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Aliases for MSI1 Gene

Aliases for MSI1 Gene

  • Musashi RNA Binding Protein 1 2 3 5
  • Musashi-1 3 4
  • Musashi (Drosophila) Homolog 1 2
  • Musashi Homolog 1 (Drosophila) 2
  • Musashi RNA-Binding Protein 1 3
  • Musashi1 3

External Ids for MSI1 Gene

Previous GeneCards Identifiers for MSI1 Gene

  • GC12M119653
  • GC12M120306
  • GC12M120561
  • GC12M119191
  • GC12M119241
  • GC12M119263
  • GC12M120779
  • GC12M117787

Summaries for MSI1 Gene

Entrez Gene Summary for MSI1 Gene

  • This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSI1 Gene

MSI1 (Musashi RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with MSI1 include Gliosarcoma. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Wnt / Hedgehog / Notch. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DAZAP1.

UniProtKB/Swiss-Prot for MSI1 Gene

  • RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5-GUUAGUUAGUUAGUU-3 and other sequences containing the pattern 5-[GA]U(1-3)AGU-3. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

Gene Wiki entry for MSI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSI1 Gene

Genomics for MSI1 Gene

Regulatory Elements for MSI1 Gene

Enhancers for MSI1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MSI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MSI1 Gene

Chromosome:
12
Start:
120,339,650 bp from pter
End:
120,369,180 bp from pter
Size:
29,531 bases
Orientation:
Minus strand

Genomic View for MSI1 Gene

Genes around MSI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSI1 Gene

Proteins for MSI1 Gene

  • Protein details for MSI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43347-MSI1H_HUMAN
    Recommended name:
    RNA-binding protein Musashi homolog 1
    Protein Accession:
    O43347
    Secondary Accessions:
    • Q96PU0
    • Q96PU1
    • Q96PU2
    • Q96PU3

    Protein attributes for MSI1 Gene

    Size:
    362 amino acids
    Molecular mass:
    39125 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MSI1 Gene

Proteomics data for MSI1 Gene at MOPED

Post-translational modifications for MSI1 Gene

  • Ubiquitination at Lys 76
  • Modification sites at PhosphoSitePlus

Other Protein References for MSI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MSI1 (Musashi-1)

No data available for DME Specific Peptides for MSI1 Gene

Domains & Families for MSI1 Gene

Gene Families for MSI1 Gene

Protein Domains for MSI1 Gene

Suggested Antigen Peptide Sequences for MSI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43347

UniProtKB/Swiss-Prot:

MSI1H_HUMAN :
  • The first RNA recognition motif binds more strongly to RNA compared to the second one.
  • Belongs to the Musashi family.
Domain:
  • The first RNA recognition motif binds more strongly to RNA compared to the second one.
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the Musashi family.
genes like me logo Genes that share domains with MSI1: view

Function for MSI1 Gene

Molecular function for MSI1 Gene

GENATLAS Biochemistry:
Musahi (Drosophila) homolog 1,39kDa,neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells,with an alternatively spliced isoform
UniProtKB/Swiss-Prot Function:
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5-GUUAGUUAGUUAGUU-3 and other sequences containing the pattern 5-[GA]U(1-3)AGU-3. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

Gene Ontology (GO) - Molecular Function for MSI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS 9790759
GO:0008266 poly(U) RNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MSI1: view
genes like me logo Genes that share phenotypes with MSI1: view

Animal Models for MSI1 Gene

MGI Knock Outs for MSI1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSI1 Gene

Localization for MSI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSI1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSI1 Gene COMPARTMENTS Subcellular localization image for MSI1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for MSI1 Gene

Pathways & Interactions for MSI1 Gene

genes like me logo Genes that share pathways with MSI1: view

Pathways by source for MSI1 Gene

SIGNOR curated interactions for MSI1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MSI1 Gene

