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Aliases for MSL3 Gene

Aliases for MSL3 Gene

  • Male-Specific Lethal 3 Homolog (Drosophila) 2 3
  • Male-Specific Lethal-3 Protein-Like 1 3 4
  • MSL3-Like 1 3 4
  • MSL3L1 3 4
  • Male-Specific Lethal-3 (Drosophila)-Like 1 2
  • Male-Specific Lethal 3-Like 1 (Drosophila) 2
  • Male-Specific Lethal-3 Homolog 1 4

External Ids for MSL3 Gene

Previous HGNC Symbols for MSL3 Gene

  • MSL3L1

Previous GeneCards Identifiers for MSL3 Gene

  • GC0XP011687
  • GC0XP009555

Summaries for MSL3 Gene

Entrez Gene Summary for MSL3 Gene

  • This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]

GeneCards Summary for MSL3 Gene

MSL3 (Male-Specific Lethal 3 Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and methylated histone binding.

UniProtKB/Swiss-Prot for MSL3 Gene

  • May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at Lys-16 which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at Lys-20 (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL3 Gene

Genomics for MSL3 Gene

Regulatory Elements for MSL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MSL3 Gene

Chromosome:
X
Start:
11,758,159 bp from pter
End:
11,775,753 bp from pter
Size:
17,595 bases
Orientation:
Plus strand

Genomic View for MSL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSL3 Gene

Proteins for MSL3 Gene

  • Protein details for MSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Y2-MS3L1_HUMAN
    Recommended name:
    Male-specific lethal 3 homolog
    Protein Accession:
    Q8N5Y2
    Secondary Accessions:
    • A6NCU2
    • A6NHW8
    • A8K165
    • B4DUV8
    • B7Z227
    • Q9UG70
    • Q9Y5Z8

    Protein attributes for MSL3 Gene

    Size:
    521 amino acids
    Molecular mass:
    59824 Da
    Quaternary structure:
    • Component the MSL histone acetyltransferase complex at least composed of the MOF/KAT8, MSL1/hampin, MSL2 and MSL3. Interacts (via the MRG domain) with MSL1.
    Miscellaneous:
    • MSL3L1 gene undergoes X inactivation

    Three dimensional structures from OCA and Proteopedia for MSL3 Gene

    Alternative splice isoforms for MSL3 Gene

neXtProt entry for MSL3 Gene

Proteomics data for MSL3 Gene at MOPED

Post-translational modifications for MSL3 Gene

  • Ubiquitination at Lys 289
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MSL3 Gene

Domains & Families for MSL3 Gene

Protein Domains for MSL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5Y2

UniProtKB/Swiss-Prot:

MS3L1_HUMAN :
  • Contains 1 chromo domain.
Domain:
  • Contains 1 chromo domain.
  • Contains 1 MRG domain.
genes like me logo Genes that share domains with MSL3: view

No data available for Gene Families for MSL3 Gene

Function for MSL3 Gene

Molecular function for MSL3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at Lys-16 which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at Lys-20 (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.

Gene Ontology (GO) - Molecular Function for MSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 20657587
GO:0035064 methylated histone binding IDA 20657587
genes like me logo Genes that share ontologies with MSL3: view
genes like me logo Genes that share phenotypes with MSL3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MSL3 Gene

Localization for MSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSL3 Gene COMPARTMENTS Subcellular localization image for MSL3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0035267 NuA4 histone acetyltransferase complex IBA --
GO:0072487 MSL complex IDA 20018852
genes like me logo Genes that share ontologies with MSL3: view

Pathways & Interactions for MSL3 Gene

genes like me logo Genes that share pathways with MSL3: view

Pathways by source for MSL3 Gene

Gene Ontology (GO) - Biological Process for MSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006338 chromatin remodeling IBA --
GO:0006342 chromatin silencing IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with MSL3: view

