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Aliases for MSLN Gene

Aliases for MSLN Gene

  • Mesothelin 2 3
  • Pre-Pro-Megakaryocyte-Potentiating Factor 3 4
  • CAK1 Antigen 3 4
  • MPF 3 4
  • Soluble MPF Mesothelin Related Protein 3
  • Megakaryocyte Potentiating Factor 3
  • SMRP 3

External Ids for MSLN Gene

Summaries for MSLN Gene

Entrez Gene Summary for MSLN Gene

  • This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

GeneCards Summary for MSLN Gene

MSLN (Mesothelin) is a Protein Coding gene. Diseases associated with MSLN include pancreatic cancer and malignant biphasic mesothelioma.

UniProtKB/Swiss-Prot for MSLN Gene

  • Membrane-anchored forms may play a role in cellular adhesion

  • Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro

Gene Wiki entry for MSLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSLN Gene

Genomics for MSLN Gene

Genomic Location for MSLN Gene

Start:
643,262 bp from pter
End:
768,865 bp from pter
Size:
125,604 bases
Orientation:
Plus strand

Genomic View for MSLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSLN Gene

Regulatory Elements for MSLN Gene

Transcription factor binding sites by QIAGEN in the MSLN gene promoter:

Proteins for MSLN Gene

  • Protein details for MSLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13421-MSLN_HUMAN
    Recommended name:
    Mesothelin
    Protein Accession:
    Q13421
    Secondary Accessions:
    • D3DU65
    • Q14859
    • Q4VQD5
    • Q96GR6
    • Q96KJ5
    • Q9BR17
    • Q9BTR2
    • Q9UCB2
    • Q9UK57

    Protein attributes for MSLN Gene

    Size:
    630 amino acids
    Molecular mass:
    68986 Da
    Quaternary structure:
    • Interacts with MUC16.

    Three dimensional structures from OCA and Proteopedia for MSLN Gene

    Alternative splice isoforms for MSLN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSLN Gene

Proteomics data for MSLN Gene at MOPED

Post-translational modifications for MSLN Gene

  • Both MPF and the cleaved form of mesothelin are N-glycosylated.
  • Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn57, Asn388, Asn496, and Asn523

No data available for DME Specific Peptides for MSLN Gene

Domains for MSLN Gene

Protein Domains for MSLN Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MSLN_HUMAN
Family:
  • Belongs to the mesothelin family.:
    • Q13421
genes like me logo Genes that share domains with MSLN: view

No data available for Gene Families for MSLN Gene

Function for MSLN Gene

Molecular function for MSLN Gene

GENATLAS Biochemistry: Mesothelin,megakaryocyte potentiating factor. Expressed by mesothelial,detectable in sera from patients with ovarian carcinoma. Putatively involved in cell adhesion
UniProtKB/Swiss-Prot Function: Membrane-anchored forms may play a role in cellular adhesion
UniProtKB/Swiss-Prot Function: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro

Gene Ontology (GO) - Molecular Function for MSLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14676194
genes like me logo Genes that share ontologies with MSLN: view

Phenotypes for MSLN Gene

genes like me logo Genes that share phenotypes with MSLN: view

Animal Models for MSLN Gene

MGI Knock Outs for MSLN:

miRNA for MSLN Gene

miRTarBase miRNAs that target MSLN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MSLN Gene

Localization for MSLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSLN Gene

Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.
Megakaryocyte-potentiating factor: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSLN Gene COMPARTMENTS Subcellular localization image for MSLN gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
endosome 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MSLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane NAS 8552591
genes like me logo Genes that share ontologies with MSLN: view

Pathways for MSLN Gene

SuperPathways for MSLN Gene

No Data Available

Gene Ontology (GO) - Biological Process for MSLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS 8552591
GO:0031016 pancreas development IEA --
genes like me logo Genes that share ontologies with MSLN: view

No data available for Pathways by source for MSLN Gene

Compounds for MSLN Gene

(6) Novoseek inferred chemical compound relationships for MSLN Gene

Compound -log(P) Hits PubMed IDs
b 723 69.3 9
exotoxin-a 36 1
hyaluronic acid 2 3
oligonucleotide 0 1
estrogen 0 2
genes like me logo Genes that share compounds with MSLN: view

