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MSBP2 Gene

protein-coding   GIFtS: 12
GCID: GC00U990214

Minisatellite Binding Protein 2, 77kDa

(Previous name: minisatellite binding protein 2 (77kD))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Minisatellite Binding Protein 2, 77kDa1 2
Minisatellite Binding Protein 2 (77kD)1

External Ids:    HGNC: 73191   Entrez Gene: 44322   

Export aliases for MSBP2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MSBP2 Gene:
MSBP2 (minisatellite binding protein 2, 77kDa) is a protein-coding gene. Diseases associated with MSBP2 include vascular dementia, and choroiditis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MSBP2
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSBP2


Genomic Location:
Chromosome:--   

       


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSBP2
Interactions:

    Search GeneGlobe Interaction Network for MSBP2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MSBP2

9 Novoseek inferred chemical compound relationships for MSBP2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
sterol 85.8 46 18579430 (2), 20138838 (2), 17604677 (2), 12580245 (1) (see all 38)
cholesterol 55.6 14 18579430 (2), 14685799 (1), 18080173 (1), 19808779 (1) (see all 13)
acetyl-coa 36.6 1 20138838 (1)
lipid 31.1 4 18287352 (1), 20138838 (1), 16227610 (1), 15211801 (1)
leucine 30.9 3 15044019 (1), 10535306 (1), 11478948 (1)
fatty acid 26.4 3 15226391 (1), 16990341 (1), 9508001 (1)
dihydrotestosterone 22.6 1 16990341 (1)
zinc 17.2 2 9443972 (1), 14587307 (1)
tyrosine 0 2 17558859 (1), 19808789 (1)



MSBP2 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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miRNA
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Inhib. RNA
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Clone
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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MSBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MSBP2
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MSBP2
DNA2.0 Custom Variant and Variant Library Synthesis for MSBP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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17 diseases for MSBP2:    About MalaCards
vascular dementia    choroiditis    transitional cell carcinoma    dementia
alzheimer's disease    tuberculosis    astrocytoma    endotheliitis
hiv-1    obesity    ovarian cancer    prostate cancer
prostatitis    neuronitis    breast cancer    hepatitis
leukemia


MSBP2 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

5 Novoseek inferred disease relationships for MSBP2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell 27.1 1 15044019 (1)
alzheimers disease 26.1 2 19276544 (1)
inflammation 0 1 9290026 (1)
tumors 0 1 14871828 (1)
cancer 0 1 11149418 (1)


Export disorders for MSBP2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MSBP2 gene, integrated from 10 sources (see all 84):
(articles sorted by number of sources associating them with MSBP2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Two hypervariable minisatellite DNA binding proteins. (PubMed id 2062643)1, 3 Wahls W.P....Moore P.D. (Nucleic Acids Res. 1991)
  2. O-GlcNAc inhibits interaction between Sp1 and sterol regulatory element binding protein 2. (PubMed id 20138838)9 Lim K. and Chang H.I. (Biochem. Biophys. Res. Commun. 2010)
  3. Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia. (PubMed id 18853460)9 Sleegers K....Van Broeckhoven C. (Hum. Mutat. 2009)
  4. Overexpression of A-kinase anchoring protein 12A activates sterol regulatory element binding protein-2 and enhances cholesterol efflux in hepatic cells. (PubMed id 18579430)9 Choi M.C....Bang Y.J. (amp 2008)
  5. Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. (PubMed id 17604677)9 Colgan S.M....Austin R.C. (amp 2007)
  6. Immunohistochemical study of surgically excised choroidal neovascular membranes. (PubMed id 14587307)9 Sato T....Hoshino Y. (J. Int. Med. Res. 2003)
  7. The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP). (PubMed id 11478948)9 Gachon F....Mesnard J. (FEBS Lett. 2001)
  8. Nuclear targeting of cAMP response element binding protein 2 (CREB2). (PubMed id 10535306)9 Cibelli G....Thiel G. (Eur. J. Cell Biol. 1999)
  9. The role of insulin-like growth factor (IGF) binding protein-2 in the insulin-mediated decrease in IGF-I bioactivity. (PubMed id 19846739)9 Arafat A.M....Pfeiffer A.F. (J. Clin. Endocrinol. Metab. 2009)
  10. IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK. (PubMed id 18952587)9 Becher O.J....MacDonald T.J. (J. Child Neurol. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4432 HGNC: 7319 euGenes: HUgn4432 ECgene: MSBP2 H-InvDB: MSBP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MSBP2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MSBP2 gene:
Search GeneIP for patents involving MSBP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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