MSH3 Gene
protein-coding GIFtS: 65
GCID: GC05P079986
|
|
mutS homolog 3 (E. coli)(Previous name: mutS (E. coli) homolog 3 )
| |
Aliases
for MSH3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MutS Homolog 3 (E. Coli)1 2 | | HMSH31 | | DUP1 2 3 | | MutS (E. Coli) Homolog 31 | | MRP11 2 3 | | DNA Mismatch Repair Protein Msh32 | | Divergent Upstream Protein2 3 | | DUC13 | | Mismatch Repair Protein 12 3 | | DUG3 |
Export aliases for MSH3 gene to outside databasesPrevious GC identifers: GC05P078772 GC05P080189 GC05P079989 GC05P080034 GC05P075159 |
Summaries
for MSH3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MSH3:
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNAmismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex withMutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat ispresent 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a causeof susceptibility to endometrial cancer. (provided by RefSeq, Mar 2011)
UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutSbeta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNAhelix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought tobe responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis
Gene Wiki entry for MSH3
|
Genomic Views
for MSH3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MSH3 gene promoter:
USF1 Sp1 p53 USF2 USF-1:USF-2 Pax-3 POU2F1 USF-1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MSH3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSH3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q11-q12 Ensembl cytogenetic band: 5q14.1 HGNC cytogenetic band: 5q11-q12MSH3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P079986: view genomic region
(about GC identifiers)
Start:
|
79,950,294 bp from pter |
End:
|
80,172,634 bp from pter |
Size:
|
222,341 bases |
Orientation:
|
plus strand |
|
Proteins
for MSH3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585 (See
protein sequence)Recommended Name: DNA mismatch repair protein Msh3 Size: 1137 amino acids; 127412 Da
Subunit: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).Interacts with EXO1
Sequence caution: Sequence=AAH11817.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
4 PDB 3D structures from  and Proteopedia  for MSH3:3THW (3D)
3THX (3D)
3THY (3D)
3THZ (3D)
Secondary accessions: A1L482 A6NMM6 Q6PJT5 Q86UQ6 Q92867Explore the universe of human proteins at neXtProt for MSH3: NX_P20585
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P20585
MSH3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002430.3
ENSEMBL proteins: ENSP00000265081
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MSH3 for ontologies About GeneDecksing
MSH3 Antibody Products:
Assay Products for MSH3: |
Protein
Domains /
Families
for MSH3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MSH3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P20585ProtoNet protein and cluster: P20585 2 Blocks protein families: IPB007695 DNA mismatch repair protein MutS IPB007696 MutS III
UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585Similarity: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily |
Function
for MSH3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585Function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutSbeta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNAhelix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought tobe responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis Genatlas biochemistry entry for MSH3:yeast mutator gene homolog (bacteria mutS),complexing with MSH2 in mismatch repair,with reduced expression inhematological malignancies and in non-small cell lung cancer,overlapping dehydrofolate reductase and transcribed inopposite orientation (see TSG5B),deleted in sporadic colorectal cancer in breast cancer
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSH3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: MSH3 (NM_002439) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MSH3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSH3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH3 |
Gene Ontology (GO): 5/18 molecular function terms (GO ID links to tree view) (see all 18): About this table
MSH3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for MSH3: Msh3tm1Htr Msh3tm1Rak
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Msh3):
MSH3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MSH3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lagging Strand Synthesis | | | 2 | Formation of RNA Pol II elongation complex | | | 3 | Colorectal Cancer Metastasis | | | 4 | Pathways in cancer | | | 5 | Endometrial cancer | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MSH3
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MSH3
1  GeneGo (Thomson Reuters) Pathway for MSH3
3 
Kegg Pathways (Kegg details for MSH3):
MSH3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MSH3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/90 Interacting proteins for MSH3 (P205851, 2, 3 ENSP000002650814) via UniProtKB, MINT, STRING, and/or I2D (see all 90)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
MSH3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MSH3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MSH3 for compounds About GeneDecksing
 Browse Tocris compounds for MSH3
5 Novoseek chemical compound relationships for MSH3 gene About this table
Search CenterWatch for drugs/clinical trials and news about MSH3
|
Transcripts
for MSH3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MSH3 gene: NM_002439.4 Unigene Cluster for MSH3: MutS homolog 3 (E. coli) Hs.280987 [show with all ESTs]Unigene Representative Sequence: NM_0024393 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265081(uc003kgz.3) ENST00000512531 ENST00000512258
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSH3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSH3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MSH3 (NM_002439) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MSH3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSH3 |
Additional cDNA sequence: AK289856.1 BC004177.2 BC011817.2 BC017273.2 BC098436.1 BC130434.1 BC130436.1 J04810.1 U61981.1 4 DOTS entries: DT.110960 DT.92455271 DT.95268392 DT.100751042 24/36 AceView cDNA sequences (see all 36): CB144035 AA251023 AA382889 BU172337 AI888396 BC017273 AW069265 BM999530 BG188772 BF104775 BP374216 BG199292 BG202122 J04810 AW674277 AU139133 CA429363 CK000914 BX481637 BV169317 BV175078 BU430026 BI222414 AW473270
GeneLoc Exon Structure
|
Expression
for MSH3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MSH3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTTAAAA
