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MS4A3 Gene

protein-coding   GIFtS: 54
GCID: GC11P059824

Membrane-Spanning 4-Domains, Subfamily A, Member 3 (Hematopoietic...


(Previous symbol: CD20L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 3 (Hematopoietic
Cell-Specific)1 2
     Hematopoietic Cell 4 Transmembrane Protein2
CD20L1 2 3 5     IgE Receptor Beta Chain2
HTM42 3 5     IgE Receptor Beta Subunit2
Hematopoietic-Specific Transmembrane Protein 42 3     Membrane-Spanning 4-Domains Subfamily A Member 32
CD20 Antigen-Like Protein2 3     HTm43
CD20 Antigen Homolog2     

External Ids:    HGNC: 73171   Entrez Gene: 9322   Ensembl: ENSG000001495167   OMIM: 6064985   UniProtKB: Q96HJ53   

Export aliases for MS4A3 gene to outside databases

Previous GC identifers: GC11P062218 GC11P061337 GC11P060074 GC11P059599 GC11P059580 GC11P056172


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MS4A3 Gene:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are
characterized by common structural features and similar intron/exon splice boundaries and display unique
expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in
signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this
protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in
multiple transcript variants; however, not all variants have been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for MS4A3 Gene:
MS4A3 (membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)) is a protein-coding gene. Diseases associated with MS4A3 include narcolepsy, and hepatitis b. An important paralog of this gene is MS4A2.

UniProtKB/Swiss-Prot: MS4A3_HUMAN, Q96HJ5
Function: Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of
cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP)

Gene Wiki entry for MS4A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MS4A3 gene promoter:
         TBP   C/EBPbeta   AML1a   IRF-1   Nkx5-1   POU3F2   FOXL1   RORalpha2   IRF-2   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A3 promoter sequence
   Search Chromatin IP Primers for MS4A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MS4A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12-q13.1

MS4A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059824:  view genomic region     (about GC identifiers)

Start:
59,824,060 bp from pter      End:
59,838,601 bp from pter
Size:
14,542 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MS4A3_HUMAN, Q96HJ5 (See protein sequence)
Recommended Name: Membrane-spanning 4-domains subfamily A member 3  
Size: 214 amino acids; 22933 Da
Subunit: Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction
facilitates dissociation of cyclin A from CDKN3-CDK2 complexes
Secondary accessions: A8MTP8 Q8NHW2
Alternative splicing: 3 isoforms:  Q96HJ5-1   Q96HJ5-2   Q96HJ5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MS4A3: NX_Q96HJ5

Explore proteomics data for MS4A3 at MOPED


See MS4A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001026836.1  NP_001026979.1  NP_006129.4  

ENSEMBL proteins: 
 ENSP00000378473   ENSP00000278865   ENSP00000434109   ENSP00000434117   ENSP00000350872  

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MS4A3 Assay Products:

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Cloud-Clone Corp. CLIAs for MS4A3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007237 CD20-like

Graphical View of Domain Structure for InterPro Entry Q96HJ5

ProtoNet protein and cluster: Q96HJ5

UniProtKB/Swiss-Prot: MS4A3_HUMAN, Q96HJ5
Domain: The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity
Similarity: Belongs to the MS4A family


MS4A3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MS4A3_HUMAN, Q96HJ5
Function: Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of
cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP)

     Genatlas biochemistry entry for MS4A3:
membrane-spanning 4-domains,subfamily A,member 3,hematopoietic cell-specific

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI15671017
     
MS4A3 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for MS4A3:
 Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MS4A3
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MS4A3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MS4A3

miRNA
Products:
    
miRTarBase miRNAs that target MS4A3:
hsa-mir-150-5p (MIRT021210)

Block miRNA regulation of human, mouse, rat MS4A3 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate MS4A3:
hsa-miR-509-3p
SwitchGear 3'UTR luciferase reporter plasmidMS4A3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MS4A3
Predesigned siRNA for gene silencing in human, mouse, rat MS4A3

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 3): MS4A3 (NM_001031666)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A3

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MS4A3_HUMAN, Q96HJ5: Endomembrane system; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear
region (By similarity). Note=Located in the perinuclear area
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
cytosol1
nucleus1
peroxisome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0012505endomembrane system IEA--
GO:0016021integral component of membrane IEA--
GO:0048471perinuclear region of cytoplasm IEA--

MS4A3 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MS4A3
Interactions:

    GeneGlobe Interaction Network for MS4A3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for MS4A3 (Q96HJ53 ENSP000002788654) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CDKN3Q166673, ENSP000003353574I2D: score=2 STRING: ENSP00000335357
CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MS4A3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MS4A3 gene (3 alternative transcripts): 
NM_001031666.1  NM_001031809.1  NM_006138.4  

Unigene Cluster for MS4A3:

Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
Hs.99960  [show with all ESTs]
Unigene Representative Sequence: NM_006138
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000395032 ENST00000528298 ENST00000278865(uc001nom.3) ENST00000525686
ENST00000526199 ENST00000534744 ENST00000528952 ENST00000358152(uc001non.3 uc001noo.3)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MS4A3 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate MS4A3:
hsa-miR-509-3p
SwitchGear 3'UTR luciferase reporter plasmidMS4A3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MS4A3
Predesigned siRNA for gene silencing in human, mouse, rat MS4A3
Clone
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OriGene ORF clones in mouse, rat for MS4A3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): MS4A3 (NM_001031666)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MS4A3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for MS4A3
OriGene qSTAR qPCR primer pairs in human, mouse for MS4A3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MS4A3
  QuantiTect SYBR Green Assays in human, mouse, rat MS4A3
  QuantiFast Probe-based Assays in human, mouse, rat MS4A3

