Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MS4A5 Gene

Aliases for MS4A5 Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 5 2 3
  • CD20L2 3 4 6
  • TETM4 3 4 6
  • Testis-Expressed Transmembrane Protein 4 3 4
  • CD20 Antigen-Like 2 3 4
  • Membrane-Spanning 4-Domains Subfamily A Member 5 3
  • Testis-Expressed Transmembrane-4 Protein 3
  • CD20-L2 3

External Ids for MS4A5 Gene

Previous GeneCards Identifiers for MS4A5 Gene

  • GC11P062590
  • GC11P061710
  • GC11P059972
  • GC11P059953
  • GC11P060197
  • GC11P056544

Summaries for MS4A5 Gene

Entrez Gene Summary for MS4A5 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cells specifically, it may be involved in signal transduction like many of its related family members. The gene encoding this protein is localized to 11q12, among a cluster of family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A5 Gene

MS4A5 (Membrane-Spanning 4-Domains, Subfamily A, Member 5) is a Protein Coding gene. An important paralog of this gene is MS4A14.

UniProtKB/Swiss-Prot for MS4A5 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A5 Gene

Genomics for MS4A5 Gene

Regulatory Elements for MS4A5 Gene

Genomic Location for MS4A5 Gene

Start:
60,429,589 bp from pter
End:
60,455,214 bp from pter
Size:
25,626 bases
Orientation:
Plus strand

Genomic View for MS4A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A5 Gene

Proteins for MS4A5 Gene

  • Protein details for MS4A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3V2-MS4A5_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 5
    Protein Accession:
    Q9H3V2
    Secondary Accessions:
    • Q9BZH1

    Protein attributes for MS4A5 Gene

    Size:
    200 amino acids
    Molecular mass:
    22283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A5 Gene

Proteomics data for MS4A5 Gene at MOPED

Post-translational modifications for MS4A5 Gene

No Post-translational modifications

Other Protein References for MS4A5 Gene

No data available for DME Specific Peptides for MS4A5 Gene

Domains for MS4A5 Gene

Protein Domains for MS4A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MS4A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3V2

UniProtKB/Swiss-Prot:

MS4A5_HUMAN :
  • Q9H3V2
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A5: view

No data available for Gene Families for MS4A5 Gene

Function for MS4A5 Gene

Molecular function for MS4A5 Gene

UniProtKB/Swiss-Prot Function: May be involved in signal transduction as a component of a multimeric receptor complex

Phenotypes for MS4A5 Gene

genes like me logo Genes that share phenotypes with MS4A5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MS4A5 Gene

Localization for MS4A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A5 Gene COMPARTMENTS Subcellular localization image for MS4A5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A5: view

Pathways for MS4A5 Gene

SuperPathways for MS4A5 Gene

No Data Available

Interacting Proteins for MS4A5 Gene

Selected Interacting proteins: Q9H3V2-MS4A5_HUMAN for MS4A5 Gene via I2D

Symbol External ID(s) Details
CFTR

Gene Ontology (GO) - Biological Process for MS4A5 Gene

None

No data available for Pathways by source for MS4A5 Gene

Transcripts for MS4A5 Gene

mRNA/cDNA for MS4A5 Gene

Unigene Clusters for MS4A5 Gene

Membrane-spanning 4-domains, subfamily A, member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A5 Gene

No ASD Table

Relevant External Links for MS4A5 Gene

GeneLoc Exon Structure for
MS4A5
ECgene alternative splicing isoforms for
MS4A5

Expression for MS4A5 Gene

mRNA expression in normal human tissues for MS4A5 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A5 Gene

This gene is overexpressed in Testis (52.8).

SOURCE GeneReport for Unigene cluster for MS4A5 Gene Hs.178066

mRNA Expression by UniProt/SwissProt for MS4A5 Gene

Q9H3V2-MS4A5_HUMAN
Tissue specificity: Expressed at high level in the testis. Detected also in the pancreas, heart and in the brain
genes like me logo Genes that share expressions with MS4A5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for MS4A5 Gene

Orthologs for MS4A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A5 35
  • 99.33 (n)
  • 99 (a)
MS4A5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MS4A5 35
  • 77.1 (n)
  • 62.63 (a)
MS4A5 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MS4A5 35
  • 81.22 (n)
  • 67.01 (a)
mouse
(Mus musculus)
Mammalia Ms4a5 35
  • 77.04 (n)
  • 69.39 (a)
Ms4a5 16
Ms4a5 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MS4A5 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ms4a5 35
  • 77.1 (n)
  • 69.7 (a)
Species with no ortholog for MS4A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A5 Gene

ENSEMBL:
Gene Tree for MS4A5 (if available)
TreeFam:
Gene Tree for MS4A5 (if available)

Paralogs for MS4A5 Gene

Paralogs for MS4A5 Gene

Selected SIMAP similar genes for MS4A5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MS4A5: view

Variants for MS4A5 Gene

Sequence variations from dbSNP and Humsavar for MS4A5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs708229 -- 60,430,855(+) TTCAC(C/G/T)TTGTT reference, synonymous-codon
rs750791 -- 60,434,934(+) TACTA(C/T)GCTCT intron-variant
rs894589 -- 60,435,073(+) TGCAC(A/G)CCCCA intron-variant
rs894590 -- 60,435,274(+) GAGGC(A/C)TAAAA intron-variant
rs1443244 -- 60,444,404(+) CATGG(G/T)AGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A5 Gene

Variant ID Type Subtype PubMed ID
esv2744569 CNV Deletion 23290073
nsv508635 CNV Loss 20534489

Relevant External Links for MS4A5 Gene

HapMap Linkage Disequilibrium report
MS4A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A5 Gene

Disorders for MS4A5 Gene

Relevant External Links for MS4A5

Human Genome Epidemiology (HuGE) Navigator
MS4A5
genes like me logo Genes that share disorders with MS4A5: view

No data available for UniProtKB/Swiss-Prot for MS4A5 Gene

Publications for MS4A5 Gene

  1. Isolation, tissue distribution, and chromosomal localization of a novel testis-specific human four-transmembrane gene related to CD20 and Fc-epsilon-RI-beta. (PMID: 11162526) Hulett M.D. … Parish C.R. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K. … Imai M. (Gene 2001) 2 3 4
  3. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3 4
  4. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MS4A5 Gene

Sources for MS4A5 Gene

Back to Top

Content