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Aliases for MS4A6E Gene

Aliases for MS4A6E Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 6E 2 3

External Ids for MS4A6E Gene

Previous GeneCards Identifiers for MS4A6E Gene

  • GC11P062496
  • GC11P061615
  • GC11P059877
  • GC11P059858
  • GC11P060102
  • GC11P056449

Summaries for MS4A6E Gene

Entrez Gene Summary for MS4A6E Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A6E Gene

MS4A6E (Membrane-Spanning 4-Domains, Subfamily A, Member 6E) is a Protein Coding gene. An important paralog of this gene is MS4A7.

UniProtKB/Swiss-Prot for MS4A6E Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A6E Gene

Genomics for MS4A6E Gene

Regulatory Elements for MS4A6E Gene

Genomic Location for MS4A6E Gene

60,334,831 bp from pter
60,396,596 bp from pter
61,766 bases
Plus strand

Genomic View for MS4A6E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A6E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A6E Gene

Proteins for MS4A6E Gene

  • Protein details for MS4A6E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 6E
    Protein Accession:
    Secondary Accessions:
    • Q3MIL2
    • Q8NE56
    • Q96PG4
    • Q96PG5

    Protein attributes for MS4A6E Gene

    147 amino acids
    Molecular mass:
    15909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A6E Gene

Proteomics data for MS4A6E Gene at MOPED

Post-translational modifications for MS4A6E Gene

No Post-translational modifications

Other Protein References for MS4A6E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MS4A6E Gene

Domains for MS4A6E Gene

Gene Families for MS4A6E Gene

Protein Domains for MS4A6E Gene


Suggested Antigen Peptide Sequences for MS4A6E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A6E: view

Function for MS4A6E Gene

Molecular function for MS4A6E Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex

Phenotypes for MS4A6E Gene

genes like me logo Genes that share phenotypes with MS4A6E: view

Animal Model Products

CRISPR Products

miRNA for MS4A6E Gene

miRTarBase miRNAs that target MS4A6E

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A6E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A6E Gene

Localization for MS4A6E Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A6E Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MS4A6E Gene COMPARTMENTS Subcellular localization image for MS4A6E gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A6E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A6E: view

Pathways for MS4A6E Gene

SuperPathways for MS4A6E Gene

No Data Available

Interacting Proteins for MS4A6E Gene

Gene Ontology (GO) - Biological Process for MS4A6E Gene


No data available for Pathways by source for MS4A6E Gene

Transcripts for MS4A6E Gene

mRNA/cDNA for MS4A6E Gene

Unigene Clusters for MS4A6E Gene

Membrane-spanning 4-domains, subfamily A, member 6E:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A6E

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A6E Gene

No ASD Table

Relevant External Links for MS4A6E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A6E Gene

mRNA expression in normal human tissues for MS4A6E Gene

mRNA differential expression in normal tissues according to GTEx for MS4A6E Gene

This gene is overexpressed in Testis (43.4).

SOURCE GeneReport for Unigene cluster for MS4A6E Gene Hs.662211

mRNA Expression by UniProt/SwissProt for MS4A6E Gene

Tissue specificity: Expressed by malignant and fetal tissue at very low levels
genes like me logo Genes that share expressions with MS4A6E: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for MS4A6E Gene

Orthologs for MS4A6E Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A6E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A6E 35
  • 99.09 (n)
  • 97.28 (a)
MS4A6E 36
  • 96 (a)
(Canis familiaris)
Mammalia -- 36
  • 33 (a)
(Mus musculus)
Mammalia Gm10212 36
  • 20 (a)
Ms4a6b 36
  • 27 (a)
Ms4a6c 36
  • 29 (a)
Ms4a6d 36
  • 31 (a)
Species with no ortholog for MS4A6E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A6E Gene

Gene Tree for MS4A6E (if available)
Gene Tree for MS4A6E (if available)

Paralogs for MS4A6E Gene

Paralogs for MS4A6E Gene

(2) SIMAP similar genes for MS4A6E Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MS4A6E: view

Variants for MS4A6E Gene

Sequence variations from dbSNP and Humsavar for MS4A6E Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10750935 -- 60,333,980(+) CCTCT(C/T)TCACC upstream-variant-2KB
rs10792265 -- 60,333,146(+) TAGTT(A/G)CCAGG upstream-variant-2KB
rs10792266 -- 60,333,930(+) AAGAC(A/G)CATCA upstream-variant-2KB
rs10792267 -- 60,334,245(+) GTTAC(A/G)GGCTC upstream-variant-2KB
rs10792268 -- 60,335,158(+) GAGGG(A/G)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A6E Gene

Variant ID Type Subtype PubMed ID
esv2744569 CNV Deletion 23290073

Relevant External Links for MS4A6E Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A6E Gene

Disorders for MS4A6E Gene

Relevant External Links for MS4A6E

Genetic Association Database (GAD)

No disorders were found for MS4A6E Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MS4A6E Gene

Publications for MS4A6E Gene

  1. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (PMID: 21460841) Naj A.C. … Schellenberg G.D. (Nat. Genet. 2011) 3
  5. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J. … AkyA1z L. (PLoS ONE 2013) 3

Products for MS4A6E Gene

Sources for MS4A6E Gene

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