Aliases for MSI1 Gene
External Ids for MSI1 Gene
Previous GeneCards Identifiers for MSI1 Gene
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
GeneCards Summary for MSI1 Gene
MSI1 (Musashi RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with MSI1 include Malignant Glioma and In Situ Pulmonary Adenocarcinoma. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MSI2.
UniProtKB/Swiss-Prot for MSI1 Gene
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5-GUUAGUUAGUUAGUU-3 and other sequences containing the pattern 5-[GA]U(1-3)AGU-3. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).