Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MS4A15 Gene

Aliases for MS4A15 Gene

  • Membrane Spanning 4-Domains A15 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 15 2

External Ids for MS4A15 Gene

Previous GeneCards Identifiers for MS4A15 Gene

  • GC00U915589
  • GC11P060280
  • GC11P060524
  • GC11P056871

Summaries for MS4A15 Gene

GeneCards Summary for MS4A15 Gene

MS4A15 (Membrane Spanning 4-Domains A15) is a Protein Coding gene. An important paralog of this gene is MS4A12.

UniProtKB/Swiss-Prot for MS4A15 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A15 Gene

Genomics for MS4A15 Gene

Regulatory Elements for MS4A15 Gene

Enhancers for MS4A15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G060759 0.5 Ensembl 5.7 +2.8 2756 0.4 RNF2 IKZF1 SPI1 MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A15
GH11G060774 1.1 Ensembl ENCODE 0.4 +18.6 18628 1.0 WRNIP1 ZNF2 RAD21 RFX5 ZNF366 ZNF143 ZNF263 ZNF654 USF2 REST CCDC86 ENSG00000255959 ENSG00000255845 PRPF19 ENSG00000257052 MS4A10 MS4A15
GH11G060763 0.9 ENCODE 0.4 +6.6 6566 0.8 HDGF TBP TBL1XR1 WRNIP1 NFXL1 RAD21 EGR1 ZNF143 ZNF207 RELB MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A8 MS4A15
GH11G060756 0.5 ENCODE 0.7 -0.1 -85 0.2 MITF CTCF CBFB SMC3 RAD21 MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A15
GH11G060761 0.6 ENCODE 0.4 +5.3 5271 1.2 HDGF CTCF SRF TBX21 ELK1 EED IKZF1 STAT3 ZNF207 IKZF2 MS4A18 MS4A8 MS4A15 MS4A10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MS4A15 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A15 Gene

60,756,867 bp from pter
60,776,733 bp from pter
19,867 bases
Plus strand

Genomic View for MS4A15 Gene

Genes around MS4A15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A15 Gene

Proteins for MS4A15 Gene

  • Protein details for MS4A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 15
    Protein Accession:
    Secondary Accessions:
    • A9UJY6
    • A9UJY7
    • F2Z2J5

    Protein attributes for MS4A15 Gene

    240 amino acids
    Molecular mass:
    25050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A15 Gene


neXtProt entry for MS4A15 Gene

Post-translational modifications for MS4A15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MS4A15 Gene

Domains & Families for MS4A15 Gene

Gene Families for MS4A15 Gene

Protein Domains for MS4A15 Gene


Suggested Antigen Peptide Sequences for MS4A15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A15: view

Function for MS4A15 Gene

Molecular function for MS4A15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A15 Gene

Localization for MS4A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A15 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A15: view

Pathways & Interactions for MS4A15 Gene

SuperPathways for MS4A15 Gene

No Data Available

Interacting Proteins for MS4A15 Gene

Gene Ontology (GO) - Biological Process for MS4A15 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A15 Gene

Drugs & Compounds for MS4A15 Gene

No Compound Related Data Available

Transcripts for MS4A15 Gene

mRNA/cDNA for MS4A15 Gene

Unigene Clusters for MS4A15 Gene

Membrane-spanning 4-domains, subfamily A, member 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - - -
SP3: -

Relevant External Links for MS4A15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A15 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A15 Gene

This gene is overexpressed in Lung (x49.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A15 Gene

Protein tissue co-expression partners for MS4A15 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A15 Gene:


SOURCE GeneReport for Unigene cluster for MS4A15 Gene:


Evidence on tissue expression from TISSUES for MS4A15 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with MS4A15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A15 Gene

Orthologs for MS4A15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A15 34 35
  • 98.89 (n)
(Bos Taurus)
Mammalia MS4A15 34 35
  • 87.09 (n)
(Mus musculus)
Mammalia Ms4a15 34 16 35
  • 83.56 (n)
(Rattus norvegicus)
Mammalia Ms4a15 34
  • 83.41 (n)
(Canis familiaris)
Mammalia MS4A15 34 35
  • 81.76 (n)
(Monodelphis domestica)
Mammalia MS4A15 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MS4A15 35
  • 70 (a)
(Gallus gallus)
Aves MS4A15 35
  • 34 (a)
(Anolis carolinensis)
Reptilia MS4A15 35
  • 28 (a)
(Danio rerio)
Actinopterygii ms4a17a.14 35
  • 28 (a)
FP015791.1 35
  • 27 (a)
ms4a17a.11 35
  • 27 (a)
ms4a17a.6 35
  • 26 (a)
ms4a17a.7 35
  • 26 (a)
ms4a17a.8 35
  • 26 (a)
ms4a17a.10 35
  • 25 (a)
ms4a17a.3 35
  • 25 (a)
ms4a17a.5 35
  • 25 (a)
ms4a17a.9 35
  • 25 (a)
si:ch73-56d11.4 35
  • 25 (a)
ms4a17a.1 35
  • 24 (a)
ms4a17a.2 35
  • 24 (a)
ms4a17a.4 35
  • 24 (a)
si:dkey-77f5.10 35
  • 24 (a)
ms4a17c.1 35
  • 23 (a)
si:ch73-56d11.3 35
  • 23 (a)
si:dkey-238j22.1 35
  • 22 (a)
si:dkey-174k12.3 35
  • 21 (a)
ms4a17a.17 35
  • 20 (a)
ms4a17c.2 35
  • 20 (a)
Species where no ortholog for MS4A15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A15 Gene

Gene Tree for MS4A15 (if available)
Gene Tree for MS4A15 (if available)

Paralogs for MS4A15 Gene

Paralogs for MS4A15 Gene

(2) SIMAP similar genes for MS4A15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MS4A15: view

Variants for MS4A15 Gene

Sequence variations from dbSNP and Humsavar for MS4A15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000181424 -- 60,756,325(+) CGCTC(C/T)CGTGC upstream-variant-2KB
rs1000207249 -- 60,761,544(+) CATGG(G/T)TATCT intron-variant
rs1000232750 -- 60,756,241(+) GGTGT(A/G)TGTTT upstream-variant-2KB
rs1000298965 -- 60,773,612(+) ACCCC(A/T)TGAAT intron-variant
rs1000301091 -- 60,760,522(+) CATGC(C/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A15 Gene

Variant ID Type Subtype PubMed ID
esv3579733 CNV loss 25503493
nsv478650 CNV novel sequence insertion 20440878
nsv975191 CNV duplication 23825009

Variation tolerance for MS4A15 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.29; 92.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A15 Gene

Disorders for MS4A15 Gene

Relevant External Links for MS4A15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A15 Gene

Publications for MS4A15 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for MS4A15 Gene

Sources for MS4A15 Gene

Loading form....