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MSI1 Gene

protein-coding   GIFtS: 63
GCID: GC12M120779

Musashi RNA-Binding Protein 1

(Previous names: Musashi (Drosophila) homolog 1, musashi homolog 1 (Drosophila))
  See MSI1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Musashi RNA-Binding Protein 11 2     musashi12
Musashi (Drosophila) Homolog 11     RNA-Binding Protein Musashi Homolog 12
Musashi Homolog 1 (Drosophila)1     Musashi-13
musashi-12     

External Ids:    HGNC: 73301   Entrez Gene: 44402   Ensembl: ENSG000001350977   OMIM: 6033285   UniProtKB: O433473   

Export aliases for MSI1 gene to outside databases

Previous GC identifers: GC12M119653 GC12M120306 GC12M120561 GC12M119191 GC12M119241 GC12M119263 GC12M117787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSI1 Gene:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other
species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation.
Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in
gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. (provided by RefSeq, Jul 2008)

GeneCards Summary for MSI1 Gene:
MSI1 (musashi RNA-binding protein 1) is a protein-coding gene. Diseases associated with MSI1 include malignant glioma. GO annotations related to this gene include poly(U) RNA binding and RNA binding. An important paralog of this gene is MSI2.

UniProtKB/Swiss-Prot: MSI1H_HUMAN, O43347
Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates
expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other
sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of
stem cells in the central nervous system (By similarity)

Gene Wiki entry for MSI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSI1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   p53   Sox9   E2F-2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSI1 promoter sequence
   Search Chromatin IP Primers for MSI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

MSI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSI1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120779:  view genomic region     (about GC identifiers)

Start:
120,779,133 bp from pter      End:
120,806,983 bp from pter
Size:
27,851 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MSI1H_HUMAN, O43347 (See protein sequence)
Recommended Name: RNA-binding protein Musashi homolog 1  
Size: 362 amino acids; 39125 Da
Secondary accessions: Q96PU0 Q96PU1 Q96PU2 Q96PU3

Explore the universe of human proteins at neXtProt for MSI1: NX_O43347

Explore proteomics data for MSI1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys76
  • Modification sites at PhosphoSitePlus

  • See MSI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002433.1  
    ENSEMBL proteins: 
     ENSP00000257552   ENSP00000446710  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O43347

    ProtoNet protein and cluster: O43347

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: MSI1H_HUMAN, O43347
    Domain: The first RNA recognition motif binds more strongly to RNA compared to the second one (By similarity)
    Similarity: Belongs to the Musashi family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with MSI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSI1H_HUMAN, O43347
    Function: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates
    expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other
    sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of
    stem cells in the central nervous system (By similarity)

         Genatlas biochemistry entry for MSI1:
    Musahi (Drosophila) homolog 1,39kDa,neural RNA-binding protein putatively expressed in CNS stem cells and neural
    progenitor cells,with an alternatively spliced isoform

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS9790759
    GO:0003727single-stranded RNA binding ----
    GO:0008266poly(U) RNA binding IEA--
         
    Find genes that share ontologies with MSI1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MSI1:
     Decreased cilium length after  

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Msi1):
     behavior/neurological  cardiovascular system  craniofacial  homeostasis/metabolism  mortality/aging 
     nervous system  normal  skeleton 

    Find genes that share phenotypes with MSI1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Msi1tm1Okn for MSI1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSI1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MSI1

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSI1

    miRNA
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    miRTarBase miRNAs that target MSI1:
    hsa-let-7b-5p (MIRT052295), hsa-mir-197-3p (MIRT048066)

    Block miRNA regulation of human, mouse, rat MSI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSI1 (see all 95):
    hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-607 hsa-miR-1321 hsa-miR-342-3p hsa-miR-149 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidMSI1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MSI1

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    Browse Sino Biological Human cDNA Clones
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    eBioscience FlowRNA Probe Sets ( VA1-12257) for MSI1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MSI1H_HUMAN, O43347: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--

