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Aliases for MS4A18 Gene

Aliases for MS4A18 Gene

  • Membrane Spanning 4-Domains A18 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 18 2

External Ids for MS4A18 Gene

Previous GeneCards Identifiers for MS4A18 Gene

  • GC11P060246
  • GC11P060489

Summaries for MS4A18 Gene

GeneCards Summary for MS4A18 Gene

MS4A18 (Membrane Spanning 4-Domains A18) is a Protein Coding gene. An important paralog of this gene is MS4A8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A18 Gene

Genomics for MS4A18 Gene

Regulatory Elements for MS4A18 Gene

Enhancers for MS4A18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F060756 0.2 ENCODE 11.3 +32.8 32774 0.2 CTCF CBFB SMC3 RAD21 MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A15
GH11F060759 0.6 Ensembl 11.3 +35.8 35792 0.8 ZNF316 RNF2 IKZF1 SPI1 MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A8 MS4A15
GH11F060761 0.6 ENCODE 11.3 +38.1 38129 1.2 HDGF SRF ELK1 EED IKZF1 STAT3 MS4A18 MS4A8 MS4A15 MS4A10
GH11F060683 0.5 ENCODE 10.8 -39.8 -39755 1.0 PKNOX1 MTA2 EBF1 TBX21 RAD51 IKZF1 MLLT1 SPI1 MS4A8 MS4A18 LOC105369321 LINC00301
GH11F060657 0.2 ENCODE 10.8 -65.5 -65470 1.3 CTCF ZBTB11 ZBTB33 ZBTB40 PPARG RAD21 GABPA YY1 MS4A18 LINC00301 LOC105369321
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MS4A18 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A18 Gene

Chromosome:
11
Start:
60,724,009 bp from pter
End:
60,744,213 bp from pter
Size:
20,205 bases
Orientation:
Plus strand

Genomic View for MS4A18 Gene

Genes around MS4A18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A18 Gene

Proteins for MS4A18 Gene

  • Protein details for MS4A18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3C1V0-M4A18_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 18
    Protein Accession:
    Q3C1V0

    Protein attributes for MS4A18 Gene

    Size:
    323 amino acids
    Molecular mass:
    34465 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A18 Gene

Post-translational modifications for MS4A18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A18 Gene

No data available for DME Specific Peptides for MS4A18 Gene

Domains & Families for MS4A18 Gene

Gene Families for MS4A18 Gene

Protein Domains for MS4A18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MS4A18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3C1V0

UniProtKB/Swiss-Prot:

M4A18_HUMAN :
  • Belongs to the MS4A family.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A18: view

Function for MS4A18 Gene

Phenotypes for MS4A18 Gene

GenomeRNAi human phenotypes for MS4A18:
genes like me logo Genes that share phenotypes with MS4A18: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MS4A18 Gene

Localization for MS4A18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A18 Gene COMPARTMENTS Subcellular localization image for MS4A18 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MS4A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A18: view

Pathways & Interactions for MS4A18 Gene

SuperPathways for MS4A18 Gene

No Data Available

Interacting Proteins for MS4A18 Gene

Gene Ontology (GO) - Biological Process for MS4A18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MS4A18 Gene

Transcripts for MS4A18 Gene

mRNA/cDNA for MS4A18 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A18 Gene

Membrane-spanning 4-domains, subfamily A, member 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A18 Gene

No ASD Table

Relevant External Links for MS4A18 Gene

GeneLoc Exon Structure for
MS4A18
ECgene alternative splicing isoforms for
MS4A18

Expression for MS4A18 Gene

mRNA expression in normal human tissues for MS4A18 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A18 Gene

This gene is overexpressed in Testis (x33.5) and Small Intestine - Terminal Ileum (x13.5).

Protein differential expression in normal tissues from HIPED for MS4A18 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A18 Gene



Protein tissue co-expression partners for MS4A18 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A18 Gene:

MS4A18

SOURCE GeneReport for Unigene cluster for MS4A18 Gene:

Hs.739039
genes like me logo Genes that share expression patterns with MS4A18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MS4A18 Gene

Orthologs for MS4A18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A18 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MS4A18 35
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ms4a18 35
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ms4a17a.14 35
  • 29 (a)
ManyToMany
FP015791.1 35
  • 26 (a)
ManyToMany
ms4a17a.11 35
  • 26 (a)
ManyToMany
ms4a17a.6 35
  • 26 (a)
ManyToMany
ms4a17a.5 35
  • 25 (a)
ManyToMany
ms4a17a.1 35
  • 24 (a)
ManyToMany
ms4a17a.10 35
  • 24 (a)
ManyToMany
ms4a17a.3 35
  • 24 (a)
ManyToMany
si:dkey-77f5.10 35
  • 24 (a)
ManyToMany
ms4a17a.2 35
  • 23 (a)
ManyToMany
ms4a17a.4 35
  • 23 (a)
ManyToMany
si:ch73-56d11.3 35
  • 23 (a)
ManyToMany
si:ch73-56d11.4 35
  • 23 (a)
ManyToMany
ms4a17a.7 35
  • 22 (a)
ManyToMany
ms4a17a.9 35
  • 21 (a)
ManyToMany
ms4a17c.1 35
  • 21 (a)
ManyToMany
ms4a17c.2 35
  • 21 (a)
ManyToMany
si:dkey-174k12.3 35
  • 21 (a)
ManyToMany
ms4a17a.17 35
  • 20 (a)
ManyToMany
ms4a17a.8 35
  • 20 (a)
ManyToMany
si:dkey-238j22.1 35
  • 20 (a)
ManyToMany
Species where no ortholog for MS4A18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A18 Gene

ENSEMBL:
Gene Tree for MS4A18 (if available)
TreeFam:
Gene Tree for MS4A18 (if available)

Paralogs for MS4A18 Gene

Paralogs for MS4A18 Gene

(2) SIMAP similar genes for MS4A18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MS4A18: view

Variants for MS4A18 Gene

Sequence variations from dbSNP and Humsavar for MS4A18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10459032 -- 60,738,996(+) TGTGA(C/T)GGTGA reference, missense
rs111323493 -- 60,723,336(+) TCAAC(A/G)TATCG upstream-variant-2KB, utr-variant-5-prime
rs111456691 -- 60,728,499(+) CTCTC(-/TCTG)TCTGT intron-variant
rs111481413 -- 60,742,054(+) GAAAT(C/T)CTATG intron-variant
rs111569703 -- 60,730,374(+) TGCCT(A/G)GCCAA intron-variant

Variation tolerance for MS4A18 Gene

Gene Damage Index Score: 1.65; 31.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MS4A18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MS4A18 Gene

Disorders for MS4A18 Gene

Relevant External Links for MS4A18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MS4A18

No disorders were found for MS4A18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A18 Gene

Publications for MS4A18 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for MS4A18 Gene

Sources for MS4A18 Gene

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