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MSI2 Gene

protein-coding   GIFtS: 63
GCID: GC17P055334

Musashi RNA-Binding Protein 2

(Previous name: musashi homolog 2 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Musashi RNA-Binding Protein 21 2     musashi-22
Musashi Homolog 2 (Drosophila)1     RNA-Binding Protein Musashi Homolog 22
MSI2H2     Musashi-23
Musashi Homolog 22     

External Ids:    HGNC: 185851   Entrez Gene: 1245402   Ensembl: ENSG000001539447   OMIM: 6078975   UniProtKB: Q96DH63   

Export aliases for MSI2 gene to outside databases

Previous GC identifers: GC17P055073 GC17P057815 GC17P055676 GC17P055808 GC17P052688 GC17P050694


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSI2 Gene:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other
species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two
transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MSI2 Gene:
MSI2 (musashi RNA-binding protein 2) is a protein-coding gene. Diseases associated with MSI2 include obstructive hydrocephalus, and hydrocephalus. GO annotations related to this gene include poly(U) RNA binding and nucleotide binding. An important paralog of this gene is TARDBP.

UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a
role in the proliferation and maintenance of stem cells in the central nervous system (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSI2 gene promoter:
         AREB6   PPAR-alpha   S8   Chx10   Nkx2-5   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSI2 promoter sequence
   Search Chromatin IP Primers for MSI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

MSI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSI2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P055334:  view genomic region     (about GC identifiers)

Start:
55,333,212 bp from pter      End:
55,762,046 bp from pter
Size:
428,835 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6 (See protein sequence)
Recommended Name: RNA-binding protein Musashi homolog 2  
Size: 328 amino acids; 35197 Da
Secondary accessions: Q7Z6M7 Q8N9T4
Alternative splicing: 3 isoforms:  Q96DH6-1   Q96DH6-2   Q96DH6-3   (Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. Contains a phosphoserine at position 14)

Explore the universe of human proteins at neXtProt for MSI2: NX_Q96DH6

Explore proteomics data for MSI2 at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • Ubiquitination2 at Lys43, Lys145, Lys166
  • Modification sites at PhosphoSitePlus

  • See MSI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_620412.1  NP_733839.1  

    ENSEMBL proteins: 
     ENSP00000414671   ENSP00000284073   ENSP00000463227   ENSP00000313616   ENSP00000462914  
     ENSP00000392607   ENSP00000462264  

    MSI2 Human Recombinant Protein Products:

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    OriGene MassSpec for MSI2
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    Novus Biologicals MSI2 Proteins
    Novus Biologicals MSI2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MSI2
    Cloud-Clone Corp. Proteins for MSI2

    MSI2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MSI2
    R&D Systems Antibodies for MSI2 (Musashi-2)
    OriGene Antibodies for MSI2
    OriGene Custom Antibody Services for MSI2
    Novus Biologicals MSI2 Antibodies
    Abcam antibodies for MSI2
    Cloud-Clone Corp. Antibodies for MSI2
    ThermoFisher Antibody for MSI2
    LSBio Antibodies in human, mouse, rat for MSI2

    MSI2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MSI2
    OriGene Custom Assay Services for MSI2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MSI2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MSI2
    Cloud-Clone Corp. CLIAs for MSI2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q96DH6

    ProtoNet protein and cluster: Q96DH6

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
    Similarity: Belongs to the Musashi family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    MSI2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSI2H_HUMAN, Q96DH6
    Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a
    role in the proliferation and maintenance of stem cells in the central nervous system (By similarity)
    Induction: Up-regulated in astrocytes after brain injury (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003727single-stranded RNA binding ----
    GO:0008266poly(U) RNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    MSI2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MSI2:
     Decreased viability of wild-ty  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Msi2):
     growth/size/body  hematopoietic system  immune system  mortality/aging  reproductive system 
     tumorigenesis 

    MSI2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSI2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSI2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSI2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MSI2:
    hsa-mir-484 (MIRT042254), hsa-mir-652-3p (MIRT039469), hsa-mir-155-5p (MIRT001533)

    Block miRNA regulation of human, mouse, rat MSI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSI2 (see all 19):
    hsa-miR-320a hsa-miR-485-5p hsa-miR-218-2* hsa-miR-431 hsa-miR-29b-1* hsa-miR-550a* hsa-miR-10b* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidMSI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MSI2
    Predesigned siRNA for gene silencing in human, mouse, rat MSI2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MSI2

    Clone
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    OriGene clones in human, mouse for MSI2 (see all 12)
    OriGene ORF clones in mouse, rat for MSI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MSI2 (NM_170721)
    Sino Biological Human cDNA Clone for MSI2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSI2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MSI2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MSI2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MSI2H_HUMAN, Q96DH6: Cytoplasm. Note=Associated with polysomes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--

