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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSI1 Gene

protein-coding   GIFtS: 63
GCID: GC12M120779

Musashi RNA-Binding Protein 1

(Previous names: Musashi (Drosophila) homolog 1, musashi homolog 1 (Drosophila))
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Musashi RNA-Binding Protein 11 2     musashi12
Musashi (Drosophila) Homolog 11     RNA-Binding Protein Musashi Homolog 12
Musashi Homolog 1 (Drosophila)1     Musashi-13
musashi-12     

External Ids:    HGNC: 73301   Entrez Gene: 44402   Ensembl: ENSG000001350977   OMIM: 6033285   UniProtKB: O433473   

Export aliases for MSI1 gene to outside databases

Previous GC identifers: GC12M119653 GC12M120306 GC12M120561 GC12M119191 GC12M119241 GC12M119263 GC12M117787


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MSI1 Gene:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other
species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation.
Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in
gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. (provided by RefSeq, Jul 2008)

GeneCards Summary for MSI1 Gene: 
MSI1 (musashi RNA-binding protein 1) is a protein-coding gene. Diseases associated with MSI1 include gliosarcoma, and malignant glioma. GO annotations related to this gene include poly(U) RNA binding and RNA binding. An important paralog of this gene is MSI2.

UniProtKB/Swiss-Prot: MSI1H_HUMAN, O43347
Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates
expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other
sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of
stem cells in the central nervous system (By similarity)

Gene Wiki entry for MSI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSI1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   p53   Sox9   E2F-2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

MSI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSI1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120779:  view genomic region     (about GC identifiers)

Start:
120,779,133 bp from pter      End:
120,806,983 bp from pter
Size:
27,851 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MSI1H_HUMAN, O43347 (See protein sequence)
Recommended Name: RNA-binding protein Musashi homolog 1  
Size: 362 amino acids; 39125 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q96PU0 Q96PU1 Q96PU2 Q96PU3

Explore the universe of human proteins at neXtProt for MSI1: NX_O43347

Explore proteomics data for MSI1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43347

  • MSI1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MSI1 Protein Expression
    REFSEQ proteins: NP_002433.1  
    ENSEMBL proteins: 
     ENSP00000257552   ENSP00000446710  

    Human Recombinant Protein Products for MSI1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for MSI1
    OriGene Protein Over-expression Lysate for MSI1
    OriGene MassSpec for MSI1 
    OriGene Custom Protein Services for MSI1
    GenScript Custom Purified and Recombinant Proteins Services for MSI1
    Novus Biologicals MSI1 Protein
    Novus Biologicals MSI1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MSI1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--

    MSI1 for ontologies           About GeneDecksing



    MSI1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MSI1
    R&D Systems Antibodies for MSI1 (Musashi-1)
    Cell Signaling Technology (CST) Antibodies for MSI1 
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    GenScript Custom Superior Antibodies Services for MSI1
    Novus Biologicals MSI1 Antibodies
    Abcam antibodies for MSI1
    Cloud-Clone Corp. Antibodies for MSI1 
    ThermoFisher Antibody for MSI1
    LSBio Antibodies in human, mouse, rat for MSI1 

    Assay Products for MSI1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MSI1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MSI1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MSI1 
    Cloud-Clone Corp. CLIAs for MSI1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O43347

    ProtoNet protein and cluster: O43347

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: MSI1H_HUMAN, O43347
    Domain: The first RNA recognition motif binds more strongly to RNA compared to the second one (By similarity)
    Similarity: Belongs to the Musashi family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    MSI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSI1H_HUMAN, O43347
    Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates
    expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other
    sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of
    stem cells in the central nervous system (By similarity)

         Genatlas biochemistry entry for MSI1:
    Musahi (Drosophila) homolog 1,39kDa,neural RNA-binding protein putatively expressed in CNS stem cells and neural
    progenitor cells,with an alternatively spliced isoform

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS9790759
    GO:0003727single-stranded RNA binding ----
    GO:0008266poly(U) RNA binding IEA--
         
    MSI1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MSI1:
     Decreased cilium length after  

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Msi1):
     behavior/neurological  cardiovascular system  craniofacial  homeostasis/metabolism  mortality/aging 
     nervous system  normal  skeleton 

    MSI1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Msi1tm1Okn for MSI1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MSI1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MSI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSI1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSI1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSI1
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate MSI1 (see all 95):
    hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-607 hsa-miR-1321 hsa-miR-342-3p hsa-miR-149 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidMSI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MSI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSI1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MSI1