    Find genes that share ontologies with MSI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MSI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    2Neuroscience
    Neuroscience
    3mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with MSI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for MSI1
        Wnt / Hedgehog / Notch
    Neuroscience


    1 Kegg Pathway  (Kegg details for MSI1):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSI1
    Interactions:

        Search GeneGlobe Interaction Network for MSI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MSI1 (O433472, 3 ENSP000002575524) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNMA1Q8ND902, 3, ENSP000003189144MINT-64999 I2D: score=4 STRING: ENSP00000318914
    CAMKK2Q96RR43I2D: score=1 
    CLN3Q132863I2D: score=1 
    PKP3Q9Y4463I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS9790759
    GO:0009725response to hormone IEA--
    GO:0030855epithelial cell differentiation IEA--

    Find genes that share ontologies with MSI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSI1 (MSI1H)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MSI1 gene: 
    NM_002442.3  

    Unigene Cluster for MSI1:

    Musashi RNA-binding protein 1
    Hs.158311  [show with all ESTs]
    Unigene Representative Sequence: NM_002442
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257552(uc001tye.1) ENST00000546985 ENST00000546622
    miRNA
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    Block miRNA regulation of human, mouse, rat MSI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MSI1 (see all 95):
    hsa-miR-124* hsa-miR-411* hsa-miR-576-3p hsa-miR-607 hsa-miR-1321 hsa-miR-342-3p hsa-miR-149 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidMSI1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB012851.1 AB072590.1 AB072591.1 AB072592.1 AB073212.1 AK023262.1 

    4 DOTS entries:

    DT.92062855  DT.97772555  DT.97834650  DT.97836642 

    Selected AceView cDNA sequences (see all 36):

    BM313429 BM696052 AI583233 AW770583 BM715963 BX282129 BM684276 BM701308 
    AL040010 NM_002442 AK023262 H42504 BX098565 AB072592 AB072590 BX404216 
    CK822013 AU132470 AA084640 AB012851 AB072591 AB073212 BQ638220 BM664564 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTTCGAA
    MSI1 Expression
    About this image


    MSI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Ectoderm (Nervous System)
             Neural stem cells
     
     Spinal Cord (Nervous System)
             Neural stem cells
     
     Heart (Cardiovascular System)
             Cardiac progenitor cells (Sca1+)
     
     NULL (Uncategorized)
             Neural precursor cells
     
     Eye (Sensory Organs)
    MSI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158311

    UniProtKB/Swiss-Prot: MSI1H_HUMAN, O43347
    Tissue specificity: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in
    hepatoma cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MSI1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msi11 , 5 Musashi homolog 1(Drosophila)5
    musashi RNA-binding protein 11
    93.28(n)1
    99.45(a)1
      5 (56.09 cM)5
    176901  NM_008629.11  NP_032655.11 
     1154295995 
    chicken
    (Gallus gallus)
    Aves MSI11 musashi homolog 1 (Drosophila) 80.57(n)
    92.72(a)
      416979  XM_415271.4  XP_415271.4 
    lizard
    (Anolis carolinensis)
    Reptilia MSI16
    musashi RNA-binding protein 1
    97(a)
    1 ↔ 1
    GL343338.1(26845-50277)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8362 X.laevis nervous system-specific RNA-binding protein more 79.08(n)    M34894.1 
    zebrafish
    (Danio rerio)
    Actinopterygii msi11 musashi homolog 1 (Drosophila) 77.98(n)
    88.79(a)
      541389  NM_001013516.1  NP_001013534.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msi3 mRNA processing RNA binding 58(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea msi-13 RNA binding protein 58(a)   III(4036780-4039221)   --


    ENSEMBL Gene Tree for MSI1 (if available)
    TreeFam Gene Tree for MSI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSI1 gene
    MSI22  TARDBP2  DAZAP12  
    13 SIMAP similar genes for MSI1 using alignment to 2 protein entries:     MSI1H_HUMAN (see all proteins):
    MSI2    HNRNPA2B1    D10S102    HNRNPAB    HNRPA3    HNRNPA1L2
    HNRNPA3    HNRNPD    RBM38    HNRNPA1    HNRPA1    DAZAP1
    HNRNPA0