    MSI2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MSI2 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for MSI2):
        mRNA surveillance pathway


    MSI2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSI2
    Interactions:

        GeneGlobe Interaction Network for MSI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MSI2 (Q96DH63 ENSP000002840734) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    GRB2P629933, ENSP000003390074I2D: score=3 STRING: ENSP00000339007
    AKT3Q9Y2433I2D: score=3 
    CCNB1P146353I2D: score=3 
    CSNK2A1P684003I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048864stem cell development IEA--

    MSI2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSI2 (MSI2H)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MSI2 gene (2 alternative transcripts): 
    NM_138962.2  NM_170721.1  

    Unigene Cluster for MSI2:

    Musashi RNA-binding protein 2
    Hs.658922  [show with all ESTs]
    Unigene Representative Sequence: BX647939
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000416426(uc010wnm.1) ENST00000284073(uc002iuz.1) ENST00000581776
    ENST00000581523 ENST00000582453 ENST00000322684(uc002iva.3) ENST00000579590
    ENST00000579531 ENST00000584476 ENST00000579483(uc002ivb.3) ENST00000442934
    ENST00000579180 ENST00000579205 ENST00000579505 ENST00000582772 ENST00000577241
    ENST00000583705 ENST00000583821
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MSI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSI2 (see all 19):
    hsa-miR-320a hsa-miR-485-5p hsa-miR-218-2* hsa-miR-431 hsa-miR-29b-1* hsa-miR-550a* hsa-miR-10b* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidMSI2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MSI2
    Predesigned siRNA for gene silencing in human, mouse, rat MSI2
    Clone
    Products:
         
    OriGene clones in human, mouse for MSI2 (see all 12)
    OriGene ORF clones in mouse, rat for MSI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MSI2 (NM_170721)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSI2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MSI2
    OriGene qSTAR qPCR primer pairs in human, mouse for MSI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSI2
      QuantiTect SYBR Green Assays in human, mouse, rat MSI2
      QuantiFast Probe-based Assays in human, mouse, rat MSI2

    Additional mRNA sequence: 

    AK093888.1 AK128251.1 AK295060.1 AK297295.1 AL833068.1 BC001526.2 BC017560.2 BX647282.1 
    BX647939.1 

    23 DOTS entries:

    DT.414896  DT.309269  DT.100019149  DT.70104884  DT.99952585  DT.95363229  DT.97839601  DT.70105381 
    DT.95090112  DT.91903875  DT.100669782  DT.99995998  DT.100737956  DT.120980342  DT.120980457  DT.91842815 
    DT.92419793  DT.95151406  DT.97785221  DT.100763161  DT.206391  DT.70101257  DT.75189590 

    Selected AceView cDNA sequences (see all 363):

    BF589094 AK128251 AA425281 AW590496 BF446124 BU740790 CA426173 AW134658 
    AA364681 CA943839 CA432713 BF196671 NM_138962 BM264417 AI632140 BM978628 
    BQ416926 AW024768 BU956366 AW250196 BM842394 AA804488 BU620249 AA252030 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MSI2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                            -     -     -           -     -                       -           -     -           -                           
    SP2:                                            -     -     -           -     -                       -                                                         
    SP3:                                                                                                  -           -     -                                       
    SP4:                                            -     -     -           -     -                                                                                 
    SP5:                                                                    -     -                       -                                                         


    ECgene alternative splicing isoforms for MSI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGTTTGG
    MSI2 Expression
    About this image


    MSI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MSI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658922

    UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
    Tissue specificity: Ubiquitous; detected at low levels

        Custom PCR Arrays for MSI2
    Primer
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    OriGene qPCR primer pairs and template standards for MSI2
    OriGene qSTAR qPCR primer pairs in human, mouse for MSI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSI2
    QuantiTect SYBR Green Assays in human, mouse, rat MSI2
    QuantiFast Probe-based Assays in human, mouse, rat MSI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MSI2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msi21 , 5 Musashi homolog 2 (Drosophila)5
    musashi RNA-binding protein 21
    95.53(n)1
    99.7(a)1
      11 (52.40 cM)5
    766261  NM_054043.31  NP_473384.11 
     883393825 
    chicken
    (Gallus gallus)
    Aves MSI21 musashi homolog 2 (Drosophila) 82.77(n)
    96.6(a)
      417667  XM_415912.4  XP_415912.4 
    lizard
    (Anolis carolinensis)
    Reptilia MSI26
    musashi RNA-binding protein 2
    68(a)
    1 ↔ 1
    GL343457.1(116564-668312)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8752 Xenopus laevis ribonucleoprotein (xrp1) mRNA, complete more 82.48(n)    L02953.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045335.12   -- 80.43(n)    BC045335.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msi3
    Rbp61
    mRNA processing RNA binding3
    RNA-binding protein 61
    61(a)
    (best of 2)3
    62.93(n)1
    66.67(a)1
      399191  NM_001275050.11  NP_001261979.11 
    worm
    (Caenorhabditis elegans)
    Secernentea msi-13 RNA binding protein 60(a)   III(4036780-4039221)   --
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.124852 Vitis vinifera transcribed sequence with weak similarity more 74.85(n)    CF512687.1 


