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Aliases for MSI1 Gene

Aliases for MSI1 Gene

  • Musashi RNA Binding Protein 1 2 3 5
  • Musashi-1 3 4
  • RNA-Binding Protein Musashi Homolog 1 3
  • Musashi (Drosophila) Homolog 1 2
  • Musashi Homolog 1 (Drosophila) 2
  • Musashi1 3

External Ids for MSI1 Gene

Previous GeneCards Identifiers for MSI1 Gene

  • GC12M119653
  • GC12M120306
  • GC12M120561
  • GC12M119191
  • GC12M119241
  • GC12M119263
  • GC12M120779
  • GC12M117787

Summaries for MSI1 Gene

Entrez Gene Summary for MSI1 Gene

  • This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSI1 Gene

MSI1 (Musashi RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with MSI1 include Gliosarcoma. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Neuroscience. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MSI2.

UniProtKB/Swiss-Prot for MSI1 Gene

  • RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5-GUUAGUUAGUUAGUU-3 and other sequences containing the pattern 5-[GA]U(1-3)AGU-3. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

Gene Wiki entry for MSI1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSI1 Gene

Genomics for MSI1 Gene

Regulatory Elements for MSI1 Gene

Enhancers for MSI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G120388 1.3 Ensembl ENCODE dbSUPER 17.9 -20.2 -20223 1.6 HINFP SUZ12 ZFP64 MAX ZNF175 ZNF366 POLR2A ZNF600 ZBTB20 ZNF263 MSI1 SIRT4 PLA2G1B ENSG00000111780 COX6A1 RNU6-1088P ENSG00000256695 RPS27P25
GH12G120342 1 ENCODE dbSUPER 18.5 +26.9 26870 0.6 CTCF TFAP4 THRB ZNF48 RARA POLR2A NCOR1 HNF4G NR2F6 ZNF652 MSI1 RPS27P25 RNU6-1088P ENSG00000111780 TRIAP1 RPL31P52 SIRT4 COX6A1 PLA2G1B
GH12G120958 1.6 Ensembl ENCODE dbSUPER 9.4 -591.9 -591894 5.5 HDGF PKNOX1 ARNT CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ACADS C12orf43 SPPL3 OASL ENSG00000256569 ENSG00000255946 UNC119B MLEC ENSG00000256364 P2RX4
GH12G120430 1.2 Ensembl ENCODE 11.9 -61.4 -61384 0.3 ATF1 ARID4B SIN3A ZNF2 ZNF48 CBX5 ZNF207 ZNF143 KLF7 KLF13 RPS27P25 MSI1 RPL31P52 PLA2G1B DYNLL1 SRSF9 RNU6-1088P SIRT4 PXN COX6A1
GH12G120401 0.9 ENCODE dbSUPER 14.4 -33.2 -33231 1.0 L3MBTL2 ZIC2 ZNF121 HIC1 PATZ1 KDM1A ZNF24 ZBTB20 ZNF423 MGA MSI1 ENSG00000256695 COX6A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MSI1 on UCSC Golden Path with GeneCards custom track

Promoters for MSI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058303 280 1401 RBBP5 FOXM1 ZFHX2 GLIS2 EGR1 PATZ1 PRDM10 ZBTB20 EZH2 EGR2

Genomic Location for MSI1 Gene

Chromosome:
12
Start:
120,339,650 bp from pter
End:
120,369,180 bp from pter
Size:
29,531 bases
Orientation:
Minus strand

Genomic View for MSI1 Gene

Genes around MSI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MSI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MSI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSI1 Gene

Proteins for MSI1 Gene

  • Protein details for MSI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43347-MSI1H_HUMAN
    Recommended name:
    RNA-binding protein Musashi homolog 1
    Protein Accession:
    O43347
    Secondary Accessions:
    • Q96PU0
    • Q96PU1
    • Q96PU2
    • Q96PU3

    Protein attributes for MSI1 Gene

    Size:
    362 amino acids
    Molecular mass:
    39125 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MSI1 Gene

Post-translational modifications for MSI1 Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MSI1 Gene

Domains & Families for MSI1 Gene

Gene Families for MSI1 Gene

Suggested Antigen Peptide Sequences for MSI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43347

UniProtKB/Swiss-Prot:

MSI1H_HUMAN :
  • The first RNA recognition motif binds more strongly to RNA compared to the second one.
  • Belongs to the Musashi family.
Domain:
  • The first RNA recognition motif binds more strongly to RNA compared to the second one.
Family:
  • Belongs to the Musashi family.
genes like me logo Genes that share domains with MSI1: view

Function for MSI1 Gene

Molecular function for MSI1 Gene

GENATLAS Biochemistry:
Musahi (Drosophila) homolog 1,39kDa,neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells,with an alternatively spliced isoform
UniProtKB/Swiss-Prot Function:
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5-GUUAGUUAGUUAGUU-3 and other sequences containing the pattern 5-[GA]U(1-3)AGU-3. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

