Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MSI2 Gene

Aliases for MSI2 Gene

  • Musashi RNA Binding Protein 2 2 3 5
  • Musashi-2 3 4
  • RNA-Binding Protein Musashi Homolog 2 3
  • Musashi Homolog 2 (Drosophila) 2
  • Musashi Homolog 2 3
  • MSI2H 3

External Ids for MSI2 Gene

Previous GeneCards Identifiers for MSI2 Gene

  • GC17P055073
  • GC17P057815
  • GC17P055676
  • GC17P055808
  • GC17P052688
  • GC17P055334
  • GC17P050694

Summaries for MSI2 Gene

Entrez Gene Summary for MSI2 Gene

  • This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]

GeneCards Summary for MSI2 Gene

MSI2 (Musashi RNA Binding Protein 2) is a Protein Coding gene. Diseases associated with MSI2 include B-Cell Adult Acute Lymphocytic Leukemia. Among its related pathways are mRNA surveillance pathway and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is MSI1.

UniProtKB/Swiss-Prot for MSI2 Gene

  • RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSI2 Gene

Genomics for MSI2 Gene

Regulatory Elements for MSI2 Gene

Enhancers for MSI2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G057460 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +207.7 207686 6.7 HDGF PKNOX1 ZNF493 WRNIP1 ZFP64 ZBTB7B YY1 ZNF121 GATA2 ZNF207 SRSF1 COIL ENSG00000262298 DGKE MSI2 VEZF1 DYNLL2 ENSG00000279281 LOC101927557
GH17G057480 1.5 Ensembl ENCODE dbSUPER 11.4 +228.3 228301 8.1 PKNOX1 ATF1 SIN3A TCF12 ZNF766 ELK1 GATA2 FOS TBX21 MEF2D MSI2 LOC101927557 ENSG00000279281
GH17G057214 1.2 FANTOM5 ENCODE 13 -40.3 -40322 2.3 TBP PKNOX1 SIN3A BMI1 RAD21 ZBTB7B ELK1 GATA2 ZNF207 RCOR1 MSI2 GC17P057199
GH17G057343 1.2 ENCODE dbSUPER 11.8 +87.4 87354 0.1 HDAC1 TBL1XR1 ARID4B BMI1 RAD21 ZSCAN9 YY1 CHAMP1 TCF12 GATA2 MSI2 GC17M057316 GC17P057360
GH17G057130 1.1 Ensembl ENCODE 11.6 -124.7 -124658 0.8 CTCF ARID4B CEBPG RAD21 GATA3 ZNF366 ZBTB48 POLR2A SCRT2 PATZ1 MSI2 ENSG00000263004 ENSG00000263089 GC17P057199
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MSI2 on UCSC Golden Path with GeneCards custom track

Promoters for MSI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096092 1249 3001 HDGF ATF1 FOXA2 ARID4B SIN3A ZNF48 ZBTB7B YY1 GLIS2 KDM4B

Genomic Location for MSI2 Gene

Chromosome:
17
Start:
57,255,851 bp from pter
End:
57,700,477 bp from pter
Size:
444,627 bases
Orientation:
Plus strand

Genomic View for MSI2 Gene

Genes around MSI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSI2 Gene

Proteins for MSI2 Gene

  • Protein details for MSI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DH6-MSI2H_HUMAN
    Recommended name:
    RNA-binding protein Musashi homolog 2
    Protein Accession:
    Q96DH6
    Secondary Accessions:
    • Q7Z6M7
    • Q8N9T4

    Protein attributes for MSI2 Gene

    Size:
    328 amino acids
    Molecular mass:
    35197 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSI2 Gene

Post-translational modifications for MSI2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MSI2

No data available for DME Specific Peptides for MSI2 Gene

Domains & Families for MSI2 Gene

Gene Families for MSI2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DH6

UniProtKB/Swiss-Prot:

MSI2H_HUMAN :
  • Belongs to the Musashi family.
Family:
  • Belongs to the Musashi family.
genes like me logo Genes that share domains with MSI2: view

Function for MSI2 Gene

Molecular function for MSI2 Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in astrocytes after brain injury.

Gene Ontology (GO) - Molecular Function for MSI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0003727 single-stranded RNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008266 poly(U) RNA binding IEA --
genes like me logo Genes that share ontologies with MSI2: view
genes like me logo Genes that share phenotypes with MSI2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MSI2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSI2 Gene

Localization for MSI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSI2 Gene

Cytoplasm. Note=Associated with polysomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSI2 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MSI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IEA --
genes like me logo Genes that share ontologies with MSI2: view

Pathways & Interactions for MSI2 Gene

genes like me logo Genes that share pathways with MSI2: view

Pathways by source for MSI2 Gene

1 KEGG pathway for MSI2 Gene

SIGNOR curated interactions for MSI2 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MSI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048864 stem cell development IEA --
genes like me logo Genes that share ontologies with MSI2: view

Drugs & Compounds for MSI2 Gene

No Compound Related Data Available

Transcripts for MSI2 Gene

Unigene Clusters for MSI2 Gene

Musashi RNA-binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MSI2

Alternative Splicing Database (ASD) splice patterns (SP) for MSI2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: -
SP8: - -
SP9:

Relevant External Links for MSI2 Gene

GeneLoc Exon Structure for
MSI2
ECgene alternative splicing isoforms for
MSI2

Expression for MSI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSI2 Gene

Protein differential expression in normal tissues from HIPED for MSI2 Gene

This gene is overexpressed in Retina (13.6), Bone (12.2), and Testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSI2 Gene



Protein tissue co-expression partners for MSI2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MSI2 Gene:

MSI2

SOURCE GeneReport for Unigene cluster for MSI2 Gene:

Hs.658922

mRNA Expression by UniProt/SwissProt for MSI2 Gene:

Q96DH6-MSI2H_HUMAN
Tissue specificity: Ubiquitous; detected at low levels.

