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MSC Gene

protein-coding   GIFtS: 58
GCID: GC08M072803

Musculin

(Previous name: musculin (activated B-cell factor-1))
  See MSC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
musculin1 2     Musculin (Activated B-Cell Factor-1)1
Activated B-Cell Factor-11 2     MYOR2
Class A Basic Helix-Loop-Helix Protein 222 3     Activated B-Cell Factor 1, Homolog Of Mouse Musculin2
ABF-12 3     BHLHA223
ABF12 3     Activated B-Cell Factor 13
bHLHa222 3     

External Ids:    HGNC: 73211   Entrez Gene: 92422   Ensembl: ENSG000001788607   OMIM: 6036285   UniProtKB: O606823   

Export aliases for MSC gene to outside databases

Previous GC identifers: GC08M071836 GC08M072694 GC08M072476 GC08M072916 GC08M068248


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MSC Gene:
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a
homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in
vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian
cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MSC Gene:
MSC (musculin) is a protein-coding gene. Diseases associated with MSC include follicular lymphoma. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TCF24.

UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
Function: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a
role in regulating antigen-dependent B-cell differentiation

Gene Wiki entry for MSC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MSC gene promoter:
         HFH-3   AP-1   ATF-2   MyoD   IRF-1   C/EBPalpha   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSC promoter sequence
   Search Chromatin IP Primers for MSC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q13.3

MSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSC gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M072803:  view genomic region     (about GC identifiers)

Start:
72,753,777 bp from pter      End:
72,756,731 bp from pter
Size:
2,955 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682 (See protein sequence)
Recommended Name: Musculin  
Size: 206 amino acids; 22068 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a
heterodimer. Forms a heterodimer with TCF3
Sequence caution: Sequence=AAC15071.1; Type=Frameshift; Positions=189;
Secondary accessions: O75946 Q53XZ2 Q9BRE7

Explore the universe of human proteins at neXtProt for MSC: NX_O60682

Explore proteomics data for MSC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MSC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005089.2  
    ENSEMBL proteins: 
     ENSP00000321445  

    MSC Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MSC

     
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    antibodies-online proteins for MSC (8 products) 

     
    antibodies-online peptides for MSC

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    antibodies-online antibodies for MSC (36 products) 

    MSC Assay Products:

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    Cloud-Clone Corp. ELISAs for MSC
    Cloud-Clone Corp. CLIAs for MSC
    Search eBioscience for ELISAs for MSC 
    antibodies-online kits for MSC (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry O60682

    ProtoNet protein and cluster: O60682

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with MSC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUSC_HUMAN, O60682
    Function: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a
    role in regulating antigen-dependent B-cell differentiation

         Genatlas biochemistry entry for MSC:
    activated B cell factor 1,musculin,mouse homolog,predominantly expressed in a subset of lymphoid tissues in adult
    and activated B cells,maybe involved in regulating antigen-dependent B cell differentiation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9584154
    GO:0003714transcription corepressor activity TAS9584154
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with MSC           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Msc):
     craniofacial  digestive/alimentary  mortality/aging  muscle  normal 

    Find genes that share phenotypes with MSC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Msctm1Eno for MSC

       genOway: Develop your customized and physiologically relevant rodent model for MSC

    miRNA
    Products:
        
    miRTarBase miRNAs that target MSC:
    hsa-mir-378a-3p (MIRT006681), hsa-mir-146a-5p (MIRT045694)

    Block miRNA regulation of human, mouse, rat MSC using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MSC:
    hsa-miR-132* hsa-miR-149 hsa-miR-513a-3p hsa-miR-3605-3p hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidMSC 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSC

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MUSC_HUMAN, O60682: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MSC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MSC About    
    See pathways by source

    SuperPathContained pathways About
    1Id Signaling Pathway
    Id Signaling Pathway


    1 BioSystems Pathway for MSC
        Id Signaling Pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including MSC: 
              Notch Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MSC

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MSC (O606822, 3 ENSP000003214454) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF12Q990813, ENSP000003310574I2D: score=1 STRING: ENSP00000331057
    ID2Q023633, ENSP000002340914I2D: score=2 STRING: ENSP00000234091
    TCF3P159233, ENSP000002629654I2D: score=2 STRING: ENSP00000262965
    TCF4P158843, ENSP000003464404I2D: score=2 STRING: ENSP00000346440
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS9584154
    GO:0014707branchiomeric skeletal muscle development IEA--
    GO:0060021palate development IEA--
    GO:0060539diaphragm development IEA--

    Find genes that share ontologies with MSC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSC (MUSC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MSC gene: 
    NM_005098.3  

    Unigene Cluster for MSC:

    Musculin
    Hs.442619  [show with all ESTs]
    Unigene Representative Sequence: NM_005098
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325509(uc003xyx.1) ENST00000518440 ENST00000521739
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate MSC:
    hsa-miR-132* hsa-miR-149 hsa-miR-513a-3p hsa-miR-3605-3p hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidMSC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MSC
    Clone
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    OriGene clones in human, mouse for MSC (see all 6)
    OriGene ORF clones in mouse, rat for MSC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSC (NM_005098)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSC
    Primer
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    OriGene qPCR primer pairs and template standards for MSC
    OriGene qSTAR qPCR primer pairs in human, mouse for MSC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MSC
      QuantiTect SYBR Green Assays in human, mouse, rat MSC
      QuantiFast Probe-based Assays in human, mouse, rat MSC

    Additional mRNA sequence: 

    AF060154.1 AF087036.1 AK313102.1 BC006313.2 BC067827.1 BT007169.1 

    7 DOTS entries:

    DT.441856  DT.102831245  DT.202475  DT.92427684  DT.92427683  DT.100682158  DT.92427679 

    Selected AceView cDNA sequences (see all 132):

    CR622554 CD367304 BC067827 CR593021 AI298650 CA443950 CD366733 AI819367 
    AI380115 BC006313 BM725166 CB217106 AI583179 BX115600 AI651393 AW241565 
    CR594663 BP374600 AF060154 AI814410 AW136692 CA423951 BX463602 BX355716 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCATTCGTG
    MSC Expression
    About this image


    MSC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 13 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 4 entries
             Paraxial Mesoderm Cells Head Mesenchyme
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Paraxial Mesoderm Cells Head Mesenchyme
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    MSC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442619

    UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
    Tissue specificity: Expressed in lymphoid tissues, B-cell lines and activated B-cells

        Pathway & Disease-focused RT2 Profiler PCR Array including MSC: 
              Notch Signaling Targets in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MSC gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msc1 , 5 musculin1, 5 83.75(n)1
    84.58(a)1
      1 (4.50 cM)5
    176811  NM_010827.21  NP_034957.11 
     147533465 
    chicken
    (Gallus gallus)
    Aves MSC1 musculin 76.95(n)
    77.71(a)
      420179  XM_418293.4  XP_418293.4 
    lizard
    (Anolis carolinensis)
    Reptilia MSC6
    musculin
    46(a)
    1 ↔ 1
    4(32939876-32946819)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia msc1 musculin 67.42(n)
    71.02(a)
      100124790  NM_001102765.1  NP_001096235.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5563961 musculin-like 71.21(n)
    78.18(a)
      556396  XM_679187.6  XP_684279.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta HLH54F6
    HLH54F
    20(a)
    1 → many
    2R(13644922-13648022)


    ENSEMBL Gene Tree for MSC (if available)
    TreeFam Gene Tree for MSC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MSC gene
    TCF242  TCF232  TCF212  
    1 SIMAP similar gene for MSC using alignment to 1 protein entry:     MUSC_HUMAN:
    TCF21

    Find genes that share paralogs with MSC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for MSC    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844994141,2
    --72753305(+) GAAAAG/TCACCG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MSC (72753777 - 72756731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MSC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737154CNV Deletion23290073
    esv33409CNV Loss17666407
    nsv831353CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MSC
    DNA2.0 Custom Variant and Variant Library Synthesis for MSC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603628    OMIM disorders: --

    1 disease for MSC:    
    About MalaCards
    follicular lymphoma

    1 disease from the University of Copenhagen DISEASES database for MSC:
    Hodgkin's lymphoma

    Find genes that share disorders with MSC           About GenesLikeMe

    Genetic Association Database (GAD): MSC
    Human Genome Epidemiology (HuGE) Navigator: MSC (58 documents)

    Export disorders for MSC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSC gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with MSC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. (PubMed id 9584154)1, 2, 3, 9 Massari M.E.... Murre C. (Mol. Cell. Biol. 1998)
    2. Musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle. (PubMed id 9767165)1, 2, 9 Robb L.... Begley C.G. (Mech. Dev. 1998)
    3. Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1. (PubMed id 10198176)1, 3, 9 Robb L....Harvey R.P. (Genomics 1999)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1. (PubMed id 15052269)1, 9 Knight J.C....Kwiatkowski D.P. (Nat. Genet. 2004)
    7. ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma. (PubMed id 18368067)1 Ushmorov A....Wirth T. (Leukemia 2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9242 HGNC: 7321 AceView: MSC Ensembl:ENSG00000178860 euGenes: HUgn9242
    ECgene: MSC H-InvDB: MSC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSC gene:
    Search GeneIP for patents involving MSC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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