Gene Ontology (GO) - Molecular Function for MSI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22681889
GO:0003727 single-stranded RNA binding IEA --
GO:0008266 poly(U) RNA binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with MSI1: view
genes like me logo Genes that share phenotypes with MSI1: view

Animal Models for MSI1 Gene

MGI Knock Outs for MSI1:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MSI1 Gene

Localization for MSI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSI1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MSI1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MSI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IEA --
genes like me logo Genes that share ontologies with MSI1: view

Pathways & Interactions for MSI1 Gene

genes like me logo Genes that share pathways with MSI1: view

Pathways by source for MSI1 Gene

SIGNOR curated interactions for MSI1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MSI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9790759
genes like me logo Genes that share ontologies with MSI1: view

Drugs & Compounds for MSI1 Gene

No Compound Related Data Available

Transcripts for MSI1 Gene

Unigene Clusters for MSI1 Gene

Musashi RNA-binding protein 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSI1 Gene

No ASD Table

Relevant External Links for MSI1 Gene

GeneLoc Exon Structure for
MSI1
ECgene alternative splicing isoforms for
MSI1

Expression for MSI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MSI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSI1 Gene

This gene is overexpressed in Testis (x6.1) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for MSI1 Gene

This gene is overexpressed in Retina (47.3) and Fetal Brain (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MSI1 Gene



Protein tissue co-expression partners for MSI1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MSI1 Gene:

MSI1

SOURCE GeneReport for Unigene cluster for MSI1 Gene:

Hs.158311

mRNA Expression by UniProt/SwissProt for MSI1 Gene:

O43347-MSI1H_HUMAN
Tissue specificity: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.

Evidence on tissue expression from TISSUES for MSI1 Gene

  • Nervous system(4.4)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with MSI1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MSI1 Gene

Orthologs for MSI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MSI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSI1 34 35
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia MSI1 34 35
  • 95.86 (n)
dog
(Canis familiaris)
Mammalia MSI1 34 35
  • 95.67 (n)
rat
(Rattus norvegicus)
Mammalia Msi1 34
  • 94.01 (n)
mouse
(Mus musculus)
Mammalia Msi1 34 16 35
  • 93.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MSI1 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSI1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MSI1 34 35
  • 80.57 (n)
lizard
(Anolis carolinensis)
Reptilia MSI1 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msi1 34
  • 79.8 (n)
Str.3045 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.836 34
zebrafish
(Danio rerio)
Actinopterygii msi1 34 35
  • 77.98 (n)
MSI1 (2 of 2) 35
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta msi 36
  • 58 (a)
sqd 36
  • 41 (a)
Rbp6 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea msi-1 36 35
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for MSI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSI1 Gene

ENSEMBL:
Gene Tree for MSI1 (if available)
TreeFam:
Gene Tree for MSI1 (if available)

Paralogs for MSI1 Gene

(13) SIMAP similar genes for MSI1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MSI1: view

Variants for MSI1 Gene

Sequence variations from dbSNP and Humsavar for MSI1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_035485 A breast cancer sample
rs1000102146 -- 120,347,053(+) CAAGC(A/G)ATTCT intron-variant
rs1000173275 -- 120,353,002(+) CTGGT(A/G)GAAGT intron-variant
rs1000216424 -- 120,366,741(+) ACAAA(A/G)CCCTG intron-variant
rs1000362790 -- 120,368,485(+) GAGCT(C/G)GGCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MSI1 Gene

Variant ID Type Subtype PubMed ID
esv24462 CNV gain 19812545
esv3549883 CNV deletion 23714750
nsv1071059 CNV deletion 25765185
nsv1110897 OTHER inversion 24896259
nsv1131047 CNV deletion 24896259
nsv560437 CNV loss 21841781

Variation tolerance for MSI1 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MSI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MSI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSI1 Gene

Disorders for MSI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MSI1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search MSI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MSI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MSI1
genes like me logo Genes that share disorders with MSI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MSI1 Gene

Publications for MSI1 Gene

  1. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. (PMID: 9790759) Good P. … Okano H. (Genomics 1998) 2 3 4 64
  2. Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. (PMID: 19214660) Murayama M. … Watanabe M. (J. Gastroenterol. 2009) 3 22 64
  3. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. (PMID: 18419830) Ye F. … Chen H. (BMC Cancer 2008) 3 22 64
  4. Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. (PMID: 18826648) Sanchez-Diaz P.C. … Penalva L.O. (BMC Cancer 2008) 3 22 64
  5. The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1. (PMID: 16214366) Battelli C. … Verdi J.M. (Mol. Cell. Neurosci. 2006) 3 22 64

Products for MSI1 Gene

Sources for MSI1 Gene

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