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MSH3 Gene

protein-coding   GIFtS: 64
GCID: GC05P079986

MutS Homolog 3

(Previous names: mutS (E. coli) homolog 3, mutS homolog 3 (E. coli))
  See MSH3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MutS Homolog 31 2     MutS (E. Coli) Homolog 31
Divergent Upstream Protein1 2 3     MutS Homolog 3 (E. Coli)1
Mismatch Repair Protein 11 2 3     DNA Mismatch Repair Protein Msh32
DUP2 3     DUC13
MRP12 3     DUG3
hMSH32 3     

External Ids:    HGNC: 73261   Entrez Gene: 44372   Ensembl: ENSG000001133187   OMIM: 6008875   UniProtKB: P205853   

Export aliases for MSH3 gene to outside databases

Previous GC identifers: GC05P078772 GC05P080189 GC05P079989 GC05P080034 GC05P075159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSH3 Gene:
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA
mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex
with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The
repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this
gene are a cause of susceptibility to endometrial cancer. (provided by RefSeq, Mar 2011)

GeneCards Summary for MSH3 Gene:
MSH3 (mutS homolog 3) is a protein-coding gene. Diseases associated with MSH3 include endometrial carcinoma, somatic. GO annotations related to this gene include single-stranded DNA binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585
Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form
MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer
bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops
(IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer,
which is thought to be responsible for directing the downstream MMR events, including strand discrimination,
excision, and resynthesis

Gene Wiki entry for MSH3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSH3 gene promoter:
         USF1   Sp1   p53   USF2   USF-1:USF-2   Pax-3   POU2F1   USF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSH3 promoter sequence
   Search Chromatin IP Primers for MSH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11-q12   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q11-q12

MSH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSH3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P079986:  view genomic region     (about GC identifiers)

Start:
79,950,294 bp from pter      End:
80,172,634 bp from pter
Size:
222,341 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585 (See protein sequence)
Recommended Name: DNA mismatch repair protein Msh3  
Size: 1137 amino acids; 127412 Da
Subunit: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).
Interacts with EXO1
Sequence caution: Sequence=AAH11817.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
4 PDB 3D structures from and Proteopedia for MSH3:
3THW (3D)        3THX (3D)        3THY (3D)        3THZ (3D)    
Secondary accessions: A1L482 A6NMM6 Q6PJT5 Q86UQ6 Q92867

Explore the universe of human proteins at neXtProt for MSH3: NX_P20585

Explore proteomics data for MSH3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MSH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002430.3  
    ENSEMBL proteins: 
     ENSP00000265081  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR007861 DNA_mismatch_repair_MutS_clamp
     IPR007696 DNA_mismatch_repair_MutS_core
     IPR007695 DNA_mismatch_repair_MutS-lik_N
     IPR007860 DNA_mmatch_repair_MutS_con_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P20585

    ProtoNet protein and cluster: P20585

    2 Blocks protein domains:
    IPB007695 DNA mismatch repair protein MutS
    IPB007696 MutS III


    UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585
    Similarity: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily


    Find genes that share domains with MSH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MSH3_HUMAN, P20585
    Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form
    MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer
    bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops
    (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer,
    which is thought to be responsible for directing the downstream MMR events, including strand discrimination,
    excision, and resynthesis

         Genatlas biochemistry entry for MSH3:
    yeast mutator gene homolog (bacteria mutS),complexing with MSH2 in mismatch repair,with reduced expression in
    hematological malignancies and in non-small cell lung cancer,overlapping dehydrofolate reductase and transcribed
    in opposite orientation (see TSG5B),deleted in sporadic colorectal cancer in breast cancer

         Gene Ontology (GO): Selected molecular function terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000403Y-form DNA binding IBA--
    GO:0000404loop DNA binding IBA--
    GO:0000406double-strand/single-strand DNA junction binding IBA--
    GO:0003677DNA binding ----
    GO:0003684damaged DNA binding ----
         
    Find genes that share ontologies with MSH3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Msh3):
     cellular  homeostasis/metabolism  integument  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with MSH3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MSH3: Msh3tm1Htr Msh3tm1Rak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MSH3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSH3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSH3

    miRNA
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    miRTarBase miRNAs that target MSH3:
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    Block miRNA regulation of human, mouse, rat MSH3 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate MSH3:
    hsa-miR-3163 hsa-miR-1178 hsa-miR-576-5p hsa-let-7a-2* hsa-miR-944 hsa-miR-664 hsa-let-7g* hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidMSH3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MSH3

