Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MS4A4A Gene

protein-coding   GIFtS: 48
GCID: GC11P060048

Membrane-Spanning 4-Domains, Subfamily A, Member 4A

(Previous names: membrane-spanning 4-domains, subfamily A, member 4)
(Previous symbol: MS4A4)
Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 4A1 2     CD20 Antigen-Like 12 3
MS4A41 2 3 5     CD20-L12
Membrane-Spanning 4-Domains, Subfamily A, Member 41 2     MS4A72
Four-Span Transmembrane Protein 12 3     Fc Epsilon Receptor Beta Subunit Homolog2
4SPAN12 3     Membrane-Spanning 4-Domains Subfamily A Member 4A2
CD20L12 3     

External Ids:    HGNC: 133711   Entrez Gene: 513382   Ensembl: ENSG000001100797   OMIM: 6065475   UniProtKB: Q96JQ53   

Export aliases for MS4A4A gene to outside databases

Previous GC identifers: GC11P062442 GC11P061561 GC11P060298 GC11P059823 GC11P059804 GC11P056394


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MS4A4A Gene:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are
characterized by common structural features, similar intron/exon splice boundaries, and display unique expression
patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for MS4A4A Gene: 
MS4A4A (membrane-spanning 4-domains, subfamily A, member 4A) is a protein-coding gene. Diseases associated with MS4A4A include alzheimer's disease. An important paralog of this gene is MS4A18.

UniProtKB/Swiss-Prot: M4A4A_HUMAN, Q96JQ5
Function: May be involved in signal transduction as a component of a multimeric receptor complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MS4A4A gene promoter:
         Nkx3-1   Nkx3-1 v2   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A4A promoter sequence
   Search SABiosciences Chromatin IP Primers for MS4A4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12

MS4A4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A4A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060048:  view genomic region     (about GC identifiers)

Start:
60,048,014 bp from pter      End:
60,076,445 bp from pter
Size:
28,432 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M4A4A_HUMAN, Q96JQ5 (See protein sequence)
Recommended Name: Membrane-spanning 4-domains subfamily A member 4A  
Size: 239 amino acids; 25441 Da
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAF65507.1; Type=Frameshift; Positions=33; Sequence=AAK37594.1; Type=Erroneous
initiation; Sequence=AAL08486.1; Type=Erroneous initiation; Sequence=AAL56220.1; Type=Erroneous initiation;
Sequence=BAB18738.1; Type=Frameshift; Positions=34;
Secondary accessions: Q8TEZ6 Q96PG7 Q9BY18 Q9H3V3 Q9P1S3
Alternative splicing: 2 isoforms:  Q96JQ5-1   Q96JQ5-2   

Explore the universe of human proteins at neXtProt for MS4A4A: NX_Q96JQ5

Explore proteomics data for MS4A4A at MOPED 

MS4A4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MS4A4A Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001230195.1  NP_076926.2  NP_683876.1  

ENSEMBL proteins: 
 ENSP00000434506   ENSP00000338648   ENSP00000340356   ENSP00000435309   ENSP00000434983  
 ENSP00000347252   ENSP00000378462  

Human Recombinant Protein Products for MS4A4A: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for MS4A4A
OriGene Custom MassSpec 
OriGene Custom Protein Services for MS4A4A
GenScript Custom Purified and Recombinant Proteins Services for MS4A4A
Novus Biologicals MS4A4A Protein
Novus Biologicals MS4A4A Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

MS4A4A for ontologies           About GeneDecksing



MS4A4A Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for MS4A4A
Browse OriGene Antibodies
OriGene Custom Antibody Services for MS4A4A
GenScript Custom Superior Antibodies Services for MS4A4A
Novus Biologicals MS4A4A Antibodies
Abcam antibodies for MS4A4A
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibodies for MS4A4A
LSBio Antibodies in human, mouse, rat for MS4A4A 

Assay Products for MS4A4A: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for MS4A4A
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for MS4A4A
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR007237 CD20-like

Graphical View of Domain Structure for InterPro Entry Q96JQ5

ProtoNet protein and cluster: Q96JQ5

1 Blocks protein domain: IPB007237 CD20/IgE Fc receptor beta subunit

UniProtKB/Swiss-Prot: M4A4A_HUMAN, Q96JQ5
Similarity: Belongs to the MS4A family


MS4A4A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: M4A4A_HUMAN, Q96JQ5
Function: May be involved in signal transduction as a component of a multimeric receptor complex

Animal Models:

   inGenious Targeting Laboratory - Custom generated mouse model solutions for MS4A4A 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MS4A4A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MS4A4A 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MS4A4A 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MS4A4A
3 QIAGEN miScript miRNA Assays for microRNAs that regulate MS4A4A:
hsa-miR-1276 hsa-miR-1252 hsa-miR-1267
SwitchGear 3'UTR luciferase reporter plasmidMS4A4A 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MS4A4A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MS4A4A

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MS4A4A
Sirion Biotech Customized adenovirus for overexpression of MS4A4A

