MS4A4E Gene
protein-coding GIFtS: 31
GCID: GC11M059969 (predicted)
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membrane-spanning 4-domains, subfamily A, member 4E
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Aliases
for MS4A4E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Membrane-Spanning 4-Domains, Subfamily A, Member 4E1 2 |
Export aliases for MS4A4E gene to outside databasesPrevious GC identifers: GC11U990623 GC11M059732 GC11M056316 |
Summaries
for MS4A4E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MS4A4E:
Most MS4A genes, including MS4A4E, encode proteins with at least 4 potential transmembrane domains and N- andC-terminal cytoplasmic domains encoded by distinct exons.(supplied by OMIM, Apr 2004)
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Genomic Views
for MS4A4E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NT_167190.1 NC_018922.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MS4A4E gene promoter:
MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MS4A4E
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A4E |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2MS4A4E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M059969: view genomic region
(about GC identifiers)
Start:
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59,968,726 bp from pter |
End:
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60,010,561 bp from pter |
Size:
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41,836 bases |
Orientation:
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minus strand |
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Proteins
for MS4A4E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: M4A4E_HUMAN, Q96PG1 (See
protein sequence)Recommended Name: Putative membrane-spanning 4-domains subfamily A member 4E Size: 132 amino acids; 15209 Da
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAL07363.1; Type=Miscellaneous discrepancy; Note=Intron retention. The entire sequencecorresponds to part of an intron;
Secondary accessions: Q3C1W1 Q3C1W3 Q3C1W4Alternative splicing: 3 isoforms: Q96PG1-1 Q96PG1-2 Q96PG1-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MS4A4E: NX_Q96PG1
MS4A4E Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000435345 ENSP00000436124 ENSP00000389556 ENSP00000435601 ENSP00000436446 ENSP00000415222 ENSP00000381956 ENSP00000381954
Human Recombinant Protein Products for MS4A4E:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
MS4A4E for ontologies About GeneDecksing
MS4A4E Antibody Products:
Assay Products for MS4A4E: |
Protein
Domains /
Families
for MS4A4E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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MS4A4E for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96PG1ProtoNet protein and cluster: Q96PG1 UniProtKB/Swiss-Prot: M4A4E_HUMAN, Q96PG1Similarity: Belongs to the MS4A family |
Function
for MS4A4E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004872 | receptor activity |
-- | -- |
MS4A4E for ontologies About GeneDecksing
Animal Models:
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Pathways & Interactions
for MS4A4E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MS4A4E
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Drugs & Compounds
for MS4A4E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MS4A4E
Search CenterWatch for drugs/clinical trials and news about MS4A4E / M4A4E 
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Transcripts
for MS4A4E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for MS4A4E: Membrane-spanning 4-domains, subfamily A, member 4E Hs.559934 Unigene Representative Sequence: AK3001028 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000532442 ENST00000526153(uc001now.2) ENST00000425663(uc001nox.2)
ENST00000526086(uc009ymw.2) ENST00000528394(uc001noy.2) ENST00000427611
ENST00000398986 ENST00000398984(uc001nov.2)
Additional cDNA sequence: AB231725.1 AB231726.1 AB231727.1 AB231728.1 AB231729.1 AB231730.1 AB231731.1 AK300102.1 XM_003119183.1 1 DOTS entry: DT.120678560
GeneLoc Exon Structure
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Expression
for MS4A4E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MS4A4E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAATAATAA
About this image
See MS4A4E Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.559934
SABiosciences Custom PCR Arrays for MS4A4E
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MS4A4E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A4E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A4E |
Orthologs
for MS4A4E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MS4A4E (if available)
TreeFam Gene Tree for MS4A4E (if available) |
Paralogs
for MS4A4E gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for MS4A4E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MS4A4E (59968726 - 60010561 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MS4A4E: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MS4A4E |
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Disorders
/ Diseases
for MS4A4E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MS4A4E for disorders About GeneDecksing
OMIM gene information: 608401
OMIM disorders: --
2  diseases for MS4A4E: About MalaCardstay-sachs disease alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: MS4A4E (1 document)
Export disorders for MS4A4E gene to outside databases
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Publications
for MS4A4E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MS4A4E gene integrated from 9 sources:
(articles sorted by number of sources associating them with MS4A4E) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural organization of the human MS4A gene cluster on chromosome 11q12. (PubMed id 11486273)1, 2, 3 Liang Y.... Tedder T.F. (2001)
- Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. (PubMed id 21460840)1 Hollingworth P....Williams J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for MS4A4E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MS4A4E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing MS4A4E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MS4A4E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MS4A4E | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MS4A4E gene:
Search GeneIP for patents involving MS4A4E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MS4A4E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MS4A4E | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MS4A4E | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A4E | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MS4A4E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A4E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A4E |
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| | | | Search Tocris compounds for MS4A4E |
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 | | | MS4A4E Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for MS4A4E |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MS4A4E |
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