    Clone
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    OriGene clones in human, mouse for MSI1 (see all 6)
    OriGene ORF clones in mouse, rat for MSI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSI1 (NM_002442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSI1
    Sirion Biotech Customized lentivirus for stable overexpression of MSI1 
                         Customized lentivirus expression plasmids for stable overexpression of MSI1 

    Cell Line
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    Search LifeMap BioReagents cell lines for MSI1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSI1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MSI1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway
    2Neuroscience
    Neuroscience
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for MSI1
        Wnt / Hedgehog / Notch
    Neuroscience


    1         Kegg Pathway  (Kegg details for MSI1):
        mRNA surveillance pathway


    MSI1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSI1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for MSI1 (O433472, 3 ENSP000002575524) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNMA1Q8ND902, 3, ENSP000003189144MINT-64999 I2D: score=4 STRING: ENSP00000318914
    CAMKK2Q96RR43I2D: score=1 
    CLN3Q132863I2D: score=1 
    PKP3Q9Y4463I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS9790759
    GO:0009725response to hormone stimulus IEA--
    GO:0030855epithelial cell differentiation IEA--

    MSI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSI1 (MSI1H)

    Search CenterWatch for drugs/clinical trials and news about MSI1 / MSI1H

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSI1 gene: 
    NM_002442.3  

    Unigene Cluster for MSI1:

    Musashi RNA-binding protein 1
    Hs.158311  [show with all ESTs]
    Unigene Representative Sequence: NM_002442
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257552(uc001tye.1) ENST00000546985 ENST00000546622

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSI1
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate MSI1 (see all 95):
    hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-607 hsa-miR-1321 hsa-miR-342-3p hsa-miR-149 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidMSI1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MSI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSI1
    Clone
    Products:
         
    OriGene clones in human, mouse for MSI1 (see all 6)
    OriGene ORF clones in mouse, rat for MSI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSI1 (NM_002442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSI1
    Sirion Biotech Customized lentivirus for stable overexpression of MSI1 
                         Customized lentivirus expression plasmids for stable overexpression of MSI1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MSI1
    OriGene qSTAR qPCR primer pairs in human, mouse for MSI1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSI1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSI1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSI1

    Additional mRNA sequence: 

    AB012851.1 AB072590.1 AB072591.1 AB072592.1 AB073212.1 AK023262.1 

    4 DOTS entries:

    DT.92062855  DT.97772555  DT.97834650  DT.97836642 

    24/36 AceView cDNA sequences (see all 36):

    BM684276 BM701308 BM313429 AI583233 AL040010 BX282129 BM696052 NM_002442 
    BM715963 AW770583 AA084640 CK822013 BQ638220 AK023262 AB073212 AU132470 
    AB072590 AB072591 BX098565 AB072592 H42504 BX404216 AB012851 BM681342 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSI1 expression in normal human tissues (normalized intensities)      MSI1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTTCGAA
    MSI1 Expression
    About this image


    MSI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Cardiac progenitor cells (Sca1+)
     
     Spinal Cord (Nervous System)
             Neural stem cells
     
     Eye (Sensory Organs)

    See MSI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSI1

    SOURCE GeneReport for Unigene cluster: Hs.158311

    UniProtKB/Swiss-Prot: MSI1H_HUMAN, O43347
    Tissue specificity: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in
    hepatoma cell lines

        SABiosciences Custom PCR Arrays for MSI1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MSI1 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msi11 , 5 Musashi homolog 1(Drosophila)1, 5 93.28(n)1
    99.45(a)1
      5 (56.09 cM)5
    176901  NM_008629.11  NP_032655.11 
     1154295995 
    chicken
    (Gallus gallus)
    Aves MSI11 musashi homolog 1 (Drosophila) 79.71(n)
    90.06(a)
      416979  XM_415271.3  XP_415271.3 
    lizard
    (Anolis carolinensis)
    Reptilia MSI16
    Uncharacterized protein
    94(a)
    1 ↔ 1
    GL343338.1(26845-50277)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8362 X.laevis nervous system-specific RNA-binding protein more 79.08(n)    M34894.1 
    zebrafish
    (Danio rerio)
    Actinopterygii msi11 musashi homolog 1 (Drosophila) 77.98(n)
    88.79(a)
      541389  NM_001013516.1  NP_001013534.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msi3 mRNA processing RNA binding 58(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea msi-13 RNA binding protein 58(a)   III(4036780-4039221)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRP1(YOL123W)4 Subunit of cleavage factor I, a five-subunit complex more   --   15(87844-89448) 853997  NP_014518.1 


