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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MS4A2 Gene

protein-coding   GIFtS: 64
GCID: GC11P059856

Membrane-Spanning 4-Domains, Subfamily A, Member 2

(Previous names: IgE responsiveness (atopic), membrane-spanning 4-domains,...)
(Previous symbols: FCER1B, IGER, APY)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 21 2     IGEL2
FCER1B1 2 3 5     IGHER2
APY1 2 3     MS4A12
IGER1 2 3     Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide2
IgE Fc Receptor Subunit Beta2 3     High Affinity IgE Receptor Beta Subunit2
Fc Fragment Of IgE1     High Affinity Immunoglobulin Epsilon Receptor Beta-Subunit (FcERI) (IgE Fc
Receptor, Beta-Subunit) (Fc Epsilon Receptor I Beta-Chain)2
High Affinity I1     High Affinity Immunoglobulin Epsilon Receptor Subunit Beta2
IgE Responsiveness (Atopic)1     Immunoglobulin E Receptor, High Affinity, Beta Polypeptide2
Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment Of IgE,
High Affinity I, Receptor For; Beta Polypeptide)1
     FcERI3
Receptor For; Beta Polypeptide1     Fc Epsilon Receptor I Beta-Chain3
ATOPY2     Membrane-Spanning 4-Domains Subfamily A Member 23
FCERI2     

External Ids:    HGNC: 73161   Entrez Gene: 22062   Ensembl: ENSG000001495347   OMIM: 1471385   UniProtKB: Q013623   

Export aliases for MS4A2 gene to outside databases

Previous GC identifers: GC11P062251 GC11P061369 GC11P060107 GC11P059631 GC11P059612 GC11P056203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MS4A2 Gene:
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the
release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an
alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene
encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene
family. Members of this nascent protein family are characterized by common structural features and similar
intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid
tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members.
Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript
variants have been described but require experimental validation. (provided by RefSeq, Mar 2012)

GeneCards Summary for MS4A2 Gene: 
MS4A2 (membrane-spanning 4-domains, subfamily A, member 2) is a protein-coding gene. Diseases associated with MS4A2 include hand dermatosis, and alexia, and among its related super-pathways are Immune response BCR pathway and Role of LAT2/NTAL/LAB on calcium mobilization. GO annotations related to this gene include SH2 domain binding and protein kinase binding. An important paralog of this gene is MS4A3.

UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by
multivalent antigens is required for the full mast cell response, including the release of preformed mediators
(such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the
secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the
release of mediators responsible for the manifestations of allergy

Gene Wiki entry for MS4A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MS4A2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MS4A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12-q13

MS4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059856:  view genomic region     (about GC identifiers)

Start:
59,855,734 bp from pter      End:
59,865,940 bp from pter
Size:
10,207 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362 (See protein sequence)
Recommended Name: High affinity immunoglobulin epsilon receptor subunit beta  
Size: 244 amino acids; 26534 Da
Subunit: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts
with FGR, FES/FPS and LYN (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q54A81

Explore the universe of human proteins at neXtProt for MS4A2: NX_Q01362

Explore proteomics data for MS4A2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues by LYN (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01362

  • MS4A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MS4A2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000130.1  NP_001243845.1  

    ENSEMBL proteins: 
     ENSP00000433311   ENSP00000278888  
    Reactome Protein details: Q01362
    Human Recombinant Protein Products for MS4A2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MS4A2 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane ----

    MS4A2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry Q01362

    ProtoNet protein and cluster: Q01362

    1 Blocks protein domain: IPB007237 CD20/IgE Fc receptor beta subunit

    UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Similarity: Belongs to the MS4A family


    MS4A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCERB_HUMAN, Q01362
    Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by
    multivalent antigens is required for the full mast cell response, including the release of preformed mediators
    (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the
    secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the
    release of mediators responsible for the manifestations of allergy

         Genatlas biochemistry entry for MS4A2:
    membrane-spanning 4-domains, subfamily A, member 2,cell differentiation antigen CD20 (gp35),37/35kDa,identified by
    monoclonal antibodies B1,1F5

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005262calcium channel activity TAS9169438
    GO:0019863IgE binding IEA--
    GO:0019901protein kinase binding IEA--
    GO:0042169SH2 domain binding IEA--
    GO:0051219phosphoprotein binding IEA--
         
    MS4A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MS4A2:
     Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ms4a2):
     immune system 

    MS4A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MS4A2: Ms4a2tm1Knt Ms4a2tm1Chr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MS4A2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MS4A2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MS4A2 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMS4A2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MS4A2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Fc-epsilon receptor I signaling in mast cells0.33
    Fc epsilon RI signaling pathway0.40
    2Fc epsilon receptor (FCERI) signaling
    Fc epsilon receptor (FCERI) signaling0.69
    Role of LAT2/NTAL/LAB on calcium mobilization0.69
    3FCERI mediated Ca+2 mobilization
    FCERI mediated Ca+2 mobilization0.60
    FCERI mediated MAPK activation0.60
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    5Immune response NFAT in immune response
    Immune response NFAT in immune response0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for MS4A2
        Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway


