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Aliases for MSL3 Gene

Aliases for MSL3 Gene

  • Male-Specific Lethal 3 Homolog (Drosophila) 2 3 5
  • Male-Specific Lethal-3 Protein-Like 1 3 4
  • MSL3-Like 1 3 4
  • MSL3L1 3 4
  • Male-Specific Lethal-3 (Drosophila)-Like 1 2
  • Male-Specific Lethal 3-Like 1 (Drosophila) 2
  • Male-Specific Lethal-3 Homolog 1 4
  • Male-Specific Lethal 3 Homolog 3

External Ids for MSL3 Gene

Previous HGNC Symbols for MSL3 Gene

  • MSL3L1

Previous GeneCards Identifiers for MSL3 Gene

  • GC0XP011687
  • GC0XP009555

Summaries for MSL3 Gene

Entrez Gene Summary for MSL3 Gene

  • This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]

GeneCards Summary for MSL3 Gene

MSL3 (Male-Specific Lethal 3 Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and methylated histone binding.

UniProtKB/Swiss-Prot for MSL3 Gene

  • May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at Lys-16 which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at Lys-20 (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL3 Gene

Genomics for MSL3 Gene

Regulatory Elements for MSL3 Gene

Enhancers for MSL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG011787 0.8 Ensembl ENCODE 12.9 +29.5 29543 0.6 CTCF ETV1 ZNF143 SMC3 MLLT1 RAD21 MSL3 GC0XM012054 ENSG00000206792
GH0XG011739 0.9 FANTOM5 9.4 -18.1 -18147 0.2 HDAC1 TBP RB1 SIN3A BMI1 ZNF766 EGR1 RELB IKZF2 CREM ARHGAP6 MSL3 LOC105373131 ENSG00000282840
GH0XG011756 1 ENCODE 5.4 +1.1 1119 4.6 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A YY1 ETS1 ZNF766 GLIS2 ZNF143 MSL3 ENSG00000206792 GC0XM012054
GH0XG011340 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -416.2 -416174 2.4 ATF1 ARNT YY1 TCF12 ELK1 GATA2 FOS JUNB TBX21 ZNF592 HCCS MSL3 LOC100422628 GC0XM011637
GH0XG011764 0.8 ENCODE 5.1 +6.8 6785 1.5 HDGF TAL1 YBX1 FEZF1 EBF1 TCF12 GATA2 NCOR1 NR2F6 TRIM24 MSL3 GC0XM012054 ENSG00000206792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MSL3 on UCSC Golden Path with GeneCards custom track

Promoters for MSL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000244468 941 3401 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A YY1 ETS1 ZNF766 GLIS2 ZNF143

Genomic Location for MSL3 Gene

Chromosome:
X
Start:
11,758,159 bp from pter
End:
11,775,753 bp from pter
Size:
17,595 bases
Orientation:
Plus strand

Genomic View for MSL3 Gene

Genes around MSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSL3 Gene

Proteins for MSL3 Gene

  • Protein details for MSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Y2-MS3L1_HUMAN
    Recommended name:
    Male-specific lethal 3 homolog
    Protein Accession:
    Q8N5Y2
    Secondary Accessions:
    • A6NCU2
    • A6NHW8
    • A8K165
    • B4DUV8
    • B7Z227
    • Q9UG70
    • Q9Y5Z8

    Protein attributes for MSL3 Gene

    Size:
    521 amino acids
    Molecular mass:
    59824 Da
    Quaternary structure:
    • Component the MSL histone acetyltransferase complex at least composed of the MOF/KAT8, MSL1/hampin, MSL2 and MSL3. Interacts (via the MRG domain) with MSL1.
    Miscellaneous:
    • MSL3L1 gene undergoes X inactivation.

    Three dimensional structures from OCA and Proteopedia for MSL3 Gene

    Alternative splice isoforms for MSL3 Gene

neXtProt entry for MSL3 Gene

Post-translational modifications for MSL3 Gene

  • Ubiquitination at posLast=289289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MSL3 Gene

Domains & Families for MSL3 Gene

Protein Domains for MSL3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MSL3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MSL3 Gene

Function for MSL3 Gene

Molecular function for MSL3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at Lys-16 which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at Lys-20 (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.

