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Aliases for MSL2 Gene

Aliases for MSL2 Gene

  • Male-Specific Lethal 2 Homolog (Drosophila) 2 3
  • Male-Specific Lethal-2 Homolog 1 3 4
  • Male-Specific Lethal 2-Like 1 3 4
  • Ring Finger Protein 184 2 3
  • MSL2-Like 1 3 4
  • MSL2L1 3 4
  • RNF184 3 4
  • MSL-2 3 4
  • Male-Specific Lethal-2 Homolog (Drosophila) 2
  • Male-Specific Lethal 2-Like 1 (Drosophila) 2
  • Male-Specific Lethal-2 Homolog 4
  • RING Finger Protein 184 4
  • EC 6.3.2.- 4
  • KIAA1585 4

External Ids for MSL2 Gene

Previous HGNC Symbols for MSL2 Gene

  • RNF184
  • MSL2L1

Previous GeneCards Identifiers for MSL2 Gene

  • GC03M137353
  • GC03M135867
  • GC03M133245

Summaries for MSL2 Gene

GeneCards Summary for MSL2 Gene

MSL2 (Male-Specific Lethal 2 Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot for MSL2 Gene

  • Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL2 Gene

Genomics for MSL2 Gene

Regulatory Elements for MSL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MSL2 Gene

Chromosome:
3
Start:
136,148,918 bp from pter
End:
136,197,393 bp from pter
Size:
48,476 bases
Orientation:
Minus strand

Genomic View for MSL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSL2 Gene

Proteins for MSL2 Gene

  • Protein details for MSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI7-MSL2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MSL2
    Protein Accession:
    Q9HCI7
    Secondary Accessions:
    • B4DYL4
    • G5E9I1
    • Q0D2P1
    • Q8NDB4
    • Q9NVS4

    Protein attributes for MSL2 Gene

    Size:
    577 amino acids
    Molecular mass:
    62541 Da
    Quaternary structure:
    • Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL1.
    SequenceCaution:
    • Sequence=AAH32719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91673.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13411.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MSL2 Gene

    Alternative splice isoforms for MSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSL2 Gene

Proteomics data for MSL2 Gene at MOPED

Post-translational modifications for MSL2 Gene

  • Ubiquitination at Lys 26
  • Modification sites at PhosphoSitePlus

Other Protein References for MSL2 Gene

No data available for DME Specific Peptides for MSL2 Gene

Domains & Families for MSL2 Gene

Gene Families for MSL2 Gene

Protein Domains for MSL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCI7

UniProtKB/Swiss-Prot:

MSL2_HUMAN :
  • Belongs to the MSL2 family.
  • Contains 1 RING-type zinc finger.
Family:
  • Belongs to the MSL2 family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MSL2: view

Function for MSL2 Gene

Molecular function for MSL2 Gene

UniProtKB/Swiss-Prot Function:
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Enzyme Numbers (IUBMB) for MSL2 Gene

Gene Ontology (GO) - Molecular Function for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with MSL2: view
genes like me logo Genes that share phenotypes with MSL2: view

Animal Model Products

miRNA for MSL2 Gene

miRTarBase miRNAs that target MSL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSL2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MSL2 Gene

Localization for MSL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSL2 Gene COMPARTMENTS Subcellular localization image for MSL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0072487 MSL complex IDA 20018852
genes like me logo Genes that share ontologies with MSL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MSL2 Gene

Pathways & Interactions for MSL2 Gene

genes like me logo Genes that share pathways with MSL2: view

Pathways by source for MSL2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0016567 protein ubiquitination IBA --
GO:0043984 histone H4-K16 acetylation IDA 20018852
genes like me logo Genes that share ontologies with MSL2: view

No data available for SIGNOR curated interactions for MSL2 Gene

Drugs & Compounds for MSL2 Gene

No Compound Related Data Available

Transcripts for MSL2 Gene

Unigene Clusters for MSL2 Gene

Male-specific lethal 2 homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSL2 Gene

No ASD Table

Relevant External Links for MSL2 Gene

GeneLoc Exon Structure for
MSL2
ECgene alternative splicing isoforms for
MSL2

Expression for MSL2 Gene

mRNA expression in normal human tissues for MSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MSL2 Gene

This gene is overexpressed in Breast (37.7), Liver, secretome (17.2), and Cerebrospinal fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSL2 Gene



SOURCE GeneReport for Unigene cluster for MSL2 Gene Hs.18631

genes like me logo Genes that share expression patterns with MSL2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MSL2 Gene

Orthologs for MSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MSL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSL2 35
  • 96.59 (n)
  • 98.79 (a)
MSL2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSL2 35
  • 96.76 (n)
  • 98.96 (a)
MSL2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msl2 35
  • 95.32 (n)
  • 98.96 (a)
Msl2 16
Msl2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MSL2 35
  • 99.77 (n)
  • 100 (a)
MSL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msl2 35
  • 93.24 (n)
  • 98.61 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MSL2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSL2 35
  • 81.86 (n)
  • 83.54 (a)
MSL2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msl2 35
  • 71.98 (n)
  • 71.58 (a)
zebrafish
(Danio rerio)
Actinopterygii msl2b 35
  • 63.6 (n)
  • 63.07 (a)
wufb76c07 35
msl2a 36
  • 50 (a)
OneToMany
msl2b 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta msl-2 36
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for MSL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSL2 Gene

ENSEMBL:
Gene Tree for MSL2 (if available)
TreeFam:
Gene Tree for MSL2 (if available)

Paralogs for MSL2 Gene

No data available for Paralogs for MSL2 Gene

Variants for MSL2 Gene

Sequence variations from dbSNP and Humsavar for MSL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1298135 -- 136,198,954(+) gtgcc(A/C)aaaaa upstream-variant-2KB
rs1829145 -- 136,189,041(-) CCTAA(A/G)AAAAA intron-variant
rs1983070 -- 136,149,362(-) GAAAC(A/G)TGTAT utr-variant-3-prime, downstream-variant-500B
rs1992952 -- 136,194,823(+) CCCTC(A/G)GCAAG upstream-variant-2KB, intron-variant
rs2232005 -- 136,152,247(-) CTTCA(A/C)CTGAA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MSL2 Gene

Variant ID Type Subtype PubMed ID
nsv877518 CNV Loss 21882294
nsv4024 CNV Insertion 18451855

Variation tolerance for MSL2 Gene

Residual Variation Intolerance Score: 14.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSL2 Gene

HapMap Linkage Disequilibrium report
MSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSL2 Gene

Disorders for MSL2 Gene

Relevant External Links for MSL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSL2
genes like me logo Genes that share disorders with MSL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSL2 Gene

Publications for MSL2 Gene

  1. The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA. (PMID: 19941818) Duncan K.E. … Hentze M.W. (Mol. Cell 2009) 23 67
  2. Studies on the short range spreading of the male specific lethal (MSL) complex on the X chromosome in Drosophila. (PMID: 19420929) Sun X. … Birchler J.A. (Cytogenet. Genome Res. 2009) 23 67
  3. Functional domains of Drosophila UNR in translational control. (PMID: 18203923) Abaza I. … Gebauer F. (RNA 2008) 23 67
  4. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PMID: 16543150) Mendjan S. … Akhtar A. (Mol. Cell 2006) 2 67
  5. Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. (PMID: 16452508) Duncan K. … Hentze M.W. (Genes Dev. 2006) 23 67

Products for MSL2 Gene

Sources for MSL2 Gene

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