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MS4A2 Gene

protein-coding   GIFtS: 65
GCID: GC11P059856

Membrane-Spanning 4-Domains, Subfamily A, Member 2

(Previous names: IgE responsiveness (atopic), membrane-spanning 4-domains,...)
(Previous symbols: FCER1B, IGER, APY)
  See MS4A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 21 2     IGEL2
FCER1B1 2 3 5     IGHER2
APY1 2 3     MS4A12
IGER1 2 3     Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide2
IgE Fc Receptor Subunit Beta2 3     High Affinity IgE Receptor Beta Subunit2
Fc Fragment Of IgE1     High Affinity Immunoglobulin Epsilon Receptor Beta-Subunit (FcERI) (IgE Fc
Receptor, Beta-Subunit) (Fc Epsilon Receptor I Beta-Chain)2
High Affinity I1     High Affinity Immunoglobulin Epsilon Receptor Subunit Beta2
IgE Responsiveness (Atopic)1     Immunoglobulin E Receptor, High Affinity, Beta Polypeptide2
Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment Of IgE,
High Affinity I, Receptor For; Beta Polypeptide)1
     FcERI3
Receptor For; Beta Polypeptide1     Fc Epsilon Receptor I Beta-Chain3
ATOPY2     Membrane-Spanning 4-Domains Subfamily A Member 23
FCERI2     

External Ids:    HGNC: 73161   Entrez Gene: 22062   Ensembl: ENSG000001495347   OMIM: 1471385   UniProtKB: Q013623   

Export aliases for MS4A2 gene to outside databases

Previous GC identifers: GC11P062251 GC11P061369 GC11P060107 GC11P059631 GC11P059612 GC11P056203


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MS4A2 Gene:
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the
release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an
alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene
encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene
family. Members of this nascent protein family are characterized by common structural features and similar
intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid
tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members.
Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript
variants have been described but require experimental validation. (provided by RefSeq, Mar 2012)

GeneCards Summary for MS4A2 Gene:
MS4A2 (membrane-spanning 4-domains, subfamily A, member 2) is a protein-coding gene. Diseases associated with MS4A2 include hand dermatosis, and allergic asthma. GO annotations related to this gene include SH2 domain binding and protein kinase binding. An important paralog of this gene is MS4A3.

UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by
multivalent antigens is required for the full mast cell response, including the release of preformed mediators
(such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the
secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the
release of mediators responsible for the manifestations of allergy

Gene Wiki entry for MS4A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MS4A2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A2 promoter sequence
   Search Chromatin IP Primers for MS4A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MS4A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12-q13

MS4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059856:  view genomic region     (about GC identifiers)

Start:
59,855,734 bp from pter      End:
59,865,940 bp from pter
Size:
10,207 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362 (See protein sequence)
Recommended Name: High affinity immunoglobulin epsilon receptor subunit beta  
Size: 244 amino acids; 26534 Da
Subunit: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts
with FGR, FES/FPS and LYN (By similarity)
Secondary accessions: Q54A81

Explore the universe of human proteins at neXtProt for MS4A2: NX_Q01362

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by LYN (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (2 alternative transcripts): 
    NP_000130.1  NP_001243845.1  

    ENSEMBL proteins: 
     ENSP00000433311   ENSP00000278888  
    Reactome Protein details: Q01362

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry Q01362

    ProtoNet protein and cluster: Q01362

    1 Blocks protein domain: IPB007237 CD20/IgE Fc receptor beta subunit

    UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Similarity: Belongs to the MS4A family


    Find genes that share domains with MS4A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCERB_HUMAN, Q01362
    Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by
    multivalent antigens is required for the full mast cell response, including the release of preformed mediators
    (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the
    secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the
    release of mediators responsible for the manifestations of allergy

         Genatlas biochemistry entry for MS4A2:
    membrane-spanning 4-domains, subfamily A, member 2,cell differentiation antigen CD20 (gp35),37/35kDa,identified by
    monoclonal antibodies B1,1F5

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019863IgE binding IEA--
    GO:0019901protein kinase binding IEA--
    GO:0042169SH2 domain binding IEA--
    GO:0051219phosphoprotein binding IEA--
         
    Find genes that share ontologies with MS4A2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MS4A2:
     Decreased POU5F1-GFP protein e 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ms4a2):
     hematopoietic system  immune system 

    Find genes that share phenotypes with MS4A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MS4A2: Ms4a2tm1Knt Ms4a2tm1Chr

       genOway: Develop your customized and physiologically relevant rodent model for MS4A2

    miRNA
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    miRTarBase miRNAs that target MS4A2:
    hsa-mir-335-5p (MIRT017962)