    ENSEMBL Gene Tree for MSI1 (if available)
    TreeFam Gene Tree for MSI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSI1 gene
    MSI22  TARDBP2  
    12 SIMAP similar genes for MSI1 using alignment to 2 protein entries:     MSI1H_HUMAN (see all proteins):
    MSI2    HNRNPA2B1    D10S102    HNRNPAB    HNRPA3    HNRNPA1L2
    HNRNPA3    HNRNPD    HNRNPA1    RBM38    HNRPA1    HNRNPA0

    MSI1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/572 SNPs in MSI1 are shown (see all 572)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354854
    A breast cancer sample4--see VAR_0354852 E Q mis40--------
    rs349261251,2
    C--120778689(+) TATTCT/-TTTTT 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs2011172141,2
    C--120778689(+) CTATTC/TTTTTT 1 -- ds50010--------
    rs1830996171,2
    --120778765(+) CTCACC/TGCAGC 1 -- ds50010--------
    rs1417284301,2
    --120778906(+) CTGGTC/TTCGAA 1 -- ds50010--------
    rs1505409281,2
    C--120778926(+) TCAATC/TGATCT 1 -- ds50010--------
    rs1394895631,2
    --120778939(+) CCACCC/TCTGCC 1 -- ds50010--------
    rs1156978981,2
    C,F--120779001(+) TTCATC/ATATCT 1 -- ds50013Minor allele frequency- A:0.08WA NA EA 358
    rs1160116651,2
    C,F--120779085(+) GAAAAT/CGAGGT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs47678881,2
    C,H--120779090(+) TGAGGT/GATCCC 1 -- ds50016Minor allele frequency- G:0.00NS EA NA 390

    HapMap Linkage Disequilibrium report for MSI1 (120779133 - 120806983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MSI1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899555CNV Loss21882294
    nsv899556CNV Gain21882294
    esv24462CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603328    OMIM disorders: --

    19 diseases for MSI1:    About MalaCards
    gliosarcoma    malignant glioma    brain ischemia    pick's disease
    melanoma    medulloblastoma    herpes simplex    endometriosis
    ischemia    endometrial carcinoma    glioblastoma    colon cancer
    adenoma    retinitis    alzheimer's disease    lung cancer
    cervicitis    adenocarcinoma    neuronitis


    MSI1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for MSI1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malignant glioma 47.6 4 11284014 (3), 17238803 (1)
    glioblastoma 47.6 2 11284014 (1), 11686236 (1)
    brain tumors 40.6 3 18826648 (1)
    glioma 35.9 7 11686236 (3), 11284014 (2), 16163378 (1)
    tumors 7 17 17627143 (3), 11686236 (3), 11284014 (2), 18419830 (1) (see all 6)
    cancer 0 9 18826648 (3), 11284014 (1), 16955534 (1)


    Export disorders for MSI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSI1 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with MSI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. (PubMed id 9790759)1, 2, 3 Good P.... Okano H. (1998)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    3. Musashi: a translational regulator of cell fate. (PubMed id 11896183)1, 2 Okano H.... Okabe M. (2002)
    4. Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines. (PubMed id 12054577)1, 2 Shu H.-J....Kawata S. (2002)
    5. Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. (PubMed id 18826648)1, 9 Sanchez-Diaz P.C....Penalva L.O. (2008)
    6. Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. (PubMed id 19214660)1, 9 Murayama M....Watanabe M. (2009)
    7. The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. (PubMed id 11359897)1, 9 Imai T....Okano H. (2001)
    8. Expression of the neural RNA-binding protein Musashi1 in human gliomas. (PubMed id 11284014)1, 9 Toda M....Uyemura K. (2001)
    9. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. (PubMed id 18419830)1, 9 Ye F....Chen H. (2008)
    10. Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity. (PubMed id 11686236)1, 9 Kanemura Y....Arita N. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4440 HGNC: 7330 AceView: MSI1 Ensembl:ENSG00000135097 euGenes: HUgn4440
    ECgene: MSI1 Kegg: 4440 H-InvDB: MSI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSI1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSI1 gene:
    Search GeneIP for patents involving MSI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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