Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MSL1 Gene

protein-coding   GIFtS: 48
GCID: GC17P038278

Male-Specific Lethal 1 Homolog (Drosophila)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Male-Specific Lethal 1 Homolog (Drosophila)1 2     MSL1-Like 12 3
Male-Specific Lethal 1-Like 12 3     hMSL12
Male-Specific Lethal-1 Homolog 12 3     Male-Specific Lethal 1 Homolog2
MSL-12 3     MSL1L13

External Ids:    HGNC: 279051   Entrez Gene: 3392872   Ensembl: ENSG000001888957   OMIM: 6148015   UniProtKB: Q68DK73   

Export aliases for MSL1 gene to outside databases

Previous GC identifers: GC17P035533 GC17P034072


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MSL1 Gene:
MSL1 (male-specific lethal 1 homolog (Drosophila)) is a protein-coding gene.

UniProtKB/Swiss-Prot: MSL1_HUMAN, Q68DK7
Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at
'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances
MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This
modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to
gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and
KAT8 together for enzymatic activity regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSL1 gene promoter:
         Pax-2   Olf-1   Pax-2a   POU6F1 (c2)   CBF-C   CBF-A   CBF-B   HOXA5   CP1A   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MSL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q21.1

MSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038278:  view genomic region     (about GC identifiers)

Start:
38,278,551 bp from pter      End:
38,293,042 bp from pter
Size:
14,492 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MSL1_HUMAN, Q68DK7 (See protein sequence)
Recommended Name: Male-specific lethal 1 homolog  
Size: 614 amino acids; 67128 Da
Subunit: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the
KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL2. Interacts with KAT8 and
MSL3; both interactions are direct. Directly interacts with NUPR1. Interacts with TP53BP1; this interaction may
be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity
3 PDB 3D structures from and Proteopedia for MSL1:
4B7Y (3D)        4B86 (3D)        4DNC (3D)    
Secondary accessions: Q0VF46 Q69Z03
Alternative splicing: 3 isoforms:  Q68DK7-1   Q68DK7-2   Q68DK7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MSL1: NX_Q68DK7

Explore proteomics data for MSL1 at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MSL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012241.1  
    ENSEMBL proteins: 
     ENSP00000381543   ENSP00000463949   ENSP00000462731   ENSP00000462945   ENSP00000462114  
     ENSP00000462915  
    Reactome Protein details: Q68DK7

    MSL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MSL1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MSL1
    GenScript Custom Purified and Recombinant Proteins Services for MSL1
    Novus Biologicals MSL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MSL1

     
    Search eBioscience for Proteins for MSL1 

     
    antibodies-online proteins for MSL1 

     
    antibodies-online peptides for MSL1

    MSL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MSL1
    Novus Biologicals MSL1 Antibodies
    Abcam antibodies for MSL1
    Cloud-Clone Corp. Antibodies for MSL1
    Search ThermoFisher Antibodies for MSL1
    antibodies-online antibodies for MSL1 (12 products) 

    MSL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MSL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MSL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MSL1
    Cloud-Clone Corp. CLIAs for MSL1
    Search eBioscience for ELISAs for MSL1 
    antibodies-online kits for MSL1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR026711 Msl-1

    Graphical View of Domain Structure for InterPro Entry Q68DK7

    ProtoNet protein and cluster: Q68DK7

    UniProtKB/Swiss-Prot: MSL1_HUMAN, Q68DK7
    Domain: The coiled coil is formed by helices from two subunits in the MSL1 homodimer
    Similarity: Belongs to the msl-1 family


    Find genes that share domains with MSL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSL1_HUMAN, Q68DK7
    Function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at
    'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances
    MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This
    modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to
    gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and
    KAT8 together for enzymatic activity regulation
    Induction: Up-regulated by gamma-irradiation

    Phenotypes:
         1 GenomeRNAi human phenotype for MSL1:

     Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MSL1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MSL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSL1 (see all 80):
    hsa-miR-520e hsa-miR-3194-5p hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-128 hsa-miR-138-2* hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MSL1
    Predesigned siRNA for gene silencing in human, mouse, rat MSL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MSL1

    Clone
    Products:
         
