter      End:
818,865 bp from pter
Size:
8,104 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MSLN_HUMAN, Q13421 (See protein sequence)
Recommended Name: Mesothelin precursor  
Size: 630 amino acids; 68986 Da
Subunit: Interacts with MUC16
1 PDB 3D structure from and Proteopedia for MSLN:
4F3F (3D)    
Secondary accessions: D3DU65 Q14859 Q4VQD5 Q96GR6 Q96KJ5 Q9BR17 Q9BTR2 Q9UCB2 Q9UK57
Alternative splicing: 4 isoforms:  Q13421-1   Q13421-3   Q13421-2   Q13421-4   (Soluble form found in the sera from patients with ovarian carcinoma)

Explore the universe of human proteins at neXtProt for MSLN: NX_Q13421

Explore proteomics data for MSLN at MOPED

Post-translational modifications: 

  • Both MPF and the cleaved form of mesothelin are N-glycosylated1
  • Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the
    cleaved form of mesothelin1
  • Glycosylation2 at Asn57, Asn388, Asn496, Asn523
  • Modification sites at PhosphoSitePlus

  • See MSLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001170826.1  NP_005814.2  NP_037536.2  

    ENSEMBL proteins: 
     ENSP00000456008   ENSP00000442965   ENSP00000456702   ENSP00000372313   ENSP00000456132  
     ENSP00000458003   ENSP00000454295   ENSP00000457847  

    MSLN Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MSLN
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    Novus Biologicals MSLN Protein
    Novus Biologicals MSLN Lysates
    Sino Biological Recombinant Protein for MSLN
    Sino Biological Cell Lysate for MSLN
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    Cloud-Clone Corp. Proteins for MSLN

    MSLN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MSLN
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    LSBio Antibodies in human, mouse, rat for MSLN

    MSLN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MSLN
    Cloud-Clone Corp. CLIAs for MSLN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026664 Stereocilin_related
     IPR010335 Mesothelin

    Graphical View of Domain Structure for InterPro Entry Q13421

    ProtoNet protein and cluster: Q13421

    UniProtKB/Swiss-Prot: MSLN_HUMAN, Q13421
    Similarity: Belongs to the mesothelin family


    MSLN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSLN_HUMAN, Q13421
    Function: Membrane-anchored forms may play a role in cellular adhesion
    Function: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro

         Genatlas biochemistry entry for MSLN:
    Mesothelin,megakaryocyte potentiating factor. Expressed by mesothelial,detectable in sera from patients with
    ovarian carcinoma. Putatively involved in cell adhesion

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14676194
         
    MSLN for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MSLN:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Msln):
     normal 

    MSLN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mslntm1Ipa for MSLN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSLN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSLN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSLN

    miRNA
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    miRTarBase miRNAs that target MSLN:
    hsa-mir-335-5p (MIRT019192)

    Block miRNA regulation of human, mouse, rat MSLN using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat MSLN

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MSLN (NM_005823)
    Sino Biological Human cDNA Clone for MSLN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSLN

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSLN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MSLN_HUMAN, Q13421: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus
    MSLN_HUMAN, Q13421: Megakaryocyte-potentiating factor: Secreted
    MSLN_HUMAN, Q13421: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    plasma membrane5
    endosome2
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--
    GO:0016020membrane NAS8552591

    MSLN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MSLN: 
              Cell Lineage Identification in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MSLN

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MSLN (Q134213 ENSP000003723134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC16Q8WXI73, ENSP000003810084I2D: score=1 STRING: ENSP00000381008
    RSG1ENSP000003647494STRING: ENSP00000364749
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS8552591
    GO:0031016pancreas development IEA--

    MSLN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSLN

    6 Novoseek inferred chemical compound relationships for MSLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b 723 69.3 9 16415794 (3), 12883236 (2), 14652817 (1), 18318582 (1) (see all 6)
    exotoxin-a 36 1 12479219 (1)
    hyaluronic acid 2 5 19302997 (3)
    oligonucleotide 0 1 12827615 (1)
    estrogen 0 2 16306790 (1), 15897574 (1)
    vegf 0 3 15161681 (1), 20476844 (1), 16061277 (1)



    MSLN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MSLN gene (3 alternative transcripts): 
    NM_001177355.1  NM_005823.5  NM_013404.4  

