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MSL3P1 Gene

pseudogene   GIFtS: 28
GCID: GC02M234776

Male-Specific Lethal 3 Homolog (Drosophila) Pseudogene 1

(Previous name: male-specific lethal 3-like 2 (Drosophila))
(Previous symbol: MSL3L2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Male-Specific Lethal 3 Homolog (Drosophila) Pseudogene 11 2
MSL3L21 2 3
Male-Specific Lethal 3-Like 2 (Drosophila)1
Male-Specific Lethal-3 Homolog 23
Male-Specific Lethal-3 Homolog Pseudogene 13
MSL3-Like 23

External Ids:    HGNC: 178371   Entrez Gene: 1515072   Ensembl: ENSG000002242877   UniProtKB: P0C8603   

Export aliases for MSL3P1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MSL3P1 Gene:
MSL3P1 (male-specific lethal 3 homolog (Drosophila) pseudogene 1) is a pseudogene.

UniProtKB/Swiss-Prot: MS3L2_HUMAN, P0C860
Function: May be involved in chromatin remodeling and transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MSL3P1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MSL3P1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSL3P1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

MSL3P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSL3P1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M234776:  view genomic region     (about GC identifiers)

Start:
234,774,083 bp from pter      End:
234,777,090 bp from pter
Size:
3,008 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MS3L2_HUMAN, P0C860 (See protein sequence)
Recommended Name: Putative male-specific lethal-3 protein-like 2  
Size: 447 amino acids; 51070 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for MSL3P1: NX_P0C860

Explore proteomics data for MSL3P1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MSL3P1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008676 MRG
     IPR026541 MRG_dom

    Graphical View of Domain Structure for InterPro Entry P0C860

    ProtoNet protein and cluster: P0C860

    UniProtKB/Swiss-Prot: MS3L2_HUMAN, P0C860
    Similarity: Contains 1 chromo domain
    Similarity: Contains 1 MRG domain


    Find genes that share domains with MSL3P1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MS3L2_HUMAN, P0C860
    Function: May be involved in chromatin remodeling and transcriptional regulation (By similarity)

    Animal Models:

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MS3L2_HUMAN, P0C860: Nucleus (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MSL3P1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

        Search GeneGlobe Interaction Network for MSL3P1

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with MSL3P1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for MSL3P1 (MS3L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MSL3P1 gene: 
    NM_001166217.1  

    Unigene Cluster for MSL3P1:

    Male-specific lethal 3 homolog (Drosophila) pseudogene 1
    Hs.355809  [show with all ESTs]
    Unigene Representative Sequence: NR_024322
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438684(uc010znf.2) ENST00000440028
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    Additional mRNA sequence: 

    AK301707.1 AK316372.1 EF212288.1 NR_024322.1 

    1 DOTS entry:

    DT.95071801 

    Selected AceView cDNA sequences (see all 36):

    CR623684 BX384087 BG481237 CB119809 AI583380 BG482415 BV190919 BM835808 
    BQ772631 BE621131 AA806373 AA971161 BM809823 AA521265 BI831020 BU161504 
    AA476632 AI684766 BF057183 CB993239 AA355764 AA757978 BQ108692 BE543927 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSL3P1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MSL3P1 Expression
    About this image

    MSL3P1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSL3P1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.355809
        Custom PCR Arrays for MSL3P1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for MSL3P1 (if available)
    TreeFam Gene Tree for MSL3P1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSL3P1 gene
    1 SIMAP similar gene for MSL3P1 using alignment to 1 protein entry:     MS3L2_HUMAN:
    MSL3

    Find genes that share paralogs with MSL3P1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSL3P1 (see all 129)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs64316431,2
    C,F,A,H--234773700(+) CCACAA/GTGGGA 1 -- ds500124Minor allele frequency- G:0.39NS EA NA WA CSA 2528
    rs64316441,2
    C,F,A,H--234773729(+) TTTCTG/ATTAGG 1 -- ds500116Minor allele frequency- A:0.35NA NS WA CSA EA 632
    rs1930740071,2
    --234773752(+) GAAATA/CTTTTC 1 -- ds50010--------
    rs1861591,2
    C,F,O,H--234773876(-) ACCCAC/GATATT 1 -- ds500111Minor allele frequency- G:0.23NS EA NA WA 978
    rs2135431,2
    C,F,H--234774025(-) GCTACG/ATATTC 1 -- ds50019Minor allele frequency- A:0.05NS EA NA WA 956
    rs1884921,2
    C,F,A,H--234774076(-) TAACTT/CGGAGT 1 -- ds50019Minor allele frequency- C:0.05NS EA NA WA 944
    rs720259091,2
    C--234774082(+) TTAAT-/TTTTTT 1 -- ds50010--------
    rs1833311,2
    C,F,O,A,H--234774149(-) TGTTAT/CGGTTC 1 -- nc-transcript-variant16Minor allele frequency- C:0.31NS EA NA WA 974
    rs289007231,2
    C,F,H--234774205(+) TGCTTT/CCTTTA 1 -- nc-transcript-variant5Minor allele frequency- C:0.06NS EA 538
    rs1144397541,2
    F--234774246(+) GAACCG/TTCAGA 1 -- nc-transcript-variant1Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for MSL3P1 (234774083 - 234777090 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MSL3P1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3216CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MSL3P1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSL3P1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MSL3P1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. (PubMed id 20479123)1 Sharma G.G....Pandita T.K. (Mol. Cell. Biol. 2010)
    2. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PubMed id 16227571)1 Smith E.R.... Lucchesi J.C. (Mol. Cell. Biol. 2005)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151507 HGNC: 17837 AceView: LOC151507 Ensembl:ENSG00000224287 euGenes: HUgn151507
    ECgene: MSL3P1 H-InvDB: MSL3P1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSL3P1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSL3P1 gene:
    Search GeneIP for patents involving MSL3P1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL3P1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MSL3P1
     Browse SwitchGear Promoter luciferase reporter plasmids for MSL3P1
     Search ThermoFisher Antibodies for MSL3P1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MSL3P1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSL3P1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSL3P1
     Search LSBio for Antibodies for MSL3P1
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     Browse compounds at ApexBio
     Search Addgene for plasmids for MSL3P1
      Search eBioscience for proteins for MSL3P1
      Search eBioscience for elisas for MSL3P1
      eBioscience FlowRNA Probe Sets
           
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