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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSI2 Gene

protein-coding   GIFtS: 60
GCID: GC17P055334

musashi RNA-binding protein 2

(Previous name: musashi homolog 2 (Drosophila) )
 Explore 12 diseases affiliated with
MSI2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MSI2    

Aliases
for MSI2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Musashi RNA-Binding Protein 21 2     Musashi-23
Musashi Homolog 2 (Drosophila)1     RNA-Binding Protein Musashi Homolog 22
MSI2H2     Musashi-23
Musashi Homolog 22     

External Ids:    HGNC: 185851   Entrez Gene: 1245402   Ensembl: ENSG000001539447   OMIM: 6078975   UniProtKB: Q96DH63   

Export aliases for MSI2 gene to outside databases

Previous GC identifers: GC17P055073 GC17P057815 GC17P055676 GC17P055808 GC17P052688 GC17P050694


Summaries
for MSI2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MSI2:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species
function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript
variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role
in the proliferation and maintenance of stem cells in the central nervous system (By similarity)




Genomic Views
for MSI2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSI2 gene promoter:
         AREB6   PPAR-alpha   S8   Chx10   Nkx2-5   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MSI2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

MSI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSI2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P055334:  view genomic region     (about GC identifiers)

Start:
 55,333,212 bp from pter      End:
 55,762,046 bp from pter
Size:
 428,835 bases      Orientation:
 plus strand

Proteins
for MSI2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6 (See protein sequence)
Recommended Name: RNA-binding protein Musashi homolog 2  
Size: 328 amino acids; 35197 Da
Subcellular location: Cytoplasm. Note=Associated with polysomes (By similarity)
Secondary accessions: Q7Z6M7 Q8N9T4
Alternative splicing: 3 isoforms:  Q96DH6-1   Q96DH6-2   Q96DH6-3   (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. Contains a phosphoserine at position 14)

Explore the universe of human proteins at neXtProt for MSI2: NX_Q96DH6

Post-translational modifications:

  • Phosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96DH6

    • MSI2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_620412.1  NP_733839.1  

    ENSEMBL proteins: 
     ENSP00000414671   ENSP00000284073   ENSP00000463227   ENSP00000313616   ENSP00000462914  
     ENSP00000392607   ENSP00000462264  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): MSI2
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    Novus Biologicals MSI2 Proteins
    Novus Biologicals MSI2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MSI2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--


    MSI2 for ontologies           About GeneDecksing



    MSI2 Antibody Products: 
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    R&D Systems Antibodies for MSI2 (Musashi-2)
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    ThermoFisher Antibody for MSI2

    Assay Products for MSI2: 
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    Uscn ELISAs and CLIAs for MSI2

    Protein Domains /
    Families
    for MSI2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MSI2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q96DH6

    ProtoNet protein and cluster: Q96DH6

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
    Similarity: Belongs to the Musashi family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for MSI2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
    Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role
    in the proliferation and maintenance of stem cells in the central nervous system (By similarity)
    Induction: Up-regulated in astrocytes after brain injury (By similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target MSI2:
    hsa-mir-155 (MIRT001533)

    OriGene 3'-UTR Clone (see all 2): MSI2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSI2
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MSI2 (see all 19):
    hsa-miR-320a hsa-miR-485-5p hsa-miR-218-2* hsa-miR-431 hsa-miR-29b-1* hsa-miR-550a* hsa-miR-10b* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmid: MSI2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSI2
    OriGene shRNA RFP: MSI2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSI2

    Gene Editing
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MSI2 (NM_170721)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSI2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MSI2
    Search LifeMap BioReagents cell lines for MSI2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSI2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0008266poly(U) RNA binding IEA--


    MSI2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MSI2:
     Decreased viability of wild-ty  Increased G1 DNA content 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Msi2):
     cellular  growth/size  hematopoietic system  immune system  mortality/aging 
     reproductive system  tumorigenesis 

    MSI2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MSI2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA surveillance pathway
    		mRNA surveillance pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for MSI2):
        mRNA surveillance pathway


