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Aliases for MSL1 Gene

Aliases for MSL1 Gene

  • Male Specific Lethal 1 Homolog 2 3
  • Male-Specific Lethal 1 Homolog (Drosophila) 2 5
  • Male-Specific Lethal-1 Homolog 1 3 4
  • Male-Specific Lethal 1-Like 1 3 4
  • MSL1-Like 1 3 4
  • MSL-1 3 4
  • MSL1L1 4
  • HMSL1 3

External Ids for MSL1 Gene

Previous GeneCards Identifiers for MSL1 Gene

  • GC17P035533
  • GC17P038278
  • GC17P034072

Summaries for MSL1 Gene

GeneCards Summary for MSL1 Gene

MSL1 (Male Specific Lethal 1 Homolog) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for MSL1 Gene

  • Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub). This modification in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL1 Gene

Genomics for MSL1 Gene

Regulatory Elements for MSL1 Gene

Promoters for MSL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MSL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MSL1 Gene

Chromosome:
17
Start:
40,121,988 bp from pter
End:
40,136,916 bp from pter
Size:
14,929 bases
Orientation:
Plus strand

Genomic View for MSL1 Gene

Genes around MSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSL1 Gene

Proteins for MSL1 Gene

  • Protein details for MSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DK7-MSL1_HUMAN
    Recommended name:
    Male-specific lethal 1 homolog
    Protein Accession:
    Q68DK7
    Secondary Accessions:
    • Q0VF46
    • Q69Z03

    Protein attributes for MSL1 Gene

    Size:
    614 amino acids
    Molecular mass:
    67128 Da
    Quaternary structure:
    • Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL2. Interacts with KAT8 and MSL3; both interactions are direct. Directly interacts with NUPR1. Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity.

    Three dimensional structures from OCA and Proteopedia for MSL1 Gene

    Alternative splice isoforms for MSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSL1 Gene

Proteomics data for MSL1 Gene at MOPED

Post-translational modifications for MSL1 Gene

Other Protein References for MSL1 Gene

No data available for DME Specific Peptides for MSL1 Gene

Domains & Families for MSL1 Gene

Protein Domains for MSL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68DK7

UniProtKB/Swiss-Prot:

MSL1_HUMAN :
  • The coiled coil is formed by helices from two subunits in the MSL1 homodimer.
  • Belongs to the msl-1 family.
Domain:
  • The coiled coil is formed by helices from two subunits in the MSL1 homodimer.
Family:
  • Belongs to the msl-1 family.
genes like me logo Genes that share domains with MSL1: view

No data available for Gene Families for MSL1 Gene

Function for MSL1 Gene

Molecular function for MSL1 Gene

UniProtKB/Swiss-Prot Function:
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub). This modification in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by gamma-irradiation.
genes like me logo Genes that share phenotypes with MSL1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSL1 Gene

Localization for MSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSL1 Gene COMPARTMENTS Subcellular localization image for MSL1 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for MSL1 Gene

Pathways & Interactions for MSL1 Gene

genes like me logo Genes that share pathways with MSL1: view

Pathways by source for MSL1 Gene

Gene Ontology (GO) - Biological Process for MSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043984 histone H4-K16 acetylation IEA,IDA 20018852
genes like me logo Genes that share ontologies with MSL1: view

No data available for SIGNOR curated interactions for MSL1 Gene

Drugs & Compounds for MSL1 Gene

No Compound Related Data Available

Transcripts for MSL1 Gene

Unigene Clusters for MSL1 Gene

Male-specific lethal 1 homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for MSL1 Gene

GeneLoc Exon Structure for
MSL1
ECgene alternative splicing isoforms for
MSL1

Expression for MSL1 Gene

mRNA expression in normal human tissues for MSL1 Gene

mRNA differential expression in normal tissues according to GTEx for MSL1 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for MSL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (42.9) and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSL1 Gene



SOURCE GeneReport for Unigene cluster for MSL1 Gene Hs.532786

genes like me logo Genes that share expression patterns with MSL1: view

Protein tissue co-expression partners for MSL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MSL1 Gene

Orthologs for MSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSL1 35
  • 97.72 (n)
  • 98.86 (a)
MSL1 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSL1 35
  • 98.29 (n)
  • 99.43 (a)
MSL1 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msl1 35
  • 95.44 (n)
  • 95.44 (a)
Msl1 16
Msl1 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MSL1 35
  • 99.91 (n)
  • 100 (a)
MSL1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msl1 35
  • 95.22 (n)
  • 95.82 (a)
oppossum
(Monodelphis domestica)
Mammalia MSL1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSL1 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSL1 35
  • 76.73 (n)
  • 81.48 (a)
MSL1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSL1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msl1 35
  • 65 (n)
  • 65.62 (a)
Str.19052 35
African clawed frog
(Xenopus laevis)
Amphibia MGC54001 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7887 35
zebrafish
(Danio rerio)
Actinopterygii MSL1 (1 of 2) 36
  • 29 (a)
OneToMany
MSL1 (2 of 2) 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
CSA.5925 36
  • 14 (a)
OneToMany
Species with no ortholog for MSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSL1 Gene

ENSEMBL:
Gene Tree for MSL1 (if available)
TreeFam:
Gene Tree for MSL1 (if available)

Paralogs for MSL1 Gene

No data available for Paralogs for MSL1 Gene

Variants for MSL1 Gene

Sequence variations from dbSNP and Humsavar for MSL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12773 -- 40,122,921(+) TTGCC(A/C)TGTCC intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs2030379 -- 40,125,881(-) ATGGC(A/G)TGGTC intron-variant
rs2030380 -- 40,125,453(-) ACAAC(A/G)GCAAA intron-variant
rs1043812 -- 40,136,805(+) TCTGC(A/T)TCAAT downstream-variant-500B
rs2293006 -- 40,123,281(-) ATCTG(C/T)TTGAG intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MSL1 Gene

Variant ID Type Subtype PubMed ID
nsv908221 CNV Loss 21882294
nsv833444 CNV Loss 17160897
nsv528369 CNV Loss 19592680

Variation tolerance for MSL1 Gene

Residual Variation Intolerance Score: 22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSL1 Gene

HapMap Linkage Disequilibrium report
MSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSL1 Gene

Disorders for MSL1 Gene

Relevant External Links for MSL1

Genetic Association Database (GAD)
MSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSL1

No disorders were found for MSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MSL1 Gene

Publications for MSL1 Gene

  1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PMID: 16227571) Smith E.R. … Lucchesi J.C. (Mol. Cell. Biol. 2005) 2 3 4 67
  2. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PMID: 16543150) Mendjan S. … Akhtar A. (Mol. Cell 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb. (PMID: 24837678) Wu L. … Dou Y. (Mol. Cell 2014) 3
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3

Products for MSL1 Gene

Sources for MSL1 Gene

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