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Aliases for MSH3 Gene

Aliases for MSH3 Gene

  • MutS Homolog 3 2 3
  • Divergent Upstream Protein 2 3 4
  • Mismatch Repair Protein 1 2 3 4
  • HMSH3 3 4
  • MRP1 3 4
  • DUP 3 4
  • DNA Mismatch Repair Protein Msh3 3
  • MutS (E. Coli) Homolog 3 2
  • MutS Homolog 3 (E. Coli) 2
  • DUC1 4
  • DUG 4

External Ids for MSH3 Gene

Summaries for MSH3 Gene

Entrez Gene Summary for MSH3 Gene

  • The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

GeneCards Summary for MSH3 Gene

MSH3 (MutS Homolog 3) is a Protein Coding gene. Diseases associated with MSH3 include endometrial cancer. Among its related pathways are Pathways in cancer and Chks in Checkpoint Regulation. GO annotations related to this gene include protein homodimerization activity and single-stranded DNA binding.

UniProtKB/Swiss-Prot for MSH3 Gene

  • Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis

Gene Wiki entry for MSH3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSH3 Gene

Genomics for MSH3 Gene

Genomic Location for MSH3 Gene

Start:
80,654,648 bp from pter
End:
80,876,815 bp from pter
Size:
222,168 bases
Orientation:
Plus strand

Genomic View for MSH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSH3 Gene

Regulatory Elements for MSH3 Gene

Proteins for MSH3 Gene

  • Protein details for MSH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20585-MSH3_HUMAN
    Recommended name:
    DNA mismatch repair protein Msh3
    Protein Accession:
    P20585
    Secondary Accessions:
    • A1L480
    • A1L482
    • A6NMM6
    • Q6PJT5
    • Q86UQ6
    • Q92867

    Protein attributes for MSH3 Gene

    Size:
    1137 amino acids
    Molecular mass:
    127412 Da
    Quaternary structure:
    • Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1.
    SequenceCaution:
    • Sequence=AAH11817.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MSH3 Gene

neXtProt entry for MSH3 Gene

Proteomics data for MSH3 Gene at MOPED

Post-translational modifications for MSH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSH3 Gene

Domains for MSH3 Gene

UniProtKB/Swiss-Prot:

MSH3_HUMAN
Family:
  • Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.:
    • P20585
genes like me logo Genes that share domains with MSH3: view

No data available for Gene Families for MSH3 Gene

Function for MSH3 Gene

Molecular function for MSH3 Gene

GENATLAS Biochemistry: yeast mutator gene homolog (bacteria mutS),complexing with MSH2 in mismatch repair,with reduced expression in hematological malignancies and in non-small cell lung cancer,overlapping dehydrofolate reductase and transcribed in opposite orientation (see TSG5B),deleted in sporadic colorectal cancer in breast cancer
UniProtKB/Swiss-Prot Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis

Gene Ontology (GO) - Molecular Function for MSH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000403 Y-form DNA binding IBA --
GO:0000404 heteroduplex DNA loop binding IBA --
GO:0000406 double-strand/single-strand DNA junction binding IBA --
GO:0003677 DNA binding --
GO:0003684 damaged DNA binding --
genes like me logo Genes that share ontologies with MSH3: view
genes like me logo Genes that share phenotypes with MSH3: view

Animal Models for MSH3 Gene

MGI Knock Outs for MSH3:

miRNA for MSH3 Gene

miRTarBase miRNAs that target MSH3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MSH3 Gene

Localization for MSH3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSH3 Gene COMPARTMENTS Subcellular localization image for MSH3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MSH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IBA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0032302 MutSbeta complex IDA 8942985
genes like me logo Genes that share ontologies with MSH3: view

Pathways for MSH3 Gene

genes like me logo Genes that share pathways with MSH3: view

Pathways by source for MSH3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for MSH3 Gene
3 KEGG pathways for MSH3 Gene

Gene Ontology (GO) - Biological Process for MSH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000710 meiotic mismatch repair IBA --
GO:0006200 obsolete ATP catabolic process --
GO:0006281 DNA repair TAS --
GO:0006298 mismatch repair TAS --
GO:0007131 reciprocal meiotic recombination IBA --
genes like me logo Genes that share ontologies with MSH3: view

Compounds for MSH3 Gene

(5) Novoseek inferred chemical compound relationships for MSH3 Gene

Compound -log(P) Hits PubMed IDs
mononucleotide 74.1 3
dihydrofolate 65.6 7
cisplatin 26.1 3
doxorubicin 13.1 1
alanine 1.64 1
genes like me logo Genes that share compounds with MSH3: view

Transcripts for MSH3 Gene

mRNA/cDNA for MSH3 Gene

Unigene Clusters for MSH3 Gene

MutS homolog 3 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MSH3 Gene

No ASD Table

Relevant External Links for MSH3 Gene

GeneLoc Exon Structure for
MSH3
ECgene alternative splicing isoforms for
MSH3

Expression for MSH3 Gene

mRNA expression in normal human tissues for MSH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MSH3 Gene

