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MS4A6A Gene

protein-coding   GIFtS: 50
GCID: GC11M059939

Membrane-Spanning 4-Domains, Subfamily A, Member 6A


(Previous symbol: MS4A6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 6A1 2     MS4A6A-polymorph2
MS4A61 2 3 5     MST0902
Four-Span Transmembrane Protein 32 3     MSTP0902
4SPAN32 3     CD20-Like Precusor2
CD20L32 3     Four-Span Transmembrane Protein 3.12
CD20 Antigen-Like 32 3     Four-Span Transmembrane Protein 3.22
4SPAN3.22     Membrane-Spanning 4-Domains Subfamily A Member 6A2
HAIRB-iso2     

External Ids:    HGNC: 133751   Entrez Gene: 642312   Ensembl: ENSG000001100777   OMIM: 6065485   UniProtKB: Q9H2W13   
ORGUL members:         

Export aliases for MS4A6A gene to outside databases

Previous GC identifers: GC11M062333 GC11M061452 GC11M060189 GC11M059714 GC11M059695 GC11M059464 GC11M056287


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MS4A6A Gene:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are
characterized by common structural features and similar intron/exon splice boundaries and display unique
expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is
localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several
transcript variants that encode different protein isoforms. (provided by RefSeq, Oct 2011)

GeneCards Summary for MS4A6A Gene:
MS4A6A (membrane-spanning 4-domains, subfamily A, member 6A) is a protein-coding gene. Diseases associated with MS4A6A include esophagitis, and hepatitis b. An important paralog of this gene is MS4A6E.

UniProtKB/Swiss-Prot: M4A6A_HUMAN, Q9H2W1
Function: May be involved in signal transduction as a component of a multimeric receptor complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MS4A6A gene promoter:
         SREBP-1c   Brachyury   MyoD   Tal-1beta   Cdc5   SREBP-1b   c-Ets-1   SREBP-1a   Pax-4a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A6A promoter sequence
   Search Chromatin IP Primers for MS4A6A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MS4A6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.1

MS4A6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A6A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M059939:  view genomic region     (about GC identifiers)

Start:
59,939,080 bp from pter      End:
59,952,139 bp from pter
Size:
13,060 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M4A6A_HUMAN, Q9H2W1 (See protein sequence)
Recommended Name: Membrane-spanning 4-domains subfamily A member 6A  
Size: 248 amino acids; 26943 Da
Sequence caution: Sequence=AAG44626.1; Type=Frameshift; Positions=115; Sequence=AAG44672.1; Type=Frameshift;
Positions=68, 103;
Secondary accessions: A8K755 Q7Z4E8 Q8TBV7 Q8TEZ4 Q8TEZ5 Q96PG6 Q9H2L1 Q9H2N3 Q9H3V1 Q9HC76
Alternative splicing: 4 isoforms:  Q9H2W1-1   Q9H2W1-2   Q9H2W1-3   Q9H2W1-4   

Explore the universe of human proteins at neXtProt for MS4A6A: NX_Q9H2W1

Explore proteomics data for MS4A6A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MS4A6A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001234928.1  NP_071744.2  NP_690590.1  NP_690591.1  

    ENSEMBL proteins: 
     ENSP00000431901   ENSP00000392921   ENSP00000436979   ENSP00000436133   ENSP00000435844  
     ENSP00000403212   ENSP00000436172   ENSP00000435630   ENSP00000431266   ENSP00000433436  
     ENSP00000433012   ENSP00000437152   ENSP00000315878   ENSP00000392770  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry Q9H2W1

    ProtoNet protein and cluster: Q9H2W1

    UniProtKB/Swiss-Prot: M4A6A_HUMAN, Q9H2W1
    Similarity: Belongs to the MS4A family


    MS4A6A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4A6A_HUMAN, Q9H2W1
    Function: May be involved in signal transduction as a component of a multimeric receptor complex

    Phenotypes:
         2 GenomeRNAi human phenotypes for MS4A6A:

