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Aliases for MSI2 Gene

Aliases for MSI2 Gene

  • Musashi RNA Binding Protein 2 2 3 5
  • Musashi-2 3 4
  • Musashi Homolog 2 (Drosophila) 2
  • Musashi RNA-Binding Protein 2 3
  • Musashi Homolog 2 3
  • MSI2H 3

External Ids for MSI2 Gene

Previous GeneCards Identifiers for MSI2 Gene

  • GC17P055073
  • GC17P057815
  • GC17P055676
  • GC17P055808
  • GC17P052688
  • GC17P055334
  • GC17P050694

Summaries for MSI2 Gene

Entrez Gene Summary for MSI2 Gene

  • This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]

GeneCards Summary for MSI2 Gene

MSI2 (Musashi RNA Binding Protein 2) is a Protein Coding gene. Diseases associated with MSI2 include Leukemia, Acute Myeloid. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and mRNA surveillance pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DAZAP1.

UniProtKB/Swiss-Prot for MSI2 Gene

  • RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSI2 Gene

Genomics for MSI2 Gene

Regulatory Elements for MSI2 Gene

Enhancers for MSI2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MSI2 on UCSC Golden Path with GeneCards custom track

Promoters for MSI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MSI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MSI2 Gene

57,255,851 bp from pter
57,700,477 bp from pter
444,627 bases
Plus strand

Genomic View for MSI2 Gene

Genes around MSI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSI2 Gene

Proteins for MSI2 Gene

  • Protein details for MSI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein Musashi homolog 2
    Protein Accession:
    Secondary Accessions:
    • Q7Z6M7
    • Q8N9T4

    Protein attributes for MSI2 Gene

    328 amino acids
    Molecular mass:
    35197 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MSI2 Gene


neXtProt entry for MSI2 Gene

Proteomics data for MSI2 Gene at MOPED

Post-translational modifications for MSI2 Gene

Antibody Products

No data available for DME Specific Peptides for MSI2 Gene

Domains & Families for MSI2 Gene

Gene Families for MSI2 Gene

Protein Domains for MSI2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the Musashi family.
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the Musashi family.
genes like me logo Genes that share domains with MSI2: view

Function for MSI2 Gene

Molecular function for MSI2 Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in astrocytes after brain injury.

Gene Ontology (GO) - Molecular Function for MSI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008266 poly(U) RNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MSI2: view
genes like me logo Genes that share phenotypes with MSI2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MSI2 Gene

Localization for MSI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSI2 Gene

Cytoplasm. Note=Associated with polysomes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for MSI2 Gene COMPARTMENTS Subcellular localization image for MSI2 gene
Compartment Confidence
cytosol 3
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for MSI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MSI2: view

Pathways & Interactions for MSI2 Gene

genes like me logo Genes that share pathways with MSI2: view

Pathways by source for MSI2 Gene

1 KEGG pathway for MSI2 Gene

SIGNOR curated interactions for MSI2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MSI2 Gene


Drugs & Compounds for MSI2 Gene

No Compound Related Data Available

Transcripts for MSI2 Gene

Unigene Clusters for MSI2 Gene

Musashi RNA-binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSI2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: -
SP8: - -

Relevant External Links for MSI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MSI2 Gene

mRNA expression in normal human tissues for MSI2 Gene

Protein differential expression in normal tissues from HIPED for MSI2 Gene

This gene is overexpressed in Retina (13.6), Bone (12.2), and Testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSI2 Gene

SOURCE GeneReport for Unigene cluster for MSI2 Gene Hs.658922

mRNA Expression by UniProt/SwissProt for MSI2 Gene

Tissue specificity: Ubiquitous; detected at low levels.
genes like me logo Genes that share expression patterns with MSI2: view

Protein tissue co-expression partners for MSI2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MSI2 Gene

