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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSL2 Gene

protein-coding   GIFtS: 48
GCID: GC03M135867

Male-Specific Lethal 2 Homolog (Drosophila)

(Previous names: ring finger protein 184, male-specific lethal 2-like 1 (Drosophila))
(Previous symbols: RNF184, MSL2L1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Male-Specific Lethal 2 Homolog (Drosophila)1 2     MSL2-Like 12 3
RING Finger Protein 1841 2 3     Male-Specific Lethal 2-Like 1 (Drosophila)1
MSL2L11 2 3     Male-Specific Lethal-2 Homolog (Drosophila)1
RNF1841 2 3     E3 Ubiquitin-Protein Ligase MSL22
Male-Specific Lethal 2-Like 12 3     EC 6.3.2.-3
Male-Specific Lethal-2 Homolog 12 3     KIAA15853
MSL-22 3     Male-Specific Lethal-2 Homolog3

External Ids:    HGNC: 255441   Entrez Gene: 551672   Ensembl: ENSG000001745797   OMIM: 6148025   UniProtKB: Q9HCI73   

Export aliases for MSL2 gene to outside databases

Previous GC identifers: GC03M137353 GC03M133245


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MSL2 Gene: 
MSL2 (male-specific lethal 2 homolog (Drosophila)) is a protein-coding gene. Diseases associated with MSL2 include focal dermal hypoplasia, and aicardi syndrome. GO annotations related to this gene include zinc ion binding and ligase activity.

UniProtKB/Swiss-Prot: MSL2_HUMAN, Q9HCI7
Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at
lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin
ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity
is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation
at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSL2 gene promoter:
         HEN1   E2F-3a   Sox5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.2

MSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M135867:  view genomic region     (about GC identifiers)

Start:
135,867,760 bp from pter      End:
135,916,083 bp from pter
Size:
48,324 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MSL2_HUMAN, Q9HCI7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase MSL2  
Size: 577 amino acids; 62541 Da
Subunit: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the
KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3
Sequence caution: Sequence=AAH32719.1; Type=Erroneous initiation; Sequence=BAA91673.1; Type=Erroneous initiation;
Sequence=BAB13411.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for MSL2:
4B7Y (3D)        4B86 (3D)    
Secondary accessions: B4DYL4 G5E9I1 Q0D2P1 Q8NDB4 Q9NVS4
Alternative splicing: 2 isoforms:  Q9HCI7-1   Q9HCI7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MSL2: NX_Q9HCI7

Explore proteomics data for MSL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCI7

  • MSL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MSL2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138889.1  NP_060603.2  

    ENSEMBL proteins: 
     ENSP00000311827   ENSP00000387948   ENSP00000418752   ENSP00000417956   ENSP00000418655  

    Human Recombinant Protein Products for MSL2: 
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    Novus Biologicals MSL2 Proteins
    Novus Biologicals MSL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MSL2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0072487MSL complex IDA--

    MSL2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for MSL2 
    Cloud-Clone Corp. CLIAs for MSL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    1 InterPro protein domain:
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q9HCI7

    ProtoNet protein and cluster: Q9HCI7

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: MSL2_HUMAN, Q9HCI7
    Similarity: Belongs to the MSL2 family
    Similarity: Contains 1 RING-type zinc finger


    MSL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSL2_HUMAN, Q9HCI7
    Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at
    lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin
    ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity
    is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation
    at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    MSL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MSL2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MSL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MSL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSL2 
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    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate MSL2 (see all 52):
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    SwitchGear 3'UTR luciferase reporter plasmidMSL2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/22 Interacting proteins for MSL2 (Q9HCI73 ENSP000003118274) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    KAT8Q9H7Z63, ENSP000004060374I2D: score=2 STRING: ENSP00000406037
    MSL3Q8N5Y23, ENSP000003122444I2D: score=1 STRING: ENSP00000312244
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043984histone H4-K16 acetylation IDA--

    MSL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSL2

    Search CenterWatch for drugs/clinical trials and news about MSL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSL2 gene (2 alternative transcripts): 
    NM_001145417.1  NM_018133.3  

    Unigene Cluster for MSL2:

    Male-specific lethal 2 homolog (Drosophila)
    Hs.18631  [show with all ESTs]
    Unigene Representative Sequence: NM_018133
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309993(uc011bmb.1 uc003eqx.1) ENST00000434835 ENST00000481989
    ENST00000491050 ENST00000473093
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSL2
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate MSL2 (see all 52):
    hsa-miR-429 hsa-miR-300 hsa-miR-1245 hsa-miR-3653 hsa-miR-138-2* hsa-miR-449a hsa-miR-218 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidMSL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSL2
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    GenScript: all cDNA clones in your preferred vector (see all 2): MSL2 (NM_018133)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSL2
    Sirion Biotech Customized lentivirus for stable overexpression of MSL2 
                         Customized lentivirus expression plasmids for stable overexpression of MSL2 
    Primer
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    OriGene qPCR primer pairs and template standards for MSL2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSL2

