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Aliases for MS4A3 Gene

Aliases for MS4A3 Gene

  • Membrane Spanning 4-Domains A3 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 3 (Hematopoietic Cell-Specific) 2 3
  • Hematopoietic-Specific Transmembrane Protein 4 3 4
  • CD20 Antigen-Like Protein 3 4
  • CD20L 3 4
  • HTM4 3 4
  • Membrane-Spanning 4-Domains Subfamily A Member 3 3
  • Hematopoietic Cell 4 Transmembrane Protein 3
  • IgE Receptor Beta Subunit 3
  • IgE Receptor Beta Chain 3
  • CD20 Antigen Homolog 3

External Ids for MS4A3 Gene

Previous HGNC Symbols for MS4A3 Gene

  • CD20L

Previous GeneCards Identifiers for MS4A3 Gene

  • GC11P062218
  • GC11P061337
  • GC11P059599
  • GC11P059580
  • GC11P059824
  • GC11P056172

Summaries for MS4A3 Gene

Entrez Gene Summary for MS4A3 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A3 Gene

MS4A3 (Membrane Spanning 4-Domains A3) is a Protein Coding gene. Among its related pathways are Immune System. An important paralog of this gene is MS4A2.

UniProtKB/Swiss-Prot for MS4A3 Gene

  • Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).

Gene Wiki entry for MS4A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A3 Gene

Genomics for MS4A3 Gene

Regulatory Elements for MS4A3 Gene

Enhancers for MS4A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F059968 0.7 FANTOM5 11.1 -88.3 -88316 0.3 HDAC1 CBX3 ATF1 ARNT TBL1XR1 NFRKB CHAMP1 ELK1 GATA2 CREM OOSP2 MS4A3 MS4A2 MRPL16 OOSP1 LOC105369444
GH11F060058 0.9 Ensembl 5 +2.1 2114 0.2 MS4A3 YWHAZP9
GH11F060100 1 FANTOM5 Ensembl ENCODE 2.2 +44.6 44556 1.7 ARID1B TAL1 ZBTB33 MS4A6A LOC105369318 MS4A3 MRPL16 MS4A2 LOC105369319
GH11F060056 0.7 Ensembl 0.8 +0.4 400 1.6 HDAC1 CBX3 PKNOX1 TBL1XR1 TAL1 GTF2E2 CHAMP1 IRF9 GATA2 NCOR1 MS4A3 YWHAZP9
GH11F060055 0.2 Ensembl 0.8 -1.0 -987 0.4 CTCF TFAP4 ATF1 CBX3 GTF2E2 CEBPG RAD21 CHAMP1 IRF9 SMC3 MS4A3 OOSP2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MS4A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A3 Gene

Chromosome:
11
Start:
60,056,587 bp from pter
End:
60,071,128 bp from pter
Size:
14,542 bases
Orientation:
Plus strand

Genomic View for MS4A3 Gene

Genes around MS4A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A3 Gene

Proteins for MS4A3 Gene

  • Protein details for MS4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HJ5-MS4A3_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 3
    Protein Accession:
    Q96HJ5
    Secondary Accessions:
    • A8MTP8
    • Q8NHW2

    Protein attributes for MS4A3 Gene

    Size:
    214 amino acids
    Molecular mass:
    22933 Da
    Quaternary structure:
    • Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.

    Alternative splice isoforms for MS4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MS4A3 Gene

Post-translational modifications for MS4A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MS4A3 Gene

Domains & Families for MS4A3 Gene

Gene Families for MS4A3 Gene

Protein Domains for MS4A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MS4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HJ5

UniProtKB/Swiss-Prot:

MS4A3_HUMAN :
  • The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.
  • Belongs to the MS4A family.
Domain:
  • The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A3: view

Function for MS4A3 Gene

Molecular function for MS4A3 Gene

GENATLAS Biochemistry:
membrane-spanning 4-domains,subfamily A,member 3,hematopoietic cell-specific
UniProtKB/Swiss-Prot Function:
Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).

