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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSC Gene

protein-coding   GIFtS: 56
GCID: GC08M072803

musculin

(Previous name: musculin (activated B-cell factor-1) )
 Explore 8 diseases affiliated with
MSC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MSC    

Aliases
for MSC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Musculin1     MYOR2
ABF-11 2 3     Activated B-Cell Factor 1, Homolog Of Mouse Musculin2
BHLHa221     Activated B-Cell Factor-12
Class A Basic Helix-Loop-Helix Protein 222 3     BHLHA223
ABF12 3     Activated B-Cell Factor 13
Musculin (Activated B-Cell Factor-1)1     

External Ids:    HGNC: 73211   Entrez Gene: 92422   Ensembl: ENSG000001788607   OMIM: 6036285   UniProtKB: O606823   

Export aliases for MSC gene to outside databases

Previous GC identifers: GC08M071836 GC08M072694 GC08M072476 GC08M072916 GC08M068248


Summaries
for MSC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MSC:
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a
homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in
vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells.
This gene is a downstream target of the B-cell receptor signal transduction pathway. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
Function: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in
regulating antigen-dependent B-cell differentiation

Gene Wiki entry for MSC


Genomic Views
for MSC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSC gene promoter:
         HFH-3   AP-1   ATF-2   MyoD   IRF-1   C/EBPalpha   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MSC promoter sequence
   Search SABiosciences Chromatin IP Primers for MSC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q21

MSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSC gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M072803:  view genomic region     (about GC identifiers)

Start:
 72,753,777 bp from pter      End:
 72,756,731 bp from pter
Size:
 2,955 bases      Orientation:
 minus strand

Proteins
for MSC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682 (See protein sequence)
Recommended Name: Musculin  
Size: 206 amino acids; 22068 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a
heterodimer. Forms a heterodimer with TCF3
Subcellular location: Nucleus
Sequence caution: Sequence=AAC15071.1; Type=Frameshift; Positions=189;
Secondary accessions: O75946 Q53XZ2 Q9BRE7

Explore the universe of human proteins at neXtProt for MSC: NX_O60682

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60682

    • MSC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005089.2  
    ENSEMBL proteins: 
     ENSP00000321445  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: MSC
    OriGene Protein Over-expression Lysate: MSC
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    Novus Biologicals MSC Proteins
    Novus Biologicals MSC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MSC

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    MSC for ontologies           About GeneDecksing



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    Uscn Antibodies for MSC
    ThermoFisher Antibodies for MSC

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    Uscn ELISAs and CLIAs for MSC

    Protein Domains /
    Families
    for MSC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MSC for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry O60682

    ProtoNet protein and cluster: O60682

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for MSC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
    Function: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in
    regulating antigen-dependent B-cell differentiation

         Genatlas biochemistry entry for MSC:
    activated B cell factor 1,musculin,mouse homolog,predominantly expressed in a subset of lymphoid tissues in adult and
    activated B cells,maybe involved in regulating antigen-dependent B cell differentiation

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MSC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSC
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MSC:
    hsa-miR-132* hsa-miR-149 hsa-miR-513a-3p hsa-miR-3605-3p hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: MSC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSC (see all 4)
    OriGene shRNA RFP: MSC
    OriGene siRNA: MSC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MSC

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MSC (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSC
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MSC (NM_005098)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSC 

    Cell Line
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    Search LifeMap BioReagents cell lines for MSC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSC

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9584154
    GO:0003714transcription corepressor activity TAS9584154
    GO:0046983protein dimerization activity IEA--


    MSC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Msctm1Eno for MSC
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Msc):
     craniofacial  digestive/alimentary  mortality/aging  muscle  normal 

    MSC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MSC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Id Signaling Pathway
    		Id Signaling Pathway1.00


    1 BioSystems Pathway for MSC 
        Id Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MSC

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for MSC (O606822, 3 ENSP000003214454) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF12Q990813, ENSP000003310574I2D: score=1 STRING: ENSP00000331057
    ID2Q023633, ENSP000002340914I2D: score=2 STRING: ENSP00000234091
    TCF3P159233, ENSP000002629654I2D: score=2 STRING: ENSP00000262965
    TCF4P158843, ENSP000003464404I2D: score=2 STRING: ENSP00000346440
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS9584154
    GO:0014707branchiomeric skeletal muscle development IEA--
    GO:0060021palate development IEA--
    GO:0060539diaphragm development IEA--


    MSC for ontologies           About GeneDecksing



    Drugs & Compounds
    for MSC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSC
    Search CenterWatch for drugs/clinical trials and news about MSC / MUSC 

    Transcripts
    for MSC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MSC gene: 
    NM_005098.3  

    Unigene Cluster for MSC:

    Musculin
    Hs.442619  [show with all ESTs]
    Unigene Representative Sequence: NM_005098
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325509(uc003xyx.1) ENST00000518440 ENST00000521739

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MSC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSC
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MSC:
    hsa-miR-132* hsa-miR-149 hsa-miR-513a-3p hsa-miR-3605-3p hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: MSC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MSC (see all 4)
    OriGene shRNA RFP: MSC
    OriGene siRNA: MSC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSC
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MSC
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MSC (NM_005098)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSC 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSC

    Additional cDNA sequence: 

    AF060154.1 AF087036.1 AK313102.1 BC006313.2 BC067827.1 BT007169.1 

    7 DOTS entries:

    DT.441856  DT.102831245  DT.202475  DT.92427684  DT.92427683  DT.100682158  DT.92427679 

    24/132 AceView cDNA sequences (see all 132):

