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Aliases for MS4A18 Gene

Aliases for MS4A18 Gene

  • Membrane Spanning 4-Domains A18 2 3
  • Membrane-Spanning 4-Domains, Subfamily A, Member 18 2 5

External Ids for MS4A18 Gene

Previous GeneCards Identifiers for MS4A18 Gene

  • GC11P060246
  • GC11P060489

Summaries for MS4A18 Gene

GeneCards Summary for MS4A18 Gene

MS4A18 (Membrane Spanning 4-Domains A18) is a Protein Coding gene. An important paralog of this gene is MS4A8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A18 Gene

Genomics for MS4A18 Gene

Regulatory Elements for MS4A18 Gene

Enhancers for MS4A18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MS4A18 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A18 Gene

60,724,009 bp from pter
60,744,213 bp from pter
20,205 bases
Plus strand

Genomic View for MS4A18 Gene

Genes around MS4A18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A18 Gene

Proteins for MS4A18 Gene

  • Protein details for MS4A18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 18
    Protein Accession:

    Protein attributes for MS4A18 Gene

    323 amino acids
    Molecular mass:
    34465 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A18 Gene

Proteomics data for MS4A18 Gene at MOPED

Post-translational modifications for MS4A18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MS4A18 Gene

Domains & Families for MS4A18 Gene

Gene Families for MS4A18 Gene

Protein Domains for MS4A18 Gene


Suggested Antigen Peptide Sequences for MS4A18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A18: view

Function for MS4A18 Gene

Phenotypes for MS4A18 Gene

GenomeRNAi human phenotypes for MS4A18:
genes like me logo Genes that share phenotypes with MS4A18: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MS4A18 Gene

Localization for MS4A18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MS4A18 Gene COMPARTMENTS Subcellular localization image for MS4A18 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MS4A18 Gene

Pathways & Interactions for MS4A18 Gene

SuperPathways for MS4A18 Gene

No Data Available

Interacting Proteins for MS4A18 Gene

Gene Ontology (GO) - Biological Process for MS4A18 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A18 Gene

Drugs & Compounds for MS4A18 Gene

No Compound Related Data Available

Transcripts for MS4A18 Gene

mRNA/cDNA for MS4A18 Gene

(7) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A18 Gene

Membrane-spanning 4-domains, subfamily A, member 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A18 Gene

No ASD Table

Relevant External Links for MS4A18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A18 Gene

mRNA expression in normal human tissues for MS4A18 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A18 Gene

This gene is overexpressed in Testis (x33.5) and Small Intestine - Terminal Ileum (x13.5).

Protein differential expression in normal tissues from HIPED for MS4A18 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A18 Gene

SOURCE GeneReport for Unigene cluster for MS4A18 Gene Hs.739039

genes like me logo Genes that share expression patterns with MS4A18: view

Protein tissue co-expression partners for MS4A18 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MS4A18 Gene

Orthologs for MS4A18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MS4A18 36
  • 53 (a)
(Canis familiaris)
Mammalia -- 36
  • 24 (a)
(Mus musculus)
Mammalia Ms4a18 36
  • 51 (a)
(Pan troglodytes)
Mammalia MS4A18 36
  • 98 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
-- 36
  • 30 (a)
-- 36
  • 22 (a)
(Danio rerio)
Actinopterygii FP015791.1 36
  • 26 (a)
ms4a17a.1 36
  • 24 (a)
ms4a17a.10 36
  • 24 (a)
ms4a17a.11 36
  • 26 (a)
ms4a17a.14 36
  • 29 (a)
ms4a17a.17 36
  • 20 (a)
ms4a17a.2 36
  • 23 (a)
ms4a17a.3 36
  • 24 (a)
ms4a17a.4 36
  • 23 (a)
ms4a17a.5 36
  • 25 (a)
ms4a17a.6 36
  • 26 (a)
ms4a17a.7 36
  • 22 (a)
ms4a17a.8 36
  • 20 (a)
ms4a17a.9 36
  • 21 (a)
ms4a17c.1 36
  • 21 (a)
ms4a17c.2 36
  • 21 (a)
si:ch73-56d11.3 36
  • 23 (a)
si:ch73-56d11.4 36
  • 23 (a)
si:dkey-174k12.3 36
  • 21 (a)
si:dkey-238j22.1 36
  • 20 (a)
si:dkey-77f5.10 36
  • 24 (a)
Species with no ortholog for MS4A18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A18 Gene

Gene Tree for MS4A18 (if available)
Gene Tree for MS4A18 (if available)

Paralogs for MS4A18 Gene

Paralogs for MS4A18 Gene

(2) SIMAP similar genes for MS4A18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MS4A18: view

Variants for MS4A18 Gene

Sequence variations from dbSNP and Humsavar for MS4A18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs529728 -- 60,738,642(-) ttgta(A/G)agatt intron-variant
rs612342 -- 60,727,651(+) GCACA(C/T)GTTAT intron-variant
rs725277 -- 60,741,425(+) AGGGA(C/T)CTTCA intron-variant
rs725278 -- 60,741,469(+) CATCC(C/T)CCAGT intron-variant
rs725279 -- 60,741,526(+) AAGAC(A/T)CAGCA intron-variant

Variation tolerance for MS4A18 Gene

Gene Damage Index Score: 1.65; 31.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MS4A18 Gene

Disorders for MS4A18 Gene

Relevant External Links for MS4A18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A18 Gene

Publications for MS4A18 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 67

Products for MS4A18 Gene

Sources for MS4A18 Gene