Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSC Gene

protein-coding   GIFtS: 58
GCID: GC08M072803

Musculin

(Previous name: musculin (activated B-cell factor-1))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
musculin1 2     Musculin (Activated B-Cell Factor-1)1
Activated B-Cell Factor-11 2     MYOR2
Class A Basic Helix-Loop-Helix Protein 222 3     Activated B-Cell Factor 1, Homolog Of Mouse Musculin2
ABF-12 3     BHLHA223
ABF12 3     Activated B-Cell Factor 13
bHLHa222 3     

External Ids:    HGNC: 73211   Entrez Gene: 92422   Ensembl: ENSG000001788607   OMIM: 6036285   UniProtKB: O606823   

Export aliases for MSC gene to outside databases

Previous GC identifers: GC08M071836 GC08M072694 GC08M072476 GC08M072916 GC08M068248


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MSC Gene:
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a
homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in
vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian
cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MSC Gene: 
MSC (musculin) is a protein-coding gene. Diseases associated with MSC include dendritic cell thymoma, and follicular lymphoma. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TCF24.

UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
Function: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a
role in regulating antigen-dependent B-cell differentiation

Gene Wiki entry for MSC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MSC gene promoter:
         HFH-3   AP-1   ATF-2   MyoD   IRF-1   C/EBPalpha   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMSC promoter sequence
   Search SABiosciences Chromatin IP Primers for MSC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q13.3

MSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSC gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M072803:  view genomic region     (about GC identifiers)

Start:
72,753,777 bp from pter      End:
72,756,731 bp from pter
Size:
2,955 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682 (See protein sequence)
Recommended Name: Musculin  
Size: 206 amino acids; 22068 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a
heterodimer. Forms a heterodimer with TCF3
Subcellular location: Nucleus
Sequence caution: Sequence=AAC15071.1; Type=Frameshift; Positions=189;
Secondary accessions: O75946 Q53XZ2 Q9BRE7

Explore the universe of human proteins at neXtProt for MSC: NX_O60682

Explore proteomics data for MSC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60682

  • MSC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MSC Protein Expression
    REFSEQ proteins: NP_005089.2  
    ENSEMBL proteins: 
     ENSP00000321445  

    Human Recombinant Protein Products for MSC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MSC
    OriGene Protein Over-expression Lysate for MSC
    OriGene MassSpec for MSC 
    OriGene Custom Protein Services for MSC
    GenScript Custom Purified and Recombinant Proteins Services for MSC
    Novus Biologicals MSC Proteins
    Novus Biologicals MSC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MSC 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MSC for ontologies           About GeneDecksing



    MSC Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MSC
    GenScript Custom Superior Antibodies Services for MSC
    Novus Biologicals MSC Antibodies
    Abcam antibodies for MSC
    Cloud-Clone Corp. Antibodies for MSC 
    ThermoFisher Antibodies for MSC
    LSBio Antibodies in human, mouse, rat for MSC 

    Assay Products for MSC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MSC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MSC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MSC 
    Cloud-Clone Corp. CLIAs for MSC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry O60682

    ProtoNet protein and cluster: O60682

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    MSC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MUSC_HUMAN, O60682
    Function: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a
    role in regulating antigen-dependent B-cell differentiation

         Genatlas biochemistry entry for MSC:
    activated B cell factor 1,musculin,mouse homolog,predominantly expressed in a subset of lymphoid tissues in adult
    and activated B cells,maybe involved in regulating antigen-dependent B cell differentiation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9584154
    GO:0003714transcription corepressor activity TAS9584154
    GO:0046983protein dimerization activity IEA--
         
    MSC for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Msc):
     craniofacial  digestive/alimentary  mortality/aging  muscle  normal 

    MSC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Msctm1Eno for MSC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MSC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MSC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MSC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MSC 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSC
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MSC:
    hsa-miR-132* hsa-miR-149 hsa-miR-513a-3p hsa-miR-3605-3p hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidMSC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MSC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MSC
    Sirion Biotech Customized adenovirus for overexpression of MSC

