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MSL3 Gene

protein-coding   GIFtS: 56
GCID: GC0XP011776

Male-Specific Lethal 3 Homolog (Drosophila)

(Previous names: male-specific lethal-3 (Drosophila)-like 1, male-specific...)
(Previous symbol: MSL3L1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Male-Specific Lethal 3 Homolog (Drosophila)1 2     Male-Specific Lethal 3-Like 1 (Drosophila)1
MSL3L11 2 3 5     Male-Specific Lethal-3 (Drosophila)-Like 11
Male-Specific Lethal-3 Protein-Like 12 3     Male-Specific Lethal 3 Homolog2
MSL3-Like 12 3     Male-Specific Lethal-3 Homolog 13

External Ids:    HGNC: 73701   Entrez Gene: 109432   Ensembl: ENSG000000053027   OMIM: 3006095   UniProtKB: Q8N5Y23   

Export aliases for MSL3 gene to outside databases

Previous GC identifers: GC0XP011687 GC0XP009555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSL3 Gene:
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene.
The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene
expression in males and females. Thus, the human protein is thought to play a similar function in chromatin
remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for
histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple
transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. (provided by RefSeq, Jul
2010)

GeneCards Summary for MSL3 Gene:
MSL3 (male-specific lethal 3 homolog (Drosophila)) is a protein-coding gene. Diseases associated with MSL3 include aicardi syndrome, and focal dermal hypoplasia. GO annotations related to this gene include methylated histone residue binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: MS3L1_HUMAN, Q8N5Y2
Function: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X
inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at
'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes
histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in
chromosomal targeting of the MSL complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSL3 gene promoter:
         FOXO4   NF-kappaB1   Pax-4a   NF-kappaB   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MSL3 promoter sequence
   Search Chromatin IP Primers for MSL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.3

MSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSL3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP011776:  view genomic region     (about GC identifiers)

Start:
11,776,278 bp from pter      End:
11,793,872 bp from pter
Size:
17,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MS3L1_HUMAN, Q8N5Y2 (See protein sequence)
Recommended Name: Male-specific lethal 3 homolog  
Size: 521 amino acids; 59824 Da
Subunit: Component the MSL histone acetyltransferase complex at least composed of the MOF/KAT8, MSL1/hampin, MSL2
and MSL3. Interacts (via the MRG domain) with MSL1
Miscellaneous: MSL3L1 gene undergoes X inactivation
3 PDB 3D structures from and Proteopedia for MSL3:
2Y0N (3D)        3OA6 (3D)        3OB9 (3D)    
Secondary accessions: A6NCU2 A6NHW8 A8K165 B4DUV8 Q9UG70 Q9Y5Z8
Alternative splicing: 5 isoforms:  Q8N5Y2-1   Q8N5Y2-2   Q8N5Y2-3   Q8N5Y2-4   Q8N5Y2-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MSL3: NX_Q8N5Y2

Explore proteomics data for MSL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys289
  • Modification sites at PhosphoSitePlus

  • See MSL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001180199.1  NP_001269103.1  NP_006791.2  NP_523352.1  NP_523353.2  

    ENSEMBL proteins: 
     ENSP00000312244   ENSP00000338078   ENSP00000418673   ENSP00000419976   ENSP00000401809  
     ENSP00000370069   ENSP00000370068   ENSP00000370067   ENSP00000381538   ENSP00000354562  
    Reactome Protein details: Q8N5Y2

    MSL3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MSL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR008676 MRG
     IPR000953 Chromo_domain/shadow
     IPR026541 MRG_dom
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot

    Graphical View of Domain Structure for InterPro Entry Q8N5Y2

    ProtoNet protein and cluster: Q8N5Y2

    2 Blocks protein domains:
    IPB000953 Chromo domain
    IPB008676 MRG


    UniProtKB/Swiss-Prot: MS3L1_HUMAN, Q8N5Y2
    Similarity: Contains 1 chromo domain
    Similarity: Contains 1 MRG domain


    MSL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MS3L1_HUMAN, Q8N5Y2
    Function: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X
    inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at
    'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes
    histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in
    chromosomal targeting of the MSL complex

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10395802
    GO:0035064methylated histone residue binding IDA--
         
