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Aliases for MS4A15 Gene

Aliases for MS4A15 Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 15 2 3

External Ids for MS4A15 Gene

Previous GeneCards Identifiers for MS4A15 Gene

  • GC00U915589
  • GC11P060280
  • GC11P060524
  • GC11P056871

Summaries for MS4A15 Gene

GeneCards Summary for MS4A15 Gene

MS4A15 (Membrane-Spanning 4-Domains, Subfamily A, Member 15) is a Protein Coding gene. An important paralog of this gene is MS4A18.

UniProtKB/Swiss-Prot for MS4A15 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A15 Gene

Genomics for MS4A15 Gene

Regulatory Elements for MS4A15 Gene

Genomic Location for MS4A15 Gene

60,756,867 bp from pter
60,776,733 bp from pter
19,867 bases
Plus strand

Genomic View for MS4A15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A15 Gene

Proteins for MS4A15 Gene

  • Protein details for MS4A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 15
    Protein Accession:
    Secondary Accessions:
    • A9UJY6
    • A9UJY7
    • F2Z2J5

    Protein attributes for MS4A15 Gene

    240 amino acids
    Molecular mass:
    25050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A15 Gene


neXtProt entry for MS4A15 Gene

Proteomics data for MS4A15 Gene at MOPED

Post-translational modifications for MS4A15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A15 Gene

No data available for DME Specific Peptides for MS4A15 Gene

Domains & Families for MS4A15 Gene

Gene Families for MS4A15 Gene

Protein Domains for MS4A15 Gene


Suggested Antigen Peptide Sequences for MS4A15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A15: view

Function for MS4A15 Gene

Molecular function for MS4A15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A15: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A15 Gene

Localization for MS4A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A15 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MS4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A15: view

No data available for Subcellular locations from COMPARTMENTS for MS4A15 Gene

Pathways & Interactions for MS4A15 Gene

SuperPathways for MS4A15 Gene

No Data Available

Interacting Proteins for MS4A15 Gene

Gene Ontology (GO) - Biological Process for MS4A15 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A15 Gene

Drugs & Compounds for MS4A15 Gene

No Compound Related Data Available

Transcripts for MS4A15 Gene

mRNA/cDNA for MS4A15 Gene

Unigene Clusters for MS4A15 Gene

Membrane-spanning 4-domains, subfamily A, member 15:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - - -
SP3: -

Relevant External Links for MS4A15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A15 Gene

mRNA expression in normal human tissues for MS4A15 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A15 Gene

This gene is overexpressed in Lung (x49.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A15 Gene

SOURCE GeneReport for Unigene cluster for MS4A15 Gene Hs.207465

genes like me logo Genes that share expression patterns with MS4A15: view

Protein tissue co-expression partners for MS4A15 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MS4A15 Gene

Orthologs for MS4A15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MS4A15 35
  • 87.09 (n)
  • 89.36 (a)
MS4A15 36
  • 87 (a)
(Canis familiaris)
Mammalia MS4A15 35
  • 81.76 (n)
  • 77.93 (a)
MS4A15 36
  • 72 (a)
(Mus musculus)
Mammalia Ms4a15 35
  • 83.56 (n)
  • 87.21 (a)
Ms4a15 16
Ms4a15 36
  • 78 (a)
(Pan troglodytes)
Mammalia MS4A15 35
  • 98.89 (n)
  • 98.75 (a)
MS4A15 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ms4a15 35
  • 83.41 (n)
  • 88.13 (a)
(Monodelphis domestica)
Mammalia MS4A15 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MS4A15 36
  • 70 (a)
(Gallus gallus)
Aves MS4A15 36
  • 34 (a)
(Anolis carolinensis)
Reptilia MS4A15 36
  • 28 (a)
(Danio rerio)
Actinopterygii FP015791.1 36
  • 27 (a)
ms4a17a.1 36
  • 24 (a)
ms4a17a.10 36
  • 25 (a)
ms4a17a.11 36
  • 27 (a)
ms4a17a.14 36
  • 28 (a)
ms4a17a.17 36
  • 20 (a)
ms4a17a.2 36
  • 24 (a)
ms4a17a.3 36
  • 25 (a)
ms4a17a.4 36
  • 24 (a)
ms4a17a.5 36
  • 25 (a)
ms4a17a.6 36
  • 26 (a)
ms4a17a.7 36
  • 26 (a)
ms4a17a.8 36
  • 26 (a)
ms4a17a.9 36
  • 25 (a)
ms4a17c.1 36
  • 23 (a)
ms4a17c.2 36
  • 20 (a)
si:ch73-56d11.3 36
  • 23 (a)
si:ch73-56d11.4 36
  • 25 (a)
si:dkey-174k12.3 36
  • 21 (a)
si:dkey-238j22.1 36
  • 22 (a)
si:dkey-77f5.10 36
  • 24 (a)
Species with no ortholog for MS4A15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A15 Gene

Gene Tree for MS4A15 (if available)
Gene Tree for MS4A15 (if available)

Paralogs for MS4A15 Gene

Paralogs for MS4A15 Gene

(2) SIMAP similar genes for MS4A15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MS4A15: view

Variants for MS4A15 Gene

Sequence variations from dbSNP and Humsavar for MS4A15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs511028 -- 60,774,276(+) agcca(C/T)gtgtg intron-variant
rs622823 -- 60,775,806(-) GATGG(G/T)GCTGG utr-variant-3-prime, nc-transcript-variant
rs1032939 - 60,763,873(-) CCCCC(A/C)GCGGT missense, reference, intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1395398 -- 60,765,250(-) GTACA(G/T)AAACA intron-variant
rs1818279 -- 60,761,784(-) CAACT(A/G)TGTCA intron-variant

Variation tolerance for MS4A15 Gene

Residual Variation Intolerance Score: 84.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.29; 92.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MS4A15 Gene

Disorders for MS4A15 Gene

Relevant External Links for MS4A15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MS4A15: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A15 Gene

Publications for MS4A15 Gene

  1. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 67
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for MS4A15 Gene

Sources for MS4A15 Gene

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