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Aliases for MSH5 Gene

Aliases for MSH5 Gene

  • MutS Homolog 5 2 3
  • MutS (E. Coli) Homolog 5 2
  • MutS Homolog 5 (E. Coli) 2
  • MutS Protein Homolog 5 3
  • MUTSH5 3
  • HMSH5 4
  • NG23 3
  • G7 3

External Ids for MSH5 Gene

Summaries for MSH5 Gene

Entrez Gene Summary for MSH5 Gene

  • This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MSH5 Gene

MSH5 (MutS Homolog 5) is a Protein Coding gene. Diseases associated with MSH5 include common variable immunodeficiency and premature ovarian failure. Among its related pathways are Meiosis and Meiosis. GO annotations related to this gene include DNA-dependent ATPase activity and mismatched DNA binding. An important paralog of this gene is MSH5-SAPCD1.

UniProtKB/Swiss-Prot for MSH5 Gene

  • Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).

Gene Wiki entry for MSH5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSH5 Gene

Genomics for MSH5 Gene

Genomic Location for MSH5 Gene

Start:
31,739,948 bp from pter
End:
31,762,834 bp from pter
Size:
22,887 bases
Orientation:
Plus strand

Genomic View for MSH5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for MSH5 Gene

Transcription factor binding sites by QIAGEN in the MSH5 gene promoter:

Proteins for MSH5 Gene

  • Protein details for MSH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43196-MSH5_HUMAN
    Recommended name:
    MutS protein homolog 5
    Protein Accession:
    O43196
    Secondary Accessions:
    • B0V033
    • B0V034
    • O60586
    • Q5BLU9
    • Q5SSR1
    • Q8IW44
    • Q9BQC7

    Protein attributes for MSH5 Gene

    Size:
    834 amino acids
    Molecular mass:
    92875 Da
    Quaternary structure:
    • Heterooligomer of MSH4 and MSH5. Interacts with HJURP.

    Alternative splice isoforms for MSH5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MSH5 Gene

Proteomics data for MSH5 Gene at MOPED

Post-translational modifications for MSH5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys105 and Lys584

No data available for DME Specific Peptides for MSH5 Gene

Domains for MSH5 Gene

UniProtKB/Swiss-Prot:

MSH5_HUMAN
Family:
  • Belongs to the DNA mismatch repair MutS family.:
    • O43196
genes like me logo Genes that share domains with MSH5: view

No data available for Gene Families for MSH5 Gene

Function for MSH5 Gene

Molecular function for MSH5 Gene

GENATLAS Biochemistry: yeast meiosis specific protein,mutator gene homolog (bacteria Mut S homolog 5) interacting with MSH4,92.9kDa,ubiquitous,mostly expressed in testis,thymus, and immune system,putatively required for chromosome pairing in meiosis and DNA replicative mismatch repair
UniProtKB/Swiss-Prot Function: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).

Gene Ontology (GO) - Molecular Function for MSH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 NOT damaged DNA binding IRD --
GO:0005515 protein binding IPI 16397227
GO:0005524 ATP binding IEA --
GO:0008094 DNA-dependent ATPase activity IBA --
GO:0030983 mismatched DNA binding IBA --
genes like me logo Genes that share ontologies with MSH5: view
genes like me logo Genes that share phenotypes with MSH5: view

Animal Models for MSH5 Gene

MGI Knock Outs for MSH5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MSH5 Gene

Localization for MSH5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSH5 Gene COMPARTMENTS Subcellular localization image for MSH5 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MSH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex IBA --
GO:0032300 NOT mismatch repair complex IRD --
genes like me logo Genes that share ontologies with MSH5: view

Pathways for MSH5 Gene

genes like me logo Genes that share pathways with MSH5: view

Pathways by source for MSH5 Gene

1 BioSystems pathway for MSH5 Gene
2 Reactome pathways for MSH5 Gene

Gene Ontology (GO) - Biological Process for MSH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000710 NOT meiotic mismatch repair IRD --
GO:0006200 obsolete ATP catabolic process --
GO:0006298 mismatch repair --
GO:0007131 reciprocal meiotic recombination IBA --
GO:0045143 homologous chromosome segregation IBA --
genes like me logo Genes that share ontologies with MSH5: view

