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Aliases for MSI1 Gene

Aliases for MSI1 Gene

  • Musashi RNA-Binding Protein 1 2 3
  • Musashi-1 3 4
  • RNA-Binding Protein Musashi Homolog 1 3
  • Musashi (Drosophila) Homolog 1 2
  • Musashi Homolog 1 (Drosophila) 2
  • Musashi1 3

External Ids for MSI1 Gene

Summaries for MSI1 Gene

Entrez Gene Summary for MSI1 Gene

  • This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSI1 Gene

MSI1 (Musashi RNA-Binding Protein 1) is a Protein Coding gene. Diseases associated with MSI1 include malignant glioma. Among its related pathways are Wnt / Hedgehog / Notch and Neuroscience. GO annotations related to this gene include RNA binding and poly(U) RNA binding. An important paralog of this gene is DAZAP1.

UniProtKB/Swiss-Prot for MSI1 Gene

  • RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5-GUUAGUUAGUUAGUU-3 and other sequences containing the pattern 5-[GA]U(1-3)AGU-3. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

Gene Wiki entry for MSI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSI1 Gene

Genomics for MSI1 Gene

Genomic Location for MSI1 Gene

Start:
120,341,330 bp from pter
End:
120,369,180 bp from pter
Size:
27,851 bases
Orientation:
Minus strand

Genomic View for MSI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSI1 Gene

Regulatory Elements for MSI1 Gene

Proteins for MSI1 Gene

  • Protein details for MSI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43347-MSI1H_HUMAN
    Recommended name:
    RNA-binding protein Musashi homolog 1
    Protein Accession:
    O43347
    Secondary Accessions:
    • Q96PU0
    • Q96PU1
    • Q96PU2
    • Q96PU3

    Protein attributes for MSI1 Gene

    Size:
    362 amino acids
    Molecular mass:
    39125 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MSI1 Gene

Proteomics data for MSI1 Gene at MOPED

Post-translational modifications for MSI1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys76

Other Protein References for MSI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSI1 Gene

Domains for MSI1 Gene

Gene Families for MSI1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for MSI1 Gene

UniProtKB/Swiss-Prot:

MSI1H_HUMAN
Domain:
  • The first RNA recognition motif binds more strongly to RNA compared to the second one.:
    • O43347
  • Contains 2 RRM (RNA recognition motif) domains.:
    • O43347
Family:
  • Belongs to the Musashi family.:
    • O43347
genes like me logo Genes that share domains with MSI1: view

Function for MSI1 Gene

Molecular function for MSI1 Gene

GENATLAS Biochemistry: Musahi (Drosophila) homolog 1,39kDa,neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells,with an alternatively spliced isoform
UniProtKB/Swiss-Prot Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5-GUUAGUUAGUUAGUU-3 and other sequences containing the pattern 5-[GA]U(1-3)AGU-3. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

Gene Ontology (GO) - Molecular Function for MSI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 9790759
GO:0003727 single-stranded RNA binding --
GO:0008266 poly(U) RNA binding IEA --
genes like me logo Genes that share ontologies with MSI1: view
genes like me logo Genes that share phenotypes with MSI1: view

Animal Models for MSI1 Gene

MGI Knock Outs for MSI1:

miRNA for MSI1 Gene

miRTarBase miRNAs that target MSI1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MSI1 Gene

Localization for MSI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSI1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSI1 Gene COMPARTMENTS Subcellular localization image for MSI1 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MSI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IEA --
genes like me logo Genes that share ontologies with MSI1: view

Pathways for MSI1 Gene

genes like me logo Genes that share pathways with MSI1: view

Pathways by source for MSI1 Gene

2 Cell Signaling Technology pathways for MSI1 Gene
1 KEGG pathway for MSI1 Gene

Gene Ontology (GO) - Biological Process for MSI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9790759
GO:0009725 response to hormone IEA --
GO:0030855 epithelial cell differentiation IEA --
genes like me logo Genes that share ontologies with MSI1: view

Transcripts for MSI1 Gene

Unigene Clusters for MSI1 Gene

Musashi RNA-binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSI1 Gene

No ASD Table

Relevant External Links for MSI1 Gene

GeneLoc Exon Structure for
MSI1
ECgene alternative splicing isoforms for
MSI1

Expression for MSI1 Gene

mRNA expression in normal human tissues for MSI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSI1 Gene