    Find genes that share paralogs with MSI1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSI1 (see all 572)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354854
    A breast cancer sample4--see VAR_0354852 E Q mis40--------
    rs349261251,2
    C--120778689(+) TATTCT/-TTTTT 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs2011172141,2
    C--120778689(+) CTATTC/TTTTTT 1 -- ds50010--------
    rs1830996171,2
    --120778765(+) CTCACC/TGCAGC 1 -- ds50010--------
    rs1417284301,2
    --120778906(+) CTGGTC/TTCGAA 1 -- ds50010--------
    rs1505409281,2
    C--120778926(+) TCAATC/TGATCT 1 -- ds50010--------
    rs1394895631,2
    --120778939(+) CCACCC/TCTGCC 1 -- ds50010--------
    rs1156978981,2
    C,F--120779001(+) TTCATC/ATATCT 1 -- ds50013Minor allele frequency- A:0.08WA NA EA 358
    rs1160116651,2
    C,F--120779085(+) GAAAAT/CGAGGT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs47678881,2
    C,H--120779090(+) TGAGGT/GATCCC 1 -- ds50016Minor allele frequency- G:0.00NS EA NA 390

    HapMap Linkage Disequilibrium report for MSI1 (120779133 - 120806983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MSI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899555CNV Loss21882294
    nsv899556CNV Gain21882294
    esv24462CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSI1
    DNA2.0 Custom Variant and Variant Library Synthesis for MSI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603328    OMIM disorders: --

    1 disease for MSI1:    
    About MalaCards
    malignant glioma


    Find genes that share disorders with MSI1           About GenesLikeMe

    6 Novoseek inferred disease relationships for MSI1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malignant glioma 47.6 4 11284014 (3), 17238803 (1)
    glioblastoma 47.6 2 11284014 (1), 11686236 (1)
    brain tumors 40.6 3 18826648 (1)
    glioma 35.9 7 11686236 (3), 11284014 (2), 16163378 (1)
    tumors 7 17 17627143 (3), 11686236 (3), 11284014 (2), 18419830 (1) (see all 6)
    cancer 0 9 18826648 (3), 11284014 (1), 16955534 (1)


    Export disorders for MSI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSI1 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with MSI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. (PubMed id 9790759)1, 2, 3 Good P.... Okano H. (Genomics 1998)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    3. Musashi: a translational regulator of cell fate. (PubMed id 11896183)1, 2 Okano H.... Okabe M. (J. Cell Sci. 2002)
    4. Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines. (PubMed id 12054577)1, 2 Shu H.-J....Kawata S. (Biochem. Biophys. Res. Commun. 2002)
    5. Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. (PubMed id 18826648)1, 9 Sanchez-Diaz P.C....Penalva L.O. (BMC Cancer 2008)
    6. Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. (PubMed id 19214660)1, 9 Murayama M....Watanabe M. (J. Gastroenterol. 2009)
    7. The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. (PubMed id 11359897)1, 9 Imai T....Okano H. (Mol. Cell. Biol. 2001)
    8. Expression of the neural RNA-binding protein Musashi1 in human gliomas. (PubMed id 11284014)1, 9 Toda M....Uyemura K. (Glia 2001)
    9. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. (PubMed id 18419830)1, 9 Ye F....Chen H. (BMC Cancer 2008)
    10. Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity. (PubMed id 11686236)1, 9 Kanemura Y....Arita N. ( research in biological diversity 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4440 HGNC: 7330 AceView: MSI1 Ensembl:ENSG00000135097 euGenes: HUgn4440
    ECgene: MSI1 Kegg: 4440 H-InvDB: MSI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSI1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSI1 gene:
    Search GeneIP for patents involving MSI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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