None

Drugs & Compounds for MSI1 Gene

No Compound Related Data Available

Transcripts for MSI1 Gene

Unigene Clusters for MSI1 Gene

Musashi RNA-binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSI1 Gene

No ASD Table

Relevant External Links for MSI1 Gene

GeneLoc Exon Structure for
MSI1
ECgene alternative splicing isoforms for
MSI1

Expression for MSI1 Gene

mRNA expression in normal human tissues for MSI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSI1 Gene

This gene is overexpressed in Testis (x6.1) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for MSI1 Gene

This gene is overexpressed in Retina (47.3) and Fetal Brain (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSI1 Gene



SOURCE GeneReport for Unigene cluster for MSI1 Gene Hs.158311

mRNA Expression by UniProt/SwissProt for MSI1 Gene

O43347-MSI1H_HUMAN
Tissue specificity: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
genes like me logo Genes that share expression patterns with MSI1: view

Protein tissue co-expression partners for MSI1 Gene

Primer Products

Orthologs for MSI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MSI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MSI1 35
  • 95.86 (n)
  • 100 (a)
MSI1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSI1 35
  • 95.67 (n)
  • 99.72 (a)
MSI1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msi1 35
  • 93.28 (n)
  • 99.45 (a)
Msi1 16
Msi1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MSI1 35
  • 99.69 (n)
  • 100 (a)
MSI1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msi1 35
  • 94.01 (n)
  • 99.72 (a)
oppossum
(Monodelphis domestica)
Mammalia MSI1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSI1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSI1 35
  • 80.57 (n)
  • 92.72 (a)
MSI1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSI1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msi1 35
  • 79.8 (n)
  • 95 (a)
Str.3045 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.836 35
zebrafish
(Danio rerio)
Actinopterygii msi1 35
  • 77.98 (n)
  • 88.79 (a)
msi1 36
  • 85 (a)
OneToMany
MSI1 (2 of 2) 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta msi 37
  • 58 (a)
sqd 37
  • 41 (a)
Rbp6 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea msi-1 37
  • 58 (a)
msi-1 36
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for MSI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSI1 Gene

ENSEMBL:
Gene Tree for MSI1 (if available)
TreeFam:
Gene Tree for MSI1 (if available)

Paralogs for MSI1 Gene

Paralogs for MSI1 Gene

(13) SIMAP similar genes for MSI1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MSI1: view

Variants for MSI1 Gene

Sequence variations from dbSNP and Humsavar for MSI1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_035485 A breast cancer sample
rs10849743 -- 120,351,211(+) CAGTC(G/T)GCTGT intron-variant
rs12818683 -- 120,343,275(+) catag(G/T)tcact intron-variant
rs12818684 -- 120,343,276(+) atagt(G/T)cactg intron-variant
rs2238158 -- 120,343,943(+) CCTTC(C/G)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSI1 Gene

Variant ID Type Subtype PubMed ID
nsv899555 CNV Loss 21882294
nsv899556 CNV Gain 21882294
esv24462 CNV Gain 19812545

Variation tolerance for MSI1 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MSI1 Gene

Disorders for MSI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MSI1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search MSI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MSI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSI1
genes like me logo Genes that share disorders with MSI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSI1 Gene

Publications for MSI1 Gene

  1. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. (PMID: 9790759) Good P. … Okano H. (Genomics 1998) 2 3 4 67
  2. Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. (PMID: 19214660) Murayama M. … Watanabe M. (J. Gastroenterol. 2009) 3 23
  3. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. (PMID: 18419830) Ye F. … Chen H. (BMC Cancer 2008) 3 23
  4. Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. (PMID: 18826648) Sanchez-Diaz P.C. … Penalva L.O. (BMC Cancer 2008) 3 23
  5. The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1. (PMID: 16214366) Battelli C. … Verdi J.M. (Mol. Cell. Neurosci. 2006) 3 23

Products for MSI1 Gene

Sources for MSI1 Gene

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