Aliases for MSL1 Gene
External Ids for MSL1 Gene
GeneCards Summary for MSL1 Gene
UniProtKB/Swiss-Prot for MSL1 Gene
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub). This modification in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.