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MSC (see all 7)
    OriGene ORF clones in mouse, rat for MSC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSC (NM_005098)
    Sino Biological Human cDNA Clone for MSC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSC
    Sirion Biotech Customized lentivirus for stable overexpression of MSC 
                         Customized lentivirus expression plasmids for stable overexpression of MSC 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MSC
    Search LifeMap BioReagents cell lines for MSC
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MSC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Id Signaling Pathway
    Id Signaling Pathway


    1 BioSystems Pathway for MSC
        Id Signaling Pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MSC

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for MSC (O606822, 3 ENSP000003214454) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF12Q990813, ENSP000003310574I2D: score=1 STRING: ENSP00000331057
    ID2Q023633, ENSP000002340914I2D: score=2 STRING: ENSP00000234091
    TCF3P159233, ENSP000002629654I2D: score=2 STRING: ENSP00000262965
    TCF4P158843, ENSP000003464404I2D: score=2 STRING: ENSP00000346440
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS9584154
    GO:0014707branchiomeric skeletal muscle development IEA--
    GO:0060021palate development IEA--
    GO:0060539diaphragm development IEA--

    MSC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSC (MUSC)

    Search CenterWatch for drugs/clinical trials and news about MSC / MUSC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSC gene: 
    NM_005098.3  

    Unigene Cluster for MSC:

    Musculin
    Hs.442619  [show with all ESTs]
    Unigene Representative Sequence: NM_005098
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325509(uc003xyx.1) ENST00000518440 ENST00000521739
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MSC
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MSC:
    hsa-miR-132* hsa-miR-149 hsa-miR-513a-3p hsa-miR-3605-3p hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidMSC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MSC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSC
    Clone
    Products:
         
    OriGene clones in human, mouse for MSC (see all 7)
    OriGene ORF clones in mouse, rat for MSC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MSC (NM_005098)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSC
    Sirion Biotech Customized lentivirus for stable overexpression of MSC 
                         Customized lentivirus expression plasmids for stable overexpression of MSC 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MSC
    OriGene qSTAR qPCR primer pairs in human, mouse for MSC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSC

    Additional mRNA sequence: 

    AF060154.1 AF087036.1 AK313102.1 BC006313.2 BC067827.1 BT007169.1 

    7 DOTS entries:

    DT.441856  DT.102831245  DT.202475  DT.92427684  DT.92427683  DT.100682158  DT.92427679 

    24/132 AceView cDNA sequences (see all 132):

    AI651393 AI819367 BC006313 BM725166 CD367304 CB217106 CA443950 CR622554 
    CR593021 BC067827 BX115600 AI298650 AW241565 AI380115 AI583179 BP374600 
    CR594663 CD366733 BE219050 CB993931 BE385373 AW136692 BX378647 BX343801 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSC expression in normal human tissues (normalized intensities)      MSC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCATTCGTG
    MSC Expression
    About this image


    MSC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
             Human Skeletal Muscle Cells (HSkMC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor ES-198
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 4 entries
             Paraxial Mesoderm Cells Head Mesenchyme
     
     Fibroblast (Uncategorized)    fully expand to see all 3 entries
             Human Prostate Fibroblasts (HPrF)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived mesenchymal stem cells
             cd49a+ cells   

    See MSC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSC

    SOURCE GeneReport for Unigene cluster: Hs.442619

    UniProtKB/Swiss-Prot: MUSC_HUMAN, O60682
    Tissue specificity: Expressed in lymphoid tissues, B-cell lines and activated B-cells

        SABiosciences Expression via Pathway-Focused PCR Array including MSC: 
              Notch Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MSC
    OriGene qSTAR qPCR primer pairs in human, mouse for MSC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MSC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MSC gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msc1 , 5 musculin1, 5 84.91(n)1
    86.57(a)1
      1 (4.50 cM)5
    176811  NM_010827.21  NP_034957.11 
     147533465 
    chicken
    (Gallus gallus)
    Aves MSC1 musculin 77.89(n)
    77.89(a)
      420179  XM_418293.3  XP_418293.3 
    lizard
    (Anolis carolinensis)
    Reptilia MSC6
    Uncharacterized protein
    49(a)
    1 ↔ 1
    4(32939876-32946819)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5563961 transcription factor 21-like 63.75(n)
    67.5(a)
      556396  XM_679187.5  XP_684279.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta HLH54F6
    HLH54F
    20(a)
    1 → many
    2R(13644922-13648022)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-106
    Protein HLH-10
    20(a)
    1 → many
    V(9280702-9282154)