     Decreased Wnt reporter activit  Proliferating cells 

         1 MGI phenotypic allele for Ms4a6d (no phenotypes)

    MS4A6A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ms4a6dtm1Lex for MS4A6A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MS4A6A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MS4A6A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MS4A6A

    miRNA
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    Block miRNA regulation of human, mouse, rat MS4A6A using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MS4A6A:
    hsa-miR-590-3p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidMS4A6A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MS4A6A
    Predesigned siRNA for gene silencing in human, mouse, rat MS4A6A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): MS4A6A (NM_152852)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MS4A6A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A6A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M4A6A_HUMAN, Q9H2W1: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    MS4A6A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MS4A6A
    Interactions:

        Search GeneGlobe Interaction Network for MS4A6A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MS4A6A (M4A6A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MS4A6A gene (4 alternative transcripts): 
    NM_001247999.1  NM_022349.3  NM_152851.2  NM_152852.2  

    Unigene Cluster for MS4A6A:

    Membrane-spanning 4-domains, subfamily A, member 6A
    Hs.523702  [show with all ESTs]
    Unigene Representative Sequence: BC108728
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000528851(uc001not.3 uc010rlb.2) ENST00000420732 ENST00000530839
    ENST00000533989 ENST00000531914 ENST00000529054 ENST00000412309(uc010rla.2)
    ENST00000533023 ENST00000527254 ENST00000529906 ENST00000525549 ENST00000530179
    ENST00000526677 ENST00000532169 ENST00000534596 ENST00000533660 ENST00000531531
    ENST00000533409
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate MS4A6A:
    hsa-miR-590-3p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidMS4A6A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MS4A6A
    Predesigned siRNA for gene silencing in human, mouse, rat MS4A6A
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    GenScript: all cDNA clones in your preferred vector (see all 3): MS4A6A (NM_152852)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A6A
    Primer
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    OriGene qPCR primer pairs and template standards for MS4A6A
    OriGene qSTAR qPCR primer pairs in human, mouse for MS4A6A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MS4A6A
      QuantiTect SYBR Green Assays in human, mouse, rat MS4A6A
      QuantiFast Probe-based Assays in human, mouse, rat MS4A6A

    Additional mRNA sequence: 

    AB013104.1 AF142409.1 AF172819.1 AF212240.1 AF237908.1 AF253977.1 AF261136.1 AF286866.1 
    AF350502.1 AF350503.1 AF354930.1 AK291870.1 AK300725.1 AK301387.1 BC022854.1 BC108728.1 

    15 DOTS entries:

    DT.444503  DT.91751260  DT.95275355  DT.120703088  DT.40198787  DT.91724476  DT.95275356  DT.100826512 
    DT.120703099  DT.91751252  DT.91751254  DT.95275359  DT.75174169  DT.91751268  DT.95331750 

    Selected AceView cDNA sequences (see all 303):

    CR609705 AA736644 AI373386 AA441988 AA713812 AI239461 NM_152852 AI733416 
    CD107162 CB157025 CR625448 AI375656 CA436521 AI800594 AI361585 AV717594 
    BI821317 CR606472 R58859 AI091306 CB155905 AA045294 AA411404 AA449402 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MS4A6A (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b
    SP1:                                                        -                 -                                         -               
    SP2:                                                        -                 -                                                         
    SP3:                                                        -                 -     -                                                   
    SP4:        -     -     -     -     -                 -     -                 -                                                         
    SP5:                                                                                                  -                 -               


    ECgene alternative splicing isoforms for MS4A6A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MS4A6A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTAGGATA
    MS4A6A Expression
    About this image


    MS4A6A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    MS4A6A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MS4A6A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523702

    UniProtKB/Swiss-Prot: M4A6A_HUMAN, Q9H2W1
    Tissue specificity: Variable expression in some B-cell, myelomonocytic, and erythroleukemia cell lines