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for MS4A4A (see all 13)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): MS4A4A (NM_148975)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MS4A4A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A4A
Sirion Biotech Customized lentivirus for stable overexpression of MS4A4A 
                     Customized lentivirus expression plasmids for stable overexpression of MS4A4A 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for MS4A4A
Search LifeMap BioReagents cell lines for MS4A4A
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A4A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MS4A4A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MS4A4A (M4A4A)

Search CenterWatch for drugs/clinical trials and news about MS4A4A / M4A4A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MS4A4A gene (3 alternative transcripts): 
NM_001243266.1  NM_024021.3  NM_148975.2  

Unigene Cluster for MS4A4A:

Membrane-spanning 4-domains, subfamily A, member 4A
Hs.325960  [show with all ESTs]
Unigene Representative Sequence: BX641064
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000532114 ENST00000337908(uc001noz.3 uc001npc.3) ENST00000343968
ENST00000527056 ENST00000529950 ENST00000529991 ENST00000355131(uc001npa.3)
ENST00000395016

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MS4A4A
3 QIAGEN miScript miRNA Assays for microRNAs that regulate MS4A4A:
hsa-miR-1276 hsa-miR-1252 hsa-miR-1267
SwitchGear 3'UTR luciferase reporter plasmidMS4A4A 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MS4A4A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MS4A4A
Clone
Products:
     
OriGene clones in human, mouse for MS4A4A (see all 13)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): MS4A4A (NM_148975)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MS4A4A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A4A
Sirion Biotech Customized lentivirus for stable overexpression of MS4A4A 
                     Customized lentivirus expression plasmids for stable overexpression of MS4A4A 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MS4A4A
OriGene qSTAR qPCR primer pairs in human, mouse for MS4A4A
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MS4A4A
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A4A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A4A

Additional mRNA sequence: 

AB013102.1 AB022821.1 AF068288.1 AF237912.1 AF350500.1 AF354928.1 AK075081.1 AK292089.1 
AK314033.1 BC020648.1 BX641064.1 

6 DOTS entries:

DT.455264  DT.97839710  DT.86849099  DT.101982294  DT.100785648  DT.101982293 

24/120 AceView cDNA sequences (see all 120):

BX382378 CR605689 BU751796 AI033224 CR622830 AW105367 BF115111 AW004907 
BQ447439 AI767963 AI361461 AI188960 AF350500 AA557621 CD366444 AI700946 
AA056658 BF594184 CA309706 AA723866 AI361031 AF068288 AI361934 CD366321 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MS4A4A    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:                                                                              
SP2:              -     -                 -                                       
SP3:                                      -                                       
SP4:                                      -           -                           


ECgene alternative splicing isoforms for MS4A4A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MS4A4A expression in normal human tissues (normalized intensities)      MS4A4A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAAATTACC
MS4A4A Expression
About this image


MS4A4A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Blood (Respiratory System)    fully expand to see all 2 entries
         monocyte-derived macrophage   
 
 Lung (Respiratory System)
         alveolar macrophages   
 
 Endothelium (Cardiovascular System)
         Peripheral blood-derived early endothelial progenitor cells
 
 Eye (Sensory Organs)
         Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
 
 Placenta (Extraembryonic Tissues)

See MS4A4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MS4A4A

SOURCE GeneReport for Unigene cluster: Hs.325960

UniProtKB/Swiss-Prot: M4A4A_HUMAN, Q96JQ5
Tissue specificity: Variable expression in multiple hemopoietic cell lines

    SABiosciences Custom PCR Arrays for MS4A4A
Primer
Products:
OriGene qPCR primer pairs and template standards for MS4A4A
OriGene qSTAR qPCR primer pairs in human, mouse for MS4A4A
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MS4A4A
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A4A
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A4A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A4A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MS4A4A gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ms4a4a1 , 5 membrane-spanning 4-domains, subfamily A, member 4A1, 5 70.66(n)1
61.29(a)1
  19 (8.44 cM)5
6669071  XM_986941.21  XP_992035.21 
 113755235 
lizard
(Anolis carolinensis)
Reptilia --
--
--
28(a)
19(a)
possible ortholog
possible ortholog
GL343276.1(314310-322731)
GL343235.1(295317-310525)
zebrafish
(Danio rerio)
Actinopterygii ms4a17a.146
CU694374.36
(see all 19)
Uncharacterized protein
(see all 19)
32(a)
29(a)
(see all 19)
many ↔ many
many ↔ many
(see all 19)
4(60581972-60613219)
4(60787636-60793140)


ENSEMBL Gene Tree for MS4A4A (if available)
TreeFam Gene Tree for MS4A4A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MS4A4A gene
MS4A182  MS4A82  MS4A122  MS4A152  
4 SIMAP similar genes for MS4A4A using alignment to 3 protein entries:     M4A4A_HUMAN (see all proteins):
MS4A4E    MS4A5    MS4A3    MS4A8

MS4A4A for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for MS4A4A
PGOHUM00000250374 PGOHUM00000257833


