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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MSANTD2 Gene

protein-coding   GIFtS: 38
GCID: GC11M124637

Myb/SANT-Like DNA-Binding Domain Containing 2

(Previous name: chromosome 11 open reading frame 61)
(Previous symbol: C11orf61)
  Search for MSANTD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Myb/SANT-Like DNA-Binding Domain Containing 21 2
C11orf611 2 3
Chromosome 11 Open Reading Frame 611
Myb/SANT-Like DNA-Binding Domain-Containing Protein 22

External Ids:    HGNC: 262661   Entrez Gene: 796842   Ensembl: ENSG000001204587   UniProtKB: Q6P1R33   

Export aliases for MSANTD2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MSANTD2 Gene: 
MSANTD2 (Myb/SANT-like DNA-binding domain containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MSANTD2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MSANTD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MSANTD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

MSANTD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSANTD2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M124637:  view genomic region     (about GC identifiers)

Start:
124,636,394 bp from pter      End:
124,670,569 bp from pter
Size:
34,176 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MSD2_HUMAN, Q6P1R3 (See protein sequence)
Recommended Name: Myb/SANT-like DNA-binding domain-containing protein 2  
Size: 559 amino acids; 61319 Da
Secondary accessions: B3KRY6 Q9H042 Q9H5K8
Alternative splicing: 3 isoforms:  Q6P1R3-1   Q6P1R3-2   Q6P1R3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MSANTD2: NX_Q6P1R3

Explore proteomics data for MSANTD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P1R3

  • MSANTD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MSANTD2 Protein Expression
    REFSEQ proteins: NP_078907.2  
    ENSEMBL proteins: 
     ENSP00000239614   ENSP00000364118   ENSP00000435705   ENSP00000431707   ENSP00000434572  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6P1R3

    UniProtKB/Swiss-Prot: MSD2_HUMAN, Q6P1R3
    Similarity: Contains 1 Myb-like domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MSANTD2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MSANTD2 (Q6P1R32, 3 ENSP000002396144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STRN4Q9NRL32, 3MINT-65606 I2D: score=4 
    ERCC3ENSP000002853984STRING: ENSP00000285398
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MSANTD2 (MSD2)

    Search CenterWatch for drugs/clinical trials and news about MSANTD2 / MSD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MSANTD2 gene: 
    NM_024631.2  

    Unigene Cluster for MSANTD2:

    Myb/SANT-like DNA-binding domain containing 2
    Hs.146079  [show with all ESTs]
    Unigene Representative Sequence: AL512691
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000239614(uc001qaz.1 uc010sap.1) ENST00000374979(uc001qba.1)
    ENST00000526629(uc001qay.1) ENST00000524950 ENST00000533514 ENST00000527140

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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of MSANTD2 
    Primer
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    Additional mRNA sequence: 

    AK026995.1 AK092413.1 AK303902.1 AL512691.1 BC064919.1 

    5 DOTS entries:

    DT.75140066  DT.313788  DT.97834666  DT.100777127  DT.75175343 

    24/70 AceView cDNA sequences (see all 70):

    BP375342 BP376140 AL512691 AU280226 BP375857 BQ005450 BC064919 BQ421244 
    AA447088 AA009422 AK092413 BX102095 AA009726 AI251765 W69427 AI637952 
    BE463607 CF454514 AA491180 AA810427 BX352996 AI613451 AI802920 AI961083 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MSANTD2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d
    SP1:              -     -                       -                                       
    SP2:              -     -     -                 -                                       
    SP3:              -     -     -     -           -                                       
    SP4:                    -                       -                                       
    SP5:                                            -                                       


    ECgene alternative splicing isoforms for MSANTD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MSANTD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGTCAGC
    MSANTD2 Expression
    About this image


    See MSANTD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MSANTD2

    SOURCE GeneReport for Unigene cluster: Hs.146079
        SABiosciences Custom PCR Arrays for MSANTD2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MSANTD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MSANTD2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msantd21 , 5 cDNA sequence BC0244795
    Myb/SANT-like DNA-binding domain containing 21
    92.18(n)1
    96.45(a)1
      9 (20.77 cM)5
    2351841  NM_146222.21  NP_666334.21 
     374893215 
    chicken
    (Gallus gallus)
    Aves MSANTD21 Myb/SANT-like DNA-binding domain containing 2 79.97(n)
    88.22(a)
      768763  NM_001109786.1  NP_001103256.1 
    lizard
    (Anolis carolinensis)
    Reptilia MSANTD26
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL343367.1(81098-92736)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.225562 Xenopus laevis transcribed sequence with moderate similarity more 76.08(n)    48032271 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7993681 uncharacterized protein C11orf61 homolog 65.52(n)
    67.81(a)
      799368  XM_001339696.1  XP_001339732.1 


    ENSEMBL Gene Tree for MSANTD2 (if available)
    TreeFam Gene Tree for MSANTD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MSANTD2 gene

    MSANTD2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MSANTD2
    PGOHUM00000248680 PGOHUM00000258121


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/501 SNPs in MSANTD2 are shown (see all 501)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808957191,2
    --124635926(+) GAGTTC/TGAGAC 1 -- ds50010--------
    rs1862464221,2
    --124636129(+) AGTCTC/TTTACA 1 -- ds50010--------
    rs5345281,2
    H--124636199(+) ATTACA/CAAATG 1 -- ds50015Minor allele frequency- C:0.00MN NS EA 598
    rs1484281031,2
    C--124636219(+) GTGACC/TTTTGG 1 -- ds50010--------
    rs112197741,2
    C,F,A,H--124636373(+) CAAAAA/CGCTCA 1 -- ds500129Minor allele frequency- C:0.26NS EA NA WA CSA 3191
    rs1142685851,2
    C,F--124636500(+) ACTGAT/CTGGAA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs730314591,2
    C,F--124636645(+) GGGTTG/ATAAAT 1 -- ut311Minor allele frequency- A:0.02NA 120
    rs558429971,2
    C--124636672(+) CATAGA/GGATGT 1 -- ut310--------
    rs1425308751,2
    --124636737(+) AAAGTA/GTAAGT 1 -- ut310--------
    rs1891581111,2
    --124636751(+) GTCCAA/GTATGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MSANTD2 (124636394 - 124670569 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MSANTD2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MSANTD2
    DNA2.0 Custom Variant and Variant Library Synthesis for MSANTD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MSANTD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MSANTD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    5. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    7. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79684 HGNC: 26266 AceView: FLJ23342 Ensembl:ENSG00000120458 euGenes: HUgn79684
    ECgene: MSANTD2 H-InvDB: MSANTD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MSANTD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MSANTD2 gene:
    Search GeneIP for patents involving MSANTD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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