    AW241565 AI298650 CB217106 AI651393 BX115600 CA443950 AI583179 BC067827 
    BM725166 BP374600 CD367304 AI380115 AI819367 CR594663 CR593021 CR622554 
    BC006313 CD366733 AA732935 CA423951 CD366829 CB993931 AI924582 BI759659 

    GeneLoc Exon Structure


    Expression
    for MSC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCATTCGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MSC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    Head MesenchymeBranchial Arch 2Paraxial Mesoderm CellsSkeletal Muscle
    Head MesenchymeHead MesenchymeParaxial Mesoderm CellsBone, Skeletal Muscle
    Skeletal MuscleExtraocular MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Head MesenchymePrechordal MesenchymePrechordal Mesoderm CellsSkeletal Muscle
    Skeletal MuscleExtraocular MusclesMultinuclear MyocyteSkeletal Muscle
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    BoneMandibular ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See MSC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSC

    SOURCE GeneReport for Unigene cluster: Hs.442619

    UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
    Tissue specificity: Expressed in lymphoid tissues, B-cell lines and activated B-cells

        SABiosciences Expression via Pathway-Focused PCR Array including MSC: 
              Notch Signaling Targets in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSC
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSC

    Orthologs
    for MSC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MSC gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MSC1 musculin 77.89(n)
    77.89(a)    		   420179  XM_418293.3  XP_418293.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MSC6
    		 --
    		 61(a)
    		 1 ↔ 1
    		 4(32939876-32946819)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5563961 transcription factor 21-like 63.75(n)
    67.5(a)    		   556396  XM_679187.5  XP_684279.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta HLH54F6
    		 HLH54F
    		 20(a)
    		 1 → many
    		 2R(13644922-13648022)


    ENSEMBL Gene Tree for MSC (if available)
    TreeFam Gene Tree for MSC (if available) 

    Paralogs
    for MSC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSC gene
    TCF242  NHLH12  TWIST12  TAL12  TWIST22  HAND22  TCF232  LYL12  
    NHLH22  TAL22  TCF152  SCXB2  TCF212  HAND12  SCXA2  
    1 SIMAP similar gene for MSC using alignment to 1 protein entry:     MUSC_HUMAN:
    TCF21

    MSC for paralogs           About GeneDecksing



    Genomic Variants
    for MSC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 NCBI SNPs in MSC are shown (see all 99)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1844994141,2
    		--72753305(+) GAAAAG/TCACCG 1 -- ds50010--------
    rs1896384371,2
    		--72753397(+) TTTTTG/TAACTA 2 -- ds5001 us2k10--------
    rs1819361641,2
    		--72753428(+) AGTGTA/GCTTTT 2 -- us2k1 ds50010--------
    rs1495264291,2
    		C,--72753449(+) TGTGT-/TGTG  
                TGTGT     		2 -- us2k1 ds50010--------
    rs362124951,2
    		C,--72753458(+) TGTGT-/TGT   
       GTGTG    TGTGT     		2 -- us2k1 ds50010--------
    rs1845224941,2
    		--72753471(+) TGTGTG/TTGTGT 2 -- ds5001 us2k10--------
    rs2019553821,2
    		--72753479(+) GTGTG-/TATATGA 2 -- ds5001 us2k10--------
    rs558781521,2
    		C--72753480(+) TGTGTGTGT/-  
                ATGAG     		2 -- ds5001 us2k11Minor allele frequency- -:0.00NA 2
    rs9001271,2
    		C,F,O,H,--72753497(-) AACATA/GGGTGC 2 -- us2k1 ds500120Minor allele frequency- G:0.31NA EA MN NS WA CSA 1356
    rs765355361,2
    		F,--72753560(+) TTTTAT/CTAGGC 2 -- us2k1 ds50011Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for MSC (72753777 - 72756731 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MSC
         1 CNV: 7705

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MSC
    DNA2.0 Custom Variant and Variant Library Synthesis for MSC

    Disorders / Diseases
    for MSC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MSC for disorders           About GeneDecksing

    OMIM gene information: 603628    OMIM disorders: --

    8 diseases for MSC:    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas    dendritic cell thymoma    cerebral artery occlusion
    burkitt's lymphoma    follicular lymphoma    rhabdomyosarcoma    cerebritis

    1 disease from the University of Copenhagen DISEASES database for MSC:
    Hodgkin's lymphoma
    Human Genome Epidemiology (HuGE) Navigator: MSC (58 documents)

    Export disorders for MSC gene to outside databases

    Publications
    for MSC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSC gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MSC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. (PubMed id 9584154)1, 2, 3, 9 Massari M.E.... Murre C. (1998)
    2. Musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle. (PubMed id 9767165)1, 2, 9 Robb L.... Begley C.G. (1998)
    3. Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1. (PubMed id 10198176)1, 3, 9 Robb L....Harvey R.P. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1. (PubMed id 15052269)1, 9 Knight J.C....Kwiatkowski D.P. (2004)
    6. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    7. ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma. (PubMed id 18368067)1 Ushmorov A....Wirth T. (2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for MSC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MSC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9242 HGNC: 7321 AceView: MSC Ensembl:ENSG00000178860 euGenes: HUgn9242
    ECgene: MSC H-InvDB: MSC

    Other Databases showing MSC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MSC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MSC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MSC gene:
    Search GeneIP for patents involving MSC

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    Products
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