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome IBA--
    GO:0005634nucleus IDA--
    GO:0032302MutSbeta complex IDA8942985

    Find genes that share ontologies with MSH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MSH3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Telomere C-strand (Lagging Strand) Synthesis
    Mismatch repair0.56
    Mismatch Repair in Eukaryotes0.54
    2Endometrial cancer
    Colorectal cancer0.42
    3Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32
    4Pathways in cancer
    Pathways in cancer
    5DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage Role of Brca1 and Brca2 in DNA repair


    Find genes that share SuperPaths with MSH3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MSH3
        Mismatch Repair in Eukaryotes
    DNA Repair Mechanisms
    Colorectal Cancer Metastasis

    1 GeneGo (Thomson Reuters) Pathway for MSH3
        DNA damage Role of Brca1 and Brca2 in DNA repair


    3 Kegg Pathways  (Kegg details for MSH3):
        Mismatch repair
    Pathways in cancer
    Colorectal cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MSH3: 
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Liver Cancer in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MSH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MSH3 (P205851, 2, 3 ENSP000002650814) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MSH2P432461, 3, ENSP000002331464EBI-1164205,EBI-355888 I2D: score=10 STRING: ENSP00000233146
    HIST1H2BCP628073I2D: score=2 
    HIST1H2BEP628073I2D: score=2 
    HIST1H2BFP628073I2D: score=2 
    HIST1H2BGP628073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000710meiotic mismatch repair IBA--
    GO:0006200ATP catabolic process IBA--
    GO:0006281DNA repair IDA8942985
    GO:0006298mismatch repair IMP8782829
    GO:0007131reciprocal meiotic recombination IBA--

    Find genes that share ontologies with MSH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSH3

    5 Novoseek inferred chemical compound relationships for MSH3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mononucleotide 74.1 4 10918391 (2), 14871813 (1)
    dihydrofolate 65.6 10 8029024 (2), 1451803 (2), 7971995 (1), 9294177 (1) (see all 5)
    cisplatin 26.1 4 7971995 (2), 9889125 (1)
    doxorubicin 13.1 1 9889125 (1)
    alanine 1.64 1 11005803 (1)



    Find genes that share compounds with MSH3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MSH3 gene: 
    NM_002439.4  

    Unigene Cluster for MSH3:

    MutS homolog 3 (E. coli)
    Hs.280987  [show with all ESTs]
    Unigene Representative Sequence: NM_002439
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265081(uc003kgz.3) ENST00000512531 ENST00000512258
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate MSH3:
    hsa-miR-3163 hsa-miR-1178 hsa-miR-576-5p hsa-let-7a-2* hsa-miR-944 hsa-miR-664 hsa-let-7g* hsa-miR-590-3p
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      QuantiFast Probe-based Assays in human, mouse, rat MSH3

    Additional mRNA sequence: 

    AK289856.1 BC004177.2 BC011817.2 BC017273.2 BC098436.1 BC130434.1 BC130436.1 J04810.1 
    U61981.1 

    4 DOTS entries:

    DT.110960  DT.92455271  DT.95268392  DT.100751042 

    Selected AceView cDNA sequences (see all 36):

    AA251023 BU172337 BC017273 AI888396 AA382889 CB144035 CK000914 BG199292 
    J04810 BX481637 BM999530 BF104775 CA429363 BP374216 BG202122 AW674277 
    BG188772 BV169317 AW069265 AU139133 BI222414 BE514324 AA969963 AW473270 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTAAAA
    MSH3 Expression
    About this image


    MSH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
    MSH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.280987
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MSH3: 
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Liver Cancer in human mouse rat
              DNA Repair in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MSH3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msh31 , 5 mutS homolog 3 (E. coli)1, 5 82.78(n)1
    81.9(a)1
      13 (47.63 cM)5
    176861  NM_010829.21  NP_034959.21 
     922118815 
    chicken
    (Gallus gallus)
    Aves MSH31 mutS homolog 3 (E. coli) 72.21(n)
    69.93(a)
      427318  XM_004949462.1  XP_004949519.1 
    lizard
    (Anolis carolinensis)
    Reptilia MSH36
    mutS homolog 3
    64(a)
    1 ↔ 1
    2(17203742-17274996)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia msh31 mutS homolog 3 (E. coli) 66.5(n)
    64.87(a)
      100486354  XM_002942361.2  XP_002942407.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283622 Transcribed sequence with weak similarity to protein more 75.44(n)    57047801 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSH3(YCR092C)4 Mismatch repair protein, forms dimers with Msh2p that more   --   3(279820-276764) 850454  NP_010016.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MSH31 MSH3 50.18(n)
    43.14(a)
      828659  NM_118686.2  NP_194284.2 
    rice
    (Oryza sativa)
    Liliopsida Os.273602 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.11(n)    AK065300.1 