Gene Ontology (GO) - Molecular Function for MSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 20657587
GO:0035064 methylated histone binding IDA 20657587
genes like me logo Genes that share ontologies with MSL3: view
genes like me logo Genes that share phenotypes with MSL3: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSL3 Gene

Localization for MSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSL3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0035267 NuA4 histone acetyltransferase complex IBA --
GO:0072487 MSL complex IDA 20018852
genes like me logo Genes that share ontologies with MSL3: view

Pathways & Interactions for MSL3 Gene

genes like me logo Genes that share pathways with MSL3: view

Pathways by source for MSL3 Gene

Gene Ontology (GO) - Biological Process for MSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006338 chromatin remodeling IBA --
GO:0006342 chromatin silencing IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MSL3: view

No data available for SIGNOR curated interactions for MSL3 Gene

Drugs & Compounds for MSL3 Gene

No Compound Related Data Available

Transcripts for MSL3 Gene

Unigene Clusters for MSL3 Gene

Male-specific lethal 3 homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSL3 Gene

No ASD Table

Relevant External Links for MSL3 Gene

GeneLoc Exon Structure for
MSL3
ECgene alternative splicing isoforms for
MSL3

Expression for MSL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSL3 Gene

mRNA differential expression in normal tissues according to GTEx for MSL3 Gene

This gene is overexpressed in Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for MSL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.4) and Esophagus (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSL3 Gene



Protein tissue co-expression partners for MSL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MSL3 Gene:

MSL3

SOURCE GeneReport for Unigene cluster for MSL3 Gene:

Hs.655288

mRNA Expression by UniProt/SwissProt for MSL3 Gene:

Q8N5Y2-MS3L1_HUMAN
Tissue specificity: Expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart.

Evidence on tissue expression from TISSUES for MSL3 Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MSL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSL3 Gene

Orthologs for MSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MSL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSL3 34 35
  • 99.86 (n)
cow
(Bos Taurus)
Mammalia MSL3 34 35
  • 93.01 (n)
dog
(Canis familiaris)
Mammalia MSL3 34 35
  • 90.47 (n)
oppossum
(Monodelphis domestica)
Mammalia MSL3 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msl3 34 16 35
  • 85.22 (n)
Msl3l2 35
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Msl3 34
  • 85.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MSL3 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSL3 34 35
  • 79 (n)
lizard
(Anolis carolinensis)
Reptilia MSL3 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msl3 34
  • 74.2 (n)
Str.758 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25372 34
fruit fly
(Drosophila melanogaster)
Insecta msl-3 34 35
  • 44.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001917 34
  • 43.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToOne
Species where no ortholog for MSL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MSL3 Gene

ENSEMBL:
Gene Tree for MSL3 (if available)
TreeFam:
Gene Tree for MSL3 (if available)

Paralogs for MSL3 Gene

(1) SIMAP similar genes for MSL3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MSL3: view

No data available for Paralogs for MSL3 Gene

Variants for MSL3 Gene

Sequence variations from dbSNP and Humsavar for MSL3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000173511 -- 11,769,954(+) TTCTT(A/C)CAGAC intron-variant
rs1000204598 -- 11,769,707(+) CAGGC(A/G)ATCCT intron-variant
rs1000213999 -- 11,775,949(+) TGCTG(A/T)CTTGT downstream-variant-500B
rs1000406803 -- 11,761,462(+) AAGTA(C/T)AAAAT intron-variant
rs1000673661 -- 11,761,129(+) GTCAT(A/G)CTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSL3 Gene

Variant ID Type Subtype PubMed ID
nsv1075719 CNV deletion 25765185
nsv524154 CNV gain 19592680
nsv526302 CNV gain 19592680

Variation tolerance for MSL3 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSL3 Gene

Disorders for MSL3 Gene

Relevant External Links for MSL3

Genetic Association Database (GAD)
MSL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSL3

No disorders were found for MSL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSL3 Gene

Publications for MSL3 Gene

  1. Characterization of a novel chromo domain gene in Xp22.3 with homology to Drosophila msl-3. (PMID: 10395802) Prakash S.K. … Zoghbi H.Y. (Genomics 1999) 2 3 4 64
  2. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. (PMID: 21217699) Kadlec J. … Akhtar A. (Nat. Struct. Mol. Biol. 2011) 3 4 64
  3. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y. … Conaway R.C. (J. Biol. Chem. 2010) 3 4 64
  4. Structural and biochemical studies on the chromo-barrel domain of male specific lethal 3 (MSL3) reveal a binding preference for mono- or dimethyllysine 20 on histone H4. (PMID: 20943666) Moore S.A. … Scott M.J. (J. Biol. Chem. 2010) 3 4 64
  5. Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. (PMID: 20657587) Kim D. … Khorasanizadeh S. (Nat. Struct. Mol. Biol. 2010) 3 4 64

Products for MSL3 Gene

  • Addgene plasmids for MSL3

Sources for MSL3 Gene

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