    2 GeneGo (Thomson Reuters) Pathways for MS4A2
        Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    1 BioSystems Pathway for MS4A2
        Fc-epsilon receptor I signaling in mast cells


    5/7        Reactome Pathways for MS4A2 (see all 7)
        FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    Fc epsilon receptor (FCERI) signaling
    Role of LAT2/NTAL/LAB on calcium mobilization
    FCERI mediated Ca+2 mobilization


    2         Kegg Pathways  (Kegg details for MS4A2):
        Fc epsilon RI signaling pathway
    Asthma


    MS4A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MS4A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for MS4A2 (Q013623 ENSP000002788884) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434053, ENSP000003648984I2D: score=2 STRING: ENSP00000364898
    PRKCDQ056553, ENSP000003316024I2D: score=1 STRING: ENSP00000331602
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006959humoral immune response TAS2448768
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS9169438

    MS4A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MS4A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MS4A2 (FCERB)

    1 DrugBank Compound for MS4A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Omalizumab-- 242138-07-4targetantagonist17016423 17139284 17073688

    1 Novoseek inferred chemical compound relationship for MS4A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergens 59.6 5 15788141 (3), 11101848 (1), 1741930 (1)

    1 PharmGKB related drug/compound annotation for MS4A2 gene    About this table
    Drug/compound PharmGKB Annotation
    tositumomab

    Search CenterWatch for drugs/clinical trials and news about MS4A2 / FCERB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MS4A2 gene (3 alternative transcripts): 
    NM_000139.4  NM_001256916.1  NM_001142303.1  

    Unigene Cluster for MS4A2:

    Membrane-spanning 4-domains, subfamily A, member 2
    Hs.386748  [show with all ESTs]
    Unigene Representative Sequence: NM_000139
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524868 ENST00000440896(uc009ymu.3) ENST00000278888(uc001nop.3 uc021qka.1)

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    hsa-miR-579 hsa-miR-137 hsa-miR-25 hsa-miR-373* hsa-miR-27b* hsa-miR-15b* hsa-miR-520g hsa-miR-92b
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    Additional mRNA sequence: 

    AK304487.1 AK310142.1 BC074800.2 BC074843.2 D10583.1 JF411082.1 X66187.1 

    1 DOTS entry:

    DT.205822 

    12 AceView cDNA sequences:

    BC074800 BC074843 D10583 BV198931 NM_000139 BF854137 X66187 CB053064 
    AA953113 AI251003 AV742479 AU186113 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MS4A2 expression in normal human tissues (normalized intensities)      MS4A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGACCACTG
    MS4A2 Expression
    About this image


    MS4A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             Mast-like cells ( Generation of hematopoietic progenitor cells and mast cells )
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles

    See MS4A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MS4A2

    SOURCE GeneReport for Unigene cluster: Hs.386748

    UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Tissue specificity: Found on the surface of mast cells and basophils

        SABiosciences Expression via Pathway-Focused PCR Array including MS4A2: 
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MS4A2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ms4a21 , 5 membrane-spanning 4-domains, subfamily A, member 21, 5 76.19(n)1
    61.47(a)1
      19 (8.46 cM)5
    141261  NM_013516.11  NP_038544.11 
     116171935 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    20(a)
    15(a)
    possible ortholog
    possible ortholog
    GL343276.1(314310-322731)
    GL343235.1(295317-310525)
    zebrafish
    (Danio rerio)
    Actinopterygii ms4a17a.146
    CU694374.36
    (see all 19)
    Uncharacterized protein
    (see all 19)
    21(a)
    19(a)
    (see all 19)
    many ↔ many
    many ↔ many
    (see all 19)
    4(60581972-60613219)
    4(60787636-60793140)


    ENSEMBL Gene Tree for MS4A2 (if available)
    TreeFam Gene Tree for MS4A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MS4A2 gene
    MS4A32  
    1 SIMAP similar gene for MS4A2 using alignment to 2 protein entries:     FCERB_HUMAN (see all proteins):
    FceRI

    MS4A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Polymorphism: Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample
    in Australia. It seems to be a risk factor for atopic dermatitis and asthma


