Aliases for MSH5 Gene
External Ids for MSH5 Gene
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for MSH5 Gene
MSH5 (MutS Homolog 5) is a Protein Coding gene. Diseases associated with MSH5 include common variable immunodeficiency and premature ovarian failure. Among its related pathways are Meiosis and Meiosis. GO annotations related to this gene include DNA-dependent ATPase activity and mismatched DNA binding. An important paralog of this gene is MSH5-SAPCD1.
UniProtKB/Swiss-Prot for MSH5 Gene
Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).