MS4A6E Gene
protein-coding GIFtS: 43
GCID: GC11P060102
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membrane-spanning 4-domains, subfamily A, member 6E
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Aliases
for MS4A6E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Membrane-Spanning 4-Domains, Subfamily A, Member 6E1 2 | | Membrane-Spanning 4-Domains Subfamily A Member 6E2 |
Export aliases for MS4A6E gene to outside databasesPrevious GC identifers: GC11P062496 GC11P061615 GC11P060353 GC11P059877 GC11P059858 GC11P056449 |
Summaries
for MS4A6E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MS4A6E:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family arecharacterized by common structural features and similar intron/exon splice boundaries and display unique expressionpatterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3,among a cluster of family members. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: M4A6E_HUMAN, Q96DS6Function: May be involved in signal transduction as a component of a multimeric receptor complex
|
Genomic Views
for MS4A6E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MS4A6E gene promoter:
POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Cdc5 POU3F2 Evi-1 S8 FOXO1a En-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MS4A6E
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A6E |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12MS4A6E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P060102: view genomic region
(about GC identifiers)
Start:
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60,102,304 bp from pter |
End:
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60,164,069 bp from pter |
Size:
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61,766 bases |
Orientation:
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plus strand |
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Proteins
for MS4A6E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M4A6E_HUMAN, Q96DS6 (See
protein sequence)Recommended Name: Membrane-spanning 4-domains subfamily A member 6E Size: 147 amino acids; 15909 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q3MIL2 Q8NE56 Q96PG4 Q96PG5Explore the universe of human proteins at neXtProt for MS4A6E: NX_Q96DS6
MS4A6E Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_640342.1
ENSEMBL proteins: ENSP00000300182 ENSP00000432963 ENSP00000436675
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
MS4A6E for ontologies About GeneDecksing
MS4A6E Antibody Products:
Assay Products for MS4A6E: |
Protein
Domains /
Families
for MS4A6E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MS4A6E for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96DS6ProtoNet protein and cluster: Q96DS6 UniProtKB/Swiss-Prot: M4A6E_HUMAN, Q96DS6Similarity: Belongs to the MS4A family |
Function
for MS4A6E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: M4A6E_HUMAN, Q96DS6Function: May be involved in signal transduction as a component of a multimeric receptor complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A6E
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A6E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A6E |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
MS4A6E for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MS4A6E:
|
Pathways & Interactions
for MS4A6E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MS4A6E
|
Drugs & Compounds
for MS4A6E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MS4A6E
Search CenterWatch for drugs/clinical trials and news about MS4A6E / M4A6E
|
Transcripts
for MS4A6E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MS4A6E gene: NM_139249.2 Unigene Cluster for MS4A6E: Membrane-spanning 4-domains, subfamily A, member 6E Hs.662211 [show with all ESTs]Unigene Representative Sequence: FY2130223 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000300182(uc001npd.3) ENST00000532756 ENST00000530509
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A6E
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A6E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MS4A6E (NM_139249) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MS4A6E | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A6E |
Additional cDNA sequence: AF333758.1 AF354931.1 AF354932.1 AF354933.1 BC034588.1 BC069322.1 BC101783.1 1 DOTS entry: DT.100028273 24/30 AceView cDNA sequences (see all 30): AI806247 AI684553 AI699419 AA677863 BC069322 NM_139249 AI962642 BC034588 BU852484 AW072561 AA883638 AA909515 AF354933 AF354932 AF354931 AI222355 AI279944 AW951636 BX094573 AF333758 AA382998 BG718110 AI743473 BU854314
GeneLoc Exon Structure
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Expression
for MS4A6E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MS4A6E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCTGGATA
About this image
See MS4A6E Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MS4A6E
SOURCE GeneReport for Unigene cluster: Hs.662211
UniProtKB/Swiss-Prot: M4A6E_HUMAN, Q96DS6Tissue specificity: Expressed by malignant and fetal tissue at very low levels
SABiosciences Custom PCR Arrays for MS4A6E
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MS4A6E
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MS4A6E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A6E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A6E | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A6E |
Orthologs
for MS4A6E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for MS4A6E (if available)
TreeFam Gene Tree for MS4A6E (if available) |
Paralogs
for MS4A6E gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MS4A6E gene
- MS4A72 MS4A6A2
2 SIMAP similar genes for MS4A6E using alignment to 3 protein entries: M4A6E_HUMAN (see all proteins):MS4A6A MS4A7
MS4A6E for paralogs About GeneDecksing
|
Genomic Variants
for MS4A6E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MS4A6E (60102304 - 60164069 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MS4A6E: --
Human Gene Mutation Database (HGMD): MS4A6E
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MS4A6E |
|
Disorders
/ Diseases
for MS4A6E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MS4A6E for disorders About GeneDecksing
OMIM gene information: 608402
OMIM disorders: --
1  disease for MS4A6E: About MalaCardsalzheimer's disease
Export disorders for MS4A6E gene to outside databases
|
Publications
for MS4A6E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MS4A6E gene integrated from 9 sources:
(articles sorted by number of sources associating them with MS4A6E) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural organization of the human MS4A gene cluster on chromosome 11q12. (PubMed id 11486273)1, 2, 3, 9 Liang Y.... Tedder T.F. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA 1 are associated with late-onset Alzheimer's disease. (PubMed id 21460841)1 Naj A.C....Schellenberg G.D. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MS4A6E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MS4A6E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MS4A6E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MS4A6E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MS4A6E | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MS4A6E gene:
Search GeneIP for patents involving MS4A6E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MS4A6E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MS4A6E | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MS4A6E | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MS4A6E | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MS4A6E | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A6E | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A6E | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | MS4A6E Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A6E |
|  |  |  | | | | Search ThermoFisher Antibodies for MS4A6E |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A6E |
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