    MSL3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MSL3:
     Decreased Wnt reporter activit  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSL3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSL3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MSL3:
    hsa-mir-196a-5p (MIRT048163), hsa-mir-16-5p (MIRT051183), hsa-mir-18a-5p (MIRT050657), hsa-mir-26a-5p (MIRT050069), hsa-mir-92a-3p (MIRT049772), hsa-mir-484 (MIRT042164), hsa-let-7f-5p (MIRT051352), hsa-mir-421 (MIRT039372), hsa-mir-10a-5p (MIRT047555), hsa-mir-148a-3p (MIRT048029), hsa-mir-186-5p (MIRT045135), hsa-mir-185-5p (MIRT045319), hsa-mir-10b-5p (MIRT047419)

    Block miRNA regulation of human, mouse, rat MSL3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate MSL3:
    hsa-miR-642a hsa-miR-7-2* hsa-miR-371-5p hsa-miR-888 hsa-miR-373* hsa-miR-7-1* hsa-miR-616* hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidMSL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MSL3
    Predesigned siRNA for gene silencing in human, mouse, rat MSL3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MSL3 (NM_183049)
    Sino Biological Human cDNA Clone for MSL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSL3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MSL3 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MS3L1_HUMAN, Q8N5Y2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10395802
    GO:0005654nucleoplasm TAS--
    GO:0072487MSL complex IDA--

    MSL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MSL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MSL3
        HATs acetylate histones



    MSL3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSL3
    Interactions:

        Search GeneGlobe Interaction Network for MSL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MSL3 (Q8N5Y23 ENSP000003122444) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS10395802
    GO:0007275multicellular organismal development TAS10395802
    GO:0043984histone H4-K16 acetylation IDA--

    MSL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSL3 (MS3L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MSL3 gene (6 alternative transcripts): 
    NM_001193270.2  NM_001282174.1  NM_006800.3  NM_078628.1  NM_078629.3  NM_078630.1  

    Unigene Cluster for MSL3:

    Male-specific lethal 3 homolog (Drosophila)
    Hs.655288  [show with all ESTs]
    Unigene Representative Sequence: NM_078628
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312196(uc004cuw.3 uc011mig.2 uc011mih.2) ENST00000337339(uc004cuv.1)
    ENST00000468149 ENST00000476743 ENST00000421368 ENST00000380693(uc004cuy.3)
    ENST00000380692 ENST00000478462 ENST00000482871 ENST00000473806 ENST00000483645
    ENST00000494268(uc011mii.2) ENST00000380691 ENST00000467141 ENST00000473380
    ENST00000398527 ENST00000361672
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MSL3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate MSL3:
    hsa-miR-642a hsa-miR-7-2* hsa-miR-371-5p hsa-miR-888 hsa-miR-373* hsa-miR-7-1* hsa-miR-616* hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidMSL3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MSL3
    Predesigned siRNA for gene silencing in human, mouse, rat MSL3
    Clone
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    GenScript: all cDNA clones in your preferred vector: MSL3 (NM_183049)
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    Primer
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    OriGene qPCR primer pairs and template standards for MSL3
    OriGene qSTAR qPCR primer pairs in human, mouse for MSL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSL3
      QuantiTect SYBR Green Assays in human, mouse, rat MSL3
      QuantiFast Probe-based Assays in human, mouse, rat MSL3

    Additional mRNA sequence: 

    AF117065.1 AK000793.1 AK025642.1 AK289780.1 AK294255.1 AK300814.1 AK304419.1 AL050178.1 
    AL713667.1 BC010925.1 BC017267.2 BC031210.1 

    16 DOTS entries:

    DT.313852  DT.92031372  DT.100754502  DT.121309585  DT.100736034  DT.91753485  DT.95359496  DT.206741 
    DT.443755  DT.95353270  DT.97842951  DT.100026460  DT.121309583  DT.121309603  DT.40287986  DT.95168923 

    Selected AceView cDNA sequences (see all 187):

    Z46121 BG170948 BE464944 CR609985 BM470848 AI889927 AI203205 AW152465 
    AI240383 AI004790 AW514088 AK000793 CK904697 AA316607 BM977546 BI092020 
    AW451873 BE672317 BM466041 BX460347 AI636687 AI467891 CN484004 BQ946166 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAAGCTCT
    MSL3 Expression
    About this image

