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Aliases for MSL1 Gene

Aliases for MSL1 Gene

  • Male-Specific Lethal 1 Homolog (Drosophila) 2 3
  • Male-Specific Lethal-1 Homolog 1 3 4
  • Male-Specific Lethal 1-Like 1 3 4
  • MSL1-Like 1 3 4
  • MSL-1 3 4
  • Male-Specific Lethal 1 Homolog 3
  • MSL1L1 4
  • HMSL1 3

External Ids for MSL1 Gene

Summaries for MSL1 Gene

GeneCards Summary for MSL1 Gene

MSL1 (Male-Specific Lethal 1 Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

UniProtKB/Swiss-Prot for MSL1 Gene

  • Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub). This modification in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSL1 Gene

Genomics for MSL1 Gene

Genomic Location for MSL1 Gene

Start:
40,121,983 bp from pter
End:
40,136,916 bp from pter
Size:
14,934 bases
Orientation:
Plus strand

Genomic View for MSL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSL1 Gene

Regulatory Elements for MSL1 Gene

Proteins for MSL1 Gene

  • Protein details for MSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DK7-MSL1_HUMAN
    Recommended name:
    Male-specific lethal 1 homolog
    Protein Accession:
    Q68DK7
    Secondary Accessions:
    • Q0VF46
    • Q69Z03

    Protein attributes for MSL1 Gene

    Size:
    614 amino acids
    Molecular mass:
    67128 Da
    Quaternary structure:
    • Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL2. Interacts with KAT8 and MSL3; both interactions are direct. Directly interacts with NUPR1. Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity.

    Three dimensional structures from OCA and Proteopedia for MSL1 Gene

    Alternative splice isoforms for MSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSL1 Gene

Proteomics data for MSL1 Gene at MOPED

Post-translational modifications for MSL1 Gene

Other Protein References for MSL1 Gene

No data available for DME Specific Peptides for MSL1 Gene

Domains for MSL1 Gene

Protein Domains for MSL1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MSL1_HUMAN
Domain:
  • The coiled coil is formed by helices from two subunits in the MSL1 homodimer:
    • Q68DK7
Family:
  • Belongs to the msl-1 family.:
    • Q68DK7
genes like me logo Genes that share domains with MSL1: view

No data available for Gene Families for MSL1 Gene

Function for MSL1 Gene

Molecular function for MSL1 Gene

UniProtKB/Swiss-Prot Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at Lys-16 (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at Lys-34 (H2BK34Ub). This modification in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
UniProtKB/Swiss-Prot Induction: Up-regulated by gamma-irradiation.

Phenotypes for MSL1 Gene

genes like me logo Genes that share phenotypes with MSL1: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MSL1 Gene

Localization for MSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSL1 Gene COMPARTMENTS Subcellular localization image for MSL1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0072487 MSL complex IDA 20018852
genes like me logo Genes that share ontologies with MSL1: view

Pathways for MSL1 Gene

genes like me logo Genes that share pathways with MSL1: view

Pathways by source for MSL1 Gene

Gene Ontology (GO) - Biological Process for MSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0043984 histone H4-K16 acetylation IDA 20018852
genes like me logo Genes that share ontologies with MSL1: view

Transcripts for MSL1 Gene

Unigene Clusters for MSL1 Gene

Male-specific lethal 1 homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for MSL1 Gene

GeneLoc Exon Structure for
MSL1
ECgene alternative splicing isoforms for
MSL1

Expression for MSL1 Gene

mRNA expression in normal human tissues for MSL1 Gene

mRNA differential expression in normal tissues according to GTEx for MSL1 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSL1 Gene

SOURCE GeneReport for Unigene cluster for MSL1 Gene Hs.532786

genes like me logo Genes that share expressions with MSL1: view

Orthologs for MSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSL1 36
  • 99.91 (n)
  • 100 (a)
MSL1 37
  • 57 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSL1 36
  • 97.72 (n)
  • 98.86 (a)
MSL1 37
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSL1 36
  • 98.29 (n)
  • 99.43 (a)
MSL1 37
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msl1 36
  • 95.44 (n)
  • 95.44 (a)
Msl1 16
Msl1 37
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSL1 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSL1 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msl1 36
  • 95.22 (n)
  • 95.82 (a)
chicken
(Gallus gallus)
Aves MSL1 36
  • 76.73 (n)
  • 81.48 (a)
MSL1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSL1 37
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC54001 36
tropical clawed frog
(Silurana tropicalis)
Amphibia msl1 36
  • 65 (n)
  • 65.62 (a)
Str.19052 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7887 36
zebrafish
(Danio rerio)
Actinopterygii MSL1 (1 of 2) 37
  • 29 (a)
OneToMany
MSL1 (2 of 2) 37
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
CSA.5925 37
  • 14 (a)
OneToMany
Species with no ortholog for MSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSL1 Gene

ENSEMBL:
Gene Tree for MSL1 (if available)
TreeFam:
Gene Tree for MSL1 (if available)

Paralogs for MSL1 Gene

No data available for Paralogs for MSL1 Gene

Variants for MSL1 Gene

Sequence variations from dbSNP and Humsavar for MSL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12773 -- 40,122,921(+) TTGCC(A/C)TGTCC intron-variant, synonymous-codon, reference
rs1043812 -- 40,136,805(+) TCTGC(A/T)TCAAT downstream-variant-500B
rs2030379 -- 40,125,881(-) ATGGC(A/G)TGGTC intron-variant
rs2030380 -- 40,125,453(-) ACAAC(A/G)GCAAA intron-variant
rs2293006 -- 40,123,281(-) ATCTG(C/T)TTGAG intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MSL1 Gene

Variant ID Type Subtype PubMed ID
nsv908221 CNV Loss 21882294
nsv833444 CNV Loss 17160897
nsv528369 CNV Loss 19592680

Relevant External Links for MSL1 Gene

HapMap Linkage Disequilibrium report
MSL1

Disorders for MSL1 Gene

Relevant External Links for MSL1

Genetic Association Database (GAD)
MSL1
genes like me logo Genes that share disorders with MSL1: view

No data available for UniProtKB/Swiss-Prot for MSL1 Gene

Publications for MSL1 Gene

  1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PMID: 16227571) Smith E.R. … Lucchesi J.C. (Mol. Cell. Biol. 2005) 2 3 4
  2. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PMID: 16543150) Mendjan S. … Akhtar A. (Mol. Cell 2006) 2 3
  3. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. (PMID: 19650074) Gironella M. … Iovanna J.L. (J. Cell. Physiol. 2009) 3 4
  4. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. (PMID: 21217699) Kadlec J. … Akhtar A. (Nat. Struct. Mol. Biol. 2011) 3 4
  5. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. (PMID: 21726816) Wu L. … Dou Y. (Mol. Cell 2011) 3 4

Products for MSL1 Gene

Sources for MSL1 Gene

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