Additional mRNA sequence: 

AY095480.1 BC008487.1 L35848.1 

5 DOTS entries:

DT.102798  DT.95164966  DT.120680427  DT.100737027  DT.91766584 

Selected AceView cDNA sequences (see all 70):

CR612051 AL531049 AW440753 BC008487 AW467382 AY095480 BG184925 BG776839 
AL601630 BI019914 BG495708 BF210971 BF210675 BG494779 NM_006138 BG484448 
BF184815 BG527223 BG195938 BG776284 BE564041 L35848 BF903045 AW195127 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MS4A3 (see all 7)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:                                                  -           -                                       
SP2:                                                        -     -                                       
SP3:                                      -     -     -     -     -                                       
SP4:                                                  -     -     -     -                                 
SP5:                                      -     -     -           -                                       


ECgene alternative splicing isoforms for MS4A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MS4A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCAAATTAT
MS4A3 Expression
About this image


MS4A3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Cerebral Cortex
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood
 
 Bone (Muscoskeletal System)
         Bone Marrow
MS4A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MS4A3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.99960

UniProtKB/Swiss-Prot: MS4A3_HUMAN, Q96HJ5
Tissue specificity: Expressed specifically in hematopoietic cells and tissues

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QuantiFast Probe-based Assays in human, mouse, rat MS4A3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for MS4A3 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ms4a31 , 5 membrane-spanning 4-domains, subfamily A, member 31, 5 73.94(n)1
64.36(a)1
  19 (8.47 cM)5
1708131  NM_133246.41  NP_573509.11 
 116294975 


ENSEMBL Gene Tree for MS4A3 (if available)
TreeFam Gene Tree for MS4A3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MS4A3 gene
MS4A22  
1 SIMAP similar gene for MS4A3 using alignment to 2 protein entries:     MS4A3_HUMAN (see all proteins):
MS4A4A

MS4A3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MS4A3 (see all 378)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs354084001,2
C--56172029(+) GATTTTG/-TGTGT 3 -- int11Minor allele frequency- -:0.50CSA 2
rs714564051,2
C--56172030(+) ATTTTGT/-GTGTG 3 -- int11Minor allele frequency- -:0.50NA 2
rs1394692671,2
C--59822231(+) GCACTA/GTGATC 3 -- us2k10--------
rs1452798581,2
--59822586(+) GGGCTC/TAGGTG 3 -- us2k10--------
rs1472252711,2
--59822591(+) CAGGTG/TCCAGC 3 -- us2k10--------
rs783202751,2
C,F--59822636(+) GGCAAC/TTGGGC 3 -- us2k11Minor allele frequency- T:0.05NA 120
rs1915855231,2
--59822739(+) ACTGAC/TGCTCC 3 -- us2k10--------
rs1486985821,2
--59822740(+) CTGACA/GCTCCT 3 -- us2k10--------
rs1841148421,2
--59822789(+) ATTCTA/TCTCTG 3 -- us2k10--------
rs1132871901,2
F--59822896(+) CTTCAC/TGTTAC 3 -- us2k11Minor allele frequency- T:0.50CSA 2

HapMap Linkage Disequilibrium report for MS4A3 (59824060 - 59838601 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MS4A3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv336CNV Insertion18451855
nsv509411CNV Insertion20534489
nsv468579CNV Gain19166990
nsv832173CNV Gain17160897

Human Gene Mutation Database (HGMD): MS4A3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MS4A3
DNA2.0 Custom Variant and Variant Library Synthesis for MS4A3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606498    OMIM disorders: --

6 diseases for MS4A3:    
About MalaCards
narcolepsy    hepatitis b    asthma    hepatitis
cerebritis    endotheliitis


MS4A3 for disorders           About GeneDecksing

Genetic Association Database (GAD): MS4A3
Human Genome Epidemiology (HuGE) Navigator: MS4A3 (3 documents)

Export disorders for MS4A3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MS4A3 gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with MS4A3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions. (PubMed id 7524084)1, 2, 3, 9 Adra C.N.... Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1994)
  2. Human HTm4 is a hematopoietic cell cycle regulator. (PubMed id 11781350)1, 2, 9 Donato J.-L.... Adra C.N. (J. Clin. Invest. 2002)
  3. Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. (PubMed id 15671017)1, 2, 9 Chinami M.... Adra C.N. (J. Biol. Chem. 2005)
  4. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PubMed id 22367966)1, 4 Lin X....Sun J. (Hum. Mol. Genet. 2012)
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
  6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PubMed id 11401424)1, 9 Liang Y. and Tedder T.F. (Genomics 2001)
  9. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PubMed id 11486273)1, 9 Liang Y.... Tedder T.F. (Immunogenetics 2001)
  10. Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues. (PubMed id 19818099)1 Kutok J.L....Adra C.N. (J. Cell. Mol. Med. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 932 HGNC: 7317 AceView: MS4A3 Ensembl:ENSG00000149516 euGenes: HUgn932
ECgene: MS4A3 H-InvDB: MS4A3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MS4A3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MS4A3 gene:
Search GeneIP for patents involving MS4A3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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