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    hsa-miR-579 hsa-miR-137 hsa-miR-25 hsa-miR-373* hsa-miR-27b* hsa-miR-15b* hsa-miR-520g hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidMS4A2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FCERB_HUMAN, Q01362: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endosome2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS1535625
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with MS4A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MS4A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    Fc epsilon RI signaling pathway0.41
    2PI-3K cascade
    Fc epsilon receptor (FCERI) signaling0.64
    3Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    4Allograft rejection
    Asthma0.46


    Find genes that share SuperPaths with MS4A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for MS4A2
        Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    1 BioSystems Pathway for MS4A2
        Fc-epsilon receptor I signaling in mast cells


    5 Reactome Pathways for MS4A2
        FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    Fc epsilon receptor (FCERI) signaling
    Role of LAT2/NTAL/LAB on calcium mobilization
    FCERI mediated Ca+2 mobilization


    2 Kegg Pathways  (Kegg details for MS4A2):
        Fc epsilon RI signaling pathway
    Asthma

        Pathway & Disease-focused RT2 Profiler PCR Array including MS4A2: 
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MS4A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for MS4A2 (Q013623 ENSP000002788884) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434053, ENSP000003648984I2D: score=2 STRING: ENSP00000364898
    PRKCDQ056553, ENSP000003316024I2D: score=1 STRING: ENSP00000331602
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IMP7920628
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007202activation of phospholipase C activity IEA--

    Find genes that share ontologies with MS4A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MS4A2 (FCERB)

    1 DrugBank Compound for MS4A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Omalizumab-- 242138-07-4targetantagonist17016423 17139284 17073688

    1 Novoseek inferred chemical compound relationship for MS4A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergens 59.6 5 15788141 (3), 11101848 (1), 1741930 (1)



    Find genes that share compounds with MS4A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MS4A2 gene (3 alternative transcripts): 
    NM_000139.4  NM_001256916.1  NM_001142303.1  

    Unigene Cluster for MS4A2:

    Membrane-spanning 4-domains, subfamily A, member 2
    Hs.386748  [show with all ESTs]
    Unigene Representative Sequence: NM_000139
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524868 ENST00000440896(uc009ymu.3) ENST00000278888(uc001nop.3 uc021qka.1)

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    hsa-miR-579 hsa-miR-137 hsa-miR-25 hsa-miR-373* hsa-miR-27b* hsa-miR-15b* hsa-miR-520g hsa-miR-92b
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      QuantiFast Probe-based Assays in human, mouse, rat MS4A2

    Additional mRNA sequence: 

    AK304487.1 AK310142.1 BC074800.2 BC074843.2 D10583.1 JF411082.1 X66187.1 

    1 DOTS entry:

    DT.205822 

    12 AceView cDNA sequences:

    BC074843 BC074800 D10583 BV198931 BF854137 NM_000139 X66187 CB053064 
    AA953113 AV742479 AI251003 AU186113 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MS4A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGACCACTG
    MS4A2 Expression
    About this image


    MS4A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     NULL (Uncategorized)
             Mast-like cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    MS4A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.386748

    UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Tissue specificity: Found on the surface of mast cells and basophils

        Pathway & Disease-focused RT2 Profiler PCR Array including MS4A2: 
              Allergy & Asthma in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MS4A2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ms4a21 , 5 membrane-spanning 4-domains, subfamily A, member 21, 5 76.05(n)1
    61.47(a)1
      19 (8.46 cM)5
    141261  NM_013516.21  NP_038544.11 
     116171935 


    ENSEMBL Gene Tree for MS4A2 (if available)
    TreeFam Gene Tree for MS4A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MS4A2 gene
    MS4A32  
    1 SIMAP similar gene for MS4A2 using alignment to 2 protein entries:     FCERB_HUMAN (see all proteins):
    FceRI

    Find genes that share paralogs with MS4A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    FCERB_HUMAN, Q01362: Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample
    in Australia. It seems to be a risk factor for atopic dermatitis and asthma


