Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MSL2 Gene

protein-coding   GIFtS: 52
GCID: GC03M135867

Male-Specific Lethal 2 Homolog (Drosophila)

(Previous names: ring finger protein 184, male-specific lethal 2-like 1 (Drosophila))
(Previous symbols: RNF184, MSL2L1)
  See MSL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Male-Specific Lethal 2 Homolog (Drosophila)1 2     MSL2-Like 12 3
RING Finger Protein 1841 2 3     KIAA15853 5
MSL2L11 2 3     Male-Specific Lethal 2-Like 1 (Drosophila)1
RNF1841 2 3     Male-Specific Lethal-2 Homolog (Drosophila)1
Male-Specific Lethal 2-Like 12 3     E3 Ubiquitin-Protein Ligase MSL22
Male-Specific Lethal-2 Homolog 12 3     EC 6.3.2.-3
MSL-22 3     Male-Specific Lethal-2 Homolog3

External Ids:    HGNC: 255441   Entrez Gene: 551672   Ensembl: ENSG000001745797   OMIM: 6148025   UniProtKB: Q9HCI73   

Export aliases for MSL2 gene to outside databases

Previous GC identifers: GC03M137353 GC03M133245


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MSL2 Gene:
MSL2 (male-specific lethal 2 homolog (Drosophila)) is a protein-coding gene. Diseases associated with MSL2 include focal dermal hypoplasia, and aicardi syndrome. GO annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot: MSL2_HUMAN, Q9HCI7
Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at
lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin
ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity
is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation
at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSL2 gene promoter:
         HEN1   E2F-3a   Sox5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSL2 promoter sequence
   Search Chromatin IP Primers for MSL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.2

MSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M135867:  view genomic region     (about GC identifiers)

Start:
135,867,760 bp from pter      End:
135,916,083 bp from pter
Size:
48,324 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MSL2_HUMAN, Q9HCI7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MSL2  
Size: 577 amino acids; 62541 Da
Subunit: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the
KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL1
Sequence caution: Sequence=AAH32719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA91673.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB13411.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for MSL2:
4B7Y (3D)        4B86 (3D)    
Secondary accessions: B4DYL4 G5E9I1 Q0D2P1 Q8NDB4 Q9NVS4
Alternative splicing: 2 isoforms:  Q9HCI7-1   Q9HCI7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MSL2: NX_Q9HCI7

Explore proteomics data for MSL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys26
  • Modification sites at PhosphoSitePlus

  • See MSL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138889.1  NP_060603.2  

    ENSEMBL proteins: 
     ENSP00000311827   ENSP00000387948   ENSP00000418752   ENSP00000417956   ENSP00000418655  
    Reactome Protein details: Q9HCI7

    MSL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MSL2
    OriGene Protein Over-expression Lysate for MSL2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MSL2
    GenScript Custom Purified and Recombinant Proteins Services for MSL2
    Novus Biologicals MSL2 Proteins
    Novus Biologicals MSL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MSL2

     
    Search eBioscience for Proteins for MSL2 

    MSL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MSL2
    Novus Biologicals MSL2 Antibodies
    Search for Antibodies for MSL2 at Abcam
    Cloud-Clone Corp. Antibodies for MSL2
    Search ThermoFisher Antibodies for MSL2
    LSBio Antibodies in human, mouse, rat for MSL2

    MSL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MSL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MSL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MSL2
    Cloud-Clone Corp. CLIAs for MSL2
    Search eBioscience for ELISAs for MSL2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    1 InterPro protein domain:
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q9HCI7

    ProtoNet protein and cluster: Q9HCI7

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: MSL2_HUMAN, Q9HCI7
    Similarity: Belongs to the MSL2 family
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with MSL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSL2_HUMAN, Q9HCI7
    Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at
    lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin
    ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity
    is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation
    at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with MSL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MSL2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MSL2:
    hsa-mir-30d-5p (MIRT047821), hsa-mir-30a-5p (MIRT049962)

    Block miRNA regulation of human, mouse, rat MSL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSL2 (see all 52):
    hsa-miR-429 hsa-miR-300 hsa-miR-1245 hsa-miR-3653 hsa-miR-138-2* hsa-miR-449a hsa-miR-218 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidMSL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MSL2
    Predesigned siRNA for gene silencing in human, mouse, rat MSL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MSL2

