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MS4A15 Gene

protein-coding   GIFtS: 39
GCID: GC11P060524

Membrane-Spanning 4-Domains, Subfamily A, Member 15

  Search for MS4A15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 151 2
Membrane-Spanning 4-Domains Subfamily A Member 152

External Ids:    HGNC: 285731   Entrez Gene: 2199952   Ensembl: ENSG000001669617   UniProtKB: Q8N5U13   

Export aliases for MS4A15 gene to outside databases

Previous GC identifers: GC00U915589 GC11P060280 GC11P056871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MS4A15 Gene:
MS4A15 (membrane-spanning 4-domains, subfamily A, member 15) is a protein-coding gene. An important paralog of this gene is MS4A18.

UniProtKB/Swiss-Prot: M4A15_HUMAN, Q8N5U1
Function: May be involved in signal transduction as a component of a multimeric receptor complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MS4A15 gene promoter:
         COUP-TF1   AhR   Max1   NF-1   NF-1/L   STAT1   COUP   Arnt   COUP-TF   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A15 promoter sequence
   Search Chromatin IP Primers for MS4A15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MS4A15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

MS4A15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A15 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060524:  view genomic region     (about GC identifiers)

Start:
60,524,340 bp from pter      End:
60,544,205 bp from pter
Size:
19,866 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: M4A15_HUMAN, Q8N5U1 (See protein sequence)
Recommended Name: Membrane-spanning 4-domains subfamily A member 15  
Size: 240 amino acids; 25050 Da
Secondary accessions: A9UJY6 A9UJY7 F2Z2J5
Alternative splicing: 3 isoforms:  Q8N5U1-1   Q8N5U1-2   Q8N5U1-3   

Explore the universe of human proteins at neXtProt for MS4A15: NX_Q8N5U1

Explore proteomics data for MS4A15 at MOPED


See MS4A15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001092305.1  NP_001265171.1  NP_689930.1  

ENSEMBL proteins: 
 ENSP00000434165   ENSP00000338692   ENSP00000413918   ENSP00000386022  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007237 CD20-like

Graphical View of Domain Structure for InterPro Entry Q8N5U1

ProtoNet protein and cluster: Q8N5U1

UniProtKB/Swiss-Prot: M4A15_HUMAN, Q8N5U1
Similarity: Belongs to the MS4A family


MS4A15 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: M4A15_HUMAN, Q8N5U1
Function: May be involved in signal transduction as a component of a multimeric receptor complex (By similarity)

Phenotypes:
     1 GenomeRNAi human phenotype for MS4A15:

 Decreased Wnt reporter activit 

Animal Models:
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2 qRT-PCR Assays for microRNAs that regulate MS4A15:
hsa-miR-539 hsa-miR-3175
SwitchGear 3'UTR luciferase reporter plasmidMS4A15 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector (see all 2): MS4A15 (NM_001098835)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A15

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
M4A15_HUMAN, Q8N5U1: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

MS4A15 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MS4A15
Interactions:

    Search GeneGlobe Interaction Network for MS4A15

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MS4A15 (M4A15)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MS4A15 gene (3 alternative transcripts): 
NM_001098835.1  NM_001278242.1  NM_152717.2  

Unigene Cluster for MS4A15:

Membrane-spanning 4-domains, subfamily A, member 15
Hs.207465  [show with all ESTs]
Unigene Representative Sequence: AK091846
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000528170 ENST00000337911(uc001npx.2) ENST00000429322(uc001npy.2 uc009yng.1)
ENST00000405633(uc009ynf.1)
miRNA
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2 qRT-PCR Assays for microRNAs that regulate MS4A15:
hsa-miR-539 hsa-miR-3175
SwitchGear 3'UTR luciferase reporter plasmidMS4A15 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MS4A15
Predesigned siRNA for gene silencing in human, mouse, rat MS4A15
Clone
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Primer
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OriGene qPCR primer pairs and template standards for MS4A15
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MS4A15
  QuantiTect SYBR Green Assays in human, mouse, rat MS4A15
  QuantiFast Probe-based Assays in human, mouse, rat MS4A15