    MSL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655288

    UniProtKB/Swiss-Prot: MS3L1_HUMAN, Q8N5Y2
    Tissue specificity: Expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle,
    brain, and placenta, with highest expression in skeletal muscle and heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MSL3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msl31 , 5 male-specific lethal 3 homolog (Drosophila)1, 5 85.22(n)1
    87.39(a)1
      X (78.73 cM)5
    176921  NM_010832.41  NP_034962.21 
     1686541175 
    chicken
    (Gallus gallus)
    Aves MSL31 male-specific lethal 3 homolog (Drosophila) 79(n)
    84.39(a)
      418641  XM_004938399.1  XP_004938456.1 
    lizard
    (Anolis carolinensis)
    Reptilia MSL36
    male-specific lethal 3 homolog (Drosophila)
    81(a)
    1 ↔ 1
    3(119510999-119534859)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253722 Xenopus laevis transcribed sequence with moderate similarity more 76.92(n)    CD303604.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msl-31 male-specific lethal 3 44.39(n)
    35.29(a)
      38779  NM_079227.3  NP_523951.1 


    ENSEMBL Gene Tree for MSL3 (if available)
    TreeFam Gene Tree for MSL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSL3 gene
    1 SIMAP similar gene for MSL3 using alignment to 7 protein entries:     MS3L1_HUMAN (see all proteins):
    MSL3P1

    MSL3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for MSL3
    PGOHUM00000240561 PGOHUM00000240562 PGOHUM00000233013 PGOHUM00000249451 PGOHUM00000249452


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSL3 (see all 299)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928241731,2
    --11689175(+) GGAAAC/GCATCT 2 -- us2k10--------
    rs1420158941,2
    --11689381(+) GAATCA/GTGGTT 3 -- us2k10--------
    rs736326571,2
    C--11689709(+) TTGCAG/AATGAA 3 -- us2k11Minor allele frequency- A:0.00WA 2
    rs1853022291,2
    --11689990(+) CCTAAA/TCCAGT 3 -- us2k10--------
    rs1401277811,2
    C--11690025(+) AAAACG/TCAAAA 3 -- us2k10--------
    rs1504772631,2
    --11690149(+) ATTGAC/TAGCGG 3 -- us2k10--------
    rs734935691,2
    C,F--11690382(+) TCTATG/TCACAG 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1903733731,2
    --11690403(+) CCTTCC/TGCCCT 4 -- us2k10--------
    rs120114941,2
    C,H--11690577(+) CTCCAG/AACCGG 4 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1112300871,2
    C--11690586(+) GGCTCG/TCTCTC 4 -- us2k11Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for MSL3 (11776278 - 11793872 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MSL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524154CNV Gain19592680
    nsv526302CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): MSL3

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300609    OMIM disorders: --

    5 diseases for MSL3:    About MalaCards
    aicardi syndrome    focal dermal hypoplasia    eaf    brain cancer
    malaria

    2 diseases from the University of Copenhagen DISEASES database for MSL3:
    Aicardi syndrome     Focal dermal hypoplasia

    MSL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MSL3

    Export disorders for MSL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSL3 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with MSL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel chromo domain gene in Xp22.3 with homology to Drosophila msl-3. (PubMed id 10395802)1, 2, 3 Prakash S.K....Zoghbi H.Y. (Genomics 1999)
    2. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. (PubMed id 21217699)1, 2 Kadlec J....Akhtar A. (amp 2011)
    3. Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. (PubMed id 20657587)1, 2 Kim D....Khorasanizadeh S. (Nat. Struct. Mol. Biol. 2010)
    4. Structural and biochemical studies on the chromo-barrel domain of male specific lethal 3 (MSL3) reveal a binding preference for mono- or dimethyllysine 20 on histone H4. (PubMed id 20943666)1, 2 Moore S.A.... Scott M.J. (J. Biol. Chem. 2010)
    5. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PubMed id 16227571)1, 2 Smith E.R.... Lucchesi J.C. (Mol. Cell. Biol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Origin and evolution of the regulatory gene male-specific lethal-3. (PubMed id 10908644)1, 3 MarA-n I. and Baker B.S. (Mol. Biol. Evol. 2000)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10943 HGNC: 7370 AceView: MSL3L1 Ensembl:ENSG00000005302 euGenes: HUgn10943
    ECgene: MSL3 H-InvDB: MSL3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MSL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MSL3 gene:
    Search GeneIP for patents involving MSL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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