    ENSEMBL Gene Tree for MSI2 (if available)
    TreeFam Gene Tree for MSI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSI2 gene
    TARDBP2  DAZAP12  MSI12  
    Selected SIMAP similar genes for MSI2 using alignment to 5 protein entries:     MSI2H_HUMAN (see all proteins) (see all similar genes):
    MSI1    RBMX    BOLL    CIRBP    RBMY1A1    HNRNPA2B1
    TARDBP    HNRNPAB    HNRNPD    DAZ4    RBM38    HNRNPA1
    ELAVL2    SLIRP    D10S102    DAZAP1    CELF2    PABPC1

    MSI2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSI2 (see all 8475)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7532261,2
    C--50901682(+) tgtgtA/Gtatgt 1 -- int10--------
    rs1861542071,2
    --55332433(+) ATTGGC/GCATCA 2 -- us2k10--------
    rs1507280401,2
    --55332495(+) CCCCTC/TATGCC 2 -- us2k10--------
    rs1902721221,2
    --55332527(+) ACAATG/TTAAAA 2 -- us2k10--------
    rs284528661,2
    C--55332773(+) TAAGGT/GGGGAG 2 -- us2k12Minor allele frequency- G:0.00NA 4
    rs1807233971,2
    C--55332805(+) CCCTAC/GCTACC 2 -- us2k10--------
    rs1158155351,2
    C,F--55332892(+) AAATAA/CAATAT 2 -- us2k11Minor allele frequency- C:0.07WA 118
    rs733234161,2
    C,F--55332937(+) AACCAC/TCCTTC 2 -- us2k13Minor allele frequency- T:0.13WA CSA 122
    rs791115631,2
    --55333071(+) TAACGC/TGGAAA 2 -- us2k10--------
    rs1499505771,2
    --55333097(+) TTTCTA/CGCCAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MSI2 (55333212 - 55583212 bp, first 250kb of MSI2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MSI2 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716070CNV Deletion23290073
    esv2666575CNV Deletion23128226
    nsv820633CNV Deletion20802225
    esv2716071CNV Deletion23290073
    esv988833CNV Deletion20482838
    esv2657730CNV Deletion23128226
    esv2716072CNV Deletion23290073
    esv2540858CNV Deletion19546169
    esv2663420CNV Deletion23128226
    esv2678440CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSI2
    DNA2.0 Custom Variant and Variant Library Synthesis for MSI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607897    OMIM disorders: --

    UniProtKB/Swiss-Prot: MSI2H_HUMAN, Q96DH6
  • Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid
    leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23)

  • 20 diseases for MSI2:    
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    obstructive hydrocephalus    hydrocephalus    brain injury    brain cancer
    myeloid leukemia    chronic myeloid leukemia    myelodysplastic syndromes    acute myeloid leukemia
    bipolar disorder    lymphoblastic leukemia    leukemia    tonsillitis
    hepatocellular carcinoma    multiple myeloma    thyroiditis    myeloma
    cerebritis    malaria    prostatitis    neuronitis


    MSI2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MSI2
    Human Genome Epidemiology (HuGE) Navigator: MSI2 (4 documents)

    Export disorders for MSI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSI2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with MSI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PubMed id 12649177)1, 2, 9 Barbouti A.... Fioretos T. (Cancer Res. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. (PubMed id 11588182)1, 3 Sakakibara S....Okano H. (J. Neurosci. 2001)
    7. Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway. (PubMed id 24076374)1 Zhang H....Zhang L. (Exp. Cell Res. 2014)
    8. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    9. High expression of Musashi-2 indicates poor prognosis in adult B-cell acute lymphoblastic leukemia. (PubMed id 23759245)1 Mu Q....Jin J. (Leuk. Res. 2013)
    10. Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia. (PubMed id 23233047)1 Thol F....Heuser M. (Ann. Hematol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124540 HGNC: 18585 AceView: MSI2 Ensembl:ENSG00000153944 euGenes: HUgn124540
    ECgene: MSI2 Kegg: 124540 H-InvDB: MSI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSI2 gene:
    Search GeneIP for patents involving MSI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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