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Aliases for MSGN1 Gene

Aliases for MSGN1 Gene

  • Mesogenin 1 2 3
  • Paraxial Mesoderm-Specific Mesogenin1 3 4
  • Paraxial Mesogenin 2 3
  • PMesogenin1 3 4
  • PMsgn1 3 4
  • Mesogenin-1 3
  • MSOG 3

External Ids for MSGN1 Gene

Previous GeneCards Identifiers for MSGN1 Gene

  • GC02P017923
  • GC02P017997

Summaries for MSGN1 Gene

GeneCards Summary for MSGN1 Gene

MSGN1 (Mesogenin 1) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is MESP1.

UniProtKB/Swiss-Prot for MSGN1 Gene

  • Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MSGN1 Gene

Genomics for MSGN1 Gene

Regulatory Elements for MSGN1 Gene

Genomic Location for MSGN1 Gene

Start:
17,816,496 bp from pter
End:
17,817,101 bp from pter
Size:
606 bases
Orientation:
Plus strand

Genomic View for MSGN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MSGN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MSGN1 Gene

Proteins for MSGN1 Gene

  • Protein details for MSGN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI15-MSGN1_HUMAN
    Recommended name:
    Mesogenin-1
    Protein Accession:
    A6NI15
    Secondary Accessions:

    Protein attributes for MSGN1 Gene

    Size:
    193 amino acids
    Molecular mass:
    20778 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MSGN1 Gene

Proteomics data for MSGN1 Gene at MOPED

Post-translational modifications for MSGN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MSGN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MSGN1 Gene

Domains for MSGN1 Gene

Protein Domains for MSGN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MSGN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NI15

UniProtKB/Swiss-Prot:

MSGN1_HUMAN :
  • A6NI15
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MSGN1: view

No data available for Gene Families for MSGN1 Gene

Function for MSGN1 Gene

Molecular function for MSGN1 Gene

UniProtKB/Swiss-Prot Function: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for MSGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MSGN1: view
genes like me logo Genes that share phenotypes with MSGN1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MSGN1 Gene

Localization for MSGN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MSGN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MSGN1 Gene COMPARTMENTS Subcellular localization image for MSGN1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for MSGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MSGN1: view

Pathways for MSGN1 Gene

SuperPathways for MSGN1 Gene

No Data Available

Interacting Proteins for MSGN1 Gene

Gene Ontology (GO) - Biological Process for MSGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007379 segment specification IEA --
GO:0030154 cell differentiation IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with MSGN1: view

No data available for Pathways by source for MSGN1 Gene

Transcripts for MSGN1 Gene

mRNA/cDNA for MSGN1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MSGN1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MSGN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MSGN1 Gene

No ASD Table

Relevant External Links for MSGN1 Gene

GeneLoc Exon Structure for
MSGN1
ECgene alternative splicing isoforms for
MSGN1

Expression for MSGN1 Gene

mRNA expression in normal human tissues for MSGN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MSGN1 Gene

This gene is overexpressed in Esophagus - Mucosa (19.7), Minor Salivary Gland (9.5), Testis (7.6), and Vagina (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MSGN1 Gene

SOURCE GeneReport for Unigene cluster for MSGN1 Gene Hs.705359

genes like me logo Genes that share expressions with MSGN1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MSGN1 Gene

Orthologs for MSGN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MSGN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MSGN1 35
  • 98.96 (n)
  • 98.96 (a)
MSGN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MSGN1 35
  • 85.84 (n)
  • 87.56 (a)
MSGN1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MSGN1 35
  • 80.32 (n)
  • 80.85 (a)
MSGN1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Msgn1 35
  • 80.93 (n)
  • 79.68 (a)
Msgn1 16
Msgn1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MSGN1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MSGN1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Msgn1 35
  • 81.28 (n)
  • 79.14 (a)
chicken
(Gallus gallus)
Aves MSGN1 35
  • 68.29 (n)
  • 69.51 (a)
MSGN1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MSGN1 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.483 35
tropical clawed frog
(Silurana tropicalis)
Amphibia msgn1 35
  • 59.19 (n)
  • 56.41 (a)
Str.10200 35
zebrafish
(Danio rerio)
Actinopterygii msgn1 35
  • 62.96 (n)
  • 60.68 (a)
msgn1 36
  • 50 (a)
OneToOne
Species with no ortholog for MSGN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MSGN1 Gene

ENSEMBL:
Gene Tree for MSGN1 (if available)
TreeFam:
Gene Tree for MSGN1 (if available)

Paralogs for MSGN1 Gene

Paralogs for MSGN1 Gene

genes like me logo Genes that share paralogs with MSGN1: view

Variants for MSGN1 Gene

Sequence variations from dbSNP and Humsavar for MSGN1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1471343 -- 17,816,077(+) GGTGG(A/C)GGGGA upstream-variant-2KB
rs1471344 -- 17,816,314(+) CTAAT(C/T)ATCAA upstream-variant-2KB
rs13001625 -- 17,817,064(+) CTCCT(C/T)AACCG synonymous-codon, reference
rs17315876 -- 17,815,975(+) GACAC(A/G)TTAGG upstream-variant-2KB
rs34069439 - 17,816,758(+) AGCGA(A/T)GGCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MSGN1 Gene

Variant ID Type Subtype PubMed ID
dgv4062n71 CNV Gain 21882294

Relevant External Links for MSGN1 Gene

HapMap Linkage Disequilibrium report
MSGN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MSGN1 Gene

Disorders for MSGN1 Gene

Relevant External Links for MSGN1

Genetic Association Database (GAD)
MSGN1
genes like me logo Genes that share disorders with MSGN1: view

No data available for UniProtKB/Swiss-Prot for MSGN1 Gene

Publications for MSGN1 Gene

  1. The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. (PMID: 10837126) Yoon J.K. … Wold B. (Dev. Biol. 2000) 2 3
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  3. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 48
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for MSGN1 Gene

Sources for MSGN1 Gene

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