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Aliases & Descriptions for MSH5
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp434C1615 2 G7 2 MGC2939 2 MutSH5 2 NG23 2 OTTHUMP00000029187 2 OTTHUMP00000029188 2
Descriptions mutS (E. coli) homolog 5 1 mutS homolog 5 2 mutS homolog 5 (E. coli) 2
Search outside databases for aliases for MSH5 genePrevious GC identifers: GC06P031771 GC06P031478 GC06P031812
Summaries for MSH5 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MSH5 : This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repairor meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae proteinthat participates in meiotic segregation fidelity and crossing-over. This protein formsheterooligomers with another member of this family, mutS homolog 4. Alternative splicing resultsin four transcript variants encoding three different isoforms. [provided by RefSeq] UniProtKB/Swiss-Prot: MSH5_HUMAN, O43196 Function : Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis(By similarity)
Gene Wiki entry for MSH5
Genomic Location for MSH5
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MSH5 gene Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3 MSH5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P031815:
(about GC identifiers )
Start:
31,815,753 bp from pter
End:
31,838,432 bp from pter
Size:
22,680 bases
Orientation:
plus strand
2 alternative locations : Chr 6+,c6_QBL 31,840,862-31,862,508 Chr 6+,c6_COX 31,842,433-31,865,089
RefSeq DNA sequence: NC_000006.10 NT_007592.14 NT_113891.1 NT_113894.1 Proteins for MSH5
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MSH5_HUMAN, O43196 (See
protein sequence )Recommended Name: MutS protein homolog 5 Size : 834 amino acids; 92875 Da
Subunit : Heterooligomer of MSH4 and MSH5. Interacts with HJURP
Secondary accessions : O60586 Q5BLU9 Q5SSR1 Q8IW44 Q9BQC7Alternative splicing : 4 isoforms : O43196-1 O43196-2 O43196-3 O43196-4
REFSEQ proteins (4 alternative transcripts):
NP_002432.1 NP_079535.3 NP_751897.1 NP_751898.1 ENSEMBL proteins: ENSP00000372893 ENSP00000364848 ENSP00000364892 ENSP00000379194 ENSP00000364908 ENSP00000364894 ENSP00000364855 ENSP00000364903 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for MSH5: Assays for MSH5:
Protein
Domains/ Families for MSH5(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O43196 ProtoNet protein and cluster: O43196
1 Blocks protein family : IPB007696 MutS III UniProtKB/Swiss-Prot: MSH5_HUMAN, O43196 Similarity : Belongs to the DNA mismatch repair mutS family
Gene Function for MSH5
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_025259 Applied Biosystems Silencer ® siRNAs for MSH5 Sigma-Aldrich siRNA and siRNA Panels for MSH5 Sigma-Aldrich shRNA for MSH5 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_002441                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_002441                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_002441  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_025259 UniProtKB/Swiss-Prot: MSH5_HUMAN, O43196 Function : Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis(By similarity)
Genatlas biochemistry entry for MSH5 :yeast meiosis specific protein,mutator gene homolog (bacteria Mut S homolog 5) interacting withMSH4,92.9kDa,ubiquitous,mostly expressed in testis,thymus, and immune system,putatively requiredfor chromosome pairing in meiosis and DNA replicative mismatch repair
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Msh5) :5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
):
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Pathways & Interactions for MSH5
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for MSH5 --5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
):
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Drugs & Compounds for MSH5 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MSH5
Transcripts for MSH5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_025259 Sigma-Aldrich siRNA and siRNA Panels for MSH5 Sigma-Aldrich shRNA for MSH5 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_002441 NM_025259 NM_172165 NM_172166
REFSEQ mRNAs for MSH5 gene (4 alternative transcripts): NM_002441.3 NM_025259.4 NM_172165.2 NM_172166.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002441 NM_025259 NM_172165 NM_172166
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_002441                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_002441                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_002441  
Additional cDNA sequence: AB209886.1 AF034759.1 AF048986.1 AF070071.1 AK303129.1 AK304221.1 BC001358.2 BC002498.2 BC041031.1 BT007200.1
17 DOTS entries : DT.100789192 DT.92429774 DT.121408300 DT.95274369 DT.75102357 DT.100026601 DT.100789187 DT.86857350 DT.121408285 DT.121408310 DT.302179 DT.100687934 DT.100789190 DT.203689 DT.95154171 DT.121408227 DT.97842306
24/185 AceView cDNA sequences (see all 185
):BU950645 AI979234 CA427196 NM_172165 BC041031 BC002498 BI062976 AA588121 BI063399 AF034759 AA317440 AA969618 CD671687 AI796035 AA399986 AL122094 BU951004 AA503388 AI261444 BM764810 CD242818 AA971011 BE276767 AF048986
highest scoring ESTs for MSH5 :AF070071 AA135366 AA470697 AA503388 AA588121 AA621155 AA632264 AA651782 AA775820 AF034759
Unigene Cluster for MSH5: MutS homolog 5 (E. coli) Hs.647011 [show with all ESTs ] Unigene Representative Sequence: AB209886 GeneLoc Exon Structure 8 Ensembl transcripts including schematic representations : ENST00000383401
ENST00000375696
ENST00000375740
ENST00000395853
ENST00000375755
ENST00000375742
ENST00000375703
ENST00000375750
Expression for MSH5
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MSH5 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MSH5 1 / 2 / 3
4 probe-sets matching MSH5 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CCCTCTTTGTSOURCE GeneReport for Unigene cluster: Hs.647011 Expression variation in blood from EXPOLDB for MSH5
UniProtKB/Swiss-Prot: MSH5_HUMAN, O43196 Tissue specificity : Ubiquitous, but highly expressed in testis, and thymus
Orthologs for MSH5
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MSH5 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for MSH5 ENSEMBL Gene Tree for MSH5 Paralogs for MSH5 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MSH5 gene MSH4 2 MSH2 2
SNPs/Variants for MSH5 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MSH5 (up to first 250kb)
Disorders & Mutations for MSH5
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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OMIM: 603382 1 Novoseek disease relationship for MSH5 gene
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
colorectal cancer
26.02
1
9740671 (1)
About this table Human Gene Mutation Database : MSH5 Human Genome Epidemiology Navigator: MSH5 (6 documents)
Medical News for MSH5 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MSH5 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/32 PubMed articles for MSH5 gene (see all 32
): Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene. (PubMed id 9740671) 1, 2, 3, 4 Her C. and Doggett N.A. (1998) Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. (PubMed id 9787078) 1, 2, 3, 4 Winand N.J....Kolodner R.D. (1998) hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery. (PubMed id 17977839) 2, 3 Snowden T....Fishel R. (2008) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 3, 4 Mungall A.J.... Beck S. (2003) Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967) 3, 4 Xie T.... Hood L. (2003) hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis. (PubMed id 10029069) 3, 4 Bocker T.... Fishel R. (1999) Spermatogenesis-specific association of SMCY and MSH5. (PubMed id 18459961) 1, 3 Akimoto C....Kato S. (2008) Genetic investigation of four meiotic genes in women with premature ovarian failure. (PubMed id 18166824) 1, 3 Mandon-Pepin B....Fellous M. (2008) Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1. (PubMed id 12591739) 1, 3 Her C....Zhou F. (2003)
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Genome Databases showing MSH5
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Specialized Databases showing MSH5 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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