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Aliases for MSL1 Gene

Aliases for MSL1 Gene

  • Male Specific Lethal 1 Homolog 2 3 5
  • Male-Specific Lethal-1 Homolog 1 3 4
  • Male-Specific Lethal 1-Like 1 3 4
  • MSL1-Like 1 3 4
  • MSL-1 3 4
  • Male-Specific Lethal 1 Homolog (Drosophila) 2
  • Male-Specific Lethal 1 Homolog 3
  • MSL1L1 4
  • HMSL1 3

External Ids for MSL1 Gene

Previous GeneCards Identifiers for MSL1 Gene

  • GC17P035533
  • GC17P038278
  • GC17P034072

Summaries for MSL1 Gene

GeneCards Summary for MSL1 Gene

MSL1 (Male Specific Lethal 1 Homolog) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for MSL1 Gene

  • Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub). This modification in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL1 Gene

Genomics for MSL1 Gene

Regulatory Elements for MSL1 Gene

Enhancers for MSL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G040102 2.1 FANTOM5 Ensembl ENCODE dbSUPER 27.4 -12.5 -12522 13.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MSL1 ENSG00000266469 MED1 CDK12 CASC3 THRA MED24 CDC6 ENSG00000266208 RARA
GH17G040088 2 FANTOM5 Ensembl ENCODE dbSUPER 25 -26.6 -26641 14.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 MSL1 MED1 ENSG00000266469 MED24 GSDMA CDK12 THRA ENSG00000266208 RARA PGAP3
GH17G040329 1.6 FANTOM5 ENCODE dbSUPER 28.9 +209.6 209627 3.9 HDGF PKNOX1 SIN3A ZNF48 YY1 GLIS2 ZNF143 ZNF207 REST TBX21 RARA MSL1 ENSG00000266208 WIPF2 KRTAP4-6 CASC3 LOC105371934 RARA-AS1
GH17G040306 1.9 FANTOM5 ENCODE dbSUPER 22.8 +195.5 195538 22.8 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 MED1 ENSG00000266469 SNORD124 CDK12 RARA MSL1 TMEM99 CDC6 WIPF2 PGAP3
GH17G040061 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 17.9 -52.7 -52693 14.8 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1 MED24 GSDMA MSL1 RAPGEFL1 PSMD3 MED1 TCAP ORMDL3 THRA GSDMB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MSL1 on UCSC Golden Path with GeneCards custom track

Promoters for MSL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094035 912 3801 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2

Genomic Location for MSL1 Gene

Chromosome:
17
Start:
40,121,988 bp from pter
End:
40,136,916 bp from pter
Size:
14,929 bases
Orientation:
Plus strand

Genomic View for MSL1 Gene

Genes around MSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSL1 Gene

Proteins for MSL1 Gene

  • Protein details for MSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DK7-MSL1_HUMAN
    Recommended name:
    Male-specific lethal 1 homolog
    Protein Accession:
    Q68DK7
    Secondary Accessions:
    • Q0VF46
    • Q69Z03

    Protein attributes for MSL1 Gene

    Size:
    614 amino acids
    Molecular mass:
    67128 Da
    Quaternary structure:
    • Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL2. Interacts with KAT8 and MSL3; both interactions are direct. Directly interacts with NUPR1. Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity.

    Three dimensional structures from OCA and Proteopedia for MSL1 Gene

    Alternative splice isoforms for MSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSL1 Gene

Post-translational modifications for MSL1 Gene

No data available for DME Specific Peptides for MSL1 Gene

Domains & Families for MSL1 Gene

Protein Domains for MSL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68DK7

UniProtKB/Swiss-Prot:

MSL1_HUMAN :
  • The coiled coil is formed by helices from two subunits in the MSL1 homodimer.
  • Belongs to the msl-1 family.
Domain:
  • The coiled coil is formed by helices from two subunits in the MSL1 homodimer.
Family:
  • Belongs to the msl-1 family.
genes like me logo Genes that share domains with MSL1: view

No data available for Gene Families for MSL1 Gene

Function for MSL1 Gene

Molecular function for MSL1 Gene

UniProtKB/Swiss-Prot Function:
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub). This modification in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by gamma-irradiation.
genes like me logo Genes that share phenotypes with MSL1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MSL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSL1 Gene

