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MS4A8 Gene

protein-coding   GIFtS: 38
GCID: GC11P060469

Membrane-Spanning 4-Domains, Subfamily A, Member 8

(Previous names: membrane-spanning 4-domains, subfamily A, member 8B)
(Previous symbol: MS4A8B)
  Search for MS4A8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 81 2     CD20L52
MS4A8B1 2 3 5     MS4A42
Membrane-Spanning 4-Domains, Subfamily A, Member 8B1 2     Membrane-Spanning 4-Domains Subfamily A Member 82
Four-Span Transmembrane Protein 42 3     Membrane-Spanning 4-Domains Subfamily A Member 8B3
4SPAN42 3     

External Ids:    HGNC: 133801   Entrez Gene: 836612   Ensembl: ENSG000001669597   OMIM: 6065495   UniProtKB: Q9BY193   

Export aliases for MS4A8 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MS4A8 Gene:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are
characterized by common structural features and similar intron/exon splice boundaries and display unique
expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is
localized to 11q12.3, among a cluster of family members. (provided by RefSeq, Jul 2008)

GeneCards Summary for MS4A8 Gene:
MS4A8 (membrane-spanning 4-domains, subfamily A, member 8) is a protein-coding gene. An important paralog of this gene is MS4A18.

UniProtKB/Swiss-Prot: M4A8_HUMAN, Q9BY19
Function: May be involved in signal transduction as a component of a multimeric receptor complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MS4A8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A8 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MS4A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12

MS4A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060469:  view genomic region     (about GC identifiers)

Start:
60,467,047 bp from pter      End:
60,483,284 bp from pter
Size:
16,238 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: M4A8_HUMAN, Q9BY19 (See protein sequence)
Recommended Name: Membrane-spanning 4-domains subfamily A member 8  
Size: 250 amino acids; 26290 Da
Secondary accessions: Q8TCA5

Explore the universe of human proteins at neXtProt for MS4A8: NX_Q9BY19

REFSEQ proteins: NP_113645.1  
ENSEMBL proteins: 
 ENSP00000300226   ENSP00000436857   ENSP00000435567   ENSP00000433200  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007237 CD20-like

Graphical View of Domain Structure for InterPro Entry Q9BY19

ProtoNet protein and cluster: Q9BY19

1 Blocks protein domain: IPB007237 CD20/IgE Fc receptor beta subunit

UniProtKB/Swiss-Prot: M4A8_HUMAN, Q9BY19
Similarity: Belongs to the MS4A family


MS4A8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: M4A8_HUMAN, Q9BY19
Function: May be involved in signal transduction as a component of a multimeric receptor complex

Animal Models:

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hsa-mir-335-5p (MIRT018776)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
M4A8_HUMAN, Q9BY19: Membrane; Multi-pass membrane protein

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

MS4A8 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MS4A8
Interactions:

    Search GeneGlobe Interaction Network for MS4A8

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MS4A8 (M4A8)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MS4A8 gene: 
NM_031457.1  

Unigene Cluster for MS4A8:

Membrane-spanning 4-domains, subfamily A, member 8
Hs.150878  [show with all ESTs]
Unigene Representative Sequence: AF237905
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000300226(uc001npv.3) ENST00000533691 ENST00000532953(uc009yne.1)
ENST00000533354 ENST00000450141 ENST00000529752 ENST00000532816 ENST00000534316
ENST00000525458
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Primer
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OriGene qPCR primer pairs and template standards for MS4A8
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  QuantiFast Probe-based Assays in human, mouse, rat MS4A8

Additional mRNA sequence: 

AF237905.1 AF350504.1 AK308413.1 AK310872.1 AK310884.1 AK310969.1 AK315901.1 BC022895.1 

8 DOTS entries:

DT.75101559  DT.97828465  DT.120700908  DT.40245398  DT.95225993  DT.100720872  DT.99928003  DT.86846737 

Selected AceView cDNA sequences (see all 64):

BU682967 BM818268 AW246731 AW770774 BU679374 CK902742 AW269806 BM980932 
BI116737 AI635015 NM_031457 BM768907 AA829284 AI299543 BM981874 CB305586 
AW151234 AA988639 BX090231 AI301176 AA887272 AF237905 AF350504 AI732978 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MS4A8 (see all 7)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1:                                -     -     -     -                             -     -                     
SP2:                    -           -     -     -     -                                                         
SP3:                                -     -                                                                     
SP4:                                -     -     -                                                               
SP5:                                      -     -     -                                                         