    MSI2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MSI2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/17 Interacting proteins for MSI2 (Q96DH63 ENSP000002840734) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    GRB2P629933, ENSP000003390074I2D: score=3 STRING: ENSP00000339007
    AKT3Q9Y2433I2D: score=3 
    CCNB1P146353I2D: score=3 
    CSNK2A1P684003I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048864stem cell development IEA--


    MSI2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MSI2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSI2
    Search CenterWatch for drugs/clinical trials and news about MSI2 / MSI2H 

    Transcripts
    for MSI2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MSI2 gene (2 alternative transcripts): 
    NM_138962.2  NM_170721.1  

    Unigene Cluster for MSI2:

    Musashi RNA-binding protein 2
    Hs.658922  [show with all ESTs]
    Unigene Representative Sequence: BX647939
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000416426(uc010wnm.1) ENST00000284073(uc002iuz.1) ENST00000581776
    ENST00000581523 ENST00000582453 ENST00000322684(uc002iva.3) ENST00000579590
    ENST00000579531 ENST00000584476 ENST00000579483(uc002ivb.3) ENST00000442934
    ENST00000579180 ENST00000579205 ENST00000579505 ENST00000582772 ENST00000577241
    ENST00000583705 ENST00000583821

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MSI2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSI2
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MSI2 (see all 19):
    hsa-miR-320a hsa-miR-485-5p hsa-miR-218-2* hsa-miR-431 hsa-miR-29b-1* hsa-miR-550a* hsa-miR-10b* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmid: MSI2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSI2
    OriGene shRNA RFP: MSI2
    OriGene siRNA: MSI2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSI2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSI2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MSI2 (NM_170721)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSI2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSI2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSI2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSI2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSI2

    Additional cDNA sequence: 

    AK093888.1 AK128251.1 AK295060.1 AK297295.1 AL833068.1 BC001526.2 BC017560.2 BX647282.1 
    BX647939.1 

    23 DOTS entries:

    DT.414896  DT.309269  DT.100019149  DT.70104884  DT.99952585  DT.95363229  DT.97839601  DT.70105381 
    DT.95090112  DT.91903875  DT.100669782  DT.99995998  DT.100737956  DT.120980342  DT.120980457  DT.91842815 
    DT.92419793  DT.95151406  DT.97785221  DT.100763161  DT.206391  DT.70101257  DT.75189590 

    24/363 AceView cDNA sequences (see all 363):

    AI913722 AI640458 NM_170721 AI972781 BE778519 BQ186552 BQ951490 BF002773 
    BM702269 BC017560 AI422420 BQ929543 AA904280 AA372628 BQ638186 AA252030 
    BU620249 AW250196 BM842394 AW024768 AA804488 BQ416926 BU956366 AI632140 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MSI2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                            -     -     -           -     -                       -           -     -           -                           
    SP2:                                            -     -     -           -     -                       -                                                         
    SP3:                                                                                                  -           -     -                                       
    SP4:                                            -     -     -           -     -                                                                                 
    SP5:                                                                    -     -                       -                                                         


    ECgene alternative splicing isoforms for MSI2

    Expression
    for MSI2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCAGTTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MSI2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSI2

    SOURCE GeneReport for Unigene cluster: Hs.658922

    UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
    Tissue specificity: Ubiquitous; detected at low levels

        SABiosciences Custom PCR Arrays for MSI2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSI2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSI2

    Orthologs
    for MSI2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MSI2 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MSI21 musashi homolog 2 (Drosophila) 83.68(n)
    97.59(a)    		   417667  XM_415912.3  XP_415912.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MSI26
    		 --
    		 99(a)
    		 1 ↔ 1
    		 GL343457.1(116603-667863)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.8752 Xenopus laevis ribonucleoprotein (xrp1) mRNA, complete more 82.48(n)    L02953.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC045335.12   -- 80.43(n)    BC045335.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta msi3
    Rbp61    		 mRNA processing RNA binding3
    RNA-binding protein 61    		 61(a)
    (best of 2)3
    64.81(n)1
    70.73(a)1    		   399191  NM_168718.21  NP_730245.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea msi-11 , 3 RNA binding protein3
    Protein MSI-11    		 60(a)3
    61.66(n)1
    65.24(a)1    		   III(4036780-4039221)3
    1755141  NM_065398.41  NP_497799.11 
    Alicante grape
    (Vitis vinifera)    		 eudicotyledons Vvi.124852 Vitis vinifera transcribed sequence with weak similarity more 74.85(n)    CF512687.1 


