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Aliases for MS4A4A Gene

Aliases for MS4A4A Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 4A 2 3
  • MS4A4 3 4 6
  • Membrane-Spanning 4-Domains, Subfamily A, Member 4 2 3
  • Four-Span Transmembrane Protein 1 3 4
  • CD20 Antigen-Like 1 3 4
  • 4SPAN1 3 4
  • CD20L1 3 4
  • Membrane-Spanning 4-Domains Subfamily A Member 4A 3
  • Fc Epsilon Receptor Beta Subunit Homolog 3
  • HDCME31P 3
  • CD20-L1 3
  • MS4A7 3

External Ids for MS4A4A Gene

Previous HGNC Symbols for MS4A4A Gene

  • MS4A4

Previous GeneCards Identifiers for MS4A4A Gene

  • GC11P062442
  • GC11P061561
  • GC11P059823
  • GC11P059804
  • GC11P060048
  • GC11P056394

Summaries for MS4A4A Gene

Entrez Gene Summary for MS4A4A Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for MS4A4A Gene

MS4A4A (Membrane-Spanning 4-Domains, Subfamily A, Member 4A) is a Protein Coding gene. An important paralog of this gene is MS4A18.

UniProtKB/Swiss-Prot for MS4A4A Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A4A Gene

Genomics for MS4A4A Gene

Regulatory Elements for MS4A4A Gene

Genomic Location for MS4A4A Gene

60,280,541 bp from pter
60,308,972 bp from pter
28,432 bases
Plus strand

Genomic View for MS4A4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A4A Gene

Proteins for MS4A4A Gene

  • Protein details for MS4A4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 4A
    Protein Accession:
    Secondary Accessions:
    • Q8TEZ6
    • Q96PG7
    • Q9BY18
    • Q9H3V3
    • Q9P1S3

    Protein attributes for MS4A4A Gene

    239 amino acids
    Molecular mass:
    25441 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF65507.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305}; Sequence=AAK37594.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL08486.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL56220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB18738.1; Type=Frameshift; Positions=34; Evidence={ECO:0000305};

    Alternative splice isoforms for MS4A4A Gene


neXtProt entry for MS4A4A Gene

Proteomics data for MS4A4A Gene at MOPED

Post-translational modifications for MS4A4A Gene

No Post-translational modifications

Other Protein References for MS4A4A Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MS4A4A

No data available for DME Specific Peptides for MS4A4A Gene

Domains for MS4A4A Gene

Gene Families for MS4A4A Gene

Protein Domains for MS4A4A Gene

Suggested Antigen Peptide Sequences for MS4A4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A4A: view

Function for MS4A4A Gene

Molecular function for MS4A4A Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex

Animal Model Products

CRISPR Products

miRNA for MS4A4A Gene

miRTarBase miRNAs that target MS4A4A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A4A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A4A Gene

Localization for MS4A4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A4A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MS4A4A Gene COMPARTMENTS Subcellular localization image for MS4A4A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A4A: view

Pathways for MS4A4A Gene

SuperPathways for MS4A4A Gene

No Data Available

Interacting Proteins for MS4A4A Gene

Gene Ontology (GO) - Biological Process for MS4A4A Gene


No data available for Pathways by source for MS4A4A Gene

Transcripts for MS4A4A Gene

Unigene Clusters for MS4A4A Gene

Membrane-spanning 4-domains, subfamily A, member 4A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A4A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for MS4A4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A4A Gene

mRNA expression in normal human tissues for MS4A4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A4A Gene

This gene is overexpressed in Whole Blood (7.0), Adipose - Visceral (Omentum) (4.8), and Spleen (4.5).

SOURCE GeneReport for Unigene cluster for MS4A4A Gene Hs.325960

mRNA Expression by UniProt/SwissProt for MS4A4A Gene

Tissue specificity: Variable expression in multiple hemopoietic cell lines
genes like me logo Genes that share expressions with MS4A4A: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for MS4A4A Gene

Orthologs for MS4A4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A4A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC476900 35
  • 67.8 (n)
  • 53.19 (a)
MS4A4A 36
  • 50 (a)
(Mus musculus)
Mammalia Ms4a4a 35
  • 70.49 (n)
  • 61.01 (a)
Ms4a4a 16
Ms4a4b 36
  • 38 (a)
Ms4a4c 36
  • 40 (a)
Ms4a4d 36
  • 37 (a)
(Pan troglodytes)
Mammalia MS4A4A 35
  • 99.58 (n)
  • 99.16 (a)
MS4A4A 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
-- 36
  • 33 (a)
-- 36
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
-- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
(Danio rerio)
Actinopterygii FP015791.1 36
  • 28 (a)
ms4a17a.1 36
  • 27 (a)
ms4a17a.10 36
  • 29 (a)
ms4a17a.11 36
  • 28 (a)
ms4a17a.14 36
  • 32 (a)
ms4a17a.17 36
  • 23 (a)
ms4a17a.2 36
  • 26 (a)
ms4a17a.3 36
  • 25 (a)
ms4a17a.4 36
  • 25 (a)
ms4a17a.5 36
  • 28 (a)
ms4a17a.6 36
  • 26 (a)
ms4a17a.7 36
  • 29 (a)
ms4a17a.8 36
  • 26 (a)
ms4a17a.9 36
  • 28 (a)
ms4a17c.1 36
  • 24 (a)
ms4a17c.2 36
  • 25 (a)
si:ch73-56d11.3 36
  • 26 (a)
si:ch73-56d11.4 36
  • 25 (a)
si:dkey-174k12.3 36
  • 26 (a)
si:dkey-238j22.1 36
  • 28 (a)
si:dkey-77f5.10 36
  • 25 (a)
Species with no ortholog for MS4A4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A4A Gene

Gene Tree for MS4A4A (if available)
Gene Tree for MS4A4A (if available)

Paralogs for MS4A4A Gene

Paralogs for MS4A4A Gene

(4) SIMAP similar genes for MS4A4A Gene using alignment to 3 proteins: Pseudogenes for MS4A4A Gene

genes like me logo Genes that share paralogs with MS4A4A: view

Variants for MS4A4A Gene

Sequence variations from dbSNP and Humsavar for MS4A4A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs187848628 -- 60,302,368(+) GCTGC(A/G)GAATA intron-variant
rs187695213 -- 60,287,549(+) CCATA(A/G)CATCT intron-variant
rs187621316 -- 60,293,151(+) CTTCC(A/G)GGTTC intron-variant
rs187571961 -- 60,287,079(+) AACCA(C/T)GTAGT intron-variant
rs187570207 -- 60,305,713(+) AAGCT(A/G)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A4A Gene

Variant ID Type Subtype PubMed ID
nsv832174 CNV Gain 17160897

Relevant External Links for MS4A4A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A4A Gene

Disorders for MS4A4A Gene

Relevant External Links for MS4A4A

Genetic Association Database (GAD)

No disorders were found for MS4A4A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MS4A4A Gene

Publications for MS4A4A Gene

  1. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 3 4 23
  2. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PMID: 11245982) Ishibashi K. … Imai M. (Gene 2001) 2 3 4
  3. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3

Products for MS4A4A Gene

Sources for MS4A4A Gene

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