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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSH4 Gene

protein-coding   GIFtS: 60
GCID: GC01P076262

MutS Homolog 4

(Previous names: mutS (E. coli) homolog 4, mutS homolog 4 (E. coli))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MutS Homolog 41
MutS Homolog 4 (E. Coli)1 2
hMSH42 3
MutS (E. Coli) Homolog 41
MutS Protein Homolog 42

External Ids:    HGNC: 73271   Entrez Gene: 44382   Ensembl: ENSG000000574687   OMIM: 6021055   UniProtKB: O154573   

Export aliases for MSH4 gene to outside databases

Previous GC identifers: GC01P076382 GC01P075197 GC01P075678 GC01P075685 GC01P075974 GC01P076035 GC01P074392


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MSH4 Gene:
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that
is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation
of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a
Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the
interaction between parental chromosomes during meiosis double-stranded break repair. (provided by RefSeq, Aug
2011)

GeneCards Summary for MSH4 Gene: 
MSH4 (mutS homolog 4) is a protein-coding gene. Diseases associated with MSH4 include premature ovarian failure, and breast cancer susceptibility, and among its related super-pathways are Meiosis. GO annotations related to this gene include mismatched DNA binding and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457
Function: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of
homologous chromosomes at meiosis

Gene Wiki entry for MSH4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSH4 gene promoter:
         AML1a   FOXO3   AP-4   E4BP4   C/EBPalpha   Evi-1   FOXO3b   POU2F1   POU2F1a   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MSH4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MSH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31

MSH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSH4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P076262:  view genomic region     (about GC identifiers)

Start:
76,262,567 bp from pter      End:
76,378,923 bp from pter
Size:
116,357 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457 (See protein sequence)
Recommended Name: MutS protein homolog 4  
Size: 936 amino acids; 104756 Da
Subunit: Heterooligomer of MSH4 and MSH5
Secondary accessions: Q5T4U6 Q8NEB3 Q9UNP8

Explore the universe of human proteins at neXtProt for MSH4: NX_O15457

Explore proteomics data for MSH4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15457

  • MSH4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MSH4 Protein Expression
    REFSEQ proteins: NP_002431.2  
    ENSEMBL proteins: 
     ENSP00000263187  
    Reactome Protein details: O15457
    Human Recombinant Protein Products for MSH4: 
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    Novus Biologicals MSH4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MSH4 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793condensed chromosome ----
    GO:0000794condensed nuclear chromosome ----
    GO:0000795synaptonemal complex IBA--
    GO:0005634nucleus TAS9299235
    GO:0032300NOT mismatch repair complex IRD--

    MSH4 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for MSH4 

    Assay Products for MSH4: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MSH4 
    Cloud-Clone Corp. CLIAs for MSH4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR007861 DNA_mismatch_repair_MutS_clamp
     IPR007696 DNA_mismatch_repair_MutS_core
     IPR007860 DNA_mmatch_repair_MutS_con_dom
     IPR027417 P-loop_NTPase
     IPR000432 DNA_mismatch_repair_MutS_C

    Graphical View of Domain Structure for InterPro Entry O15457

    ProtoNet protein and cluster: O15457

    UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457
    Similarity: Belongs to the DNA mismatch repair MutS family


    MSH4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSH4_HUMAN, O15457
    Function: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of
    homologous chromosomes at meiosis

         Genatlas biochemistry entry for MSH4:
    yeast meiosis-specific protein (Mut S homolog 4) expressed in testis and ovary,interacting with MSH5,not involved
    in mismatch repair

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9299235
    GO:0003684NOT damaged DNA binding IRD--
    GO:0005515protein binding IPI16397227
    GO:0005524ATP binding IEA--
    GO:0008094DNA-dependent ATPase activity IBA--
         
    MSH4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MSH4:
     Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Msh4):
     behavior/neurological  endocrine/exocrine gland  reproductive system 

