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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MS4A2 Gene

protein-coding   GIFtS: 62
GCID: GC11P059856

membrane-spanning 4-domains, subfamily A, member 2

(Previous names: IgE responsiveness (atopic), membrane-spanning 4-domains,...)
(Previous symbols: FCER1B, IGER, APY)
 Explore 31 diseases affiliated with
MS4A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MS4A2    

Aliases
for MS4A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 21 2     IGEL2
FCER1B1 2 3 5     IGHER2
APY1 2 3     Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide2
IGER1 2 3     High Affinity IgE Receptor Beta Subunit2
MS4A11 2     High Affinity Immunoglobulin Epsilon Receptor Beta-Subunit (FcERI) (IgE Fc
Receptor, Beta-Subunit) (Fc Epsilon Receptor I Beta-Chain)2
IgE Fc Receptor Subunit Beta2 3     High Affinity Immunoglobulin Epsilon Receptor Subunit Beta2
IgE Responsiveness (Atopic)1     Immunoglobulin E Receptor, High Affinity, Beta Polypeptide2
Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment Of IgE, High
Affinity I, Receptor For; Beta Polypeptide)1
     FcERI3
ATOPY2     Fc Epsilon Receptor I Beta-Chain3
FCERI2     Membrane-Spanning 4-Domains Subfamily A Member 23

External Ids:    HGNC: 73161   Entrez Gene: 22062   Ensembl: ENSG000001495347   OMIM: 1471385   UniProtKB: Q013623   

Export aliases for MS4A2 gene to outside databases

Previous GC identifers: GC11P062251 GC11P061369 GC11P060107 GC11P059631 GC11P059612 GC11P056203


Summaries
for MS4A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MS4A2:
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the
release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha,
beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the
beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of
this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries
and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is
localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in
multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but
require experimental validation. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by
multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such
as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of
important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators
responsible for the manifestations of allergy

Gene Wiki entry for MS4A2


Genomic Views
for MS4A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MS4A2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MS4A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MS4A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12-q13

MS4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059856:  view genomic region     (about GC identifiers)

Start:
 59,855,734 bp from pter      End:
 59,865,940 bp from pter
Size:
 10,207 bases      Orientation:
 plus strand

Proteins
for MS4A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362 (See protein sequence)
Recommended Name: High affinity immunoglobulin epsilon receptor subunit beta  
Size: 244 amino acids; 26534 Da
Subunit: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Binds LILRB1. Interacts with
FGR, FES/FPS and LYN (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q54A81

Explore the universe of human proteins at neXtProt for MS4A2: NX_Q01362

Post-translational modifications:

  • Phosphorylated on tyrosine residues by LYN (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01362

    • MS4A2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000130.1  NP_001243845.1  

    ENSEMBL proteins: 
     ENSP00000433311   ENSP00000278888  

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    Novus Biologicals MS4A2 Proteins
    Novus Biologicals MS4A2 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MS4A2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0032998Fc-epsilon receptor I complex IEA--
    GO:0045121membrane raft IEA--


    MS4A2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MS4A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MS4A2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry Q01362

    ProtoNet protein and cluster: Q01362

    1 Blocks protein family: IPB007237 CD20/IgE Fc receptor beta subunit

    UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Similarity: Belongs to the MS4A family


    Function
    for MS4A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by
    multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such
    as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of
    important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators
    responsible for the manifestations of allergy

         Genatlas biochemistry entry for MS4A2:
    membrane-spanning 4-domains, subfamily A, member 2,cell differentiation antigen CD20 (gp35),37/35kDa,identified by
    monoclonal antibodies B1,1F5

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MS4A2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate MS4A2 (see all 18):
    hsa-miR-579 hsa-miR-137 hsa-miR-25 hsa-miR-373* hsa-miR-27b* hsa-miR-15b* hsa-miR-520g hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: MS4A2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MS4A2 (see all 7)
    OriGene shRNA RFP: MS4A2
    OriGene siRNA: MS4A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MS4A2

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005262calcium channel activity TAS9169438
    GO:0019767IgE receptor activity ----
    GO:0019863IgE binding IEA--
    GO:0019901protein kinase binding IEA--
    GO:0042169SH2 domain binding IEA--


    MS4A2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MS4A2:
     Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-outs for MS4A2: Ms4a2tm1Knt Ms4a2tm1Chr
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Ms4a2):
     immune system 

    MS4A2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MS4A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response Fc epsilon RI pathway
    		Immune response Fc epsilon RI pathway1.00
    		Fc-epsilon receptor I signaling in mast cells0.33
    		Immune response_Fc epsilon RI pathway0.99
    2Immune response_NFAT in immune response
    		Immune response_NFAT in immune response1.00
    		Immune response NFAT in immune response0.91
    3Allograft rejection
    		Asthma0.44
    4VEGF signaling pathway
    		Fc epsilon RI signaling pathway0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for MS4A2
        Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway


