Aliases for MSH4 Gene
External Ids for MSH4 Gene
Previous GeneCards Identifiers for MSH4 Gene
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
GeneCards Summary for MSH4 Gene
MSH4 (MutS Homolog 4) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis. GO annotations related to this gene include damaged DNA binding and mismatched DNA binding.
UniProtKB/Swiss-Prot for MSH4 Gene
Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.