    Unigene Cluster for MSLN:

    Mesothelin
    Hs.408488  [show with all ESTs]
    Unigene Representative Sequence: BC003512
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563941 ENST00000545450 ENST00000566549(uc002cju.1 uc002cjt.1 uc010brd.1)
    ENST00000382862(uc002cjw.2) ENST00000563651 ENST00000569566 ENST00000566269
    ENST00000561896(uc002cjy.1)
    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MSLN (NM_005823)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSLN
    Primer
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    OriGene qPCR primer pairs and template standards for MSLN
    OriGene qSTAR qPCR primer pairs in human, mouse for MSLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSLN
      QuantiTect SYBR Green Assays in human, mouse, rat MSLN
      QuantiFast Probe-based Assays in human, mouse, rat MSLN

    Additional mRNA sequence: 

    AF180951.1 AY743922.1 BC003512.1 BC009272.2 D49441.1 U40434.1 

    8 DOTS entries:

    DT.314763  DT.95271551  DT.97807030  DT.120717777  DT.95271552  DT.99982268  DT.97783702  DT.100787392 

    Selected AceView cDNA sequences (see all 154):

    AW474904 CR606099 BX105104 AI567987 AI582411 BI772405 CR616603 BM676615 
    AL545401 AI469957 BM763596 AA488541 BM770227 CB266931 BM792118 BI333483 
    BM848270 BM845371 BM714235 AL571138 NM_005823 BM763535 AI342440 BI770307 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTGCAG
    MSLN Expression
    About this image


    MSLN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
             Oviduct
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Meningeal Cells Anterior Meninges
     
     Lung (Respiratory System)
             Alveolar type II cells
    MSLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408488

    UniProtKB/Swiss-Prot: MSLN_HUMAN, Q13421
    Tissue specificity: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in
    mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at
    protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including MSLN: 
              Cell Lineage Identification in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MSLN gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msln1 , 5 mesothelin1, 5 70.96(n)1
    58.91(a)1
      17 (12.85 cM)5
    560471  NM_018857.11  NP_061345.11 
     257486145 
    chicken
    (Gallus gallus)
    Aves MSLN1 mesothelin 48.6(n)
    39.63(a)
      416534  XM_414835.3  XP_414835.3 
    lizard
    (Anolis carolinensis)
    Reptilia MSLN6
    mesothelin
    37(a)
    1 ↔ 1
    GL343650.1(252153-268774)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017334001 uncharacterized LOC101733400 40.69(n)
    29.2(a)
      101733400  XM_004918306.1  XP_004918363.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MSLN (1 of 2)6
    MSLN (2 of 2)6
    mesothelin
    6(a)
    22(a)
    1 ↔ many
    1 ↔ many
    3(42728293-42774364) ENSDARG00000052664
    1(60198285-60201640) ENSDARG00000090320


    ENSEMBL Gene Tree for MSLN (if available)
    TreeFam Gene Tree for MSLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSLN gene
    MSLNL2  

    MSLN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSLN (see all 505)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125969521,2
    C,H--808770(+) tttcaT/Ccgtgt 2 -- us2k15Minor allele frequency- C:0.00NA WA 10
    rs125978671,2
    C,H--808782(+) agccaG/Agatgg 2 -- us2k15Minor allele frequency- A:0.00NA WA 10
    rs1887033591,2
    --808785(+) CAAGAG/TGGTCT 2 -- us2k10--------
    rs125969551,2
    C,H--808791(+) ggtctG/Cgatct 2 -- us2k14Minor allele frequency- C:0.00NA 8
    rs125969711,2
    C,H--808803(+) ctgacT/Ctcatg 2 -- us2k14Minor allele frequency- C:0.00NA 8
    rs713822841,2
    C--808816(+) CTGCCC/TGCCTC 2 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1836650821,2
    --808817(+) TGCCTA/GCCTCG 2 -- us2k10--------
    rs1113163701,2
    C,F--808855(+) GTGAGC/TCACTG 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs125969731,2
    C,F,A,H--808865(+) gcgccC/TggcAt 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1924335271,2
    --808910(+) TCTTGC/TTCTGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MSLN (810762 - 818865 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MSLN (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv1702CNV Insertion18451855
    dgv2499n71CNV Loss21882294
    dgv2475n71CNV Loss21882294
    dgv2500n71CNV Loss21882294
    nsv904796CNV Loss21882294
    nsv904797CNV Loss21882294
    nsv526903CNV Loss19592680
    nsv471063CNV Loss18288195
    dgv2485n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MSLN
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601051    OMIM disorders: --