No data available for SIGNOR curated interactions for MSL3 Gene

Drugs & Compounds for MSL3 Gene

No Compound Related Data Available

Transcripts for MSL3 Gene

Unigene Clusters for MSL3 Gene

Male-specific lethal 3 homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSL3 Gene

No ASD Table

Relevant External Links for MSL3 Gene

GeneLoc Exon Structure for
MSL3
ECgene alternative splicing isoforms for
MSL3

Expression for MSL3 Gene

mRNA expression in normal human tissues for MSL3 Gene

mRNA differential expression in normal tissues according to GTEx for MSL3 Gene

This gene is overexpressed in Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for MSL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.4) and Esophagus (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSL3 Gene



SOURCE GeneReport for Unigene cluster for MSL3 Gene Hs.655288

mRNA Expression by UniProt/SwissProt for MSL3 Gene

Q8N5Y2-MS3L1_HUMAN
Tissue specificity: Expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart
genes like me logo Genes that share expression patterns with MSL3: view

Protein tissue co-expression partners for MSL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MSL3 Gene

Orthologs for MSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MSL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSL3 35
  • 93.01 (n)
  • 95 (a)
MSL3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSL3 35
  • 90.47 (n)
  • 93.67 (a)
MSL3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msl3 35
  • 85.22 (n)
  • 87.39 (a)
Msl3 16
Msl3 36
  • 86 (a)
OneToMany
Msl3l2 36
  • 65 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MSL3 35
  • 99.86 (n)
  • 99.8 (a)
MSL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msl3 35
  • 85.14 (n)
  • 88.26 (a)
oppossum
(Monodelphis domestica)
Mammalia MSL3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSL3 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSL3 35
  • 79 (n)
  • 84.39 (a)
MSL3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSL3 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msl3 35
  • 74.2 (n)
  • 81.64 (a)
Str.758 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25372 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001917 35
  • 43.85 (n)
  • 36.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta msl-3 35
  • 44.39 (n)
  • 35.29 (a)
msl-3 36
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for MSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MSL3 Gene

ENSEMBL:
Gene Tree for MSL3 (if available)
TreeFam:
Gene Tree for MSL3 (if available)

Paralogs for MSL3 Gene

(1) SIMAP similar genes for MSL3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MSL3: view

No data available for Paralogs for MSL3 Gene

Variants for MSL3 Gene

Sequence variations from dbSNP and Humsavar for MSL3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1051538 -- 11,775,028(+) TATGT(C/T)GCTGC reference, synonymous-codon
rs1051588 -- 11,761,556(+) AAGAA(A/T)GTGAT reference, missense, intron-variant, utr-variant-5-prime
rs1051590 -- 11,762,178(+) GAACA(A/G)TAACT reference, missense
rs1051595 - 11,762,843(+) TAGTG(A/C)AACTT reference, missense
rs1051597 -- 11,762,907(+) TATCA(A/G)TGCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MSL3 Gene

Variant ID Type Subtype PubMed ID
nsv524154 CNV Gain 19592680
nsv526302 CNV Gain 19592680

Variation tolerance for MSL3 Gene

Residual Variation Intolerance Score: 13.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSL3 Gene

HapMap Linkage Disequilibrium report
MSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSL3 Gene

Disorders for MSL3 Gene

Relevant External Links for MSL3

Genetic Association Database (GAD)
MSL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSL3
genes like me logo Genes that share disorders with MSL3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSL3 Gene

Publications for MSL3 Gene

  1. Origin and evolution of the regulatory gene male-specific lethal-3. (PMID: 10908644) MarA-n I. … Baker B.S. (Mol. Biol. Evol. 2000) 2 67
  2. Characterization of a novel chromo domain gene in Xp22.3 with homology to Drosophila msl-3. (PMID: 10395802) Prakash S.K. … Zoghbi H.Y. (Genomics 1999) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb. (PMID: 24837678) Wu L. … Dou Y. (Mol. Cell 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for MSL3 Gene

Sources for MSL3 Gene

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