Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSH4 Gene

protein-coding   GIFtS: 59
GCID: GC01P076262

mutS homolog 4 (E. coli)

(Previous name: mutS (E. coli) homolog 4 )
 Explore 11 diseases affiliated with
MSH4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MSH4    

Aliases
for MSH4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MutS Homolog 4 (E. Coli)1 2
HMSH41
MutS (E. Coli) Homolog 41
MutS Protein Homolog 42

External Ids:    HGNC: 73271   Entrez Gene: 44382   Ensembl: ENSG000000574687   OMIM: 6021055   UniProtKB: O154573   

Export aliases for MSH4 gene to outside databases

Previous GC identifers: GC01P076382 GC01P075197 GC01P075678 GC01P075685 GC01P075974 GC01P076035 GC01P074392


Summaries
for MSH4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MSH4:
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is
not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of
homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday
Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between
parental chromosomes during meiosis double-stranded break repair. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457
Function: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous
chromosomes at meiosis

Gene Wiki entry for MSH4


Genomic Views
for MSH4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSH4 gene promoter:
         AML1a   FOXO3   AP-4   E4BP4   C/EBPalpha   Evi-1   FOXO3b   POU2F1   POU2F1a   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MSH4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31

MSH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSH4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P076262:  view genomic region     (about GC identifiers)

Start:
 76,262,567 bp from pter      End:
 76,378,923 bp from pter
Size:
 116,357 bases      Orientation:
 plus strand

Proteins
for MSH4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457 (See protein sequence)
Recommended Name: MutS protein homolog 4  
Size: 936 amino acids; 104756 Da
Subunit: Heterooligomer of MSH4 and MSH5
Secondary accessions: Q5T4U6 Q8NEB3 Q9UNP8

Explore the universe of human proteins at neXtProt for MSH4: NX_O15457

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15457

    • MSH4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002431.2  
    ENSEMBL proteins: 
     ENSP00000263187  
    Reactome Protein details: O15457
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for MSH4 
    GenScript Custom Purified and Recombinant Proteins Services for MSH4
    Novus Biologicals MSH4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MSH4

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793condensed chromosome ----
    GO:0000794condensed nuclear chromosome ----
    GO:0000795synaptonemal complex IBA--
    GO:0005634nucleus TAS9299235
    GO:0032300NOT mismatch repair complex IRD--


    MSH4 for ontologies           About GeneDecksing



    MSH4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MSH4 
    GenScript Custom Superior Antibodies Services for MSH4
    Novus Biologicals MSH4 Antibodies
    Search for Antibodies for MSH4 at Abcam  
    Uscn Antibodies for MSH4
    Search ThermoFisher Antibodies for MSH4

    Assay Products for MSH4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MSH4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MSH4

    Protein Domains /
    Families
    for MSH4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MSH4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR007861 DNA_mismatch_repair_MutS_clamp
     IPR007696 DNA_mismatch_repair_MutS_core
     IPR007860 DNA_mmatch_repair_MutS_con_dom
     IPR000432 DNA_mismatch_repair_MutS_C

    Graphical View of Domain Structure for InterPro Entry O15457

    ProtoNet protein and cluster: O15457

    UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457
    Similarity: Belongs to the DNA mismatch repair MutS family


    Function
    for MSH4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457
    Function: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous
    chromosomes at meiosis

         Genatlas biochemistry entry for MSH4:
    yeast meiosis-specific protein (Mut S homolog 4) expressed in testis and ovary,interacting with MSH5,not involved in
    mismatch repair

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSH4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MSH4:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MSH4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSH4 (see all 7)
    OriGene shRNA RFP: MSH4
    OriGene siRNA: MSH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSH4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MSH4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSH4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSH4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MSH4 (NM_002440)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSH4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MSH4
    Search LifeMap BioReagents cell lines for MSH4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH4

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9299235
    GO:0003684NOT damaged DNA binding IRD--
    GO:0005524ATP binding IEA--
    GO:0008094DNA-dependent ATPase activity IBA--
    GO:0030983mismatched DNA binding IBA--


    MSH4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MSH4:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Msh4tm1Wed for MSH4
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Msh4):
     behavior/neurological  endocrine/exocrine gland  reproductive system 

    MSH4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MSH4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of Meiotic Holliday Junction
    		Formation of Meiotic Holliday Junction1.00
    		Resolution of Meiotic Holliday Junction0.31
    2Meiotic Synapsis
    		Meiosis0.70
    		Meiotic Recombination0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for MSH4
        Resolution of Meiotic Holliday Junction
    Formation of Meiotic Holliday Junction
    Meiosis
    Meiotic Recombination



