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Aliases for MSI2 Gene

Aliases for MSI2 Gene

  • Musashi RNA-Binding Protein 2 2 3
  • Musashi-2 3 4
  • RNA-Binding Protein Musashi Homolog 2 3
  • Musashi Homolog 2 (Drosophila) 2
  • Musashi Homolog 2 3
  • MSI2H 3

External Ids for MSI2 Gene

Summaries for MSI2 Gene

Entrez Gene Summary for MSI2 Gene

  • This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSI2 Gene

MSI2 (Musashi RNA-Binding Protein 2) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway. GO annotations related to this gene include nucleotide binding and poly(U) RNA binding. An important paralog of this gene is DAZAP1.

UniProtKB/Swiss-Prot for MSI2 Gene

  • RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSI2 Gene

Genomics for MSI2 Gene

Genomic Location for MSI2 Gene

Start:
57,255,851 bp from pter
End:
57,684,689 bp from pter
Size:
428,839 bases
Orientation:
Plus strand

Genomic View for MSI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSI2 Gene

Regulatory Elements for MSI2 Gene

Proteins for MSI2 Gene

  • Protein details for MSI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DH6-MSI2H_HUMAN
    Recommended name:
    RNA-binding protein Musashi homolog 2
    Protein Accession:
    Q96DH6
    Secondary Accessions:
    • Q7Z6M7
    • Q8N9T4

    Protein attributes for MSI2 Gene

    Size:
    328 amino acids
    Molecular mass:
    35197 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSI2 Gene

Proteomics data for MSI2 Gene at MOPED

Post-translational modifications for MSI2 Gene

No data available for DME Specific Peptides for MSI2 Gene

Domains for MSI2 Gene

Gene Families for MSI2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for MSI2 Gene

UniProtKB/Swiss-Prot:

MSI2H_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • Q96DH6
Family:
  • Belongs to the Musashi family.:
    • Q96DH6
genes like me logo Genes that share domains with MSI2: view

Function for MSI2 Gene

Molecular function for MSI2 Gene

UniProtKB/Swiss-Prot Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated in astrocytes after brain injury.

Gene Ontology (GO) - Molecular Function for MSI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003727 single-stranded RNA binding --
GO:0005515 protein binding IPI 25416956
GO:0008266 poly(U) RNA binding IEA --
genes like me logo Genes that share ontologies with MSI2: view
genes like me logo Genes that share phenotypes with MSI2: view

miRNA for MSI2 Gene

miRTarBase miRNAs that target MSI2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MSI2 Gene

Localization for MSI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSI2 Gene

Cytoplasm. Note=Associated with polysomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSI2 Gene COMPARTMENTS Subcellular localization image for MSI2 gene
Compartment Confidence
cytosol 3
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for MSI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IEA --
genes like me logo Genes that share ontologies with MSI2: view

Pathways for MSI2 Gene

SuperPathways for MSI2 Gene

Superpath Contained pathways
1 mRNA surveillance pathway
genes like me logo Genes that share pathways with MSI2: view

Pathways by source for MSI2 Gene

1 KEGG pathway for MSI2 Gene

Gene Ontology (GO) - Biological Process for MSI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048864 stem cell development IEA --
genes like me logo Genes that share ontologies with MSI2: view

Transcripts for MSI2 Gene

Unigene Clusters for MSI2 Gene

Musashi RNA-binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSI2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: -
SP8: - -
SP9:

Relevant External Links for MSI2 Gene

GeneLoc Exon Structure for
MSI2
ECgene alternative splicing isoforms for
MSI2

Expression for MSI2 Gene

mRNA expression in normal human tissues for MSI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSI2 Gene

SOURCE GeneReport for Unigene cluster for MSI2 Gene Hs.658922

mRNA Expression by UniProt/SwissProt for MSI2 Gene

Q96DH6-MSI2H_HUMAN
Tissue specificity: Ubiquitous; detected at low levels.
genes like me logo Genes that share expressions with MSI2: view

