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MSANTD1 Gene

protein-coding   GIFtS: 33
GCID: GC04P003246

Myb/SANT-Like DNA-Binding Domain Containing 1

(Previous name: chromosome 4 open reading frame 44)
(Previous symbol: C4orf44)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myb/SANT-Like DNA-Binding Domain Containing 11 2
C4orf441 2 3
Chromosome 4 Open Reading Frame 441
Myb/SANT-Like DNA-Binding Domain-Containing Protein 12

External Ids:    HGNC: 337411   Entrez Gene: 3452222   Ensembl: ENSG000001889817   UniProtKB: Q6ZTZ13   
ORGUL members:         

Export aliases for MSANTD1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MSANTD1 Gene:
MSANTD1 (Myb/SANT-like DNA-binding domain containing 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MSANTD1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MSANTD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MSANTD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.2

MSANTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MSANTD1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003246:  view genomic region     (about GC identifiers)

Start:
3,246,096 bp from pter      End:
3,273,465 bp from pter
Size:
27,370 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MSD1_HUMAN, Q6ZTZ1 (See protein sequence)
Recommended Name: Myb/SANT-like DNA-binding domain-containing protein 1  
Size: 278 amino acids; 31632 Da
Sequence caution: Sequence=BAC86436.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: C9J6V0

Explore the universe of human proteins at neXtProt for MSANTD1: NX_Q6ZTZ1

Explore proteomics data for MSANTD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MSANTD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001036155.1  
    ENSEMBL proteins: 
     ENSP00000423547   ENSP00000411584   ENSP00000425405   ENSP00000420966  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026095 Myb/SANT-like_DNA-bd_dom_prot

    Graphical View of Domain Structure for InterPro Entry Q6ZTZ1

    ProtoNet protein and cluster: Q6ZTZ1

    UniProtKB/Swiss-Prot: MSD1_HUMAN, Q6ZTZ1
    Similarity: Contains 1 Myb-like domain


    Find genes that share domains with MSANTD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MSANTD1

    miRNA
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    miRTarBase miRNAs that target MSANTD1:
    hsa-mir-185-5p (MIRT045317), hsa-mir-10a-5p (MIRT047517)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MSANTD1
    Interactions:

        Search GeneGlobe Interaction Network for MSANTD1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for MSANTD1 (ENSP000004115844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIFM1ENSP000002872954STRING: ENSP00000287295
    BCS1LENSP000003522194STRING: ENSP00000352219
    COL4A3BPENSP000003698624STRING: ENSP00000369862
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MSANTD1 (MSD1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MSANTD1 gene (2 alternative transcripts): 
    NM_001012982.2  NM_001042690.1  

    Unigene Cluster for MSANTD1:

    Myb/SANT-like DNA-binding domain containing 1
    Hs.442291  [show with all ESTs]
    Unigene Representative Sequence: BC043530
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507492(uc003ggs.3) ENST00000438480 ENST00000505599 ENST00000510580

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      QuantiFast Probe-based Assays in human, mouse, rat MSANTD1

    Additional mRNA sequence: 

    BC043530.1 BC148247.1 

    3 DOTS entries:

    DT.70103624  DT.95361117  DT.92067551 

    17 AceView cDNA sequences:

    BM685293 BQ631148 AW451759 CK902132 L34977 BE883961 AI638012 AK126094 
    AV732579 AI084202 AI939362 BC043530 BQ188122 BI825907 AW025646 BM930776 
    AI699506 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MSANTD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAGGAGC
    MSANTD1 Expression
    About this image

    MSANTD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MSANTD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442291
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MSANTD1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Msantd11 , 5 RIKEN cDNA A930005I04 gene5
    Myb/SANT-like DNA-binding domain containing 11
    89.33(n)1
    89.21(a)1
      5 (17.94 cM)5
    4031741  NM_207277.11  NP_997160.11 
     349159155 
    chicken
    (Gallus gallus)
    Aves C4H4ORF441 chromosome 4 open reading frame, human C4orf44 69.6(n)
    78.54(a)
      422877  XM_004936197.1  XP_004936254.1 
    lizard
    (Anolis carolinensis)
    Reptilia MSANTD16
    Myb/SANT-like DNA-binding domain containing 1
    78(a)
    1 ↔ 1
    GL343236.1(2285539-2309831)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia msantd11 Myb/SANT-like DNA-binding domain containing 1 74.24(n)
    75.7(a)
      100485542  XM_002939222.2  XP_002939268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7984971 myb/SANT-like DNA-binding domain-containing protein more 58.91(n)
    52.24(a)
      798497  XM_001338901.2  XP_001338937.2 


    ENSEMBL Gene Tree for MSANTD1 (if available)
    TreeFam Gene Tree for MSANTD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MSANTD1 (see all 264)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831348591,2
    --3248831(+) GCAGCA/TCCAAG 1 -- us2k10--------
    rs1394138871,2
    --3248841(+) GGTGGA/GTTTGT 1 -- us2k10--------
    rs27982291,2
    C,H--3248870(-) GGGCCC/TCTACG 1 -- us2k112Minor allele frequency- T:0.01NA WA CSA EA 374
    rs1885966001,2
    C--3248907(+) GCTGTG/TCCCCC 1 -- us2k10--------
    rs1498796691,2
    C--3249008(+) GGTCCA/GTGCTG 1 -- us2k10--------
    rs1928340331,2
    --3249068(+) GCTTAC/TCCCTT 1 -- us2k10--------
    rs1156512451,2
    F--3249156(+) GGACCG/AGTCCC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs76741221,2
    C,F,H--3249248(+) ATCTGC/TAGGCA 1 -- us2k110Minor allele frequency- T:0.04NS EA NA CSA WA 650
    rs1449336281,2
    --3249257(+) CACTCC/TACAGA 1 -- us2k10--------
    rs1486424801,2
    --3249258(+) ACTCCA/GCAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MSANTD1 (3246096 - 3273465 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MSANTD1: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MSANTD1
    DNA2.0 Custom Variant and Variant Library Synthesis for MSANTD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MSANTD1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MSANTD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 345222 HGNC: 33741 AceView: LOC345222 Ensembl:ENSG00000188981 euGenes: HUgn345222
    ECgene: MSANTD1 H-InvDB: MSANTD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MSANTD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MSANTD1 gene:
    Search GeneIP for patents involving MSANTD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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