Transcripts for MSLN Gene

Unigene Clusters for MSLN Gene

Mesothelin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSLN Gene

No ASD Table

Relevant External Links for MSLN Gene

GeneLoc Exon Structure for
MSLN
ECgene alternative splicing isoforms for
MSLN

Expression for MSLN Gene

mRNA expression in normal human tissues for MSLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSLN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (16.4), Lung (12.1), and Fallopian Tube (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MSLN Gene

SOURCE GeneReport for Unigene cluster for MSLN Gene Hs.408488

mRNA Expression by UniProt/SwissProt for MSLN Gene

Q13421-MSLN_HUMAN
Tissue specificity: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
genes like me logo Genes that share expressions with MSLN: view

Orthologs for MSLN Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSLN 36
  • 97.26 (n)
  • 95.56 (a)
MSLN 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSLN 36
  • 74.46 (n)
  • 63.74 (a)
MSLN 37
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSLN 36
  • 76.78 (n)
  • 66.76 (a)
MSLN 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msln 36
  • 70.96 (n)
  • 58.91 (a)
Msln 16
Msln 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSLN 37
  • 21 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msln 36
  • 71.23 (n)
  • 58.91 (a)
chicken
(Gallus gallus)
Aves MSLN 36
  • 48.6 (n)
  • 39.63 (a)
MSLN 37
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSLN 37
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733400 36
  • 40.69 (n)
  • 29.2 (a)
zebrafish
(Danio rerio)
Actinopterygii MSLN (1 of 2) 37
  • 6 (a)
OneToMany
MSLN (2 of 2) 37
  • 22 (a)
OneToMany
Species with no ortholog for MSLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSLN Gene

ENSEMBL:
Gene Tree for MSLN (if available)
TreeFam:
Gene Tree for MSLN (if available)

Paralogs for MSLN Gene

No data available for Paralogs for MSLN Gene

Variants for MSLN Gene

Sequence variations from dbSNP and Humsavar for MSLN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs755121 -- 763,018(-) CACAT(C/T)TTTCC intron-variant
rs1076675 -- 762,539(+) GGGTG(C/T)GGACA intron-variant, utr-variant-5-prime
rs1737340 -- 765,628(+) ACCCC(A/G)ATCCC intron-variant
rs2235503 -- 760,593(+) GCCCA(A/C)CGAGG upstream-variant-2KB
rs2235504 -- 760,655(+) TGTCC(A/G)AGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MSLN Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
nsv457311 CNV Loss 19166990
nsv1702 CNV Insertion 18451855
dgv2498n71 CNV Loss 21882294
dgv2499n71 CNV Loss 21882294
dgv2500n71 CNV Loss 21882294
nsv457312 CNV Loss 19166990
nsv517488 CNV Loss 19592680
esv27245 CNV Gain+Loss 19812545

Relevant External Links for MSLN Gene

HapMap Linkage Disequilibrium report
MSLN

Disorders for MSLN Gene

UniProtKB/Swiss-Prot

MSLN_HUMAN
  • Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. {ECO:0000269 PubMed:15897581}.

(30) Novoseek inferred disease relationships for MSLN Gene

Disease -log(P) Hits PubMed IDs
mesothelioma 90.3 121
malignant mesothelioma 83.9 17
pleural malignant mesothelioma 80.8 9
ovarian cancer 77.7 74
ovarian carcinoma 68 18

Relevant External Links for MSLN

Genetic Association Database (GAD)
MSLN
Human Genome Epidemiology (HuGE) Navigator
MSLN
genes like me logo Genes that share disorders with MSLN: view

Publications for MSLN Gene

  1. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. (PMID: 8552591) Chang K. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. (PMID: 14676194) Rump A. … Miyajima A. (J. Biol. Chem. 2004) 3 4 23
  3. Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma. (PMID: 10500211) Scholler N. … Hellstroem I. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  4. Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. (PMID: 15897581) Ho M. … Pastan I. (Clin. Cancer Res. 2005) 3 4 23
  5. Characterization of human mesothelin transcripts in ovarian and pancreatic cancer. (PMID: 15140265) Muminova Z.E. … Shaw D.R. (BMC Cancer 2004) 3 4 23

Products for MSLN Gene

  • Addgene plasmids for MSLN

Sources for MSLN Gene

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