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Aliases for MS4A8 Gene

Aliases for MS4A8 Gene

  • Membrane Spanning 4-Domains A8 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 8B 2 3
  • Four-Span Transmembrane Protein 4 3 4
  • MS4A8B 3 4
  • 4SPAN4 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 8 2
  • Membrane-Spanning 4-Domains Subfamily A Member 8B 4
  • Membrane-Spanning 4-Domains Subfamily A Member 8 3
  • CD20L5 3
  • MS4A4 3

External Ids for MS4A8 Gene

Previous HGNC Symbols for MS4A8 Gene

  • MS4A8B

Previous GeneCards Identifiers for MS4A8 Gene

  • GC11P060469

Summaries for MS4A8 Gene

Entrez Gene Summary for MS4A8 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A8 Gene

MS4A8 (Membrane Spanning 4-Domains A8) is a Protein Coding gene. An important paralog of this gene is MS4A12.

UniProtKB/Swiss-Prot for MS4A8 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A8 Gene

Genomics for MS4A8 Gene

Regulatory Elements for MS4A8 Gene

Enhancers for MS4A8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F060683 0.5 ENCODE 16.7 -15.3 -15320 1.0 PKNOX1 MTA2 EBF1 TBX21 RAD51 IKZF1 MLLT1 SPI1 MS4A8 MS4A18 LOC105369321 LINC00301
GH11F060710 0.5 ENCODE 15.4 +12.4 12395 3.7 CTCF RAD21 MS4A8 MS4A10 CCDC86 ENSG00000255959 MS4A18 STX3
GH11F060717 0.5 ENCODE 15.3 +19.7 19705 3.0 CTCF STAT1 PKNOX1 ZNF680 TRIM22 CEBPB REST ZNF384 TBX21 RAD21 MS4A8 MS4A10 MS4A1 MS4A18 MS4A14
GH11F060566 0.2 Ensembl 14.8 -132.4 -132396 0.8 CTCF TRIM22 RAD21 MYC MS4A8 ENSG00000283601 MS4A13
GH11F060740 0.2 ENCODE 11.3 +41.2 41209 0.2 FOS MS4A8 CCDC86 ENSG00000255959 MS4A15 MS4A18
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MS4A8 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A8 Gene

60,699,574 bp from pter
60,715,811 bp from pter
16,238 bases
Plus strand

Genomic View for MS4A8 Gene

Genes around MS4A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A8 Gene

Proteins for MS4A8 Gene

  • Protein details for MS4A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 8
    Protein Accession:
    Secondary Accessions:
    • Q8TCA5

    Protein attributes for MS4A8 Gene

    250 amino acids
    Molecular mass:
    26290 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A8 Gene

Post-translational modifications for MS4A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A8 Gene

No data available for DME Specific Peptides for MS4A8 Gene

Domains & Families for MS4A8 Gene

Gene Families for MS4A8 Gene

Protein Domains for MS4A8 Gene

Suggested Antigen Peptide Sequences for MS4A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A8: view

Function for MS4A8 Gene

Molecular function for MS4A8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A8: view

Animal Model Products

miRNA for MS4A8 Gene

miRTarBase miRNAs that target MS4A8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A8 Gene

Localization for MS4A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A8 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MS4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A8: view

No data available for Subcellular locations from COMPARTMENTS for MS4A8 Gene

Pathways & Interactions for MS4A8 Gene

SuperPathways for MS4A8 Gene

No Data Available

Interacting Proteins for MS4A8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000300226 for MS4A8 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MS4A8 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A8 Gene

Transcripts for MS4A8 Gene

Unigene Clusters for MS4A8 Gene

Membrane-spanning 4-domains, subfamily A, member 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - - -

Relevant External Links for MS4A8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A8 Gene

mRNA expression in normal human tissues for MS4A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A8 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x23.2), Cervix - Endocervix (x7.8), Colon - Transverse (x5.7), and Fallopian Tube (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of MS4A8 Gene:


SOURCE GeneReport for Unigene cluster for MS4A8 Gene:


mRNA Expression by UniProt/SwissProt for MS4A8 Gene:

Tissue specificity: Expressed by hematopoietic tissues and cells lines.
genes like me logo Genes that share expression patterns with MS4A8: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MS4A8 Gene

Orthologs for MS4A8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A8B 34
  • 99.47 (n)
MS4A8 35
  • 99 (a)
(Bos Taurus)
Mammalia MS4A8B 34 35
  • 74.76 (n)
(Rattus norvegicus)
Mammalia Ms4a8 34
  • 73.2 (n)
(Mus musculus)
Mammalia Ms4a8a 34 16 35
  • 71.33 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
-- 35
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia MS4A8 35
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
-- 35
  • 34 (a)
-- 35
  • 31 (a)
(Danio rerio)
Actinopterygii ms4a17a.14 35
  • 32 (a)
FP015791.1 35
  • 31 (a)
ms4a17a.11 35
  • 31 (a)
ms4a17a.6 35
  • 31 (a)
ms4a17a.10 35
  • 30 (a)
ms4a17a.5 35
  • 30 (a)
si:dkey-77f5.10 35
  • 30 (a)
si:ch73-56d11.4 35
  • 29 (a)
ms4a17a.1 35
  • 28 (a)
ms4a17a.2 35
  • 28 (a)
ms4a17a.7 35
  • 28 (a)
si:ch73-56d11.3 35
  • 28 (a)
ms4a17a.4 35
  • 27 (a)
ms4a17c.1 35
  • 27 (a)
si:dkey-238j22.1 35
  • 27 (a)
ms4a17a.3 35
  • 26 (a)
ms4a17a.8 35
  • 25 (a)
ms4a17a.9 35
  • 25 (a)
ms4a17c.2 35
  • 24 (a)
ms4a17a.17 35
  • 22 (a)
si:dkey-174k12.3 35
  • 22 (a)
Species where no ortholog for MS4A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A8 Gene

Gene Tree for MS4A8 (if available)
Gene Tree for MS4A8 (if available)

Paralogs for MS4A8 Gene

Paralogs for MS4A8 Gene

(7) SIMAP similar genes for MS4A8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MS4A8: view

Variants for MS4A8 Gene

Sequence variations from dbSNP and Humsavar for MS4A8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111482488 -- 60,709,389(+) TTAAA(-/AGAG)AGAGA intron-variant
rs111523940 -- 60,704,859(+) AAACA(A/C)ACACA intron-variant, upstream-variant-2KB
rs111565778 -- 60,697,636(+) TTTGC(C/T)GAAGT intron-variant, upstream-variant-2KB
rs111606832 -- 60,703,943(+) AATGA(C/T)GGTTT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111635154 -- 60,699,123(+) CTATT(A/C)CATGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MS4A8 Gene

Variant ID Type Subtype PubMed ID
esv2744575 CNV deletion 23290073
nsv1051057 CNV loss 25217958
nsv832175 CNV gain 17160897

Variation tolerance for MS4A8 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A8 Gene

Disorders for MS4A8 Gene

Relevant External Links for MS4A8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A8 Gene

Publications for MS4A8 Gene

  1. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K. … Imai M. (Gene 2001) 2 3 64
  4. Identification of the novel differentiation marker MS4A8B and its murine homolog MS4A8A in colonic epithelial cells lost during neoplastic transformation in human colon. (PMID: 23348583) Michel J. … Schmieder A. (Cell Death Dis 2013) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for MS4A8 Gene

Sources for MS4A8 Gene

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