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A6A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MS4A6A gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ms4a6d1 , 5 membrane-spanning 4-domains, subfamily A, member 6D1, 5 66.94(n)1
    52.63(a)1
      19 (8.45 cM)5
    687741  NM_026835.21  NP_081111.11 
     115866045 


    ENSEMBL Gene Tree for MS4A6A (if available)
    TreeFam Gene Tree for MS4A6A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MS4A6A gene
    MS4A6E2  MS4A72  
    3 SIMAP similar genes for MS4A6A using alignment to 11 protein entries:     M4A6A_HUMAN (see all proteins):
    MS4A6E    MS4A12    MS4A7

    MS4A6A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MS4A6A
    PGOHUM00000243553


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MS4A6A (see all 366)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161425101,2
    C,F--59860138(+) TTTTTT/AAATGT 2 -- int11Minor allele frequency- A:0.05WA 118
    rs1444726371,2
    F--59860283(+) CATATC/TCACAG 2 -- int11Minor allele frequency- T:0.00NA 4530
    rs1401309481,2
    C,F--59860354(+) ACACTC/GTAGAA 2 -- int11Minor allele frequency- G:0.00NA 4526
    rs1503942141,2
    C--59860371(+) AATAT-/GTTAG 
     GTCTTCA
    GTTAG
    2 -- cds10--------
    rs1813010431,2
    C--59860392(+) TTCAAC/TCAGGT 2 -- int10--------
    rs3705517861,2
    C--59860396(+) ATCAGG/TTTCAA 2 -- int10--------
    rs5979821,2
    C,A,H--59860581(-) CTTATT/GGCTTT 2 -- int112Minor allele frequency- G:0.16NA WA CSA EA 377
    rs1869648481,2
    --59860589(+) AAGTCC/TATAGG 2 -- int10--------
    rs1907545431,2
    C--59860641(+) GCAAAC/TGAATT 2 -- ut310--------
    rs116052521,2
    C,F,H--59860700(+) AGTTAC/TGTGTG 2 -- ut315Minor allele frequency- T:0.01NS EA NA 424

    HapMap Linkage Disequilibrium report for MS4A6A (59939080 - 59952139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MS4A6A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674897CNV Deletion23128226
    esv2744568CNV Deletion23290073
    esv33843CNV Loss17666407
    nsv524137CNV Loss19592680
    nsv468579CNV Gain19166990
    nsv832174CNV Gain17160897
    nsv832173CNV Gain17160897

    Human Gene Mutation Database (HGMD): MS4A6A
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606548    OMIM disorders: --

    6 diseases for MS4A6A:    
    About MalaCards
    esophagitis    hepatitis b    alzheimer's disease    adenocarcinoma
    hepatitis    retinitis


    MS4A6A for disorders           About GeneDecksing

    Genetic Association Database (GAD): MS4A6A
    Human Genome Epidemiology (HuGE) Navigator: MS4A6A (2 documents)

    Export disorders for MS4A6A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MS4A6A gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with MS4A6A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PubMed id 11245982)1, 2, 3 Ishibashi K.... Imai M. (Gene 2001)
    2. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PubMed id 11401424)1, 2, 3 Liang Y. and Tedder T.F. (Genomics 2001)
    3. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PubMed id 11486273)1, 2, 9 Liang Y.... Tedder T.F. (Immunogenetics 2001)
    4. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. (PubMed id 21460840)1, 4 Hollingworth P....Williams J. (Nat. Genet. 2011)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. (PubMed id 23969696)1 Sabater-Lleal M....O'Donnell C.J. (Circulation 2013)
    8. The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease. (PubMed id 22382309)1 Deng Y.L....Chen S.D. (Hum. Genet. 2012)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64231 HGNC: 13375 AceView: MS4A6A Ensembl:ENSG00000110077 euGenes: HUgn64231
    ECgene: MS4A6A H-InvDB: MS4A6A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MS4A6A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MS4A6A gene:
    Search GeneIP for patents involving MS4A6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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