Additional mRNA sequence: 

AK091846.1 AK300233.1 AY584608.1 AY584609.1 BC031610.1 

3 DOTS entries:

DT.75167330  DT.100020760  DT.95258656 

11 AceView cDNA sequences:

NM_152717 BC031610 AK091846 AX747218 CB044496 AI797091 BM996493 CB044497 
BX117401 BI818815 BI824549 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MS4A15    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1:              -                                                   
SP2:        -     -                 -                                 
SP3:                                -                                 


ECgene alternative splicing isoforms for MS4A15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MS4A15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MS4A15 Expression
About this image

MS4A15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MS4A15 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.207465
    Custom PCR Arrays for MS4A15
Primer
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QuantiFast Probe-based Assays in human, mouse, rat MS4A15
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A15

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MS4A15 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ms4a151 , 5 membrane-spanning 4-domains, subfamily A, member 151, 5 83.56(n)1
87.21(a)1
  19 (7.47 cM)5
5452791  NM_001034898.21  NP_001030070.11 
 109783075 
chicken
(Gallus gallus)
Aves MS4A156
membrane-spanning 4-domains, subfamily A, member 1...
34(a)
1 ↔ 1
5(476599-482298) ENSGALG00000020513
lizard
(Anolis carolinensis)
Reptilia MS4A156
membrane-spanning 4-domains, subfamily A, member 1...
28(a)
1 ↔ 1
GL343235.1(85064-109424)
zebrafish
(Danio rerio)
Actinopterygii ms4a17a.146
ms4a17a.116
(see all 21)
membrane-spanning 4-domains, subfamily A, member 1...
membrane-spanning 4-domains, subfamily A, member 1...
(see all 21)
28(a)
27(a)
(see all 21)
many ↔ many
many ↔ many
(see all 21)
4(60581972-60613219) ENSDARG00000094809
4(60617632-60630485) ENSDARG00000053561


ENSEMBL Gene Tree for MS4A15 (if available)
TreeFam Gene Tree for MS4A15 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MS4A15 gene
MS4A182  MS4A4A2  MS4A82  MS4A122  
2 SIMAP similar genes for MS4A15 using alignment to 2 protein entries:     M4A15_HUMAN (see all proteins):
MS4A8    MS4A12

MS4A15 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MS4A15 (see all 474)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3689096711,2
C--60522438(+) TTTGT-/T/TT  
        
TTTTT
2 -- us2k10--------
rs1450311901,2
--60522496(+) CTCCTA/GAGCTC 2 -- us2k10--------
rs352124541,2
C,F--60522608(+) TTTGGG/ATATAT 2 -- us2k17Minor allele frequency- A:0.20NA WA EA 368
rs1465800531,2
--60522767(+) TGGAGC/TGCAGT 2 -- us2k10--------
rs1886975341,2
--60522840(+) CTCCCA/GAGACT 2 -- us2k10--------
rs1389003301,2
C--60523044(+) CTGCTC/TTGAGT 2 -- us2k10--------
rs1419519201,2
C--60523056(+) GTTGTA/CATGTC 2 -- us2k10--------
rs1932884761,2
--60523114(+) GGAGAC/TGGTGC 2 -- us2k10--------
rs1843178951,2
--60523115(+) GAGACA/GGTGCT 2 -- us2k10--------
rs787947731,2
C,F--60523381(+) TGTCCC/TTTGCC 2 -- us2k11Minor allele frequency- T:0.06WA 118

HapMap Linkage Disequilibrium report for MS4A15 (60524340 - 60544205 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MS4A15: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MS4A15
DNA2.0 Custom Variant and Variant Library Synthesis for MS4A15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MS4A15 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MS4A15)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
  7. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 219995 HGNC: 28573 AceView: MGC35295 Ensembl:ENSG00000166961 euGenes: HUgn219995
ECgene: MS4A15 H-InvDB: MS4A15

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MS4A15 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MS4A15 gene:
Search GeneIP for patents involving MS4A15

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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