    2 GeneGo (Thomson Reuters) Pathways for MS4A2
        Immune response Fc epsilon RI pathway
    Immune response NFAT in immune response

    1 BioSystems Pathway for MS4A2 
        Fc-epsilon receptor I signaling in mast cells


    2         Kegg Pathways  (Kegg details for MS4A2):
        Fc epsilon RI signaling pathway
    Asthma


    MS4A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MS4A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for MS4A2 (Q013623 ENSP000002788884) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434053, ENSP000003648984I2D: score=2 STRING: ENSP00000364898
    PRKCDQ056553, ENSP000003316024I2D: score=1 STRING: ENSP00000331602
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006959humoral immune response TAS2448768
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS9169438


    MS4A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MS4A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MS4A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MS4A2

    1 DrugBank Compound for MS4A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Omalizumab-- 242138-07-4targetantagonist17016423 17139284 17073688

    1 Novoseek chemical compound relationship for MS4A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergens 59.6 5 15788141 (3), 11101848 (1), 1741930 (1)

    1 PharmGKB related drug/compound annotation for MS4A2 gene
    Drug/compound PharmGKB Annotation
    tositumomabDL  
    About this table

    Search CenterWatch for drugs/clinical trials and news about MS4A2 / FCERB 

    Transcripts
    for MS4A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MS4A2 gene (3 alternative transcripts): 
    NM_000139.4  NM_001256916.1  NM_001142303.1  

    Unigene Cluster for MS4A2:

    Membrane-spanning 4-domains, subfamily A, member 2
    Hs.386748  [show with all ESTs]
    Unigene Representative Sequence: NM_000139
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524868 ENST00000440896(uc009ymu.3) ENST00000278888(uc001nop.3 uc021qka.1)


    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate MS4A2 (see all 18):
    hsa-miR-579 hsa-miR-137 hsa-miR-25 hsa-miR-373* hsa-miR-27b* hsa-miR-15b* hsa-miR-520g hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: MS4A2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MS4A2 (see all 7)
    OriGene shRNA RFP: MS4A2
    OriGene siRNA: MS4A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MS4A2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK304487.1 AK310142.1 BC074800.2 BC074843.2 D10583.1 JF411082.1 X66187.1 

    1 DOTS entry:

    DT.205822 

    12 AceView cDNA sequences:

    D10583 BC074843 BC074800 BV198931 BF854137 NM_000139 X66187 AA953113 
    CB053064 AU186113 AV742479 AI251003 

    GeneLoc Exon Structure


    Expression
    for MS4A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MS4A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGACCACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MS4A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyGlomerulusKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mast-like cells (Generation of hemato...)

    See MS4A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MS4A2

    SOURCE GeneReport for Unigene cluster: Hs.386748

    UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Tissue specificity: Found on the surface of mast cells and basophils

        SABiosciences Expression via Pathway-Focused PCR Array including MS4A2: 
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A2

    Orthologs
    for MS4A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MS4A2 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 19(a)
    		 possible ortholog
    		 GL343276.1(317710-322731)
    zebrafish
    (Danio rerio)    		 Actinopterygii ms4a17a.146
    ms4a17a.16
    (see all 19)    		 membrane-spanning 4-domains, subfamily A, member 1...
    membrane-spanning 4-domains, subfamily A, member 1...
    (see all 19)    		 22(a)
    20(a)
    (see all 19)    		 many ↔ many
    many ↔ many
    (see all 19)    		 4(60581972-60613219)
    4(60713149-60743387)


    ENSEMBL Gene Tree for MS4A2 (if available)
    TreeFam Gene Tree for MS4A2 (if available) 

    Paralogs
    for MS4A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MS4A2 gene
    MS4A182  MS4A8B2  MS4A4A2  MS4A122  MS4A152  MS4A32  
    1 SIMAP similar gene for MS4A2 using alignment to 2 protein entries:     FCERB_HUMAN (see all proteins):
    FceRI

    MS4A2 for paralogs           About GeneDecksing



    Genomic Variants
    for MS4A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FCERB_HUMAN, Q01362
    Polymorphism: Variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in
    Australia. It seems to be a risk factor for atopic dermatitis and asthma