    UniProtKB/Swiss-Prot: MSLN_HUMAN, Q13421
  • Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer

  • Selected diseases for MSLN (see all 40):    
    About MalaCards
    malignant biphasic mesothelioma    malignant pleural mesothelioma    bile duct adenoma    thoracic cancer
    pancreatic ductal carcinoma    malignant mesothelioma    epithelioid sarcoma    benign mesothelioma
    asbestosis    pancreatic ductal adenocarcinoma    endocervicitis    thymic carcinoma
    squamous cell carcinoma    ovarian cancer    pancreatic cancer    noma
    renal clear cell carcinoma    gastrointestinal stromal tumor    gastric adenocarcinoma    thymoma

    7 diseases from the University of Copenhagen DISEASES database for MSLN:
    Benign mesothelioma     Malignant mesothelioma     Malignant pleural mesothelioma     Ovarian cancer
    Pancreatic cancer     Asbestosis     Carcinoma

    MSLN for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MSLN gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mesothelioma 90.3 162 15897581 (7), 16857795 (7), 16776777 (5), 18316566 (5) (see all 56)
    malignant mesothelioma 83.9 17 14652817 (2), 17559144 (2), 10916757 (2), 18281122 (1) (see all 14)
    pleural malignant mesothelioma 80.8 11 19201924 (2), 16415794 (1), 18670302 (1), 18394747 (1) (see all 8)
    ovarian cancer 77.7 96 15897581 (6), 15526007 (6), 18768519 (3), 19423517 (3) (see all 44)
    ovarian carcinoma 68 20 18559570 (3), 17214332 (2), 19293794 (2), 18788634 (1) (see all 14)
    adenocarcinoma 65.3 79 16416732 (6), 17304533 (5), 15725808 (4), 18691948 (4) (see all 32)
    pancreatic cancer 61.4 50 18281514 (5), 19010822 (3), 19843662 (2), 11751476 (2) (see all 18)
    adenocarcinoma lung 57.6 8 17332303 (2), 12640097 (1), 15725808 (1), 12883236 (1) (see all 6)
    tumors 55.8 141 14576474 (6), 18281122 (5), 18281514 (5), 16082249 (5) (see all 60)
    ovarian tumor benign 53.5 2 15385104 (1), 17214332 (1)

    Genetic Association Database (GAD): MSLN
    Human Genome Epidemiology (HuGE) Navigator: MSLN (2 documents)

    Export disorders for MSLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSLN gene, integrated from 10 sources (see all 258):
    (articles sorted by number of sources associating them with MSLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. (PubMed id 8552591)1, 2, 3, 9 Chang K. and Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Molecular cloning and expression of megakaryocyte potentiating factor cDNA. (PubMed id 7665620)1, 2, 3 Kojima T....Yamaguchi N. (J. Biol. Chem. 1995)
    3. Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma. (PubMed id 16857795)1, 2, 9 Onda M....Pastan I. (Clin. Cancer Res. 2006)
    4. Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. (PubMed id 15897581)1, 2, 9 Ho M.... Pastan I. (Clin. Cancer Res. 2005)
    5. Characterization of human mesothelin transcripts in ovarian and pancreatic cancer. (PubMed id 15140265)1, 2, 9 Muminova Z.E.... Shaw D.R. (BMC Cancer 2004)
    6. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. (PubMed id 14676194)1, 2, 9 Rump A....Miyajima A. (J. Biol. Chem. 2004)
    7. A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5. (PubMed id 8288629)1, 2, 9 Yamaguchi N.... Ochi N. (J. Biol. Chem. 1994)
    8. Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma. (PubMed id 10500211)1, 2, 9 Scholler N....Hellstroem I. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    9. Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. (PubMed id 22787150)1, 2 Ma J.... Xia D. (J. Biol. Chem. 2012)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10232 HGNC: 7371 AceView: MSLN Ensembl:ENSG00000102854 euGenes: HUgn10232
    ECgene: MSLN H-InvDB: MSLN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSLN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSLN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSLN gene:
    Search GeneIP for patents involving MSLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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