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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MS4A15 Gene

protein-coding   GIFtS: 41
GCID: GC11P060524

Membrane-Spanning 4-Domains, Subfamily A, Member 15

  Search for MS4A15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 151 2
Membrane-Spanning 4-Domains Subfamily A Member 152

External Ids:    HGNC: 285731   Entrez Gene: 2199952   Ensembl: ENSG000001669617   UniProtKB: Q8N5U13   

Export aliases for MS4A15 gene to outside databases

Previous GC identifers: GC00U915589 GC11P060280 GC11P056871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MS4A15 Gene: 
MS4A15 (membrane-spanning 4-domains, subfamily A, member 15) is a protein-coding gene. An important paralog of this gene is MS4A18.

UniProtKB/Swiss-Prot: M4A15_HUMAN, Q8N5U1
Function: May be involved in signal transduction as a component of a multimeric receptor complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MS4A15 gene promoter:
         COUP-TF1   AhR   Max1   NF-1   NF-1/L   STAT1   COUP   Arnt   COUP-TF   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A15 promoter sequence
   Search SABiosciences Chromatin IP Primers for MS4A15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

MS4A15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060524:  view genomic region     (about GC identifiers)

Start:
60,524,340 bp from pter      End:
60,544,205 bp from pter
Size:
19,866 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M4A15_HUMAN, Q8N5U1 (See protein sequence)
Recommended Name: Membrane-spanning 4-domains subfamily A member 15  
Size: 240 amino acids; 25050 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Alternative splicing: 2 isoforms:  Q8N5U1-1   Q8N5U1-2   

Explore the universe of human proteins at neXtProt for MS4A15: NX_Q8N5U1

Explore proteomics data for MS4A15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N5U1

  • MS4A15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MS4A15 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001092305.1  NP_001265171.1  NP_689930.1  

    ENSEMBL proteins: 
     ENSP00000434165   ENSP00000338692   ENSP00000413918   ENSP00000386022  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    MS4A15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry Q8N5U1

    ProtoNet protein and cluster: Q8N5U1

    UniProtKB/Swiss-Prot: M4A15_HUMAN, Q8N5U1
    Similarity: Belongs to the MS4A family


    MS4A15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4A15_HUMAN, Q8N5U1
    Function: May be involved in signal transduction as a component of a multimeric receptor complex (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for MS4A15:

     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MS4A15 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MS4A15

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MS4A15 (M4A15)

    Search CenterWatch for drugs/clinical trials and news about MS4A15 / M4A15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MS4A15 gene (3 alternative transcripts): 
    NM_001098835.1  NM_001278242.1  NM_152717.2  

    Unigene Cluster for MS4A15:

    Membrane-spanning 4-domains, subfamily A, member 15
    Hs.207465  [show with all ESTs]
    Unigene Representative Sequence: AK091846
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528170 ENST00000337911(uc001npx.2) ENST00000429322(uc001npy.2 uc009yng.1)
    ENST00000405633(uc009ynf.1)
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MS4A15:
    hsa-miR-539 hsa-miR-3175
    SwitchGear 3'UTR luciferase reporter plasmidMS4A15 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): MS4A15 (NM_001098835)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MS4A15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A15
    Sirion Biotech Customized lentivirus for stable overexpression of MS4A15 
                         Customized lentivirus expression plasmids for stable overexpression of MS4A15 
    Primer
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    OriGene qPCR primer pairs and template standards for MS4A15
    OriGene qSTAR qPCR primer pairs in human, mouse for MS4A15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MS4A15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A15

    Additional mRNA sequence: 

    AK091846.1 AK300233.1 AY584608.1 AY584609.1 BC031610.1 

    3 DOTS entries:

    DT.75167330  DT.100020760  DT.95258656 

    11 AceView cDNA sequences:

    AK091846 AX747218 BC031610 NM_152717 BM996493 CB044497 CB044496 AI797091 
    BI824549 BI818815 BX117401 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MS4A15    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -                                                   
    SP2:        -     -                 -                                 
    SP3:                                -                                 


    ECgene alternative splicing isoforms for MS4A15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MS4A15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MS4A15 Expression
    About this image


    See MS4A15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MS4A15

    SOURCE GeneReport for Unigene cluster: Hs.207465
        SABiosciences Custom PCR Arrays for MS4A15
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MS4A15 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ms4a151 , 5 membrane-spanning 4-domains, subfamily A, member 151, 5 82.73(n)1
    86.04(a)1
      19 (7.47 cM)5
    5452791  NM_001034898.21  NP_001030070.11 
     109783075 
    chicken
    (Gallus gallus)
    Aves MS4A156
    membrane-spanning 4-domains, subfamily A, member 1...
    32(a)
    1 ↔ 1
    5(476599-482298)
    lizard
    (Anolis carolinensis)
    Reptilia MS4A156
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    28(a)
    25(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    GL343235.1(85064-109424)
    GL343276.1(314310-322731)
    zebrafish
    (Danio rerio)
    Actinopterygii ms4a17a.146
    ms4a17a.76
    (see all 19)
    membrane-spanning 4-domains, subfamily A, member 1...
    membrane-spanning 4-domains, subfamily A, member 1...
    (see all 19)
    27(a)
    24(a)
    (see all 19)
    many ↔ many
    many ↔ many
    (see all 19)
    4(60581972-60613219)
    4(60747967-60760458)


    ENSEMBL Gene Tree for MS4A15 (if available)
    TreeFam Gene Tree for MS4A15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MS4A15 gene
    MS4A182  MS4A4A2  MS4A82  MS4A122  
    2 SIMAP similar genes for MS4A15 using alignment to 5 protein entries:     M4A15_HUMAN (see all proteins):
    MS4A8    MS4A12

    MS4A15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 SNPs in MS4A15 are shown (see all 474)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3689096711,2
    C--60522438(+) TTTGT-/T/TT  
            
    TTTTT
    2 -- us2k10--------
    rs1450311901,2
    --60522496(+) CTCCTA/GAGCTC 2 -- us2k10--------
    rs352124541,2
    C,F--60522608(+) TTTGGG/ATATAT 2 -- us2k17Minor allele frequency- A:0.20NA WA EA 368
    rs1465800531,2
    --60522767(+) TGGAGC/TGCAGT 2 -- us2k10--------
    rs1886975341,2
    --60522840(+) CTCCCA/GAGACT 2 -- us2k10--------
    rs1389003301,2
    C--60523044(+) CTGCTC/TTGAGT 2 -- us2k10--------
    rs1419519201,2
    C--60523056(+) GTTGTA/CATGTC 2 -- us2k10--------
    rs1932884761,2
    --60523114(+) GGAGAC/TGGTGC 2 -- us2k10--------
    rs1843178951,2
    --60523115(+) GAGACA/GGTGCT 2 -- us2k10--------
    rs787947731,2
    C,F--60523381(+) TGTCCC/TTTGCC 2 -- us2k11Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for MS4A15 (60524340 - 60544205 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MS4A15: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MS4A15
    DNA2.0 Custom Variant and Variant Library Synthesis for MS4A15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MS4A15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MS4A15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219995 HGNC: 28573 AceView: MGC35295 Ensembl:ENSG00000166961 euGenes: HUgn219995
    ECgene: MS4A15 H-InvDB: MS4A15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MS4A15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MS4A15 gene:
    Search GeneIP for patents involving MS4A15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for MS4A15
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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