Orthologs for MSI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSI2 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSI2 36
  • 94.25 (n)
  • 99.67 (a)
MSI2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSI2 36
  • 95.63 (n)
  • 98.17 (a)
mouse
(Mus musculus)
Mammalia Msi2 36
  • 95.53 (n)
  • 99.7 (a)
Msi2 16
Msi2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSI2 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSI2 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msi2 36
  • 95.2 (n)
  • 99.64 (a)
chicken
(Gallus gallus)
Aves MSI2 36
  • 82.77 (n)
  • 96.6 (a)
MSI2 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSI2 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.875 36
tropical clawed frog
(Silurana tropicalis)
Amphibia msi2 36
  • 84.84 (n)
  • 96.13 (a)
zebrafish
(Danio rerio)
Actinopterygii msi2a 37
  • 78 (a)
OneToMany
msi2b 36
  • 83.12 (n)
  • 93.91 (a)
msi2b 37
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006656 36
  • 66.78 (n)
  • 71.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rbp6 36
  • 62.93 (n)
  • 66.67 (a)
Rbp6 37
  • 36 (a)
OneToMany
msi 38
  • 61 (a)
sqd 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea msi-1 37
  • 50 (a)
OneToMany
msi-1 38
  • 60 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12485 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToMany
Species with no ortholog for MSI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSI2 Gene

ENSEMBL:
Gene Tree for MSI2 (if available)
TreeFam:
Gene Tree for MSI2 (if available)

Paralogs for MSI2 Gene

Paralogs for MSI2 Gene

genes like me logo Genes that share paralogs with MSI2: view

Variants for MSI2 Gene

Sequence variations from dbSNP and Humsavar for MSI2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11136 -- 57,681,574(-) NNNNT(G/T)AGTTA utr-variant-3-prime
rs13586 -- 57,681,500(-) GTCTA(A/C)TTTGT utr-variant-3-prime
rs277060 -- 57,484,733(-) CAGGG(A/C)TGGAG intron-variant
rs277061 -- 57,485,112(-) AACAC(A/C)CATTT intron-variant
rs277062 -- 57,485,255(-) GAAAC(A/T)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSI2 Gene

Variant ID Type Subtype PubMed ID
esv33941 CNV Loss 17666407
nsv2106 CNV Insertion 18451855
nsv819455 CNV Gain 19587683
esv259698 OTHER Complex 20981092
esv2678440 CNV Deletion 23128226
esv2422464 CNV Duplication 17116639
nsv833496 CNV Gain 17160897
nsv510718 CNV Loss 20534489
esv2666575 CNV Deletion 23128226
esv1002111 CNV Deletion 20482838
esv2716070 CNV Deletion 23290073
esv988833 CNV Deletion 20482838
nsv819762 CNV Gain 19587683
nsv512496 CNV Loss 21212237
esv2540858 CNV Deletion 19546169
nsv511595 CNV Loss 21212237
esv2716071 CNV Deletion 23290073
dgv70e180 CNV Gain 20482838
nsv828058 CNV Gain+Loss 20364138
dgv534n67 CNV Loss 20364138
nsv820633 CNV Deletion 20802225
esv2663420 CNV Deletion 23128226
esv26233 CNV Gain 19812545
esv2477259 CNV Loss 19546169
nsv828061 CNV Gain 20364138
nsv828065 CNV Loss 20364138
esv2657730 CNV Deletion 23128226
esv2716072 CNV Deletion 23290073
nsv2107 CNV Loss 18451855
dgv3233n71 CNV Loss 21882294
dgv3234n71 CNV Loss 21882294

Relevant External Links for MSI2 Gene

HapMap Linkage Disequilibrium report
MSI2

Disorders for MSI2 Gene

UniProtKB/Swiss-Prot

MSI2H_HUMAN
  • Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).

Relevant External Links for MSI2

Genetic Association Database (GAD)
MSI2
Human Genome Epidemiology (HuGE) Navigator
MSI2
genes like me logo Genes that share disorders with MSI2: view

Publications for MSI2 Gene

  1. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PMID: 12649177) Barbouti A. … Fioretos T. (Cancer Res. 2003) 3 4 23
  2. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. (PMID: 11588182) Sakakibara S. … Okano H. (J. Neurosci. 2001) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for MSI2 Gene

Sources for MSI2 Gene

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