Evidence on tissue expression from TISSUES for MSI2 Gene

  • Skin(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with MSI2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MSI2 Gene

Orthologs for MSI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSI2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MSI2 34
  • 95.63 (n)
mouse
(Mus musculus)
Mammalia Msi2 34 16 35
  • 95.53 (n)
rat
(Rattus norvegicus)
Mammalia Msi2 34
  • 95.2 (n)
cow
(Bos Taurus)
Mammalia MSI2 34 35
  • 94.25 (n)
chimpanzee
(Pan troglodytes)
Mammalia MSI2 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSI2 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSI2 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSI2 34 35
  • 82.77 (n)
lizard
(Anolis carolinensis)
Reptilia MSI2 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msi2 34
  • 84.84 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.875 34
zebrafish
(Danio rerio)
Actinopterygii msi2b 34 35
  • 83.12 (n)
msi2a 35
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006656 34
  • 66.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rbp6 34 35
  • 62.93 (n)
msi 36
  • 61 (a)
sqd 36
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea msi-1 36 35
  • 60 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12485 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for MSI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSI2 Gene

ENSEMBL:
Gene Tree for MSI2 (if available)
TreeFam:
Gene Tree for MSI2 (if available)

Paralogs for MSI2 Gene

Variants for MSI2 Gene

Sequence variations from dbSNP and Humsavar for MSI2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000008848 -- 57,528,664(+) TTGGC(C/T)TGCAG intron-variant
rs1000022412 -- 57,647,842(+) TCACT(A/G)TGTTG intron-variant
rs1000028316 -- 57,475,930(+) AGTCT(G/T)TAGAC intron-variant
rs1000031570 -- 57,418,390(+) ATTGT(A/G)TTGTC intron-variant
rs1000032850 -- 57,567,858(+) AGGGA(C/G)GAGAC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MSI2 Gene

Variant ID Type Subtype PubMed ID
dgv534n67 CNV loss 20364138
dgv5725n54 CNV gain+loss 21841781
dgv5726n54 CNV gain 21841781
dgv70e180 CNV gain 20482838
dgv955e212 CNV loss 25503493
dgv956e212 CNV loss 25503493
esv1002111 CNV deletion 20482838
esv2422464 CNV duplication 17116639
esv2477259 CNV loss 19546169
esv2540858 CNV deletion 19546169
esv26233 CNV gain 19812545
esv2657730 CNV deletion 23128226
esv2663420 CNV deletion 23128226
esv2666575 CNV deletion 23128226
esv2678440 CNV deletion 23128226
esv2716070 CNV deletion 23290073
esv2716071 CNV deletion 23290073
esv2716072 CNV deletion 23290073
esv3302724 CNV tandem duplication 20981092
esv33941 CNV loss 17666407
esv3554596 CNV deletion 23714750
esv3573753 CNV gain 25503493
esv3582835 CNV loss 25503493
esv3582841 CNV loss 25503493
esv3640870 CNV loss 21293372
esv3640871 CNV loss 21293372
esv3640873 CNV loss 21293372
esv3640874 CNV loss 21293372
esv3640875 CNV loss 21293372
esv988833 CNV deletion 20482838
nsv1055155 CNV loss 25217958
nsv1064897 CNV loss 25217958
nsv1066752 CNV loss 25217958
nsv1070835 CNV deletion 25765185
nsv1109088 CNV deletion 24896259
nsv1133410 CNV deletion 24896259
nsv1150917 CNV deletion 26484159
nsv2106 CNV insertion 18451855
nsv2107 CNV deletion 18451855
nsv510718 CNV deletion 20534489
nsv511595 CNV loss 21212237
nsv512496 CNV loss 21212237
nsv575752 CNV gain 21841781
nsv575753 CNV loss 21841781
nsv575754 CNV gain+loss 21841781
nsv575756 CNV loss 21841781
nsv575757 CNV gain 21841781
nsv575762 CNV loss 21841781
nsv819455 CNV gain 19587683
nsv819762 CNV gain 19587683
nsv820633 CNV deletion 20802225
nsv828058 CNV gain+loss 20364138
nsv828061 CNV gain 20364138
nsv828065 CNV loss 20364138
nsv833496 CNV gain 17160897

Variation tolerance for MSI2 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSI2 Gene

Human Gene Mutation Database (HGMD)
MSI2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSI2 Gene

Disorders for MSI2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MSI2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
b-cell adult acute lymphocytic leukemia
  • adult b acute lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search MSI2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MSI2H_HUMAN
  • Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23). {ECO:0000269 PubMed:12649177}.

Relevant External Links for MSI2

Genetic Association Database (GAD)
MSI2
Human Genome Epidemiology (HuGE) Navigator
MSI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSI2
genes like me logo Genes that share disorders with MSI2: view

No data available for Genatlas for MSI2 Gene

Publications for MSI2 Gene

  1. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PMID: 12649177) Barbouti A. … Fioretos T. (Cancer Res. 2003) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MSI2 Gene

  • Addgene plasmids for MSI2

Sources for MSI2 Gene

Content
Loading form....