Gene Ontology (GO) - Molecular Function for MS4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15671017
genes like me logo Genes that share ontologies with MS4A3: view
genes like me logo Genes that share phenotypes with MS4A3: view

Animal Model Products

miRNA for MS4A3 Gene

miRTarBase miRNAs that target MS4A3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A3 Gene

Localization for MS4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A3 Gene

Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear area.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A3 Gene COMPARTMENTS Subcellular localization image for MS4A3 gene
Compartment Confidence
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MS4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MS4A3: view

Pathways & Interactions for MS4A3 Gene

SuperPathways for MS4A3 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with MS4A3: view

Pathways by source for MS4A3 Gene

2 Reactome pathways for MS4A3 Gene

Interacting Proteins for MS4A3 Gene

Gene Ontology (GO) - Biological Process for MS4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with MS4A3: view

No data available for SIGNOR curated interactions for MS4A3 Gene

Transcripts for MS4A3 Gene

Unigene Clusters for MS4A3 Gene

Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: -

Relevant External Links for MS4A3 Gene

GeneLoc Exon Structure for
MS4A3
ECgene alternative splicing isoforms for
MS4A3

Expression for MS4A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MS4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A3 Gene

This gene is overexpressed in Whole Blood (x45.8).

NURSA nuclear receptor signaling pathways regulating expression of MS4A3 Gene:

MS4A3

SOURCE GeneReport for Unigene cluster for MS4A3 Gene:

Hs.99960

mRNA Expression by UniProt/SwissProt for MS4A3 Gene:

Q96HJ5-MS4A3_HUMAN
Tissue specificity: Expressed specifically in hematopoietic cells and tissues.
genes like me logo Genes that share expression patterns with MS4A3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MS4A3 Gene

Orthologs for MS4A3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A3 34 35
  • 95.17 (n)
mouse
(Mus musculus)
Mammalia Ms4a3 34 16 35
  • 73.94 (n)
rat
(Rattus norvegicus)
Mammalia Ms4a3 34
  • 72.12 (n)
cow
(Bos Taurus)
Mammalia MS4A3 34 35
  • 63.48 (n)
oppossum
(Monodelphis domestica)
Mammalia MS4A3 35
  • 45 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
OneToMany
Species where no ortholog for MS4A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A3 Gene

ENSEMBL:
Gene Tree for MS4A3 (if available)
TreeFam:
Gene Tree for MS4A3 (if available)

Paralogs for MS4A3 Gene

Paralogs for MS4A3 Gene

(1) SIMAP similar genes for MS4A3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MS4A3: view

Variants for MS4A3 Gene

Sequence variations from dbSNP and Humsavar for MS4A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10897002 -- 60,058,563(+) GAGCA(A/G)AAATT intron-variant
rs10897003 -- 60,070,104(+) ATGAA(A/T)GGATT intron-variant
rs111425647 -- 60,063,355(+) TAGGG(G/T)TGATT intron-variant
rs111442627 -- 60,069,808(+) ATTGT(A/G)TGAAT intron-variant
rs111544468 -- 60,070,304(+) TTCAC(C/G)CACAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MS4A3 Gene

Variant ID Type Subtype PubMed ID
nsv336 CNV insertion 18451855
nsv468579 CNV gain 19166990
nsv509411 CNV insertion 20534489
nsv555150 CNV gain 21841781
nsv832173 CNV gain 17160897

Variation tolerance for MS4A3 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A3 Gene

Human Gene Mutation Database (HGMD)
MS4A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MS4A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A3 Gene

Disorders for MS4A3 Gene

Relevant External Links for MS4A3

Genetic Association Database (GAD)
MS4A3
Human Genome Epidemiology (HuGE) Navigator
MS4A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MS4A3

No disorders were found for MS4A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A3 Gene

Publications for MS4A3 Gene

  1. Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions. (PMID: 7524084) Adra C.N. … Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 22 64
  2. Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. (PMID: 15671017) Chinami M. … Adra C.N. (J. Biol. Chem. 2005) 3 4 22 64
  3. Human HTm4 is a hematopoietic cell cycle regulator. (PMID: 11781350) Donato J.-L. … Adra C.N. (J. Clin. Invest. 2002) 3 4 22 64
  4. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PMID: 22367966) Lin X. … Sun J. (Hum. Mol. Genet. 2012) 3 46 64
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64

Products for MS4A3 Gene

Sources for MS4A3 Gene

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