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Aliases for MS4A5 Gene

Aliases for MS4A5 Gene

  • Membrane Spanning 4-Domains A5 2 3 5
  • Testis-Expressed Transmembrane Protein 4 3 4
  • CD20 Antigen-Like 2 3 4
  • CD20L2 3 4
  • TETM4 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 5 2
  • Membrane-Spanning 4-Domains Subfamily A Member 5 3
  • Testis-Expressed Transmembrane-4 Protein 3
  • CD20-L2 3

External Ids for MS4A5 Gene

Previous GeneCards Identifiers for MS4A5 Gene

  • GC11P062590
  • GC11P061710
  • GC11P059972
  • GC11P059953
  • GC11P060197
  • GC11P056544

Summaries for MS4A5 Gene

Entrez Gene Summary for MS4A5 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cells specifically, it may be involved in signal transduction like many of its related family members. The gene encoding this protein is localized to 11q12, among a cluster of family members. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A5 Gene

MS4A5 (Membrane Spanning 4-Domains A5) is a Protein Coding gene. An important paralog of this gene is MS4A14.

UniProtKB/Swiss-Prot for MS4A5 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A5 Gene

Genomics for MS4A5 Gene

Regulatory Elements for MS4A5 Gene

Enhancers for MS4A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F061330 0.6 ENCODE 16.2 +904.4 904355 6.0 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ENSG00000256733 ENSG00000255959 ENSG00000255845 LINC00301 SCGB1D1 EEF1DP8 MS4A5 MS4A13 LOC105369323 TMEM216
GH11F060731 0.5 FANTOM5 14.7 +302.6 302617 0.4 MS4A5 MS4A14 MS4A6E MS4A13 MS4A18 MS4A15
GH11F060388 0.9 Ensembl ENCODE 12.1 -40.0 -39959 2.3 TBP PKNOX1 MXI1 USF1 TBL1XR1 SIN3A MAX BMI1 CBX5 NFYB MS4A14 MS4A1 MS4A5 GC11M060363
GH11F060454 0.2 ENCODE 11.9 +27.9 27941 6.7 TBP PKNOX1 TBL1XR1 WRNIP1 YBX1 BMI1 EGR1 ZNF143 ZNF207 ETV6 MS4A14 MS4A5 MS4A7 MS4A1 MS4A12
GH11F060366 1.2 FANTOM5 Ensembl ENCODE 11.4 -62.1 -62111 1.7 MAZ TBL1XR1 MTA2 BHLHE40 EBF1 TBX21 EP300 RELA CBX5 ZNF585B MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MS4A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A5 Gene

60,429,589 bp from pter
60,455,214 bp from pter
25,626 bases
Plus strand

Genomic View for MS4A5 Gene

Genes around MS4A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A5 Gene

Proteins for MS4A5 Gene

  • Protein details for MS4A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 5
    Protein Accession:
    Secondary Accessions:
    • Q9BZH1

    Protein attributes for MS4A5 Gene

    200 amino acids
    Molecular mass:
    22283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A5 Gene

Post-translational modifications for MS4A5 Gene

No Post-translational modifications

Other Protein References for MS4A5 Gene

No data available for DME Specific Peptides for MS4A5 Gene

Domains & Families for MS4A5 Gene

Gene Families for MS4A5 Gene

Protein Domains for MS4A5 Gene


Suggested Antigen Peptide Sequences for MS4A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A5: view

Function for MS4A5 Gene

Molecular function for MS4A5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MS4A5

miRNA for MS4A5 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A5 Gene

Localization for MS4A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MS4A5 Gene COMPARTMENTS Subcellular localization image for MS4A5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A5: view

Pathways & Interactions for MS4A5 Gene

SuperPathways for MS4A5 Gene

No Data Available

Interacting Proteins for MS4A5 Gene

Selected Interacting proteins: Q9H3V2-MS4A5_HUMAN for MS4A5 Gene via IID

Gene Ontology (GO) - Biological Process for MS4A5 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A5 Gene

Transcripts for MS4A5 Gene

Unigene Clusters for MS4A5 Gene

Membrane-spanning 4-domains, subfamily A, member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A5 Gene

No ASD Table

Relevant External Links for MS4A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MS4A5 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A5 Gene

This gene is overexpressed in Testis (x52.8).

NURSA nuclear receptor signaling pathways regulating expression of MS4A5 Gene:


SOURCE GeneReport for Unigene cluster for MS4A5 Gene:


mRNA Expression by UniProt/SwissProt for MS4A5 Gene:

Tissue specificity: Expressed at high level in the testis. Detected also in the pancreas, heart and in the brain.
genes like me logo Genes that share expression patterns with MS4A5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MS4A5 Gene

Orthologs for MS4A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A5 34 35
  • 99.33 (n)
(Canis familiaris)
Mammalia MS4A5 34
  • 81.22 (n)
(Bos Taurus)
Mammalia MS4A5 34 35
  • 77.1 (n)
(Rattus norvegicus)
Mammalia Ms4a5 34
  • 77.1 (n)
(Mus musculus)
Mammalia Ms4a5 34 16 35
  • 77.04 (n)
(Monodelphis domestica)
Mammalia MS4A5 35
  • 43 (a)
Species where no ortholog for MS4A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A5 Gene

Gene Tree for MS4A5 (if available)
Gene Tree for MS4A5 (if available)

Paralogs for MS4A5 Gene

Paralogs for MS4A5 Gene

(4) SIMAP similar genes for MS4A5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MS4A5: view

Variants for MS4A5 Gene

Sequence variations from dbSNP and Humsavar for MS4A5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036402 A colorectal cancer sample
rs10716981 -- 60,432,022(+) ATGTT(-/C)CCATC intron-variant
rs10736705 -- 60,433,416(+) GCATT(C/T)AGTTA intron-variant
rs10897060 -- 60,430,270(+) AAAAA(A/C)AACCC intron-variant
rs10897061 -- 60,431,573(+) TGAGG(A/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A5 Gene

Variant ID Type Subtype PubMed ID
dgv51n111 CNV deletion 26073780
esv2744569 CNV deletion 23290073
nsv508635 CNV deletion 20534489

Variation tolerance for MS4A5 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A5 Gene

Disorders for MS4A5 Gene

Relevant External Links for MS4A5

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A5 Gene

Publications for MS4A5 Gene

  1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K. … Imai M. (Gene 2001) 2 3 4 64
  2. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3 4 64
  3. Isolation, tissue distribution, and chromosomal localization of a novel testis-specific human four-transmembrane gene related to CD20 and Fc-epsilon-RI-beta. (PMID: 11162526) Hulett M.D. … Parish C.R. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 3 22 64

Products for MS4A5 Gene

Sources for MS4A5 Gene

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