Aliases for MSL2 Gene
External Ids for MSL2 Gene
Previous HGNC Symbols for MSL2 Gene
Previous GeneCards Identifiers for MSL2 Gene
GeneCards Summary for MSL2 Gene
MSL2 (Male-Specific Lethal 2 Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with MSL2 include focal dermal hypoplasia and aicardi syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include ligase activity.
UniProtKB/Swiss-Prot for MSL2 Gene
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.