    MSH4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MSH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/71 Interacting proteins for MSH4 (O154572, 3 ENSP000002631874) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000266442O431962, 3MINT-7158693 MINT-7158702 MINT-7158714 MINT-7158651 I2D: score=9 
    MSH5O431962, 3, ENSP000003648944MINT-7158693 MINT-7158702 MINT-7158714 MINT-7158651 I2D: score=9 STRING: ENSP00000364894
    CALM1P621583I2D: score=2 
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000710NOT meiotic mismatch repair IRD--
    GO:0001541ovarian follicle development IEA--
    GO:0007126meiosis ----
    GO:0007129synapsis ----
    GO:0007131reciprocal meiotic recombination IBA--


    MSH4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MSH4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSH4
    Search CenterWatch for drugs/clinical trials and news about MSH4 

    Transcripts
    for MSH4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MSH4 gene: 
    NM_002440.3  

    Unigene Cluster for MSH4:

    MutS homolog 4 (E. coli)
    Hs.216639  [show with all ESTs]
    Unigene Representative Sequence: NM_002440
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263187(uc001dhd.2)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSH4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MSH4:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MSH4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSH4 (see all 7)
    OriGene shRNA RFP: MSH4
    OriGene siRNA: MSH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSH4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSH4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSH4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MSH4 (NM_002440)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSH4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSH4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSH4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSH4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSH4

    Additional cDNA sequence: 

    AF104243.1 AJ844635.1 BC033030.1 U89293.1 

    2 DOTS entries:

    DT.91721028  DT.451554 

    18 AceView cDNA sequences:

    NM_002440 AF104243 BX115943 AA300472 BC033030 CB858032 BF980010 U89293 
    BG037183 BI460509 BI560598 BG190519 BG205338 BG194576 BG197567 BG213204 
    BG216974 AA868028 

    GeneLoc Exon Structure


    Expression
    for MSH4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTTTGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MSH4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MSH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSH4

    SOURCE GeneReport for Unigene cluster: Hs.216639

    UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457
    Tissue specificity: Testis and ovary specific

        SABiosciences Expression via Pathway-Focused PCR Array including MSH4: 
              DNA Repair in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSH4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSH4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSH4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSH4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH4

    Orthologs
    for MSH4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MSH4 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MSH41 mutS homolog 4 (E. coli) 78.22(n)
    82.86(a)    		   424725  XM_422549.3  XP_422549.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MSH46
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343194.1(3378016-3402931)
    zebrafish
    (Danio rerio)    		 Actinopterygii msh41 mutS homolog 4 (E. coli) 59.75(n)
    60.76(a)    		   559917  XM_683314.4  XP_688406.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 14(a)
    		 1 ↔ 1
    		 Group11.1(65719-71472)
    worm
    (Caenorhabditis elegans)    		 Secernentea him-141 , 3 recombiation protein3
    Protein HIM-141    		 31(a)3
    45.97(n)1
    33.15(a)1    		   II(7065050-7069898)3
    1741571  NM_063050.41  NP_495451.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes MSH41 Msh4p 48.51(n)
    33.57(a)    		   850545   NP_116652.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MSH41 DNA mismatch repair protein MSH4 47.61(n)
    37.63(a)    		   827450  NM_117842.3  NP_193469.2 
    rice
    (Oryza sativa)    		 Liliopsida Os07g04860001 hypothetical protein 46.05(n)
    33.02(a)    		   9266513  NM_001188272.1  NP_001175201.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria mutS6
    		 methyl-directed mismatch repair protein
    		 21(a)
    		 possible ortholog
    		 Chromosome(2855115-2857676)


    ENSEMBL Gene Tree for MSH4 (if available)
    TreeFam Gene Tree for MSH4 (if available) 

