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Aliases for MSL2 Gene

Aliases for MSL2 Gene

  • Male-Specific Lethal 2 Homolog (Drosophila) 2 3 5
  • Male-Specific Lethal-2 Homolog 1 3 4
  • Male-Specific Lethal 2-Like 1 3 4
  • Ring Finger Protein 184 2 3
  • MSL2-Like 1 3 4
  • MSL2L1 3 4
  • RNF184 3 4
  • MSL-2 3 4
  • Male-Specific Lethal-2 Homolog (Drosophila) 2
  • Male-Specific Lethal 2-Like 1 (Drosophila) 2
  • E3 Ubiquitin-Protein Ligase MSL2 3
  • Male-Specific Lethal-2 Homolog 4
  • RING Finger Protein 184 4
  • EC 6.3.2.- 4
  • KIAA1585 4

External Ids for MSL2 Gene

Previous HGNC Symbols for MSL2 Gene

  • RNF184
  • MSL2L1

Previous GeneCards Identifiers for MSL2 Gene

  • GC03M137353
  • GC03M135867
  • GC03M133245

Summaries for MSL2 Gene

GeneCards Summary for MSL2 Gene

MSL2 (Male-Specific Lethal 2 Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot for MSL2 Gene

  • Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL2 Gene

Genomics for MSL2 Gene

Regulatory Elements for MSL2 Gene

Enhancers for MSL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F136191 1.2 ENCODE 16.4 +2.4 2378 7.1 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 PCCB MSL2 NCK1 IL20RB NCK1-AS1 GC03P136156
GH03F136248 1.1 ENCODE 13.4 -52.8 -52806 4.2 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 IL20RB MSL2 NCK1 STAG1 PCCB RPL31P23
GH03F136748 1.1 ENCODE 13.2 -554.4 -554444 6.2 PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B FEZF1 DMAP1 ZNF2 YY1 IL20RB ENSG00000261758 SLC35G2 MSL2 NCK1 STAG1 ENSG00000242968 ENSG00000273486 PCCB LOC100421438
GH03F136802 1.2 Ensembl ENCODE 10.9 -605.5 -605455 0.9 PKNOX1 ZNF133 FEZF1 GLI4 ZNF2 GLIS2 ZNF302 ZNF416 ZNF263 JUNB LINC01210 MSL2 IL20RB-AS1 NCK1 STAG1 IL20RB ENSG00000242968 GC03M136767
GH03F136929 0.6 ENCODE 14 -733.2 -733175 1.9 TAF1 MAX USF2 CEBPB CEBPG ZNF664 RAD51 CEBPA ZNF548 NCK1-AS1 STAG1 MSL2 NCK1 ENSG00000273486 IL20RB RAD51AP1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MSL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MSL2 Gene

Chromosome:
3
Start:
136,148,918 bp from pter
End:
136,197,393 bp from pter
Size:
48,476 bases
Orientation:
Minus strand

Genomic View for MSL2 Gene

Genes around MSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSL2 Gene

Proteins for MSL2 Gene

  • Protein details for MSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI7-MSL2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase MSL2
    Protein Accession:
    Q9HCI7
    Secondary Accessions:
    • B4DYL4
    • G5E9I1
    • Q0D2P1
    • Q8NDB4
    • Q9NVS4

    Protein attributes for MSL2 Gene

    Size:
    577 amino acids
    Molecular mass:
    62541 Da
    Quaternary structure:
    • Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL1.
    SequenceCaution:
    • Sequence=AAH32719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91673.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13411.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MSL2 Gene

    Alternative splice isoforms for MSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSL2 Gene

Post-translational modifications for MSL2 Gene

  • Ubiquitination at Lys 26
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MSL2 Gene

Domains & Families for MSL2 Gene

Gene Families for MSL2 Gene

Suggested Antigen Peptide Sequences for MSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCI7

UniProtKB/Swiss-Prot:

MSL2_HUMAN :
  • Belongs to the MSL2 family.
  • Contains 1 RING-type zinc finger.
Family:
  • Belongs to the MSL2 family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MSL2: view

Function for MSL2 Gene

Molecular function for MSL2 Gene

UniProtKB/Swiss-Prot Function:
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.