Orthologs for MSI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MSI2 35
  • 94.25 (n)
  • 99.67 (a)
MSI2 36
  • 86 (a)
(Canis familiaris)
Mammalia MSI2 35
  • 95.63 (n)
  • 98.17 (a)
(Mus musculus)
Mammalia Msi2 35
  • 95.53 (n)
  • 99.7 (a)
Msi2 16
Msi2 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Msi2 35
  • 95.2 (n)
  • 99.64 (a)
(Monodelphis domestica)
Mammalia MSI2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MSI2 36
  • 73 (a)
(Pan troglodytes)
Mammalia MSI2 36
  • 94 (a)
(Gallus gallus)
Aves MSI2 35
  • 82.77 (n)
  • 96.6 (a)
MSI2 36
  • 89 (a)
(Anolis carolinensis)
Reptilia MSI2 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia msi2 35
  • 84.84 (n)
  • 96.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.875 35
(Danio rerio)
Actinopterygii msi2b 35
  • 83.12 (n)
  • 93.91 (a)
msi2a 36
  • 78 (a)
msi2b 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta msi 37
  • 61 (a)
sqd 37
  • 40 (a)
Rbp6 35
  • 62.93 (n)
  • 66.67 (a)
Rbp6 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006656 35
  • 66.78 (n)
  • 71.73 (a)
(Caenorhabditis elegans)
Secernentea msi-1 37
  • 60 (a)
msi-1 36
  • 50 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12485 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for MSI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSI2 Gene

Gene Tree for MSI2 (if available)
Gene Tree for MSI2 (if available)

Paralogs for MSI2 Gene

Paralogs for MSI2 Gene

genes like me logo Genes that share paralogs with MSI2: view

Variants for MSI2 Gene

Sequence variations from dbSNP and Humsavar for MSI2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11136 -- 57,681,574(-) NNNNT(G/T)AGTTA intron-variant, utr-variant-3-prime
rs13586 -- 57,681,500(-) GTCTA(A/C)TTTGT intron-variant, utr-variant-3-prime
rs920748 -- 57,360,128(-) CCATC(A/G)TAATA intron-variant
rs929648 -- 57,507,759(+) ATATG(A/C)CGTCC intron-variant
rs930521 -- 57,386,942(-) GGGAA(A/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSI2 Gene

Variant ID Type Subtype PubMed ID
esv33941 CNV Loss 17666407
nsv2106 CNV Insertion 18451855
nsv819455 CNV Gain 19587683
esv259698 OTHER Complex 20981092
esv2678440 CNV Deletion 23128226
esv2422464 CNV Duplication 17116639
nsv833496 CNV Gain 17160897
nsv510718 CNV Loss 20534489
esv2666575 CNV Deletion 23128226
esv1002111 CNV Deletion 20482838
esv2716070 CNV Deletion 23290073
esv988833 CNV Deletion 20482838
nsv819762 CNV Gain 19587683
nsv512496 CNV Loss 21212237
esv2540858 CNV Deletion 19546169
nsv511595 CNV Loss 21212237
esv2716071 CNV Deletion 23290073
dgv70e180 CNV Gain 20482838
nsv828058 CNV Gain+Loss 20364138
dgv534n67 CNV Loss 20364138
nsv820633 CNV Deletion 20802225
esv2663420 CNV Deletion 23128226
esv26233 CNV Gain 19812545
esv2477259 CNV Loss 19546169
nsv828061 CNV Gain 20364138
nsv828065 CNV Loss 20364138
esv2657730 CNV Deletion 23128226
esv2716072 CNV Deletion 23290073
nsv2107 CNV Loss 18451855
dgv3233n71 CNV Loss 21882294
dgv3234n71 CNV Loss 21882294

Variation tolerance for MSI2 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MSI2 Gene

Disorders for MSI2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MSI2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search MSI2 in MalaCards View complete list of genes associated with diseases


  • Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23). {ECO:0000269 PubMed:12649177}.

Relevant External Links for MSI2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MSI2: view

No data available for Genatlas for MSI2 Gene

Publications for MSI2 Gene

  1. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PMID: 12649177) Barbouti A. … Fioretos T. (Cancer Res. 2003) 3 4 23 67
  2. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. (PMID: 11588182) Sakakibara S. … Okano H. (J. Neurosci. 2001) 2 3
  3. Prognostic significance of MSI2 predicts unfavorable outcome in adult B-acute lymphoblastic leukemia. (PMID: 25090928) Aly R.M. … Ghazy H.F. (Int J Lab Hematol 2015) 3
  4. Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. (PMID: 25664853) Park S.M. … Kharas M.G. (J. Clin. Invest. 2015) 3
  5. Transformation of the intestinal epithelium by the MSI2 RNA-binding protein. (PMID: 25774828) Wang S. … Lengner C.J. (Nat Commun 2015) 3

Products for MSI2 Gene

Sources for MSI2 Gene