    Clone
    Products:
         
    OriGene clones in human, mouse for MSL2 (see all 12)
    OriGene ORF clones in mouse, rat for MSL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MSL2 (NM_018133)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSL2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MSL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MSL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0072487MSL complex IDA--

    Find genes that share ontologies with MSL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MSL2 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with MSL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MSL2
        HATs acetylate histones


        Pathway & Disease-focused RT2 Profiler PCR Array including MSL2: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MSL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for MSL2 (Q9HCI73 ENSP000003118274) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    KAT8Q9H7Z63, ENSP000004060374I2D: score=2 STRING: ENSP00000406037
    MSL3Q8N5Y23, ENSP000003122444I2D: score=1 STRING: ENSP00000312244
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0043984histone H4-K16 acetylation IDA--

    Find genes that share ontologies with MSL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MSL2 gene (2 alternative transcripts): 
    NM_001145417.1  NM_018133.3  

    Unigene Cluster for MSL2:

    Male-specific lethal 2 homolog (Drosophila)
    Hs.18631  [show with all ESTs]
    Unigene Representative Sequence: NM_018133
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309993(uc011bmb.1 uc003eqx.1) ENST00000434835 ENST00000481989
    ENST00000491050 ENST00000473093
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MSL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSL2 (see all 52):
    hsa-miR-429 hsa-miR-300 hsa-miR-1245 hsa-miR-3653 hsa-miR-138-2* hsa-miR-449a hsa-miR-218 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidMSL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MSL2
    Predesigned siRNA for gene silencing in human, mouse, rat MSL2
    Clone
    Products:
         
    OriGene clones in human, mouse for MSL2 (see all 12)
    OriGene ORF clones in mouse, rat for MSL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MSL2 (NM_018133)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSL2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MSL2
    OriGene qSTAR qPCR primer pairs in human, mouse for MSL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSL2
      QuantiTect SYBR Green Assays in human, mouse, rat MSL2
      QuantiFast Probe-based Assays in human, mouse, rat MSL2

    Additional mRNA sequence: 

    AB046805.1 AK001408.1 AK091956.1 AK292557.1 AK302491.1 AL834289.1 BC032719.1 BC093764.1 
    BC093790.1 

    6 DOTS entries:

    DT.207631  DT.95195057  DT.95182094  DT.120869970  DT.92059998  DT.95374179 

    Selected AceView cDNA sequences (see all 78):

    BG260377 AW275928 BQ638800 BM833630 AW083065 NM_018133 AW103169 AL834289 
    BM832428 AB046805 AI659400 CA446514 BU194765 AA775444 AU127632 AA359048 
    AW237818 AJ711374 CA335714 BE867392 CD102242 BF374080 BG394027 AW275942 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MSL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGAAAC
    MSL2 Expression
    About this image


    MSL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
    MSL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18631
        Pathway & Disease-focused RT2 Profiler PCR Array including MSL2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MSL2
    OriGene qSTAR qPCR primer pairs in human, mouse for MSL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSL2
    QuantiTect SYBR Green Assays in human, mouse, rat MSL2
    QuantiFast Probe-based Assays in human, mouse, rat MSL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MSL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msl21 , 5 male-specific lethal 2 homolog (Drosophila)1, 5 95.32(n)1
    98.96(a)1
      9 (53.17 cM)5
    778531  NM_001100451.21  NP_001093921.11 
     1010747275 
    chicken
    (Gallus gallus)
    Aves MSL21 male-specific lethal 2 homolog (Drosophila) 81.86(n)
    83.54(a)
      429119  XM_426675.3  XP_426675.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia BX847191.12   -- 78.81(n)    BX847191.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb76c072 wufb76c07 74.97(n)   322901  CD596223.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msl-26
    male-specific lethal 2
    17(a)
    1 ↔ 1
    2L(3462213-3466111)