Enzyme Numbers (IUBMB) for MSL2 Gene

Gene Ontology (GO) - Molecular Function for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA,IBA --
genes like me logo Genes that share ontologies with MSL2: view
genes like me logo Genes that share phenotypes with MSL2: view

Animal Model Products

miRNA for MSL2 Gene

miRTarBase miRNAs that target MSL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSL2 Gene

Localization for MSL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSL2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0072487 MSL complex IDA 20018852
genes like me logo Genes that share ontologies with MSL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MSL2 Gene

Pathways & Interactions for MSL2 Gene

genes like me logo Genes that share pathways with MSL2: view

Pathways by source for MSL2 Gene

Gene Ontology (GO) - Biological Process for MSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043984 histone H4-K16 acetylation IDA 20018852
genes like me logo Genes that share ontologies with MSL2: view

No data available for SIGNOR curated interactions for MSL2 Gene

Transcripts for MSL2 Gene

Unigene Clusters for MSL2 Gene

Male-specific lethal 2 homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSL2 Gene

No ASD Table

Relevant External Links for MSL2 Gene

GeneLoc Exon Structure for
MSL2
ECgene alternative splicing isoforms for
MSL2

Expression for MSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MSL2 Gene

This gene is overexpressed in Breast (37.7), Liver, secretome (17.2), and Cerebrospinal fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MSL2 Gene:

MSL2

SOURCE GeneReport for Unigene cluster for MSL2 Gene:

Hs.18631
genes like me logo Genes that share expression patterns with MSL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MSL2 Gene

Orthologs for MSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSL2 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia MSL2 34 35
  • 96.76 (n)
cow
(Bos Taurus)
Mammalia MSL2 34 35
  • 96.59 (n)
mouse
(Mus musculus)
Mammalia Msl2 34 16 35
  • 95.32 (n)
rat
(Rattus norvegicus)
Mammalia Msl2 34
  • 93.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MSL2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSL2 34 35
  • 81.86 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia msl2 34
  • 71.98 (n)
zebrafish
(Danio rerio)
Actinopterygii msl2b 34 35
  • 63.6 (n)
msl2a 35
  • 50 (a)
OneToMany
wufb76c07 34
fruit fly
(Drosophila melanogaster)
Insecta msl-2 35
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for MSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSL2 Gene

ENSEMBL:
Gene Tree for MSL2 (if available)
TreeFam:
Gene Tree for MSL2 (if available)

Paralogs for MSL2 Gene

No data available for Paralogs for MSL2 Gene

Variants for MSL2 Gene

Sequence variations from dbSNP and Humsavar for MSL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10222451 -- 136,158,571(+) ctgct(C/G)ttgcc intron-variant
rs10541204 -- 136,178,763(+) CTCCT(-/CCT)GACCT intron-variant
rs10570676 -- 136,178,758(+) TCGAA(-/CTC)CTCCT intron-variant
rs10571267 -- 136,185,302(+) AAGCT(-/AA)AAAAA intron-variant
rs10684427 -- 136,190,557(+) AAAAA(-/A)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSL2 Gene

Variant ID Type Subtype PubMed ID
nsv967069 CNV duplication 23825009
nsv955351 CNV duplication 24416366
nsv4024 CNV insertion 18451855

Variation tolerance for MSL2 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSL2 Gene

Disorders for MSL2 Gene

Relevant External Links for MSL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSL2

No disorders were found for MSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSL2 Gene

Publications for MSL2 Gene

  1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PMID: 16227571) Smith E.R. … Lucchesi J.C. (Mol. Cell. Biol. 2005) 2 3 4 64
  2. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. (PMID: 23084835) Hallacli E. … Kadlec J. (Mol. Cell 2012) 3 4 64
  3. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. (PMID: 21726816) Wu L. … Dou Y. (Mol. Cell 2011) 3 4 64
  4. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PMID: 16543150) Mendjan S. … Akhtar A. (Mol. Cell 2006) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for MSL2 Gene

Sources for MSL2 Gene

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