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Aliases for MS4A4A Gene

Aliases for MS4A4A Gene

  • Membrane Spanning 4-Domains A4A 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 4 2 3
  • Four-Span Transmembrane Protein 1 3 4
  • CD20 Antigen-Like 1 3 4
  • 4SPAN1 3 4
  • CD20L1 3 4
  • MS4A4 3 4
  • Membrane-Spanning 4-Domains, Subfamily A, Member 4A 2
  • Membrane-Spanning 4-Domains Subfamily A Member 4A 3
  • Fc Epsilon Receptor Beta Subunit Homolog 3
  • HDCME31P 3
  • CD20-L1 3
  • MS4A7 3

External Ids for MS4A4A Gene

Previous HGNC Symbols for MS4A4A Gene

  • MS4A4

Previous GeneCards Identifiers for MS4A4A Gene

  • GC11P062442
  • GC11P061561
  • GC11P059823
  • GC11P059804
  • GC11P060048
  • GC11P056394

Summaries for MS4A4A Gene

Entrez Gene Summary for MS4A4A Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for MS4A4A Gene

MS4A4A (Membrane Spanning 4-Domains A4A) is a Protein Coding gene. An important paralog of this gene is MS4A4E.

UniProtKB/Swiss-Prot for MS4A4A Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A4A Gene

Genomics for MS4A4A Gene

Regulatory Elements for MS4A4A Gene

Enhancers for MS4A4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G060366 1.4 FANTOM5 ENCODE dbSUPER 10.7 +86.9 86938 1.7 TBL1XR1 EBF1 RELA ARID3A CBX5 EED ZNF143 RELB IKZF2 MAZ MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
GH11G060363 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +83.4 83407 1.7 PKNOX1 RAD21 CHAMP1 ZNF143 ZNF207 THAP11 ZNF654 ZBTB11 REST ZNF589 MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A GC11P060374
GH11G060280 0.9 FANTOM5 Ensembl ENCODE 8 +0.4 417 1.9 SPI1 MS4A6E MS4A7 MS4A4A MS4A6A GC11M060297
GH11G060251 0.9 Ensembl ENCODE 5.9 -28.6 -28552 1.2 CTCF WRNIP1 TRIM22 REST RAD21 CHAMP1 SMC3 ZNF143 ZBTB33 MS4A6E OOSP2 MS4A6A MS4A4A MS4A4E
GH11G060204 0.8 dbSUPER 5.2 -74.8 -74759 3.4 PKNOX1 BMI1 GATA2 FOS ETV6 RELB IKZF2 CREM CBFB JUNB TCN1 OOSP2 MS4A6A MS4A4E MS4A4A MIR6503
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MS4A4A on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A4A Gene

Chromosome:
11
Start:
60,280,541 bp from pter
End:
60,308,972 bp from pter
Size:
28,432 bases
Orientation:
Plus strand

Genomic View for MS4A4A Gene

Genes around MS4A4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A4A Gene

Proteins for MS4A4A Gene

  • Protein details for MS4A4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JQ5-M4A4A_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 4A
    Protein Accession:
    Q96JQ5
    Secondary Accessions:
    • Q8TEZ6
    • Q96PG7
    • Q9BY18
    • Q9H3V3
    • Q9P1S3

    Protein attributes for MS4A4A Gene

    Size:
    239 amino acids
    Molecular mass:
    25441 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF65507.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305}; Sequence=AAK37594.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL08486.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL56220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB18738.1; Type=Frameshift; Positions=34; Evidence={ECO:0000305};

    Alternative splice isoforms for MS4A4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MS4A4A Gene

Post-translational modifications for MS4A4A Gene

No Post-translational modifications

Other Protein References for MS4A4A Gene

No data available for DME Specific Peptides for MS4A4A Gene

Domains & Families for MS4A4A Gene

Gene Families for MS4A4A Gene

Protein Domains for MS4A4A Gene

Suggested Antigen Peptide Sequences for MS4A4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JQ5

UniProtKB/Swiss-Prot:

M4A4A_HUMAN :
  • Belongs to the MS4A family.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A4A: view

Function for MS4A4A Gene

Molecular function for MS4A4A Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A4A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MS4A4A

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A4A Gene

Localization for MS4A4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A4A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A4A gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for MS4A4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A4A: view

Pathways & Interactions for MS4A4A Gene

SuperPathways for MS4A4A Gene

No Data Available

Interacting Proteins for MS4A4A Gene

Selected Interacting proteins: Q96JQ5-M4A4A_HUMAN for MS4A4A Gene via IID

Gene Ontology (GO) - Biological Process for MS4A4A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MS4A4A Gene