    ENSEMBL Gene Tree for MSH3 (if available)
    TreeFam Gene Tree for MSH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSH3 gene
    1 SIMAP similar gene for MSH3 using alignment to 2 protein entries:     MSH3_HUMAN (see all proteins):
    DKFZp434C1615

    Find genes that share paralogs with MSH3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSH3 (see all 4788)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61517011,2
    F--75213342(+) tatttT/AtttTT 1 -- int11Minor allele frequency- A:0.04NS 168
    rs623669471,2
    --75228645(+) TTTTAA/TTTTGA 1 -- int10--------
    rs716035631,2
    C--75253257(+) TATTT-/ACACACAC/
    ACACACACACAC
    ACACA
    1 -- int11NA 2
    rs1383050391,2
    C--75254639(+) CCAGA-/GTGT/GTGTGT/GTG
    TGTGT
    /GTGTGTGTGTGT
    GTGTG
    3 -- int1 cds10--------
    rs343811501,2
    C--75255102(+) GTCTA-/TTCAGA 1 -- int10--------
    rs1995252991,2
    C--75286945(-) AACAAA/GGGGAA 1 -- int10--------
    rs341780431,2
    C--75302944(+) GATGAGG/-ACAGA 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs591865781,2
    C--75310168(+) CCCCC-/C/CT/T
            
    TACCT
    1 -- int10--------
    rs2010235761,2
    --75314984(+) AACAA-/TATT  
            
    ACAGT
    1 -- int10--------
    rs676202271,2
    C--75314985(+) ACAAT-/ATTA  
            
    CAGTG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for MSH3 (79950294 - 80172634 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MSH3 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2360560CNV Deletion18987734
    esv4350CNV Deletion18987735
    dgv992e201CNV Deletion23290073
    esv2730371CNV Deletion23290073
    esv1008736CNV Deletion20482838
    esv2730372CNV Deletion23290073
    esv2730379CNV Deletion23290073
    esv2730374CNV Deletion23290073
    esv2730375CNV Deletion23290073
    esv2730377CNV Deletion23290073

    Human Gene Mutation Database (HGMD): MSH3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSH3
    DNA2.0 Custom Variant and Variant Library Synthesis for MSH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600887    OMIM disorders: --

    UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585
  • Endometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus.
    Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other
    fluids. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 1 disease for MSH3:    
    About MalaCards
    endometrial carcinoma, somatic

    2 diseases from the University of Copenhagen DISEASES database for MSH3:
    Lynch syndrome     Colorectal cancer

    Find genes that share disorders with MSH3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MSH3 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microsatellite instability 81.2 7 8782829 (2), 9699180 (1), 7479796 (1), 10069456 (1)
    endometrial cancer 57.4 4 9699180 (3), 8782829 (1)
    colorectal cancer 51 5 14871813 (2), 9740671 (1), 10545954 (1)
    endometrial carcinoma 41.6 4 8782829 (2), 15350299 (1)
    colorectal carcinoma 34.9 2 14871813 (2)
    somatic mutations 30.6 2 9927063 (1), 15350299 (1)
    ovarian cancer 22.1 1 16774946 (1)
    primary tumor 21.8 2 14871813 (1)
    tumors 17.8 26 14871813 (6), 10918391 (2), 9699180 (2), 10751599 (1) (see all 6)
    bladder cancer 17.1 1 15541380 (1)

    Genetic Association Database (GAD): MSH3
    Human Genome Epidemiology (HuGE) Navigator: MSH3 (34 documents)

    Export disorders for MSH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSH3 gene, integrated from 10 sources (see all 133):
    (articles sorted by number of sources associating them with MSH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability. (PubMed id 10944853)1, 2, 4 Orimo H.... Shimada T. (J. Hum. Genet. 2000)
    2. Common variants in mismatch repair genes and risk of invasive ovarian cancer. (PubMed id 16774946)1, 4, 9 Song H....Gayther S.A. (Carcinogenesis 2006)
    3. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. (PubMed id 8942985)1, 2, 9 Acharya S.... Fishel R. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    4. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    10. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4437 HGNC: 7326 AceView: MSH3 Ensembl:ENSG00000113318 euGenes: HUgn4437
    ECgene: MSH3 Kegg: 4437 H-InvDB: MSH3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MSH3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MSH3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/msh3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSH3 gene:
    Search GeneIP for patents involving MSH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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