MSI1 Gene

Aliases
for MSI1 gene

Previous GC identifers: GC12M119653 GC12M120306 GC12M120561 GC12M119191 GC12M119241 GC12M119263 GC12M117787

Summaries
for MSI1 gene

Genomic Views
for MSI1 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_009775.17  

SwitchGear Promoter luciferase reporter plasmid: MSI1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSI1

MSI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120779:  view genomic region     (about GC identifiers)

Proteins
for MSI1 gene

Explore the universe of human proteins at neXtProt for MSI1: NX_O43347

Post-translational modifications:

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	OriGene Purified Protein: MSI1 OriGene Protein Over-expression Lysate: MSI1 OriGene Custom Protein Services for MSI1
	GenScript Custom Purified and Recombinant Proteins Services for MSI1
	Novus Biologicals MSI1 Protein Novus Biologicals MSI1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MSI1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MSI1
	R&D Systems Antibodies for MSI1 (Musashi-1)
	Cell Signaling Technology (CST) Antibodies for MSI1
	OriGene Antibodies (see all 11): MSI1 OriGene Custom Antibody Services for MSI1
	GenScript Custom Superior Antibodies Services for MSI1
	Novus Biologicals MSI1 Antibodies
	Abcam antibodies for MSI1
	Uscn Antibodies for MSI1
	ThermoFisher Antibody for MSI1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MSI1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MSI1

Protein Domains /
Families
for MSI1 gene

ProtoNet protein and cluster: O43347

Function
for MSI1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSI1
		8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate MSI1 (see all 95):
		hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-607 hsa-miR-1321 hsa-miR-342-3p hsa-miR-149 hsa-miR-3148
		SwitchGear 3'UTR luciferase reporter plasmid: MSI1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSI1 (see all 7) OriGene shRNA RFP: MSI1 OriGene siRNA: MSI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSI1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MSI1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSI1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSI1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MSI1 (NM_002442)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSI1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSI1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MSI1
		Search LifeMap BioReagents cell lines for MSI1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSI1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Msi1)

Pathways & Interactions
for MSI1 gene

	Super-pathway	contained gene-specific pathways
1	Neuroscience	Neuroscience 1.00
2	mRNA surveillance pathway	mRNA surveillance pathway 1.00
3	Wnt / Hedgehog / Notch	Wnt / Hedgehog / Notch 1.00

2 Cell Signaling Technology (CST) Pathways for MSI1

	Wnt / Hedgehog / Notch
	Neuroscience

1         Kegg Pathway  (Kegg details for MSI1)

mRNA surveillance pathway

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for MSI1 gene

Transcripts
for MSI1 gene

Expression
for MSI1 gene

MSI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTTTCGAA

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Neural stem cells (Fetal Stem / Progenitor Cell)			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSI1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSI1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSI1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSI1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSI1

Orthologs
for MSI1 gene

Paralogs
for MSI1 gene

Paralogs for MSI1 gene

HNRNPA3²  DAZAP1²  HNRNPA2B1²  HNRNPA1L2²  HNRNPD²  HNRNPA1²  MSI2²  HNRNPA0²  

HNRNPAB²  HNRPDL²  

13 SIMAP similar genes for MSI1 using alignment to 2 protein entries:     MSI1H_HUMAN (see all proteins):

MSI2    HNRNPA2B1    D10S102    HNRNPAB    HNRPA3    HNRNPA1L2

HNRNPA3    HNRNPD    RBM38    HNRPA1    HNRNPA1    HNRNPA0

DAZAP1

MSI1 for paralogs           About GeneDecksing

Genomic Variants
for MSI1 gene

10/457 NCBI SNPs in MSI1 are shown (see all 457)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs349261251,2	C	--	120778687(+)	TATTCT/-TTTTT	1	--	ds5001		1		NA	2
rs2011172141,2	C	--	120778689(+)	CTATTC/TTTTTT	1	--	ds5001		0	--	--	--	--
rs1830996171,2		--	120778765(+)	CTCACC/TGCAGC	1	--	ds5001		0	--	--	--	--
rs1417284301,2		--	120778906(+)	CTGGTC/TTCGAA	1	--	ds5001		0	--	--	--	--
rs1505409281,2		--	120778926(+)	TCAATC/TGATCT	1	--	ds5001		0	--	--	--	--
rs1394895631,2		--	120778939(+)	CCACCC/TCTGCC	1	--	ds5001		0	--	--	--	--
rs1156978981,2	F,	--	120779001(+)	TTCATC/ATATCT	1	--	ds5001		3		WA NA EA	358
rs1160116651,2		--	120779085(+)	GAAAAT/CGAGGT	1	--	ds5001		1		WA	118
rs47678881,2	C,H	--	120779090(+)	TGAGGT/GATCCC	1	--	ds5001		6		NS EA NA	390
rs110650891,2		--	120779313(+)	GTCCTA/GAGCCC	1	--	ut31 ese3		0	--	--	--	--

HapMap Linkage Disequilibrium report for MSI1 (120779133 - 120806983 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MSI1
     1 CNV: 66344

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSI1

DNA2.0 Custom Variant and Variant Library Synthesis for MSI1

Disorders / Diseases
for MSI1 gene

20/21 diseases for MSI1

6 Novoseek disease relationships for MSI1 gene    About this table

Publications
for MSI1 gene

PubMed articles for MSI1 gene, integrated from 9 sources (see all 65): (articles sorted by number of sources associating them with MSI1)

Utopia: connect your pdf to the dynamic world of online information

1. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. (PubMed id 9790759)^{1, 2, 3} Good P.... Okano H. (1998)
2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (2006)
3. Musashi: a translational regulator of cell fate. (PubMed id 11896183)^{1, 2} Okano H.... Okabe M. (2002)
4. Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines. (PubMed id 12054577)^{1, 2} Shu H.-J....Kawata S. (2002)
5. Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. (PubMed id 18826648)^{1, 9} Sanchez-Diaz P.C....Penalva L.O. (2008)
6. Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. (PubMed id 19214660)^{1, 9} Murayama M....Watanabe M. (2009)
7. The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. (PubMed id 11359897)^{1, 9} Imai T....Okano H. (2001)
8. Expression of the neural RNA-binding protein Musashi1 in human gliomas. (PubMed id 11284014)^{1, 9} Toda M....Uyemura K. (2001)
9. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. (PubMed id 18419830)^{1, 9} Ye F....Chen H. (2008)
10. Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity. (PubMed id 11686236)^{1, 9} Kanemura Y....Arita N. (2001)

External Searches for MSI1 gene

Genome Databases showing MSI1 gene

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Specialized Databases showing MSI1 gene

Products
for MSI1 gene