About this image
See MSH3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MSH3
SOURCE GeneReport for Unigene cluster: Hs.280987
SABiosciences Expression via Pathway-Focused PCR Arrays including MSH3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSH3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSH3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH3 |
Orthologs
for MSH3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MSH3 gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Msh31 , 5 |
mutS homolog 3 (E. coli)1, 5 |
82.48(n)1
81.63(a)1 |
|
13 (47.63 cM)5
176861 NM_010829.21 NP_034959.21
922118815 |
chicken
(Gallus gallus) |
Aves |
MSH31 |
mutS homolog 3 (E. coli) |
72.24(n)
70.12(a) |
|
427318 XM_003643079.1 XP_003643127.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MSH36 |
-- |
67(a) |
1 ↔ 1 |
2(17211752-17272810) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.283622 |
Transcribed sequence with weak similarity to protein more |
75.44(n) |
|
57047801 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MSH31 |
DNA mismatch repair protein Msh3 |
50.14(n)
43.14(a) |
|
828659 NM_118686.2 NP_194284.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.273602 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.11(n) |
|
AK065300.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
mutS6 |
methyl-directed mismatch repair protein |
25(a) |
possible ortholog |
Chromosome(2855115-2857676) |
ENSEMBL Gene Tree for MSH3 (if available)
TreeFam Gene Tree for MSH3 (if available) |
Paralogs
for MSH3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MSH3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MSH3 (79950294 - 80172634 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for MSH3
8 CNVs: 31243 93111 93112 93114 80963 93113 0065 99183
7 Indels: 12708 42490 46927 40773 28012 62393 33408
Human Gene Mutation Database (HGMD): MSH3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSH3 |
|
Disorders
/ Diseases
for MSH3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MSH3 for disorders About GeneDecksing
OMIM gene information: 600887
OMIM disorders: --
UniProtKB/Swiss-Prot: MSH3_HUMAN, P20585
Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089]
20/34  diseases for MSH3 (see all 34): About MalaCardsendometrial cancer spina bifida adenoid cystic carcinoma lynch syndrome
papillary thyroid carcinoma acute lymphoblastic leukemia basal cell carcinoma lymphoblastic leukemia
acute myeloid leukemia epithelial ovarian cancer werner syndrome myeloid leukemia
mucoepidermoid carcinoma adenoiditis endometrial carcinoma ovarian cancer
colorectal cancer thyroid carcinoma carcinoma leukemia
2 diseases from the University of Copenhagen DISEASES database for MSH3:Lynch syndrome Colorectal cancer 10/12 Novoseek disease relationships for MSH3 gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| microsatellite instability |
81.2 |
7 |
8782829 (2), 9699180 (1), 7479796 (1), 10069456 (1) |
| endometrial cancer |
57.4 |
4 |
9699180 (3), 8782829 (1) |
| colorectal cancer |
51 |
5 |
14871813 (2), 9740671 (1), 10545954 (1) |
| endometrial carcinoma |
41.6 |
4 |
8782829 (2), 15350299 (1) |
| colorectal carcinoma |
34.9 |
2 |
14871813 (2) |
| somatic mutations |
30.6 |
2 |
9927063 (1), 15350299 (1) |
| ovarian cancer |
22.1 |
1 |
16774946 (1) |
| primary tumor |
21.8 |
2 |
14871813 (1) |
| tumors |
17.8 |
26 |
14871813 (6), 10918391 (2), 9699180 (2), 10751599 (1) (see all 6) |
| bladder cancer |
17.1 |
1 |
15541380 (1) |
Genetic Association Database (GAD): MSH3
Human Genome Epidemiology (HuGE) Navigator: MSH3 (34 documents)
Export disorders for MSH3 gene to outside databases
|
Publications
for MSH3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MSH3 gene, integrated from 9 sources (see all 126):
(articles sorted by number of sources associating them with MSH3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability. (PubMed id 10944853)1, 2, 4 Orimo H.... Shimada T. (2000)
- hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. (PubMed id 8942985)1, 2, 9 Acharya S.... Fishel R. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Role of DNA mismatch repair genetic polymorphisms in the risk of childhood acute lymphoblastic leukaemia. (PubMed id 14510941)1, 4 Mathonnet G....Sinnett D. (2003)
- Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes. (PubMed id 14625810)1, 4 Mathonnet G....Sinnett D. (2003)
- Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia. (PubMed id 11895912)1, 4 Krajinovic M....Sinnett D. (2002)
- The interaction of DNA mismatch repair proteins with human exonuclease I. (PubMed id 11427529)1, 2 Schmutte C.... Fishel R. (2001)
- Nine-bp repeat polymorphism in exon 1 of the hMSH3 gene. (PubMed id 8851770)1, 2 Nakajima E.... Shimada T. (1995)
- Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene. (PubMed id 2722860)1, 2 Fujii H. and Shimada T. (1989)
- Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression. (PubMed id 14871813)1, 9 Plaschke J....Schackert H.K. (2004)
|
External Searches for MSH3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MSH3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MSH3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MSH3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MSH3 gene:
Search GeneIP for patents involving MSH3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MSH3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | OriGene Antibodies for MSH3 | | OriGene shRNA RFP for MSH3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSH3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MSH3 | | | OriGene Protein Over-expression Lysate for MSH3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MSH3 | | OriGene 3'-UTR Clone for MSH3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSH3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSH3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MSH3 | | OriGene Custom Protein Services for MSH3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MSH3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSH3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSH3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSH3 |
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| | | | Search Tocris compounds for MSH3 |
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 | | | MSH3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSH3 |
|  |  |  | | | | ThermoFisher Antibodies for MSH3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSH3 |
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