    ENSEMBL Gene Tree for MSL2 (if available)
    TreeFam Gene Tree for MSL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MSL2 (see all 1086)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs746161811,2
    C,F--135867362(+) TAAAAG/CGAATT 2 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1476449221,2
    --135867365(+) AAGGAA/CTTCTT 2 -- ds50010--------
    rs1806944151,2
    --135867401(+) CTCCCA/GGAAAT 2 -- ds50010--------
    rs1849191501,2
    --135868190(+) CAAACG/TTTAGG 2 -- ut310--------
    rs19830701,2
    C,H--135868204(-) GAAACA/GTGTAT 2 -- ut31 ese317Minor allele frequency- G:0.00NS EA NA WA CSA 793
    rs1893491311,2
    --135868276(+) AGACAA/GGACAA 2 -- ut310--------
    rs345983431,2
    C--135868370(+) TGGAC-/ACAT  
            
    ACATC
    2 -- ut311Minor allele frequency- ACAT:0.00NA 2
    rs1122981411,2
    C--135868374(+) CACATA/C/TCATCA 4 -- ut311CSA 1
    rs2013323591,2
    C--135868402(+) CTTTAG/TCCCAC 2 -- ut310--------
    rs1125222441,2
    C--135868455(+) AAGCCCAA/-CAACA 2 -- cds11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for MSL2 (135867760 - 135916083 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MSL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4024CNV Insertion18451855
    nsv877518CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSL2
    DNA2.0 Custom Variant and Variant Library Synthesis for MSL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614802    OMIM disorders: --

    2 diseases for MSL2:    
    About MalaCards
    focal dermal hypoplasia    aicardi syndrome

    2 diseases from the University of Copenhagen DISEASES database for MSL2:
    Aicardi syndrome     Focal dermal hypoplasia

    Find genes that share disorders with MSL2           About GenesLikeMe


    Export disorders for MSL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MSL2 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with MSL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PubMed id 16227571)1, 2, 3 Smith E.R.... Lucchesi J.C. (Mol. Cell. Biol. 2005)
    2. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. (PubMed id 23084835)1, 2 Hallacli E....Kadlec J. (Mol. Cell 2012)
    3. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. (PubMed id 21726816)1, 2 Wu L.... Dou Y. (Mol. Cell 2011)
    4. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PubMed id 16543150)1, 3 Mendjan S.... Akhtar A. (Mol. Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Msl2 is a novel component of the vertebrate DNA damage response. (PubMed id 23874665)1 Lai Z....Rea S. (PLoS ONE 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. (PubMed id 23969696)1 Sabater-Lleal M....O'Donnell C.J. (Circulation 2013)
    10. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55167 HGNC: 25544 AceView: FLJ10546 Ensembl:ENSG00000174579 euGenes: HUgn55167
    ECgene: MSL2 H-InvDB: MSL2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1585

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MSL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MSL2 gene:
    Search GeneIP for patents involving MSL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MSL2  
     OriGene qPCR primer pairs and template standards for MSL2   OriGene Protein Over-expression Lysate for MSL2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MSL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MSL2   OriGene Purified Protein for MSL2  
     OriGene ORF clones in mouse, rat for MSL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MSL2   OriGene Custom Protein Services for MSL2  

     
     
     Block miRNA regulation of human, mouse, rat MSL2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MSL2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSL2 Predesigned siRNA for gene silencing in human, mouse, rat MSL2
     QuantiFast Probe-based Assays in human, mouse, rat MSL2 QuantiTect SYBR Green Assays in human, mouse, rat MSL2
     PCR Arrays including human, mouse, rat MSL2 Search Chromatin IP Primers for MSL2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSL2  Search GeneGlobe Interaction Network for MSL2
     Regulatory tfbs in MSL2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MSL2 GenScript cDNA clones with any tag delivered in your preferred vector for MSL2
     GenScript Custom Assay Services for MSL2 GenScript Custom overexpressing Cell Line Services for MSL2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MSL2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MSL2 antibodies
     MSL2 proteins
     MSL2 lysates
     Search for Antibodies for MSL2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MSL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MSL2
     Antibodies for MSL2
     ELISAs for MSL2
     CLIAs for MSL2



     Browse ESI BIO Cell Lines and PureStem Progenitors for MSL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL2
     SwitchGear 3'UTR luciferase reporter plasmids for MSL2
     SwitchGear Promoter luciferase reporter plasmids for MSL2
     Search ThermoFisher Antibodies for MSL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSL2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSL2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSL2
     LSBio Antibodies in human, mouse, rat for MSL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MSL2
      Search eBioscience for proteins for MSL2
      Search eBioscience for elisas for MSL2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MSL2 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4