    OriGene clones in human, mouse for MSL1 (see all 7)
    OriGene ORF clones in mouse, rat for MSL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSL1 (NM_001012241)
    Sino Biological Human cDNA Clone for MSL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSL1
    Addgene plasmids for MSL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MSL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MSL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MSL1_HUMAN, Q68DK7: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0072487MSL complex IDA--

    Find genes that share ontologies with MSL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MSL1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with MSL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MSL1
        HATs acetylate histones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSL1
    Interactions:

        Search GeneGlobe Interaction Network for MSL1

    Selected Interacting proteins for MSL1 (Q68DK73) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT8Q9H7Z63I2D: score=2 
    CADPSQ9ULU83I2D: score=1 
    CRKLP461093I2D: score=1 
    FCHSD2O948683I2D: score=1 
    MSL2Q9HCI73I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0043984histone H4-K16 acetylation IDA--

    Find genes that share ontologies with MSL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MSL1 gene: 
    NM_001012241.1  

    Unigene Cluster for MSL1:

    Male-specific lethal 1 homolog (Drosophila)
    Hs.532786  [show with all ESTs]
    Unigene Representative Sequence: NM_001012241
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398532 ENST00000577454(uc002huc.2) ENST00000578648 ENST00000579565
    ENST00000578826 ENST00000582920 ENST00000582884 ENST00000581246 ENST00000339569(uc002hua.4 uc002hub.3 uc002hud.3)
    ENST00000583127 ENST00000580086
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MSL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSL1 (see all 80):
    hsa-miR-520e hsa-miR-3194-5p hsa-miR-15a hsa-miR-106a hsa-miR-200a hsa-miR-128 hsa-miR-138-2* hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MSL1
    Predesigned siRNA for gene silencing in human, mouse, rat MSL1
    Clone
    Products:
         
    OriGene clones in human, mouse for MSL1 (see all 7)
    OriGene ORF clones in mouse, rat for MSL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSL1 (NM_001012241)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSL1
    Addgene plasmids for MSL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MSL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MSL1
      QuantiTect SYBR Green Assays in human, mouse, rat MSL1
      QuantiFast Probe-based Assays in human, mouse, rat MSL1

    Additional mRNA sequence: 

    AK055378.1 AK297619.1 AL049450.1 BC019821.1 BC039449.1 BC118997.1 BC122543.1 BX647188.1 
    CR749360.1 

    15 DOTS entries:

    DT.446206  DT.97844982  DT.452373  DT.95172218  DT.40132087  DT.97791312  DT.97844132  DT.120981538 
    DT.95191094  DT.95189979  DT.100784851  DT.100784852  DT.100706124  DT.120981547  DT.430352 

    Selected AceView cDNA sequences (see all 522):

    CA447821 CA307817 CA450093 BI917709 BM931396 BM989342 BC019821 W60310 
    BQ694736 AI272836 BM547318 BQ186859 AA693383 AA058546 AA394266 W92652 
    BM475963 BQ004676 AI336348 BE896063 AI241569 AA344221 BQ014717 AI346936 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MSL1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                                        
    SP2:        -                                                               
    SP3:                                                  -                     
    SP4:                                                                        


    ECgene alternative splicing isoforms for MSL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATACAACA
    MSL1 Expression
    About this image

    MSL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532786
        Custom PCR Arrays for MSL1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MSL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MSL1
    QuantiTect SYBR Green Assays in human, mouse, rat MSL1
    QuantiFast Probe-based Assays in human, mouse, rat MSL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for MSL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msl11 , 5 male-specific lethal 1 homolog (Drosophila)1, 5 95.44(n)1
    95.44(a)1
      11 (62.67 cM)5
    740261  NM_028722.21  NP_082998.21 
     987955165 
    chicken
    (Gallus gallus)
    Aves MSL11 male-specific lethal 1 homolog (Drosophila) 76.73(n)
    81.48(a)
      777194  XM_001236663.3  XP_001236664.3 
    lizard
    (Anolis carolinensis)
    Reptilia MSL16
    male-specific lethal 1 homolog (Drosophila)
    53(a)
    1 ↔ 1
    6(69400603-69415614)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC540012 similar to MLN51 protein 76.37(n)    BC047246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ555546.12   -- 76.47(n)    AJ555546.1 