    Additional mRNA sequence: 

    AB046805.1 AK001408.1 AK091956.1 AK292557.1 AK302491.1 AL834289.1 BC032719.1 BC093764.1 
    BC093790.1 

    6 DOTS entries:

    DT.207631  DT.95195057  DT.95182094  DT.120869970  DT.92059998  DT.95374179 

    24/78 AceView cDNA sequences (see all 78):

    CA446514 AW275928 AW103169 NM_018133 BM832428 AW083065 BQ638800 BU194765 
    AL834289 BM833630 AI659400 BG260377 AB046805 BM471472 AW237818 BX111095 
    AJ711374 AU136838 AW083098 AK091956 AW401732 BE867392 CA335714 CD102242 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSL2 expression in normal human tissues (normalized intensities)      MSL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGAAAC
    MSL2 Expression
    About this image


    MSL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Double Negative 2 Thymocytes Thymus
             leukocytes   
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus

    See MSL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSL2

    SOURCE GeneReport for Unigene cluster: Hs.18631
        SABiosciences Expression via Pathway-Focused PCR Array including MSL2: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MSL2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msl21 , 5 male-specific lethal 2 homolog (Drosophila)1, 5 95.32(n)1
    98.96(a)1
      9 (53.17 cM)5
    778531  NM_001100451.11  NP_001093921.11 
     1010747275 
    chicken
    (Gallus gallus)
    Aves MSL21 male-specific lethal 2 homolog (Drosophila) 81.86(n)
    83.54(a)
      429119  XM_426675.2  XP_426675.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia BX847191.12   -- 78.81(n)    BX847191.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb76c072 wufb76c07 74.97(n)   322901  CD596223.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msl-26
    male-specific lethal 2
    14(a)
    1 ↔ 1
    2L(3462213-3466111)


    ENSEMBL Gene Tree for MSL2 (if available)
    TreeFam Gene Tree for MSL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1086 SNPs in MSL2 are shown (see all 1086)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs746161811,2
    C,F--135867362(+) TAAAAG/CGAATT 2 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1476449221,2
    --135867365(+) AAGGAA/CTTCTT 2 -- ds50010--------
    rs1806944151,2
    --135867401(+) CTCCCA/GGAAAT 2 -- ds50010--------
    rs1849191501,2
    --135868190(+) CAAACG/TTTAGG 2 -- ut310--------
    rs19830701,2
    C,H--135868204(-) GAAACA/GTGTAT 2 -- ut31 ese317Minor allele frequency- G:0.00NS EA NA WA CSA 793
    rs1893491311,2
    --135868276(+) AGACAA/GGACAA 2 -- ut310--------
    rs345983431,2
    C--135868370(+) TGGAC-/ACAT  
            
    ACATC
    2 -- ut311Minor allele frequency- ACAT:0.00NA 2
    rs1122981411,2
    C--135868374(+) CACATA/C/TCATCA 4 -- ut311CSA 1
    rs2013323591,2
    C--135868402(+) CTTTAG/TCCCAC 2 -- ut310--------
    rs1125222441,2
    C--135868455(+) AAGCCCAA/-CAACA 2 -- cds11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for MSL2 (135867760 - 135916083 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MSL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4024CNV Insertion18451855
    nsv877518CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MSL2
    DNA2.0 Custom Variant and Variant Library Synthesis for MSL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614802    OMIM disorders: --

    3 diseases for MSL2:    About MalaCards
    focal dermal hypoplasia    aicardi syndrome    colorectal cancer

    2 diseases from the University of Copenhagen DISEASES database for MSL2:
    Aicardi syndrome     Focal dermal hypoplasia

    MSL2 for disorders           About GeneDecksing


    Export disorders for MSL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSL2 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with MSL2)
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    1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PubMed id 16227571)1, 2, 3 Smith E.R.... Lucchesi J.C. (2005)
    2. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K7 9 methylation. (PubMed id 21726816)1, 2 Wu L....Dou Y. (2011)
    3. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PubMed id 16543150)1, 3 Mendjan S....Akhtar A. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    6. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    7. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)
    8. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. (PubMed id 23084835)1 Hallacli E....Kadlec J. (2012)
    9. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    10. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55167 HGNC: 25544 AceView: FLJ10546 Ensembl:ENSG00000174579 euGenes: HUgn55167
    ECgene: MSL2 H-InvDB: MSL2

    (According to HUGE)
    About This Section
    HUGE: KIAA1585

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSL2 gene:
    Search GeneIP for patents involving MSL2

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