    MSH4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Msh4tm1Wed for MSH4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MSH4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MSH4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSH4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSH4 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate MSH4:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidMSH4 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MSH4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Meiotic Synapsis
    Meiosis0.70
    Meiotic Recombination0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for MSH4
        Meiosis
    Meiotic Recombination



    MSH4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MSH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/73 Interacting proteins for MSH4 (O154572, 3 ENSP000002631874) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227314O431962, 3MINT-7158693 MINT-7158702 MINT-7158714 MINT-7158651 I2D: score=9 
    ENSG00000230293O431962, 3MINT-7158693 MINT-7158702 MINT-7158714 MINT-7158651 I2D: score=9 
    ENSG00000235222O431962, 3MINT-7158693 MINT-7158702 MINT-7158714 MINT-7158651 I2D: score=9 
    MSH5O431962, 3, ENSP000003648944MINT-7158693 MINT-7158702 MINT-7158714 MINT-7158651 I2D: score=9 STRING: ENSP00000364894
    CALM1P621583I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000710NOT meiotic mismatch repair IRD--
    GO:0001541ovarian follicle development IEA--
    GO:0006298mismatch repair ----
    GO:0007126meiosis ----
    GO:0007129synapsis ----

    MSH4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSH4

    Search CenterWatch for drugs/clinical trials and news about MSH4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSH4 gene: 
    NM_002440.3  

    Unigene Cluster for MSH4:

    MutS homolog 4 (E. coli)
    Hs.216639  [show with all ESTs]
    Unigene Representative Sequence: NM_002440
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263187(uc001dhd.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSH4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MSH4:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidMSH4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MSH4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSH4
    Clone
    Products:
         
    OriGene clones in human, mouse for MSH4 (see all 6)
    OriGene ORF clones in mouse, rat for MSH4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSH4 (NM_002440)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSH4
    Sirion Biotech Customized lentivirus for stable overexpression of MSH4 
                         Customized lentivirus expression plasmids for stable overexpression of MSH4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MSH4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSH4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSH4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSH4

    Additional mRNA sequence: 

    AF104243.1 AJ844635.1 BC033030.1 U89293.1 

    2 DOTS entries:

    DT.91721028  DT.451554 

    18 AceView cDNA sequences:

    AA300472 NM_002440 BX115943 AF104243 CB858032 U89293 BF980010 BC033030 
    BG037183 BG190519 BI560598 BI460509 BG197567 BG213204 BG194576 BG205338 
    BG216974 AA868028 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSH4 expression in normal human tissues (normalized intensities)      MSH4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTTGAAG
    MSH4 Expression
    About this image


    MSH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primordial Follicle
             oocyte   
     
     Gonad
             Primary Oocyte Primordial Follicle
     
     Testis (Reproductive System)

    See MSH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSH4

    SOURCE GeneReport for Unigene cluster: Hs.216639

    UniProtKB/Swiss-Prot: MSH4_HUMAN, O15457
    Tissue specificity: Testis and ovary specific

        SABiosciences Expression via Pathway-Focused PCR Array including MSH4: 
              DNA Repair in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MSH4 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msh41 , 5 mutS homolog 4 (E. coli)1, 5 84.27(n)1
    89.15(a)1
      3 (78.70 cM)5
    559931  NM_031870.21  NP_114076.11 
     1538571475 
    chicken
    (Gallus gallus)
    Aves MSH41 mutS homolog 4 (E. coli) 78.22(n)
    82.86(a)
      424725  XM_422549.3  XP_422549.3 
    lizard
    (Anolis carolinensis)
    Reptilia MSH46
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343194.1(3378016-3405609)
    zebrafish
    (Danio rerio)
    Actinopterygii msh41 mutS homolog 4 (E. coli) 59.75(n)
    60.76(a)
      559917  XM_683314.4  XP_688406.1 
    worm
    (Caenorhabditis elegans)
    Secernentea him-141 , 3 recombiation protein3
    Protein HIM-141
    31(a)3
    45.97(n)1
    33.15(a)1
      II(7065050-7069898)3
    1741571  NM_063050.41  NP_495451.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSH41 Msh4p 48.51(n)
    33.57(a)
      850545   NP_116652.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MSH41 DNA mismatch repair protein MSH4 47.61(n)
    37.63(a)
      827450  NM_117842.3  NP_193469.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g04860001 hypothetical protein 46.05(n)
    33.02(a)
      9266513  NM_001188272.1  NP_001175201.1 


