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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSANTD4 Gene

protein-coding   GIFtS: 42
GCID: GC11M105866

Myb/SANT-Like DNA-Binding Domain Containing 4 With Coiled-Coils

(Previous name: KIAA1826)
(Previous symbol: KIAA1826)
  Search for MSANTD4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myb/SANT-Like DNA-Binding Domain Containing 4 With Coiled-Coils1 2 3
KIAA18261 2 3
Myb/SANT-Like DNA-Binding Domain-Containing Protein 42

External Ids:    HGNC: 293831   Entrez Gene: 844372   Ensembl: ENSG000001709037   UniProtKB: Q8NCY63   

Export aliases for MSANTD4 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MSANTD4 Gene: 
MSANTD4 (Myb/SANT-like DNA-binding domain containing 4 with coiled-coils) is a protein-coding gene.

Gene Wiki entry for MSANTD4 (KIAA1826) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MSANTD4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MSANTD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSANTD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22

MSANTD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSANTD4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M105866:  view genomic region     (about GC identifiers)

Start:
105,866,350 bp from pter      End:
105,893,130 bp from pter
Size:
26,781 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MSD4_HUMAN, Q8NCY6 (See protein sequence)
Recommended Name: Myb/SANT-like DNA-binding domain-containing protein 4  
Size: 345 amino acids; 41150 Da
Sequence caution: Sequence=AAG44625.1; Type=Frameshift; Positions=122, 225; Sequence=BAB47455.1; Type=Erroneous
initiation; Sequence=BAB55371.1; Type=Erroneous initiation;
Secondary accessions: Q96JK1 Q96JZ3 Q9H2N4

Explore the universe of human proteins at neXtProt for MSANTD4: NX_Q8NCY6

Explore proteomics data for MSANTD4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NCY6

  • MSANTD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MSANTD4 Protein Expression
    REFSEQ proteins: NP_115800.1  
    ENSEMBL proteins: 
     ENSP00000304713   ENSP00000435125   ENSP00000432245   ENSP00000435372  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    MSANTD4 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026162 MSANTD4

    Graphical View of Domain Structure for InterPro Entry Q8NCY6

    ProtoNet protein and cluster: Q8NCY6

    UniProtKB/Swiss-Prot: MSD4_HUMAN, Q8NCY6
    Similarity: Contains 1 Myb-like domain


    MSANTD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
         
    MSANTD4 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSANTD4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MSANTD4 (Q8NCY63 ENSP000003047134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSANTD4 (MSD4)

    Search CenterWatch for drugs/clinical trials and news about MSANTD4 / MSD4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSANTD4 gene: 
    NM_032424.1  

    Unigene Cluster for MSANTD4:

    Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
    Hs.266782  [show with all ESTs]
    Unigene Representative Sequence: NM_032424
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529805 ENST00000301919(uc001piy.3 uc001piz.3) ENST00000530788
    ENST00000534458 ENST00000530108
    miRNA
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    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for MSANTD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MSANTD4
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MSANTD4
    Sirion Biotech Customized lentivirus for stable overexpression of MSANTD4 
                         Customized lentivirus expression plasmids for stable overexpression of MSANTD4 
    Primer
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    OriGene qPCR primer pairs and template standards for MSANTD4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MSANTD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MSANTD4

    Additional mRNA sequence: 

    AB058729.1 AF253976.1 AK027790.1 AK293050.1 AL834523.1 BC041118.1 

    9 DOTS entries:

    DT.407028  DT.100035733  DT.100668540  DT.426602  DT.120728060  DT.100650633  DT.99986623  DT.100716957 
    DT.40214313 

    24/83 AceView cDNA sequences (see all 83):

    AB058729 CR610578 BM674853 BX279748 BC041118 BM454665 CN484047 AL521499 
    AA443382 BX504497 AK027790 BQ187206 CR614328 BM466510 AL834523 Z40813 
    AI274543 BM755366 BF432733 BQ008462 AI014830 BQ224308 BQ019579 AW195006 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MSANTD4    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b
    SP1:                                                                  
    SP2:              -     -     -                                       
    SP3:                    -     -                                       
    SP4:                          -                                       
    SP5:                          -                                       


    ECgene alternative splicing isoforms for MSANTD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSANTD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTTGAACC
    MSANTD4 Expression
    About this image


    See MSANTD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSANTD4

    SOURCE GeneReport for Unigene cluster: Hs.266782
        SABiosciences Custom PCR Arrays for MSANTD4
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSANTD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MSANTD4 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msantd45
    Mysantd41
    RIKEN cDNA 8430410K20 gene5
    Myb/SANT-like DNA-binding domain containing 4 with more1
    85.56(n)1
    95.35(a)1
      9 (2.46 cM)5
    781001  NM_145609.11  NP_663584.11 
     43835355 
    chicken
    (Gallus gallus)
    Aves MSANTD41 Myb/SANT-like DNA-binding domain containing 4 with more 75.19(n)
    79.07(a)
      418977  XM_417171.3  XP_417171.2 
    lizard
    (Anolis carolinensis)
    Reptilia MSANTD46
    Uncharacterized protein
    79(a)
    1 ↔ 1
    3(190363241-190368150)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137872 Xenopus laevis transcribed sequence with weak similarity more 74.12(n)    CA972684.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5705861 coiled-coil domain-containing protein KIAA1826 homolog 58.58(n)
    54.68(a)
      570586  XM_694083.4  XP_699175.3 


    ENSEMBL Gene Tree for MSANTD4 (if available)
    TreeFam Gene Tree for MSANTD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/272 SNPs in MSANTD4 are shown (see all 272)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500276261,2
    --105878176(+) TTCCAC/TGTGGC 1 -- ds50010--------
    rs1807292111,2
    --105878198(+) CATAAC/TCATGG 1 -- ds50010--------
    rs1864145591,2
    --105878288(+) AAACCA/GTCAGA 1 -- ds50010--------
    rs1488449451,2
    --105878358(+) TCAATC/TATTTT 1 -- ds50010--------
    rs1892471971,2
    --105878370(+) CACTGA/GGTCCC 1 -- ds50010--------
    rs108958911,2
    C,A--105878381(+) TCCCAC/TAACAC 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1392677351,2
    C--105878419(+) GATGA-/GA    
       TTTGG
    GTGAG
    1 -- ds50010--------
    rs1817143541,2
    C--105878419(+) GATGAG/TATTTG 1 -- ds50010--------
    rs1378792401,2
    --105878444(+) TAAACC/TGTATC 1 -- ds50010--------
    rs1411635211,2
    --105878473(+) GGGTTC/GTTTTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MSANTD4 (105866350 - 105893130 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MSANTD4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MSANTD4
    DNA2.0 Custom Variant and Variant Library Synthesis for MSANTD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSANTD4 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with MSANTD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    3. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    6. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84437 HGNC: 29383 AceView: KIAA1826 Ensembl:ENSG00000170903 euGenes: HUgn84437
    ECgene: MSANTD4 H-InvDB: MSANTD4

    (According to HUGE)
    About This Section
    HUGE: KIAA1826

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSANTD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSANTD4 gene:
    Search GeneIP for patents involving MSANTD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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