MS4A5 Gene
protein-coding GIFtS: 46
GCID: GC11P060197
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|
membrane-spanning 4-domains, subfamily A, member 5
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Aliases
for MS4A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Membrane-Spanning 4-Domains, Subfamily A, Member 51 2 | | CD20 Antigen-Like 22 3 | | CD20L21 2 3 5 | | CD20-L22 | | TETM42 3 5 | | Membrane-Spanning 4-Domains Subfamily A Member 52 | | Testis-Expressed Transmembrane Protein 42 3 | | Testis-Expressed Transmembrane-4 Protein2 |
Export aliases for MS4A5 gene to outside databasesPrevious GC identifers: GC11P062590 GC11P061710 GC11P060447 GC11P059972 GC11P059953 GC11P056544 |
Summaries
for MS4A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MS4A5:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family arecharacterized by common structural features and similar intron/exon splice boundaries and display unique expressionpatterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cellsspecifically, it may be involved in signal transduction like many of its related family members. The gene encodingthis protein is localized to 11q12, among a cluster of family members. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MS4A5_HUMAN, Q9H3V2Function: May be involved in signal transduction as a component of a multimeric receptor complex
|
Genomic Views
for MS4A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MS4A5 gene promoter:
Sox5 AML1a Olf-1 GATA-2 Meis-1b Evi-1 POU2F1 POU2F1a Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MS4A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12MS4A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P060197: view genomic region
(about GC identifiers)
Start:
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60,197,062 bp from pter |
End:
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60,222,687 bp from pter |
Size:
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25,626 bases |
Orientation:
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plus strand |
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Proteins
for MS4A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MS4A5_HUMAN, Q9H3V2 (See
protein sequence)Recommended Name: Membrane-spanning 4-domains subfamily A member 5 Size: 200 amino acids; 22283 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9BZH1Explore the universe of human proteins at neXtProt for MS4A5: NX_Q9H3V2
MS4A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076434.2
ENSEMBL proteins: ENSP00000300190 ENSP00000435330 ENSP00000435192 ENSP00000433802 ENSP00000432836
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
MS4A5 for ontologies About GeneDecksing
MS4A5 Antibody Products:
Assay Products for MS4A5: |
Protein
Domains /
Families
for MS4A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MS4A5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H3V2ProtoNet protein and cluster: Q9H3V2 UniProtKB/Swiss-Prot: MS4A5_HUMAN, Q9H3V2Similarity: Belongs to the MS4A family |
Function
for MS4A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MS4A5_HUMAN, Q9H3V2Function: May be involved in signal transduction as a component of a multimeric receptor complex
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A5
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
MS4A5 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MS4A5:
Animal Models:
Mouse knock-out Ms4a5tm1Lex for MS4A5
1 MGI phenotypic allele  for Ms4a5 (no phenotypes)
MS4A5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MS4A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MS4A5
1 Interacting protein for MS4A5 (Q9H3V23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MS4A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MS4A5
Search CenterWatch for drugs/clinical trials and news about MS4A5
|
Transcripts
for MS4A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MS4A5 gene: NM_023945.2 Unigene Cluster for MS4A5: Membrane-spanning 4-domains, subfamily A, member 5 Hs.178066 [show with all ESTs]Unigene Representative Sequence: BU1601836 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000300190(uc001npo.3) ENST00000533885 ENST00000534071 ENST00000531403
ENST00000528905 ENST00000528093
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MS4A5 (NM_023945) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MS4A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A5 |
Additional cDNA sequence: AB013103.1 AF237907.1 AF321127.1 BC029884.1 3 DOTS entries: DT.454916 DT.210380 DT.95285765 24/146 AceView cDNA sequences (see all 146): AI253701 BM791084 AI568297 AI864701 AA505051 NM_023945 BI829760 AA416972 AI520832 AA287127 AA731893 X07204 BC029884 BM909362 CR617832 BQ006410 NM_152866 AA287489 AA411806 AA781801 AA814100 AI080700 AI568384 NM_152867
GeneLoc Exon Structure
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Expression
for MS4A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MS4A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTCAAGCA
About this image
See MS4A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MS4A5
SOURCE GeneReport for Unigene cluster: Hs.178066
UniProtKB/Swiss-Prot: MS4A5_HUMAN, Q9H3V2Tissue specificity: Expressed at high level in the testis. Detected also in the pancreas, heart and in the brain
SABiosciences Custom PCR Arrays for MS4A5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MS4A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MS4A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A5 |
Orthologs
for MS4A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MS4A5 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for MS4A5 (if available)
TreeFam Gene Tree for MS4A5 (if available) |
Paralogs
for MS4A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MS4A5 gene
- MS4A142
4 SIMAP similar genes for MS4A5 using alignment to 4 protein entries: MS4A5_HUMAN (see all proteins):MS4A14 MS4A1 MS4A4A MS4A8B
MS4A5 for paralogs About GeneDecksing
|
Genomic Variants
for MS4A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MS4A5 (60197062 - 60222687 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MS4A5
2 CNVs: 85809 75675 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MS4A5 |
|
Disorders
/ Diseases
for MS4A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MS4A5 for disorders About GeneDecksing
OMIM gene information: 606499
OMIM disorders: --
2  diseases for MS4A5: About MalaCardshepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: MS4A5 (1 document)
Export disorders for MS4A5 gene to outside databases
|
Publications
for MS4A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MS4A5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MS4A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PubMed id 11401424)1, 2, 3 Liang Y. and Tedder T.F. (2001)
- Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PubMed id 11245982)1, 2, 3 Ishibashi K.... Imai M. (2001)
- Isolation, tissue distribution, and chromosomal localization of a novel testis-specific human four-transmembrane gene related to CD20 and Fc-epsilon-RI-beta. (PubMed id 11162526)1, 2, 9 Hulett M.D.... Parish C.R. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structural organization of the human MS4A gene cluster on chromosome 11q12. (PubMed id 11486273)1, 9 Liang Y.... Tedder T.F. (2001)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MS4A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MS4A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MS4A5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MS4A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MS4A5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MS4A5 gene:
Search GeneIP for patents involving MS4A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MS4A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | MS4A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A5 |
|  |  |  | | | | Search ThermoFisher Antibodies for MS4A5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A5 |
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