This gene is overexpressed in Testis (6.1) and Pituitary (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSI1 Gene

SOURCE GeneReport for Unigene cluster for MSI1 Gene Hs.158311

mRNA Expression by UniProt/SwissProt for MSI1 Gene

O43347-MSI1H_HUMAN
Tissue specificity: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
genes like me logo Genes that share expressions with MSI1: view

Orthologs for MSI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MSI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSI1 36
  • 99.69 (n)
  • 100 (a)
MSI1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSI1 36
  • 95.86 (n)
  • 100 (a)
MSI1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSI1 36
  • 95.67 (n)
  • 99.72 (a)
MSI1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msi1 36
  • 93.28 (n)
  • 99.45 (a)
Msi1 16
Msi1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSI1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSI1 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msi1 36
  • 94.01 (n)
  • 99.72 (a)
chicken
(Gallus gallus)
Aves MSI1 36
  • 80.57 (n)
  • 92.72 (a)
MSI1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSI1 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.836 36
tropical clawed frog
(Silurana tropicalis)
Amphibia msi1 36
  • 79.8 (n)
  • 95 (a)
Str.3045 36
zebrafish
(Danio rerio)
Actinopterygii msi1 36
  • 77.98 (n)
  • 88.79 (a)
msi1 37
  • 85 (a)
OneToMany
MSI1 (2 of 2) 37
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rbp6 37
  • 36 (a)
OneToMany
msi 38
  • 58 (a)
sqd 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea msi-1 37
  • 51 (a)
OneToMany
msi-1 38
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToMany
Species with no ortholog for MSI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSI1 Gene

ENSEMBL:
Gene Tree for MSI1 (if available)
TreeFam:
Gene Tree for MSI1 (if available)

Paralogs for MSI1 Gene

Paralogs for MSI1 Gene

Selected SIMAP similar genes for MSI1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MSI1: view

Variants for MSI1 Gene

Sequence variations from dbSNP and Humsavar for MSI1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs735382 -- 120,362,522(+) GGGGG(A/G)TGCTC intron-variant, upstream-variant-2KB
rs757122 -- 120,347,793(+) CCAAA(C/G)CTCAT intron-variant
rs757123 -- 120,363,020(+) GCAGC(A/G)AGCGC intron-variant, upstream-variant-2KB
rs916842 -- 120,354,918(+) gctgg(C/G)catgg intron-variant
rs1007469 -- 120,353,239(+) GAGAA(A/G)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MSI1 Gene

Variant ID Type Subtype PubMed ID
nsv899555 CNV Loss 21882294
nsv899556 CNV Gain 21882294
esv24462 CNV Gain 19812545

Relevant External Links for MSI1 Gene

HapMap Linkage Disequilibrium report
MSI1

Disorders for MSI1 Gene

(1) MalaCards Diseases for MSI1 Gene

Search for MSI1 Gene in MalaCards »

(6) Novoseek inferred disease relationships for MSI1 Gene

Disease -log(P) Hits PubMed IDs
malignant glioma 47.6 4
glioblastoma 47.6 2
brain tumors 40.6 1
glioma 35.9 6
tumors 7 11
genes like me logo Genes that share disorders with MSI1: view

No data available for UniProtKB/Swiss-Prot for MSI1 Gene

Publications for MSI1 Gene

  1. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. (PMID: 9790759) Good P. … Okano H. (Genomics 1998) 2 3 4
  2. Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. (PMID: 18826648) Sanchez-Diaz P.C. … Penalva L.O. (BMC Cancer 2008) 3 23
  3. Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines. (PMID: 12054577) Shu H.-J. … Kawata S. (Biochem. Biophys. Res. Commun. 2002) 3 4
  4. Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease. (PMID: 16106215) Lovell M.A. … Markesbery W.R. (J. Neuropathol. Exp. Neurol. 2005) 3 23
  5. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. (PMID: 18419830) Ye F. … Chen H. (BMC Cancer 2008) 3 23

Products for MSI1 Gene

Sources for MSI1 Gene

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