Localization for MSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSL1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0072487 MSL complex IDA,IEA 20018852
genes like me logo Genes that share ontologies with MSL1: view

Pathways & Interactions for MSL1 Gene

genes like me logo Genes that share pathways with MSL1: view

Pathways by source for MSL1 Gene

Gene Ontology (GO) - Biological Process for MSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016569 covalent chromatin modification IEA --
GO:0043984 histone H4-K16 acetylation IEA,IDA 20018852
genes like me logo Genes that share ontologies with MSL1: view

No data available for SIGNOR curated interactions for MSL1 Gene

Drugs & Compounds for MSL1 Gene

No Compound Related Data Available

Transcripts for MSL1 Gene

Unigene Clusters for MSL1 Gene

Male-specific lethal 1 homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MSL1

Alternative Splicing Database (ASD) splice patterns (SP) for MSL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for MSL1 Gene

GeneLoc Exon Structure for
MSL1
ECgene alternative splicing isoforms for
MSL1

Expression for MSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSL1 Gene

mRNA differential expression in normal tissues according to GTEx for MSL1 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for MSL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (42.9) and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSL1 Gene



Protein tissue co-expression partners for MSL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MSL1 Gene:

MSL1

SOURCE GeneReport for Unigene cluster for MSL1 Gene:

Hs.532786

Evidence on tissue expression from TISSUES for MSL1 Gene

  • Liver(4.3)
  • Nervous system(4)
  • Eye(3.4)
  • Lung(2.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with MSL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSL1 Gene

Orthologs for MSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSL1 34 35
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia MSL1 34 35
  • 98.29 (n)
cow
(Bos Taurus)
Mammalia MSL1 34 35
  • 97.72 (n)
mouse
(Mus musculus)
Mammalia Msl1 34 16 35
  • 95.44 (n)
rat
(Rattus norvegicus)
Mammalia Msl1 34
  • 95.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MSL1 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSL1 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSL1 34 35
  • 76.73 (n)
lizard
(Anolis carolinensis)
Reptilia MSL1 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msl1 34
  • 65 (n)
Str.19052 34
African clawed frog
(Xenopus laevis)
Amphibia MGC54001 34
zebrafish
(Danio rerio)
Actinopterygii MSL1 (2 of 2) 35
  • 34 (a)
OneToMany
MSL1 (1 of 2) 35
  • 29 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7887 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
CSA.5925 35
  • 14 (a)
OneToMany
Species where no ortholog for MSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSL1 Gene

ENSEMBL:
Gene Tree for MSL1 (if available)
TreeFam:
Gene Tree for MSL1 (if available)

Paralogs for MSL1 Gene

No data available for Paralogs for MSL1 Gene

Variants for MSL1 Gene

Sequence variations from dbSNP and Humsavar for MSL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000004266 -- 40,132,883(+) GATTC(G/T)GTTAC intron-variant
rs1000010481 -- 40,121,793(+) ACCCC(A/G)CTCCT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000210652 -- 40,130,830(+) TTAAG(A/G)GAAAC intron-variant
rs1000819970 -- 40,122,264(+) AGACG(A/G)GGCGG upstream-variant-2KB, utr-variant-5-prime
rs1000877987 -- 40,121,575(+) GGGCC(A/G)CCCGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MSL1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv528369 CNV loss 19592680
nsv833444 CNV loss 17160897

Variation tolerance for MSL1 Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSL1 Gene

Disorders for MSL1 Gene

Relevant External Links for MSL1

Genetic Association Database (GAD)
MSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSL1

No disorders were found for MSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSL1 Gene

Publications for MSL1 Gene

  1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PMID: 16227571) Smith E.R. … Lucchesi J.C. (Mol. Cell. Biol. 2005) 2 3 4 64
  2. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. (PMID: 23084835) Hallacli E. … Kadlec J. (Mol. Cell 2012) 3 4 64
  3. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. (PMID: 21217699) Kadlec J. … Akhtar A. (Nat. Struct. Mol. Biol. 2011) 3 4 64
  4. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. (PMID: 21726816) Wu L. … Dou Y. (Mol. Cell 2011) 3 4 64
  5. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. (PMID: 19650074) Gironella M. … Iovanna J.L. (J. Cell. Physiol. 2009) 3 4 64

Products for MSL1 Gene

  • Addgene plasmids for MSL1

Sources for MSL1 Gene

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