    Paralogs
    for MSH4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MSH4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2233 NCBI SNPs in MSH4 are shown (see all 2233)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2012775921,2
    		C--74390408(+) GTTATG/TTTCAA 2 -- us2k1 ut310--------
    rs170975431,2
    		C,F,H,--74390486(+) GTTCTA/GTAGCA 2 -- us2k1 ut3111Minor allele frequency- G:0.04NA NS EA WA 1346
    rs749665731,2
    		C,F,--74390632(+) CTGAAT/ATGGTC 2 -- us2k1 int11Minor allele frequency- A:0.04WA 118
    rs11466411,2
    		C,F,--74390908(-) tgctgC/Ggctcc 2 -- us2k1 int16Minor allele frequency- G:0.33NA WA CSA 127
    rs799661891,2
    		C,--74390942(+) CCTCCG/ATCTGC 2 -- us2k1 int11Minor allele frequency- A:0.50WA 2
    rs115794651,2
    		H--74391101(+) cacctC/Tggcct 1 -- us2k10--------
    rs768182451,2
    		C,F,--74391169(+) TCACTC/TTAGGG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs57453091,2
    		C,F,H,--74391744(+) CATGTT/GTAATC 1 -- us2k122Minor allele frequency- G:0.10NS NA EA WA CSA 2165
    rs81794981,2
    		C,H--74392027(+) CCTTAG/AGTGGG 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs120215341,2
    		C,H--74392389(+) TTAGTG/ACGTCG 1 -- ut514Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for MSH4 (76262567 - 76378923 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MSH4
         2 CNVs: 97403 97404
         1 Indel: 24267
    Human Gene Mutation Database (HGMD): MSH4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSH4
    DNA2.0 Custom Variant and Variant Library Synthesis for MSH4

    Disorders / Diseases
    for MSH4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MSH4 for disorders           About GeneDecksing

    OMIM gene information: 602105    OMIM disorders: --

    11 diseases for MSH4:    About MalaCards
    premature ovarian failure    breast cancer susceptibility    male infertility    epithelial ovarian cancer
    breast cancer    ovarian cancer    infertility    azoospermia
    conjunctivitis    meningioma    pneumonia

    Human Genome Epidemiology (HuGE) Navigator: MSH4 (6 documents)

    Export disorders for MSH4 gene to outside databases

    Publications
    for MSH4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSH4 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with MSH4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene. (PubMed id 9299235)1, 2, 3, 9 Paquis-Flucklinger V.... Desnuelle C. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. MSH4 acts in conjunction with MLH1 during mammalian meiosis. (PubMed id 10928988)1, 9 Santucci-Darmanin S....Paquis-Flucklinger V. (2000)
    4. Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1. (PubMed id 12591739)1, 9 Her C....Zhou F. (2003)
    5. Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. (PubMed id 9787078)1, 9 Winand N.J.... Kolodner R.D. (1998)
    6. Mutation analysis of three genes in patients with mat uration arrest of spermatogenesis and couples with recurrent miscarriages. (PubMed id 21126912)1 Stouffs K....Lissens W. (2011)
    7. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1 Aston K.I....Carrell D.T. (2010)
    8. Genetic investigation of four meiotic genes in women with premature ovarian failure. (PubMed id 18166824)1 Mandon-Pepin B....Fellous M. (2008)
    9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1 Palmieri R.T.... . (2008)
    10. hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery. (PubMed id 17977839)1 Snowden T....Fishel R. (2008)

    External Searches for MSH4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MSH4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4438 HGNC: 7327 AceView: MSH4 Ensembl:ENSG00000057468 euGenes: HUgn4438
    ECgene: MSH4 H-InvDB: MSH4

    Other Databases showing MSH4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MSH4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSH4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSH4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/msh4/

    Intellectual Property
    for MSH4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MSH4 gene:
    Search GeneIP for patents involving MSH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MSH4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MSH4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSH4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSH4  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MSH4   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSH4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSH4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MSH4   OriGene Custom Protein Services for MSH4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MSH4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSH4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSH4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSH4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSH4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSH4
     GenScript Custom Purified and Recombinant Proteins Services for MSH4 GenScript cDNA clones with any tag delivered in your preferred vector for MSH4
     GenScript Custom Assay Services for MSH4 GenScript Custom Superior Antibodies Services for MSH4
     GenScript Custom overexpressing Cell Line Services for MSH4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MSH4 promoter
     Search Chromatin IP Primers for MSH4
     RT2 qPCR Primer Assay in human, mouse, rat MSH4
     GNC Network for MSH4
     SABiosciences PCR Arrays including human, mouse, rat MSH4
     Search Tocris compounds for MSH4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MSH4 antibodies
     MSH4 proteins
     Search for Antibodies for MSH4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MSH4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MSH4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MSH4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH4
     SwitchGear 3'UTR luciferase reporter plasmids for MSH4
     SwitchGear Promoter luciferase reporter plasmids for MSH4
     Search ThermoFisher Antibodies for MSH4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSH4
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MSH4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4