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/581 SNPs in MS4A4A are shown (see all 581)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1408415091,2
--56392863(+) ATATAC/TATTTC 3 -- us2k10--------
rs1847940741,2
--56392904(+) AAATTA/GTTATC 3 -- us2k10--------
rs122836011,2
C,F--56392957(+) AGTGGG/AAGGAG 3 -- us2k1 trp36Minor allele frequency- A:0.24WA NA CSA EA 364
rs750117031,2
C,F--56392972(+) TGATGC/ACTGTC 3 -- us2k11Minor allele frequency- A:0.03WA 118
rs769347261,2
F--56393125(+) ACTGTC/TTCTAT 3 -- us2k11Minor allele frequency- T:0.09WA 118
rs108970221,2
C,F,A--56393151(+) TTTGAC/TGTTTT 3 -- us2k16Minor allele frequency- T:0.23WA NA CSA EA 364
rs108970231,2
C,A--56393152(+) TTGACA/GTTTTC 3 -- us2k111Minor allele frequency- G:0.46NA WA CSA EA 372
rs1145705541,2
F--56393233(+) ATGTTC/TTCATT 3 -- us2k11Minor allele frequency- T:0.09WA 118
rs1895917161,2
C--56393427(+) CTTTCC/TTGTTT 3 -- us2k10--------
rs1502086051,2
--56393457(+) CCATTA/TTACCA 3 -- us2k10--------

HapMap Linkage Disequilibrium report for MS4A4A (60048014 - 60076445 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MS4A4A:    About this table     
Variant IDTypeSubtypePubMed ID
nsv832174CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing MS4A4A
DNA2.0 Custom Variant and Variant Library Synthesis for MS4A4A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606547    OMIM disorders: --

2 diseases for MS4A4A:    About MalaCards
alzheimer's disease    


MS4A4A for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): MS4A4A

Export disorders for MS4A4A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MS4A4A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MS4A4A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PubMed id 11245982)1, 2, 3 Ishibashi K.... Imai M. (2001)
  2. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PubMed id 11401424)1, 2, 3 Liang Y. and Tedder T.F. (2001)
  3. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PubMed id 11486273)1, 2, 9 Liang Y.... Tedder T.F. (2001)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA 1 are associated with late-onset Alzheimer's disease. (PubMed id 21460841)1 Naj A.C....Schellenberg G.D. (2011)
  6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  9. Identification of MarvelD3 as a tight junction-associ ated transmembrane protein of the occludin family. (PubMed id 20028514)9 Steed E....Matter K. (2009)
  10. Barriers built on claudins. (PubMed id 15159449)9 Turksen K. and Troy T.C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 51338 HGNC: 13371 AceView: MS4A4A Ensembl:ENSG00000110079 euGenes: HUgn51338
ECgene: MS4A4A H-InvDB: MS4A4A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MS4A4A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MS4A4A gene:
Search GeneIP for patents involving MS4A4A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for MS4A4A (MS4A4A)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 cDNA Clones for MS4A4A (MS4A4A)   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MS4A4A  
 OriGene qPCR primer pairs and template standards for MS4A4A   OriGene Protein Over-expression Lysate for MS4A4A  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for MS4A4A  
 OriGene qSTAR qPCR primer pairs in human, mouse for MS4A4A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for MS4A4A   OriGene Custom Protein Services for MS4A4A  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MS4A4A
 QIAGEN SeqTarget long-range PCR primers for resequencing MS4A4A
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A4A
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MS4A4A
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A4A
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A4A
 GenScript Custom Purified and Recombinant Proteins Services for MS4A4A GenScript cDNA clones with any tag delivered in your preferred vector for MS4A4A
 GenScript Custom Assay Services for MS4A4A GenScript Custom Superior Antibodies Services for MS4A4A
 GenScript Custom overexpressing Cell Line Services for MS4A4A CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in MS4A4A promoter
 Search Chromatin IP Primers for MS4A4A
 RT2 qPCR Primer Assay in human, mouse / rat MS4A4A
 Search GNC Networks for MS4A4A
 SABiosciences Custom PCR Arrays for MS4A4A
 Search Tocris compounds for MS4A4A (M4A4A)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 MS4A4A antibodies
 MS4A4A proteins
 MS4A4A lysates
 Antibodies for MS4A4A
 See all of Abcam's Antibodies, Kits and Proteins for MS4A4A
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for MS4A4A
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A4A
 SwitchGear 3'UTR luciferase reporter plasmids for MS4A4A
 SwitchGear Promoter luciferase reporter plasmids for MS4A4A
 ThermoFisher Antibodies for MS4A4A
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A4A
 inGenious Targeting Laboratory - Custom generated mouse model solutions for MS4A4A
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MS4A4A
Customized:
 lentivirus for stable overexpression of MS4A4A
 lentivirus expression plasmids for stable overexpression of MS4A4A
 adenovirus for overexpression of MS4A4A
 LSBio Antibodies in human, mouse, rat for MS4A4A
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      MS4A4A gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4