Aliases for MSL3 Gene
External Ids for MSL3 Gene
Previous HGNC Symbols for MSL3 Gene
Previous GeneCards Identifiers for MSL3 Gene
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
GeneCards Summary for MSL3 Gene
MSL3 (Male-Specific Lethal 3 Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and methylated histone binding.
UniProtKB/Swiss-Prot for MSL3 Gene
May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at Lys-16 which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at Lys-20 (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.