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Aliases for MS4A18 Gene

Aliases for MS4A18 Gene

  • Membrane Spanning 4-Domains A18 2 3
  • Membrane-Spanning 4-Domains, Subfamily A, Member 18 2
  • Membrane-Spanning 4-Domains Subfamily A Member 18 5

External Ids for MS4A18 Gene

Previous GeneCards Identifiers for MS4A18 Gene

  • GC11P060246
  • GC11P060489

Summaries for MS4A18 Gene

GeneCards Summary for MS4A18 Gene

MS4A18 (Membrane Spanning 4-Domains A18) is a Protein Coding gene. An important paralog of this gene is MS4A8.

Additional gene information for MS4A18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A18 Gene

Genomics for MS4A18 Gene

GeneHancer (GH) Regulatory Elements for MS4A18 Gene

Promoters and enhancers for MS4A18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I060950 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 9.2 +228.5 228487 4.9 HDGF PKNOX1 SMAD1 RB1 YBX1 BATF IRF4 YY1 ZNF207 ZNF143 SLC15A3 VPS37C RNU6-933P CPSF7 MS4A18 PTGDR2 PRPF19 MS4A2 CYB561A3 SDHAF2
GH11I060363 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -360.1 -360062 1.7 SMARCA5 CTCF ZNF654 ZBTB6 RB1 HLF MAX TRIM22 REST RAD21 MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A GC11P060374 GC11M060363
GH11I060366 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 9.4 -356.5 -356530 1.7 EBF1 KLF5 RELA NFATC1 ZNF143 ATF7 BCLAF1 IKZF2 RUNX3 SRF MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
GH11I060758 Promoter 0.8 EPDnew 11.4 +32.9 32922 0.1 CTCF MITF CBFB SMC3 RUNX3 RAD21 MS4A15 MS4A10 MS4A18 CCDC86 ENSG00000255959
GH11I060618 Enhancer 0.9 Ensembl ENCODE 9.9 -105.3 -105279 0.8 CTCF PKNOX1 RB1 RAD21 SMC3 ZNF143 ATF7 ETV6 ZNF444 FOS MS4A6E MS4A18 MS4A8 LINC00301 LOC105369321
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MS4A18 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MS4A18 Gene

Genomic Locations for MS4A18 Gene
20,205 bases
Plus strand

Genomic View for MS4A18 Gene

Genes around MS4A18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A18 Gene

Proteins for MS4A18 Gene

  • Protein details for MS4A18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 18
    Protein Accession:

    Protein attributes for MS4A18 Gene

    323 amino acids
    Molecular mass:
    34465 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A18 Gene

Post-translational modifications for MS4A18 Gene

No Post-translational modifications

Other Protein References for MS4A18 Gene

No data available for DME Specific Peptides for MS4A18 Gene

Domains & Families for MS4A18 Gene

Gene Families for MS4A18 Gene

Protein Domains for MS4A18 Gene


Suggested Antigen Peptide Sequences for MS4A18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A18: view

Function for MS4A18 Gene

Phenotypes From GWAS Catalog for MS4A18 Gene

Phenotypes for MS4A18 Gene

GenomeRNAi human phenotypes for MS4A18:
genes like me logo Genes that share phenotypes with MS4A18: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MS4A18 Gene

Localization for MS4A18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A18 gene
Compartment Confidence
extracellular 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MS4A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A18 Gene

Pathways & Interactions for MS4A18 Gene

SuperPathways for MS4A18 Gene

No Data Available

Interacting Proteins for MS4A18 Gene

Gene Ontology (GO) - Biological Process for MS4A18 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A18 Gene

Drugs & Compounds for MS4A18 Gene

No Compound Related Data Available

Transcripts for MS4A18 Gene

mRNA/cDNA for MS4A18 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A18 Gene

Membrane-spanning 4-domains, subfamily A, member 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A18 Gene

No ASD Table

Relevant External Links for MS4A18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A18 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A18 Gene

This gene is overexpressed in Testis (x33.5) and Small Intestine - Terminal Ileum (x13.5).

Protein differential expression in normal tissues from HIPED for MS4A18 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A18 Gene

Protein tissue co-expression partners for MS4A18 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A18 Gene:


SOURCE GeneReport for Unigene cluster for MS4A18 Gene:

genes like me logo Genes that share expression patterns with MS4A18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A18 Gene

Orthologs for MS4A18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A18 34
  • 98 (a)
(Bos Taurus)
Mammalia MS4A18 34
  • 53 (a)
(Mus musculus)
Mammalia Ms4a18 34
  • 51 (a)
(Canis familiaris)
Mammalia -- 34
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
-- 34
  • 27 (a)
-- 34
  • 22 (a)
(Danio rerio)
Actinopterygii ms4a17a.14 34
  • 29 (a)
FP015791.1 34
  • 26 (a)
ms4a17a.6 34
  • 26 (a)
ms4a17a.11 34
  • 26 (a)
ms4a17a.5 34
  • 25 (a)
ms4a17a.3 34
  • 24 (a)
ms4a17a.10 34
  • 24 (a)
ms4a17a.1 34
  • 24 (a)
si:dkey-77f5.10 34
  • 24 (a)
si:ch73-56d11.3 34
  • 23 (a)
si:ch73-56d11.4 34
  • 23 (a)
ms4a17a.4 34
  • 23 (a)
ms4a17a.2 34
  • 23 (a)
ms4a17a.7 34
  • 22 (a)
si:dkey-174k12.3 34
  • 21 (a)
ms4a17c.2 34
  • 21 (a)
ms4a17c.1 34
  • 21 (a)
ms4a17a.9 34
  • 21 (a)
si:dkey-238j22.1 34
  • 20 (a)
ms4a17a.8 34
  • 20 (a)
ms4a17a.17 34
  • 20 (a)
Species where no ortholog for MS4A18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A18 Gene

Gene Tree for MS4A18 (if available)
Gene Tree for MS4A18 (if available)

Paralogs for MS4A18 Gene

Paralogs for MS4A18 Gene

(2) SIMAP similar genes for MS4A18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MS4A18: view

Variants for MS4A18 Gene

Sequence variations from dbSNP and Humsavar for MS4A18 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000139779 -- 60,722,047(+) G/C upstream_transcript_variant
rs1000211111 -- 60,722,372(+) C/T upstream_transcript_variant
rs1000265892 -- 60,720,919(+) T/A upstream_transcript_variant
rs1000313650 -- 60,732,640(+) A/T intron_variant
rs1000360726 -- 60,732,749(+) A/C/G intron_variant

Variation tolerance for MS4A18 Gene

Gene Damage Index Score: 1.65; 31.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MS4A18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MS4A18 Gene

Disorders for MS4A18 Gene

Additional Disease Information for MS4A18

No disorders were found for MS4A18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A18 Gene

Publications for MS4A18 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58

Products for MS4A18 Gene

Sources for MS4A18 Gene

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