    ENSEMBL Gene Tree for MSI2 (if available)
    TreeFam Gene Tree for MSI2 (if available) 

    Paralogs
    for MSI2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSI2 gene
    HNRNPA32  DAZAP12  HNRNPA2B12  HNRNPA1L22  MSI12  HNRNPD2  HNRNPA12  HNRNPA02  
    HNRNPAB2  HNRPDL2  
    18/24 SIMAP similar genes for MSI2 using alignment to 5 protein entries:     MSI2H_HUMAN (see all proteins) (see all similar genes):
    MSI1    RBMX    BOLL    CIRBP    RBMY1A1    HNRNPA2B1
    TARDBP    HNRNPAB    HNRNPD    RBM38    ELAVL2    HNRNPA1
    DAZAP1    SLIRP    D10S102    PABPC1    CELF4    HNRNPA0

    MSI2 for paralogs           About GeneDecksing



    Genomic Variants
    for MSI2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7306 NCBI SNPs in MSI2 are shown (see all 7306)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs351364971,2
    		C,F,--55332220(+) CCTCTC/TACCTT 1 -- us2k18Minor allele frequency- T:0.07NA EA 488
    rs1415217041,2
    		--55332226(+) ACCTTC/TACCAC 1 -- us2k10--------
    rs1861542071,2
    		--55332433(+) ATTGGC/GCATCA 2 -- us2k10--------
    rs1507280401,2
    		--55332495(+) CCCCTC/TATGCC 2 -- us2k10--------
    rs1902721221,2
    		--55332527(+) ACAATG/TTAAAA 2 -- us2k10--------
    rs284528661,2
    		C--55332773(+) TAAGGT/GGGGAG 2 -- us2k12Minor allele frequency- G:0.00NA 4
    rs1807233971,2
    		--55332805(+) CCCTAC/GCTACC 2 -- us2k10--------
    rs1158155351,2
    		F,--55332892(+) AAATAA/CAATAT 2 -- us2k11Minor allele frequency- C:0.07WA 118
    rs733234161,2
    		C,F,--55332937(+) AACCAC/TCCTTC 2 -- us2k13Minor allele frequency- T:0.13WA CSA 122
    rs791115631,2
    		--55333071(+) TAACGC/TGGAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MSI2 (55333212 - 55583212 bp, first 250kb of MSI2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for MSI2
         8 CNVs: 5335 39205 67231 58806 77675 102492 7167 88552
         1 Indel: 58805

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    Disorders / Diseases
    for MSI2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MSI2 for disorders           About GeneDecksing

    OMIM gene information: 607897    OMIM disorders: --

    UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
  • Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia.
    • Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23)

    12 diseases for MSI2:    About MalaCards
    obstructive hydrocephalus    myeloid leukemia    hydrocephalus    brain injury
    chronic myeloid leukemia    acute myeloid leukemia    myeloid malignancy    hepatocellular carcinoma
    leukemia    carcinoma    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: MSI2 (4 documents)

    Export disorders for MSI2 gene to outside databases

    Publications
    for MSI2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSI2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with MSI2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PubMed id 12649177)1, 2, 9 Barbouti A.... Fioretos T. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. (PubMed id 11588182)1, 3 Sakakibara S....Okano H. (2001)
    5. Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients. (PubMed id 22784712)1 Pereira J.K....Favaro P. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia. (PubMed id 21753187)1 Byers R.J....Kutok J.L. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for MSI2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing MSI2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124540 HGNC: 18585 AceView: MSI2 Ensembl:ENSG00000153944 euGenes: HUgn124540
    ECgene: MSI2 Kegg: 124540 H-InvDB: MSI2

    Other Databases showing MSI2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MSI2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSI2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MSI2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MSI2 gene:
    Search GeneIP for patents involving MSI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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