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Aliases for MS4A4E Gene

Aliases for MS4A4E Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 4E 2 3

External Ids for MS4A4E Gene

Previous GeneCards Identifiers for MS4A4E Gene

  • GC11U990623
  • GC11M059732
  • GC11M059969
  • GC11M056316

Summaries for MS4A4E Gene

Entrez Gene Summary for MS4A4E Gene

  • Most MS4A genes, including MS4A4E, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]

GeneCards Summary for MS4A4E Gene

MS4A4E (Membrane-Spanning 4-Domains, Subfamily A, Member 4E) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A4E Gene

Genomics for MS4A4E Gene

Regulatory Elements for MS4A4E Gene

Transcription factor binding sites by QIAGEN in the MS4A4E gene promoter:

Genomic Location for MS4A4E Gene

Start:
60,201,253 bp from pter
End:
60,243,102 bp from pter
Size:
41,850 bases
Orientation:
Minus strand

Genomic View for MS4A4E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A4E Gene

Proteins for MS4A4E Gene

  • Protein details for MS4A4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PG1-M4A4E_HUMAN
    Recommended name:
    Putative membrane-spanning 4-domains subfamily A member 4E
    Protein Accession:
    Q96PG1
    Secondary Accessions:
    • Q3C1W1
    • Q3C1W3
    • Q3C1W4

    Protein attributes for MS4A4E Gene

    Size:
    132 amino acids
    Molecular mass:
    15209 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL07363.1; Type=Miscellaneous discrepancy; Note=Intron retention. The entire sequence corresponds to part of an intron.; Evidence={ECO:0000305};

    Alternative splice isoforms for MS4A4E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MS4A4E Gene

Proteomics data for MS4A4E Gene at MOPED

Post-translational modifications for MS4A4E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MS4A4E Gene

Domains for MS4A4E Gene

Protein Domains for MS4A4E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MS4A4E Gene

Graphical View of Domain Structure for InterPro Entry

Q96PG1

UniProtKB/Swiss-Prot:

M4A4E_HUMAN :
  • Q96PG1
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A4E: view

No data available for Gene Families for MS4A4E Gene

Function for MS4A4E Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MS4A4E Gene

Localization for MS4A4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A4E Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A4E Gene COMPARTMENTS Subcellular localization image for MS4A4E gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MS4A4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A4E: view

Pathways for MS4A4E Gene

SuperPathways for MS4A4E Gene

No Data Available

Interacting Proteins for MS4A4E Gene

Gene Ontology (GO) - Biological Process for MS4A4E Gene

None

No data available for Pathways by source for MS4A4E Gene

Transcripts for MS4A4E Gene

mRNA/cDNA for MS4A4E Gene

(13) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A4E Gene

Membrane-spanning 4-domains, subfamily A, member 4E:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A4E

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A4E Gene

No ASD Table

Relevant External Links for MS4A4E Gene

GeneLoc Exon Structure for
MS4A4E
ECgene alternative splicing isoforms for
MS4A4E

Expression for MS4A4E Gene

mRNA expression in normal human tissues for MS4A4E Gene

mRNA differential expression in normal tissues according to GTEx for MS4A4E Gene

This gene is overexpressed in Spleen (5.8).

SOURCE GeneReport for Unigene cluster for MS4A4E Gene Hs.559934

genes like me logo Genes that share expressions with MS4A4E: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MS4A4E Gene

Orthologs for MS4A4E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MS4A4E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A4E 36
  • 97 (a)
OneToOne
Species with no ortholog for MS4A4E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A4E Gene

ENSEMBL:
Gene Tree for MS4A4E (if available)
TreeFam:
Gene Tree for MS4A4E (if available)

Paralogs for MS4A4E Gene

Selected SIMAP similar genes for MS4A4E Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MS4A4E: view

No data available for Paralogs for MS4A4E Gene

Variants for MS4A4E Gene

Sequence variations from dbSNP and Humsavar for MS4A4E Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs584469 -- 60,221,389(+) attcc(C/T)gccac intron-variant
rs585540 -- 60,232,605(-) CCTGT(A/G)AAGAC intron-variant
rs586127 -- 60,235,885(-) ATACC(C/G)TTCTA intron-variant
rs594414 -- 60,218,427(-) tatta(A/G)ggagt intron-variant
rs600550 -- 60,230,193(+) TATAA(C/T)AGTTG intron-variant

Relevant External Links for MS4A4E Gene

HapMap Linkage Disequilibrium report
MS4A4E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MS4A4E Gene

Disorders for MS4A4E Gene

Relevant External Links for MS4A4E

Genetic Association Database (GAD)
MS4A4E
Human Genome Epidemiology (HuGE) Navigator
MS4A4E
genes like me logo Genes that share disorders with MS4A4E: view

No data available for UniProtKB/Swiss-Prot for MS4A4E Gene

Publications for MS4A4E Gene

  1. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. (PMID: 21460840) Hollingworth P. … Williams J. (Nat. Genet. 2011) 3
  4. Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. (PMID: 23118302) Chu A.Y. … Ridker P.M. (Circ Cardiovasc Genet 2012) 3
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 48

Products for MS4A4E Gene

Sources for MS4A4E Gene

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