ECgene alternative splicing isoforms for MS4A8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MS4A8 expression in normal human tissues (normalized intensities)      MS4A8 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MS4A8 Expression
About this image


MS4A8 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Ovary (Reproductive System)
         Oviduct
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
 
 Stomach (Gastrointestinal Tract)
MS4A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.150878

UniProtKB/Swiss-Prot: M4A8_HUMAN, Q9BY19
Tissue specificity: Expressed by hematopoietic tissues and cells lines

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MS4A8 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ms4a8a1 , 5 membrane-spanning 4-domains, subfamily A, member 8A1, 5 71.33(n)1
60.4(a)1
  19 (7.62 cM)5
643811  NM_022430.21  NP_071875.21 
 110674725 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 3)
Uncharacterized protein
(see all 3)
36(a)
34(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
GL343235.1(162797-172173)
GL343235.1(114976-140922)
zebrafish
(Danio rerio)
Actinopterygii ms4a17a.146
ms4a17a.66
(see all 21)
membrane-spanning 4-domains, subfamily A, member 1...
membrane-spanning 4-domains, subfamily A, member 1...
(see all 21)
32(a)
31(a)
(see all 21)
many ↔ many
many ↔ many
(see all 21)
4(60581972-60613219) ENSDARG00000094809
4(60662692-60784616) ENSDARG00000007018


ENSEMBL Gene Tree for MS4A8 (if available)
TreeFam Gene Tree for MS4A8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MS4A8 gene
MS4A182  MS4A4A2  MS4A122  MS4A152  
7 SIMAP similar genes for MS4A8 using alignment to 4 protein entries:     M4A8_HUMAN (see all proteins):
MS4A18    MS4A1    MS4A12    MS4A15    MS4A5    MS4A4A
MS4A14

MS4A8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MS4A8 (see all 446)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs49394451,2
C,F,H--60465060(+) caagaC/ACTCCA 1 -- us2k15Minor allele frequency- A:0.03NS EA 538
rs1162090991,2
F--60465078(+) TCAAGG/AGGATA 1 -- us2k11Minor allele frequency- A:0.07WA 118
rs1115657781,2
C,F--60465109(+) TTTGCC/TGAAGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs618987981,2
F--60465122(+) GTTTGG/AACAAT 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs748273841,2
C,F--60465151(+) TCTCCG/AGTCCC 1 -- us2k12Minor allele frequency- A:0.20CSA WA 120
rs1464370391,2
C--60465152(+) CTCCGG/TTCCCT 1 -- us2k10--------
rs49394461,2
C,F,H--60465161(+) CTTCTA/TGAAAG 1 -- us2k1 tfbs326Minor allele frequency- N:0.00EA NA NS 2742
rs1393431291,2
--60465167(+) GAAAGC/TTGGCA 1 -- us2k10--------
rs1433443651,2
--60465190(+) ACTCAA/GTTAAA 1 -- us2k10--------
rs30214231,2
C,H--60465191(-) TTTTAA/CTTGAG 1 -- us2k14Minor allele frequency- C:0.00NS EA 418

HapMap Linkage Disequilibrium report for MS4A8 (60467047 - 60483284 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MS4A8: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MS4A8
DNA2.0 Custom Variant and Variant Library Synthesis for MS4A8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606549    OMIM disorders: --


MS4A8 for disorders           About GeneDecksing


Export disorders for MS4A8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MS4A8 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MS4A8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PubMed id 11401424)1, 2, 3 Liang Y. and Tedder T.F. (Genomics 2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PubMed id 11245982)1, 3 Ishibashi K.... Imai M. (Gene 2001)
  4. Identification of the novel differentiation marker MS4A8B and its murine homolog MS4A8A in colonic epithelial cells lost during neoplastic transformation in human colon. (PubMed id 23348583)1 Michel J....Schmieder A. (amp 2013)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PubMed id 11486273)1 Liang Y.... Tedder T.F. (Immunogenetics 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83661 HGNC: 13380 AceView: MS4A8B Ensembl:ENSG00000166959 euGenes: HUgn83661
ECgene: MS4A8 H-InvDB: MS4A8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MS4A8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MS4A8 gene:
Search GeneIP for patents involving MS4A8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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