    10/255 NCBI SNPs in MS4A2 are shown (see all 255)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs5691081,2
    		C,F,H,other56210258(-) ACATTT/CCCCCT 2 /E /G mis1 ese326Minor allele frequency- C:0.11MN NS EA NA WA EU 10321
    rs778342791,2
    		C,--56201890(+) CTGCTC/TTCAAA 1 -- us2k12Minor allele frequency- T:0.06NA 122
    rs178604411,2
    		C,--56202245(+) AACTTA/GGNNNN 1 -- us2k14Minor allele frequency- G:0.08WA CSA NA 242
    rs734790871,2
    		C,--56203114(+) GTCTCA/GGGCAA 1 -- us2k12Minor allele frequency- G:0.03WA 120
    rs1133248351,2
    		F--56203361(+) ATATTC/ATTTAT 1 -- ut512Minor allele frequency- A:0.50CSA 4
    rs1116614211,2
    		F--56203871(+) AAATAG/TTAATA 1 -- int11Minor allele frequency- T:0.50CSA 4
    rs122939001,2
    		C,F,H,--56204094(+) GGCATG/AGATTT 1 -- int15Minor allele frequency- A:0.01NS EA WA 532
    rs178604501,2
    		--56204534(+) ACTTGA/GATTCA 1 -- int10--------
    rs1123800291,2
    		F--56204543(+) CATGAG/AAGGTG 1 -- int11Minor allele frequency- A:0.50CSA 4
    rs71274801,2
    		C,--56204702(+) AGATGG/TAAAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MS4A2 (59855734 - 59865940 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MS4A2: --
    Human Gene Mutation Database (HGMD): MS4A2

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MS4A2

    Disorders / Diseases
    for MS4A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MS4A2 for disorders           About GeneDecksing

    OMIM gene information: 147138   
    OMIM disorders: 147050  
    20/31 diseases for MS4A2 (see all 31):    About MalaCards
    hand dermatosis    systemic lupus erythematosus    allergic rhinitis    food allergy
    wegener's granulomatosis    systemic lupus erythematosus, association with    lupus erythematosus    atopy
    peripheral vascular disease    alexia    asthma    bronchial asthma
    atopic dermatitis    rhinitis    urticaria    acute lymphoblastic leukemia
    lymphoblastic leukemia    allergic asthma    angioedema    dermatitis

    6 diseases from the University of Copenhagen DISEASES database for MS4A2:
    Asthma     Hypersensitivity reaction type I disease     Rhinitis     Dermatitis
    Hand dermatosis     Bronchitis

    10/11 Novoseek disease relationships for MS4A2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atopy 88.5 76 15788141 (9), 15087090 (6), 10550754 (5), 11071084 (5) (see all 28)
    dermatitis atopic 76.9 10 15788141 (3), 11101848 (2), 9521597 (1), 9856836 (1) (see all 5)
    asthma allergic 71.8 4 10810222 (4)
    asthma 67.6 22 16839402 (3), 17321582 (2), 19218813 (2), 10550754 (1) (see all 13)
    allergic rhinitis 61.6 3 11101848 (1), 9856836 (1), 15788141 (1)
    anaphylaxis 46.4 1 9856836 (1)
    asthma childhood 43.9 1 17178032 (1)
    allergy 41.5 2 11101848 (1), 12944417 (1)
    genetic susceptibility 41.2 5 8994858 (2), 9521597 (1), 8543789 (1)
    conjunctivitis 40.6 1 9856836 (1)

    Genetic Association Database (GAD): MS4A2
    Human Genome Epidemiology (HuGE) Navigator: MS4A2 (63 documents)

    Export disorders for MS4A2 gene to outside databases

    Publications
    for MS4A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MS4A2 gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with MS4A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between atopic asthma and a coding variant of Fc-epsilon- RI-beta in a Japanese population. (PubMed id 8842731)1, 2, 4 Shirakawa T....Hopkin J. (1996)
    2. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. (PubMed id 8817330)1, 2, 4 Hill M.R. and Cookson W.O. (1996)
    3. Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor. (PubMed id 1386024)1, 2, 3 Maekawa K.... Harada S. (1992)
    4. The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. (PubMed id 1535625)1, 2, 9 Kuester H.... Kinet J.-P. (1992)
    5. Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. (PubMed id 15953854)1, 4 Choi J.H....Park H.S. (2005)
    6. A_16_C haplotype in the FcepsilonRIbeta gene confers a higher risk for atopic asthma in the Indian population. (PubMed id 15479187)1, 4 Sharma S....Ghosh B. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Associations between polymorphisms of the high-affinity immunoglobulin E receptor and late-onset airflow obstruction in older populations. (PubMed id 12919239)1, 4 Ruse C.E....Parker S.G. (2003)
    9. The association analysis of FcepsilonRIbeta with allergic asthma in a Chinese population. (PubMed id 14687477)1, 4 Cui T....Xie J. (2003)
    10. [Study on the high-affinity IgE receptor beta gene polymorphism and its association with the susceptibility to allergic asthma in Han nationality of Hubei province] (PubMed id 12903039)1, 4 Cui T.P....Wu J.M. (2003)

    External Searches for MS4A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing MS4A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2206 HGNC: 7316 AceView: MS4A2 Ensembl:ENSG00000149534 euGenes: HUgn2206
    ECgene: MS4A2 Kegg: 2206 H-InvDB: MS4A2

    Other Databases showing MS4A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MS4A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MS4A2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MS4A2 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MS4A2 gene:
    Search GeneIP for patents involving MS4A2

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