    ENSEMBL Gene Tree for MSL1 (if available)
    TreeFam Gene Tree for MSL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MSL1 (see all 287)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413052361,2
    --38276845(+) ACAAAG/TCACAG 1 -- us2k10--------
    rs1450384371,2
    C--38276894(+) AATGTC/TAGTCT 1 -- us2k10--------
    rs755531801,2
    C,F--38276896(+) TGTCAG/ATCTTC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1813446601,2
    --38276908(+) CCATCA/TCCATA 1 -- us2k10--------
    rs1868281951,2
    --38276910(+) ATCTCA/CATAGA 1 -- us2k10--------
    rs1483058221,2
    --38277088(+) TCTCTA/CCTAAA 1 -- us2k10--------
    rs1916109091,2
    --38277175(+) TGAACC/TCCGGA 1 -- us2k10--------
    rs1404375851,2
    --38277240(+) AGTGAA/GAATCC 1 -- us2k10--------
    rs1838611261,2
    --38277293(+) GACTTG/TTTGGC 1 -- us2k10--------
    rs1504935521,2
    --38277338(+) AGCTGA/GAGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MSL1 (38278551 - 38293042 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MSL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908221CNV Loss21882294
    nsv528369CNV Loss19592680
    nsv833444CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSL1
    DNA2.0 Custom Variant and Variant Library Synthesis for MSL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614801    OMIM disorders: --


    Find genes that share disorders with MSL1           About GenesLikeMe

    Genetic Association Database (GAD): MSL1

    Export disorders for MSL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MSL1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with MSL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PubMed id 16227571)1, 2, 3 Smith E.R.... Lucchesi J.C. (Mol. Cell. Biol. 2005)
    2. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. (PubMed id 23084835)1, 2 Hallacli E....Kadlec J. (Mol. Cell 2012)
    3. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. (PubMed id 21217699)1, 2 Kadlec J....Akhtar A. (amp 2011)
    4. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. (PubMed id 21726816)1, 2 Wu L.... Dou Y. (Mol. Cell 2011)
    5. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. (PubMed id 19650074)1, 2 Gironella M....Iovanna J.L. (J. Cell. Physiol. 2009)
    6. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PubMed id 16543150)1, 3 Mendjan S.... Akhtar A. (Mol. Cell 2006)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    9. Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. (PubMed id 22547026)2 Huang J.... Lei M. (Cell Res. 2012)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 339287 HGNC: 27905 AceView: LOC339287 Ensembl:ENSG00000188895 euGenes: HUgn339287
    ECgene: MSL1 H-InvDB: MSL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MSL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MSL1 gene:
    Search GeneIP for patents involving MSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MSL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MSL1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MSL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MSL1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MSL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MSL1   OriGene Custom Protein Services for MSL1  

     
     
     Block miRNA regulation of human, mouse, rat MSL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MSL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSL1 Predesigned siRNA for gene silencing in human, mouse, rat MSL1
     QuantiFast Probe-based Assays in human, mouse, rat MSL1 QuantiTect SYBR Green Assays in human, mouse, rat MSL1
     Custom PCR Arrays for MSL1 Search Chromatin IP Primers for MSL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MSL1  Search GeneGlobe Interaction Network for MSL1
     Regulatory tfbs in MSL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MSL1 GenScript cDNA clones with any tag delivered in your preferred vector for MSL1
     GenScript Custom Assay Services for MSL1 GenScript Custom overexpressing Cell Line Services for MSL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MSL1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MSL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MSL1 antibodies
     MSL1 lysates
     Antibodies for MSL1
     See all of Abcam's Antibodies, Kits and Proteins for MSL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MSL1
     Antibodies for MSL1
     ELISAs for MSL1
     CLIAs for MSL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for MSL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSL1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MSL1
     Browse SwitchGear Promoter luciferase reporter plasmids for MSL1
     Search ThermoFisher Antibodies for MSL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSL1
     Browse compounds at ApexBio
     Addgene plasmids for MSL1
      Search eBioscience for proteins for MSL1
      Search eBioscience for elisas for MSL1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MSL1
     antibodies-online antibodies for MSL1 (12 products)
     antibodies-online kits for MSL1 (4 products)
     antibodies-online peptides for MSL1
     antibodies-online proteins for MSL1
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MSL1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4