    Selected SNPs for MS4A2 (see all 313)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5691081,2,,4
    C,F,Hother159783749(-) ACATTT/CCCCCT 2 /E /G mis1 ese326Minor allele frequency- C:0.11MN NS EA NA WA EU 10321
    rs1115528621,2
    F--56208463(+) TGTGTG/ATATGT 1 -- int11Minor allele frequency- A:0.50CSA 4
    rs57921681,2
    C--56210652(+) TAGGGT/-TTTTT 1 -- ut31 trp32Minor allele frequency- -:0.00NA 4
    rs569495801,2
    C--59774813(+) ACCCTA/GTCTCT 1 -- us2k10--------
    rs1439817431,2
    C--59774921(+) GAGTT-/TGCGGTGA 1 -- us2k10--------
    rs107922551,2
    C,F,A,H--59774964(+) GGCAAT/CAAGAG 1 -- us2k15Minor allele frequency- C:0.25NA 12
    rs1840934911,2
    --59775042(+) AAATTC/TGTGGC 1 -- us2k10--------
    rs1404844141,2
    --59775053(+) TGGGCA/GCAGTG 1 -- us2k10--------
    rs1849013971,2
    --59775060(+) AGTGGC/TTCACT 1 -- us2k10--------
    rs1899059411,2
    --59775108(+) AGTCAC/TCTGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MS4A2 (59855734 - 59865940 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MS4A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468579CNV Gain19166990
    nsv832173CNV Gain17160897

    Human Gene Mutation Database (HGMD): MS4A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MS4A2
    DNA2.0 Custom Variant and Variant Library Synthesis for MS4A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147138   
    OMIM disorders: 147050  
    7 diseases for MS4A2:    
    About MalaCards
    hand dermatosis    allergic asthma    food allergy    atopy
    wegener's granulomatosis    type 1 diabetes mellitus    asthma

    6 diseases from the University of Copenhagen DISEASES database for MS4A2:
    Asthma     Hypersensitivity reaction type I disease     Rhinitis     Dermatitis
    Hand dermatosis     Bronchitis

    Find genes that share disorders with MS4A2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MS4A2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atopy 88.5 76 15788141 (9), 15087090 (6), 10550754 (5), 11071084 (5) (see all 28)
    dermatitis atopic 76.9 10 15788141 (3), 11101848 (2), 9521597 (1), 9856836 (1) (see all 5)
    asthma allergic 71.8 4 10810222 (4)
    asthma 67.6 22 16839402 (3), 17321582 (2), 19218813 (2), 10550754 (1) (see all 13)
    allergic rhinitis 61.6 3 11101848 (1), 9856836 (1), 15788141 (1)
    anaphylaxis 46.4 1 9856836 (1)
    asthma childhood 43.9 1 17178032 (1)
    allergy 41.5 2 11101848 (1), 12944417 (1)
    genetic susceptibility 41.2 5 8994858 (2), 9521597 (1), 8543789 (1)
    conjunctivitis 40.6 1 9856836 (1)

    Genetic Association Database (GAD): MS4A2
    Human Genome Epidemiology (HuGE) Navigator: MS4A2 (63 documents)

    Export disorders for MS4A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MS4A2 gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with MS4A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between atopic asthma and a coding variant of Fc-epsilon- RI-beta in a Japanese population. (PubMed id 8842731)1, 2, 4 Shirakawa T....Hopkin J. (Hum. Mol. Genet. 1996)
    2. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. (PubMed id 8817330)1, 2, 4 Hill M.R. and Cookson W.O. (Hum. Mol. Genet. 1996)
    3. Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor. (PubMed id 1386024)1, 2, 3 Maekawa K.... Harada S. (FEBS Lett. 1992)
    4. A polymorphism of MS4A2 (- 109T &gt; C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma. (PubMed id 16839402)1, 4, 9 Kim S.H....Park H.S. (Clin. Exp. Allergy 2006)
    5. A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. (PubMed id 20085599)1, 4, 9 Genuneit J....Moffatt M.F. (Clin. Exp. Allergy 2009)
    6. Promoter polymorphism in the MS4A2 gene and asthma in the Indian population. (PubMed id 19218813)1, 4, 9 Sharma S. and Ghosh B. (Int. Arch. Allergy Immunol. 2009)
    7. [Gene mutation of high affinity immunoglobulin E receptor beta-chain in children with asthma]. (PubMed id 17178032)1, 4, 9 Li M....Li B. (Zhongguo Dang Dai Er Ke Za Zhi 2006)
    8. Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness. (PubMed id 17430357)1, 4, 9 Kim Y.K....Kim Y.Y. (Clin. Exp. Allergy 2007)
    9. The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. (PubMed id 1535625)1, 2, 9 Kuester H.... Kinet J.-P. (J. Biol. Chem. 1992)
    10. Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)1, 4 Monroy C.M....El-Zein R.A. (Mol. Carcinog. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2206 HGNC: 7316 AceView: MS4A2 Ensembl:ENSG00000149534 euGenes: HUgn2206
    ECgene: MS4A2 Kegg: 2206 H-InvDB: MS4A2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MS4A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MS4A2 gene:
    Search GeneIP for patents involving MS4A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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