Drugs & Compounds for MS4A4A Gene

No Compound Related Data Available

Transcripts for MS4A4A Gene

Unigene Clusters for MS4A4A Gene

Membrane-spanning 4-domains, subfamily A, member 4A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A4A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for MS4A4A Gene

GeneLoc Exon Structure for
MS4A4A
ECgene alternative splicing isoforms for
MS4A4A

Expression for MS4A4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A4A Gene

This gene is overexpressed in Whole Blood (x7.0), Adipose - Visceral (Omentum) (x4.8), and Spleen (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of MS4A4A Gene:

MS4A4A

SOURCE GeneReport for Unigene cluster for MS4A4A Gene:

Hs.325960

mRNA Expression by UniProt/SwissProt for MS4A4A Gene:

Q96JQ5-M4A4A_HUMAN
Tissue specificity: Variable expression in multiple hemopoietic cell lines.

Evidence on tissue expression from TISSUES for MS4A4A Gene

  • Spleen(4.4)
  • Lymph node(4.3)
  • Blood(4)
genes like me logo Genes that share expression patterns with MS4A4A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A4A Gene

Orthologs for MS4A4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A4A 34 35
  • 99.58 (n)
mouse
(Mus musculus)
Mammalia Ms4a4a 34 16
  • 70.49 (n)
Ms4a4c 35
  • 40 (a)
OneToMany
Ms4a4b 35
  • 38 (a)
OneToMany
Ms4a4d 35
  • 37 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC476900 34
  • 67.8 (n)
MS4A4A 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 33 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ms4a17a.14 35
  • 32 (a)
ManyToMany
ms4a17a.10 35
  • 29 (a)
ManyToMany
ms4a17a.7 35
  • 29 (a)
ManyToMany
FP015791.1 35
  • 28 (a)
ManyToMany
ms4a17a.11 35
  • 28 (a)
ManyToMany
ms4a17a.5 35
  • 28 (a)
ManyToMany
ms4a17a.9 35
  • 28 (a)
ManyToMany
si:dkey-238j22.1 35
  • 28 (a)
ManyToMany
ms4a17a.1 35
  • 27 (a)
ManyToMany
ms4a17a.2 35
  • 26 (a)
ManyToMany
ms4a17a.6 35
  • 26 (a)
ManyToMany
ms4a17a.8 35
  • 26 (a)
ManyToMany
si:ch73-56d11.3 35
  • 26 (a)
ManyToMany
si:dkey-174k12.3 35
  • 26 (a)
ManyToMany
ms4a17a.3 35
  • 25 (a)
ManyToMany
ms4a17a.4 35
  • 25 (a)
ManyToMany
ms4a17c.2 35
  • 25 (a)
ManyToMany
si:ch73-56d11.4 35
  • 25 (a)
ManyToMany
si:dkey-77f5.10 35
  • 25 (a)
ManyToMany
ms4a17c.1 35
  • 24 (a)
ManyToMany
ms4a17a.17 35
  • 23 (a)
ManyToMany
Species where no ortholog for MS4A4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A4A Gene

ENSEMBL:
Gene Tree for MS4A4A (if available)
TreeFam:
Gene Tree for MS4A4A (if available)

Paralogs for MS4A4A Gene

Paralogs for MS4A4A Gene

(4) SIMAP similar genes for MS4A4A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MS4A4A Gene

genes like me logo Genes that share paralogs with MS4A4A: view

Variants for MS4A4A Gene

Sequence variations from dbSNP and Humsavar for MS4A4A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000071211 -- 60,303,448(+) CACGC(C/T)TGTAA intron-variant
rs1000123367 -- 60,303,232(+) ACTAC(G/T)TTTTT intron-variant
rs1000137497 -- 60,280,845(+) ATTCA(A/G)GGTTG intron-variant
rs1000180184 -- 60,279,557(+) TCCCC(C/T)TATCT upstream-variant-2KB
rs1000639620 -- 60,287,545(+) GAAAC(C/T)ATAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A4A Gene

Variant ID Type Subtype PubMed ID
nsv1053558 CNV loss 25217958
nsv1145537 CNV deletion 24896259
nsv832174 CNV gain 17160897

Variation tolerance for MS4A4A Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MS4A4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A4A Gene

Disorders for MS4A4A Gene

Relevant External Links for MS4A4A

Genetic Association Database (GAD)
MS4A4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MS4A4A

No disorders were found for MS4A4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A4A Gene

Publications for MS4A4A Gene

  1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K. … Imai M. (Gene 2001) 2 3 4 64
  2. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3 4 64
  3. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 3 4 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y. … Tatakis D.N. (J. Clin. Periodontol. 2017) 3 64

Products for MS4A4A Gene

Sources for MS4A4A Gene

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