    ENSEMBL Gene Tree for MSC (if available)
    TreeFam Gene Tree for MSC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSC gene
    TCF242  TCF232  TCF212  
    1 SIMAP similar gene for MSC using alignment to 1 protein entry:     MUSC_HUMAN:
    TCF21

    MSC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in MSC are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844994141,2
    --72753305(+) GAAAAG/TCACCG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MSC (72753777 - 72756731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MSC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737154CNV Deletion23290073
    esv33409CNV Loss17666407
    nsv831353CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MSC
    DNA2.0 Custom Variant and Variant Library Synthesis for MSC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603628    OMIM disorders: --

    10 diseases for MSC:    About MalaCards
    dendritic cell thymoma    follicular lymphoma    cerebral artery occlusion    diffuse large b-cell lymphoma
    b-cell lymphomas    thymoma    burkitt's lymphoma    rhabdomyosarcoma
    cerebritis    hodgkin's lymphoma

    1 disease from the University of Copenhagen DISEASES database for MSC:
    Hodgkin's lymphoma

    MSC for disorders           About GeneDecksing

    Genetic Association Database (GAD): MSC
    Human Genome Epidemiology (HuGE) Navigator: MSC (58 documents)

    Export disorders for MSC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSC gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MSC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. (PubMed id 9584154)1, 2, 3, 9 Massari M.E.... Murre C. (1998)
    2. Musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle. (PubMed id 9767165)1, 2, 9 Robb L.... Begley C.G. (1998)
    3. Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1. (PubMed id 10198176)1, 3, 9 Robb L....Harvey R.P. (1999)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1. (PubMed id 15052269)1, 9 Knight J.C....Kwiatkowski D.P. (2004)
    7. ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma. (PubMed id 18368067)1 Ushmorov A....Wirth T. (2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9242 HGNC: 7321 AceView: MSC Ensembl:ENSG00000178860 euGenes: HUgn9242
    ECgene: MSC H-InvDB: MSC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSC gene:
    Search GeneIP for patents involving MSC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MSC  
     OriGene qPCR primer pairs and template standards for MSC   OriGene Protein Over-expression Lysate for MSC  
     OriGene MassSpec something-or-other for MSC   OriGene clones in human, mouse for MSC  
     OriGene qSTAR qPCR primer pairs in human, mouse for MSC   OriGene Purified Protein for MSC  
     OriGene ORF clones in mouse, rat for MSC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MSC   OriGene Custom Protein Services for MSC  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MSC
     QIAGEN SeqTarget long-range PCR primers for resequencing MSC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSC
     GenScript Custom Purified and Recombinant Proteins Services for MSC GenScript cDNA clones with any tag delivered in your preferred vector for MSC
     GenScript Custom Assay Services for MSC GenScript Custom Superior Antibodies Services for MSC
     GenScript Custom overexpressing Cell Line Services for MSC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MSC promoter
     Search Chromatin IP Primers for MSC
     RT2 qPCR Primer Assay in human, mouse, rat MSC
     GNC Network for MSC
     SABiosciences PCR Arrays including human, mouse, rat MSC
     Search Tocris compounds for MSC (MUSC)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for MSC
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MSC antibodies
     MSC proteins
     MSC lysates
     Antibodies for MSC
     See all of Abcam's Antibodies, Kits and Proteins for MSC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MSC
     Antibodies for MSC
     ELISAs for MSC
     CLIAs for MSC
     Search LifeMap BioReagents cell lines for MSC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSC
     SwitchGear 3'UTR luciferase reporter plasmids for MSC
     SwitchGear Promoter luciferase reporter plasmids for MSC
     ThermoFisher Antibodies for MSC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSC
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MSC
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MSC
    Customized:
     lentivirus for stable overexpression of MSC
     lentivirus expression plasmids for stable overexpression of MSC
     adenovirus for overexpression of MSC
     LSBio Antibodies in human, mouse, rat for MSC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MSC gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4