    ENSEMBL Gene Tree for MSH4 (if available)
    TreeFam Gene Tree for MSH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSH4 gene
    1 SIMAP similar gene for MSH4 using alignment to 2 protein entries:     MSH4_HUMAN (see all proteins):
    DKFZp434C1615

    MSH4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2684 SNPs in MSH4 are shown (see all 2684)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012775921,2
    C--74390408(+) GTTATG/TTTCAA 1 -- us2k10--------
    rs170975431,2
    C,F,H--74390486(+) GTTCTA/GTAGCA 1 -- us2k111Minor allele frequency- G:0.04NA NS EA WA 1346
    rs749665731,2
    C,F--74390632(+) CTGAAT/ATGGTC 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs11466411,2
    C,F--74390908(-) tgctgC/Ggctcc 1 -- us2k16Minor allele frequency- G:0.33NA WA CSA 127
    rs799661891,2
    C,F--74390942(+) CCTCCG/ATCTGC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs115794651,2
    H--74391101(+) cacctC/Tggcct 1 -- us2k10--------
    rs768182451,2
    C,F--74391169(+) TCACTC/TTAGGG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs57453091,2
    C,F,H--74391744(+) CATGTT/GTAATC 1 -- us2k122Minor allele frequency- G:0.10NS NA EA WA CSA 2165
    rs81794981,2
    C,H--74392027(+) CCTTAG/AGTGGG 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs120215341,2
    C,H--74392389(+) TTAGTG/ACGTCG 1 -- ut514Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for MSH4 (76262567 - 76378923 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MSH4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1103396CNV Deletion17803354
    esv2749996CNV Deletion23290073
    esv1918463CNV Deletion18987734
    esv1540402CNV Insertion17803354
    esv1749246CNV Insertion17803354
    esv2475692CNV Insertion19546169
    nsv1466CNV Loss18451855
    esv2575184CNV Loss19546169
    nsv871671CNV Loss21882294
    nsv519329CNV Gain19592680


    Human Gene Mutation Database (HGMD): MSH4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602105    OMIM disorders: --

    9 diseases for MSH4:    About MalaCards
    premature ovarian failure    breast cancer susceptibility    male infertility    conjunctivitis
    azoospermia    infertility    meningioma    ovarian cancer
    breast cancer


    MSH4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MSH4
    Human Genome Epidemiology (HuGE) Navigator: MSH4 (6 documents)

    Export disorders for MSH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSH4 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MSH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene. (PubMed id 9299235)1, 2, 3, 9 Paquis-Flucklinger V.... Desnuelle C. (1997)
    2. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (2010)
    3. Genetic investigation of four meiotic genes in women with premature ovarian failure. (PubMed id 18166824)1, 4 Mandon-Pepin B....Fellous M. (2008)
    4. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. MSH4 acts in conjunction with MLH1 during mammalian meiosis. (PubMed id 10928988)1, 9 Santucci-Darmanin S....Paquis-Flucklinger V. (2000)
    7. Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1. (PubMed id 12591739)1, 9 Her C....Zhou F. (2003)
    8. Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. (PubMed id 9787078)1, 9 Winand N.J.... Kolodner R.D. (1998)
    9. Mutation analysis of three genes in patients with mat uration arrest of spermatogenesis and couples with recurrent miscarriages. (PubMed id 21126912)1 Stouffs K....Lissens W. (2011)
    10. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4438 HGNC: 7327 AceView: MSH4 Ensembl:ENSG00000057468 euGenes: HUgn4438
    ECgene: MSH4 H-InvDB: MSH4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSH4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSH4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/msh4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSH4 gene:
    Search GeneIP for patents involving MSH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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