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Aliases for MS4A7 Gene

Aliases for MS4A7 Gene

  • Membrane Spanning 4-Domains A7 2 3 5
  • Four-Span Transmembrane Protein 2 3 4
  • CD20 Antigen-Like 4 3 4
  • 4SPAN2 3 4
  • CD20L4 3 4
  • CFFM4 3 4
  • High Affinity Immunoglobulin Epsilon Receptor Beta Subunit 3
  • Membrane-Spanning 4-Domains, Subfamily A, Member 7 2
  • Membrane-Spanning 4-Domains Subfamily A Member 7 3
  • CD20/Fc-Epsilon-RI-Beta Family Member 4 3
  • CD20/FC-Epsilon-RI-Beta Family Member 4 4
  • MS4A8 3

External Ids for MS4A7 Gene

Previous GeneCards Identifiers for MS4A7 Gene

  • GC11P062539
  • GC11P061659
  • GC11P059921
  • GC11P059902
  • GC11P060145
  • GC11P056492

Summaries for MS4A7 Gene

Entrez Gene Summary for MS4A7 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A7 Gene

MS4A7 (Membrane Spanning 4-Domains A7) is a Protein Coding gene. An important paralog of this gene is MS4A6A.

UniProtKB/Swiss-Prot for MS4A7 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Gene Wiki entry for MS4A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A7 Gene

Genomics for MS4A7 Gene

Regulatory Elements for MS4A7 Gene

Enhancers for MS4A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F060362 1.4 FANTOM5 Ensembl ENCODE 19.1 -14.3 -14282 3.2 PKNOX1 RAD21 CHAMP1 ZNF143 THAP11 ZNF654 ZBTB11 ZEB2 REST ZNF589 MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A GC11P060374
GH11F060366 1.4 FANTOM5 Ensembl ENCODE 16.1 -11.0 -11004 1.7 MAZ TBL1XR1 MTA2 BHLHE40 EBF1 TBX21 EP300 RELA CBX5 ZNF585B MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
GH11F060454 0.9 ENCODE 11.5 +79.0 79048 6.7 TBP PKNOX1 TBL1XR1 WRNIP1 YBX1 BMI1 EGR1 ZNF143 ZNF207 ETV6 MS4A14 MS4A5 MS4A7 MS4A1 MS4A12
GH11F060486 0.8 ENCODE 10.3 +107.6 107631 0.2 CTCF MXI1 PKNOX1 TBL1XR1 WRNIP1 ZNF384 RAD21 RELA RFX5 ZNF143 MS4A1 MS4A13 MS4A6E MS4A14 MS4A7 MS4A18 MS4A12
GH11F060834 1.1 FANTOM5 Ensembl ENCODE 5.8 +457.1 457062 2.2 HLF JUN ETV6 PTGDR2 CCDC86 MS4A7 VPS37C LOC105369322 ENSG00000255845
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MS4A7 on UCSC Golden Path with GeneCards custom track

Promoters for MS4A7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000562989 1218 2601 CTCF TBP PKNOX1 EBF1 ZBTB40 ZNF316 EGR1 CBX5 POLR2A EED

Genomic Location for MS4A7 Gene

60,378,482 bp from pter
60,395,954 bp from pter
17,473 bases
Plus strand

Genomic View for MS4A7 Gene

Genes around MS4A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A7 Gene

Proteins for MS4A7 Gene

  • Protein details for MS4A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 7
    Protein Accession:
    Secondary Accessions:
    • A6NP53
    • Q6IAG8

    Protein attributes for MS4A7 Gene

    240 amino acids
    Molecular mass:
    26131 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A7 Gene


neXtProt entry for MS4A7 Gene

Post-translational modifications for MS4A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for MS4A7
  • Santa Cruz Biotechnology (SCBT) Antibodies for MS4A7

No data available for DME Specific Peptides for MS4A7 Gene

Domains & Families for MS4A7 Gene

Gene Families for MS4A7 Gene

Protein Domains for MS4A7 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A7: view

Function for MS4A7 Gene

Molecular function for MS4A7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A7: view

Animal Model Products

miRNA for MS4A7 Gene

miRTarBase miRNAs that target MS4A7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A7 Gene

Localization for MS4A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A7 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A7: view

Pathways & Interactions for MS4A7 Gene

SuperPathways for MS4A7 Gene

No Data Available

Interacting Proteins for MS4A7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000300184 Q9GZW8-MS4A7_HUMAN for MS4A7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MS4A7 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A7 Gene

Transcripts for MS4A7 Gene

Unigene Clusters for MS4A7 Gene

Membrane-spanning 4-domains, subfamily A, member 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: -

Relevant External Links for MS4A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MS4A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A7 Gene

This gene is overexpressed in Spleen (x13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MS4A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A7 Gene:


SOURCE GeneReport for Unigene cluster for MS4A7 Gene:


mRNA Expression by UniProt/SwissProt for MS4A7 Gene:

Tissue specificity: Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes.
genes like me logo Genes that share expression patterns with MS4A7: view

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for MS4A7 Gene

Orthologs for MS4A7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A7 34 35
  • 99.17 (n)
(Bos Taurus)
Mammalia MS4A7 34 35
  • 81.39 (n)
(Canis familiaris)
Mammalia MS4A7 34 35
  • 80.56 (n)
(Rattus norvegicus)
Mammalia Ms4a7 34
  • 71.58 (n)
(Mus musculus)
Mammalia Ms4a7 34 16 35
  • 70.71 (n)
Species where no ortholog for MS4A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A7 Gene

Gene Tree for MS4A7 (if available)
Gene Tree for MS4A7 (if available)

Paralogs for MS4A7 Gene

Paralogs for MS4A7 Gene

(2) SIMAP similar genes for MS4A7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MS4A7: view

Variants for MS4A7 Gene

Sequence variations from dbSNP and Humsavar for MS4A7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1062167 -- 60,394,054(+) AGTCA(A/G)TAAAT upstream-variant-2KB, utr-variant-3-prime
rs10736704 -- 60,376,903(+) AGGGG(A/G)TGGGA upstream-variant-2KB
rs10750936 -- 60,376,707(+) GGTGG(A/G)GATGG upstream-variant-2KB
rs11123 -- 60,392,731(-) CAGCT(A/T)ATAAG reference, stop-gained
rs111426694 -- 60,392,861(+) AAAGT(A/G)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A7 Gene

Variant ID Type Subtype PubMed ID
esv2744569 CNV deletion 23290073

Variation tolerance for MS4A7 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 55.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A7 Gene

Disorders for MS4A7 Gene

Relevant External Links for MS4A7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A7 Gene

Publications for MS4A7 Gene

  1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K. … Imai M. (Gene 2001) 2 3 4 64
  2. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3 4 64
  3. CFFM4: a new member of the CD20/Fc-epsilon-RI-beta-family. (PMID: 11685457) Gingras M.-C. … Margolin J.F. (Immunogenetics 2001) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for MS4A7 Gene

Sources for MS4A7 Gene

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