    10/313 SNPs in MS4A2 are shown (see all 313)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5691081,2,4
    C,F,Hother159783749(-) ACATTT/CCCCCT 2 /E /G mis1 ese326Minor allele frequency- C:0.11MN NS EA NA WA EU 10321
    rs1115528621,2
    F--56208463(+) TGTGTG/ATATGT 1 -- int11Minor allele frequency- A:0.50CSA 4
    rs57921681,2
    C--56210652(+) TAGGGT/-TTTTT 1 -- ut31 trp32Minor allele frequency- -:0.00NA 4
    rs569495801,2
    C--59774813(+) ACCCTA/GTCTCT 1 -- us2k10--------
    rs1439817431,2
    C--59774921(+) GAGTT-/TGCGGTGA 1 -- us2k10--------
    rs107922551,2
    C,F,A,H--59774964(+) GGCAAT/CAAGAG 1 -- us2k15Minor allele frequency- C:0.25NA 12
    rs1840934911,2
    --59775042(+) AAATTC/TGTGGC 1 -- us2k10--------
    rs1404844141,2
    --59775053(+) TGGGCA/GCAGTG 1 -- us2k10--------
    rs1849013971,2
    --59775060(+) AGTGGC/TTCACT 1 -- us2k10--------
    rs1899059411,2
    --59775108(+) AGTCAC/TCTGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MS4A2 (59855734 - 59865940 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MS4A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv468579CNV Gain19166990
    nsv832173CNV Gain17160897


    Human Gene Mutation Database (HGMD): MS4A2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MS4A2
    DNA2.0 Custom Variant and Variant Library Synthesis for MS4A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147138   
    OMIM disorders: 147050  
    20/31 diseases for MS4A2 (see all 31):    About MalaCards
    hand dermatosis    alexia    food allergy    atopy
    allergic asthma    peripheral vascular disease    atopic dermatitis    wegener's granulomatosis
    eczema    cerebrovascular disease    allergic rhinitis    urticaria
    bronchitis    angioedema    rhinitis    rabies
    vascular disease    systemic lupus erythematosus    dermatitis    asthma

    6 diseases from the University of Copenhagen DISEASES database for MS4A2:
    Asthma     Hypersensitivity reaction type I disease     Rhinitis     Dermatitis
    Hand dermatosis     Bronchitis

    MS4A2 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for MS4A2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atopy 88.5 76 15788141 (9), 15087090 (6), 10550754 (5), 11071084 (5) (see all 28)
    dermatitis atopic 76.9 10 15788141 (3), 11101848 (2), 9521597 (1), 9856836 (1) (see all 5)
    asthma allergic 71.8 4 10810222 (4)
    asthma 67.6 22 16839402 (3), 17321582 (2), 19218813 (2), 10550754 (1) (see all 13)
    allergic rhinitis 61.6 3 11101848 (1), 9856836 (1), 15788141 (1)
    anaphylaxis 46.4 1 9856836 (1)
    asthma childhood 43.9 1 17178032 (1)
    allergy 41.5 2 11101848 (1), 12944417 (1)
    genetic susceptibility 41.2 5 8994858 (2), 9521597 (1), 8543789 (1)
    conjunctivitis 40.6 1 9856836 (1)

    Genetic Association Database (GAD): MS4A2
    Human Genome Epidemiology (HuGE) Navigator: MS4A2 (63 documents)

    Export disorders for MS4A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MS4A2 gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with MS4A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between atopic asthma and a coding variant of Fc-epsilon- RI-beta in a Japanese population. (PubMed id 8842731)1, 2, 4 Shirakawa T....Hopkin J. (1996)
    2. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. (PubMed id 8817330)1, 2, 4 Hill M.R. and Cookson W.O. (1996)
    3. Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor. (PubMed id 1386024)1, 2, 3 Maekawa K.... Harada S. (1992)
    4. A polymorphism of MS4A2 (- 109T > C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma. (PubMed id 16839402)1, 4, 9 Kim S.H....Park H.S. (2006)
    5. A multi-centre study of candidate genes for wheeze an d allergy: the International Study of Asthma and Allergies in Childhood Phase 2 . (PubMed id 20085599)1, 4, 9 Genuneit J....Moffatt M.F. (2009)
    6. Promoter Polymorphism in the MS4A2 Gene and Asthma in the Indian Population. (PubMed id 19218813)1, 4, 9 Sharma S. and Ghosh B. (2009)
    7. [Gene mutation of high affinity immunoglobulin E receptor beta-chain in children with asthma] (PubMed id 17178032)1, 4, 9 Li M....Li B. (2006)
    8. Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness. (PubMed id 17430357)1, 4, 9 Kim Y.K....Kim Y.Y. (2007)
    9. The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. (PubMed id 1535625)1, 2, 9 Kuester H.... Kinet J.-P. (1992)
    10. Hodgkin disease risk: Role of genetic polymorphisms a nd gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)1, 4 Monroy C.M....El-Zein R.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2206 HGNC: 7316 AceView: MS4A2 Ensembl:ENSG00000149534 euGenes: HUgn2206
    ECgene: MS4A2 Kegg: 2206 H-InvDB: MS4A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MS4A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MS4A2 gene:
    Search GeneIP for patents involving MS4A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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