SOURCE GeneReport for Unigene cluster for MSH3 Gene Hs.280987

genes like me logo Genes that share expressions with MSH3: view

Orthologs for MSH3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MSH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSH3 36
  • 98.91 (n)
  • 98.28 (a)
MSH3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSH3 36
  • 88.6 (n)
  • 86.08 (a)
MSH3 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSH3 36
  • 90.36 (n)
  • 88.11 (a)
MSH3 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msh3 36
  • 82.78 (n)
  • 81.9 (a)
Msh3 16
Msh3 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSH3 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Msh3 36
  • 82.62 (n)
  • 81.94 (a)
chicken
(Gallus gallus)
Aves MSH3 36
  • 72.21 (n)
  • 69.93 (a)
MSH3 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSH3 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia msh3 36
  • 66.5 (n)
  • 64.87 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28362 36
msh3 36
  • 61.69 (n)
  • 60.31 (a)
msh3 37
  • 52 (a)
OneToMany
msh3 37
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSH3 37
  • 31 (a)
OneToOne
MSH3 39
thale cress
(Arabidopsis thaliana)
eudicotyledons MSH3 36
  • 50.18 (n)
  • 43.14 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1594 36
rice
(Oryza sativa)
Liliopsida Os.27360 36
Os04g0682900 36
  • 46.26 (n)
  • 36.87 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08115 36
  • 47.35 (n)
  • 42.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes msh3 36
  • 49.53 (n)
  • 40.16 (a)
Species with no ortholog for MSH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSH3 Gene

ENSEMBL:
Gene Tree for MSH3 (if available)
TreeFam:
Gene Tree for MSH3 (if available)

Paralogs for MSH3 Gene

Selected SIMAP similar genes for MSH3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MSH3: view

No data available for Paralogs for MSH3 Gene

Variants for MSH3 Gene

Sequence variations from dbSNP and Humsavar for MSH3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26266 -- 80,744,875(-) TCAAA(A/G)CCCTC intron-variant
rs26267 -- 80,744,855(+) GAGGA(G/T)AGATG intron-variant
rs26268 -- 80,740,650(+) ccact(A/G)tgcct intron-variant
rs26278 -- 80,826,303(+) TGTAA(A/G)TCACT intron-variant
rs26279 - 80,873,118(+) CAGGC(A/G)CAGCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MSH3 Gene

Variant ID Type Subtype PubMed ID
nsv483112 CNV Loss 15286789
nsv10710 CNV Gain 18304495
nsv823107 CNV Gain 20364138
esv2730370 CNV Deletion 23290073
esv2673567 CNV Deletion 23128226
nsv882231 CNV Loss 21882294
esv2730371 CNV Deletion 23290073
esv2730372 CNV Deletion 23290073
esv1765430 CNV Insertion 17803354
esv2730374 CNV Deletion 23290073
esv2730375 CNV Deletion 23290073
dgv992e201 CNV Deletion 23290073
esv2730377 CNV Deletion 23290073
nsv10711 CNV Gain 18304495
esv2452635 CNV Deletion 19546169
esv2360560 CNV Deletion 18987734
esv4350 CNV Deletion 18987735
esv2730379 CNV Deletion 23290073
esv1008736 CNV Deletion 20482838
esv1113629 CNV Deletion 17803354
nsv329246 CNV Loss 16902084
esv7059 CNV Loss 19470904
dgv1025e199 CNV Deletion 23128226
esv267537 CNV Insertion 20981092

Relevant External Links for MSH3 Gene

HapMap Linkage Disequilibrium report
MSH3
Human Gene Mutation Database (HGMD)
MSH3

Disorders for MSH3 Gene

UniProtKB/Swiss-Prot

MSH3_HUMAN
  • Endometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) MalaCards Diseases for MSH3 Gene

Search for MSH3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MSH3 Gene

(12) Novoseek inferred disease relationships for MSH3 Gene

Disease -log(P) Hits PubMed IDs
microsatellite instability 81.2 5
endometrial cancer 57.4 4
colorectal cancer 51 4
endometrial carcinoma 41.6 3
colorectal carcinoma 34.9 2

Relevant External Links for MSH3

Genetic Association Database (GAD)
MSH3
Human Genome Epidemiology (HuGE) Navigator
MSH3
genes like me logo Genes that share disorders with MSH3: view

Publications for MSH3 Gene

  1. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. (PMID: 8942985) Acharya S. … Fishel R. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  2. Common variants in mismatch repair genes and risk of invasive ovarian cancer. (PMID: 16774946) Song H. … Gayther S.A. (Carcinogenesis 2006) 3 23 49
  3. Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability. (PMID: 10944853) Orimo H. … Shimada T. (J. Hum. Genet. 2000) 3 4 49
  4. Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. (PMID: 18922920) Haugen A.C. … Koi M. (Cancer Res. 2008) 3 23
  5. Nine-bp repeat polymorphism in exon 1 of the hMSH3 gene. (PMID: 8851770) Nakajima E. … Shimada T. (Jpn. J. Hum. Genet. 1995) 3 4

Products for MSH3 Gene

Sources for MSH3 Gene

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