Transcripts for MSH5 Gene

Unigene Clusters for MSH5 Gene

MutS homolog 5 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSH5 Gene

No ASD Table

Relevant External Links for MSH5 Gene

GeneLoc Exon Structure for
MSH5
ECgene alternative splicing isoforms for
MSH5

Expression for MSH5 Gene

mRNA expression in normal human tissues for MSH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MSH5 Gene

SOURCE GeneReport for Unigene cluster for MSH5 Gene Hs.647011

mRNA Expression by UniProt/SwissProt for MSH5 Gene

O43196-MSH5_HUMAN
Tissue specificity: Ubiquitous, but highly expressed in testis, and thymus
genes like me logo Genes that share expressions with MSH5: view

Orthologs for MSH5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSH5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 97 (a)
OneToMany
MSH5 36
  • 99.6 (n)
  • 99.4 (a)
cow
(Bos Taurus)
Mammalia MSH5 36
  • 90.3 (n)
  • 92.55 (a)
MSH5 37
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MSH5 36
  • 88.56 (n)
  • 90.07 (a)
MSH5 37
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Msh5 36
  • 87.09 (n)
  • 89.59 (a)
Msh5 16
Msh5 37
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 70 (a)
ManyToMany
-- 37
  • 60 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Msh5 36
  • 86.63 (n)
  • 88.94 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia msh5 36
  • 61.42 (n)
  • 59.08 (a)
zebrafish
(Danio rerio)
Actinopterygii msh5 36
  • 59.29 (n)
  • 55.37 (a)
MSH5 37
  • 53 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002642 36
  • 46.38 (n)
  • 33.74 (a)
worm
(Caenorhabditis elegans)
Secernentea msh-5 36
  • 42.09 (n)
  • 31.7 (a)
msh-5 37
  • 17 (a)
OneToMany
msh-5 38
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSH5 36
  • 42.96 (n)
  • 33.22 (a)
MSH5 37
  • 24 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16423g 36
  • 40.67 (n)
  • 31.69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MSH5 36
  • 44.12 (n)
  • 33.56 (a)
rice
(Oryza sativa)
Liliopsida Os05g0498300 36
  • 45.43 (n)
  • 34.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09384 36
  • 45.13 (n)
  • 35.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for MSH5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MSH5 Gene

ENSEMBL:
Gene Tree for MSH5 (if available)
TreeFam:
Gene Tree for MSH5 (if available)

Paralogs for MSH5 Gene

Paralogs for MSH5 Gene

genes like me logo Genes that share paralogs with MSH5: view

Variants for MSH5 Gene

Sequence variations from dbSNP and Humsavar for MSH5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_025082 -
VAR_025083 -
VAR_025084 -
VAR_025085 -
VAR_025086 -

Structural Variations from Database of Genomic Variants (DGV) for MSH5 Gene

Variant ID Type Subtype PubMed ID
nsv884418 CNV Gain 21882294
nsv819978 CNV Loss 19587683
dgv6582n71 CNV Loss 21882294
dgv6583n71 CNV Loss 21882294

Relevant External Links for MSH5 Gene

HapMap Linkage Disequilibrium report
MSH5
Human Gene Mutation Database (HGMD)
MSH5

Disorders for MSH5 Gene

(1) University of Copenhagen DISEASES for MSH5 Gene

(1) Novoseek inferred disease relationships for MSH5 Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 24.5 1

Relevant External Links for MSH5

Genetic Association Database (GAD)
MSH5
Human Genome Epidemiology (HuGE) Navigator
MSH5
genes like me logo Genes that share disorders with MSH5: view

No data available for UniProtKB/Swiss-Prot for MSH5 Gene

Publications for MSH5 Gene

  1. Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene. (PMID: 9740671) Her C. … Doggett N.A. (Genomics 1998) 2 3 4 23
  2. Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. (PMID: 9787078) Winand N.J. … Kolodner R.D. (Genomics 1998) 2 3 4 23
  3. Genetic investigation of four meiotic genes in women with premature ovarian failure. (PMID: 18166824) Mandon-PAcpin B. … Fellous M. (Eur. J. Endocrinol. 2008) 3 23 49
  4. Spermatogenesis-specific association of SMCY and MSH5. (PMID: 18459961) Akimoto C. … Kato S. (Genes Cells 2008) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MSH5 Gene

Sources for MSH5 Gene

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